

![0_image_0.png](0_image_0.png)

rithm. For instance, using CLASP, we compute the following answer to the query above: "ADRB1".

- We construct an algorithm to provide minimal explanations to the answers. For instance, for "ADRB1" our algorithm provides the following minimal explanation:
the drug "Epinephrine" targets the gene "ADRB1" according to CTD and the gene "ADRB1" interacts with the gene "DLG4" according to BIOGRID.

The applicability of our methods is illustrated with some complex queries over PHARMGKB, DRUGBANK, BIOGRID, SIDER and CTD, using the ASP systems CLASP
(with GRINGO), DLV and DLVHEX.

Acknowledgments. This work has been supported by TUBITAK Grant 108E229.

## References

1. Bodenreider, O., Coban, Z.H., Doganay, M.C., Erdem, E.: A preliminary report on answering complex queries related to drug discovery using answer set programming. In: Proc. of the 3rd