The subject site was the location of the first General Hospital in Sydney which operated between 1788 and 1816. In 1797 High (George) Street was realigned. The realignment required the portable hospital to be pulled down and re-erected on a stone foundation slightly west of its original location. A store and dispensary were then erected to the north and west of the hospital buildings. In 1816 the Sydney Hospital opened in Macquarie Street and the old hospital closed.
