With respect to his main focus of clinical research into jawbone infections like osteomyelitis and osteonecrosis, his work led to the development of novel in vitro and in vivo models to study biofilms, and unique antimicrobial strategies against biofilm pathogens. Sedghizadeh helped test novel cold plasma-based antibiofilm therapeutics for dental applications as a transdisciplinary collaboration with plasma physicists and plasma engineers at USC. In a collaboration with electrical engineers and electromicrobiologists, he characterized and discovered electrically conductive nanowires in pathogenic biofilms isolated from his patients with jawbone infections. Working with chemists, Sedghizadeh designed and tested novel bone-targeted antibiotic conjugates to treat bone infections.
