Louisville Central's 2007, 2008, 2010, 2011, 2012 and 2018 football team become 3A champions and their basketball team won 2008's regional basketball championship. It one of two schools in the county attending the sweet sixteen games. Their band, featuring the "Yellow Jacket Drumline", "The Twirlettes" and the "Stingettes" majorette dance team, has become one of the most talented musical ensembles in the region; it is also the first in the county to incorporate majorettes.
