In vertebrates, the cerebellum is suggested to facilitate split-belt adaptation, and in mice, the interposed cerebellar nucleus is particularly crucial for this form of adaptation. Additionally, somatomotor regions of cerebral cortex in mice are shown to be not involved in split-belt adaptation. The split-belt adaptation paradigm is clinically important for aiding in the adjustment or recovery of impaired limb coordination patterns resulting from injury or pathologies, as well as understanding the specific aspects (e.g. temporal or spatial components) of gait that are disrupted in gait pathologies.
