Leigh subsequently appeared opposite her daughter, Jamie Lee Curtis, in John Carpenter's supernatural horror film The Fog (1980), in which a phantom schooner unleashes ghosts on a small coastal community. Leigh would appear opposite her daughter once again in Halloween H20: 20 Years Later (1998), playing the secretary of Laurie Strode. On television, Leigh acted in the Murder, She Wrote episode "Doom with a View" (1987), as Barbara LeMay in an episode of The Twilight Zone ("Rendezvous in a dark place", 1989) and the Touched by an Angel episode "Charade" (1997). She guest-starred twice as different characters on both Fantasy Island and The Love Boat, as well as Tales of the Unexpected. Leigh continued to grant interviews and appear at red carpet events through the early 2000s. Her final film credit was in the teen film Bad Girls from Valley High (2005), opposite Christopher Lloyd.
