Functional anatomical studies of visual cortex that employed 2-14C-deoxyglucose autoradiography were another important tool in De Valois' investigations of spatial and chromatic vision. In a series of papersTootell, R.B.H., Silverman, M.S. & De Valois, R.L., "Spatial frequency columns in primary visual cortex", Science, 214: 813-815 (1981).Tootell, R.B.H., Silverman, M.S., Switkes, E. & De Valois, R.L., "Deoxyglucose analysis of retinotopic organization in primate striate cortex", Science 218: 902-904 (1982)Tootell, R.B.H., Silverman, M.S., De Valois, R.L. & Jacobs, G.H., "Functional organization of the second cortical visual area in primates", Science 220: 737-739 (1983).Tootell, R.B.H., Silverman, M.S., Hamilton, S.L., De Valois, R.L. & Switkes, E., "Functional anatomy of macaque striate cortex. III. Color", J. Neurosci. 8: 1569-1593 (1988)- Tootell, R.B.H., Silverman, M.S., Hamilton, S.L., Switkes, E. & De Valois, R.L., "Functional anatomy of macaque striate cortex. V. Spatial frequency", J. Neurosci. 8: 1610-1624 (1988) R. Tootell, M. Silverman, E. Switkes, R. De Valois, and others, showed: i. the columnar arrangement of neurons that respond to similar spatial frequencies in striate cortex; ii. the structured relationship of cytochrome-oxidase (CYTOX) rich regions ("blobs and stripes") in primary and secondary visual cortex; and iii. the topographic relationship between CYTOX blobs and neurons tuned to spatial frequency or color. The deoxyglucose studies also provided illustrations of previously known retinotopic organization and ocular dominance columns Switkes, E., Tootell, R.B.H., Silverman, M.S. & De Valois, R.L., "Picture processing techniques applied to autoradiographic studies of visual cortex", J. Neurosci. Meth. 15: 269-280 (1986).
