Tsaganeas was born in Brăila, Romania. He starred in several movies, his most famous role being the college headmaster in To xylo vgike ap' ton paradeiso. His first important role was in The Germans are Coming with Vassilis Logothetidis where he says the well known phrase Anthropoi, anthropoi. Aimostageis, aimodipseis kai aimovoroi. Pros ti to missos ke o allilosparagmos. He married, secondly, to Nitsa Tsaganea. He died on his 70th birthday and was buried in the First Cemetery. His wife and their daughter were later buried alongside him.
