In the 2001 Copa America, head coach Sergio Markarián selected a squad of mostly domestic based players. Paraguay were drawn against Peru, Mexico and Brazil. In their opening fixture on 12 July, the fixture ended 3–3. On 15 July, Paraguay drew 0–0 with Mexico in their second group stage fixture. Paraguay then faced Brazil on 18 July in their last group stage fixture. Brazil won 3–1 and eliminated Paraguay, who had obtained just two points at the competition.
