The second half of the game turned into an offense shootout, with both teams capitalizing on big plays, while the defense struggled consistently getting off of the field. Mitch Ewald kicked a field goal for the Hoosiers after their first drive of the half, which was followed by a 67-yard touchdown run for Miller and the Buckeyes. Indiana scored their first passing touchdown of the game in the third quarter on a pass from Cameron Coffman to Shane Wynn. Carlos Hyde scored a touchdown for Ohio State on a 14-yard run, giving the Buckeyes a 38–27 lead heading into the fourth quarter. The offensive shootout continued into the fourth quarter with Indiana dominating the Ohio State defense for most of the quarter. Hyde scored another rushing touchdown early in the fourth quarter, giving the Buckeyes a 45–27 lead. A Hoosier rushing touchdown, followed by a Miller touchdown pass, kept Ohio State ahead 52–34 midway through the fourth quarter. The Hoosiers mounted a comeback later in the fourth with Indiana scoring on a 12-yard touchdown pass and closing the lead to a 14-point game. An onside kick recovered by the Hoosiers allowed them to drive down and score on another pass touchdown from quarterback Nate Sudfeld, with the two-point conversion successful. Ohio State recovered the final onside kick and avoided the upset, insuring their 52–49 win and a 7–0 record on the season, as well as a 3–0 conference record. Carlos Hyde led the Buckeyes in rushing with 156 yards and one touchdown. Braxton Miller led the Buckeyes in passing yards with 211 and three touchdowns.
