Kruger was brought to Hollywood by Samuel Goldwyn. She appeared in her first film These Three (1936) while in her 60s. She then proceeded to act in over 40 films in the space of little more than a decade. Among her notable roles was Nurse Molly Byrd, the superintendent of nurses in the popular Dr. Kildare/Dr. Gillespie film series, appearing in all but the first two of the 16 movies.
