The 2010–2011 season may have begun with some renewed hope for a resurgence of Biedriņš, as 2009–10 coach Don Nelson was fired and the potential existed for new head coach Keith Smart to unleash and reinvigorate the center's fragile confidence. Early returns were promising, as Biedriņš had several games in the early season with rebounding numbers at or around double-digits while averaging around thirty minutes per game, including 20 rebounds in a November 5 victory over the Utah Jazz, 28 points and 20 rebounds in a November 26 loss to the Memphis Grizzlies, and 18 rebounds in a November 30 loss to the San Antonio Spurs. However, the injury bug bit again, derailing Biedriņš from mid-December 2010 to early January 2011, and once again he found it difficult to regain his previous form. Biedriņš's slumping play and persistent foul issues convinced Smart to bench him in favor of rookie Ekpe Udoh for four games in March. He was reinstated into the starting lineup for five games until spraining his ankle on March 16, resulting in his being sidelined for the remainder of the season. Biedriņš's averages for the 2010–11 season amounted to five points, 7.2 rebounds and 0.9 blocks (both a drop from 2009–10) on 53.4% field goal shooting and a modestly improved 32.3% free throw accuracy.
