On 7 June 1805, Nancy, Cook, master, sailed from Antigua in a convoy of 15 merchantmen under the escort of and . They had the misfortune on 8 June to encounter a Franco-Spanish fleet under Admiral Villeneuve. The two British warships managed to escape, but Villeneuve's fleet captured the entire convoy, valued at some five million pounds. He sent the convoy to Guadeloupe under the escort of the frigate .James (1837), Vol. 3, p.351. However, on her way Sirène encountered several British frigates. She escaped after burning the merchantmen on 17 June.Lloyd's List №4252.
