"Not Myself Tonight" was released as Bionics lead single on April 2, 2010. It debuted and peaked at number twenty-three on the US Billboard Hot 100, becoming Aguilera's third highest solo debut on the chart after "Keeps Gettin' Better" (2008) and "Ain't No Other Man" (2006). Internationally, the song was a moderate commercial success, peaking at number twelve in the United Kingdom, and within the top forty in Australia, Austria, New Zealand and Sweden. The song received generally positive reviews from music critics, who complimented its club nature and Aguilera's vocals on the track; some reviewers also referred to it as her best uptempo recording since her single "Dirrty" (2002). The accompanying music video, directed by Hype Williams, featured a S&M theme with Aguilera sporting different bondage-inspired looks. Paying homage to Madonna's music videos for "Express Yourself" (1989) and "Human Nature" (1995), the video received mixed reviews from critics, who complimented its aesthetic but called it unoriginal.
