The most important extension was a connection between Afula and Jerusalem. Its construction started in 1912, and the first 17 km section was completed at the beginning of 1913, connecting Afula with Jenin. Meissner's full plan never bore fruit however, because of the French government's extreme pressure on the Ottoman government to cancel the project, which would compete with the French-owned Jaffa–Jerusalem railway. By 1914, only 40 km were built from Afula, and the line terminated near the village Silat ad-Dhahr (Sileh). During World War I, the southward connection became essential for supplying the troops in the Sinai Peninsula, so from January 1915, the construction continued, reaching Nablus in the spring of 1915. At this point, the original plan for a southward line to Jerusalem was no longer relevant, and instead, from a junction at Mas'udiya near Sebastia the construction continued westward to Tulkarm and from there southward, reaching Lydda in the summer of 1915, and Beersheba in October 1915. In the same year, the existing railway between Lydda and Jerusalem was converted from metre gauge to 1,050 mm gauge, to enable interoperation with the new Afula–Beersheba railway. Its section between Tulkarm and Lydda became known as the Eastern Railway and remained in active use until 1969, even though the rest of the Afula–Nablus–Tulkarm branch line ceased operation in the 1930s.
