James Cunningham from Hardcore Gamer lauded Neon Abyss as "highly playable", praising the large variety of perks and weapons available to players as well as the satisfactory implementation of the game's powerup progression within each run. Simon Fitzgerald from Push Square summarized Neon Abyss as a "fun, fast-paced twist on the rogue-like genre with a solid core gameplay loop", highlighting the variety of weapons, enemies and synergies as well as the novel collectible egg mechanic for praise. Drew Hurley from Cubed3 drew favorable comparisons to other roguelike games like The Binding of Isaac and Enter the Gungeon with its fast and fluid gameplay, striking presentation, and generous amount of unlockable content. Stuart Gipp from Nintendo Life opined that Neon Abyss has much to offer as it possesses all of the essential elements that make it a fun and compelling roguelike: "a good challenge, lovely controls and plenty of scope for craziness".
