On October 24, 1837, William married his cousin, Esther Phillips Wetmore of Middletown, Connecticut, at Gloucester Lodge, Regent's Park, London. She was the daughter of his uncle Samuel Wetmore and a sister of Mary Cryder. The following year, a daughter was born in New York City, who died at birth or soon thereafter on October 12, 1838. Esther died on October 26, 1838.
