The area now known as the Village of Whitehouse was originally occupied by various Native American tribes, such as the Miami, Ottawa, Shawnee, Wyandot, and Delaware. Settlers of European descent began travelling through the Northwestern Territory after "Mad" Anthony Wayne's victory at the Battle of Fallen Timbers in 1794. Many settlers were of German or Dutch descent in search of farmland. Canal access also attracted many settlers to this particular area. A post office was established as Whitehouse in 1856. Whitehouse was platted in 1864. The village was named for Edward Whitehouse, a railroad official and treasurer of the Wabash Railroad.
