To finish the season, the Lions hosted their divisional rivals the Minnesota Vikings for a rematch of week 9. The Lions opened the scoring in the first quarter via a 43-yard touchdown pass from Matthew Stafford to Marvin Jones. The Vikings responded with a 28-yard touchdown pass from Kirk Cousins to Alexander Mattison. The teams exchanged touchdowns in the second quarter, via a 20-yard touchdown pass from Stafford to Quintez Cephus for the Lions, and a four-yard touchdown pass from Cousins to Ameer Abdullah for the Vikings. The Lions regained the lead via a 54-yard field goal by Matt Prater. The Vikings responded with a 40-yard touchdown pass from Cousins to Chad Beebe, making the score 21–16 in favor of Minnesota at half-time. The Lions regained the lead in the third quarter via a 26-yard touchdown pass from Stafford to Jones. The Vikings responded with 10 points via a two-yard touchdown run from Mattison and a 23-yard field goal by Dan Bailey. The Lions responded with a two-yard touchdown run from Adrian Peterson. The Vikings extended their lead in the fourth quarter via a one-yard touchdown run from Cousins. The Lions scored the final points of the game via a two-yard touchdown run from D'Andre Swift, making the final score 37–35 in favor of Minnesota. The Lions finished 5–11, and last place in the NFC North for the third consecutive season.
