In farmland, shrews are likely to be affected by pesticides either through secondary contamination by the food chain or by direct exposure. Destruction of habitat boundaries, including markers such as forest limits and grass lines, diminish S. macrodon survival rates within small and sparse distribution. As a result, even small natural disasters or human interferences – such as mining operations, livestock ranching, wood-harvesting, or forest fires – could exterminate the entire population. Unfortunately, the Mexican large-toothed shrew is very poorly known, even in its native country. In summary, agriculture and urbanization pose major extinction threats to Sorex macrodon.
