In the state of Iowa, U.S. Route 34 is a major east–west arterial surface road across southern Iowa. It enters Iowa west of Glenwood and then passes through Glenwood, Red Oak, Corning, and Creston before intersecting Interstate 35 at Osceola. East of Osceola, it continues through Chariton and Georgetown then onto Albia before meeting U.S. Route 63 at a traffic circle in Ottumwa.
