In 1496, the ambassador of the Republic of Florence, Giovanni de' Medici il Popolano, paid a visit to Caterina. The second son of Pierfrancesco il Vecchio, he belonged to a collateral branch of the Medici family. Along with his older brother Lorenzo, he had been sent into exile because of his open hostility toward their cousin Piero, who succeeded his father Lorenzo il Magnifico in the government of Florence. In 1494, when Charles VIII invaded Italy, Piero was forced to sign a treaty which allowed the French army to move freely into the Kingdom of Naples. The people of Florence were liberated, deposed Piero and proclaimed a Republic. Giovanni and his brother were able to return to their homeland. They renounced the Medici surname and took the name of "Popolano". The Florentine government appointed Giovanni as ambassador to Forlì.
