The Browns were able to take a 35–34 lead in the fourth quarter on a Baker Mayfield touchdown pass to Rashard Higgins and a Mayfield touchdown run. Meanwhile, Jackson left the game for Baltimore due to an injury and backup Trace McSorley came in and struggled against the Browns' defense. After the two-minute warning, Jackson returned to the game and threw a 44-yard touchdown pass to Marquise Brown to take a 42–35 lead after a successful 2-point conversion. Mayfield led the Browns to a touchdown drive culminating in a touchdown pass to Kareem Hunt with just over a minute left. However, Baltimore kicker Justin Tucker kicked a game-winning 55-yard field goal with 0:02 remaining to go up 45–42. Baltimore added a safety on a failed hook-and-ladder play by Cleveland to make the final score 47–42.
