Don Bosco is traversed by Doña Soledad Avenue which also provides access to surrounding communities of Sun Valley, Marcelo Green and Moonwalk at its west end. An extension in Moonwalk known as E. Rodriguez Street leads motorists to the C-5 Road Extension and eventually to Ninoy Aquino Avenue in Santo Niño via Multinational Avenue. South Luzon Expressway and the elevated Skyway serve as the village's eastern boundary. The main north–south thoroughfare of Don Bosco is France Street in Better Living Subdivision which leads to San Antonio in the south through a maze of narrow residential streets.
