Maniac follows Annie Landsberg and Owen Milgrim (see also Milgram experiments), two strangers who connect during a risky, psychologically intense, twelve-person, mind-bending pharmaceutical trial conducted by Neberdine Pharmaceutical Biotech (NPB). The experiment, originally overseen by Dr. Robert Muramoto and Dr. Azumi Fujita, later falls under the purview of the study's original designer, the eccentric Dr. James K. Mantleray. Together, Annie and Owen go on a mind-bending odyssey through various hallucinatory worlds.
