The Montgomery Building was home to more than just mill engineers and mill management. In 1926, shortly after it opened, its tenants included several physicians, several attorneys, several real estate agents, and a number of life insurance companies. Other businesses included a cotton broker, the local offices of the Clinchfield Railroad, and the local offices of a coal mining and sales company. Spartanburg's Chamber of Commerce, the Community Chest, and the county tuberculosis association also had offices in the building. On the ground floor, a ladies’ clothing and hat store, a post office, and the theater were among the tenants. After 1930, South Carolina's first AM radio station, WSPA, operated out of the Montgomery Building.
