In Week 2 of the 2021 season, the Bills won 35–0 in Miami behind a strong rushing attack and defensive performance as Allen surpassed 10,000 career passing yards in the game. The Dolphins surrendered 6 sacks to the Bills defense, also losing quarterback Tua Tagovailoa to a rib injury in the first quarter. The 35–0 win was the largest margin of victory by Buffalo in the series. With a 26–11 Bills home win on October 31, 2021, Buffalo achieved a team-record seventh straight victory in the series.
