The Blasters played the most number of pre-season friendlies among all ISL clubs prior to the start of league season. In this season, the Blasters made their debut in the Durand Cup by participating in the tournament's 2021 edition, but was knocked out in the group stages of the tournament. The club had a serious change in the rosters, as they appointed Ivan Vukomanović as their new manager for the season, and released all the foreign players from the last season and recruited the likes of Adrián Luna, Jorge Pereyra Díaz, Álvaro Vázquez, Enes Sipović and Chencho Gyeltshen. They also signed several young Indian players and the experienced players like Harmanjot Khabra and Karanjit Singh from the summer and winter transfer windows respectively.
