Coming off their loss to the Cardinals, the Rams stayed at home for a Monday Night fight with the current NFC North champion Chicago Bears. After a scoreless first quarter, the Rams struck first with QB Marc Bulger completing a 1-yard TD pass to WR Torry Holt, yet the PAT attempt had a botched snap, making it no good. However, immediately following St. Louis's first score, the Bears took the lead with DB Devin Hester returning a kickoff 94 yards for a touchdown. Fortunately, the Rams responded with RB Steven Jackson's 2-yard TD run, yet Chicago responded with QB Rex Grossman's 34-yard TD pass to WR Bernard Berrian. St. Louis tried to get a 48-yard field goal in before halftime, yet it just went wide right. In the third quarter, the Rams' recent struggles continued with RB Thomas Jones's 30-yard TD run, while Grossman completed a 14-yard TD pass to WR Muhsin Muhammad. In the fourth quarter, the Bears dominance continued with RB Adrian Peterson's 1-yard TD run. St. Louis tried to come back with Bulger completing a 6-yard TD pass to Holt, yet Hester immediately followed that up with a 96-yard kickoff return for a touchdown, which gave him the single-season record for the most returns for a touchdown with six. The only thing remaining within St. Louis was Jackson's 2-yard TD run. With their second-straight loss, the Rams fell to 5–8.
