In the 19th century, the basin was inhabited by the Northern Paiute tribe. It was explored and extensively trapped by trappers of the Hudson's Bay Company in the 1820s. The basin lay far off the route of the Oregon Trail, but in 1845 experienced mountain man Stephen Meek led an ill-fated party across the basin via Stinkingwater Pass, seeking a shortcut to The Dalles along what has become known as the Meek Cutoff. A total of 23 people died while the party wandered in the basin until finding water at the Crooked River.
