Clark succeeded Jenni Lomax OBE, who was the Director of Camden Arts Centre for 27 years, between 1990 and 2017. Under her stewardship, Camden Arts Centre established a programme of exhibitions, including solo shows by Anya Gallaccio, Tal R, Victor Grippo, Yinka Shonibare, Hanne Darboven, Kara Walker, Eva Hesse, Laura Owens, Kerry James Marshall, and  Angela de la Cruz, whose first solo exhibition in the UK, entitled 'After', was held at Camden Arts Centre in April and May 2010. She was nominated for the Turner Prize in 2010.
