After leaving the Sioux Falls area, I-29 continues north toward Brookings. The highway serves the EROS Data Center and United States Geological Survey near Baltic. The highway then continues north and intersects the northern terminus of SD 115 west of Dell Rapids. This is I-29's last exit before leaving Minnehaha County and entering Moody County. The highway continues due north to an interchange with SD 34 near Madison. Just north of here, the route shares an interchange with SD 32, a highway that serves nearby Flandreau, South Dakota. The highway has a rest stop north of the Flandreau exit before entering Brookings County. The highway's first exit in Brookings County, serves SD 324. After this interchange, I-29 enters Brookings and has two exits in the city. The first is an interchange with US 14 at exit 132. This exit is also a signed business spur of I-29. Exit 133 serves the bypass route of US 14, signed as "US 14B". After these exits, the highway continues north toward Watertown.
