Burrell hit a game-winning two-run home run in the 12th inning of a 3–1 victory over Boston on April 17, 2010. On April 27, he hit a game-winning three-run home run in an 8–6 victory over the Oakland Athletics. In his first 24 games of the season, Burrell batted .202 with two home runs and 13 RBI. On May 15, he was designated for assignment and replaced on the Rays' roster by Hank Blalock. Four days later, he became a free agent after clearing waivers.
