I-10 heads east from the Downtown Los Angeles Eastside Los Angeles region to I-710 in Monterey Park. It then continues Alhambra, Rosemead, San Gabriel, El Monte, and Baldwin Park before intersecting with I-605. It then travels through West Covina and Covina before heading up Kellogg Hill into San Dimas, where I-10 intersects with SR 57 (formerly part of I-210) and SR 71 at the Kellogg Interchange. I-10 then heads east through Pomona and Claremont, leaving Los Angeles County to enter San Bernardino County.
