The house was built by Nathanael Greene in 1770, part of a property encompassing , and served as his family's home through the Revolutionary War. In 1783 Greene moved the family to Newport, before eventually relocating to Georgia, where he died in 1786. This house he sold to his brother Jacob. It remained in Greene family hands until 1899, although it became run-down and was used as a tenement house in the later years. In 1919 the Nathanael Greene Homestead Association was formed to restore and care for the property. It is now a house museum, open to the public.
