Tyamzashe married Mercy Gladys Xiniwe in 1918 and had four sons and two daughters with her. He remarried after his wife’s death in 1938 however, this marriage was unsuccessful. In 1950, shortly before his retirement, he married Agnes Nomasango. She died a few years after their marriage. Tyamzashe died due to cardiac failure at Frere Hospital in East London. He was buried on his farm in Zinyoka near King Williams Town. He is survived by his six children, all from his first marriage to Mercy.
