On 14 April 2022, Wong was selected as the leader of the PAP's fourth-generation (4G) team, succeeding Deputy Prime Minister Heng Swee Keat, who had stepped down as 4G leader on 8 April 2021. Prior to his appointment, Prime Minister Lee Hsien Loong delegated former PAP chairman Khaw Boon Wan to initiate a consultation process among the fourth-generation ministers of the Cabinet, aimed at garnering their individual views regarding the selection of a new 4G leader. However, both Prime Minister Lee and Senior Ministers Tharman Shanmugaratnam and Teo Chee Hean, abstained from participating in the process.
