On October 4, 2009, Talib recorded four solo tackles, three pass deflections, and had a career-high three interceptions off of Washington Redskins' quarterback Jason Campbell during their 16–13 loss. Talib was inactive for the Buccaneers' Week 13 loss at the Carolina Panthers. On December 20, 2009, he collected a season-high eight combined tackles in their 24–7 win at the Seattle Seahawks. He finished the season with a career-high 64 combined tackles (56 solo), 15 passes defensed, and five interceptions in 15 games and 15 starts. Defensive coordinator Jim Bates was fired after a 1–9 start and the Tampa Bay Buccaneers finished the season with a 3–13 record.
