In 1940, Nizami left the Orient Press and founded the Nawa-i-Waqt newspaper. He became the newspaper's first editor-in-chief from Lahore on 23 March 1940. The Nawa-i-Waqt was a monthly newspaper but he quickly converted the newspaper into weekly on 15 December 1942. After hiring more staff and gaining more credibility, the Nawa-i-Waqt began publishing as a daily newspaper on 19 July 1944. The first edition of the Nawa-i-Waqt came out on 22 July 1944 with a Muslim prayer and a message of Muhammad Ali Jinnah in it.
