The rail line serves the cities that Radial Road 6 (Marcos Highway, Aurora Boulevard, Ramon Magsaysay Boulevard, Legarda Street and Recto Avenue) passes through: Manila, San Juan, Quezon City, Marikina, Pasig (depot), and Antipolo. The rails are mostly elevated and erected either over or along the roads covered, with sections below ground before and after the station, the only underground station on the line.
