SR 241 travels around the eastern outskirts of Sunnyside, passing several food processing plants and the Sunnyside Municipal Airport, before leaving the city. It continues north into rolling farmland on Hanford Road, turning northeast to follow Sulphur Creek as it ascends into the Rattlesnake Hills. Within the Rattlesnake Hills, the highway leaves the creek and crosses barren rangelands and shrub-steppe highlands. SR 241 turns north and northeasterly to follow a pass in the hills and begins its descent into the pastures of the Black Rock Valley. The highway briefly crosses into Benton County and re-enters Yakima County while turning northwest to avoid a part of the Yakima Ridge. SR 241 terminates at a junction with SR 24, the main east–west route between Yakima and the Hanford area, at the Silver Dollar Cafe.
