Decades later in 1952, as a booming post-war population in Oxnard made it necessary to build a larger hospital, a two-story building with 75 patient beds was opened and dedicated by Cardinal James Francis McIntyre. This hospital was located on F Street in Oxnard. During the next 35 years, as community need grew, St. John's continued to expand the facility with the addition of two floors and ancillary areas.
