Mikimoto Kōkichi was able to use Nishikawa's technology. After the patent was granted in 1916, the technology was immediately commercially applied to akoya pearl oysters in Japan in 1916. Mise's brother was the first to produce a commercial crop of pearls in the akoya oyster. Mitsubishi's Baron Iwasaki immediately applied the technology to the South Sea pearl oyster in 1917 in the Philippines, and later in Buton and Palau. Mitsubishi was the first to produce a cultured South Sea pearl – although the first small commercial crop of pearls was not successfully produced until 1928.
