Loop 353 begins on the southwest side of San Antonio at I-35 just northeast of I-410 interchange. The loop heads northeast along New Laredo Highway, roughly paralleling the interstate for its entire routing. The road continues towards the northeast, intersecting Loop 13 (Military Drive). The highway is the southeast boundary and provides access to Kelly USA, the former Kelly Air Force Base. At an intersection with Zarzamora Street, the street name changes to Nogalitos Street. The highway continues to the northeast and has a junction with US 90 just prior to its northern terminus at I-10 and I-35.
