The 49ers were the top seed in their conference, winning a tiebreaker with the Packers and New Orleans Saints due to head-to-head records. This was the first time the 49ers obtained home field advantage throughout the playoffs since the 1997 season. In the playoffs, the 49ers defeated the Minnesota Vikings in the Divisional Round and the Packers in the NFC Championship Game, advancing to Super Bowl LIV, their first championship appearance since the 2012 season. However, the 49ers lost Super Bowl LIV to the Kansas City Chiefs 31–20. Despite having a 20–10 lead heading into the fourth quarter, the 49ers suffered their second Super Bowl loss in franchise history. It was the first time the 49ers lost a Super Bowl when leading after the third quarter (previously 4–0). The Niners also failed to join the Pittsburgh Steelers and New England Patriots as the only franchises to win 6 Super Bowls, or win their first title in 25 years.
