US 127 intersects US 6, the Grand Army of the Republic Highway and with State Route 15 (SR 15) becomes Main Street in Bryan. At the northern city limit, SR 15 continues north to the Ohio Turnpike while US 127 begins a northeast route toward West Unity. After passing under the turnpike, US 127 has a brief concurrency with US 20 and then enters Michigan to the north in rural Lenawee County.
