When it debuted in 1937, SR 576's routing occupied the portion of its existing alignment between its present southern terminus at SR 2 southwest of Bryan and its eastern junction with SR 107 in Montpelier. At that time, the current stretch of SR 576 between the western SR 107 junction and the eastern US 20 intersection was included as a portion of US 20A, while the stretch between US 20 and the Michigan state line was designated as SR 571.
