Irene was born around 1218, the second daughter of the megas domestikos Andronikos Palaiologos and Theodora Angelina Palaiologina. Around 1240, she married John Kantakouzenos Komnenos Angelos, who died some time before 1257. After her husband's death, Irene became a nun and assumed the monastic name Eulogia. It is not known when exactly this happened, but she was a nun by 1261.
