In 1981, Senanu was appointed pro-vice chancellor of the University of Ghana and served until September 1983, when he assumed the role of acting vice chancellor of the university. Senanu was Chairman of the Committee of Vice-Chancellors (now Vice Chancellors Ghana) for the 1983/84 academic year, as acting vice-chancellor of University of Ghana. He was replaced as pro-vice chancellor in 1983 by mathematician Daniel Afedzi Akyeampong and in 1985 as acting vice chancellor by law professor Akilagpa Sawyerr.
