After winning the coin toss, New England kicked off. The Bears punted on their first drive, while the Patriots scored on their first possession with Brady's six-yard touchdown pass to Gronkowski. The Bears would punt on their next two drives, while the Patriots scored on their following drives in the second quarter, with Stephen Gostkowski's 23-yard field goal and Brady's one-yard touchdown pass to Tim Wright. On the Bears' ensuing possession, Jay Cutler's pass for Martellus Bennett was intercepted by Devin McCourty, though it would be nullified by Brandon Browner's illegal contact penalty. The Patriots would score three times in 57 seconds: with 1:52 left in the second quarter, Brady threw a two-yard touchdown pass to Gronkowski; the Bears punted on the next drive, the Patriots returning it 42 yards to the Bears' 19-yard line, and a holding penalty on Trevor Scott moved the ball to the nine, where Brady threw a touchdown pass to Brandon LaFell with 1:07 remaining. On the Bears' next play, Cutler fumbled, and Rob Ninkovich recovered, scoring on the 15-yard return with 55 seconds left in the half. The Bears' final drive of the half ended with Cutler's pass for Brandon Marshall being intercepted by Darrelle Revis at the Patriots' five-yard line. On New England's first drive of the second half, they extended the lead to 45–7 with Brady's 46-yard touchdown pass to Gronkowski. After the Bears failed to convert on 4th-and-10 from the Patriots' 26, the Patriots were forced to punt for the first and only time in the game. The Bears would score on the following possession with Cutler's 20-yard touchdown pass to Bennett, followed by a two-point conversion pass to Dante Rosario being completed. The Patriots' next drive would last into the fourth quarter, and ended with Gostkowski's 27-yard field goal. Chicago would then score on their following drive with Cutler's ten-yard touchdown pass to Alshon Jeffery, followed by Cutler's two-point conversion pass to Matt Forte, decreasing the deficit to 25 points. Patriots' backup quarterback Jimmy Garoppolo substituted for Brady on their next drive, and five plays later, Lamarr Houston sacked Garoppolo, his first sack of the year. However, when he was celebrating, Houston tore his ACL, and would be out for the rest of the season. Gostkowski would kick a 39-yard field goal to make the score 51–23. Jimmy Clausen replaced Cutler on the Bears' last drive, ending with the Bears failing to convert on 4th down. Garoppolo would kneel once to end the game.
