Temple Houston is based loosely on the career of the real-life circuit-riding lawyer Temple Lea Houston (1860–1905), son of the more famous Sam Houston. Little, however, binds all the episodes together under a common framework. The series variously cast the characters and situations in both an overtly humorous and a deadly serious light. Author-historian (and attorney) Francis M. Nevins asserts of the first episode entitled "The Twisted Rope", "Clearly, the concept here is Perry Mason out West", going so far as to note that Temple Houston's court opponent "apes Hamilton Burger by accusing Houston of 'prolonging this trial with a lot of dramatic nonsense'". Later episodes turned Houston into more of a detective than a lawyer. Over the course of the series, the bulk of the narrative sees Houston actually gathering evidence, rather than trying cases. In the end, the series largely eschewed criminal law in favor of overtly humorous plots, such as in the episode "The Law and Big Annie", in which Houston uses his legal expertise to help a friend decide what to do after he inherits an elephant.
