The cathedral was built during the tenure of Bishop Francis Moylan. Construction began in 1799 on the site of a former church built in the 1730s. The cathedral was dedicated on 22 August 1808 by Archbishop Thomas Bray of Cashel. In his sermon, coadjutor bishop Florence McCarthy D.D. spoke of the "necessity of social worship, arguing the point from reason, scripture, and tradition." McCarthy died of typhoid in 1810, contracted while visiting a sick parishioner.
