When Spain regained East Florida in 1784, don Juan Sánchez purchased the house. He was a master caulker of the Royal Works. He also added on to the property, adding a second floor and a detached kitchen. (Juan Sánchez later also bought another property on St. George Street, the Pellicer-De Burgo House, to rent out). During Sánchez's ownership, the Royal Treasury occupied a part of the house. James Lisk bought the De Mesa-Sánchez House in 1835. He connected the kitchen to the rest of the house, covered the coquina in stucco, and painted the house pink.
