When Natalia's condition worsened, the work of accompanying the president was carried out by her daughter Hortensia, which became the official replacement for the first lady. During the last day of Plutarco Calles's presidency of Mexico in 1927, Natalia Chacón Amarillas fell very ill with a pulmonary embolism and was transferred to a hospital in Los Angeles, California, where she underwent surgery on 23 May but couldn't cope with the disease and died on 2 June due to a gallbladder complication.
