Newcastle was recommissioned and served under the command of Captain Ellis Brand in the West Indies from 1734 until 1736. She was recommissioned under the command of Captain Edward Baker in May 1738, serving in the Mediterranean into 1739. She was under the command of Captain T. Fox from October 1739, serving in the Channel until 1742, then in the Mediterranean until 1744. In April 1745 she was under the command of Captain J. Watkins in the Channel.
