Two known motifs were found in the human ERICH2 protein. The KKNT motif functions in cAMP- and cGMP- dependent protein phosphorylation, this protein motif was found only in primates. There is also a FGRR motif conserved in mammals that is defined as an amidation site. Finally the ERICH2 protein contains the PHA03247 domain that is 32 amino acids long. This domain is not generally conserved through orthologs and the function is unknown. It is present in the proteins that make up the herpes virion.
