Beginning in the Santonian, near the end of the MKH, the global climate began to cool, with this cooling trend continuing across the Campanian. This period of cooling, driven by falling levels of atmospheric carbon dioxide, caused the end of the MKH and the transition into a cooler climatic interval, known formally as the Late Cretaceous-Early Palaeogene Cool Interval (LKEPCI). Tropical SSTs declined from around 35 °C in the early Campanian to around 28 °C in the Maastrichtian. Deep ocean temperatures declined to 9 to 12 °C, though the shallow temperature gradient between tropical and polar seas remained. Regional conditions in the Western Interior Seaway changed little between the MKH and the LKEPCI. Two upticks in global temperatures are known to have occurred during the Maastrichtian, bucking the trend of overall cooler temperatures during the LKEPCI. Between 70 and 69 Ma and 66–65 Ma, isotopic ratios indicate elevated atmospheric CO2 pressures with levels of 1000–1400 ppmV and mean annual temperatures in west Texas between . Atmospheric CO2 and temperature relations indicate a doubling of pCO2 was accompanied by a ~0.6 °C increase in temperature. The LKEPCI lasted into the Late Palaeocene, when it gave way to another supergreenhouse interval.
