Romulo ran for a seat in the Senate during 2016 election under the Partido Galing at Puso, a coalition of senators, Grace Poe and Francis Escudero, for presidential and vice-presidential election, and their line-up for Senate election. He filed his Certificate of Candidacy (COC) at the Commission on Elections office in Palacio del Gobernador, Intramuros, Manila on October 14, 2015. He said he aims to create a “strong middle class” by promoting higher education and lowering income tax rates. He was also endorsed by Davao City Mayor Rodrigo Duterte, who won the presidential election. Romulo, however, didn't win the race and was ranked 22nd on the tally. His sister, Mons, who ran in Pasig's at-large congressional district and lost to Richard Eusebio, said in her Instagram post that their family will remain a helping hand in Pasig and the country despite losing the elections.
