Uwame rose to prominence in 2010 as a contestant on the celebrity edition of Nigerian reality TV series Gulder Ultimate Search. Prior to entering the show, she had worked on her second studio album The Woman in Question, that would be released a day after her eviction. "Amebo" and "African Juice" were the two singles released from the album. Uwame had also collaborated with artists and producers such as Samini, VIP, OJB, Cobhams Asuquo and Terry G, among others. In 2009, she was nominated for four awards at the 3rd Nigerian Music Video Awards. In early 2012, Uwame started work on a new album called Motherland and has since released singles "Port Harcourt Is Back", "African Woman Skilashy" and "Jikele". As an actress, she starred in the Nollywood films Last Dance (2006), Solid Affection (2008), Secret Code (2011), and The Code (2011). Among her accomplishments are numerous titles and honours such as, Oonyon 1 of Upata Kingdom, Queen of African music, Pop Queen, and Mrs. Ngor-Okpala.
