Intrepicalcin stabilizes the opening of RyR1 and brings it into a reversible and long-lasting subconductance state. This subconductance state is 55% of the full conductance state of the channel and enables a constant calcium release from the sarcoplasmic reticulum. The precise binding site of intrepicalcin on RyR1 is not known. However, imperacalcin is known to bind a site within the ion conduction channel. Since all known calcins induce the same modifications, a common binding site seems likely. Intrepicalcin and calcins in general are able to cross the plasma membrane and can thus translocate between cells.
