In 1967, he was elected and became the Head of the first Internal Dosimetry Laboratory in USSR that was in . Valentin Khokhryakov had created the laboratory in a short time, participated in the development and creation of a hardware and methodological complex for measuring fission fragments and actinides in the human body in the Experimental Department and in Clinic of professional radiation pathology. During his work, he has developed the basic principles and outlined ways to solve many problems of internal dosimetry. He has created and developed a dosimetric control system for personnel of the entire nuclear industry. He has developed a computational model based on an original system for estimating the solubility of aerosols of transuranic nuclides.
