The 2022 team finished the season with a 42–22 record and a 15–9 record in the Big 12. In the 2022 Big 12 Conference baseball tournament, the fourth-seeded Cowboys made a run to the semifinals where they fell to fifth-seeded Texas in Game 7, 2–9. They earned an at-large bid into the 2022 NCAA Division I baseball tournament, where they were seeded seventh overall and the top seed in the Stillwater Regional. There, the Cowboys were eliminated by second-seeded Arkansas.
