Previous cases of black grain mycetoma caused by E. jeanselmei were clinically treated and cases of phaeohyphomycosis caused by this fungus were completely cured where both cases were remedied by administering itraconazole. E. jeanselmei also showed some susceptibility to being treated with antifungal agents such as amphotericin B, voriconazole and posaconazole. Amphotericin B used to be the most potent antifungal treatment for severe fungal infections, but due to its strong association with severe side effects such as nephrotoxicity, its use is now often replaced with azoles and echinocandins. The use of combinations of surgical excision and pharmacological treatments for severe infections is usually the preferred way to treat diseases caused by this fungus.
