Since 2006, the institute's Project FDA has asserted that with modern medicine "on the cusp of a radical transformation" due to breakthroughs in precision medicine, the FDA "has struggled to adapt its regulations to new scientific advances". Senior fellows Paul Howard, Peter Huber, and Tom Coburn have all argued that the FDA could speed up approvals without sacrificing safety. In October 2015, the institute ran a full-page advertisement in the New York Times, reading, "Everyone will be a patient someday". The ad included the signatures of over a dozen industry leaders, all in support of the passage of the 21st Century Cures Act, which was signed into law by President Obama just over a year later, in December 2016.
