In bacteria, small RNAs are involved in gene regulation. Jorth et al. identified 9 sRNA by Northern blotting from computer-predicted candidates in strain VT1169 and 202 sRNA by RNA seq in strain 624. A systematic screen by RNA-seq and RT-PCR in HK1651 strain (a clinical isolate from an aggressive periodontitis patient), quantified 70 sRNAs and further identified 17 differentially expressed sRNAs during growth phases. Target prediction indicated possibility of sRNA interaction with several virulence genes. This study confirmed the presence of one of previously identified Fur regulated sRNAs JA04 identified in strain HK1651.
