The IMSI may be used in cases with high levels of DNA fragmentation, high levels of sperm aneuploidy, or if there is more than 90% of abnormal forms found in the sperm. It can only be used if the egg quality is deemed normal. It is used in cases where men have severe cases of oligozoospermia, asthenozoospermia or teratozoospermia, and where the couple repeatedly has had early abortions or have a history of miscarriage, or if they have had previous ICSI fertilization failures.
