In early 2006, LaVere released her debut album This World Is Not My Home on indie label Archer Records to instant national acclaim. She was joined on her album by many accomplished artists, including southern bluesman Jimbo Mathus, formerly of the Squirrel Nut Zippers. The Los Angeles Daily News raved at the time, "Something like this doesn't come along every day." LaVere also began a nascent acting career starting with her cameo as Rockabilly queen Wanda Jackson in Walk The Line and continued with featured role in Craig Brewer's Black Snake Moan.
