Palazzina Vincenti was designed by Gustavo R. Vincenti, a prominent Maltese architect, as his personal residence. It has been described as the epitome of his own architectural development, in which he embraced the Modernist style as opposed to Art Nouveau and Art Deco which had influenced his earlier works. It was constructed in 1948, and Vincenti lived in the building until his death in 1974. The architect's son, Hilaire Vincenti, subsequently lived there until his own death in 2019.
