U.S. Route 54 runs east–west across the reservoir's southwestern arm and then generally northeast–southwest along its eastern shoreline, crossing the southeastern arm at Osage Beach and crosses the Grand Glaize Bridge. Missouri Route 5 runs generally north–south along the lake's western shoreline, crossing the main channel at Hurricane Deck. Missouri Route 7 runs generally northwest–southeast to the lake's southwest, crossing the southwestern arm. Missouri Route 134 runs southeast from U.S. 54 north of Osage Beach to its southern terminus in Lake of the Ozarks State Park. Route 42 connects to Route 134 and US 54 in Osage Beach. Route 242 connects US 54 to near Village of Four Seasons. In addition, a network of supplemental state routes provides access to various points along the lake shore.
