Brennan confronts Angela and asks her if she is considering leaving the Jeffersonian. Angela confides to her that this job is difficult for her and she is not sure what she is going to do. Zack is also having trouble working on such "small" remains so Brennan advises him to pull back emotionally from the case. When Brennan finds a hereditary genetic defect on Charlie's bones, Booth and Brennan confront Margaret with this information and learn that she is not Charlie's biological mother as she claimed.
