Srinivasan worked in Vellore in 1953, and travelled to England in 1954. From 1954 to 1958 he worked in Hospitals in Birmingham, North Wales and London. He was later married in London in 1957. In 1959, he returned to India and joined Kasturba Medical College, Mangalore, and worked in Government Wenlock Hospital, Mangalore, Karnataka. His work with leprosy began there. In 1962, he became a full-time orthopaedic surgeon in Central Leprosy Teaching and Research Institute(CLTRI) in Chengalpattu, formerly Chingleput. After retiring from the Central Leprosy Teaching and Research Institute, He worked as a research consultant at the Portland Hand Surgery & Rehabilitation Centre in Portland, Oregon United States from 1984 to 1986, focusing on carpal tunnel syndrome. He became a member of the WHO Expert Advisory Panel for leprosy in 1985
