Many other tribes attempted to revolt against their colonial rulers. The Wayuu along the Venezuela-Colombia border had never been very subjugated by the Spanish and between 1701 and 1769 there were six rebellions, during which the Wayuu became famous for their use of firearms and horses in battle. Luis Angel Arango Library: The Guajira rebellion In 1769, the largest of these, there were as many as 20,000 Wayuu under arms. In the south, another major revolt, the 'War of the Seven Reductions', occurred in 1754, when the Guarani tribes rose up against Spanish-Portuguese rule. The Guarani lived along the contested border in South America; when the colonial powers decided to redraw the boundaries at the Treaty of Madrid, the decision was taken to relocate the Guarani. Led by Sepé Tiaraju, the Guarani fought to avoid removal from 1754-6, ultimately being defeated by the combined forces of Spain and Portugal.
