In the NCOP, she served on several Ad-hoc committees. She also co-chaired the Ad-hoc committee on the National Youth Development Agency. Mazibuko was a chair of the Women's Caucus and deputy chief whip. In May 2010, she was elected to the provincial executive committee of the ANC in Gauteng. She is the former ANCWL Gauteng Deputy Secretary and current ANCWL Gauteng Chairperson.
