Gražinytė-Tyla was born in Vilnius, Lithuania. Her father, Romualdas Gražinis, is a choir conductor affiliated with the Aidija Chamber Choir in Vilnius. Her mother Sigutė Gražinienė is a pianist and singer. Her grandmother Beata Vasiliauskaitė-Šmidtienė was a violinist. Her great-uncle was an organist, and her great-aunt was a composer. The oldest of three siblings, her sister Onutė Gražinytė is a pianist, and she has a younger brother, Adomas Gražinis.
