He was initially engaged to Ludwika Karolina Radziwiłł but the marriage never materialized. On 25 March 1691 Jakub Ludwik married Hedwig Elisabeth Amelia of Neuburg (1673–1722), the daughter of the Elector Palatine Philip William. In celebration of their wedding the opera Per goder in amor ci vuol costanza was created by librettist Giovanni Battista Lampugnani and composer Viviano Augustini. The couple had five daughters, two of whom would have progeny. As part of his wife's dowry, he received the Principality of Oława.
