Empress Irene died on 16/17 August 1324 with no surviving child. Theodora Palaiologina, sister of Andronikos III, married the new tsar Michael Shishman of Bulgaria in 1324. Andronikos III, then a widower, married Anna of Savoy in October 1326. In 1327 she gave birth to Maria (renamed Irene) Palaiologina.
