Wynne ran for re-election to the Arkansas Supreme Court in the May General election. Wynne was the top vote getter in the three-way race against Chris Carnahan and David Sterling, garnering 49.5% of the vote. A Two-round system run-off election occurred on November 8, 2022 between Wynne and Carnahan, who garnered 28.8% of the general election vote. Wynne won the run-off election with 58.4% of the vote. Wynne's second term on the Arkansas Supreme Court ends in 2030.
