The COVID-19 pandemic in Central Luzon is part of the worldwide pandemic of coronavirus disease 2019 () caused by severe acute respiratory syndrome coronavirus 2 (). The virus reached Central Luzon on March 9, 2020, when the first case of the disease was confirmed in San Jose del Monte. All provinces in the region have recorded COVID-19 cases. As of August 14, 2022. Central Luzon has 376,747 cases with 6,995 deaths.
