Since 2000, EDRN has established a national infrastructure to support validation of cancer biomarkers through innovative research and technology approaches. EDRN supports validation of some of the most promising proteomic and genomic markers evaluating their results for continued research. The biomarkers must be reliable and repeatable in testing; highly sensitive and specific; quantitative; readily obtained by non-invasive methods; part of the causal pathway for disease; capable of being modulated by the chemopreventive agent; and have high predictive value for clinical disease.
