Her drama What Every Girl Should Know, about girls at a Catholic girls school around 1914 who worship birth control and women's rights activist Margaret Sanger, was performed in Durham, Berkeley, and New York. The title of the play is drawn from the name of Sanger's sex education column in the New York Call, published in 1912 and 1913. Robert Hurwitt of the San Francisco Chronicle remarked that "Byrne's often clever, provocative script isn't fully fleshed out" and "the swift pacing doesn't make up for how thinly Byrne has developed her story or characters". Pat Craig of the San Jose Mercury News praised the "often lighthearted banter and genuine humor that makes the piece float and deliver some powerful messages without sounding the least like proselytizing".
