Kilomé signed with the Philadelphia Phillies as an international free agent in 2013. He made his professional debut in 2014 with the Gulf Coast Phillies where he posted a 3.12 ERA in 40 innings pitched. He pitched in 2015 for the Williamsport Crosscutters where he posted a 3–2 record with a 3.28 ERA in 11 starts. Kilomé spent 2016 with the Lakewood BlueClaws, pitching to a 5–8 record and 3.85 ERA. in 23 games started. Kilomé began 2017 with the Clearwater Threshers, and after posting a 6–4 record and a 2.59 ERA in 19 starts, was promoted to the Reading Fightin Phils where he finished the season, going 1–3 with a 3.64 ERA in five starts. The Phillies added Kilomé to their 40-man roster after the 2017 season. He began 2018 with Reading.
