Two music videos for the single were released. The first video features Kesha and her friends on a distant planet, dancing around in a mosh pit while slowly turning into stardust as the video progresses. The inspiration for the video, according to Kesha, was about shedding your inhibitions and being "raw and real." The second video released for the song features Jeffree Star and incorporates a more dominant animal theme, while drawing from 80s themed inspiration such as: Tron, David Bowie in Labyrinth, and Revenge of the Nerds. To promote the single Kesha performed "Take It Off" alongside earlier singles "Your Love Is My Drug" and "Tik Tok" on NBC's Today.
