The veteran character actor Ed Begley co-starred as Sgt. O'Hara, and the supporting cast included Betty Garde, Paul Stewart, Linda Watkins, Mary Patton as Lila North and Vicki Vola, who was also the female lead in Mr. District Attorney. Amzie Strickland played Runyon's girlfriend Cathy Evans, and Nell Harrison was Runyon's mother during the early episodes. The cast also included Dan Ocko, Rolly Bester (wife of science fiction writer Alfred Bester) and Robert Dryden. An 11-piece orchestra was directed by Bernard Green, who also wrote the program's theme. The sound effects were by Ed Blaney, and the announcers were Charles Irving and sportscaster Gene Kirby (1909-1985).
