In June 2018, Deportivo Cali organized their first "Women's Football Festival", aiming to recruit any potential players. In this event, matches and competitions between the club's satellite teams as well as the club's already existent women's football academy were held. The Carlos Sarmiento Lora football school also contributed to the formation of the women's squad. The team's participation in the Colombian Women's Football League was confirmed on 23 May 2019, whilst the women's team was officially presented on 10 July and three days later played its first game in the professional league, defeating Atlético F.C. by a 3–1 score.
