PA 68 enters the borough of Zelienople in Butler County and becomes West Beaver Street, heading into residential areas. The road curves east and reaches an intersection with US 19, where PA 68 turns north to join that route on South Main Street, passing through the commercial downtown. The road intersects the eastern terminus of PA 288, where it becomes North Main Street, before PA 68 splits from US 19 by heading east on East Grandview Avenue. The route runs past homes, crossing into the borough of Harmony and becoming Evans City Road. PA 68 heads through residential and commercial areas a short distance to the south of Connoquenessing Creek and the P&W Subdivision railroad line, which is owned by CSX and operated by the Buffalo and Pittsburgh Railroad. The roadway crosses into Jackson Township and becoming a four-lane divided highway as it comes to an interchange with access to and from the southbound direction of I-79. The road becomes two lanes and undivided again as it continues southeast into wooded areas with some development, passing through Eidenau and Harmony Junction. The route continues to the southwest of the railroad tracks and Breakneck Creek, reaching an intersection with PA 528.
