Signed by the San Diego Padres in 2005 for $1 out of a tryout camp, Breslow excelled, getting $1,500 after making the Double-A Southern League Mobile BayBears, allowing a .212 average in 52 innings over 40 outings while striking out 47 and walking 17 with a 2.75 ERA. He earned his first big league callup on July 23, 2005. He was mistaken for the team batboy during his first day with the Padres. Breslow became the 24th Yalie to play in Major League Baseball and the first to reach the major leagues since Ron Darling. "It wasn't until I was playing baseball in the big leagues that I thought I could play baseball in the big leagues", he said.
