On 6 February 2022, Minamino scored in a 3–1 win against Cardiff City in the FA Cup fourth round, and two goals in the fifth round to take Liverpool to the quarter-finals. Liverpool went on to win the competition on 15 May by defeating Chelsea in the final, which ended in a 0–0 draw after extra time and Liverpool winning 5–6 in the penalty shoot-out, although Minamino was not named in Liverpool's matchday squad.
