The series revolved around a group of nurses working at the same Miami hospital as Empty Nests Dr. Harry Weston. Initially, the main characters were strong-willed nurse Annie Roland (Arnetia Walker), sarcastic nurse Sandy Miller (Stephanie Hodge), dim-witted nurse Julie Milbury (Mary Jo Keenen) and Latina nurse Gina Cuevas (Ada Maris) who frequently reminisced about her homeland, the fictional San Pequeño. Also in the cast were arrogant Dr. Hank Kaplan (Kip Gilman), wise-cracking orderly Paco Ortiz (Carlos Lacamara) and flaky nurse Greg Vincent (Jeff Altman). Florence Stanley had a recurring role during the first season as Dr. Riskin.
