Mitchell was selected by the St. Louis Cardinals in the ninth round (226th pick overall) of the 1981 NFL Draft. As a 5'9", 188 lbs. running back, Mitchell played for the Cardinals from 1981 to 1989 and ended his NFL career with the Kansas City Chiefs in 1990; he made a brief comeback with the Arizona Rattlers of the Arena Football League in 1993. His best year as a pro was during the 1985 season when he rushed for 1,006 yards and seven touchdowns, while also contributing 502 yards and 3 touchdowns as a receiver. In 10 NFL seasons he rushed 986 times for 4,647 yards and scored 32 touchdowns, he has the second most all purpose yards in Cardinals franchise history with 11,985 behind only Larry Fitzgerald.
