Williams has appeared on television and also provided voice work on animated shows: in a 2001 episode of The Simpsons Serena joined the animation along with sister Venus, Pete Sampras and Andre Agassi. She has also provided guest voice work in a 2005 episode of Playhouse Disney's animated kids show Higglytown Heroes and a 2007 episode of the Nickelodeon cartoon Avatar: The Last Airbender, which she has described as her "favorite show".
