In November 2011, DeVitto was confirmed to have a recurring role in The CW fantasy drama series The Vampire Diaries as Dr. Meredith Fell, who is fascinated by Alaric Saltzman (Matthew Davis), when she notices how quickly he recovers from an injury. She portrayed Margo in the comedy-drama film Cheesecake Casserole (2012), released on July 3, 2012. In November 2012, it was reported that she had signed on to star as Maggie Hall in the seventh season of the Lifetime drama series Army Wives. Maggie Hall is a mother of two and former soldier who moves to Fort Marshall with her family. On September 24, 2013, Lifetime announced the show's cancellation, it honored the show with a two-hour retrospective special with the cast members which aired in 2014. She had a lead role as Jennie Stanton in the Hallmark Channel television film Best Christmas Party Ever in 2014.In August 2015, DeVitto signed on to star in the NBC medical drama series Chicago Med. She was cast as Dr. Natalie Manning, the ED pediatrician. She has also appeared as Dr. Natalie Manning in Chicago P.D. and Chicago Fire. DeVitto's character exited the show after six years in the season 6 finale. "All good things must come to an end. It has been such an honor and pure joy to bring Dr. Natalie Manning to life for all of you on Chicago Med for the past 6 seasons. But it is now time for me and her to bow out and say goodbye," she wrote on Instagram.
