In chemistry, the mass differences associated with the emitted energy are around 10−9 of the molecular mass. However, in nuclear reactions the energies are so large that they are associated with mass differences, which can be estimated in advance, if the products and reactants have been weighed (atoms can be weighed indirectly by using atomic masses, which are always the same for each nuclide). Thus, Einstein's formula becomes important when one has measured the masses of different atomic nuclei. By looking at the difference in masses, one can predict which nuclei have stored energy that can be released by certain nuclear reactions, providing important information which was useful in the development of nuclear energy and, consequently, the nuclear bomb. Historically, for example, Lise Meitner was able to use the mass differences in nuclei to estimate that there was enough energy available to make nuclear fission a favorable process. The implications of this special form of Einstein's formula have thus made it one of the most famous equations in all of science.
