In 2017, the Ragulator was thought to regulate the position of the lysosome, and interact with BORC, a multi subunit complex located on the surface of the lysosomal membrane. Both BORC and mTORC1 work together in activating the GTPases to change the position of the lysosome. It was concluded that BORC and GTPases compete for a binding site in the LAMTOR 2 protein to reposition the lysosome.
