On 22 June 2010, in the final match of the group stage of the 2010 World Cup, Cavani set-up a goal for Luis Suárez in a 1–0 win over Mexico. Uruguay won Group A and advanced to the knockout stage. On 10 July 2010, he scored against Germany in the third place match to make the score 1–1; Germany went on to win 3–2.
