The Sisters of the Holy Cross started Holy Cross Girls' High School near the Holy Rosary Church in 1951 as a kindergarten with two students. The next year it became a primary school. Later it was accredited by the Dhaka Board of Intermediate and Secondary Education as a secondary school serving students through class 10. The first batch of students from the school sat their Secondary School Certificate (SSC) examinations in 1966. By that time, the school had humanities and science sections. It opened a commerce section in 1999.
