Flight 759 began its takeoff from Runway 10 at the New Orleans International Airport (now Louis Armstrong New Orleans International), in Kenner, Louisiana at 16:07:57 central daylight time, bound for Las Vegas, Nevada. At the time of Flight 759's takeoff, there were thunderstorms over the east of the airport and east-northeast of the departure end of runway 10. The winds were reported to be "gusty and swirling." First officer Pierce was the pilot flying and captain McCullers was the pilot monitoring, as recorded on the aircraft's cockpit voice recorder (CVR):
