This disease is characterised by multifocal stenosing ulceration of the small intestine. The ulcers are circular or irregular in shape and their margins are always clear. The intervening mucosa appears normal. The lesions involve only the mucosa and submucosa and are confined to the jejunum and proximal ileum. Nonspecific inflammatory changes are present. Giant cells or other typical features of granulomatous inflammation are not found. Multiple stenoses are typically present (mean 8: range 1-25).
