Tshekedi was named heir by his father over his son Sekgoma II, with whom he had quarrelled, although Khama set aside the decision in 1916 when he reconciled with Sekgoma. On the death of Khama III in 1923 Sekgoma II succeeded as king, but his reign was ended by his early death in 1925. Sekgoma's heir, Seretse Khama, was still a minor, and Tshekedi was named regent for the duration of Seretse's minority. A regency council was named to assist during Tshekedi's absence at the Native College.
