He Shikai (和士開) (524–571), courtesy name Yantong (彥通), was an official of the Chinese Northern Qi. He was a close associate of Emperor Wucheng (Gao Zhan) prior to Emperor Wucheng's accession to the throne, and he became a powerful official (and lover to Emperor Wucheng's wife Empress Hu) during Emperor Wucheng's reign. He was criticized in traditional histories as a corrupt and incompetent official. After Emperor Wucheng's death, Emperor Wucheng's son Gao Yan the Prince of Langye was displeased with the authority that He Shikai was still wielding, and killed him in a coup in 571, but subsequently was himself killed.
