Cosijopii succeeded his father Cosijoeza to the throne in 1529. Cosijopii moved his capital from Zaachila city to Guiengola at some point in the mid-sixteenth century. His sister, Donají Sicasibí was kidnapped by the Mixtecos and taken to Tehuantepec. He formed an alliance with the Spanish, commanded by Pedro de Alvarado when he arrived in Tehuantepec, and together they fought the Mixtecos. According to the Catholic Encyclopedia, Cosijopii II subsequently "embraced the Catholic Faith," baptized as Juan Cortés Sicasibí.
