Between 1949 and 1989, over 4,000 uranium mines in the Four Corner region of the American Southwest produced more than 225,000,000 tons of uranium ore. This activity affected a large number of Native American nations, including the Laguna, Navajo, Zuni, Southern Ute, Ute Mountain, Hopi, Acoma and other Pueblo cultures. Many of these peoples worked in the mines, mills and processing plants in New Mexico, Arizona, Utah and Colorado. These workers were not only poorly paid, they were seldom informed of dangers nor were they given appropriate protective gear. The government, mine owners, scientific, and health communities were all well aware of the hazards of working with radioactive materials at this time. Due to the Cold War demand for increasingly destructive and powerful nuclear weapons, these laborers were both exposed to and brought home large amounts of radiation in the form of dust on their clothing and skin. Epidemiologic studies of the families of these workers have shown increased incidents of radiation-induced cancers, miscarriages, cleft palates and other birth defects. The extent of these genetic effects on indigenous populations and the extent of DNA damage remains to be resolved. Uranium mining on the Navajo reservation continues to be a disputed issue as former Navajo mine workers and their families continue to suffer from health problems.
