During the first few months of the 2016 season, a number of offensive players became unavailable due to injury including Manon Melis, Jess Fishlock and Megan Rapinoe. During the team's second game of the season, Little served two assists and scored a goal in the 79th minute to secure a 3–0 win against the Boston Breakers. The following week, she scored the lone goal of the match against FC Kansas City. Little finished the regular season with six goals and two assists. Seattle finished the regular season in fifth place with a record, narrowly missing a playoff spot by two points.
