The seat became vacant when 49-year incumbent Republican representative Don Young died on March 18, 2022. A special primary election was held on June 11, while the general election was held alongside the regular primary election on August 16. The filing deadline was on April 1. This was the first election to use the state's new voting system, approved for use with 2020 Alaska Measure 2. Under the new system, all candidates compete in a single blanket primary, with the four candidates receiving the most votes advancing to the general election, which is conducted using instant-runoff voting.
