The episode was written by Gary Janetti and directed by Greg Colton. It received mixed reviews from critics for its storyline and many cultural references, in addition to receiving criticism from the Parents Television Council. According to Nielsen ratings, it was viewed in 6.72 million homes in its original airing. The episode featured guest performances by Stephen Bishop, Mo Collins, Colin Ford, Lucas Grabeel, Anne Hathaway, Nana Visitor and Mae Whitman, along with several recurring guest voice actors for the series. "Go, Stewie, Go!" was released on DVD along with ten other episodes from the season on December 13, 2011.
