SR 53 heads north from the southern terminus at U.S. Route 231 (US 231), concurrent with Broadway. The road is two-lane highway passing through a farmland with residential house. The highway becomes a four-lane divided highway, still passing through a mix of farmland and residential, at 93rd Avenue. As the route enters Merrillville the farmland and residential turns into commercial properties. In Merrillville the road has a traffic light at US 30. North of US 30 the road becomes a for-lane undivided highway with a center turn lane as it passes through commercial properties. At 73rd Street the route begins to enter a more residential area with few commercial properties. The highway crosses a set of railroad tracks on the north side of Merrillville. North of Merrillville the road enters Gary and passes through a mix of residential and commercial properties, staying as a four-lane undivided highway with a center turn lane. The road crosses a signal railroad track and has a traffic light at Ridge Road (old US 6). North of 33rd Avenue the road becomes a four-lane undivided highway without a center turn lane, as the road passes through a mostly wooded area. The route has an interchange with Borman Expressway (Interstate 80 (I–80) and I–94). The highway heads north towards downtown Gary passing three single track railroad crossings. In downtown Gary the route has an intersection with the one-way streets of Fifth Avenue, eastbound US 12/US 20 and Fourth Avenue, westbound US 12/US 20. North of Fourth Avenue the road passes under the Shore Shore line, a Commuter rail line. After passing the South Shore line the highway has an interchange with the I–90/Indiana Toll Road. This interchange is the north terminus of SR 53, but Broadway continues north passing under three sets of railroad tacks. Broadway ends at a security gate for the main entrance of Gary Works owned by U.S. Steel.
