Iowa played their final game of the season on November 19 in Evanston. Northwestern had already beaten DePaul but the Purple had lost their other five games by a combined score of 106–0. The Hawkeyes handed Northwestern their sixth shutout loss of the season, winning 14–0. The victory gave Iowa its first perfect season and outright Big Ten championship. The Hawkeyes never trailed in 1921. Aubrey Devine and Gordon Locke finished first and second in the Big Ten in scoring, respectively.
