As a rule, treatment of cancer focuses on a two-step approach: tumor debulking by conventional and innovative modalities, followed by immunotherapy of minimal residual disease. As such, innovative reduced intensity conditioning (RIC) or non-myeloablative stem cell transplantation (NST) were pioneered by Slavin for safer stem cell transplantation for treatment of malignant and life-threatening non-malignant disorders correctable by using stem cells and post-transplant immunotherapy if indicated for all patients in need. The use of RIC or NST made it possible to apply much safer curative stem cell transplantation for every patient in need with no lower or upper age restriction, including also patients with less than optimal clinical condition that would not be eligible for the standard myeloablative stem cell transplantation.Slavin S, Napier A, Naparstek E, Kapelushnik J et al., Non myeloablative conditioning in preparation for allogeneic stem cell transplantation: the future treatment of choice of hematologic malignancies and genetic diseases, ResearchGate
