Bradley described the book as a well-written account of the process of science. She commented that more work needed to be done to replicate Hamer's research and identify the relevant gene, but credited Hamer with being "cautious in extrapolating his findings to larger issues" and acknowledging the limitations of the research. However, she wrote that despite his caution, Hamer used the term "gay gene" in a misleading fashion, since "the term implies more than Hamer's work establishes." She also commented that, "the least well thought out and presented part of this book is the section on psychological theories", which she considered understandable given that Hamer is "not trained in psychology or psychiatry". In her view, "even its subtitle, “Sissies, Freud, and Sex Acts,” suggests a hasty dismissal of the importance of psychological theories." She concluded that the book, "makes enjoyable reading, particularly for anyone interested in the making of science as it relates to human behavior or sexuality."
