On December 30, 2019, the Chicago White Sox signed Keuchel to a three-year, $55.5 million contract. He made his White Sox debut on July 25, 2020, picking up a win over the Minnesota Twins. In the 2020 season, he was 6–2 with a 1.99 ERA. He led the AL in fewest home runs per 9 IP (0.284), and in fewest strikeouts per nine innings (6.0).
