Lord Sherard was married to Abigail (née Cave) Tresham (1593–1659), widow of Henry Tresham of Newton, eldest daughter and co-heiress of Anne (née Bennett) Cave (daughter of sole heir of Anthony Bennett of Greenwich) and Cecil Cave of Stanford (third son of Roger Cave). Together, they were the parents of seven sons (four of whom died without unmarried) and four daughters (three of whom died unmarried):
