On 31 October 2020, Perišić scored his first goal of the season for Inter Milan in a 2–2 home draw against Parma. On 3 November, he scored his first Champions League goal for Inter Milan in a 2–3 defeat against Real Madrid. During the spring part of the season, Perišić was praised by Conte for successfully adapting to his system, moving from the position of a winger to that of a wing-back.
