A depleted Munster squad made up of internationals who'd been away with Ireland during the Autumn tests, academy players and members of the national and provincial talent squads travelled over to England to face Wasps on their opening Champions Cup fixture on 12 December 2021. The team, which featured 12 debutantes, pulled off one of the great Munster away victories, defeating their opponents 35–14 in a thrilling contest in front of a large contingent of Munster fans who had made the journey to Coventry.
