Ludlow repaired at New York, then trained along the Atlantic coast and returned to the Mediterranean 20 April for antisubmarine patrols. On 19 May, Ludlow and Niblack depth charged to the surface, where Ludlows main battery sank her. After convoy alignments in the western Mediterranean, Ludlow steamed 11 August from Palermo for the invasion of southern France. Following preinvasion bombardment and beachhead screening off Fréjus, she joined Augusta from 25 to 30 August to help overcome the last resistance at Marseilles. While on coastal fire support missions around Monaco, she encountered not only floating mines and E-boats, but also attacks by explosive-laden boats and human torpedoes. Ludlow captured three operators of these one man diving machines on 5 September after a series of depth charge attacks. Fire support, convoy and patrol duty continued until 23 January 1945, when Ludlow sailed for a month's plane guard duty off the west coast of Africa, returning to Boston on 28 February. In April she sailed to England to escort a convoy of LSTs stateside, then prepared for duty in the Pacific.
