Purdue lost to Northwestern, 31–27. Northwestern scored 14 points in the first quarter via a 1-yard touchdown run from Jeremy Larkin and a 2-yard touchdown run by John Moten IV. Purdue responded with 14 points in the first quarter via a 32-yard touchdown pass from Elijah Sindelar to Rondale Moore and a 76-yard touchdown run by Moore. Northwestern regained its lead in the second quarter via a 34-yard field goal by Charlie Kuhbander and a one-yard touchdown run by T. J. Green. Purdue responded with a 38-yard Spencer Evans field and the final score of the first half came on a 4-yard run by Larkin, which made the score 31–17 in favor of Northwestern at half-time. Purdue added a 2-yard touchdown run by D. J. Knox in the third quarter. Purdue reduced Northwestern's lead to four points following a 27-yard field goal from Evans in the fourth quarter.
