Devereux became acquainted with the family of Dr.Benjamin Butler (a surgeon) on his business trips to New York. He married their daughter Mary Dolbear Butler on November 28, 1817. They had six children. His daughter Hannah married United States Senator Francis Kernan; his daughter Mary became a Sister of Mercy and laboured for thirty years in the convents in Houston and 81st streets, New York. His son, John C. Devereux, assisted in managing his father's extensive properties. In 1831, his family was subject to a dangerous case of influenza. While it appears that the members of the Devereux household survived, the attending physician, Dr. Alexander Coventry succumbed to the illness, leaving behind seven sons and four daughters.
