Main fields of scientific activity of Giorgi Tsereteli were: Arabic dialects of the Central Asia, Arabic linguistics and folklore, Hebrew and Aramaic studies, history of old languages of the Near East, history of writing systems, history of the Georgian script, source studies of the history of Georgia and the Caucasus, Rustvelology, questions of theoretical linguistics, etc. He was author of more than 100 important scientific-research works, among them 10 monographs.
