Ambrose Cave was the son of Richard Cave (see Cave-Browne-Cave baronets) and Margaret Saxby of Stanford, Northamptonshire. He was educated at Cambridge University. He was knighted by 1525. He was a Member of Parliament for Leicestershire in 1545, 1547 and 1553 and for Warwickshire in 1558, 1559 and 1563 and High Sheriff of Warwickshire in 1549. He was also Chancellor of the Duchy of Lancaster (1558–1569) and Custos Rotulorum of Warwickshire (also 1558–1568).
