On 26 July 2021, Reghecampf returned to his native Romania, where he signed a two-year contract to become the new manager of CS Universitatea Craiova. After finishing the previous season third in the league table, the team saw themselves in sixth position in December 2021, triggering rumours of his premature departure from the club. As a result, Reghecampf transfer-listed several first-team players, including Mihai Bălașa, Matteo Fedele, Antoni Ivanov and Mihai Roman. In June 2022, he stepped down as coach.
