The church was destroyed by a massive fire in 1949, known as the Great Fire of Meycauayan. Artifacts such as old memorabilia, statues, church vestments, records, ciboriums and chalices are some of the casualties of the fire. The retablo in the spanish colonial style was destroyed. Only a few church items including the tabernacle were saved from the fire. It was saved from destruction by Fr. Jorge Capistrano (currently on display at the parish museum). After its destruction, a committee was formed for the reconstruction of the present church by the priests together with Anselmo de Leon as its head, which campaigned for donations and help from the people for the church's restoration.
