The song tells the story of Tone Lōc's experiences with "Funky Cold Medina", a potent aphrodisiac in a beverage format. At the beginning of the song, Loc consults a fellow club-goer who appears to be having more success with women than Loc is. The unnamed stranger informs Loc that his success is the result of his use of the Funky Cold Medina, which makes anyone who drinks it irresistible to others (although this is later contradicted by lyrics that suggest that it makes those who drink it find others irresistible).
