The angelic acid esters of sesquiterpene alcohols, such as petasin, are the active chemical behind the strong pain-relieving and spasmolytic action of extracts from the plant butterbur. Roman chamomile, in which esters of angelic and tiglic acids are the principal components, was used as a sedative and tonic, and as a medicine against nervous problems, fever, colic, heartburn, loss of appetite, gout, headache and other health disturbances.
