Two research studiesSchuckit MA; Danko GP; Raimo EB; Smith TL; Eng MY; Carpenter KK; Hesselbrock, V. (2001). A preliminary evaluation of the potential usefulness of the diagnoses of polysubstance dependence. Journal of Studies on Alcohol, 62(1), 54-61.Martinotti G; Carli V; Tedeschi D; Di Giannantonio M; Roy A; Janiri L; Sarchiapone, M. (2009). Mono- and polysubstance dependent subjects differ on social factors, childhood trauma, personality, suicidal behaviour, and comorbid Axis I diagnoses. Addictive Behaviors, 34(9), 790-793. sought to determine if polysubstance dependence patients differ in any important ways from patients with a single-drug substance dependence but each study defined polysubstance dependence differently, making comparisons difficult.
