In DOA: Dead or Alive (2006), a British-German-American martial arts action film, Pressly starred as one of four female fighters working together to uncover the secret that the organizer of an invitational martial arts contest is trying to hide. While the film was relatively successful on some markets, it only found a limited audience in North America. In 2006, she also hosted the first annual VH1 Rock Honors, and an episode of Saturday Night Live, and guest-starred on MADtv, playing Hillary Clinton in a parody of My Name Is Earl, "My Name Is Dubya", in which George W. Bush (Frank Caliendo) makes a list of all the bad things he has done in the past and rectifies them one by one. She voiced a bird in the computer-animated comedy hit Horton Hears a Who! (2008), featuring Jim Carrey, Steve Carell, Will Arnett, among others.
