In a game affected by winds greater than 40 miles per hour, divisional rival New England ran the ball 46 times and only threw three passes, accumulating over 200 rushing yards and just 19 passing yards. The Bills also tried a run-heavy approach but relied more on the passing game late in the game despite the heavy winds affecting several of Josh Allen's passes. New England never trailed after taking the early lead with a 64-yard rushing touchdown by Damien Harris, and Buffalo finished just 1 for 4 on redzone possessions, leading to a 14–10 loss to the Patriots.
