In February, Sale sustained a right rib stress fracture while throwing batting practice at Florida Gulf Coast University. Prior to the start of the regular season, he was placed on the 60-day injured list. On July 1, Sale pitched for the Portland Sea Dogs in a rehabilitation assignment, allowing one run on four hits in four innings while striking out seven batters. During a rehab start in Triple-A on July 7, a video captured Sale destroying items in the dugout tunnel after he issued five walks and allowed one run in innings. He returned to Boston's lineup on July 12, receiving a no decision after allowing no runs on three hits in five innings. On July 17, he suffered a left fifth-finger fracture after being struck by a line drive hit by Aaron Hicks. Sale underwent surgery, involving open reduction and internal fixation, the next day. He was officially added to the injured list on July 22. On August 6, Sale broke his right wrist while riding his bicycle to grab lunch, ending his season. Chief Baseball Officer Chaim Bloom commented that the Red Sox needed to find whoever had a "Chris Sale voodoo doll", referring to his list of injuries since the 2019 season. In two starts for the 2022 Red Sox, Sale posted an 0–1 record with 3.18 ERA while striking out five batters in innings.
