The brigade participated in the First Italian War of Independence fighting in the battles of Santa Lucia, Goito, Pastrengo and Custoza. During the Battle of Goito the Sardinian King Charles Albert rallied the Grenadiers Brigade "Guardie" to his position with the words "A me le guardie!" ("To me the guards!"), which became the motto of the brigade's regiments. After the war the brigade was renamed Grenadiers Brigade () on 20 April 1850; the 2nd Hunters Regiment had already been renamed 2nd Grenadier Regiment in 1848.
