Lepchenko started her clay-court season at the Charleston Open. She was defeated in the first round by Petra Cetkovská. At Madrid, Lepchenko lost in the second round to fifth seed Petra Kvitová. Playing at the Italian Open, she was defeated in the third round by top seed, defending and eventual champion, Serena Williams. Competing at the French Open, she lost in the second round to eighth seed Angelique Kerber.
