The museum began a slow decline starting in the late 19th century, despite continued acquisition of new collections, and its upkeep became problematic. In 1937 Gustave Roussy ordered the museum shut, with many items subsequently lost or destroyed. However, in 1967 Jacques Delarue (1901–1971) brought the museum back to life with a general refurbishment. Today it still retains an extensive collection including specimens dating from the 17th century, as well as wax anatomical models, books, and photographs.
