Since its 2003 model revision, the Express has seen incremental updates to the model line. For 2008, the Express passenger van received side-curtain airbags and standard stability control (introduced for 3500-series vans for 2005); the steering wheel, seats, and gauge cluster were also redesigned. For 2011, the dashboard received upgrades (including Bluetooth compatibility and a USB port). For 2013, higher-trim passenger vans received a optional navigation system, rearview camera, and parking assist system. For 2015, all radios became digitally-tuned and a 120-volt outlet was added to the dash. For 2018, the Express dropped sealed-beam headlights from all models, adopting the four composite headlamps of higher-trim passenger vans. For 2019, higher-trim passenger vans received lane departure warning systems and collision alert warning features.
