Between 1537 and 1594, Mutěnice was owned by the lords of Lipá. From that time is documented existence of a fortress here. The lords of Lipá sold it to the Salm family, who soon sold it and the village further often changed owners. Between 1565 and 1605, a community of Anabatists settled here. The village was devastated by the Thirty Years' War. The population has declined to a quarter.
