The oral clearance (CL/F) of nirmatrelvir combined with ritonavir is 8.99 while that of ritonavir is 13.92. The elimination half-life of nirmatrelvir combined with ritonavir is (mean ± SD) 6.05 ± 1.79hours while that of ritonavir is 6.15hours. The half-life of nirmatrelvir combined with ritonavir makes the formulation suitable for twice-daily administration once every 12hours.
