Liga played the Round of 16 against Argentine club Lanús. The first leg, held in Quito, was a goal-fest for Liga. A hat-trick by Claudio Bieler and a goal by Édison Méndez gave LDU Quito a 4–0 win and a significant advantage in the next leg. The second leg, held in Estadio Ciudad de Lanús, ended in a 1–1 draw. Claudio Bieler again scored for Liga.
