Jefferies retired from boxing after his hands failed to heal following surgery attempting to address his long-term struggle with hand issues in 2012. Following his retirement, he moved to Los Angeles where he waited anticipating this healing process. Tony Jeffries started to work in a gym in Santa Monica where he met another trainer who is from Kentucky. Jefferies and his fellow trainer left this gym and started a boxing Bootcamp in Santa Monica which received investment from actor Mickey Rourke. The terms of the premises where changed by Mickey Rourke, contrary to what Jeffries and the other trainer originally agreed upon so they went separate ways. The Santa Monica Bootcamp got voted Los Angeles' number 1 gym in 2013 on Yelp and the gym Box 'N Burn was successful after just a year of opening in 2014. Jeffries and the other trainer opened Box 'N Burn's second location in Brentwood, Los Angeles. Alongside his ventures in boxing, Jefferies played a role in NBC TV's Blacklist in 2013 and was one of the figures in Levi's world campaign in the same year. His Levi's modelling pictures were on billboards across the world. Tony was also the head trainer for MMA fighter Brendan Schaub, cornering him for his bouts against Matt Mitrione, and Travis Browne, which ultimately led to Schaub's retirement. He has also featured in the video for Cannonball (Skylar Grey song). In June of 2022, Jeffries also starred in a Dhar Mann video.
