When Jacob Berab died, Karo was regarded as his successor, and together with Rabbi Moshe of Trani he headed the Rabbinical Court of Safed. In fact, by this time, the Rabbinical Court of Safed had become the central rabbinical court in all of Old Yishuv (southern Ottoman Syria), and indeed of the diaspora as well. Thus there was not a single matter of national or global importance that did not come to the attention and ruling of the Safed Beth Din. Its rulings were accepted as final and conclusive, and Karo's halachic decisions and clarifications were sought by sages from every corner of the diaspora. Rabbi Joseph Karo was also visited in Safed by the great Egyptian scholars of his day, Rabbi David ibn Abi Zimra and Rabbi Yaakov Castro. He came to be regarded as the leader of the entire generation.
