"You and Me" debuted at number 92 on the Billboard Hot 100 for the week of February 12, 2005. It stayed on the chart for 62 non-consecutive weeks, and eventually peaked at number five. On the Billboard Adult Contemporary chart, the song debuted at number 29 for the week of July 23, 2005. It eventually peaked at number one after it stayed on the chart for 34 non-consecutive weeks. The song debuted at number 29 on the Billboard Adult Pop Songs chart for the week of February 19, 2005.
