Manasco served as a law clerk to Judge William H. Pryor Jr. of the United States Court of Appeals for the Eleventh Circuit. From 2009 to 2020, she was a partner at Bradley Arant Boult Cummings in Birmingham, Alabama, where her practice focused on trial strategy and appeals in complex commercial litigation. She had represented clients before the Supreme Court of the United States, numerous federal courts of appeals, and the Supreme Court of Alabama.
