The airline was acquired in May 1936 by Thomas Fortune Ryan III, the grandchild of financier and industrial pioneer Thomas Fortune Ryan. The same year, Ryan moved the headquarters to Kansas City and Arthur S. Hanford Sr., was elected president of the new company and J. W. Bill Miller joined the company as vice president and general manager. At the time of the change in ownership, Hanford's employed 64 people, served nine cities and held route certificates that totaled 838 miles. The Ryan's only purchased six of Hanford's aircraft including two Ford Trimotors and four 4-passenger single-engine Lockheed Vegas.
