While considered overpowered for the big cats, the .416 is regularly used for the hunting of these felines. In African nations which have enforced a ban on the use of sub rifle cartridge for dangerous game, the .416 Rigby can be considered for the hunting of lion or leopard. Prior to the ban on hunting in India, the .416 Rigby was successfully used to hunt dangerous game there which included the Bengal tiger, Indian rhino, and elephant.
