As a comedian Guggenheim was part of The Groundlings comedy troupe main company. She appeared on Curb Your Enthusiasm in 2021. She had minor roles as an actress on Reno 911!, Mr. Mayor, Superstore, The Middle, Modern Family, and Splitting Up Together. She had a regular roles on Pop TV’s comedy series Florida Girls and MTV’s Mary+Jane. Guggenheim also wrote for and acted in Barely Famous and additionally, voiced Patty Mime on SuperMansion.
