The Holy Family is considered as one of Puligo's finest works. Puligo's skill with colour has again been commended in this painting: 'Upon seeing the Holy Family one is immediately struck by the bright vermillion color of the virgin's dress. This red is brought up to a light pink and is set against broad areas of gray hues forming in the background, the head of Joseph, and the shadows of the flesh. Dark blue-green is found in the Virgin's veil and mantle,which is draped across her lap.' The remarkable afflicted expression on the Christ child not only stands in contrast to the 'dreamy expression' of the Virgin in this painting, but also recurs in both Madonna and Child with St. John the Baptist and Madonna and Child with St. John the Baptist and Three Angels.
