Slaughter was drafted in the 7th round by the Denver Broncos, where he played his entire four-year career. Though he set several franchise rookie records in 1963 that stand to this day, he compiled just a 1-5-1 record as a starter. 's NFL off-season, his 1,689 yards, 15 interceptions, 7.57 yards per attempt, and 5 interceptions in a single game (Oct 13 against the Houston Oilers) remain Broncos rookie records. He started just 12 games the rest of his career, which ended at a 2-15-2 record. He had 291 completions on 584 attempts for 3,607 yards, 22 touchdowns, and 38 interceptions.
