During his time on Holby City, Nick had several romantic interests, including ex-wife and Ward Sister Karen Newburn, Theatre Sister Ellie Sharpe, SHO Kirstie Collins, and Registrars Diane Lloyd and Jac Naylor. The series homepage assesses that: "He had tremendous pulling power with women, but commitment was not his strong point." Michael French, discussing his character shortly after the show's 1999 conception, asserted that: "Like most blokes, he sometimes treats women as playthings – if they’re willing. A little bit of hanky panky is part of the human condition, after all!" Sarah Preston, who played Nick's ex-wife Karen in the first two series of the show, stated of her most memorable moments filming: "I loved my scenes with Michael, he was great to work with. Confrontation scenes give you something to get your teeth into and we had plenty of those!" Similarly, Rosie Marcel who plays Jac commented that her character and Nick "have some really bad history between them. [...] They've worked together before and Jac knows Nick will tread on anyone's toes to get to the top. It makes for some great fight scenes." Nick's series eight relationship with Diane ended, again acrimoniously, when she was blamed for a mistake he had made in theatre and refused to own up. Patricia Potter, who plays Diane, explained that when confronted; "[Nick] violently pins her against the wall and warns her never to cross him. She finally sees his other side and is devestated [sic]. Her dreams come falling down around her ears."
