On November 2, Siakam recorded his fifth career triple double with 22 points, 10 rebounds and 11 assists in a 143–100 blowout win over the San Antonio Spurs. On December 21, Siakam scored a career-high 52 points in a 113–106 win over the New York Knicks. This was tied for the second-most points in a game by a Raptors player. On December 26, Siakam was named Eastern Conference Player of the Week for Week 10 (December 19–25), averaging 38.7 points, 10.3 rebounds and 7.3 assists. Siakam initially became the first player in league history to miss out on the All-Star game while averaging 25 points , 8 rebounds and 6 assists per game . On February 10, 2023, Siakam was named an All-Star for the second time in his career as a reserve, replacing the injured Kevin Durant. On April 2, Siakam logged 36 points, seven rebounds, seven assists and two steals in a 128–108 win over the Charlotte Hornets. Siakam posted career highs of 24.2 points and 5.8 assists per game on route to having his best season off his career. In the play-in tournament Siakam scored 32 points grabbed 9 rebounds and dished out 6 assists in a 109–105 loss to the Chicago Bulls.
