Adelaide was the fifth of six children born to Prince Thomas, Duke of Genoa and his wife Princess Isabella of Bavaria. Her father was a grandson of King Charles Albert of Sardinia. Among her siblings were Ferdinando, 3rd Duke of Genoa; Filiberto, 4th Duke of Genoa; and Eugenio, 5th Duke of Genoa. Her mother Isabella was a granddaughter of Ludwig I of Bavaria.
