The Charles Scribner's Sons Building is at 597 Fifth Avenue in the Midtown Manhattan neighborhood of New York City, on the eastern side of the avenue between 49th Street to the north and 48th Street to the south. The land lot covers with a frontage of on Fifth Avenue and a depth of . Nearby buildings include 600 Fifth Avenue to the west, 608 Fifth Avenue to the northwest and Tower 49 to the east.
