The Brewers traded Diplán to the Minnesota Twins for cash considerations on July 31, 2019. Between Biloxi and the Pensacola Blue Wahoos, Diplan went 3–5 with a 4.85 ERA in innings in 2019. On September 14, 2019, the Twins designated Diplán for assignment. Diplán was claimed by the Detroit Tigers on September 16.
