Between 1970 and 1973, he progressively abandoned research on particle physics and turned his attention principally to electroacoustics and digital sound. He created a research center at the Naples University Physics Institute, where he developed numerous analog and digital systems controlled by a PDP11 computer for realtime generation and sound processing. In 1974, he met Luciano Berio, who invited him to IRCAM in Paris to create an Electroacoustic Centre; this marked the beginning of a collaboration that continued until 2000. At IRCAM, guided by the musical ideas of Pierre Boulez, di Giugno developed several prototypes of digital machines that in 1979 were consolidated in the "4X" system. This was the first entirely digital music workstation and it opened new horizons for music composition and performance. This system was used by Boulez, Nono and Stockhausen. To a certain extent it was a reference point for later digital instruments.
