The district dates back to the minor district (king amphoe) Lampam (ลำปำ), created in 1923 as a subordinate of Mueang Phatthalung District. It consisted of the two sub-districts Lampam and Han Po. On 1 November 1939 the sub-districts Lampam, Phaya Khan, and Khuan Maphrao were reassigned to Mueang District, while the sub-districts Khao Chaison and Khuan Khanun from Mueang District as well as Tha Duea and Chong Thanon from Pak Phayun were added to the minor district. The district office was then moved into Khao Chaison sub-district. In 1940 the minor district was then renamed Khao Chaison to match the central tambon. It was upgraded to a full district on 1 January 1953.
