The bypass begins in the southwestern part of the city at the intersection with US 25/US 301/SR 73, as well as US 25 Byp./SR 67 Byp. US 301 Byp., SR 67 Byp., and SR 73 Byp. travel southeast and east along the perimeter of Georgia Southern University. They follow the perimeter of the university, turning northeast towards Fair Road (SR 67), where it breaks off from the university perimeter and turns northward. Here, SR 67 Byp. ends, while US 301 Byp. and SR 73 Byp. continue. After turning north, the bypass intersects Northside Drive (US 80/SR 26), East Main Street (SR 24), and finally East Parrish Street (US 301/SR 73).
