The Mariners assigned Bazardo to the Double-A San Antonio Missions where he went 3–1 with a 4.28 ERA. In 2006, he was named Missions pitcher of the year after going 6–5 with a 3.64 ERA in 25 starts. He was also named to the Texas League post season all-star team. Over the winter Bazardo played in the Venezuelan Winter League, where he was 2–0 with a 1.78, and threw six shutout innings in the Caribbean World Series. The Mariners added Bazardo to their 40-man roster, but designated him for assignment after acquiring veteran pitcher Jeff Weaver. Rather than lose him outright, the Mariners traded Bazardo to the Detroit Tigers for outfielder Jeff Frazier on February 7, 2007.
