The Bronx High School of Science was founded in 1938 as a specialized science and math high school for boys, by resolution of the Board of Education of the City of New York, with Morris Meister as the first principal of the school. They were given use of an antiquated Gothic-gargoyled edifice located at Creston Avenue and 184th Street. The building, built in 1918 for Evander Childs High School, had been successively occupied by Walton High School (1930) and by an annex of DeWitt Clinton High School (1935). The initial faculty were comprised in part by a contingent from Stuyvesant High School. Principal Meister put his imprint on the school from its formation, for example selecting as school colors "green to represent chlorophyll and gold the sun, both of which are essential to the chain of life."
