Qureshi was born in Hyderabad, Sindh, on 11 May 1938, and received primary education in Hyderabad, combining both modern and religious studies, later on gaining a Master of Arts degree in Islamic history from Sindh University, being particularly influenced by the scholars Imdad Ali Imam Ali Kazi and Ali Muhammad Rashidi, while after his graduation he began his professional career as a host on Radio Pakistan's programme Ahsan Jo Pakistan ("Our Pakistan" in Sindhi), in 1957.Mustafa Qureshi pays rich tributes to Dr Amir for promoting education (10 January 2015), The News International (newspaper), Retrieved 3 July 2021
