In 2003, Pennetta lost in the semifinals of the Hyderabad Open to eventual champion Tamarine Tanasugarn. She also reached the quarterfinals at the Canberra Women's Classic, Copa Colsanitas, and Abierto Mexicano Telcel. She debuted in the main draws of all four Grand Slam tournaments. Her best result was the third round of the Roland Garros, where she defeated 21st-seeded American Lisa Raymond in the second round, before losing to Hungary's Petra Mandula.
