Major predators that feed on wildebeest include the lion, hyena, African wild dog, cheetah, leopard, and crocodile, which seem to favour the wildebeest over other prey. Wildebeest, however, are very strong, and can inflict considerable injury even to a lion. Wildebeest have a maximum running speed of around . The primary defensive tactic is herding, where the young animals are protected by the older, larger ones, while the herd runs as a group. Typically, the predators attempt to isolate a young or ill animal and attack without having to worry about the herd. Wildebeest have developed additional sophisticated cooperative behaviours, such as animals taking turns sleeping while others stand guard against a night attack by invading predators. Wildebeest migrations are closely followed by vultures, as wildebeest carcasses are an important source of food for these scavengers. The vultures consume about 70% of the wildebeest carcasses available. Decreases in the number of migrating wildebeest have also had a negative effect on the vultures. In the Serengeti ecosystem, Tanzania, wildebeest may help facilitate the migration of other, smaller-bodied grazers, such as Thomson's gazelles (Eudorcas thomsonii), which eat the new-growth grasses stimulated by wildebeest foraging.
