On November 5, 1955, Illinois recorded the biggest upset in the series history. Michigan came into the game with an undefeated record and ranked #1 in the UPI coaches poll, but lost to Illinois, 25–6. Bobby Mitchell led the Illini attack with 173 rushing yards on 10 carries, including gains of 75 and 55 yards. The Pantagraph wrote that Illinois outplayed Michigan in all respects and called it "one of the most cherished victories in Illinois football history."
