The first defence of her newly acquired title came four months later in December against Ana Maria Lozano. Román scored a disqualification (DQ) win in the second round after she suffered a cut on her forehead following a headbutt from Lozano in the opening round. She defeated Lozano via UD in an April 2018 rematch before defeating Duer for a second time in August via SD. Her final fight of 2018 was a six-round non-title bout against Vanesa Taborda in December at the Estadio Aldo Cantoni in San Juan. The referee called a halt to the fight in the second round after Román suffered a cut to her forehead resulting from an accidental clash of heads. The fight was ruled a no contest (NC).
