McCool was pilot of Space Shuttle mission STS-107, January 16 to February 1, 2003, logging 15 days, 22 hours and 20 minutes in space. The 16-day flight was a dedicated science and research mission. Working 24 hours a day, in two alternating shifts, the crew successfully conducted approximately 80 experiments. According to NASA, McCool said of the unique view he and his crewmates had from Columbia:
