In 2001, Caserio was hired by the New England Patriots as a personnel assistant. Caserio moved to the scouting department as an area scout in 2003. In 2004, Caserio was promoted to the Patriots' director of pro personnel, a position he served until 2006. In 2008 Caserio returned to the personnel department as the Patriots' director of player personnel. He remained in that position through the 2020 season. During Caserio's tenure with the Patriots, his position as director of player personnel did not give him final say over the roster; that power was held by Patriots head coach Bill Belichick.
