"Take Me Out" was featured in the trailer for the 2008 film Hancock and in the soundtracks of the video games Madden NFL 2005, NHL 2005, and Shaun White Skateboarding, being playable in Guitar Hero, Guitar Hero: Smash Hits, the US version of SingStar Pop, Just Dance 2, Dance Dance Revolution Universe 2 and Rocksmith. In 2017, the song was used in an advertisement for Ralph Lauren's Polo Red fragrance.
