In his early music career he formed the Latin band Santana, named after his surname. As a solo-artist he released several albums. Two of his earliest studio albums, his debut album Love Devotion Surrender with John McLaughlin and the second album, Illuminations, with Alice Coltrane, were collaborations. He then released four studio albums as a solo artist, two of which were released under his spiritual name "Devadip Carlos Santana". His latest released studio album, Santana Brothers, was a collaboration between his nephew Carlos Hernandez and his brother Jorge Santana.
