The Meksi family appeared around the 10th century and is believed to be the first branch of the Bua family. According to Milan Šufflay, the region between Cape Rodon, Kruja and Lezha was inhabited by the Messi, Meksi, Mexi family. The most distant origin must have been the village of Mesi located in the area between the rivers Shkumbin and Drin, near Shkodër. The name of the Meksi clan may originate from the function, office or position of its head, who in this particular case must have been a doctor, while the suffix "si" indicates ownership of the country. In this way, it turns out that Messi, Meksi, was a timar that a Byzantine emperor gave to the doctor, who apparently was the first head of the family.
