Critics have argued that there is evidence suggesting that the amounts of chemicals in the environment are too low to cause a significant effect. A consensus statement by the Learning and Developmental Disabilities Initiative argued that "The very low-dose effects of endocrine disruptors cannot be predicted from high-dose studies, which contradicts the standard 'dose makes the poison' rule of toxicology. Nontraditional dose-response curves are referred to as non-monotonic dose response curves."
