On a larger scale, the one to many communication of cells is typically carried out by the vascular and nervous systems. This makes detecting the contribution of hemichannels to extracellular communication more difficult in whole organisms. With the eye lens the vascular and nervous systems are absent making reliance on hemichannels greater and their detection easier. At the interface of the lens with the aqueous humor from where the lens exchanges metabolites both gap junction plaques and more diffuse connexon distribution can be seen in the accompanying micrographs.
