Cathedral records show that she was paid to create three sibyls, two angels, and a "quadro" - probably a pair of bas-relief panels, including the panel depicting Joseph and Potiphar's Wife now in the Museum of San Petronio in Bologna. In the scene, Joseph attempts to escape from the wife of an Egyptian officer. The skilfully executed musculature in combination with classical dress reveal de Rossi's knowledge of antiquity. Her style in this piece is in the "maniera moderna" of artists such as Giulio Romano, Michelangelo, Alfonso Lombardi, Correggio and Parmigianino. Additionally, the subject matter of Joseph fleeing from his temptress was a prominent subject matter in the early days of the Counter-Reformation, conveying the dangers of immorality associated with female nature. The second bas-relief panel is believed to be the Visit of the Queen of Sheba to Solomon. Vasari wrote that de' Rossi was paid "a most beggarly price for her work", attributing this to Amico Aspertini working to ruin her commissions and pay. Vasari stated that she never worked for the Cathedral again, which is supported by her absence from their records after 1526.
