On 13 December 2010, Dušan was announced the new Politehnica Timişoara's Head Coach signed for one year with option to renewal for two years. After his come back he spoke for official site : "I hope the stadium will be full again! But, above all, I promise to our fans that we play good attacking football. We hope to bring out the best place possible. I want to have the same relationship with the fans from the last time, because Poli's supporters were wonderful. I'm glad that we have again the colors that he had a team since I started coaching in 2007. These are Poli's true colors!". Uhrin made an impressive re-debut by winning all of the first four matches. But after that series of victories Poli unluckily gained only one victory in the following six games. Although Poli finished second at the end of the 2010–11 Liga I season and was supposed to play in the 2011–12 UEFA Champions League, it was relegated to the Liga II because of accumulated debt and Dušan Uhrin left Poli on 27 July 2011.
