On 3 April 2019, the entry list for the event was released, featuring 19 cars in total. There were 11 cars in the Daytona Prototype International class, and eight entries in GT Le Mans (GTLM). The Le Mans Prototype (LMP2) and GT Daytona (GTD) classes would not be participating in the event. There were few changes to the full-season lineups in either class. Kyle Kaiser, who joined the #50 Juncos Racing Cadillac DPi-V.R for the 24 Hours of Daytona, returned to the car alongside full-season driver Will Owen on a one-race deal. The Thursday before the race, it was announced one of Ford Chip Ganassi Racing's full-season drivers, Joey Hand, would be unable to compete due to suffering symptoms of the flu. His place would be taken by one of their endurance-event drivers, Sébastien Bourdais, who would also be competing in the IndyCar event.
