Shields made his Major League debut against the Baltimore Orioles on May 31, 2006. He surrendered five runs over five innings as he earned a no-decision. On June 5, Shields picked up his first big league win against the Los Angeles Angels of Anaheim, striking out six over six innings of work. On June 21, 2006, Shields became the first Devil Rays pitcher to start his career with 4 straight wins.
