Michigan lost to Ohio State 56–27. Michigan opened the scoring in the first quarter on a 22-yard touchdown run from Giles Jackson, after which Quinn Nordin's extra point missed. Ohio State scored 14 points on a five-yard touchdown run from J. K. Dobbins and a 57-yard touchdown pass from Justin Fields to Chris Olave. Michigan responded with a 25-yard touchdown pass from Shea Patterson to Donovan Peoples-Jones, reducing the Buckeyes' lead to one. Ohio State added 14 points in the second quarter on two touchdown runs from Dobbins, from six-yards, and five-yards, respectively. Michigan scored on a 23-yard field goal by Nordin, which made the score 28–16 in favor of Ohio State at half-time. Ohio State added 14 more points in the third quarter on two touchdown passes from Fields, a six-yard touchdown pass to K. J. Hill and a 30-yard touchdown pass to Garrett Wilson. Michigan scored on a 45-yard field goal by Nordin. In the fourth quarter, Michigan scored on a two-yard touchdown run from Hassan Haskins, followed by a two-point conversion run from Haskins. Ohio State again added 14 points on a 16-yard touchdown pass from Fields to Austin Mack, and a 33-yard touchdown run from Dobbins.
