He was the second son of Sisto Nuzzi, a landowner from Penna in Teverina, and his wife Faustina Salini, sister of the still-life painter Tommaso Salini.Giuseppe Bartocci, "Della patria del pittore Mario Nuzzi", in Atti e memorie della Deputazione di storia patria per le Marche, 1961.Laura Bartoni "Le vie degli artisti: residenze e botteghe nella Roma barocca dai registri di Sant'Andrea della Fratte (1650-1699)", Nuova cultura, Roma, 2013 In 1618, his father took the family back to Penna, where they engaged in floriculture and Mario amused himself by painting the flowers.
