PBT2 showed signs of improving some aspects of cognitive function in the study. The 250 mg dose of PBT2, administered once daily, showed better and statistically significant efficacy over the 12-week treatment period compared to placebo for the Main Composite Cognition Score (p=0.020), Exploratory composite cognition z-score (p=0.016), Executive Function composite Z score (p=0.005) and TMT Part B (p<0.001), a cognitive assessment tool. At 26 weeks, TMT Part B was statistically significantly improved (p=0.042) and the Executive Function composite z score trending to improvement. In patients with early HD (Total Functional Capacity 11-13), the Executive Function composite z score was statistically significantly improved (p=0.038).
