The elections were the first under Mississippi's new congressional map after redistricting completed by the state government. All four races were considered uncompetitive in the general election and turnout from Mississippians was the lowest out of the entire United States, measuring in at 31.5%. Republican Representatives Michael Guest and Steven Palazzo faced competitive primaries, where both went to runoffs; Palazzo was ultimately ousted by Mike Ezell in the runoff, mainly in part to an investigation into Palazzo's supposed misuse of campaign funds. Republican Representative Trent Kelly was the sole representative of the Mississippi delegation to receive a Trump endorsement and faced no serious challenge. The partisan composition of the delegation remained the same after the election.
