A church at the site was apparently erected in the 14th century by the Donesmondi family. Prior to becoming a parish church in the 17th century, it served as chapel for the town Leper hospital. The present facade derives from the reconstruction in 1836 in a neoclassical-style by the architect Giovanni Battista Vergani. During the second world war, the church was heavily damaged by bombardments of the nearby Ponte dei Mulini.
