The mosque is located on Ahl al-Bayt street, where numerous mausoleums commemorating well known Islamic figures exist along the way. Al-Sayeda Nafeesah Mosque is the second destination of the street after Imam Ali Zayn al-Abideen's mausoleum. The street begins with Imam Zayn al-Abideen's maouselum and ends with Al-Sayeda Zaynab Mosque which commemorates Sayyida Zaynab, passing mausoleums of Sayyida Nafisa, Sayyida Sakinah bint Husayn, Sayyida Ruqqiyah bint Ali bin Abu Taleb, Sayyid Muhammad ibn Jafar al-Sadiq, and Sayyida 'Atikah, aunt of Muhammad.
