On March 19, 2021, Drake signed a two-year, $14.5 million contract with the Las Vegas Raiders. He was placed on injured reserve on December 8 with a broken right ankle he suffered against the Washington Football Team in Week 13. Drake finished the 2021 season with 63 carries for 254 rushing yards and two rushing touchdowns to go along with 30 receptions for 291 receiving yards and one receiving touchdown.
