Goldenseal may be commercially cultivated through agroforestry in natural settings mirroring the plant's ecological environment, or on farms with artificial shade canopies. Another propagation method of goldenseal utilizes a controlled environment such as a greenhouse growing lab where the plant's environmental needs such as light, water and temperature are artificially simulated. Crop selection and biotechnology experimentation may be employed to increase yield and pharmacological potency.Canter, P.H., Thomas, H. and Ernst, E., 2005. Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. TRENDS in Biotechnology, 23(4), pp.180–185. Controlled environments can greatly reduce the amount of time required to grow goldenseal to its desired harvestable state. While forest-cultivated plants double in mass every three to five years, plants can double in mass every 15 weeks in growth chambers and triple in growth when in a course soil medium.Adelberg, J., Salido, A., Kelly, R.M. and Beavers, R., 2016. Rapid Growth of High Quality Goldenseal Plants in Controlled Environment Growth Chambers. In Medicinal and Aromatic Crops: Production, Phytochemistry, and Utilization(pp. 65–74). American Chemical Society. Subculturing can take place every 30 days to mass-propagate the plant.Bedir, E., Lata, H., Schaneberg, B., Khan, I.A. and Moraes, R.M., 2003. Micropropagation of Hydrastis canadensis: Goldenseal a North American endangered species. Planta medica, 69(01), pp.86–88.
