On December 18, 2018, C.J Mosley was named to his 4th Pro Bowl of his career. On December 30, 2018, Mosley made 4.5 combined tackles (three solo) and a game-winning interception during a 26–24 victory against the Cleveland Browns in Week 17. Mosley intercepted a pass by Browns' quarterback Baker Mayfield intended for running back, Duke Johnson at 1:06 of the fourth quarter, sealing the victory. The victory resulted in the Ravens clinching the AFC North division against the Pittsburgh Steelers and a playoff spot with a 10–6 record. He finished the season as the Ravens leading tackler with 105 combined tackles, along with half a sack, five passes defensed, and an interception.
