The Gamma saw fairly limited civilian service as mail planes with Trans World Airlines but had an illustrious career as a flying laboratory and record-breaking aircraft. The US military found the design sufficiently interesting to encourage Northrop to develop it into what eventually became the Northrop A-17 light attack aircraft. Military versions of the Gamma saw combat with Chinese and Spanish Republican air forces.Smith 1986 Twenty Five Gamma 2Es were assembled in China from components provided by Northrop; these were deployed in various attack missions during the early stages of the Second Sino-Japanese War, particular against Imperial Japanese naval assets.Eden and Moeng 2002, pp. 74–77. In the morning of 11 November 1937, three Chinese Air Force Northrop 2ECs of the 2nd BG, 14th Squadron led by Capt. Yu attacked the IJN fleet aircraft carrier Kaga off the Ma'anshan Islands; the bombs fell wide into Kaga's wake, and the Chinese Gammas were pursued and intercepted by three A5Ms of Kaga's combat air patrol led by flight leader Jirō Chōno, shooting down two (Gammas no. 1405 of Sung I-Ching and Li Xi-Yong, and no. 1402 of Peng Te-Ming and Li Huan-Chieh) while Yu managed to escape into the clouds and return his damaged Gamma to base.
