Prudhomme was born in Frierson, Louisiana. He started his professional baseball career in 1926, with the New England League's Lawrence Merry Macks. That season, he went 19–11 with a 4.79 earned run average and led the league in wins and innings pitched."1926 New England League Pitching Leaders". baseball-reference.com. Retrieved 2010-12-03. Prudhomme then played in the International League for a few seasons."Augie Prudhomme Minor League Statistics & History". baseball-reference.com. Retrieved 2010-12-03. In 1928, he went 19–15 with a 3.02 ERA, and this earned him a spot on the Detroit Tigers' roster.
