Highway 169 begins at Sulphur Springs in southwestern Ashley County just over from the Louisiana state line. The route runs northeast to Crossett, passing through an industrial section of town. Continuing north, the route intersects and overlaps US 82 at a brief officially designated exception heading west. At Hancock Road, Highway 169 turns north and runs along the west side of a large Georgia-Pacific paper mill. State maintenance ends, with the roadway continuing north at Hancock Road.
