SR 24 begins at an intersection with US 80/SR 26 (East Northside Drive) in Statesboro, within Bulloch County. The highway travels to the east-northeast on East Main Street and intersects US 301 Byp./SR 73 Byp. (Veterans Memorial Parkway), a bypass around the southern and eastern parts of the city. SR 24 continues to the east-northeast, leaves town, and crosses over the Ogeechee River into Screven County. In Oliver, it intersects SR 17 (Scarsboro Highway). Then, in Newington, it intersects SR 21. In the main part of town, it meets SR 21 Bus., the former routing of SR 21. The highway curves to the northwest and travels through rural areas of the county and has a brief concurrency with US 301/SR 73 (Burton's Ferry Highway) north-northeast of Sylvania. After traveling through Hiltonia, it enters Burke County. In Sardis, it intersects SR 23 (Charles Perry Avenue). The highway continues to the northwest toward Waynesboro. Just before entering town, it intersects US 25 Byp./SR 121 Byp., a bypass around most of the eastern part of town. Approximately later, it enters the city limits of town and intersects US 25/SR 121. The three highways travel concurrently into the main part of town. There, they intersect SR 56/SR 80 (6th Street). At this intersection, SR 24 turns left and begins the westerly part of its routing.
