In a rematch of 2018, Poliquin ran in the 2022 election to represent Maine's 2nd District against Democrat Jared Golden. In the Republican primary, he defeated Liz Caruso, a wilderness guide and local government leader from the village of Caratunk, who raised $37,000 to Poliquin’s $2.2 million. He won the Republican primary with 60% of the vote over Caruso. Some political analysts thought Poliquin could win the general election, but he consistently trailed in the polls and lost to Golden, 53%–47%, after the ranked-choice tabulation.
