"Wildfire" was directed by Ernest Dickerson and written by Glen Mazzara. Actor Noah Emmerich made a guest appearance on the show, portraying the character of Edwin Jenner, one of the few remaining medical personnel dedicated to eradicating the virus. Emmerich's appearance was formally announced in November 2010. Creator Frank Darabont foreshadowed the development of the episode the same month, alongside predecessor "Vatos" and the first season finale, "TS-19". "Before it's all said and done, the opinions and actions of the group are divided." Producer Gale Anne Hurd added, "Stakes are higher, dissension develops, rivalries intensify."
