In time, Jaggard developed one of the largest print shops of his generation; he was eventually assisted by his son Isaac (died 1627), who succeeded to his father's business in 1623. In their era, most members of the stationers guild were either printers or booksellers; both were businessmen with their own establishments, journeymen and apprentices,In March 1610 William Jaggard took on an apprentice named John Shakespeare, son of Warwick butcher Thomas Shakespeare, and no relation to the poet. though in anachronistic modern terms printers could be regarded as blue-collar while the booksellers were white-collar retailers. Most commercial publishing was done by booksellers, who chose their books and commissioned printers to print them. The distinction, while generally valid, was not absolute; some successful printers, like Richard Field, published a significant minority of the works they printed. The Jaggards too did a significant amount of publishing as well as printing; in the most obvious case, they not only printed the First Folio but were partners in its publication with bookseller Edward Blount. Printers who published often needed a retail outlet for their wares; Jaggard's books were frequently sold by Matthew Lownes at his shop in St. Paul's Churchyard, the centre of the book trade in London.
