In the opener of a three-game home series, the Red Sox defeated the Blue Jays, 2–1, despite being outhit, 8–3. Starter Nathan Eovaldi went innings and had a no decision. Hansel Robles got the win in relief, and Garrett Whitlock earned a save. Prior to the second game of the series, the team honored former player and longtime broadcaster Jerry Remy, who died in October 2021. Boston took an early 1–0 lead in the game, but Toronto scored five runs in the second inning, en route to a 6–1 win. Starter Nick Pivetta took the loss, falling to 0–3 on the season. In the third game of the series, the Red Sox rallied for two runs in the ninth inning, but fell to the Blue Jays, 3–2. Starter Tanner Houck took the loss. Xander Bogaerts had three hits and an RBI.
