The earliest settlements in Isuwa show cultural contacts with Tell Brak to the south, though not being the same culture. Agriculture began early due to favorable climatic conditions. Isuwa was at the outer fringe of the early Mesopotamian Uruk period culture. The people of Isuwa were also skilled in metallurgy and they reached the Bronze Age in the fourth millennium BC. Copper was first mixed with arsenic, later with tin. The Early Bronze Age culture was linked with the Caucasus in the northeast. In the Hittite period the culture of Isuwa shows great parallels to the Central Anatolian and Hurrian cultures to the south. The monumental architecture was of Hittite influence. The Neo-Hittite state show influences both from Phrygia, Assyria and the eastern kingdom of Urartu. After the Scythian people migrated to the region, some Scythian burials appear in the area.
