While no official music video was shot, a compilation made up of scenes from Desperately Seeking Susan was created to accompany the release, and received heavy rotation on MTV. Madonna has performed "Into the Groove" on six of her concert tours, the last being 2015–2016's Rebel Heart Tour. It has been covered and sampled by many artists, notably Australian singer Dannii Minogue, who released a mashup of "Into The Groove" and her 2003 single "Don't Wanna Lose This Feeling".
