2017 saw the Panthers get off to a rough start, falling to eventual NCAA Tournament teams North Carolina, Elon, and James Madison. However, the Panthers regained their footing by winning their last six nonconference games. Led by five players who scored 38+ goals, the Panthers swept through the Big South regular season and captured the conference tournament championship, outscoring every opponent by 7+ goals. The program garnered its first NCAA tournament win (and the first in High Point Panthers history) by defeating Towson, 21-15. The team then faced top-seeded Maryland, where they lost 6-21, ending a team record 16-game win streak.
