RE5 project chief Shigeyasu Kamiya stated that Suzuki had considered a rotary-powered motorcycle in the mid-1960s. Research and development continued till the end of that decade, leading to the signing of a technical licence with NSU in November 1970, Suzuki being the 20th firm to do so. As a pioneer of rotary development, Suzuki engineers designed and produced numerous special machines for the rotary production process. Of these, ten were particularly notable and included the machine to cut the trochoid block. Suzuki holds twenty patents in plating, as considerable research went into the composite electro-chemical materials (CEM) used to plate the rotor housing. Prototypes testing took two years. The bikes were launched in 1974. Suzuki enlisted astronaut Edgar Mitchell, to introduce and endorse the bike. A number of motorcycle publications were given a lavish week-long opportunity for test riding. This RE5's warranty was unusually comprehensive, with a full engine replacement for any engine problem within the first 12 months or .
