Season two also featured many guest appearances. Jon Glaser voiced Ogg in "Super Computer" and "The Last One" and Jerry in "The Broodwich", Brooks Braselman voiced Travis of the Cosmos in "Super Spore" and "The Last One", Ned Hastings, Seth MacFarlane as Wayne 'The Main Brain' McClane in "Super Triva", Zakk Wylde voiced the co-writer to Master Shake's song in "Spirit Journey Formation Anniversary", Tom Scharpling voiced Willie Nelson in "The Shaving", H. Jon Benjamin voiced Mr. Sticks in the Broodwich and reprised his role as Mothmonsterman in "The Last One", Isaac Hayes III was the voice in "The Broodwich" and "The Last One", in "The Cubing" and "The Last One" Jon Schnepp voiced the first Wisdom Cube and Brian Posehn voiced the second Wisdom Cube, Patton Oswalt voiced D.P. and Skeeter in "Frat Aliens" and "The Last One", Barry Mills voiced the turkey in "The Dressing", Ned Hastings and Jay Edwards made voice cameos of themselves in "The", and Scott Hilley voiced George Washington made out of money in "The Cloning". In "The Last One". Several guest stars from season one returned and reprised their roles: David Cross voiced Happy Time Harry, Todd Barry voice Romulux, Todd Field voiced Ol' Drippy, MC Chris voiced MC Pee Pants (who eventually came back in the form of a cow named Sir Loin, and an old man as Little Brittle), and Matt Harrigan voiced Major Shake.
