West Nanticoke is located at , along U.S. Route 11, on the north bank of the Susquehanna River. It is across the river from the city of Nanticoke, to which it is connected by the Lower Broadway Street Bridge. Pennsylvania Route 29 joins U.S. Route 11 in the center of West Nanticoke. To the north, Route 29 leads to Silkworth and Pikes Creek. Just east of West Nanticoke, Route 29 becomes the South Cross Valley Expressway, crossing the Susquehanna River and leading to Interstate 81 south of Wilkes-Barre. U.S. Route 11 heads northeast to Plymouth and Kingston and southwest to Shickshinny and Berwick.
