Pirivom Santhippom, which saw her collaborating with Karu Pazhaniappan again, was her first film in 2008. Co-starring Cheran, the film opened to critical acclaim and emerged a sleeper hit, while fetching Sneha plaudits and several accolades. A review from Sify noted that she was "superb as Sala, a woman torn by the dualities of her existence", labelling it as her "career best performance". She won her second Tamil Nadu State Film Award for Best Actress, besides the Vijay Award for Best Actress and a nomination for the Filmfare Award for Best Actress Award. She tried highly glamorous roles with Pandi and Inba, both turning out to be average grossers. She paired with Silambarasan in Silambattam, which gave her another commercial success. Her Telugu films Nee Sukhame Ne Korukunna and Pandurangadu turned out to be average grossers while Adi Vishnu was unsuccessful.
