Rebuttal to the objection: 1) Stereo selective transport of the anesthetic was never considered. Anesthetics are hydrophobic and transported bound to proteins in the blood. Any stereo selective binding to the transport protein would change the concentration at the site of action. Furthermore a protein sink in the membrane could bind one of the isomers slightly better and reduce the effective concentration the membrane experiences. All stereo isomers are effective anesthetics, they only shifted the sensitivity, suggesting selective transport and selective protein sinks need to be considered. 2) Lipids are chiral, the same as proteins. And like proteins, lipids have ordered and disordered regions. The field failed to investigate the chirality of ordered lipids due to a lack of knowledge of their existence.
