As a continuity reboot, the 2021 series has notable differences to the original 1991 series; some of which was done to accommodate the 30-year difference between the two. The most notable change came with the character Betty DeVille. Originally portrayed as a strong feminist woman with a "weak" husband in Howard, Betty is now portrayed as a lesbian, and Howard is absent. Betty's voice actress, Natalie Morales, stated about the change that "anyone who watched the original show may have had an inkling Betty was a member of the alphabet mafia."
