On 2 February 2013, after Zeman was relieved from his duties, Andreazzoli was appointed manager until the end of the 2012–13 season. His first win came in a 1–0 home win over Serie A leaders Juventus. On 8 April 2013, his side drew 1–1 with Lazio in his first Derby della Capitale as Roma manager. On 17 April 2013, he led Roma to the 2012–13 Coppa Italia final with a 2–3 win over Internazionale at the San Siro. On 26 May 2013, he led Roma on the most important match of his career in the competition final against intercity rivals Lazio, which Roma lost 0–1.
