His first wife was the daughter of Rabbi Yitzchok of Volozhin, the son of Rabbi Chaim Volozhin. His second wife was his niece, a daughter of Rabbi Yechiel Michel Epstein, the author of the Aruch haShulchan. A son from his first marriage, Chaim Berlin, became the rabbi of Moscow, a daughter married Rabbi Refael Shapiro, and his son from his second marriage was Rabbi Meir Berlin (later Bar-Ilan).
