Santaquin lies southeast of Utah Lake in southern Utah County, with a small portion extending south into Juab County. It is bordered to the northwest by Genola and to the north by unincorporated Spring Lake. Interstate 15 passes through the city, with access from Exits 242 and 244. I-15 leads north to Provo and south to Nephi. U.S. Route 6 passes through Santaquin as Main Street and leads west to Silver City. Utah State Route 198 leads north from I-15 to Payson.
