After a junior career in Portugal, a country which citinzeship Murilo also holds, Murilo moved back to Brazil to play in the Brazilian Serie D, and joined the ranks of Rio Ave F.C.. After his short tenure in Brazil, he returned to Europe to join Spanish fifth division CD Cultural Areas in 2016. From there, he joined Ourense CF, where he played for four years. in 2020, Murilo was spotted by scouts and was offered a contract by Veikkausliiga side SJK Seinäjoki. During the 2020 Veikkausliiga season, he appeared in ten matches. During the following 2021 season, Murilo broke through, appearing in 25 of 27 Veikkausliiga matches. Murilo recorded eight assists and one goal in all competitions as SJK placed third.https://www.hjk.fi/pelaaja/murilo-henrique-de-araujo-santos/ On 5 November 2021, Murilo signed a two-year contract with HJK. During the 2022 season , Murilo recorded 19 matches and 5 assists in the league. He also scored a vital free-kick goal in the first round of UEFA Champions League 2022-23 qualifying against FK Rīgas Futbola Skola,https://www.uefa.com/uefachampionsleague/match/2034968--rfs-vs-hjk/ which tied the leg, which HJK went on to win on penalties, one of which Murilo scored. HJK ended up qualifying for the Europa League, however, Murilo only played in the first match, against Real Betis, coming on as a sub in the 76th minute.https://www.uefa.com/uefaeuropaleague/match/2035978--hjk-vs-betis/lineups/ He returned to SJK ahead of the 2023 season.
