Seeded seventh at the Rio Open, Alcaraz won his first ATP 500 title defeating Diego Schwartzman in the final. As a result, he made his debut into the top 20 in the singles rankings on 21 February 2022. In Indian Wells, Alcaraz reached his first Masters 1000 quarterfinal and semifinal, defeating the defending champion Cameron Norrie before losing to Rafael Nadal.
