Ohio State's first road game of the season took them to south Florida for a rematch against the Miami Hurricanes who they faced in the 2010 season, as well as the 2003 Fiesta Bowl, beating them both times. The game did not start well for the Buckeyes, with a bad opening offensive drive, giving Miami good field position. The Hurricanes quickly drove down the field 63 yards and scored their first points of the game on a Jacory Harris touchdown pass. Later in the quarter, Miami again drove down the field for another Harris touchdown pass, giving the Hurricanes a 14–0 lead at the end of the first quarter. The second quarter saw the momentum swing in favor of Ohio State, with two drives heading deep into Miami territory, however, once in the red zone, the Buckeyes were unable to capitalize and had to settle for two short range field goals by Drew Basil, bringing them closer in the games and giving Miami only a 14–6 lead. However a field goal at the end of the first half gave Miami a two-possession lead heading into halftime. The second half of the game saw little offense, with both the Buckeyes' defense dominating the Hurricanes and keeping them out of Ohio State territory, as well at the Buckeye offense continuing to struggle to get any kind of rhythm. Miami was able to score a touchdown with 0:33 remaining in the game, giving them a 24–6 lead—the final score of the game. The game was the first non-conference loss since the September 12, 2009 loss against the University of Southern California.
