Khan’s initial work in emergency preparedness started in 1999 when he helped establish CDC’s bioterrorism program, which upgraded local, state, and national public health systems to detect and rapidly respond to bioterrorism. As deputy director of the bioterrorism program, Khan created the Critical Agent list, which has remained the basis for all biological terrorism preparedness. Dr. Khan also published the first national public health preparedness plan, initiated syndrome based surveillance, and designed key focus areas to improve local and State capacities to respond to emergencies. Khan used these preparedness efforts during the first anthrax attack in 2001, during which he directed the CDC operational response in Washington, D.C.
