Keefe started his professional baseball career with the Sacramento Senators in 1903, the first year of the Pacific Coast League (PCL). The following year, the Sacramento franchise moved to Tacoma, Washington, and Keefe spent two seasons with the Tacoma Tigers. In 1904, he had 438.2 innings pitched, a win–loss record of 34–15, and a 2.40 earned run average (ERA). He had the second-most wins in the PCL and helped the Tigers win the league championship. In 1905, Keefe had 468.2 innings pitched and went 30–22 with a 1.61 ERA. He had the second-most wins in the PCL again."Bobby Keefe Independent & Minor Leagues Statistics & History". baseball-reference.com. Retrieved October 28, 2021.
