Southworth set new team records for games managed (981), wins (620) and World Series championships (two). His Cardinals teams won 105 or more games each year from 1942 to 1944, winning the NL pennants in each of those three seasons. His .642 winning percentage is second-highest in team history, and the highest since the Cardinals joined the National League. Southworth was also awarded the Sporting News Manager of the Year Award in 1941 and 1942. Starting in 1953 with the Gussie Busch/Anheuser-Busch era, thirteen managers captained the club in 43 seasons. After Southworth, Eddie Dyer, Eddie Stanky, Fred Hutchinson and Johnny Keane also each took home a Sporting News Manager of the Year award. Keane's 1964 team that year's World Series. Hall of Famer Red Schoendienst took over from 1965 to 1977 and won one World Series and two NL pennants. Schoendienst then broke Southworth's team records for games (1,999 total) and wins (1,041). He also held records of 14 seasons managed and 955 losses.
