The cannon was put to use both on land and at sea. It was fitted to numerous Royal Navy warships of different sizes such as , , , and the Conqueror-class ships of the line. Several of these ships saw action during the Crimean War where the 68-pounder was used extensively during the Siege of Sevastopol.Winton (2001), p. 112 Along with 32-pounders and Lancaster guns they were taken from their ship mountings and dragged up to siege batteries by the Naval Brigade, from where they regularly bombarded Russian positions for the next year. The cannon was also fitted in large numbers to the Aetna-class ironclad floating batteries, although these had little impact on the war.
