Dameon Clarke voices Handsome Jack. Clarke was asked to audition "by chance" after he finished recording session for Dragon Ball Kai in the same studio Okatron5000 and did as a favor to Chris Sabat. Clarke was initially intended to voice secondary characters in the game, but was asked to try for the role of Jack. Burch has said Clarke grasped the character "immediately", and soon began ad-libbing and improving lines.
