Coming into this game, the Falcons were (once again) the number one rushing team in the NFL. Against the hapless Arizona Cardinals, QB Mike Vick and RB Jerious Norwood both ran for over 100 yards each, making the Falcons the only NFL team in history to have a quarterback and running back run for 100+ yards in a game twice in a franchise's history. (Vick and RB Warrick Dunn both surpassed the 100-yard rushing mark in Week 2). Jerious Norwood also set a new franchise record for the longest run in team history with a 78-yard touchdown. Atlanta's victory was led by their defense and they ended Kurt Warner’s undefeated streak at the Georgia Dome. Warner was promptly benched because of his sub-par play; Patrick Kerney’s two sacks didn't help his cause either. Matt Leinart played in his first NFL game as a rookie. Even with Arizona's adjustments, the Falcons managed to rebound and held on to win 32–10. Atlanta entered its bye week at 3–1.
