Francesco Barbaro was the son of Candiano Barbaro, uncle of Ermolao Barbaro, grandfather of the younger Ermolao Barbaro, and great-great grandfather of Marcantonio Barbaro and Daniele Barbaro. Francesco's father died in 1391 and Francesco was raised by his older brother Zaccaria. In 1419, Franceso married Maria Loredan, daughter of Procurator Pietro Loredan. Francesco and Maria had five daughters and one son, Zaccaria, who was born in 1422.Venice: A Documentary History, 1450-1630, Brian Pullan, 2001, University of Toronto Press, pg.201
