Greenup is located southeast of the center of Cumberland County at (39.247273, -88.162131). The Embarras River is a tributary of the Wabash River which runs past the northwest corner of the village. U.S. Route 40 runs through the village to the south of its center, while Interstate 70 runs through the northern corner of the village with access from Exit 119 (Illinois Route 130). Effingham is to the west, while Terre Haute, Indiana, is to the east.
