Jana Reddy was born in Anumula, a village near historic Nagarjuna Sagar in the Nalgonda district. His political career started by joining the Telugu Desam Party founded by Nandamuri Taraka Rama Rao, and was first elected to the State Legislature from the Chalakurthi constituency of the Nalgonda district in 1983. He was re-elected for seven terms to the Assembly from the Chalakurthi constituency, and went on to hold portfolios such as Agriculture, Co-operative, Marketing, Forest, Animal Husbandry, Fisheries, Weights & Measures, C.A.D., Transport, Roads & Buildings, Housing Panchayath Raj, Rural water scheme and Sanitation in the government of Andhra Pradesh. He is the longest serving cabinet minister in government of Telangana breaking the record of Sri Kasu Bramanadha Reddy former chief minister of A.P.
