In an email responding to a constituent Humphrey said "I understand transgender people have mental illness". This view is not supported by the World Health Organization or the American Psychiatric Association. In an interview published after the incident on April 15, 2021, Humphrey doubled down by saying "I want to tell your audience there is no transgender. There is male and there is female. And transgender would be a mental health issue... So those people that say I'm bigoted, I will say you're insane and you're doing the people wrong by doing that." Freedom Oklahoma, an LGBT advocacy group, denounced Humphrey's comments calling them "a long-debunked myth".
