Evidence synthesis can be applied to important and, notably, both relatively urgent and certain global challenges: "climate change, energy transitions, biodiversity loss, antimicrobial resistance, poverty eradication and so on". It was suggested that a better system would keep summaries of research evidence up to date via living systematic reviews – e.g. as living documents. While the number of scientific papers and data (or information and online knowledge) has risen substantially, the number of published academic systematic reviews has risen from "around 6,000 in 2011 to more than 45,000 in 2021". An evidence-based approach is important for progress in science, policy, medical and other practices. For example, meta-analyses can quantify what is known and identify what is not yet known and place "truly innovative and highly interdisciplinary ideas" into the context of established knowledge which may enhance their impact.
