State Route 106 was originally created in 1964, and ran from State Route 38 in Redlands to State Route 18 in Running Springs. Prior to 1964, the highway was a part of Legislative Route 190, which ran from US 66 to State Route 38. After 1964, the route was split in half. The western portion became State Route 30. The eastern portion was combined with Legislative Route 207, and became State Route 106. A year later, its southern terminus was moved to Interstate 10. In 1972, State Route 106 was decommissioned. The northern portion between State Route 30 and State Route 18 was renumbered to State Route 330. The southern portion was added to State Route 30, extending it to Interstate 10. This also reconnected both halves of the original Legislative Route 190.
