In 1155, Hettenleidelheim had its first documentary mention and was originally made up of two centres: Hitenheim (later Hettenheim) and Luttelheim (later Leidelheim). Both fell under the Ramsen Monastery's lordship in the Middle Ages, passing to the Bishopric of Worms in 1485 after the monastery's dissolution. Municipal union under a common village court goes back to 1556. In the time of the Reformation, Hettenheim and Leidelheim, along with the outlying Protestant parishes of Eisenberg and Wattenheim, became Lutheran. However, already by about 1634, when the Catholic party got the upper hand in the Thirty Years' War, the two municipalities were first reassigned to the Catholic parish of Neuleiningen, and then in 1705 and 1707, the united municipality was raised to a Catholic parish in its own right. From the mid 19th century, and increasingly as of about 1870, the quarrying of the local highly fireproof clays grew into the municipality's main branch of industry, expanding to industrialized recovery in 1901. After the Second World War, though, this industry was disrupted. Until 1969, the municipality belonged to the now abolished district of Frankenthal. In 2005, Hettenleidelheim celebrated its 850-year jubilee.
