Pérez debuted for Boyacá Chicó in 2006 at the age of 17, and became a starter ahead more experienced strikers. El Real Zaragoza ficha a Marco Pérez Murillo He played the 2009–10 Argentine Primera División season on loan with Gimnasia y Esgrima La Plata, and helped the team avoid relegation from the first division. On 14 July 2010, Pérez signed a two-year loan deal with La Liga club Real Zaragoza.Marco Pérez presentado However, in July 2011 the Colombian forward left Zaragoza after poor performances, and returned to Argentina, joining Independiente.
