On 9 January 1816, he succeeded his father, Duke Frederick William, as the Prince of Nassau-Weilburg and joint Duke of Nassau with his cousin, Frederick Augustus, of the Nassau-Usingen branch of his family. When his cousin and co-Duke died on 24 March 1816, Wilhelm inherited the Usingen territories and became sole ruler of the Duchy of Nassau. He kept the title of Duke of Nassau for the rest of his reign.
