Acremostrictin can be isolated from certain strains of A. strictum and is characterized as a highly oxygenated, tricyclic lactone metabolite. This compound exhibits weak antibacterial properties against the bacterium Micrococcus luteus, Salmonella typhimurium and Proteus vulgaris. However, it had no effect on Bacillus subtilis, Staphylococcus aureus and Escherichia coli. Acremostrictin has been shown to have concentration-dependent antioxidant activity, which conferred protection against oxidative stress induced cell death. Acremostrictin was shown to inhibit H2O2-induced death of human keratinocyte HaCaT cells. When extracted and isolated by filtration, acremostrictin presents as a colorless crystal solid.
