He got direct entry into a Grand Slam tournament for the first time in his career at the 2010 French Open. Przysiężny lost in straights sets in the first round to eventual quarterfinalist Mikhail Youzhny. He then entered the Wimbledon main draw for the first time, where he was met 17th seed Ivan Ljubičić. Przysiężny scored the biggest win of his career, defeating the Croatian in straight sets, subsequently losing in the second round to eventual quarterfinalist Yen-Hsun Lu. At the US Open, he faced 21st seed Albert Montañés, losing in five sets. Michał served for the match at 6–5 in the fourth set, squandering two match points.
