5th enslaving voyage (1805–1806): war with France had resumed in May 1803. Captain Timothy Boardman acquired a letter of marque on 29 April 1805. He sailed from Liverpool on 5 June. Otter gathered her captives at Gabon and the Cameroons, and delivered them to Saint Thomas on 6 March 1806. She landed some 280 captives. She then sailed for Liverpool on 6 April and arrived there on 7 July. She had left with 40 crewmen and she suffered five crew deaths on the voyage.
