The church structure was erected by Father Geronimo de Belen in the early 1600s after the establishment of the Dominican mission in Abucay on June 10, 1588. On June 23, 1647, the Dutch Naval Forces who invaded Manila and its neighboring provinces massacred hundreds of Kapampangans and Spanish officials and priests in the church complex, while others were taken to Batavia, a former Dutch colony. The current church was significantly damaged by an earthquake on September 16, 1852. Major changes were made into the structure before the Second World War, as stated in a medallion placed on top of the church's main portal with the inscription "Mayo de 1925 ".
