In around 1750, she attracted the attention of Louis XV, with whom she had an affair at about the same time as the king's affair to Marie Geneviève Radix de Sainte-Foy. The relationship was not an official one, as Madame de Pompadour remained the king's official mistress. Not long after this, Louis XV had Marie-Louise O'Murphy installed at the Parc-aux-Cerfs.
