Vedder-Wubben became politically active for the Christian Democratic Appeal in The Hague. She subsequently became member of the Senate for the party, serving from 10 June 2003 until 7 June 2011. In 2010 a government plan to cut the Algemene Ouderdomswet partner allowance was likely to fail in the vote in the Senate, with Vedder-Wubben devising a new plan from which the government went ahead.
