Samuel Moore introduced Vyner to the goldsmithing trade. Vyner soon became a member of the Worshipful Company of Goldsmiths and later became its prime warden. In 1622, Vyner purchased a mansion in what was then the village of Hackney near London. On 8 July 1624, James I appointed Vyner to the office of comptroller of the mint. Under the regime of Oliver Cromwell, Vyner supplied large quantities of gold bullion to and created coinage for both the English government and the East India Company. In 1656, he and a partner purchased a large quantity of Spanish bullion to be converted into coins.
