On February 16, MSU traveled to face Purdue in West Lafayette. MSU kept the game close throughout, even taking the lead at points in the second half. Aaron Henry led the Spartans with 15 points and Maddy Sissoko played well in the first half, scoring five points in six minutes. Julius Marble added 10 points in 19 minutes. Sissoko did not play in the second half as the Spartans went mostly with Thomas Kithier and Marble. As a result, the Boilermakers were able to pull away and won by 11, 76–65. MSU shot the ball pretty well, making 44% of their field goals including 43% from three. Purdue struggled from three, making only three, but dominated inside as Trevion Williams scored 28 points to lead all scorers while Purdue's other big man, Zach Edey added 10 points in just eight minutes of play. The loss moved MSU to 10–9, 4–9 on the season.
