Because sterigmatocystin (ST) is an intermediate of the aflatoxin biosynthesis pathway and is produced by the BSL-1 organism Aspergillus nidulans, it serves as a model for studying regulation of the aflatoxin biosynthetic gene cluster (BGC). Sterigmatocystin was shown to be produced only in the absence of glucose (carbon catabolite repression) but independent of CreA when glucose is used as sole carbon source. Instead, it was shown to be dependent on a regulator of G0 which transmits the glucose signal to downstream targets.
