On April 6, 2021, Matarazzo participated in an hour-long charity Among Us stream on The Tonight Show's Twitch account with Jimmy Fallon, Questlove, Tariq Trotter, Captain Kirk Douglas, Sykkuno, Valkyrae, Corpse Husband, and his Stranger Things co-star Noah Schnapp, with proceeds going towards Feeding America. In December 2021, he played Dungeons and Dragons with Jack Black and other stars in the Lost Odyssey: Promised Gold livestream event that benefited Extra Life and the Children’s Miracle Network Hospitals.
