The champions, 1. FC Eschborn, were promoted to the 2012–13 Regionalliga Südwest. Viktoria Aschaffenburg exchanged their membership of the Hessischer Fußball-Verband (HFV; Hessian Football Association) for the Bavarian Football Association and were promoted one tier to the newly established Fußball-Regionalliga Bayern. Rot-Weiss Frankfurt and Eintracht Wetzlar were relegated to their respective Verbandsligen. 1. FCA Darmstadt took on the runners-up of the Verbandsligen Nord (TSV Lehnerz), Mitte (FC 1931 Eddersheim) and Süd (Kickers Obertshausen), finished first in the group, and thus secured their place in the 2012–13 Hessenliga along with second-placed FC 1931 Eddersheim.
