Twelve teams competed in the 2021–22 NIFL Premiership, the same twelve teams from the previous season. No relegation took place from the previous season's Premiership, after a majority of second-tier NIFL Championship clubs voted to cancel their 2020–21 season. The second and third tiers had not been granted 'elite' sporting status by the IFA which was required in order to continue playing matches during the COVID-19 pandemic lockdown, with lower division clubs not having played any league fixtures since the 2019–20 season had initially been suspended in March 2020.
