Doss was born in Minneapolis, Minnesota. Doss's parents divorced when she was a child, and she lived with her mother, Kelly Skalicky, who later married her partner, Veronica, who shared parenting responsibilities. Her family first lived in Albuquerque, New Mexico, for two years, and later she spent most of her childhood in Chicago, and then moved to New York City. She graduated from the Professional Children's School in Manhattan. Doss attended New York University's Gallatin School of Individualized Study. In New York, she began performing on off-Broadway stage, and later on regional stage. In 2013, she made her television debut, appearing in an episode of NBC comedy series 30 Rock. She has appeared in series including Person of Interest, Bull and Girls. In 2014, She made her Broadway debut in the comedic play You Can't Take It with You appearing opposite James Earl Jones and Rose Byrne.
