Puligo was trained under Ridolfo Ghirlandaio, the son of Domenico Ghirlandaio, who once trained Michelangelo as an apprentice. Puligo was one of the only two apprentices, the other being Antonio del Ceraiuolo, that continued to work with Ghirlandaio for many years, even after they had finished their apprenticeship. According to Vasari, Puligo and Ceraiuolo had received invitations to work in Span and Hungary, but were not enticed even by the guarantee of money and rejected the offers to remain in their own country, where there was still much to be done.
