In 1999 Spence made his professional breakthrough with victory in the Ericsson Australian Masters. Having opened up with a 9 under par first round, he finished by hitting a 6 iron to two feet for a birdie on the final hole to win by a single stroke over Australia's most successful golfer, playing partner Greg Norman. Following that win Spence received invites to tournaments around the world, on five of the major tours. He managed to record top 5 finishes in events on all of those tours.
