Pennsylvania Route 28 passes through the borough, crossing Redbank Creek into South Bethlehem, then leading southwest to Kittanning on the Allegheny River. To the northeast, PA 28 leads to Brookville and Interstate 80. Pennsylvania Route 66 intersects PA 28 in the center of New Bethlehem and leads north to I-80 and to Clarion, the county seat. PA 66 travels with PA 28 southwest to Kittanning. Pennsylvania Route 861 leads west from New Bethlehem to Rimersburg.
