His paintings were highly prized and collected at the court of Frederik Hendrik in The Hague. There, the art collector and secretary to the prince Constantijn Huygens praised the paintings in poetry and corresponded numerous times with the artist, writing that one could almost smell the flowers.Huygens praise of Seghers' painted flowers (in Latin), In Praestantissimi Pictoris Dan. Segheri Rosas. The Dutch poet Joost van den Vondel also wrote highly of Seghers' paintings. Other collectors included Christina of Sweden, Charles I, Philip IV of Spain, Maria de' Medici, Charles II, who visited the artist in 1649, and Archduke Leopold Wilhelm of Austria, the Italian collector Scipione Borghese and the Antwerp collector and patron of Anthony van Dyck, Cornelis van der Geest.
