Porizkova appeared in Emir Kusturica's 1993 film Arizona Dream, with Johnny Depp and Jerry Lewis, in a minor role as Lewis's young Polish fiancée. She had the main female role in the 1998 film Thursday. Porizkova wrote and directed the 2001 film, Roommates. She also starred in the 2001 thriller film Dark Asylum, alongside Judd Nelson. In 2004, she starred in the romantic comedy Knots. She appeared in an episode of the Starz comedy series Head Case which aired on 24 April 2009. She appeared in a 6th-season episode of Desperate Housewives, "Chromolume No. 7", alongside model Heidi Klum. She appeared on the ABC Family drama-comedy series Jane by Design in an episode which aired on 6 March 2012, and made a guest appearance on The Mysteries of Laura in February 2015.
