Clinical practice (undergraduate medical education during the third and fourth years of medical school), graduate medical education, and research takes place across eight campuses located throughout Michigan Flint, Grand Rapids, Lansing, Midland, Marquette, Southeast Michigan and Traverse City. In 2022, CHM opened a new campus in Detroit, MI with the Henry Ford Hospital main campus. The college previously had a Saginaw campus, but that was transitioned to the Central Michigan University College of Medicine in 2011. The campus in Kalamazoo, was transitioned to Western Michigan University in 2014. Students are assigned to one of the campuses for their third and fourth years, rather than a specific hospital. The campus administration then places students at hospitals within the campus. After submitting a request, clinical students are also able to take a clerkship at a campus other than their assigned campus. Students may fulfill clerkship electives outside of the MSU system only in their fourth year.
