His most notable work as a director is the 2015 adaptation of the book Lamb, which Partridge wrote, starred in and directed. As an actor, he has had recurring roles in the critically acclaimed Netflix series Stranger Things, the Showtime series Billions, and the HBO series Insecure. He is the co-executive producer of Room 104 and has also directed three episodes ("Phoenix", "FOMO", and "Mr. Mulvahill"), written two episodes, and starred in one episode of the series.
