In 2012, following the reconfiguration of the state's legislative districts, Negron was moved into the 32nd District, where he ran for re-election. He was opposed by Ray D'Amiano, a businessman and the Democratic nominee, who raised little money, and was attacked by D'Amiano for the amount of money he was raising. The Palm Beach Post endorsed Negron, praising him as one of the legislature's "most influential Republican leaders" and "one of his party's more thoughtful and moderating voices." They noted, however, "We hope Sen. Negron does modify his position on many issues, from the expansion of Medicaid to the need to tax Internet sales to pay for priorities like public education." Negron ended up defeating D'Amiano by a wide margin, receiving 60% of the vote to D'Amiano's 40%.
