Six months after the events of the Blade II film, Blade having vanquished Nomak and the Reapers, the Blade II video game opens with Blade and Whistler receiving information of a blood exchange taking place between a mafia outfit and a vampire clan in the parking lot of Karkov Towers, a multi-company tower block and possible vampire safe house. Blade arrives just in time to see the exchange, with a suited vampire disappearing into the tower carrying a briefcase and is told by Whistler that the briefcase contains a vial of DNA and must be recovered. After fighting his way into the tower through the underground car park, and passing through the "Exploitika" nightclub, Blade destroys the computer mainframe of a vampire-run company called Nth Phase. Finding the vampire with the briefcase, Blade learns that the DNA is actually that of Damaskinos, former overlord of the Vampire Nation, and a DNA sequencer is currently unraveling the DNA. Blade is able to destroy the machine and then meets Whistler on the roof, giving him a canister of poison, which Blade puts into the ventilation system, killing every vampire in the building.
