Gregorio remained active in film and television during the 1980s and 1990s. Her film credits include Brenda Samuels in True Confessions (1981), Mrs. Sabantino in Five Corners (1987), Pina in City of Hope (1991), Pina in Tarantella (1995), Grandma Rosie Cappadora in The Deep End of the Ocean (1999), and Helen in Maze (2000). On television, she portrayed Helen Hathaway, the mother of Carol Hathaway, on ER between 1996-99. She made guest appearances on The Doctors (1972), The Bob Newhart Show (1974), Medical Center (1974), The Rookies (1975), Harry O (1975), Jigsaw John (1976), Mary Hartman, Mary Hartman (1976), The Rockford Files (1978), Charlie's Angels (1979), Falcon Crest (1984), Doogie Howser, M.D. (1989), Murder, She Wrote (1991), The Practice (1997) and Law & Order: Criminal Intent (2003), and appeared in numerous television movies.
