On 22 October 1494, Duke Gian Galeazzo died in mysterious circumstances: formally for not having followed the treatment prescribed by his personal doctors for an illness that had been dragging on for some time and for the immoderate life he led, but in the opinion of many prominent contemporaries, such as Machiavelli or Guicciardini, the person responsible for this death was his uncle Ludovico, for poisoning; Malaguzzi Valeri strongly disagrees with this opinion, pointing out how Ludovico was really interested in the approval of his nephew, how he often sent him gifts such as dogs, horses and falcons, and how he was kept constantly informed of the care given to him; he also recalls that Gian Galeazzo had begun to manifest the first stomach disorders already at the age of 13 and that in fact he continuously disobeyed the prescriptions of doctors, continuing to pour wine out of measure and to fatigue in continuous hunting trips and in a disordered sexual life..
