The Cube appears in The Avengers: Earth's Mightiest Heroes. First appearing in the episode "Breakout, Part 1", this version is a S.H.I.E.L.D. prison for gamma-powered supervillains and housed the Leader, the Abomination, Absorbing Man, Madman, the U-Foes, the Wrecking Crew, Bi-Beast, Radioactive Man, and Zzzax before a mysterious technological fault allows them to escape. In the two-part episode "Gamma World", the Leader uses the Cube as a staging ground to turn the world into gamma monsters before the Avengers defeat him.
