Beyond the I-76 interchange, the speed limit increases to . The freeway heads southeast, comes to a westbound exit and eastbound entrance with York Street, and crosses the South Platte River into a commercial area in Adams County. I-270 enters the city of Commerce City, running roughly parallel with the nearby Sand Creek and crossing over SH 265 without an exit. Continuing through the city, the route comes to a cloverleaf interchange with Vasquez Boulevard, which carries US 6, US 85, and SH 2. The freeway heads eastward into Denver, where it has an exit at SH 35, a short highway which continues northward along Quebec Street for . Quebec Street provides access for traffic heading to westbound I-70. The route ends shortly thereafter when it merges into I-70.
