Mosadi Seboko was born on 7 June 1950 in Ramotswa, south of Gaborone. Her name Mosadi literally means "woman" in Setswana, and she was given the English name "Muriel". Her father, Mokgosi II, expected a boy to be his oldest child, but upon seeing his daughter, he said, "Well, it's a woman. What can I do? It's my child." In 1969, she graduated from Moeding College. Two years later, she became the department administrator at Barclay's Bank. She ended her six-year marriage with her abusive husband in 1978.
