The 116th Regiment Indiana Infantry was an infantry regiment from Indiana that served in the Union Army during the American Civil War. The regiment was mustered into Federal service in August 1863 to serve for six months. It served in the Knoxville campaign in East Tennessee, fighting in actions at Blue Springs and Walker's Ford in 1863. The regiment was mustered out in March 1864 having lost 1 man dead from enemy action and 64 men dead from disease.
