Lefferts was executive producer and writer of the Smithsonian Institution Specials for David Wolper Productions, executive producer for Time-Life, NBC, ABC and CBS, and a frequent writer of original scripts and short stories for the science fiction radio programs Dimension X and X Minus One. He wrote and produced the anti-ageist film The Living End, of which Variety wrote "the writing by George Lefferts was so pure it was well nigh perfect." With Alfred Hitchcock and William Shatner he created and wrote Tactic the first television program to openly deal with cancer. He also created, produced and wrote NBC Specials for Women, a groundbreaking series for Women's Liberation featuring anthropologist Margaret Mead; the program won the Emmy Award (1967) and the Golden Globe Award (1968).
