Amukamara started the Giants' season-opener against the Dallas Cowboys and recorded a season-high eight combined tackles during a 26–27 loss. In Week 3, he made a season-high eight combined tackles, three pass deflections, and intercepted Washington Redskins' quarterback Kirk Cousins during a 32–21 victory. On October 11, 2015, he suffered an injury to his pectoral during a 30–27 victory over the San Francisco 49ers. Amukamara missed Week 6-10 due to the injury. In Week 15, he recorded a season-high seven solo tackles and defended two passes during a 35–38 loss to the Carolina Panthers. He started ten games in and appeared in 11, finishing with a total of 63 combined tackles (55 solo), ten pass deflections, an interception, and a forced fumble.
