Hagio's science fiction works depict themes and subjects typical of the genre, such as human cloning and time travel, but also take advantage of the genre's ability to depict worlds in which gender-based differences and power imbalances differ from that of the real word. Hagio's science fiction manga frequently explores topics relating to the place women in society, motherhood, and gender fluidity, taking particular inspiration from the works of Ursula K. Le Guin.
