In 1853, he married Ariana Randolph Wormeley (1833–1922) in Newport, a sister of Elizabeth Wormeley Latimer, both descendants of John Randolph (1727–1784). As Ariana's father was an officer in the Royal Navy, she was born and raised in London. They returned to the United States in 1848. Daniel and Ariana settled in Boston where their sons were born:
