The Mustangs finished the 2021–22 season 24–9, 13–4 in AAC play to finish in second place. They defeated Tulsa in the quarterfinals of the AAC tournament before losing to Memphis in the semifinals. They received an at-large bid to the National Invitation Tournament as a No. 1 seed. They defeated Nichols in the first round before losing to Washington State in the second round.
