Layton's main research interest is the application of mathematics to biological systems. She works with physiologists and clinicians to formulate detailed computational models of kidney function, which she uses to understand the impacts of diabetes and hypertension on kidney function, and the effectiveness of novel therapeutic treatments. With Aurélie Edwards, Layton is the author of Mathematical Modeling in Renal Physiology (Springer, Lecture Notes on Mathematical Modelling in the Life Sciences, 2014).
