Bed bug pesticide-resistance appears to be increasing dramatically. Bed bug populations sampled across the U.S. showed a tolerance for pyrethroids several thousand times greater than laboratory bed bugs.Voiland, Adam. "You May not be Alone" U.S. News & World Report 16 July 2007, Vol. 143, Issue 2, p53–54. New York City bed bugs have been found to be 264 times more resistant to deltamethrin than Florida bed bugs due to mutations and evolution."Biochemical and Molecular Analysis of Deltamethrin Resistance in the Common Bed Bug (Hemiptera: Cimicidae)" Journal of Medical Entomology,45 (6), 2008, pp. 1092–1101 Products developed in the mid 2010s combine neonicotinoids with pyrethroids, but according to a January 2016 survey published by the Journal of Medical Entomology, bed bug resistance in two major US cities now includes neonicotinoids.
