The Texas Tech Red Raiders faced the Iowa State Cyclones at the Jack Trice Stadium in Ames, Iowa for their second road game of the season. This game marked only the ninth time the two teams have met and the start of an annual conference series. The Red Raiders dominated the overall series heading into this matchup with a record of 7–1. However, the Red Raiders fell 52–38 to Iowa State marking their first loss to the Cyclones since 2002. Turnovers played a big role in this meeting as Texas Tech had three (two fumbles, one interception) while the Cyclones had none. A poor first half also contributed to the Red Raider loss.
