November 14, 2008: The No. 22 Bearcats, searching for their first Keg of Nails victory in six seasons, came to Louisville to take on a struggling Cardinals team. Cincinnati quarterback Tony Pike exited the game with an injury in the fourth quarter. The former starter, replaced by Pike after breaking his leg, Dustin Grutza entered the game and led the game winning, seventy-two yard drive for the Bearcats to win the game 28–20. The Bearcats would go onto win their first Big East conference title.
