US 250 meets the eastern end of US 250 Business and SR 20 (High Street) just before crossing the Rivanna River on the Free Bridge to re-enter Albemarle County. East of the river, SR 20 heads north as Stony Point Road and the highway, now named Richmond Road, passes through the suburban community of Pantops before another diamond interchange with I-64. US 250 continues as a two-lane road through Shadwell, the birthplace of Thomas Jefferson, where the highway intersects SR 22 (Louisa Road) and crosses over CSX's Piedmont Subdivision. The highway passes through far northern Fluvanna County before entering Louisa County at the highway's intersection with US 15 (James Madison Highway) at Zion Crossroads. US 250 continues as Three Notch Road through Ferncliff, where the highway meets the southern end of SR 208 (Courthouse Road). The highway briefly passes through the northeastern corner of Fluvanna County and enters Goochland County as Broad Street Road. US 250 re-enters Louisa County for an intersection with US 522 (Cross County Road) at Gum Spring, then re-enters Goochland County.
