Early in his comics career, MacIssac published gay male erotica. In 2006, he collaborated with writer Dale Lazarov on Sticky, a wordless graphic novel focusing on the sex lives of gay men. However, since 2006, he has focused on his series about gay men's relationships and experiences in the early twenty-first century, Shirtlifter (vols. 1 - 6). Shirtlifter is an anthology series in which MacIsaac has focused on creating short stories and serializing long-form comics work, such as his graphic novel, Unpacking.
