The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. The main functions are to enable mRNA 3’-UTR binding and make up the structure of the ribosome. It is also a part of peptide chain elongation and processes rRNA in the nucleus and cytosol. In yeast, the length of the UTRs are varied from other genes, with 18-22 nucleotides at the 5’ side and 203-210 on the 3’ side. The estimated time for translation of the L41 ribosome was calculated to be approximately 2 seconds in a study by Xiang Yu and Jonathan R. Warner. In the Variant viewer of the UniProt 60S ribosomal protein L41, 15 possible variants are shown from the amino acids in position 3 to 20. These changes are all by missense mutations of base substitution, except for one nonsense mutation with a stop codon added. The chart shows 14 of the variants as predicted to have a consequence and 1 variant uncertain. The most common amino acid change is from G to A and G to T. Other mutations observed were G to C, C to A, and A to C. There are no observed frameshift mutations of deletion or insertion, only amino acid changes. There is also no methylation seen in the interactions of the 60S ribosomal protein subunit L41. There is no drug resistance found for the mutations described. Although the gene is typically expressed, the deletion of the ribosomal protein L41 in yeast does not prevent the growth of the organism. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
