On 21 October 2020, Daddy Yankee, Anuel AA, and Kendo Kaponi debuted a new version of "Don Don" at the 2020 Billboard Latin Music Awards. The new version featured vocals by Sisqó, whose song "Thong Song" was sampled in "Don Don." In the new version, Sisqó blends in the lyrics to "Thong Song" over the instrumental for "Don Don." The Billboard performance of the remix was released online the day after the awards, and an official studio version was released weeks later on 5 November 2020.
