Playing in Paris at the WTA indoor event, Plíšková was defeated in the first round of qualifying by Lara Arruabarrena Vecino. Next, Plíšková played at a $25k tournament in Grenoble, France. She lost in the quarterfinals to Sandra Záhlavová. At the Dubai Championships, Plíšková was defeated in the first round of qualifying to Kurumi Nara. Seeded eighth at the Malaysian Open, she lost in the first round to qualifier Zarina Diyas. In Indian Wells, Plíšková was defeated in the first round of qualifying by American wildcard Grace Min. At the Miami Open, she lost in the final round of qualifying to Jana Čepelová. After that, Plíšková stayed in Florida to compete at the Oaks Club Challenger where she was beaten in her quarterfinal match by eventual finalist Estrella Cabeza Candela.
