Spencer gained industry fame when he teamed up with fellow 20th Century Fox orchestrator Earle Hagen in 1953 to create the Spencer-Hagen Orchestra. They recorded albums for an offshoot of the RCA label "X", and Liberty, and also formed a film scoring service called Music Scoring, Inc. (MSI). Spencer and Hagen scored many early sitcoms and other television shows, including The Danny Thomas Show, Where's Raymond?, renamed The Ray Bolger Show, It's Always Jan starring Janis Paige and My Sister Eileen. Earle wrote the underscore, while Herb wrote the arrangements. Occasionally, these chores overlapped, when time permitted. MSI was dissolved about 1960, and Spencer went on to score The Joey Bishop Show. Spencer also co-wrote "The Fishin' Hole", The Andy Griffith Show theme.
