US 65 originally entered North Little Rock via the Main Street Bridge and continued with northbound traffic along Main Street (with southbound traffic using Maple Street one block to the west), converging onto Main Street, and diverging from US 67 and US 70 by turning west onto 18th Street. The highway then turned northwest along the east side of the railroad, along what is now Percy Machin Drive, and paralleled the railroad into Conway. US 65 was later relocated west, following the Broadway Bridge to a west turn on Broadway, proceeding under a rail overpass to then turn north on Pike Avenue. As US 65 progressed into North Little Rock's Levy neighborhood, its alignment shifted east of the railroad along Pike Avenue, turning northwest along Parkway Drive to converge with its original route near the city's Amboy neighborhood. Later, the Levy-to-Amboy segment was relocated again along the west side of the railroad via MacArthur Drive, eventually converging with its original route. US 65 was finally relocated east, through downtown along Interstate 30, then following Interstate 40 to Conway.
