In 1519, he removed to Mainz at the request of Albrecht, archbishop of that city, who soon made him his chancellor. In 1523 he settled at Strasbourg, where he remained until his death in November 1541. He had found it increasingly difficult to reconcile the new religion with the old, and from 1524 was one of the leaders of the reformed faith in Strasbourg. He took a prominent part in the earlier ecclesiastical transactions of the 16th century, was present at the second conference of Zürich and at the conference of Marburg, and along with Martin Bucer drew up the Confessio Tetrapolitana.
