Mega Man Powered Up received generally positive reception after it was revealed. It was perceived initially as a "straight port" of the NES game with graphical enhancements. IGN writer Nix felt that the graphical update as seen at the 2005 Tokyo Game Show was well-designed. He noted that its biggest hang-up was the fact that the original Mega Man was improved upon by its sequels and that the original lacked functions such as the charge shot, the slide, and Rush. Jeff Gerstmann felt the game was promising and praised its take on the original levels as well as its level editor. Juan Castro felt that it would appeal to Mega Man fans and those looking for an "oldschool platformer."
