Mongol rule of the region continued until 1335, and this badly damaged both trade and agriculture, which had been the sources of the region's prosperity. The impact was felt hardest between 1260 and 1315, and traders essentially avoided the region because of ongoing war between Mamluk and Mongol forces. In 1315, the Il-Khanate and the Mamluks signed a treaty and trade restarted. This proved to be a boon for Hisn Kayfa. The previous primary routes across the region—through Cizre and Nusaybin, and through Mayafaraqin and Amida (Diyarbakır)—both failed to attract many traders, and a new route from Iran to Aleppo through Siirt, Hisn Kayfa and Mardin took their place.
