Rao was born on 1 July 1922 into a Madhwa Brahmin family. He completed his education from Mysore University. He worked in the Archaeological Department of Baroda State and subsequently served the Archaeological Survey of India in various capacities. Rao has led excavations of many important sites such as Rangpur, Amreli, Bhagatrav, Dwarka, Hanur, Aihole, Kaveripattinam and others. One of his most important works were leading the research and excavations at Lothal, the earliest known port in history and the most important Indus-era site in India. Rao was the recipient of Jawaharlal Nehru Fellowship and a doctorate of literature from Mysore University. Rao had supervised excavation of several historic sites across the country in the West and South.
