In several episodes of the animated Nickelodeon series The Loud House, Manzano provides the voice of Bobby and Ronnie Anne Santiago's grandmother, Rosa Casagrande, a role she reprises in the spinoff The Casagrandes. She also portrays Judge Gloria Pepitone in Law & Order: Special Victims Unit. She also provided the voice-over narration in several animated segments in the English version of the Swedish television show Fem myror är fler än fyra elefanter.
