The altarpiece over the main altar is The Crucifixion (1564-1565), by Girolamo Siciolante da Sermoneta. Funded by Prince Philip of Spain it was moved from San Giacomo degli Spagnoli.May, Rose Marie. "San Giacomo degli Spagnoli in Rome on the Forefront of Reform", Space, Image, and Reform in Early Modern Art, (Arthur J. DiFuria, Ian Verstegen, eds.) Walter de Gruyter GmbH & Co KG, 2021, p. 147 et seq
