Few of the games from the NES version of Action 52 appear in the Sega Genesis version; although many of the titles have been retained, the games themselves have been rebuilt from scratch for the most part. For example, Haunted Hills appears in both versions, but the player character's gender is different (female in the NES version and male in the Genesis version), as is the setting, which is inside a haunted house in the NES version, and outside of one in the Genesis version. In the Genesis version of The Cheetahmen, the titular characters rescue cheetah cubs from Dr. Morbis and his minions.
