Musically, "Blow Me (One Last Kiss)" is an upbeat electropop song. It has a length of four minutes and fifteen seconds (4:15). The song's instrumentation incorporates synthesizers, keyboards, bass drums, guitars, and sirens. Marc Hogan of Spin and Jonathan Bogart of The Atlantic both noted similarities between "Blow Me (One Last Kiss)" and Modest Mouse's 2004 song "Float On", referring to the "punchy" rock riffs used. According to the sheet music published at Musicnotes.com, the song is composed in the key of G Major and set in the time signature of common time with a moderate tempo of 116 beats per minute. The verses have a G–G–Bm–Em–C chord progression, and the chorus follows a G–Bm–Em–C sequence. Pink's vocal range spans from E to G.
