Aaron Bishop of Clash wrote that Port of Miami 2 "shows Renzel with his pen at his sharpest, his beats at their grandest and his coveted guest verse spots at their most impactful. Over a decade at the top of the rap mountain has seen the MMG icon have his ups and downs. But on what is his tenth studio album, he proves why he’s achieved such longevity in the fickle game that is rap. Tracks such as "Turnpike Ike" showcase the four-time Grammy nominee at his very best, while his willingness to delve into topics outside of his luxurious lifestyle add a depth and gravitas to the record that make it a worthy successor to the original thirteen years on." Andy Kellman of AllMusic saying "Frequent serious references to mortality make Port of Miami 2 his heaviest recording." Evan Rytlewski of Pitchfork stated: "Too often on Port of Miami 2, he locks into the flow of least resistance and simply lets it ride, hiding behind his production instead of asserting his dominion over it. And while his music remains sumptuous as always, that luster alone is no longer enough to wow."
