The Spokane and Inland Empire Railroad Company (S.&I.E.R.R.Co.) was an electrified interurban railway operating in Spokane, Washington and vicinity, extending into northern and central Idaho. The system originated in several predecessor roads beginning c. 1890, incorporated in 1904, and ran under its own name to 1929. It merged into the Great Northern Railway and later, the Burlington Northern Railroad, which operated some roads into the 1980s.
