2011 marked another successful year for Domingo wherein she starred in 9 local films. She was paired with matinee idol, Richard Gutierrez in "Gunaw" (Apocalypse) episode of a trilogy, My Valentine Girls. She was also cast as Belinda Eduque on Who's That Girl? and as Precy in Wedding Tayo, Wedding Hindi. According to a review from PEP, "She(Domingo) was still able to make the material fresh and entertaining. Her punch lines, although sometimes buried under long dialogues, and antics elicited laughter from viewers...". She also appeared on independent films, Zombadings 1: Patayin Sa Shokot Si Remington produced by Origin8media and Pisay produced by Cinemalaya. Domingo appeared on three films at the 2011 Metro Manila Film Festival through Enteng Ng Ina Mo, Shake, Rattle & Roll 13 and My House Husband: Ikaw Na! wherein she was honored another "Best Supporting Actress" award.
