He was later appointed board chairman of Ghana ports and Harbour Authority in 2013 under the regime of former president John Dramani Mahama. In November 2018, Ampofo was elected the National Chairman of the NDC at 9th delegate congress held at Fantasy Dome at the Trade Fair Centre in Accra. His contenders were Dan Abodakpi, Betty Mould Iddrisu, Alhaji Huudu Yahaya and Danny Annang.
