US 14 was signed later than the other U.S. Highways in Wisconsin, being opened in 1933. The route replaced the old versions of WIS 11, from La Crosse to Madison, WIS 13 from Madison to Evansville, WIS 92 into Janesville, and WIS 20 and WIS 89 from Janesville to Illinois. The older WIS 14 was in existence when US 14 was opened, that was redesignated as WIS 81 and WIS 15 (the latter being the present-day I-43).
