On 11 February 2022, Lo released the single "How Long" in promotion of the soundtrack to the second season of American teen drama Euphoria. On 3 May 2022 she released the single "No One Dies From Love" through her own label Pretty Swede Records, marking her debut as an independent artist after being signed to Island Records since 2014. On 21 June 2022 she announced that her fifth studio album Dirt Femme would be released on 14 October 2022. The album contains both "How Long" and "No One Dies from Love" as well as the single "True Romance". The track "Cute & Cruel" features the Swedish band First Aid Kit. Another single from this album, 2 Die 4, was released on 29 July 2022, which samples the melody of the 1969 hit Popcorn.
