She held several posts during the course of the Chavez administration: as International Affairs Director in the Ministry of Energy and Mines, in 2003; as Vice-minister for European Affairs in 2005; serving from February–August 2006 as the Minister for Presidential Affairs and the following year as General Coordinator to the Vice-President of Venezuela, both of which roles she held while her brother occupied the office of Vice President of the Republic. She was the Minister for Presidential Affairs in 2006. Similarly, she was Vice Minister for Europe at the Venezuelan Ministry of Foreign Relations. She also served as the General Coordinator to the Vice President of Venezuela. According to a profile published in the daily Tal Cual, Rodriguez pursued a concentration in labor law in Paris, France, taught at UCV and was a member of the Venezuelan Association of Labor Lawyers.
