Lepipre inherited some fortune at the death of his father, but at one time found himself considerably reduced in circumstances, and temporarily worked for Isaac Beckett the mezzotint-engraver. Late in life he took to modelling in wax, executing bas-reliefs in this manner with some success. After his mother's death he inherited further property, and indulged in free living again. A fever was the result, and through medical inexperience it proved fatal. He died unmarried in Aldermanbury in 1698, and was buried in St. Mary Magdalen, Bermondsey. Two portraits of Lepipre were engraved in mezzotint, one being ascribed to E. Luttrell; others were engraved for various editions of Walpole's Anecdotes of Painting. He also was the central figure of a group painted by Isaac Fuller. His brother, Peter Lepipre, was a merchant in London, and owned most of his brother's drawings. He married Sarah, daughter of Sir Gabriel Roberts, by whom he had a large family.
