Sinitsyna debuted her programs for the 2021–22 season at the 2021 Russian test skate event in early September, where she skated her short program cleanly but made several mistakes in her free program, including falling on an attempted quad toe loop. Sinitsyna and her team decided to remove the quad from her free skate in advance of her first Grand Prix assignment, the 2021 Skate America, due to an injury.
