For transgender women, taking estrogen stimulates the development of breast tissue, causing them to increase in both size and sensitivity. This increased sensitivity can be pleasurable, painful, or both, depending on the person and the type of stimulation. Furthermore, for those taking estrogen and who have male genitalia, estrogen can (and often does) shrink the external male genitalia and decrease the production of semen (at times bringing the sperm count to zero), and can decrease the ability for the male genitalia to become erect. In addition to these changes, some transgender women going through hormone therapy (HRT) can experience changes in the way their orgasms feel. For example, some people report the ability to experience multiple orgasms.
