Orszag specialized in fluid dynamics, especially turbulence, computational physics and mathematics, electronic chip manufacturing, computer storage system design, and other topics in scientific computing. His work included the development of spectral methods, pseudo-spectral methods, direct numerical simulations, renormalization group methods for turbulence, and very-large-eddy simulations. He was the founder of and/or chief scientific adviser to a number of companies, including Flow Research, Ibrix (now part of HPQ), Vector Technologies, and Exa Corp. He has been awarded 6 patents and has written over 400 archival papers.
