After graduation, he entered the Commons as MP for Calne in 1837. He served under Lord John Russell as a Lord of the Treasury from 1847 to 1848. In 1856, he was called up to the House of Lords in his father's barony of Wycombe and was Parliamentary Under-Secretary of State for Foreign Affairs under Lord Palmerston from that year until 1858. On the death of his father in 1863, Lord Shelburne succeeded to his titles and was made a Knight of the Garter a year later.
