Aaron Vanderpoel was the youngest of six children born in Kinderhook, New York to Isaac Vanderpoel (1747–1807) and Moyca Vanderpoel (née Huyck, 1758–1827): Anne Vanderpoel (1785–1787), James Vanderpoel (1787–1843), who married Anna Doll (1782–1855) on April 7, 1808 (their daughter, Elizabeth Vanderpoel (1814–1844), married John Van Buren (1810–1866), the second son of President Martin Van Buren), Anne Vanderpoel (1789-1793), Elizabeth Vanderpoel (1791–1833), who married Lucas J. Van Alen on January 16, 1815, John Vanderpoel (1796-1851), who married Sarah W. Oakley on January 14, 1823, and was a judge of the Superior Court in Albany, and Aaron Vanderpoel (1799–1870). Vanderpoel and most of his siblings were educated at Kinderhook Academy and Lenox Academy.
