Toughkenamon is located east of Pennsylvania Route 41 in Avondale on the old Baltimore Pike, a few miles west-southwest of Kennett Square. Interstate 95, U.S. 1, Pennsylvania 41, and U.S. 30 are used as approaches to Toughkenamon. The Philadelphia & Baltimore Central Railroad (now East Penn Railroad) parallels Baltimore Pike, originally crossing the Pennsylvania Rail Road in Avondale. East Penn Railroad now connects Toughkenamon to the national freight network at Chadd's Ford. New Garden Airport is to the northeast on Toughkenamon Hill.
