At the Mall of Asia Arena in November 2012, Velasquez headlined "Silver" but the show was cut short after she lost her voice because of a viral infection—it was re-staged in January 2013. From 2013 to 2016, she co-headlined annual concerts at the Mall of Asia Arena: "Foursome", "Voices of Love", "Ultimate" and "Royals". To promote her seventeenth studio album, R3.0 (2017), she staged a two-night show at the Mall of Asia Arena. In 2020, in support of relief efforts during the COVID-19 pandemic, Velasquez curated virtual benefit concerts "One Night with Regine" for Bantay Bata Foundation and "Regine: Joy From Home" for Jollibee Group Food Aid. She also released the single "Istorya", which she performed at the 25th Asian Television Awards and ASAP Natin 'To.
