In the 1930s, Acuff's investment company went bankrupt, and the Medical Arts Building was sold to the Metropolitan Life Insurance Company. In subsequent years, the building's first floor tenants have included a bank, a drug store and restaurant. In 1981, Knoxville-area developer Kristopher Kendrick purchased the building, and in turn sold it in 1983 to the Medical Arts Building Association, which renovated the building for modern office space.
