The presence of a single transverse palmar crease can be , but is not always , a symptom associated with abnormal medical conditions , such as fetal alcohol syndrome , or with genetic chromosomal abnormalities , including Down syndrome ( chromosome 21 ) , cri du chat syndrome ( chromosome 5 ) , Klinefelter syndrome , Wolf-Hirschhorn Syndrome , Noonan syndrome ( chromosome 12 ) , Patau syndrome ( chromosome 13 ) , IDIC 15/Dup15q ( chromosome 15 ) , Edward 's syndrome ( chromosome 18 ) , and Aarskog-Scott syndrome ( X-linked recessive ) , or autosomal recessive disorder , such as Leukocyte adhesion deficiency-2 ( LAD2 ) .
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