The commercial semisynthesis ( by Bristol-Myers Squibb ) of paclitaxel starting from 10-deacetylbaccatin III ( isolated from the European yew ) is based on tail addition of the so-called Ojima lactam to its free hydroxyl group :
DET ADJ NOUN ( ADP PROPN PROPN ) ADP NOUN VERB ADP NUM NUM ( VERB ADP DET ADJ NOUN ) AUX VERB ADP NOUN NOUN ADP DET VERB PROPN NOUN ADP PRON ADJ NOUN NOUN :