Protein C in plasma in the steady state has a half life of 6- to 10-hour , therefore , patients with severe protein C deficiency and presenting with purpura fulminans can be treated acutely with an initial bolus of protein C concentrate 100 IU/kg followed by 50 IU /kg every 6 hours .
NOUN PROPN ADP NOUN ADP DET ADJ NOUN VERB DET ADJ NOUN ADP NUM ADP NUM , ADV , NOUN ADP ADJ NOUN NOUN NOUN CCONJ VERB ADP NOUN NOUN AUX AUX VERB ADV ADP DET ADJ NOUN ADP NOUN NOUN NOUN NUM NOUN VERB ADP NUM NOUN INTJ DET NUM NOUN .