<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-124
Date of Submission: 2024-10-09

This report was submitted by a Pharmacist from Coleman, Parker and Williams Medical Center concerning patient ANON-PX-7651. The subject is an adult other with a significant medical history including osteoarthritis, chronic kidney disease, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Intravenous route at a dosage of 27mg, initiated on 2024-08-03 for Hypercholesterolemia and discontinued on 2024-10-07; Ibuprofen (NSAID) administered via the Topical route at a dosage of 460mg, initiated on 2024-08-03 for Pain and inflammation and discontinued on 2024-10-07.

On approximately 2024-09-15, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Stevens-Johnson syndrome, Somnolence, Hepatotoxicity. The Vomiting was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed save and advised blue. The current patient status regarding this symptom is 'Recovered'. The Stevens-Johnson syndrome was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Somnolence was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Hepatotoxicity was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed American and advised although. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 2 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Hold believe oil group anyone. Lose thousand need message food discussion.</data>
report_id: ADR-2024-124
report_date: '2024-10-09'
patient_details:
  patient_id: ANON-PX-7651
  gender: Other
  relevant_history:
  - osteoarthritis
  - chronic kidney disease
  - atrial fibrillation
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 27mg
  route_of_administration: Intravenous
  start_date: '2024-08-03'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
  end_date: '2024-10-07'
- drug_name: Ibuprofen
  dosage: 460mg
  route_of_administration: Topical
  start_date: '2024-08-03'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-10-07'
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2024-09-15'
  severity: Moderate
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed save and advised blue.
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-09-15'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Somnolence
  onset_date: '2024-09-15'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-09-15'
  severity: Mild
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed American and advised although.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 2
reporting_facility: Coleman, Parker and Williams Medical Center
reporter_type: Pharmacist
notes: Hold believe oil group anyone. Lose thousand need message food discussion.
