<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-627
Date of Submission: 2025-05-02

This report was submitted by a Nurse from Guzman Inc Medical Center concerning patient ANON-PX-8359. The subject is a 84-year-old other with a significant medical history including chronic kidney disease, seasonal allergies, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Sertraline (SSRI) administered via the Intravenous route at a dosage of 8mg, initiated on 2025-02-17 for Major depressive disorder and discontinued on 2025-04-09; Lisinopril (ACE inhibitor) administered via the Intravenous route at a dosage of 366mg, initiated on 2025-02-17 for Hypertension and discontinued on 2025-04-09.

On approximately 2025-04-09, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Dizziness, Hepatotoxicity. The Dizziness was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Hepatotoxicity was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Appear heart resource reach break movie write stand.</data>
report_id: ADR-2025-627
report_date: '2025-05-02'
patient_details:
  patient_id: ANON-PX-8359
  gender: Other
  relevant_history:
  - chronic kidney disease
  - seasonal allergies
  - asthma
  age_at_reaction: 84
suspected_drugs:
- drug_name: Sertraline
  dosage: 8mg
  route_of_administration: Intravenous
  start_date: '2025-02-17'
  indication_for_use: Major depressive disorder
  drug_class: SSRI
  end_date: '2025-04-09'
- drug_name: Lisinopril
  dosage: 366mg
  route_of_administration: Intravenous
  start_date: '2025-02-17'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2025-04-09'
adverse_reactions:
- symptom_name: Dizziness
  onset_date: '2025-04-09'
  severity: Moderate
  outcome: Fatal
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2025-04-09'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
reporting_facility: Guzman Inc Medical Center
reporter_type: Nurse
notes: Appear heart resource reach break movie write stand.
