<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-502
Date of Submission: 2024-09-03

This report was submitted by a Patient from Cochran LLC Medical Center concerning patient ANON-PX-3943. The subject is an adult male with a significant medical history including coronary artery disease, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin (Penicillin antibiotic) administered via the Topical route at a dosage of 182mg, initiated on 2024-07-18 for Bacterial infection and discontinued on 2024-08-20.

On approximately 2024-08-14, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Diarrhea, Maculopapular Rash, Headache, Anaphylaxis, Angioedema. The Diarrhea was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Maculopapular Rash was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed service and advised different. The current patient status regarding this symptom is 'Recovering'. The Headache was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed young and advised certain. The current patient status regarding this symptom is 'Recovered'. The Anaphylaxis was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed choice and advised particularly. The current patient status regarding this symptom is 'Fatal'. The Angioedema was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 3 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Dinner smile firm mouth. Around account stand late can such appear. My leave fish.</data>
report_id: ADR-2024-502
report_date: '2024-09-03'
patient_details:
  patient_id: ANON-PX-3943
  gender: Male
  relevant_history:
  - coronary artery disease
  - atrial fibrillation
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 182mg
  route_of_administration: Topical
  start_date: '2024-07-18'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
  end_date: '2024-08-20'
adverse_reactions:
- symptom_name: Diarrhea
  onset_date: '2024-08-14'
  severity: Mild
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Maculopapular Rash
  onset_date: '2024-08-14'
  severity: Severe
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed service and advised different.
- symptom_name: Headache
  onset_date: '2024-08-14'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed young and advised certain.
- symptom_name: Anaphylaxis
  onset_date: '2024-08-14'
  severity: Severe
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed choice and advised particularly.
- symptom_name: Angioedema
  onset_date: '2024-08-14'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: true
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Not applicable
  naranjo_score: 3
reporting_facility: Cochran LLC Medical Center
reporter_type: Patient
notes: Dinner smile firm mouth. Around account stand late can such appear. My leave
  fish.
