<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-675
Date of Submission: 2024-09-18

This report was submitted by a Pharmacist from Sanchez PLC Medical Center concerning patient ANON-PX-1879. The subject is a 21-year-old male with a significant medical history including seasonal allergies, anxiety, asthma, osteoarthritis. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin (Penicillin antibiotic) administered via the Intravenous route at a dosage of 77mg, initiated on 2024-08-28 for Bacterial infection with the course ongoing; Ibuprofen (NSAID) administered via the Topical route at a dosage of 290mg, initiated on 2024-08-28 for Pain and inflammation with the course ongoing.

On approximately 2024-09-07, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Angioedema. The Vomiting was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed certainly and advised outside. The current patient status regarding this symptom is 'Recovering'. The Angioedema was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed there and advised land. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 2 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Within catch describe fly over future general. Quite area leave against begin great protect.</data>
report_id: ADR-2024-675
report_date: '2024-09-18'
patient_details:
  patient_id: ANON-PX-1879
  gender: Male
  relevant_history:
  - seasonal allergies
  - anxiety
  - asthma
  - osteoarthritis
  age_at_reaction: 21
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 77mg
  route_of_administration: Intravenous
  start_date: '2024-08-28'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
- drug_name: Ibuprofen
  dosage: 290mg
  route_of_administration: Topical
  start_date: '2024-08-28'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2024-09-07'
  severity: Moderate
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed certainly and advised outside.
- symptom_name: Angioedema
  onset_date: '2024-09-07'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed there and advised land.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Positive dechallenge
  naranjo_score: 2
reporting_facility: Sanchez PLC Medical Center
reporter_type: Pharmacist
notes: Within catch describe fly over future general. Quite area leave against begin
  great protect.
