<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-130
Date of Submission: 2024-10-04

This report was submitted by a Nurse from Smith, Smith and Mclaughlin Medical Center concerning patient ANON-PX-5745. The subject is an adult other with a significant medical history including migraines, hypertension. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril administered via the Intravenous route at a dosage of 298mg, initiated on 2024-07-08 for Hypertension and discontinued on 2024-09-02.

On approximately 2024-08-30, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Somnolence, Diarrhea, Stevens-Johnson syndrome, Hepatotoxicity, Dizziness. The Somnolence was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Diarrhea was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Stevens-Johnson syndrome was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed contain and advised place. The current patient status regarding this symptom is 'Not Recovered'. The Hepatotoxicity was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Dizziness was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 3 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Huge individual sound can be. Relationship discover more cup power message.</data>
report_id: ADR-2024-130
report_date: '2024-10-04'
patient_details:
  patient_id: ANON-PX-5745
  gender: Other
  relevant_history:
  - migraines
  - hypertension
suspected_drugs:
- drug_name: Lisinopril
  dosage: 298mg
  route_of_administration: Intravenous
  start_date: '2024-07-08'
  indication_for_use: Hypertension
  end_date: '2024-09-02'
adverse_reactions:
- symptom_name: Somnolence
  onset_date: '2024-08-30'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2024-08-30'
  severity: Mild
  outcome: Recovering
  intervention_required: false
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-08-30'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed contain and advised place.
- symptom_name: Hepatotoxicity
  onset_date: '2024-08-30'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2024-08-30'
  severity: Severe
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 3
reporting_facility: Smith, Smith and Mclaughlin Medical Center
reporter_type: Nurse
notes: Huge individual sound can be. Relationship discover more cup power message.
