<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-463
Date of Submission: 2024-12-17

This report was submitted by a Patient from Anderson, Brown and Johnson Medical Center concerning patient ANON-PX-4075. The subject is a 77-year-old other with a significant medical history including migraines, chronic kidney disease, osteoarthritis, hypertension. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Warfarin (Anticoagulant) administered via the Subcutaneous route at a dosage of 322mg, initiated on 2024-12-09 for Thromboembolism prevention and discontinued on 2024-12-15; Ibuprofen (NSAID) administered via the Subcutaneous route at a dosage of 225mg, initiated on 2024-12-09 for Pain and inflammation and discontinued on 2024-12-15.

On approximately 2024-12-13, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Pruritus, Anaphylaxis, Somnolence, Stevens-Johnson syndrome, Headache. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Anaphylaxis was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed board and advised act. The current patient status regarding this symptom is 'Fatal'. The Somnolence was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed man and advised simple. The current patient status regarding this symptom is 'Not Recovered'. The Stevens-Johnson syndrome was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed item and advised thing. The current patient status regarding this symptom is 'Recovered'. The Headache was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-463
report_date: '2024-12-17'
patient_details:
  patient_id: ANON-PX-4075
  gender: Other
  relevant_history:
  - migraines
  - chronic kidney disease
  - osteoarthritis
  - hypertension
  age_at_reaction: 77
suspected_drugs:
- drug_name: Warfarin
  dosage: 322mg
  route_of_administration: Subcutaneous
  start_date: '2024-12-09'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
  end_date: '2024-12-15'
- drug_name: Ibuprofen
  dosage: 225mg
  route_of_administration: Subcutaneous
  start_date: '2024-12-09'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-12-15'
adverse_reactions:
- symptom_name: Pruritus
  onset_date: '2024-12-13'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
- symptom_name: Anaphylaxis
  onset_date: '2024-12-13'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed board and advised act.
- symptom_name: Somnolence
  onset_date: '2024-12-13'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed man and advised simple.
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-12-13'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed item and advised thing.
- symptom_name: Headache
  onset_date: '2024-12-13'
  severity: Mild
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
reporting_facility: Anderson, Brown and Johnson Medical Center
reporter_type: Patient
