<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-581
Date of Submission: 2025-03-23

This report was submitted by a Physician from Ford Group Medical Center concerning patient ANON-PX-2620. The subject is an adult male with a significant medical history including migraines, osteoarthritis, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Oral route at a dosage of 165mg, initiated on 2024-12-31 for Hypertension with the course ongoing; Ibuprofen (NSAID) administered via the Intramuscular route at a dosage of 485mg, initiated on 2024-12-31 for Pain and inflammation with the course ongoing.

On approximately 2025-01-18, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Nausea, Dizziness, Vomiting, Diarrhea, Pruritus. The Nausea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Dizziness was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Vomiting was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Diarrhea was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Pruritus was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 3 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Size hotel state sea involve create office. Eat bag child standard career old woman bag. Someone board unit agreement the similar.</data>
report_id: ADR-2025-581
report_date: '2025-03-23'
patient_details:
  patient_id: ANON-PX-2620
  gender: Male
  relevant_history:
  - migraines
  - osteoarthritis
  - seasonal allergies
suspected_drugs:
- drug_name: Lisinopril
  dosage: 165mg
  route_of_administration: Oral
  start_date: '2024-12-31'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
- drug_name: Ibuprofen
  dosage: 485mg
  route_of_administration: Intramuscular
  start_date: '2024-12-31'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
adverse_reactions:
- symptom_name: Nausea
  onset_date: '2025-01-18'
  severity: Moderate
  outcome: Recovered
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2025-01-18'
  severity: Mild
  outcome: Unknown
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2025-01-18'
  severity: Moderate
  outcome: Fatal
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2025-01-18'
  severity: Moderate
  outcome: Recovered
  intervention_required: true
- symptom_name: Pruritus
  onset_date: '2025-01-18'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 3
reporting_facility: Ford Group Medical Center
reporter_type: Physician
notes: Size hotel state sea involve create office. Eat bag child standard career old
  woman bag. Someone board unit agreement the similar.
