<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-287
Date of Submission: 2024-10-23

This report was submitted by a Other Healthcare Professional from Randolph, Fitzgerald and Rios Medical Center concerning patient ANON-PX-3958. The subject is an adult female with a significant medical history including type 2 diabetes, asthma, atrial fibrillation, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin administered via the Subcutaneous route at a dosage of 101mg, initiated on 2024-10-05 for Hypercholesterolemia and discontinued on 2024-10-12; Ibuprofen (NSAID) administered via the Intravenous route at a dosage of 478mg, initiated on 2024-10-05 for Pain and inflammation and discontinued on 2024-10-12.

On approximately 2024-10-06, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Dizziness, Pruritus, Diarrhea, Anaphylaxis, Hepatotoxicity. The Dizziness was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Pruritus was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Diarrhea was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed entire and advised wife. The current patient status regarding this symptom is 'Recovering'. The Anaphylaxis was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed decide and advised great. The current patient status regarding this symptom is 'Recovered'. The Hepatotoxicity was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 4 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Hair from I describe road modern find. Always teach both inside wind. Practice within director through attention.</data>
report_id: ADR-2024-287
report_date: '2024-10-23'
patient_details:
  patient_id: ANON-PX-3958
  gender: Female
  relevant_history:
  - type 2 diabetes
  - asthma
  - atrial fibrillation
  - seasonal allergies
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 101mg
  route_of_administration: Subcutaneous
  start_date: '2024-10-05'
  indication_for_use: Hypercholesterolemia
  end_date: '2024-10-12'
- drug_name: Ibuprofen
  dosage: 478mg
  route_of_administration: Intravenous
  start_date: '2024-10-05'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-10-12'
adverse_reactions:
- symptom_name: Dizziness
  onset_date: '2024-10-06'
  severity: Severe
  outcome: Unknown
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2024-10-06'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2024-10-06'
  severity: Moderate
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed entire and advised wife.
- symptom_name: Anaphylaxis
  onset_date: '2024-10-06'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed decide and advised great.
- symptom_name: Hepatotoxicity
  onset_date: '2024-10-06'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 4
reporting_facility: Randolph, Fitzgerald and Rios Medical Center
reporter_type: Other Healthcare Professional
notes: Hair from I describe road modern find. Always teach both inside wind. Practice
  within director through attention.
