<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-776
Date of Submission: 2024-11-28

This report was submitted by a Other Healthcare Professional from Carpenter-Ryan Medical Center concerning patient ANON-PX-6925. The subject is a 37-year-old other with a significant medical history including type 2 diabetes, migraines, chronic kidney disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen administered via the Intravenous route at a dosage of 75mg, initiated on 2024-09-16 for Pain and inflammation with the course ongoing.

On approximately 2024-11-17, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Nausea, Diarrhea, Pruritus. The Vomiting was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed understand and advised affect. The current patient status regarding this symptom is 'Unknown'. The Nausea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Diarrhea was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Mouth college she movement structure sister between. Front radio laugh beyond than surface relationship drop.</data>
report_id: ADR-2024-776
report_date: '2024-11-28'
patient_details:
  patient_id: ANON-PX-6925
  gender: Other
  relevant_history:
  - type 2 diabetes
  - migraines
  - chronic kidney disease
  age_at_reaction: 37
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 75mg
  route_of_administration: Intravenous
  start_date: '2024-09-16'
  indication_for_use: Pain and inflammation
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2024-11-17'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed understand and advised affect.
- symptom_name: Nausea
  onset_date: '2024-11-17'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2024-11-17'
  severity: Mild
  outcome: Unknown
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2024-11-17'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Carpenter-Ryan Medical Center
reporter_type: Other Healthcare Professional
notes: Mouth college she movement structure sister between. Front radio laugh beyond
  than surface relationship drop.
