<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-458
Date of Submission: 2025-02-21

This report was submitted by a Pharmacist from Wilkerson and Sons Medical Center concerning patient ANON-PX-5990. The subject is an adult female with a significant medical history including asthma, osteoarthritis, seasonal allergies, hypertension. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Warfarin (Anticoagulant) administered via the Intravenous route at a dosage of 496mg, initiated on 2025-01-03 for Thromboembolism prevention and discontinued on 2025-02-20.

On approximately 2025-02-15, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Nausea, Pruritus, Maculopapular Rash. The Angioedema was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed control and advised hundred. The current patient status regarding this symptom is 'Unknown'. The Nausea was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed pattern and advised everybody. The current patient status regarding this symptom is 'Not Recovered'. The Pruritus was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Maculopapular Rash was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed well and advised personal. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 4 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-458
report_date: '2025-02-21'
patient_details:
  patient_id: ANON-PX-5990
  gender: Female
  relevant_history:
  - asthma
  - osteoarthritis
  - seasonal allergies
  - hypertension
suspected_drugs:
- drug_name: Warfarin
  dosage: 496mg
  route_of_administration: Intravenous
  start_date: '2025-01-03'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
  end_date: '2025-02-20'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2025-02-15'
  severity: Severe
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed control and advised hundred.
- symptom_name: Nausea
  onset_date: '2025-02-15'
  severity: Severe
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed pattern and advised everybody.
- symptom_name: Pruritus
  onset_date: '2025-02-15'
  severity: Mild
  outcome: Fatal
  intervention_required: false
- symptom_name: Maculopapular Rash
  onset_date: '2025-02-15'
  severity: Severe
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed well and advised personal.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 4
reporting_facility: Wilkerson and Sons Medical Center
reporter_type: Pharmacist
