<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-126
Date of Submission: 2025-03-31

This report was submitted by a Pharmacist from Woodward, Molina and Butler Medical Center concerning patient ANON-PX-7118. The subject is a 39-year-old female with a significant medical history including anxiety, migraines, chronic kidney disease, coronary artery disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen administered via the Intramuscular route at a dosage of 30mg, initiated on 2025-01-28 for Pain and inflammation and discontinued on 2025-03-21.

On approximately 2025-03-21, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Diarrhea, Maculopapular Rash, Angioedema. The Hepatotoxicity was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed because and advised exactly. The current patient status regarding this symptom is 'Recovered'. The Diarrhea was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed high and advised direction. The current patient status regarding this symptom is 'Recovering'. The Maculopapular Rash was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Angioedema was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 1 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-126
report_date: '2025-03-31'
patient_details:
  patient_id: ANON-PX-7118
  gender: Female
  relevant_history:
  - anxiety
  - migraines
  - chronic kidney disease
  - coronary artery disease
  age_at_reaction: 39
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 30mg
  route_of_administration: Intramuscular
  start_date: '2025-01-28'
  indication_for_use: Pain and inflammation
  end_date: '2025-03-21'
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2025-03-21'
  severity: Mild
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed because and advised exactly.
- symptom_name: Diarrhea
  onset_date: '2025-03-21'
  severity: Mild
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed high and advised direction.
- symptom_name: Maculopapular Rash
  onset_date: '2025-03-21'
  severity: Severe
  outcome: Unknown
  intervention_required: false
- symptom_name: Angioedema
  onset_date: '2025-03-21'
  severity: Severe
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Not applicable
  naranjo_score: 1
reporting_facility: Woodward, Molina and Butler Medical Center
reporter_type: Pharmacist
