<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-941
Date of Submission: 2024-10-16

This report was submitted by a Pharmacist from Guzman and Sons Medical Center concerning patient ANON-PX-9747. The subject is an adult other with a significant medical history including type 2 diabetes, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Topical route at a dosage of 100mg, initiated on 2024-08-03 for Hypercholesterolemia and discontinued on 2024-08-26; Levothyroxine (Thyroid hormone) administered via the Intramuscular route at a dosage of 171mg, initiated on 2024-08-03 for Hypothyroidism and discontinued on 2024-08-26.

On approximately 2024-08-21, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Pruritus, Diarrhea, Angioedema. The Pruritus was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed protect and advised better. The current patient status regarding this symptom is 'Recovered'. The Diarrhea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Angioedema was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed summer and advised thank. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 5 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

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report_id: ADR-2024-941
report_date: '2024-10-16'
patient_details:
  patient_id: ANON-PX-9747
  gender: Other
  relevant_history:
  - type 2 diabetes
  - seasonal allergies
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 100mg
  route_of_administration: Topical
  start_date: '2024-08-03'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
  end_date: '2024-08-26'
- drug_name: Levothyroxine
  dosage: 171mg
  route_of_administration: Intramuscular
  start_date: '2024-08-03'
  indication_for_use: Hypothyroidism
  drug_class: Thyroid hormone
  end_date: '2024-08-26'
adverse_reactions:
- symptom_name: Pruritus
  onset_date: '2024-08-21'
  severity: Severe
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed protect and advised better.
- symptom_name: Diarrhea
  onset_date: '2024-08-21'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Angioedema
  onset_date: '2024-08-21'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed summer and advised thank.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 5
reporting_facility: Guzman and Sons Medical Center
reporter_type: Pharmacist
notes: Rise everyone measure board measure structure create. Three without suggest
  rather back reach each today. Small front where magazine include determine.
