<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-217
Date of Submission: 2025-04-15

This report was submitted by a Patient from Fowler-Wilson Medical Center concerning patient ANON-PX-9918. The subject is a 78-year-old male with a significant medical history including asthma, migraines, anxiety, chronic kidney disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Oral route at a dosage of 432mg, initiated on 2025-02-06 for Pain and inflammation with the course ongoing.

On approximately 2025-03-17, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Diarrhea, Anaphylaxis, Headache. The Maculopapular Rash was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed space and advised several. The current patient status regarding this symptom is 'Unknown'. The Diarrhea was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed official and advised kitchen. The current patient status regarding this symptom is 'Recovering'. The Anaphylaxis was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Headache was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 7 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-217
report_date: '2025-04-15'
patient_details:
  patient_id: ANON-PX-9918
  gender: Male
  relevant_history:
  - asthma
  - migraines
  - anxiety
  - chronic kidney disease
  age_at_reaction: 78
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 432mg
  route_of_administration: Oral
  start_date: '2025-02-06'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2025-03-17'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed space and advised several.
- symptom_name: Diarrhea
  onset_date: '2025-03-17'
  severity: Severe
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed official and advised kitchen.
- symptom_name: Anaphylaxis
  onset_date: '2025-03-17'
  severity: Moderate
  outcome: Unknown
  intervention_required: false
- symptom_name: Headache
  onset_date: '2025-03-17'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 7
reporting_facility: Fowler-Wilson Medical Center
reporter_type: Patient
