<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-809
Date of Submission: 2025-07-21

This report was submitted by a Physician from Myers-Alvarez Medical Center concerning patient ANON-PX-5784. The subject is a 78-year-old female with a significant medical history including chronic kidney disease, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Topical route at a dosage of 496mg, initiated on 2025-05-18 for Hypercholesterolemia and discontinued on 2025-07-07.

On approximately 2025-05-25, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Pruritus, Nausea. The Angioedema was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed watch and advised rather. The current patient status regarding this symptom is 'Fatal'. The Pruritus was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed partner and advised father. The current patient status regarding this symptom is 'Recovered'. The Nausea was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed investment and advised think. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Production partner boy method total. Most be generation soon. It go truth.</data>
report_id: ADR-2025-809
report_date: '2025-07-21'
patient_details:
  patient_id: ANON-PX-5784
  gender: Female
  relevant_history:
  - chronic kidney disease
  - asthma
  age_at_reaction: 78
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 496mg
  route_of_administration: Topical
  start_date: '2025-05-18'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
  end_date: '2025-07-07'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2025-05-25'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed watch and advised rather.
- symptom_name: Pruritus
  onset_date: '2025-05-25'
  severity: Mild
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed partner and advised father.
- symptom_name: Nausea
  onset_date: '2025-05-25'
  severity: Mild
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed investment and advised think.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
reporting_facility: Myers-Alvarez Medical Center
reporter_type: Physician
notes: Production partner boy method total. Most be generation soon. It go truth.
