<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-928
Date of Submission: 2024-12-11

This report was submitted by a Other Healthcare Professional from Wilson, Hall and Velazquez Medical Center concerning patient ANON-PX-6943. The subject is an adult other with a significant medical history including seasonal allergies, anxiety. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Subcutaneous route at a dosage of 379mg, initiated on 2024-10-22 for Pain and inflammation with the course ongoing; Warfarin (Anticoagulant) administered via the Topical route at a dosage of 137mg, initiated on 2024-10-22 for Thromboembolism prevention with the course ongoing.

On approximately 2024-11-04, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Anaphylaxis, Angioedema, Maculopapular Rash, Vomiting, Headache. The Anaphylaxis was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Angioedema was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed close and advised start. The current patient status regarding this symptom is 'Recovering'. The Maculopapular Rash was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Vomiting was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed figure and advised want. The current patient status regarding this symptom is 'Recovering'. The Headache was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-928
report_date: '2024-12-11'
patient_details:
  patient_id: ANON-PX-6943
  gender: Other
  relevant_history:
  - seasonal allergies
  - anxiety
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 379mg
  route_of_administration: Subcutaneous
  start_date: '2024-10-22'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
- drug_name: Warfarin
  dosage: 137mg
  route_of_administration: Topical
  start_date: '2024-10-22'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
adverse_reactions:
- symptom_name: Anaphylaxis
  onset_date: '2024-11-04'
  severity: Moderate
  outcome: Recovered
  intervention_required: true
- symptom_name: Angioedema
  onset_date: '2024-11-04'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed close and advised start.
- symptom_name: Maculopapular Rash
  onset_date: '2024-11-04'
  severity: Mild
  outcome: Recovered
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2024-11-04'
  severity: Severe
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed figure and advised want.
- symptom_name: Headache
  onset_date: '2024-11-04'
  severity: Moderate
  outcome: Recovering
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Wilson, Hall and Velazquez Medical Center
reporter_type: Other Healthcare Professional
