<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-440
Date of Submission: 2024-10-02

This report was submitted by a Nurse from Clark, Contreras and Smith Medical Center concerning patient ANON-PX-2199. The subject is a 54-year-old other with a significant medical history including hypertension, osteoarthritis, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Topical route at a dosage of 370mg, initiated on 2024-09-10 for Hypertension and discontinued on 2024-09-25.

On approximately 2024-09-22, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Vomiting. The Hepatotoxicity was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Vomiting was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed treat and advised party. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 2 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Than quite any. Color compare member. Force war American majority not federal.</data>
report_id: ADR-2024-440
report_date: '2024-10-02'
patient_details:
  patient_id: ANON-PX-2199
  gender: Other
  relevant_history:
  - hypertension
  - osteoarthritis
  - asthma
  age_at_reaction: 54
suspected_drugs:
- drug_name: Lisinopril
  dosage: 370mg
  route_of_administration: Topical
  start_date: '2024-09-10'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2024-09-25'
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2024-09-22'
  severity: Mild
  outcome: Recovered
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2024-09-22'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed treat and advised party.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 2
reporting_facility: Clark, Contreras and Smith Medical Center
reporter_type: Nurse
notes: Than quite any. Color compare member. Force war American majority not federal.
