<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-944
Date of Submission: 2024-10-25

This report was submitted by a Patient from Kirk-Rangel Medical Center concerning patient ANON-PX-2802. The subject is a 79-year-old male with a significant medical history including chronic kidney disease, atrial fibrillation, coronary artery disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Sertraline (SSRI) administered via the Intravenous route at a dosage of 150mg, initiated on 2024-07-27 for Major depressive disorder and discontinued on 2024-10-21; Lisinopril (ACE inhibitor) administered via the Topical route at a dosage of 16mg, initiated on 2024-07-27 for Hypertension and discontinued on 2024-10-21.

On approximately 2024-10-16, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Pruritus. The Angioedema was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Pruritus was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 1 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Land he option sing manage night charge. Try store skill speak decade another.</data>
report_id: ADR-2024-944
report_date: '2024-10-25'
patient_details:
  patient_id: ANON-PX-2802
  gender: Male
  relevant_history:
  - chronic kidney disease
  - atrial fibrillation
  - coronary artery disease
  age_at_reaction: 79
suspected_drugs:
- drug_name: Sertraline
  dosage: 150mg
  route_of_administration: Intravenous
  start_date: '2024-07-27'
  indication_for_use: Major depressive disorder
  drug_class: SSRI
  end_date: '2024-10-21'
- drug_name: Lisinopril
  dosage: 16mg
  route_of_administration: Topical
  start_date: '2024-07-27'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2024-10-21'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2024-10-16'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2024-10-16'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 1
reporting_facility: Kirk-Rangel Medical Center
reporter_type: Patient
notes: Land he option sing manage night charge. Try store skill speak decade another.
