<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-203
Date of Submission: 2024-08-16

This report was submitted by a Other Healthcare Professional from Ortiz, Price and Reyes Medical Center concerning patient ANON-PX-1486. The subject is an adult other with a significant medical history including hypertension, chronic kidney disease, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril administered via the Oral route at a dosage of 146mg, initiated on 2024-06-29 for Hypertension with the course ongoing; Ibuprofen (NSAID) administered via the Intramuscular route at a dosage of 334mg, initiated on 2024-06-29 for Pain and inflammation with the course ongoing.

On approximately 2024-06-30, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Headache, Anaphylaxis, Somnolence, Stevens-Johnson syndrome. The Vomiting was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Not Recovered'. The Headache was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed price and advised compare. The current patient status regarding this symptom is 'Unknown'. The Anaphylaxis was classified as Mild in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Somnolence was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Stevens-Johnson syndrome was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 3 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-203
report_date: '2024-08-16'
patient_details:
  patient_id: ANON-PX-1486
  gender: Other
  relevant_history:
  - hypertension
  - chronic kidney disease
  - seasonal allergies
suspected_drugs:
- drug_name: Lisinopril
  dosage: 146mg
  route_of_administration: Oral
  start_date: '2024-06-29'
  indication_for_use: Hypertension
- drug_name: Ibuprofen
  dosage: 334mg
  route_of_administration: Intramuscular
  start_date: '2024-06-29'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2024-06-30'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: true
- symptom_name: Headache
  onset_date: '2024-06-30'
  severity: Mild
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed price and advised compare.
- symptom_name: Anaphylaxis
  onset_date: '2024-06-30'
  severity: Mild
  outcome: Recovered
  intervention_required: true
- symptom_name: Somnolence
  onset_date: '2024-06-30'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-06-30'
  severity: Severe
  outcome: Not Recovered
  intervention_required: true
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Not applicable
  naranjo_score: 3
reporting_facility: Ortiz, Price and Reyes Medical Center
reporter_type: Other Healthcare Professional
