<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-712
Date of Submission: 2025-02-10

This report was submitted by a Patient from Ayers-Palmer Medical Center concerning patient ANON-PX-5580. The subject is an adult male with a significant medical history including seasonal allergies, migraines. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Levothyroxine (Thyroid hormone) administered via the Intravenous route at a dosage of 306mg, initiated on 2024-11-24 for Hypothyroidism with the course ongoing.

On approximately 2024-12-17, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Angioedema. The Hepatotoxicity was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Angioedema was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 1 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Week agency know maintain put call edge. Increase door here today. Trip new relationship create notice agreement.</data>
report_id: ADR-2025-712
report_date: '2025-02-10'
patient_details:
  patient_id: ANON-PX-5580
  gender: Male
  relevant_history:
  - seasonal allergies
  - migraines
suspected_drugs:
- drug_name: Levothyroxine
  dosage: 306mg
  route_of_administration: Intravenous
  start_date: '2024-11-24'
  indication_for_use: Hypothyroidism
  drug_class: Thyroid hormone
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2024-12-17'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
- symptom_name: Angioedema
  onset_date: '2024-12-17'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Not applicable
  naranjo_score: 1
reporting_facility: Ayers-Palmer Medical Center
reporter_type: Patient
notes: Week agency know maintain put call edge. Increase door here today. Trip new
  relationship create notice agreement.
