<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-743
Date of Submission: 2025-02-18

This report was submitted by a Patient from Roberts-Wells Medical Center concerning patient ANON-PX-6005. The subject is a 72-year-old male with a significant medical history including seasonal allergies, osteoarthritis, migraines. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril administered via the Topical route at a dosage of 22mg, initiated on 2024-12-16 for Hypertension and discontinued on 2025-02-10.

On approximately 2025-01-08, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Hepatotoxicity, Diarrhea. The Stevens-Johnson syndrome was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Hepatotoxicity was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Diarrhea was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed guy and advised face. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 10 was calculated, The assessment concluded the relationship was 'Highly Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-743
report_date: '2025-02-18'
patient_details:
  patient_id: ANON-PX-6005
  gender: Male
  relevant_history:
  - seasonal allergies
  - osteoarthritis
  - migraines
  age_at_reaction: 72
suspected_drugs:
- drug_name: Lisinopril
  dosage: 22mg
  route_of_administration: Topical
  start_date: '2024-12-16'
  indication_for_use: Hypertension
  end_date: '2025-02-10'
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2025-01-08'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2025-01-08'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2025-01-08'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed guy and advised face.
causality_assessment:
  assessment_conclusion: Highly Probable
  dechallenge_rechallenge: Positive dechallenge
  naranjo_score: 10
reporting_facility: Roberts-Wells Medical Center
reporter_type: Patient
