<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-616
Date of Submission: 2025-02-28

This report was submitted by a Other Healthcare Professional from Campbell Ltd Medical Center concerning patient ANON-PX-4829. The subject is an adult other with a significant medical history including chronic kidney disease, asthma, seasonal allergies, type 2 diabetes. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Oral route at a dosage of 112mg, initiated on 2025-02-12 for Pain and inflammation with the course ongoing; Amoxicillin (Penicillin antibiotic) administered via the Oral route at a dosage of 114mg, initiated on 2025-02-12 for Bacterial infection with the course ongoing.

On approximately 2025-02-24, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Dizziness. The Hepatotoxicity was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Dizziness was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-616
report_date: '2025-02-28'
patient_details:
  patient_id: ANON-PX-4829
  gender: Other
  relevant_history:
  - chronic kidney disease
  - asthma
  - seasonal allergies
  - type 2 diabetes
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 112mg
  route_of_administration: Oral
  start_date: '2025-02-12'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
- drug_name: Amoxicillin
  dosage: 114mg
  route_of_administration: Oral
  start_date: '2025-02-12'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2025-02-24'
  severity: Severe
  outcome: Recovering
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2025-02-24'
  severity: Mild
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
reporting_facility: Campbell Ltd Medical Center
reporter_type: Other Healthcare Professional
