<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-397
Date of Submission: 2025-02-04

This report was submitted by a Physician from Davis, Martinez and Conner Medical Center concerning patient ANON-PX-1090. The subject is a 27-year-old female with a significant medical history including atrial fibrillation, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin (Penicillin antibiotic) administered via the Topical route at a dosage of 442mg, initiated on 2025-01-06 for Bacterial infection with the course ongoing; Warfarin administered via the Oral route at a dosage of 329mg, initiated on 2025-01-06 for Thromboembolism prevention with the course ongoing.

On approximately 2025-01-25, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Pruritus, Diarrhea. The Stevens-Johnson syndrome was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed article and advised worker. The current patient status regarding this symptom is 'Recovering'. The Pruritus was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Diarrhea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 10 was calculated, The assessment concluded the relationship was 'Highly Probable'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-397
report_date: '2025-02-04'
patient_details:
  patient_id: ANON-PX-1090
  gender: Female
  relevant_history:
  - atrial fibrillation
  - asthma
  age_at_reaction: 27
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 442mg
  route_of_administration: Topical
  start_date: '2025-01-06'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
- drug_name: Warfarin
  dosage: 329mg
  route_of_administration: Oral
  start_date: '2025-01-06'
  indication_for_use: Thromboembolism prevention
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2025-01-25'
  severity: Severe
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed article and advised worker.
- symptom_name: Pruritus
  onset_date: '2025-01-25'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2025-01-25'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Highly Probable
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 10
reporting_facility: Davis, Martinez and Conner Medical Center
reporter_type: Physician
