<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-799
Date of Submission: 2024-11-18

This report was submitted by a Other Healthcare Professional from Peterson LLC Medical Center concerning patient ANON-PX-1927. The subject is a 70-year-old female with a significant medical history including atrial fibrillation, type 2 diabetes. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Intravenous route at a dosage of 362mg, initiated on 2024-09-10 for Hypertension and discontinued on 2024-11-08.

On approximately 2024-11-05, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Anaphylaxis, Hepatotoxicity. The Anaphylaxis was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Hepatotoxicity was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: College must stuff charge report couple begin feeling. Value here a modern role guess.</data>
report_id: ADR-2024-799
report_date: '2024-11-18'
patient_details:
  patient_id: ANON-PX-1927
  gender: Female
  relevant_history:
  - atrial fibrillation
  - type 2 diabetes
  age_at_reaction: 70
suspected_drugs:
- drug_name: Lisinopril
  dosage: 362mg
  route_of_administration: Intravenous
  start_date: '2024-09-10'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2024-11-08'
adverse_reactions:
- symptom_name: Anaphylaxis
  onset_date: '2024-11-05'
  severity: Severe
  outcome: Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-11-05'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Peterson LLC Medical Center
reporter_type: Other Healthcare Professional
notes: College must stuff charge report couple begin feeling. Value here a modern
  role guess.
