<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-849
Date of Submission: 2025-03-07

This report was submitted by a Patient from Hurley-Hernandez Medical Center concerning patient ANON-PX-2631. The subject is an adult male with a significant medical history including osteoarthritis, seasonal allergies, coronary artery disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Omeprazole administered via the Subcutaneous route at a dosage of 188mg, initiated on 2025-01-30 for Gastroesophageal reflux disease and discontinued on 2025-02-15; Lisinopril (ACE inhibitor) administered via the Subcutaneous route at a dosage of 417mg, initiated on 2025-01-30 for Hypertension and discontinued on 2025-02-15.

On approximately 2025-02-14, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Pruritus, Hepatotoxicity. The Pruritus was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Hepatotoxicity was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 6 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Ago full senior notice would newspaper. Unit popular know design.</data>
report_id: ADR-2025-849
report_date: '2025-03-07'
patient_details:
  patient_id: ANON-PX-2631
  gender: Male
  relevant_history:
  - osteoarthritis
  - seasonal allergies
  - coronary artery disease
suspected_drugs:
- drug_name: Omeprazole
  dosage: 188mg
  route_of_administration: Subcutaneous
  start_date: '2025-01-30'
  indication_for_use: Gastroesophageal reflux disease
  end_date: '2025-02-15'
- drug_name: Lisinopril
  dosage: 417mg
  route_of_administration: Subcutaneous
  start_date: '2025-01-30'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2025-02-15'
adverse_reactions:
- symptom_name: Pruritus
  onset_date: '2025-02-14'
  severity: Moderate
  outcome: Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2025-02-14'
  severity: Moderate
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
  naranjo_score: 6
reporting_facility: Hurley-Hernandez Medical Center
reporter_type: Patient
notes: Ago full senior notice would newspaper. Unit popular know design.
