<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-559
Date of Submission: 2024-10-23

This report was submitted by a Pharmacist from Middleton-Shelton Medical Center concerning patient ANON-PX-2427. The subject is an adult male with a significant medical history including migraines, anxiety, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin (Penicillin antibiotic) administered via the Intravenous route at a dosage of 78mg, initiated on 2024-10-05 for Bacterial infection and discontinued on 2024-10-21.

On approximately 2024-10-09, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Hepatotoxicity, Maculopapular Rash, Diarrhea. The Stevens-Johnson syndrome was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Hepatotoxicity was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Maculopapular Rash was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Diarrhea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 5 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Itself position agreement hotel. Degree prove never before. Practice realize five watch whether.</data>
report_id: ADR-2024-559
report_date: '2024-10-23'
patient_details:
  patient_id: ANON-PX-2427
  gender: Male
  relevant_history:
  - migraines
  - anxiety
  - asthma
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 78mg
  route_of_administration: Intravenous
  start_date: '2024-10-05'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
  end_date: '2024-10-21'
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-10-09'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-10-09'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
- symptom_name: Maculopapular Rash
  onset_date: '2024-10-09'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2024-10-09'
  severity: Moderate
  outcome: Fatal
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 5
reporting_facility: Middleton-Shelton Medical Center
reporter_type: Pharmacist
notes: Itself position agreement hotel. Degree prove never before. Practice realize
  five watch whether.
