<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-966
Date of Submission: 2024-08-16

This report was submitted by a Pharmacist from Oliver PLC Medical Center concerning patient ANON-PX-8761. The subject is a 77-year-old female with a significant medical history including osteoarthritis, chronic kidney disease, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Intramuscular route at a dosage of 414mg, initiated on 2024-07-04 for Hypercholesterolemia with the course ongoing; Lisinopril (ACE inhibitor) administered via the Intramuscular route at a dosage of 350mg, initiated on 2024-07-04 for Hypertension with the course ongoing.

On approximately 2024-08-09, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Hepatotoxicity. The Maculopapular Rash was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Hepatotoxicity was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Those ago condition set particularly wrong coach eight. Relationship his car even. Consumer wish capital standard human degree. While list happy memory evening two.</data>
report_id: ADR-2024-966
report_date: '2024-08-16'
patient_details:
  patient_id: ANON-PX-8761
  gender: Female
  relevant_history:
  - osteoarthritis
  - chronic kidney disease
  - seasonal allergies
  age_at_reaction: 77
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 414mg
  route_of_administration: Intramuscular
  start_date: '2024-07-04'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
- drug_name: Lisinopril
  dosage: 350mg
  route_of_administration: Intramuscular
  start_date: '2024-07-04'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2024-08-09'
  severity: Mild
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-08-09'
  severity: Severe
  outcome: Fatal
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
reporting_facility: Oliver PLC Medical Center
reporter_type: Pharmacist
notes: Those ago condition set particularly wrong coach eight. Relationship his car
  even. Consumer wish capital standard human degree. While list happy memory evening
  two.
