<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-785
Date of Submission: 2025-04-12

This report was submitted by a Other Healthcare Professional from Martinez LLC Medical Center concerning patient ANON-PX-7513. The subject is a 74-year-old male with a significant medical history including asthma, coronary artery disease, seasonal allergies, osteoarthritis. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Sertraline (SSRI) administered via the Topical route at a dosage of 442mg, initiated on 2025-04-01 for Major depressive disorder and discontinued on 2025-04-09.

On approximately 2025-04-08, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Nausea, Hepatotoxicity, Pruritus, Dizziness, Anaphylaxis. The Nausea was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Hepatotoxicity was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Pruritus was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed race and advised among. The current patient status regarding this symptom is 'Fatal'. The Dizziness was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed author and advised detail. The current patient status regarding this symptom is 'Recovered'. The Anaphylaxis was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Kind recently figure. Body culture record hear fire subject.</data>
report_id: ADR-2025-785
report_date: '2025-04-12'
patient_details:
  patient_id: ANON-PX-7513
  gender: Male
  relevant_history:
  - asthma
  - coronary artery disease
  - seasonal allergies
  - osteoarthritis
  age_at_reaction: 74
suspected_drugs:
- drug_name: Sertraline
  dosage: 442mg
  route_of_administration: Topical
  start_date: '2025-04-01'
  indication_for_use: Major depressive disorder
  drug_class: SSRI
  end_date: '2025-04-09'
adverse_reactions:
- symptom_name: Nausea
  onset_date: '2025-04-08'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
- symptom_name: Hepatotoxicity
  onset_date: '2025-04-08'
  severity: Mild
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2025-04-08'
  severity: Moderate
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed race and advised among.
- symptom_name: Dizziness
  onset_date: '2025-04-08'
  severity: Severe
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed author and advised detail.
- symptom_name: Anaphylaxis
  onset_date: '2025-04-08'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Martinez LLC Medical Center
reporter_type: Other Healthcare Professional
notes: Kind recently figure. Body culture record hear fire subject.
