<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-316
Date of Submission: 2024-09-08

This report was submitted by a Other Healthcare Professional from Allen and Sons Medical Center concerning patient ANON-PX-4672. The subject is a 68-year-old other with a significant medical history including migraines, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Warfarin (Anticoagulant) administered via the Subcutaneous route at a dosage of 297mg, initiated on 2024-06-14 for Thromboembolism prevention and discontinued on 2024-09-05; Atorvastatin (Statin) administered via the Intravenous route at a dosage of 444mg, initiated on 2024-06-14 for Hypercholesterolemia and discontinued on 2024-09-05.

On approximately 2024-08-22, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Somnolence, Anaphylaxis, Nausea. The Hepatotoxicity was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed science and advised job. The current patient status regarding this symptom is 'Unknown'. The Somnolence was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed put and advised also. The current patient status regarding this symptom is 'Recovering'. The Anaphylaxis was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Nausea was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 5 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Share song beat sell large nor. Me feel office head soon sit arm. Pick hope far measure someone must.</data>
report_id: ADR-2024-316
report_date: '2024-09-08'
patient_details:
  patient_id: ANON-PX-4672
  gender: Other
  relevant_history:
  - migraines
  - asthma
  age_at_reaction: 68
suspected_drugs:
- drug_name: Warfarin
  dosage: 297mg
  route_of_administration: Subcutaneous
  start_date: '2024-06-14'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
  end_date: '2024-09-05'
- drug_name: Atorvastatin
  dosage: 444mg
  route_of_administration: Intravenous
  start_date: '2024-06-14'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
  end_date: '2024-09-05'
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2024-08-22'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed science and advised job.
- symptom_name: Somnolence
  onset_date: '2024-08-22'
  severity: Severe
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed put and advised also.
- symptom_name: Anaphylaxis
  onset_date: '2024-08-22'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
- symptom_name: Nausea
  onset_date: '2024-08-22'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 5
reporting_facility: Allen and Sons Medical Center
reporter_type: Other Healthcare Professional
notes: Share song beat sell large nor. Me feel office head soon sit arm. Pick hope
  far measure someone must.
