<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-791
Date of Submission: 2024-11-24

This report was submitted by a Other Healthcare Professional from Murphy LLC Medical Center concerning patient ANON-PX-7559. The subject is a 22-year-old female with a significant medical history including osteoarthritis, atrial fibrillation, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Levothyroxine (Thyroid hormone) administered via the Intravenous route at a dosage of 6mg, initiated on 2024-10-08 for Hypothyroidism with the course ongoing.

On approximately 2024-11-22, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Hepatotoxicity, Headache, Anaphylaxis. The Stevens-Johnson syndrome was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Hepatotoxicity was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Headache was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Anaphylaxis was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed step and advised list. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-791
report_date: '2024-11-24'
patient_details:
  patient_id: ANON-PX-7559
  gender: Female
  relevant_history:
  - osteoarthritis
  - atrial fibrillation
  - seasonal allergies
  age_at_reaction: 22
suspected_drugs:
- drug_name: Levothyroxine
  dosage: 6mg
  route_of_administration: Intravenous
  start_date: '2024-10-08'
  indication_for_use: Hypothyroidism
  drug_class: Thyroid hormone
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-11-22'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-11-22'
  severity: Mild
  outcome: Fatal
  intervention_required: false
- symptom_name: Headache
  onset_date: '2024-11-22'
  severity: Severe
  outcome: Recovering
  intervention_required: false
- symptom_name: Anaphylaxis
  onset_date: '2024-11-22'
  severity: Severe
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed step and advised list.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Murphy LLC Medical Center
reporter_type: Other Healthcare Professional
