<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-609
Date of Submission: 2024-10-31

This report was submitted by a Patient from Page Group Medical Center concerning patient ANON-PX-1233. The subject is an adult other with a significant medical history including migraines, asthma, osteoarthritis. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Oral route at a dosage of 415mg, initiated on 2024-10-20 for Pain and inflammation and discontinued on 2024-10-23.

On approximately 2024-10-22, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Pruritus. The Angioedema was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed despite and advised require. The current patient status regarding this symptom is 'Recovered'. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 10 was calculated, The assessment concluded the relationship was 'Highly Probable'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Rest unit the vote expert oil lose. Heart meeting care soldier also.</data>
report_id: ADR-2024-609
report_date: '2024-10-31'
patient_details:
  patient_id: ANON-PX-1233
  gender: Other
  relevant_history:
  - migraines
  - asthma
  - osteoarthritis
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 415mg
  route_of_administration: Oral
  start_date: '2024-10-20'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-10-23'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2024-10-22'
  severity: Severe
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed despite and advised require.
- symptom_name: Pruritus
  onset_date: '2024-10-22'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
causality_assessment:
  assessment_conclusion: Highly Probable
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 10
reporting_facility: Page Group Medical Center
reporter_type: Patient
notes: Rest unit the vote expert oil lose. Heart meeting care soldier also.
