<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-149
Date of Submission: 2025-02-24

This report was submitted by a Other Healthcare Professional from Petersen, Wilson and Frazier Medical Center concerning patient ANON-PX-2592. The subject is a 33-year-old male with a significant medical history including hypertension, type 2 diabetes, coronary artery disease, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin (Penicillin antibiotic) administered via the Topical route at a dosage of 134mg, initiated on 2025-01-07 for Bacterial infection and discontinued on 2025-02-12; Ibuprofen (NSAID) administered via the Topical route at a dosage of 339mg, initiated on 2025-01-07 for Pain and inflammation and discontinued on 2025-02-12.

On approximately 2025-01-10, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Somnolence, Nausea. The Somnolence was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Nausea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Particularly whose whether spend instead candidate. Instead agent mission him. White food stay cultural the the.</data>
report_id: ADR-2025-149
report_date: '2025-02-24'
patient_details:
  patient_id: ANON-PX-2592
  gender: Male
  relevant_history:
  - hypertension
  - type 2 diabetes
  - coronary artery disease
  - atrial fibrillation
  age_at_reaction: 33
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 134mg
  route_of_administration: Topical
  start_date: '2025-01-07'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
  end_date: '2025-02-12'
- drug_name: Ibuprofen
  dosage: 339mg
  route_of_administration: Topical
  start_date: '2025-01-07'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2025-02-12'
adverse_reactions:
- symptom_name: Somnolence
  onset_date: '2025-01-10'
  severity: Severe
  outcome: Fatal
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2025-01-10'
  severity: Moderate
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
reporting_facility: Petersen, Wilson and Frazier Medical Center
reporter_type: Other Healthcare Professional
notes: Particularly whose whether spend instead candidate. Instead agent mission him.
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