<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-250
Date of Submission: 2024-09-09

This report was submitted by a Patient from Miller-Sparks Medical Center concerning patient ANON-PX-3702. The subject is a 52-year-old female with a significant medical history including hypertension, asthma, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Topical route at a dosage of 21mg, initiated on 2024-07-04 for Hypercholesterolemia with the course ongoing; Levothyroxine (Thyroid hormone) administered via the Oral route at a dosage of 348mg, initiated on 2024-07-04 for Hypothyroidism with the course ongoing.

On approximately 2024-07-15, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Anaphylaxis, Pruritus, Diarrhea, Dizziness. The Anaphylaxis was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Pruritus was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Diarrhea was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Dizziness was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 5 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

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report_id: ADR-2024-250
report_date: '2024-09-09'
patient_details:
  patient_id: ANON-PX-3702
  gender: Female
  relevant_history:
  - hypertension
  - asthma
  - atrial fibrillation
  age_at_reaction: 52
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 21mg
  route_of_administration: Topical
  start_date: '2024-07-04'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
- drug_name: Levothyroxine
  dosage: 348mg
  route_of_administration: Oral
  start_date: '2024-07-04'
  indication_for_use: Hypothyroidism
  drug_class: Thyroid hormone
adverse_reactions:
- symptom_name: Anaphylaxis
  onset_date: '2024-07-15'
  severity: Severe
  outcome: Recovered
  intervention_required: true
- symptom_name: Pruritus
  onset_date: '2024-07-15'
  severity: Severe
  outcome: Recovering
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2024-07-15'
  severity: Severe
  outcome: Unknown
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2024-07-15'
  severity: Severe
  outcome: Recovering
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 5
reporting_facility: Miller-Sparks Medical Center
reporter_type: Patient
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