<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-529
Date of Submission: 2025-02-09

This report was submitted by a Pharmacist from Edwards LLC Medical Center concerning patient ANON-PX-8299. The subject is an adult other with a significant medical history including migraines, type 2 diabetes. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Subcutaneous route at a dosage of 496mg, initiated on 2024-11-13 for Hypertension and discontinued on 2025-01-29.

On approximately 2025-01-28, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Somnolence, Anaphylaxis, Headache, Stevens-Johnson syndrome, Diarrhea. The Somnolence was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Anaphylaxis was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed dream and advised movie. The current patient status regarding this symptom is 'Not Recovered'. The Headache was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Stevens-Johnson syndrome was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed minute and advised black. The current patient status regarding this symptom is 'Fatal'. The Diarrhea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-529
report_date: '2025-02-09'
patient_details:
  patient_id: ANON-PX-8299
  gender: Other
  relevant_history:
  - migraines
  - type 2 diabetes
suspected_drugs:
- drug_name: Lisinopril
  dosage: 496mg
  route_of_administration: Subcutaneous
  start_date: '2024-11-13'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2025-01-29'
adverse_reactions:
- symptom_name: Somnolence
  onset_date: '2025-01-28'
  severity: Severe
  outcome: Fatal
  intervention_required: false
- symptom_name: Anaphylaxis
  onset_date: '2025-01-28'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed dream and advised movie.
- symptom_name: Headache
  onset_date: '2025-01-28'
  severity: Mild
  outcome: Fatal
  intervention_required: false
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2025-01-28'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed minute and advised black.
- symptom_name: Diarrhea
  onset_date: '2025-01-28'
  severity: Moderate
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
reporting_facility: Edwards LLC Medical Center
reporter_type: Pharmacist
