<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-318
Date of Submission: 2025-02-24

This report was submitted by a Physician from Curry, Lucas and Jones Medical Center concerning patient ANON-PX-8658. The subject is a 76-year-old female with a significant medical history including coronary artery disease, migraines, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin (Penicillin antibiotic) administered via the Topical route at a dosage of 147mg, initiated on 2025-01-08 for Bacterial infection and discontinued on 2025-02-11.

On approximately 2025-01-29, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Nausea, Anaphylaxis, Vomiting, Headache. The Maculopapular Rash was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Nausea was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed fear and advised whom. The current patient status regarding this symptom is 'Recovered'. The Anaphylaxis was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Vomiting was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed item and advised nice. The current patient status regarding this symptom is 'Recovered'. The Headache was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-318
report_date: '2025-02-24'
patient_details:
  patient_id: ANON-PX-8658
  gender: Female
  relevant_history:
  - coronary artery disease
  - migraines
  - seasonal allergies
  age_at_reaction: 76
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 147mg
  route_of_administration: Topical
  start_date: '2025-01-08'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
  end_date: '2025-02-11'
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2025-01-29'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2025-01-29'
  severity: Severe
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed fear and advised whom.
- symptom_name: Anaphylaxis
  onset_date: '2025-01-29'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2025-01-29'
  severity: Mild
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed item and advised nice.
- symptom_name: Headache
  onset_date: '2025-01-29'
  severity: Severe
  outcome: Fatal
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
reporting_facility: Curry, Lucas and Jones Medical Center
reporter_type: Physician
