<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-721
Date of Submission: 2024-10-25

This report was submitted by a Patient from Patterson-Rogers Medical Center concerning patient ANON-PX-9754. The subject is a 37-year-old male with a significant medical history including atrial fibrillation, hypertension. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin administered via the Topical route at a dosage of 495mg, initiated on 2024-07-28 for Hypercholesterolemia with the course ongoing; Warfarin (Anticoagulant) administered via the Intravenous route at a dosage of 117mg, initiated on 2024-07-28 for Thromboembolism prevention with the course ongoing.

On approximately 2024-09-02, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Headache, Hepatotoxicity, Vomiting, Pruritus, Angioedema. The Headache was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Hepatotoxicity was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Vomiting was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Pruritus was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed artist and advised administration. The current patient status regarding this symptom is 'Unknown'. The Angioedema was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Only grow bank. Move pass inside sit. American provide strategy job.</data>
report_id: ADR-2024-721
report_date: '2024-10-25'
patient_details:
  patient_id: ANON-PX-9754
  gender: Male
  relevant_history:
  - atrial fibrillation
  - hypertension
  age_at_reaction: 37
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 495mg
  route_of_administration: Topical
  start_date: '2024-07-28'
  indication_for_use: Hypercholesterolemia
- drug_name: Warfarin
  dosage: 117mg
  route_of_administration: Intravenous
  start_date: '2024-07-28'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
adverse_reactions:
- symptom_name: Headache
  onset_date: '2024-09-02'
  severity: Severe
  outcome: Fatal
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-09-02'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2024-09-02'
  severity: Mild
  outcome: Fatal
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2024-09-02'
  severity: Mild
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed artist and advised administration.
- symptom_name: Angioedema
  onset_date: '2024-09-02'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Patterson-Rogers Medical Center
reporter_type: Patient
notes: Only grow bank. Move pass inside sit. American provide strategy job.
