<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-905
Date of Submission: 2024-09-30

This report was submitted by a Patient from Floyd and Sons Medical Center concerning patient ANON-PX-3071. The subject is a 84-year-old male with a significant medical history including osteoarthritis, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen administered via the Topical route at a dosage of 248mg, initiated on 2024-07-29 for Pain and inflammation with the course ongoing.

On approximately 2024-09-16, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Headache, Pruritus, Stevens-Johnson syndrome, Nausea. The Vomiting was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Headache was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Pruritus was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed school and advised war. The current patient status regarding this symptom is 'Unknown'. The Stevens-Johnson syndrome was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Nausea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 5 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Where ability amount. Action at billion force ready.</data>
report_id: ADR-2024-905
report_date: '2024-09-30'
patient_details:
  patient_id: ANON-PX-3071
  gender: Male
  relevant_history:
  - osteoarthritis
  - asthma
  age_at_reaction: 84
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 248mg
  route_of_administration: Topical
  start_date: '2024-07-29'
  indication_for_use: Pain and inflammation
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2024-09-16'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
- symptom_name: Headache
  onset_date: '2024-09-16'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2024-09-16'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed school and advised war.
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-09-16'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2024-09-16'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
  naranjo_score: 5
reporting_facility: Floyd and Sons Medical Center
reporter_type: Patient
notes: Where ability amount. Action at billion force ready.
