<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-906
Date of Submission: 2024-10-08

This report was submitted by a Other Healthcare Professional from Kelly, Zamora and Thornton Medical Center concerning patient ANON-PX-2563. The subject is a 65-year-old female with a significant medical history including migraines, anxiety. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Warfarin (Anticoagulant) administered via the Topical route at a dosage of 168mg, initiated on 2024-09-27 for Thromboembolism prevention with the course ongoing.

On approximately 2024-10-06, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Nausea, Somnolence, Stevens-Johnson syndrome, Maculopapular Rash, Diarrhea. The Nausea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Somnolence was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed huge and advised perhaps. The current patient status regarding this symptom is 'Recovering'. The Stevens-Johnson syndrome was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed tonight and advised I. The current patient status regarding this symptom is 'Not Recovered'. The Maculopapular Rash was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Diarrhea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 2 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Our who ask success term.</data>
report_id: ADR-2024-906
report_date: '2024-10-08'
patient_details:
  patient_id: ANON-PX-2563
  gender: Female
  relevant_history:
  - migraines
  - anxiety
  age_at_reaction: 65
suspected_drugs:
- drug_name: Warfarin
  dosage: 168mg
  route_of_administration: Topical
  start_date: '2024-09-27'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
adverse_reactions:
- symptom_name: Nausea
  onset_date: '2024-10-06'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Somnolence
  onset_date: '2024-10-06'
  severity: Moderate
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed huge and advised perhaps.
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-10-06'
  severity: Severe
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed tonight and advised I.
- symptom_name: Maculopapular Rash
  onset_date: '2024-10-06'
  severity: Mild
  outcome: Fatal
  intervention_required: false
- symptom_name: Diarrhea
  onset_date: '2024-10-06'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 2
reporting_facility: Kelly, Zamora and Thornton Medical Center
reporter_type: Other Healthcare Professional
notes: Our who ask success term.
