<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-793
Date of Submission: 2024-10-29

This report was submitted by a Physician from Duffy Group Medical Center concerning patient ANON-PX-7174. The subject is a 40-year-old other with a significant medical history including hypertension, chronic kidney disease, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Levothyroxine (Thyroid hormone) administered via the Subcutaneous route at a dosage of 158mg, initiated on 2024-10-13 for Hypothyroidism with the course ongoing; Amoxicillin (Penicillin antibiotic) administered via the Intravenous route at a dosage of 55mg, initiated on 2024-10-13 for Bacterial infection with the course ongoing.

On approximately 2024-10-17, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Dizziness, Headache, Stevens-Johnson syndrome, Maculopapular Rash. The Dizziness was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Headache was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed history and advised challenge. The current patient status regarding this symptom is 'Not Recovered'. The Stevens-Johnson syndrome was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed expert and advised carry. The current patient status regarding this symptom is 'Fatal'. The Maculopapular Rash was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 3 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Assume natural among model. Trip true region newspaper.</data>
report_id: ADR-2024-793
report_date: '2024-10-29'
patient_details:
  patient_id: ANON-PX-7174
  gender: Other
  relevant_history:
  - hypertension
  - chronic kidney disease
  - asthma
  age_at_reaction: 40
suspected_drugs:
- drug_name: Levothyroxine
  dosage: 158mg
  route_of_administration: Subcutaneous
  start_date: '2024-10-13'
  indication_for_use: Hypothyroidism
  drug_class: Thyroid hormone
- drug_name: Amoxicillin
  dosage: 55mg
  route_of_administration: Intravenous
  start_date: '2024-10-13'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
adverse_reactions:
- symptom_name: Dizziness
  onset_date: '2024-10-17'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
- symptom_name: Headache
  onset_date: '2024-10-17'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed history and advised challenge.
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-10-17'
  severity: Mild
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed expert and advised carry.
- symptom_name: Maculopapular Rash
  onset_date: '2024-10-17'
  severity: Moderate
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Positive dechallenge
  naranjo_score: 3
reporting_facility: Duffy Group Medical Center
reporter_type: Physician
notes: Assume natural among model. Trip true region newspaper.
