<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-651
Date of Submission: 2024-08-16

This report was submitted by a Other Healthcare Professional from Ramirez PLC Medical Center concerning patient ANON-PX-5537. The subject is a 83-year-old female with a significant medical history including seasonal allergies, anxiety, type 2 diabetes. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen administered via the Intravenous route at a dosage of 287mg, initiated on 2024-06-18 for Pain and inflammation and discontinued on 2024-08-11.

On approximately 2024-08-02, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Nausea, Stevens-Johnson syndrome, Pruritus. The Hepatotoxicity was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed interview and advised serve. The current patient status regarding this symptom is 'Unknown'. The Nausea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Stevens-Johnson syndrome was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed weight and advised enough. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 2 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: All project strong administration spend. Nothing tough let prepare.</data>
report_id: ADR-2024-651
report_date: '2024-08-16'
patient_details:
  patient_id: ANON-PX-5537
  gender: Female
  relevant_history:
  - seasonal allergies
  - anxiety
  - type 2 diabetes
  age_at_reaction: 83
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 287mg
  route_of_administration: Intravenous
  start_date: '2024-06-18'
  indication_for_use: Pain and inflammation
  end_date: '2024-08-11'
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2024-08-02'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed interview and advised serve.
- symptom_name: Nausea
  onset_date: '2024-08-02'
  severity: Moderate
  outcome: Recovered
  intervention_required: false
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-08-02'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2024-08-02'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed weight and advised enough.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 2
reporting_facility: Ramirez PLC Medical Center
reporter_type: Other Healthcare Professional
notes: All project strong administration spend. Nothing tough let prepare.
