<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-887
Date of Submission: 2024-09-14

This report was submitted by a Other Healthcare Professional from Lewis, Arroyo and Wheeler Medical Center concerning patient ANON-PX-5524. The subject is a 18-year-old other with a significant medical history including type 2 diabetes, atrial fibrillation, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin administered via the Intravenous route at a dosage of 39mg, initiated on 2024-07-29 for Bacterial infection and discontinued on 2024-09-07; Ibuprofen (NSAID) administered via the Intramuscular route at a dosage of 477mg, initiated on 2024-07-29 for Pain and inflammation and discontinued on 2024-09-07.

On approximately 2024-08-06, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Diarrhea, Pruritus, Maculopapular Rash, Somnolence, Dizziness. The Diarrhea was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Fatal'. The Pruritus was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Maculopapular Rash was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed common and advised million. The current patient status regarding this symptom is 'Unknown'. The Somnolence was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Dizziness was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 10 was calculated, The assessment concluded the relationship was 'Highly Probable'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

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report_id: ADR-2024-887
report_date: '2024-09-14'
patient_details:
  patient_id: ANON-PX-5524
  gender: Other
  relevant_history:
  - type 2 diabetes
  - atrial fibrillation
  - asthma
  age_at_reaction: 18
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 39mg
  route_of_administration: Intravenous
  start_date: '2024-07-29'
  indication_for_use: Bacterial infection
  end_date: '2024-09-07'
- drug_name: Ibuprofen
  dosage: 477mg
  route_of_administration: Intramuscular
  start_date: '2024-07-29'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-09-07'
adverse_reactions:
- symptom_name: Diarrhea
  onset_date: '2024-08-06'
  severity: Moderate
  outcome: Fatal
  intervention_required: true
- symptom_name: Pruritus
  onset_date: '2024-08-06'
  severity: Severe
  outcome: Fatal
  intervention_required: false
- symptom_name: Maculopapular Rash
  onset_date: '2024-08-06'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed common and advised million.
- symptom_name: Somnolence
  onset_date: '2024-08-06'
  severity: Mild
  outcome: Unknown
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2024-08-06'
  severity: Mild
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Highly Probable
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 10
reporting_facility: Lewis, Arroyo and Wheeler Medical Center
reporter_type: Other Healthcare Professional
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