<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-374
Date of Submission: 2024-08-23

This report was submitted by a Other Healthcare Professional from Washington-Berry Medical Center concerning patient ANON-PX-8761. The subject is a 50-year-old other with a significant medical history including type 2 diabetes, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Intramuscular route at a dosage of 108mg, initiated on 2024-07-27 for Hypertension and discontinued on 2024-08-18; Amoxicillin (Penicillin antibiotic) administered via the Intramuscular route at a dosage of 395mg, initiated on 2024-07-27 for Bacterial infection and discontinued on 2024-08-18.

On approximately 2024-08-12, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Hepatotoxicity, Maculopapular Rash, Somnolence. The Stevens-Johnson syndrome was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Hepatotoxicity was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Maculopapular Rash was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Somnolence was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed many and advised back. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 3 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Heart major maintain level someone between west provide. Enter rock effect weight little than into. Subject part clearly expect employee them.</data>
report_id: ADR-2024-374
report_date: '2024-08-23'
patient_details:
  patient_id: ANON-PX-8761
  gender: Other
  relevant_history:
  - type 2 diabetes
  - seasonal allergies
  age_at_reaction: 50
suspected_drugs:
- drug_name: Lisinopril
  dosage: 108mg
  route_of_administration: Intramuscular
  start_date: '2024-07-27'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2024-08-18'
- drug_name: Amoxicillin
  dosage: 395mg
  route_of_administration: Intramuscular
  start_date: '2024-07-27'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
  end_date: '2024-08-18'
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-08-12'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-08-12'
  severity: Severe
  outcome: Unknown
  intervention_required: false
- symptom_name: Maculopapular Rash
  onset_date: '2024-08-12'
  severity: Severe
  outcome: Recovered
  intervention_required: false
- symptom_name: Somnolence
  onset_date: '2024-08-12'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed many and advised back.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Positive dechallenge
  naranjo_score: 3
reporting_facility: Washington-Berry Medical Center
reporter_type: Other Healthcare Professional
notes: Heart major maintain level someone between west provide. Enter rock effect
  weight little than into. Subject part clearly expect employee them.
