<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-721
Date of Submission: 2025-05-03

This report was submitted by a Physician from Thompson PLC Medical Center concerning patient ANON-PX-6408. The subject is a 54-year-old other with a significant medical history including osteoarthritis, coronary artery disease, chronic kidney disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Levothyroxine administered via the Intravenous route at a dosage of 87mg, initiated on 2025-02-05 for Hypothyroidism with the course ongoing.

On approximately 2025-02-18, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Dizziness, Headache, Vomiting. The Stevens-Johnson syndrome was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Dizziness was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Headache was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Vomiting was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-721
report_date: '2025-05-03'
patient_details:
  patient_id: ANON-PX-6408
  gender: Other
  relevant_history:
  - osteoarthritis
  - coronary artery disease
  - chronic kidney disease
  age_at_reaction: 54
suspected_drugs:
- drug_name: Levothyroxine
  dosage: 87mg
  route_of_administration: Intravenous
  start_date: '2025-02-05'
  indication_for_use: Hypothyroidism
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2025-02-18'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
- symptom_name: Dizziness
  onset_date: '2025-02-18'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
- symptom_name: Headache
  onset_date: '2025-02-18'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
- symptom_name: Vomiting
  onset_date: '2025-02-18'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
reporting_facility: Thompson PLC Medical Center
reporter_type: Physician
