<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-663
Date of Submission: 2025-02-10

This report was submitted by a Other Healthcare Professional from Cameron, Orr and Oliver Medical Center concerning patient ANON-PX-1323. The subject is a 50-year-old female with a significant medical history including atrial fibrillation, type 2 diabetes, seasonal allergies, anxiety. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Levothyroxine (Thyroid hormone) administered via the Topical route at a dosage of 464mg, initiated on 2024-12-04 for Hypothyroidism and discontinued on 2025-01-26.

On approximately 2025-01-17, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Pruritus. The Maculopapular Rash was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Pruritus was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Everything total tend military. Interesting place sit degree magazine term bad. Against event scientist media I agreement.</data>
report_id: ADR-2025-663
report_date: '2025-02-10'
patient_details:
  patient_id: ANON-PX-1323
  gender: Female
  relevant_history:
  - atrial fibrillation
  - type 2 diabetes
  - seasonal allergies
  - anxiety
  age_at_reaction: 50
suspected_drugs:
- drug_name: Levothyroxine
  dosage: 464mg
  route_of_administration: Topical
  start_date: '2024-12-04'
  indication_for_use: Hypothyroidism
  drug_class: Thyroid hormone
  end_date: '2025-01-26'
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2025-01-17'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Pruritus
  onset_date: '2025-01-17'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
reporting_facility: Cameron, Orr and Oliver Medical Center
reporter_type: Other Healthcare Professional
notes: Everything total tend military. Interesting place sit degree magazine term
  bad. Against event scientist media I agreement.
