<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-843
Date of Submission: 2024-11-17

This report was submitted by a Nurse from Watts-Mclaughlin Medical Center concerning patient ANON-PX-4040. The subject is a 43-year-old female with a significant medical history including osteoarthritis, chronic kidney disease, hypertension. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Amoxicillin administered via the Topical route at a dosage of 229mg, initiated on 2024-10-30 for Bacterial infection and discontinued on 2024-11-15.

On approximately 2024-11-08, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Headache, Nausea, Vomiting, Somnolence, Maculopapular Rash. The Headache was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Nausea was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed approach and advised happy. The current patient status regarding this symptom is 'Unknown'. The Vomiting was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Somnolence was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Maculopapular Rash was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 5 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: We business choose behind recent. Discover thousand media challenge. World none keep couple fact.</data>
report_id: ADR-2024-843
report_date: '2024-11-17'
patient_details:
  patient_id: ANON-PX-4040
  gender: Female
  relevant_history:
  - osteoarthritis
  - chronic kidney disease
  - hypertension
  age_at_reaction: 43
suspected_drugs:
- drug_name: Amoxicillin
  dosage: 229mg
  route_of_administration: Topical
  start_date: '2024-10-30'
  indication_for_use: Bacterial infection
  end_date: '2024-11-15'
adverse_reactions:
- symptom_name: Headache
  onset_date: '2024-11-08'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2024-11-08'
  severity: Mild
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed approach and advised happy.
- symptom_name: Vomiting
  onset_date: '2024-11-08'
  severity: Severe
  outcome: Recovering
  intervention_required: true
- symptom_name: Somnolence
  onset_date: '2024-11-08'
  severity: Severe
  outcome: Recovered
  intervention_required: false
- symptom_name: Maculopapular Rash
  onset_date: '2024-11-08'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 5
reporting_facility: Watts-Mclaughlin Medical Center
reporter_type: Nurse
notes: We business choose behind recent. Discover thousand media challenge. World
  none keep couple fact.
