<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-117
Date of Submission: 2024-08-31

This report was submitted by a Nurse from Juarez PLC Medical Center concerning patient ANON-PX-7112. The subject is a 83-year-old male with a significant medical history including osteoarthritis, coronary artery disease, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin administered via the Topical route at a dosage of 204mg, initiated on 2024-06-08 for Hypercholesterolemia and discontinued on 2024-08-26; Sertraline (SSRI) administered via the Subcutaneous route at a dosage of 51mg, initiated on 2024-06-08 for Major depressive disorder and discontinued on 2024-08-26.

On approximately 2024-08-13, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Diarrhea, Angioedema. The Diarrhea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Angioedema was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 8 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Ok public state way. Accept hotel reach deal go. Election toward receive decide month former think.</data>
report_id: ADR-2024-117
report_date: '2024-08-31'
patient_details:
  patient_id: ANON-PX-7112
  gender: Male
  relevant_history:
  - osteoarthritis
  - coronary artery disease
  - atrial fibrillation
  age_at_reaction: 83
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 204mg
  route_of_administration: Topical
  start_date: '2024-06-08'
  indication_for_use: Hypercholesterolemia
  end_date: '2024-08-26'
- drug_name: Sertraline
  dosage: 51mg
  route_of_administration: Subcutaneous
  start_date: '2024-06-08'
  indication_for_use: Major depressive disorder
  drug_class: SSRI
  end_date: '2024-08-26'
adverse_reactions:
- symptom_name: Diarrhea
  onset_date: '2024-08-13'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
- symptom_name: Angioedema
  onset_date: '2024-08-13'
  severity: Mild
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 8
reporting_facility: Juarez PLC Medical Center
reporter_type: Nurse
notes: Ok public state way. Accept hotel reach deal go. Election toward receive decide
  month former think.
