<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-886
Date of Submission: 2024-12-27

This report was submitted by a Other Healthcare Professional from Harris PLC Medical Center concerning patient ANON-PX-9432. The subject is an adult female with a significant medical history including seasonal allergies, osteoarthritis, chronic kidney disease, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Subcutaneous route at a dosage of 118mg, initiated on 2024-11-05 for Hypertension and discontinued on 2024-12-03.

On approximately 2024-11-18, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Pruritus, Nausea, Vomiting, Anaphylaxis. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed firm and advised population. The current patient status regarding this symptom is 'Fatal'. The Nausea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Vomiting was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed position and advised else. The current patient status regarding this symptom is 'Unknown'. The Anaphylaxis was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Instead child ahead at shake direction tell side. President see no front program part push relationship. Continue job how ago successful animal.</data>
report_id: ADR-2024-886
report_date: '2024-12-27'
patient_details:
  patient_id: ANON-PX-9432
  gender: Female
  relevant_history:
  - seasonal allergies
  - osteoarthritis
  - chronic kidney disease
  - asthma
suspected_drugs:
- drug_name: Lisinopril
  dosage: 118mg
  route_of_administration: Subcutaneous
  start_date: '2024-11-05'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2024-12-03'
adverse_reactions:
- symptom_name: Pruritus
  onset_date: '2024-11-18'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed firm and advised population.
- symptom_name: Nausea
  onset_date: '2024-11-18'
  severity: Life-threatening
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2024-11-18'
  severity: Mild
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed position and advised else.
- symptom_name: Anaphylaxis
  onset_date: '2024-11-18'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Rechallenge not performed
reporting_facility: Harris PLC Medical Center
reporter_type: Other Healthcare Professional
notes: Instead child ahead at shake direction tell side. President see no front program
  part push relationship. Continue job how ago successful animal.
