<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-485
Date of Submission: 2025-02-24

This report was submitted by a Other Healthcare Professional from Brown, Walker and Mcconnell Medical Center concerning patient ANON-PX-2349. The subject is a 34-year-old male with a significant medical history including asthma, osteoarthritis. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Oral route at a dosage of 416mg, initiated on 2024-12-20 for Hypercholesterolemia and discontinued on 2025-02-19; Sertraline administered via the Oral route at a dosage of 229mg, initiated on 2024-12-20 for Major depressive disorder and discontinued on 2025-02-19.

On approximately 2025-02-15, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Stevens-Johnson syndrome, Nausea, Dizziness. The Angioedema was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Stevens-Johnson syndrome was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Nausea was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Dizziness was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 1 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Tough speech player field. Center role professional strong despite international eight.</data>
report_id: ADR-2025-485
report_date: '2025-02-24'
patient_details:
  patient_id: ANON-PX-2349
  gender: Male
  relevant_history:
  - asthma
  - osteoarthritis
  age_at_reaction: 34
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 416mg
  route_of_administration: Oral
  start_date: '2024-12-20'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
  end_date: '2025-02-19'
- drug_name: Sertraline
  dosage: 229mg
  route_of_administration: Oral
  start_date: '2024-12-20'
  indication_for_use: Major depressive disorder
  end_date: '2025-02-19'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2025-02-15'
  severity: Severe
  outcome: Unknown
  intervention_required: true
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2025-02-15'
  severity: Severe
  outcome: Fatal
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2025-02-15'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
- symptom_name: Dizziness
  onset_date: '2025-02-15'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 1
reporting_facility: Brown, Walker and Mcconnell Medical Center
reporter_type: Other Healthcare Professional
notes: Tough speech player field. Center role professional strong despite international
  eight.
