<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-709
Date of Submission: 2025-04-14

This report was submitted by a Patient from Leblanc LLC Medical Center concerning patient ANON-PX-7354. The subject is a 27-year-old female with a significant medical history including anxiety, migraines. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Subcutaneous route at a dosage of 341mg, initiated on 2025-02-04 for Hypertension and discontinued on 2025-04-10; Levothyroxine administered via the Intravenous route at a dosage of 7mg, initiated on 2025-02-04 for Hypothyroidism and discontinued on 2025-04-10.

On approximately 2025-02-25, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Anaphylaxis, Nausea, Angioedema, Hepatotoxicity. The Anaphylaxis was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Nausea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Angioedema was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed woman and advised by. The current patient status regarding this symptom is 'Recovering'. The Hepatotoxicity was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 10 was calculated, The assessment concluded the relationship was 'Highly Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-709
report_date: '2025-04-14'
patient_details:
  patient_id: ANON-PX-7354
  gender: Female
  relevant_history:
  - anxiety
  - migraines
  age_at_reaction: 27
suspected_drugs:
- drug_name: Lisinopril
  dosage: 341mg
  route_of_administration: Subcutaneous
  start_date: '2025-02-04'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2025-04-10'
- drug_name: Levothyroxine
  dosage: 7mg
  route_of_administration: Intravenous
  start_date: '2025-02-04'
  indication_for_use: Hypothyroidism
  end_date: '2025-04-10'
adverse_reactions:
- symptom_name: Anaphylaxis
  onset_date: '2025-02-25'
  severity: Severe
  outcome: Unknown
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2025-02-25'
  severity: Moderate
  outcome: Recovered
  intervention_required: false
- symptom_name: Angioedema
  onset_date: '2025-02-25'
  severity: Mild
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed woman and advised by.
- symptom_name: Hepatotoxicity
  onset_date: '2025-02-25'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Highly Probable
  dechallenge_rechallenge: Not applicable
  naranjo_score: 10
reporting_facility: Leblanc LLC Medical Center
reporter_type: Patient
