<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-946
Date of Submission: 2024-11-13

This report was submitted by a Pharmacist from Stewart Ltd Medical Center concerning patient ANON-PX-9059. The subject is a 49-year-old female with a significant medical history including osteoarthritis, seasonal allergies, chronic kidney disease, hypertension. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Intravenous route at a dosage of 124mg, initiated on 2024-10-13 for Pain and inflammation with the course ongoing.

On approximately 2024-10-27, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Headache, Somnolence, Hepatotoxicity. The Headache was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed house and advised kid. The current patient status regarding this symptom is 'Unknown'. The Somnolence was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Hepatotoxicity was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-946
report_date: '2024-11-13'
patient_details:
  patient_id: ANON-PX-9059
  gender: Female
  relevant_history:
  - osteoarthritis
  - seasonal allergies
  - chronic kidney disease
  - hypertension
  age_at_reaction: 49
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 124mg
  route_of_administration: Intravenous
  start_date: '2024-10-13'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
adverse_reactions:
- symptom_name: Headache
  onset_date: '2024-10-27'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed house and advised kid.
- symptom_name: Somnolence
  onset_date: '2024-10-27'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2024-10-27'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
reporting_facility: Stewart Ltd Medical Center
reporter_type: Pharmacist
