<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-656
Date of Submission: 2024-12-09

This report was submitted by a Patient from Morales, Schmitt and Williams Medical Center concerning patient ANON-PX-6741. The subject is a 57-year-old male with a significant medical history including type 2 diabetes, seasonal allergies, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin administered via the Intravenous route at a dosage of 378mg, initiated on 2024-10-08 for Hypercholesterolemia with the course ongoing; Lisinopril (ACE inhibitor) administered via the Oral route at a dosage of 239mg, initiated on 2024-10-08 for Hypertension with the course ongoing.

On approximately 2024-11-07, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Maculopapular Rash, Vomiting, Dizziness. The Hepatotoxicity was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed month and advised mother. The current patient status regarding this symptom is 'Recovered'. The Maculopapular Rash was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Vomiting was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Dizziness was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 8 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Door price late something impact also international.</data>
report_id: ADR-2024-656
report_date: '2024-12-09'
patient_details:
  patient_id: ANON-PX-6741
  gender: Male
  relevant_history:
  - type 2 diabetes
  - seasonal allergies
  - asthma
  age_at_reaction: 57
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 378mg
  route_of_administration: Intravenous
  start_date: '2024-10-08'
  indication_for_use: Hypercholesterolemia
- drug_name: Lisinopril
  dosage: 239mg
  route_of_administration: Oral
  start_date: '2024-10-08'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2024-11-07'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed month and advised mother.
- symptom_name: Maculopapular Rash
  onset_date: '2024-11-07'
  severity: Moderate
  outcome: Recovered
  intervention_required: true
- symptom_name: Vomiting
  onset_date: '2024-11-07'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2024-11-07'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
  naranjo_score: 8
reporting_facility: Morales, Schmitt and Williams Medical Center
reporter_type: Patient
notes: Door price late something impact also international.
