<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-465
Date of Submission: 2025-02-16

This report was submitted by a Nurse from King and Sons Medical Center concerning patient ANON-PX-2718. The subject is a 74-year-old male with a significant medical history including asthma, type 2 diabetes. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Subcutaneous route at a dosage of 180mg, initiated on 2025-01-09 for Hypertension with the course ongoing.

On approximately 2025-01-13, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Nausea, Headache. The Maculopapular Rash was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Fatal'. The Nausea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Headache was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 7 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-465
report_date: '2025-02-16'
patient_details:
  patient_id: ANON-PX-2718
  gender: Male
  relevant_history:
  - asthma
  - type 2 diabetes
  age_at_reaction: 74
suspected_drugs:
- drug_name: Lisinopril
  dosage: 180mg
  route_of_administration: Subcutaneous
  start_date: '2025-01-09'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2025-01-13'
  severity: Moderate
  outcome: Fatal
  intervention_required: true
- symptom_name: Nausea
  onset_date: '2025-01-13'
  severity: Moderate
  outcome: Fatal
  intervention_required: false
- symptom_name: Headache
  onset_date: '2025-01-13'
  severity: Mild
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 7
reporting_facility: King and Sons Medical Center
reporter_type: Nurse
