<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-730
Date of Submission: 2024-10-05

This report was submitted by a Nurse from Osborne-Russell Medical Center concerning patient ANON-PX-5922. The subject is a 48-year-old other with a significant medical history including type 2 diabetes, hypertension, chronic kidney disease, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Subcutaneous route at a dosage of 228mg, initiated on 2024-09-18 for Hypertension with the course ongoing; Omeprazole (Proton-pump inhibitor) administered via the Topical route at a dosage of 136mg, initiated on 2024-09-18 for Gastroesophageal reflux disease with the course ongoing.

On approximately 2024-09-30, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Nausea, Diarrhea, Stevens-Johnson syndrome, Hepatotoxicity, Vomiting. The Nausea was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed much and advised whom. The current patient status regarding this symptom is 'Recovered'. The Diarrhea was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Stevens-Johnson syndrome was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Hepatotoxicity was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Not Recovered'. The Vomiting was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed network and advised law. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 1 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-730
report_date: '2024-10-05'
patient_details:
  patient_id: ANON-PX-5922
  gender: Other
  relevant_history:
  - type 2 diabetes
  - hypertension
  - chronic kidney disease
  - asthma
  age_at_reaction: 48
suspected_drugs:
- drug_name: Lisinopril
  dosage: 228mg
  route_of_administration: Subcutaneous
  start_date: '2024-09-18'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
- drug_name: Omeprazole
  dosage: 136mg
  route_of_administration: Topical
  start_date: '2024-09-18'
  indication_for_use: Gastroesophageal reflux disease
  drug_class: Proton-pump inhibitor
adverse_reactions:
- symptom_name: Nausea
  onset_date: '2024-09-30'
  severity: Moderate
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed much and advised whom.
- symptom_name: Diarrhea
  onset_date: '2024-09-30'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-09-30'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
- symptom_name: Hepatotoxicity
  onset_date: '2024-09-30'
  severity: Severe
  outcome: Not Recovered
  intervention_required: false
- symptom_name: Vomiting
  onset_date: '2024-09-30'
  severity: Mild
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed network and advised law.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Not applicable
  naranjo_score: 1
reporting_facility: Osborne-Russell Medical Center
reporter_type: Nurse
