<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-541
Date of Submission: 2024-10-14

This report was submitted by a Pharmacist from Dudley Ltd Medical Center concerning patient ANON-PX-6679. The subject is a 47-year-old other with a significant medical history including hypertension, migraines, type 2 diabetes, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Warfarin (Anticoagulant) administered via the Intramuscular route at a dosage of 425mg, initiated on 2024-09-23 for Thromboembolism prevention and discontinued on 2024-10-04.

On approximately 2024-09-24, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Pruritus, Somnolence, Angioedema. The Vomiting was classified as Severe in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovered'. The Somnolence was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Angioedema was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed time and advised laugh. The current patient status regarding this symptom is 'Recovered'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 6 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Majority attention material them all production. Impact single there next door serve picture.</data>
report_id: ADR-2024-541
report_date: '2024-10-14'
patient_details:
  patient_id: ANON-PX-6679
  gender: Other
  relevant_history:
  - hypertension
  - migraines
  - type 2 diabetes
  - asthma
  age_at_reaction: 47
suspected_drugs:
- drug_name: Warfarin
  dosage: 425mg
  route_of_administration: Intramuscular
  start_date: '2024-09-23'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
  end_date: '2024-10-04'
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2024-09-24'
  severity: Severe
  outcome: Unknown
  intervention_required: true
- symptom_name: Pruritus
  onset_date: '2024-09-24'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
- symptom_name: Somnolence
  onset_date: '2024-09-24'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
- symptom_name: Angioedema
  onset_date: '2024-09-24'
  severity: Moderate
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed time and advised laugh.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 6
reporting_facility: Dudley Ltd Medical Center
reporter_type: Pharmacist
notes: Majority attention material them all production. Impact single there next door
  serve picture.
