<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-776
Date of Submission: 2024-08-29

This report was submitted by a Nurse from Smith, Booker and Evans Medical Center concerning patient ANON-PX-6925. The subject is a 26-year-old male with a significant medical history including coronary artery disease, chronic kidney disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Omeprazole (Proton-pump inhibitor) administered via the Topical route at a dosage of 21mg, initiated on 2024-06-16 for Gastroesophageal reflux disease with the course ongoing.

On approximately 2024-08-23, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Stevens-Johnson syndrome, Pruritus, Angioedema. The Maculopapular Rash was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Stevens-Johnson syndrome was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed central and advised return. The current patient status regarding this symptom is 'Recovering'. The Pruritus was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed pretty and advised newspaper. The current patient status regarding this symptom is 'Unknown'. The Angioedema was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 7 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Your century air book television wall technology. Theory take war future method. Bill seek new.</data>
report_id: ADR-2024-776
report_date: '2024-08-29'
patient_details:
  patient_id: ANON-PX-6925
  gender: Male
  relevant_history:
  - coronary artery disease
  - chronic kidney disease
  age_at_reaction: 26
suspected_drugs:
- drug_name: Omeprazole
  dosage: 21mg
  route_of_administration: Topical
  start_date: '2024-06-16'
  indication_for_use: Gastroesophageal reflux disease
  drug_class: Proton-pump inhibitor
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2024-08-23'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-08-23'
  severity: Mild
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed central and advised return.
- symptom_name: Pruritus
  onset_date: '2024-08-23'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed pretty and advised newspaper.
- symptom_name: Angioedema
  onset_date: '2024-08-23'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
  naranjo_score: 7
reporting_facility: Smith, Booker and Evans Medical Center
reporter_type: Nurse
notes: Your century air book television wall technology. Theory take war future method.
  Bill seek new.
