<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-857
Date of Submission: 2025-02-07

This report was submitted by a Physician from Lee PLC Medical Center concerning patient ANON-PX-2813. The subject is an adult male with a significant medical history including hypertension, coronary artery disease, osteoarthritis. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril administered via the Oral route at a dosage of 460mg, initiated on 2025-01-23 for Hypertension and discontinued on 2025-02-05.

On approximately 2025-02-01, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Nausea, Maculopapular Rash, Headache, Dizziness, Diarrhea. The Nausea was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed of and advised author. The current patient status regarding this symptom is 'Fatal'. The Maculopapular Rash was classified as Mild in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Not Recovered'. The Headache was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed whatever and advised say. The current patient status regarding this symptom is 'Fatal'. The Dizziness was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed drug and advised be. The current patient status regarding this symptom is 'Fatal'. The Diarrhea was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed upon and advised your. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 7 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-857
report_date: '2025-02-07'
patient_details:
  patient_id: ANON-PX-2813
  gender: Male
  relevant_history:
  - hypertension
  - coronary artery disease
  - osteoarthritis
suspected_drugs:
- drug_name: Lisinopril
  dosage: 460mg
  route_of_administration: Oral
  start_date: '2025-01-23'
  indication_for_use: Hypertension
  end_date: '2025-02-05'
adverse_reactions:
- symptom_name: Nausea
  onset_date: '2025-02-01'
  severity: Mild
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed of and advised author.
- symptom_name: Maculopapular Rash
  onset_date: '2025-02-01'
  severity: Mild
  outcome: Not Recovered
  intervention_required: true
- symptom_name: Headache
  onset_date: '2025-02-01'
  severity: Severe
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed whatever and advised say.
- symptom_name: Dizziness
  onset_date: '2025-02-01'
  severity: Mild
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed drug and advised be.
- symptom_name: Diarrhea
  onset_date: '2025-02-01'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed upon and advised your.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
  naranjo_score: 7
reporting_facility: Lee PLC Medical Center
reporter_type: Physician
