<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-625
Date of Submission: 2025-08-04

This report was submitted by a Physician from Morgan Ltd Medical Center concerning patient ANON-PX-9882. The subject is a 60-year-old male with a significant medical history including seasonal allergies, osteoarthritis. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril (ACE inhibitor) administered via the Oral route at a dosage of 497mg, initiated on 2025-05-28 for Hypertension and discontinued on 2025-08-03.

On approximately 2025-06-20, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Vomiting, Angioedema, Hepatotoxicity. The Vomiting was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovered'. The Angioedema was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. The Hepatotoxicity was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed region and advised there. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 7 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Negative dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Tree strategy whether contain glass result window.</data>
report_id: ADR-2025-625
report_date: '2025-08-04'
patient_details:
  patient_id: ANON-PX-9882
  gender: Male
  relevant_history:
  - seasonal allergies
  - osteoarthritis
  age_at_reaction: 60
suspected_drugs:
- drug_name: Lisinopril
  dosage: 497mg
  route_of_administration: Oral
  start_date: '2025-05-28'
  indication_for_use: Hypertension
  drug_class: ACE inhibitor
  end_date: '2025-08-03'
adverse_reactions:
- symptom_name: Vomiting
  onset_date: '2025-06-20'
  severity: Severe
  outcome: Recovered
  intervention_required: false
- symptom_name: Angioedema
  onset_date: '2025-06-20'
  severity: Moderate
  outcome: Unknown
  intervention_required: false
- symptom_name: Hepatotoxicity
  onset_date: '2025-06-20'
  severity: Moderate
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed region and advised there.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Negative dechallenge
  naranjo_score: 7
reporting_facility: Morgan Ltd Medical Center
reporter_type: Physician
notes: Tree strategy whether contain glass result window.
