<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-980
Date of Submission: 2024-12-06

This report was submitted by a Physician from Ritter Ltd Medical Center concerning patient ANON-PX-8097. The subject is a 44-year-old male with a significant medical history including anxiety, coronary artery disease, seasonal allergies, chronic kidney disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Atorvastatin (Statin) administered via the Intravenous route at a dosage of 272mg, initiated on 2024-11-03 for Hypercholesterolemia and discontinued on 2024-11-19; Ibuprofen administered via the Subcutaneous route at a dosage of 130mg, initiated on 2024-11-03 for Pain and inflammation and discontinued on 2024-11-19.

On approximately 2024-11-18, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Diarrhea, Maculopapular Rash, Headache. The Angioedema was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. The Diarrhea was classified as Severe in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Maculopapular Rash was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed newspaper and advised character. The current patient status regarding this symptom is 'Fatal'. The Headache was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 4 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: General moment believe hotel sing age region. Under crime civil part. Study support success difficult member increase nor.</data>
report_id: ADR-2024-980
report_date: '2024-12-06'
patient_details:
  patient_id: ANON-PX-8097
  gender: Male
  relevant_history:
  - anxiety
  - coronary artery disease
  - seasonal allergies
  - chronic kidney disease
  age_at_reaction: 44
suspected_drugs:
- drug_name: Atorvastatin
  dosage: 272mg
  route_of_administration: Intravenous
  start_date: '2024-11-03'
  indication_for_use: Hypercholesterolemia
  drug_class: Statin
  end_date: '2024-11-19'
- drug_name: Ibuprofen
  dosage: 130mg
  route_of_administration: Subcutaneous
  start_date: '2024-11-03'
  indication_for_use: Pain and inflammation
  end_date: '2024-11-19'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2024-11-18'
  severity: Moderate
  outcome: Recovering
  intervention_required: true
- symptom_name: Diarrhea
  onset_date: '2024-11-18'
  severity: Severe
  outcome: Recovering
  intervention_required: false
- symptom_name: Maculopapular Rash
  onset_date: '2024-11-18'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed newspaper and advised character.
- symptom_name: Headache
  onset_date: '2024-11-18'
  severity: Moderate
  outcome: Unknown
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 4
reporting_facility: Ritter Ltd Medical Center
reporter_type: Physician
notes: General moment believe hotel sing age region. Under crime civil part. Study
  support success difficult member increase nor.
