<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-507
Date of Submission: 2025-05-04

This report was submitted by a Pharmacist from Long, Dunn and Williamson Medical Center concerning patient ANON-PX-2020. The subject is a 71-year-old male with a significant medical history including osteoarthritis, asthma. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Topical route at a dosage of 193mg, initiated on 2025-03-23 for Pain and inflammation and discontinued on 2025-05-03; Sertraline (SSRI) administered via the Subcutaneous route at a dosage of 109mg, initiated on 2025-03-23 for Major depressive disorder and discontinued on 2025-05-03.

On approximately 2025-04-26, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Angioedema, Dizziness, Headache, Nausea. The Angioedema was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. The Dizziness was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed think and advised mean. The current patient status regarding this symptom is 'Unknown'. The Headache was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed discuss and advised first. The current patient status regarding this symptom is 'Unknown'. The Nausea was classified as Life-threatening in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Up great focus peace everyone describe avoid. Lot son agent pressure those. Cut side boy federal.</data>
report_id: ADR-2025-507
report_date: '2025-05-04'
patient_details:
  patient_id: ANON-PX-2020
  gender: Male
  relevant_history:
  - osteoarthritis
  - asthma
  age_at_reaction: 71
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 193mg
  route_of_administration: Topical
  start_date: '2025-03-23'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2025-05-03'
- drug_name: Sertraline
  dosage: 109mg
  route_of_administration: Subcutaneous
  start_date: '2025-03-23'
  indication_for_use: Major depressive disorder
  drug_class: SSRI
  end_date: '2025-05-03'
adverse_reactions:
- symptom_name: Angioedema
  onset_date: '2025-04-26'
  severity: Life-threatening
  outcome: Fatal
  intervention_required: false
- symptom_name: Dizziness
  onset_date: '2025-04-26'
  severity: Life-threatening
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed think and advised mean.
- symptom_name: Headache
  onset_date: '2025-04-26'
  severity: Severe
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed discuss and advised first.
- symptom_name: Nausea
  onset_date: '2025-04-26'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Not applicable
reporting_facility: Long, Dunn and Williamson Medical Center
reporter_type: Pharmacist
notes: Up great focus peace everyone describe avoid. Lot son agent pressure those.
  Cut side boy federal.
