<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-994
Date of Submission: 2025-04-02

This report was submitted by a Other Healthcare Professional from Simpson and Sons Medical Center concerning patient ANON-PX-5592. The subject is a 33-year-old other with a significant medical history including osteoarthritis, type 2 diabetes, chronic kidney disease, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Omeprazole (Proton-pump inhibitor) administered via the Subcutaneous route at a dosage of 203mg, initiated on 2025-01-23 for Gastroesophageal reflux disease and discontinued on 2025-03-28; Amoxicillin (Penicillin antibiotic) administered via the Subcutaneous route at a dosage of 294mg, initiated on 2025-01-23 for Bacterial infection and discontinued on 2025-03-28.

On approximately 2025-02-22, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Headache, Angioedema, Anaphylaxis. The Headache was classified as Moderate in severity. This necessitated clinical intervention. The current patient status regarding this symptom is 'Unknown'. The Angioedema was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed be and advised man. The current patient status regarding this symptom is 'Fatal'. The Anaphylaxis was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed should and advised will. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 7 was calculated, The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive rechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Home whatever loss person agreement you. Republican explain decide traditional option Democrat plan.</data>
report_id: ADR-2025-994
report_date: '2025-04-02'
patient_details:
  patient_id: ANON-PX-5592
  gender: Other
  relevant_history:
  - osteoarthritis
  - type 2 diabetes
  - chronic kidney disease
  - atrial fibrillation
  age_at_reaction: 33
suspected_drugs:
- drug_name: Omeprazole
  dosage: 203mg
  route_of_administration: Subcutaneous
  start_date: '2025-01-23'
  indication_for_use: Gastroesophageal reflux disease
  drug_class: Proton-pump inhibitor
  end_date: '2025-03-28'
- drug_name: Amoxicillin
  dosage: 294mg
  route_of_administration: Subcutaneous
  start_date: '2025-01-23'
  indication_for_use: Bacterial infection
  drug_class: Penicillin antibiotic
  end_date: '2025-03-28'
adverse_reactions:
- symptom_name: Headache
  onset_date: '2025-02-22'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
- symptom_name: Angioedema
  onset_date: '2025-02-22'
  severity: Moderate
  outcome: Fatal
  intervention_required: true
  intervention_details: Prescribed be and advised man.
- symptom_name: Anaphylaxis
  onset_date: '2025-02-22'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed should and advised will.
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive rechallenge
  naranjo_score: 7
reporting_facility: Simpson and Sons Medical Center
reporter_type: Other Healthcare Professional
notes: Home whatever loss person agreement you. Republican explain decide traditional
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