<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-219
Date of Submission: 2025-04-15

This report was submitted by a Nurse from Martin PLC Medical Center concerning patient ANON-PX-2455. The subject is a 78-year-old female with a significant medical history including osteoarthritis, seasonal allergies. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Warfarin (Anticoagulant) administered via the Subcutaneous route at a dosage of 441mg, initiated on 2025-02-12 for Thromboembolism prevention with the course ongoing; Sertraline administered via the Intravenous route at a dosage of 392mg, initiated on 2025-02-12 for Major depressive disorder with the course ongoing.

On approximately 2025-04-10, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Maculopapular Rash, Pruritus, Stevens-Johnson syndrome. The Maculopapular Rash was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed cover and advised suggest. The current patient status regarding this symptom is 'Unknown'. The Pruritus was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed method and advised range. The current patient status regarding this symptom is 'Recovering'. The Stevens-Johnson syndrome was classified as Mild in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 2 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Step age article visit maintain opportunity option. Eight idea serious care into.</data>
report_id: ADR-2025-219
report_date: '2025-04-15'
patient_details:
  patient_id: ANON-PX-2455
  gender: Female
  relevant_history:
  - osteoarthritis
  - seasonal allergies
  age_at_reaction: 78
suspected_drugs:
- drug_name: Warfarin
  dosage: 441mg
  route_of_administration: Subcutaneous
  start_date: '2025-02-12'
  indication_for_use: Thromboembolism prevention
  drug_class: Anticoagulant
- drug_name: Sertraline
  dosage: 392mg
  route_of_administration: Intravenous
  start_date: '2025-02-12'
  indication_for_use: Major depressive disorder
adverse_reactions:
- symptom_name: Maculopapular Rash
  onset_date: '2025-04-10'
  severity: Mild
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed cover and advised suggest.
- symptom_name: Pruritus
  onset_date: '2025-04-10'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: true
  intervention_details: Prescribed method and advised range.
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2025-04-10'
  severity: Mild
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 2
reporting_facility: Martin PLC Medical Center
reporter_type: Nurse
notes: Step age article visit maintain opportunity option. Eight idea serious care
  into.
