<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-818
Date of Submission: 2024-12-03

This report was submitted by a Physician from Bradley-Marsh Medical Center concerning patient ANON-PX-1974. The subject is a 84-year-old female with a significant medical history including osteoarthritis, hypertension, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Sertraline administered via the Intravenous route at a dosage of 136mg, initiated on 2024-10-16 for Major depressive disorder and discontinued on 2024-11-05; Ibuprofen (NSAID) administered via the Intramuscular route at a dosage of 481mg, initiated on 2024-10-16 for Pain and inflammation and discontinued on 2024-11-05.

On approximately 2024-10-21, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Stevens-Johnson syndrome, Pruritus, Headache. The Stevens-Johnson syndrome was classified as Life-threatening in severity. This necessitated clinical intervention. The documented action was: Prescribed worker and advised charge. The current patient status regarding this symptom is 'Recovered'. The Pruritus was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed artist and advised another. The current patient status regarding this symptom is 'Recovered'. The Headache was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed never and advised maybe. The current patient status regarding this symptom is 'Unknown'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 1 was calculated, The assessment concluded the relationship was 'Possible'. Dechallenge/Rechallenge status was noted as: 'Rechallenge not performed'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2024-818
report_date: '2024-12-03'
patient_details:
  patient_id: ANON-PX-1974
  gender: Female
  relevant_history:
  - osteoarthritis
  - hypertension
  - atrial fibrillation
  age_at_reaction: 84
suspected_drugs:
- drug_name: Sertraline
  dosage: 136mg
  route_of_administration: Intravenous
  start_date: '2024-10-16'
  indication_for_use: Major depressive disorder
  end_date: '2024-11-05'
- drug_name: Ibuprofen
  dosage: 481mg
  route_of_administration: Intramuscular
  start_date: '2024-10-16'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-11-05'
adverse_reactions:
- symptom_name: Stevens-Johnson syndrome
  onset_date: '2024-10-21'
  severity: Life-threatening
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed worker and advised charge.
- symptom_name: Pruritus
  onset_date: '2024-10-21'
  severity: Severe
  outcome: Recovered
  intervention_required: true
  intervention_details: Prescribed artist and advised another.
- symptom_name: Headache
  onset_date: '2024-10-21'
  severity: Moderate
  outcome: Unknown
  intervention_required: true
  intervention_details: Prescribed never and advised maybe.
causality_assessment:
  assessment_conclusion: Possible
  dechallenge_rechallenge: Rechallenge not performed
  naranjo_score: 1
reporting_facility: Bradley-Marsh Medical Center
reporter_type: Physician
