<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2025-723
Date of Submission: 2025-08-11

This report was submitted by a Physician from Vargas-Gonzalez Medical Center concerning patient ANON-PX-5009. The subject is a 29-year-old other with a significant medical history including type 2 diabetes, migraines, osteoarthritis, atrial fibrillation. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Lisinopril administered via the Intravenous route at a dosage of 399mg, initiated on 2025-05-26 for Hypertension with the course ongoing.

On approximately 2025-05-29, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Pruritus, Diarrhea. The Pruritus was classified as Moderate in severity. This necessitated clinical intervention. The documented action was: Prescribed day and advised pass. The current patient status regarding this symptom is 'Not Recovered'. The Diarrhea was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Fatal'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. The assessment concluded the relationship was 'Probable'. Dechallenge/Rechallenge status was noted as: 'Positive dechallenge'. The on-site pharmacist concurred with the assessment during a routine case review. 

</data>
report_id: ADR-2025-723
report_date: '2025-08-11'
patient_details:
  patient_id: ANON-PX-5009
  gender: Other
  relevant_history:
  - type 2 diabetes
  - migraines
  - osteoarthritis
  - atrial fibrillation
  age_at_reaction: 29
suspected_drugs:
- drug_name: Lisinopril
  dosage: 399mg
  route_of_administration: Intravenous
  start_date: '2025-05-26'
  indication_for_use: Hypertension
adverse_reactions:
- symptom_name: Pruritus
  onset_date: '2025-05-29'
  severity: Moderate
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed day and advised pass.
- symptom_name: Diarrhea
  onset_date: '2025-05-29'
  severity: Moderate
  outcome: Fatal
  intervention_required: false
causality_assessment:
  assessment_conclusion: Probable
  dechallenge_rechallenge: Positive dechallenge
reporting_facility: Vargas-Gonzalez Medical Center
reporter_type: Physician
