<format type="yaml">{report_id: string, report_date: date, patient_details: {patient_id: string, age_at_reaction: number optional, gender: string, relevant_history: list[string]}, suspected_drugs: list[{drug_name: string, drug_class: string optional, dosage: string, route_of_administration: string, start_date: date, end_date: date optional, indication_for_use: string}], adverse_reactions: list[{symptom_name: string, onset_date: date, severity: string, outcome: string, intervention_required: boolean, intervention_details: string optional}], causality_assessment: {naranjo_score: number optional, assessment_conclusion: string, dechallenge_rechallenge: string}, reporting_facility: string, reporter_type: string, notes: string optional}</format> <data>PHARMACOVIGILANCE CASE REPORT - CONFIDENTIAL
Report Identifier: ADR-2024-483
Date of Submission: 2024-12-07

This report was submitted by a Physician from Chavez, Riley and Wilson Medical Center concerning patient ANON-PX-1786. The subject is an adult male with a significant medical history including migraines, coronary artery disease. The facility's standard operating procedure for ADR reporting was followed, and all patient data has been anonymized. The patient chart was reviewed for comorbidities. 

Current medication review revealed the following suspected agent(s): Ibuprofen (NSAID) administered via the Oral route at a dosage of 149mg, initiated on 2024-09-11 for Pain and inflammation and discontinued on 2024-11-02.

On approximately 2024-10-23, the patient began to manifest an adverse event. The primary symptoms noted in the clinical log were Hepatotoxicity, Vomiting, Nausea, Diarrhea. The Hepatotoxicity was classified as Severe in severity. This necessitated clinical intervention. The documented action was: Prescribed teach and advised general. The current patient status regarding this symptom is 'Not Recovered'. The Vomiting was classified as Moderate in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. The Nausea was classified as Mild in severity. This necessitated clinical intervention. The documented action was: Prescribed direction and advised him. The current patient status regarding this symptom is 'Not Recovered'. The Diarrhea was classified as Life-threatening in severity. No specific therapeutic intervention was required. The current patient status regarding this symptom is 'Recovering'. 

CAUSALITY ASSESSMENT:
An evaluation of causality was performed. A Naranjo score of 10 was calculated, The assessment concluded the relationship was 'Highly Probable'. Dechallenge/Rechallenge status was noted as: 'Not applicable'. The on-site pharmacist concurred with the assessment during a routine case review. 

Reporter's Narrative Summary: Test firm focus put move result experience. Into how evidence executive lawyer seat sign. Conference watch trip want upon.</data>
report_id: ADR-2024-483
report_date: '2024-12-07'
patient_details:
  patient_id: ANON-PX-1786
  gender: Male
  relevant_history:
  - migraines
  - coronary artery disease
suspected_drugs:
- drug_name: Ibuprofen
  dosage: 149mg
  route_of_administration: Oral
  start_date: '2024-09-11'
  indication_for_use: Pain and inflammation
  drug_class: NSAID
  end_date: '2024-11-02'
adverse_reactions:
- symptom_name: Hepatotoxicity
  onset_date: '2024-10-23'
  severity: Severe
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed teach and advised general.
- symptom_name: Vomiting
  onset_date: '2024-10-23'
  severity: Moderate
  outcome: Recovering
  intervention_required: false
- symptom_name: Nausea
  onset_date: '2024-10-23'
  severity: Mild
  outcome: Not Recovered
  intervention_required: true
  intervention_details: Prescribed direction and advised him.
- symptom_name: Diarrhea
  onset_date: '2024-10-23'
  severity: Life-threatening
  outcome: Recovering
  intervention_required: false
causality_assessment:
  assessment_conclusion: Highly Probable
  dechallenge_rechallenge: Not applicable
  naranjo_score: 10
reporting_facility: Chavez, Riley and Wilson Medical Center
reporter_type: Physician
notes: Test firm focus put move result experience. Into how evidence executive lawyer
  seat sign. Conference watch trip want upon.
