ki te wāhanga i raro nei, a ka whakahoki i te pātai i muri i roto i te reo ano rite te wāhanga: wāhanga: maha whakakapi nucleophilic puta māmā kore ki pyridine tahanga, engari ki pyridine whakarerekētia ki bromine, chlorine, fluorine, ranei waikawa sulfonic e ka riro i te rōpū mahue. Na fluorine ko te rōpū mahue pai mo te whakakapi ki ngā pūhui organolithium. Ko te nucleophilic whakaeke pūhui kia alkoxides, thiolates, amine, me te amonia (i te pēhanga tiketike). I roto i te whānui, ko te pūhui hydride he rōpū mahue rawakore, me te puta anake i roto i te torutoru tauhohenga heterocyclic. ngā ratou i te tauhohenga chichibabin, e yields pyridine derivatives aminated i te tūranga 2-. konei, whakamahia amide konupūmā hei te nucleophile yielding muri 2-pyridine. Ko te ion hydride tukua i roto i tenei tauhohenga ngā ki te proton o te rōpū amino benzene
nucleophile e hua ana i te 2-aminopyridine