Ka taea e ngā cofactors kia rānei inorganic (hei tauira, ions whakarewa, me te rino-ngaro kohinga) ranei pūhui organic (hei tauira, flavin me te heme). e mahi enei cofactors maha ngā take; hei tauira, ka taea e ions whakarewa te āwhina i roto i te stabilizing ngā momo nucleophilic i roto i te pae kaha. Ka taea e ngā cofactors organic kia rānei coenzymes, e tukua i te pae kaha o te whākōkī i roto i te tauhohenga, ranei rōpū prosthetic, e e piri piri ki te whākōkī. taea e ngā rōpū prosthetic organic kia covalently (hei tauira, i roto i ngā whākōkī pērā i carboxylase biotin).
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