I roto i te 1885, i tangohia e Wilhelm Roux tetahi wahi o te papa medullary o te heihei embryonic ka puritia te reira i roto i te otinga tote mahana mo te maha o nga ra, te whakatūnga i te parau tumu o te ahurea kiko. Ross Granville Harrison, mahi i Johns Hopkins Medical School, ka i te Whare Wānanga o Yale, whakaputaina hua o ana whakamātautau i 1907 ki 1910, te whakatūnga i te tikanga o te ahurea kiko. I tino matatau ngā tikanga ahurea pūtau i roto i te 1940s me 1950s ki te tautoko i te rangahau i roto i te virology. tupu i roto i ngā ahurea pūtau whakaaetia te faaineineraa o ngā hua pūtau purea mō te hanga o te kano ārai. i whakawhanakehia te kano ārai mate polio e Jonas Salk i te whakamahi i tetahi o nga hua pūtau ārai-whakapua i roto i te tinana o te heihei.
Ko te tau 1885