I whakaurua i te mutunga o te rautau 19, ko te phenacetin he waahanga noa o nga analgesics whakauru i nga waahanga o Uropi, Ahitereiria, me te United States. I roto i enei analgesics whakauru ko te aspirin me etahi atu NSAID me te phenacetin, paracetamol, salicylamide, me te kawheine, te waehere ranei. I roto i nga tau 1950, Spühler me Zollinger i kii he hononga i waenga i te whara o te whatukuhu me te whakamahinga o te phenacetin. I kii ratou kua piki te kaha o te phenacetin i waenga i te hunga mate pukupuku me te mate pukupuku. I te mutunga o te tau 1990, ko te phenacetin i whakaheke i te mate pukupuku i waenga i te hunga mate pukupuku me etahi atu momo mate pukupuku.
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