Ka tīmata te raupapa i te marama o Hepetema 2005 ki a Ted (Josh Radnor) hei hoa kotahi, 27 tau te pakeke, e noho ana ki ona hoa pai e rua mai i ona tau o te kura: Marshall Eriksen (Jason Segel), he akonga ture, me Lily Aldrin (Alyson Hannigan), he kaiako kura tamariki me te kaitoi e hiahia ana. Kua tata ki te iwa tau a Lily me Marshall i te wa e tono ana a Marshall. Ko ta raua whakaipoipo ka whakaaro a Ted mo te marena me te kimi i tana hoa wairua, he nui te whakarihariha o tana hoa pai i whakaingoatia e ia ano a Barney Stinson (Neil Patrick Harris), i tutaki ia ki te wharepaku i te paari e wha tau ki muri. Ko Barney he wahine wahine wahine e whakaari ana i nga taakaro tinihanga, ko te nuinga o nga kakahu me nga tuakiri teka, i hangaia hei moe i nga wahine, kia ngaro noa te hiahia ki a raatau i muri tonu i te tutaki.
wharepaku