I roto i te waenganui o nga tau 1970, Harvey J. Alter, Tiamana o te Wāhanga mate hopuhopu i roto i te Tari o Transfusion Medicine i te National Institutes o te Hauora, me tona rōpū rangahau whakaaturia pehea te nuinga o ngā take mate hopuhopu i muri-whakamarie kihai i tika ki te mate hopuhopu A ranei B huaketo. Ahakoa tenei kitenga, ngā kaha rangahau ao ki te tautuhi i te huaketo, i te tīmatanga i huaina kore-A, kore-B mate hopuhopu (NANBH), i kore mo te tekau tau i muri mai. I roto i te 1987, Michael Houghton, Qui-Lim Choo, ko George Kuo i Chiron Corporation, mahi tahi ki a Daniel W. Bradley i te Centers for Disease Control and Prevention, whakamahia he huarahi hou cloning rāpoi ngota ki te tautuhi i te rauropi unknown me te whakamātautau tātaritanga. I roto i te 1970 Alter whakapumautia e te aroaro o te huaketo i roto i te rōpū o NANB tauira tātaritanga. I roto i te April 1989, whakaputa
1987 Ko te