Tirohia te wāhanga i raro nei, kātahi ka whakautu i te pātai i muri mai i te reo kotahi me te wāhanga:  Putanga: Ko nga ariā mo te whakaheke toto kua noho mai i nga wa onamata. I whakaahuatia e te kairangahau tinana a Johannes Müller (1801<unk>1858) te fibrin, te matū o te thrombus. Na Rudolf Virchow (1821<unk>1902) i tapaina te ingoa o tana kaitohutohu wairewa, ko te fibrinogen, a ko Prosper Sylvain Denis (1799<unk>1863) i wehewehe i te matū. I whakaaro a Alexander Schmidt ko te hurihanga mai i te fibrinogen ki te fibrin te hua o te tukanga whākōkī, a ka tapaina te whākōkī whakapae "thrombin" me tana "prothrombin". I kitea e Arthus i te tau 1890 he mea nui te konupora ki te whakaheke toto. I kitea nga platelets i te tau 1865, a, i whakamaramatia to raatau mahi e Giulio Bizzozero i te 1882. Ko te ariā e hangaia ana te thrombin e te aroaro o te take kiko i whakakahahia e Paul Morawitz i te 1905. I tēnei wā, e mōhiotia ana ko te thrombokinase/thromboplastin (taonga III) e tukuna ana e nga kiko kua pakaru, e urupare ana ki te prothrombin (II), e, me te konupūmā (IV), e hanga ana i te thrombin, e huri ana i te fibrinogen ki te fibrin (I).  Pātai: I noho a Muller i tehea wā?
1801<unk>1858 Ko te