I roto i te 1543, Andreas Vesalius whakaurua te wā o nāianei o te rongoā ki te Uru ki tona raupapa whakamātautau tinana tangata De humani corporis fabrica, i hāngai ki runga ki te whakawātea o te tinana. ko Vesalius te tuatahi i roto i te raupapa o anatomists nei āta whakakapi scholasticism ki empiricism i roto i te tinana me te rongoā, whakawhirinaki i runga i te wheako tuatahi-ringa, kaua ki te mana, me te whakaaro ātaahua. Na roto i te herbalism, rongoā i hoki āta te puna o te empiricism whakahoutia i roto i te ako o te tipu. tuhituhi Otto Brunfels, Hieronymus Bock ko Leonhart Fuchs whānui i runga i te tipu, te timatanga o te āhua-e hāngai ana huarahi ki te whānuitanga o te ora tipu.
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