Ko te tikanga, ko te fibrinogen, ko te matamua o te fibrinogen, i tapaina e Rudolf Virchow (1821-1902), a ka wehehia e Prosper Sylvain Denis (1799-1863). I whakaaro a Alexander Schmidt ko te hurihanga mai i te fibrinogen ki te fibrin he hua o te tukanga enzymatic, a ka tapaina te whākōkī "thrombin" me tana "prothrombin". I kitea e Arthus i te tau 1890 ko te konupora he mea nui ki te coagulation. I kitea nga papa i te tau 1865, a, i whakaahuatia e Giulio Bizzoid i te tau 1882. Ko te ariā ko te aroaro o te thrombin i whakakotahihia e te Paul Morawitz i roto i tenei waahanga, i whakauruhia e te Atombombine (I / IV), i te mea i puta mai i roto i nga papanga kua pakaru i roto i te papanga, i te mea i puta mai i te whākōkī ki te fibrinogen.
1801<unk>1858 Ko te