Ko te mate o Alzheimer kua tautuhia hei mate poroteini misfolding (proteopathy), i puta mai i te kohinga papa o te pūmua amyloid beta me te pūmua tau i roto i te roro. Kei roto i enei papa nga peptides iti, 39<unk>43 waikawa amino i te roa, e kiia ana ko te beta amyloid (Aβ). Ko te Aβ he waahanga mai i te pūmua amyloid precursor nui (APP). Ko te APP he pūmua transmembrane e uru atu ana ki te membrane o te neuron. He mea nui te APP ki te tipu o te neuron, te oranga, me te whakatika i muri i te whara. I te mate o Alzheimer, ka mahi tahi te gamma secretase me te beta secretase i roto i te tukanga pūmua e wehewehea ai te APP ki nga waahanga iti ake. Ko tetahi o enei waahanga ka ara ake ki te kohinga o te beta amyloid, e pupuhi ana i waho o te neuronal, e kiia ana ko te amyloid beta (Aβ). Ko te Aβ he waahanga mai i te nui ake o te pūmua
pūmua pātahi-microtubule