I whakaingoatia te mate i muri i a Harry Klinefelter, i mahi tahi me Fuller Albright me E. C. Reifenstein i te Massachusetts General Hospital i Boston, Massachusetts, i te tau kotahi ano. I mohiotia te korero a Klinefelter ko te mate a Klinefelter i te mea i puta tuatahi tana ingoa i runga i te pepa i whakaputaina, a kaore ano i whakamahia te dysgenesis tubule seminiferous. Ki te whakaaro ki nga ingoa o nga kairangahau e toru, i etahi wa ka kiia ko Klinefelter-Reifenstein-Albright. I te 1956 i kitea ko te mate a Klinefelter na te chromosome taapiri. I kitea e Plunkett me Barr te chromatin sex i roto i te tinana o te tinana o te tinana. I whakamaramahia ano tenei hei XXYY i te 1959 e John Jacobs me John Anderson Strong. Ko te ripoata tuatahi i whakaputaina mo te tangata 47, he karosotype XXYY, i whakaputaina e John Jacobs me Patricia Strong.
Ko te tau 1959