I kitea i roto i te 1950s me te kē huaina globulin antihemophilic no te mea o tona kaha ki te whakatika hemophilia A. kitea Factor IX i roto i 1952 i roto i te turoro taitamariki ki hemophilia B huaina Stephen Christmas (1947<unk>1993). i whakaahuatia tona korenga e Dr. Rosemary Biggs me te Ahorangi R.G. MacFarlane i Oxford, UK. huaina te take te reira, Christmas Factor. noho Christmas i roto i Canada, ka pakanga mo te haumaru toto whakaheke tae noa hinga ki te toto-e pā ana AIDS i te tau 46. he ingoa kē mo te take ko plasma thromboplastin, i homai e te rōpū motuhake i roto i California.
e mate ana ki te mate AIDS e pā ana ki te whakaheke toto