Pasage: Sanggeus ngamimitian karirna di panggung, Anderson ngahontal pangakuan internasional pikeun peranna salaku Agen Khusus FBI Dana Scully dina séri drama fiksi ilmiah Amérika The X-Files. Karya pilemna kalebet drama The Mighty Celt (2005), The Last King of Scotland (2006), Shadow Dancer (2012), Viceroy's House (2017) sareng dua pilem X-Files: The X-Files: Fight the Future (1998) sareng The X-Files: I Want to Believe (2008). Kredit televisi anu sanésna kalebet: Lady Dedlock in Bleak House (2005), Wallis in Any Simpson Human Heart (2010), Miss Havisham in Great Expectations (2011), Dr. Maurilia Duer Hannibal (2013-2015), sareng on Media Gods (2017).
The X-Files