Salazar diinget ti Triple-A Columbus Clippers dina 11 Juli 2013, sarta nyieun debut baseball Liga Utama na salaku pitcher dimimitian ngalawan Toronto Blue Jays. Manéhna nyokot hiji no-hitter kana 6th inning, striking kaluar tujuh batters dina genep pinuh-innings gawé, strikeouts paling pikeun hiji India 'ngawitan pitcher di debut Liga Utama na saprak Luis Tiant struck kaluar sabelas batters di debut di 1964. Manéhna diopsi deui ka Columbus dina 12 Juli. Danny Salazar disebut pikeun nyieun titik mimiti dina 7 Agustus 2013, ngalawan Detroit Tigers. Salazar nyieun karir kahijina pasca-musim dimimitian pikeun India ngalawan Tampa Bay Rays di 2013 American League Wild Card Game
. tapi