>, <em>Citadel</em>) must be accessible from it. See the
<a href=/v1.7/docs/examples/virtual-machines/>Istio VM-related</a> tasks for more details.</p><p>In our case, the MySQL instance can run on any machine or can be provisioned as a service by a cloud provider. There is
no requirement to integrate the machine with Istio. The Istio control plane does not have to be accessible from the
machine. In the case of MySQL as a service, the machine which MySQL runs on may be not accessible and installing on it
the