<!DOCTYPE html>
<html>
  <head>
    <style>
      .wrapper {
        display: grid;
        grid-template-columns: 20% minmax(50px, max-content) 1fr 3fr;
        grid-template-rows: 1fr minmax(50px, 100px) 3fr 100px;
      }
	  
	  .wrapper > div {
      border: 2px solid blue;
	  }

    .box5 {
        grid-column-start: 1;
        grid-column-end: 3;
        grid-row-start: 2;
        grid-row-end: 4;
      }
    </style>
  </head>

  <body>
    <div class="wrapper">
      <div>One</div>
      <div>Two Tw