ent non-synonymous changes in a codon, or even major effects like
interfering with start or stop codons.</p>
<p>Trying to figure out whether a variant occurs in a position within a coding
sequence that will create an amino acid change can
be done by figuring out whether the variant is in a coding sequence and whether the
sequence change causes a non-synonymous change in the codon that it is in, etc. Doing so
by writing your own scripts is hard and subject to a lot of error. (I know, because
I spent a good s