tory routes. Some of the indomethacin is excreted in the bile and reabsorbed by the intestine. This phenomenon, called enterohepatic circulation, keeps the drug around longer than would be expected otherwise. <br />
Each subject in Study 1 (intravenous route) received a single 50 mg dose of radioactively labeled indomethacin (^14^-carbon-labeled, with each dose containing 25 microCuries of radioactivity). Subjects received a standard meal (one 8-oz can of Metrecal, 8 oz of whole milk, and one medium-size ap