s. This is required if fetching HGVS annotations (--hgvs)
or checking reference sequences (--check_ref) in offline mode (--offline),
and optional with some performance increase in cache mode (--cache).
See documentation for more details. Not used by default</p></td>
    </tr>
    <tr>
      <th>everything</th>
      <td><p>Shortcut flag to switch on all of the following:
--sift b, --polyphen b, --ccds, --uniprot, --hgvs, --symbol, --numbers,
--domains, --regulatory, --canonical, --protein, --biotype, --unip