span class="n"><span class="pre">n_top_genes</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#splicejac.tools.estimate_jacobian.initial_check" title="Permalink to this definition"></a></dt>
<dd><p>Check that the selected number of genes (n_top_genes) does not exceed the number of observables</p>
<p>The maximum value admitted for the n_top_genes variable to ensure a unique solution is given by the number of cells
in the smaller cluster times the fraction of cells per cluster 