portant.html">requires less sample DNA than array-base capture</a>. To enrich for coding sequences, in-solution capture has a pool of custom probes that are designed to bind to the coding regions in the sample. Attached to these probes are beads which can be physically separated from DNA that is not bound to the probes (this should be the non-coding sequences) <span class="citation">(<a href="#ref-Mamanova2010" role="doc-biblioref">Mamanova et al. 2010</a>)</span>.<br />
- <a href="https://www.ncbi.nlm.nih.