" href="#splicejac.tools.estimate_jacobian.estimate_jacobian" title="Permalink to this definition"></a></dt>
<dd><p>Run cluster-wise Jacobian inference</p>
<dl class="simple">
<dt>adata: <cite>~anndata.AnnData</cite></dt><dd><p>count matrix</p>
</dd>
<dt>first_moment: <cite>Bool</cite> (default: True)</dt><dd><p>if True, use first moment of U and S to run regression</p>
</dd>
<dt>method: <cite>str</cite> (default: Ridge)</dt><dd><p>regression method, choose between Linear, Ridge or Lasso</p>
</dd>
<dt>al