tion_(genetics)" title="Transcription (genetics)">gene transcript</a> (<a href="//en.wikipedia.org/wiki/Expressed_sequence_tag" title="Expressed sequence tag">ESTs</a>).</p>
<p>The problem of sequence assembly can be compared to taking many copies of a book, passing each of them through a shredder with a different cutter, and piecing the text of the book back together just by looking at the shredded pieces. Besides the obvious difficulty of this task, there are some extra practical issues: the original may 