te_ref-1" class="reference"><a href="#cite_note-1"><span>[</span>1<span>]</span></a></sup> and Arachne<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span>[</span>2<span>]</span></a></sup> able to handle genomes of 100-300 million base pairs. Subsequent to these efforts, several other groups, mostly at the major genome sequencing centers, built large-scale assemblers, and an open source effort known as AMOS<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span>[</span>3<span>]</s