ardial
tissue structure. However, little is known about ion currents in human
cardiac fibroblasts. It has been recently reported that cardiac
fibroblasts can interact electrically with cardiomyocytes through gap
junctions. Ca(2+)- activated K(+) currents (I (K[Ca])) of cultured
human cardiac fibroblasts were characterized in this study. In
whole-cell configuration, depolarizing pulses evoked I (K(Ca)) in an
outward rectification in these cells, the amplitude of which was
suppressed by paxilline (1 microM) o