       2       1
## 1:196682947       2       2       1
## 1:196654324       1       2       1
</code></pre>

<p>Note here we require a gene file in refFlat format. We have prepared several gene definition files in refFlat format using NCBI human build 37.
From this website, you can obtain these resources files.</p>

<p>The supported annotation variant type are: </p>

<pre><code># large strucutre variant
StructuralVariation

# indels
Stop_Gain
Stop_Loss
Start_Gain
Start_Loss
Frameshift        /* Indel lengt