/a> card) you can use files in mary's area <i>e.g.,</i>
    specify the following line in the control file:<br>
    <tt>radius ~mary/hole2/rad/simple.rad</tt><br>
    (HOLE now resolves ~'s for user names).
</ul>

<a name=science><h3>2.2 Brief scientific background to the hole method </h3>

The first version of 
HOLE was written at Birkbeck College from April 1992 to allow the visualization
and analysis of the holes through atomic models of ion channels.  
At the time a number of
people have suggested that 