
</ul>
</div>
<p></p>
<h2><span class="mw-headline" id="Genome_assemblers">Genome assemblers</span></h2>
<p>The first sequence assemblers began to appear in the late 1980s and early 1990s as variants of simpler <a href="//en.wikipedia.org/wiki/Sequence_alignment" title="Sequence alignment">sequence alignment</a> programs to piece together vast quantities of fragments generated by automated sequencing instruments called <a href="//en.wikipedia.org/wiki/DNA_sequencers" title="DNA sequencers" class="mw-redirec