><p><strong>Forward-time approaches</strong>: Forward-time simulation methods evolve a population forward in time, subject to arbitrary genetic and demographic factors <span class="citation">[3]</span>. Several algorithms are available, many of which allow customisation by building the simulation scheme in R or python, hence the output format of the genotypes can be specified by the user. PhenotypeSimulator offers reading genotypes from delimited-files and as such, any genotypes generated by these programme