on and loss of heterozygosity at the subclonal level for both WGS and WXS data in tumors compared to matched normals. It accounts for mixtures of cell populations and estimates the proportion of cells harboring each event. The Ha lab has developed a <a href="https://github.com/gavinha/TitanCNA/tree/master/scripts/snakemake">snakemake pipeline</a> to more easily use this tool. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216928/">Ha et al. published a paper describing this tool in detail here</a><