/Matrix/man/colSums.html" class="external-link">colMeans</a></span><span class="op">(</span><span class="va">dat</span><span class="op">)</span> <span class="op">)</span> <span class="op">)</span></span>
<span><span class="co"># equality constraint of parameters and definition of lower bounds</span></span>
<span><span class="va">partable1</span> <span class="op">&lt;-</span> <span class="fu">sirt</span><span class="fu">::</span><span class="fu">xxirt_modifyParTable</span><span class="op">(</span> <span clas