4th step.</p>
  </div>
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    <h2>Problems are Simple, but Scale is Large</h2>
    <ol>
        <li>A single run generates millions of reads.</li>
        <li>Typical file is 1~10GiB (compressed!).</li>
        <li>A genome can have giga basepairs.</li>
        <li>In many problems, we have multiple genomes, many read files (hundreds, now growing to thousands).</li>
        <li>OTOH, most of the computations are <em>embarrassingly parallel</em>.</li>
    </ol>
  </div>

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