tcome
is caries increment, as measured by the change in decayed, missing, and filled tooth surfaces
(DMFS) in the permanent dentition of children. Data that are available for study i include the
mean caries increment in trial i arm k, y ik, the number of patients at risk in each trial arm, n ik,
the time that individuals are at risk in arm k of study i, t i (measured as the trial follow-up
time, which is the same for both arms) and the interventions being compared." />
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