l2">
<h2>Coverage</h2>
<p>In high-throughput sequencing, coverage is the number of reads overlapping each base. In other words, it associates a number (the number of reads) to every base in the genome.</p>
<p>This is a fundamental quantity for many high-throughout sequencing analyses. For variant calling (DNA sequencing) it tells you how much power (information) you have to call a variant at a given location. For ChIP sequencing it is the primary signal; areas with high coverage are thought to be enriched f