ters within the mesh.</p><h2 id=multicluster-istio-setup>Multicluster Istio setup</h2><p>Follow the <a href=/v1.21/docs/setup/install/multicluster/>multicluster installation</a> section to set up your Istio clusters in one of the
supported <a href=/v1.21/docs/ops/deployment/deployment-models/#multiple-clusters>multicluster deployment models</a>. For the purpose of
this guide, any of those approaches will work, with the following caveat:</p><p><strong>Ensure that a cluster-local Istio Prometheus instance is 