a cells, and neurons. These channels provide a link 
between the electrical activity of cell membranes and cellular 
metabolism. We investigated the effects of higher extracellular 
glucose on hippocampal K(ATP) channel activities and neuronal 
excitability. The cell-attached patch-clamp configuration on 
cultured hippocampal cells and a novel multielectrode recording 
system on hippocampal slices were employed. In addition, a 
simulation modeling hippocampal CA3 pyramidal neurons (Pinsky-Rinzel 
model) was