s the alpha spending approach by Lan-DeMets (1994) &lt;doi:10.1002/sim.4780131308&gt;.">
<meta property="og:image" content="https://github.com/rpahl/GroupSeq/logo.png">
</head>
<body>
    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>


    <nav class="navbar navbar-expand-lg fixed-top bg-primary" data-bs-theme="dark" aria-label="Site navigation"><div class="container">

    <a class="navbar-brand me-2" href="index.html">GroupSeq</a>

    <small class="nav-text text-muted me-auto" da