 phase III trials are performed. Depending
on their success, the decision for a third phase III trial is made:
If both trials are successful, no third phase III trial will be conducted.
If only one of the two trials is successful and the other trial has a treatment effect that points in the same direction,
a third phase III trial will be conducted with a sample size of N3 = N3(ymin), which depends on an assumed minimal clinical relevant effect (ymin).
The third trial then has to be significant at level alph