n  title="" class="an ">&ensp;</span>mean <span  title="" class="an ">&ensp;</span>S <span  title="" class="an ">&ensp;</span>E <span  title="" class="an ">&ensp;</span>M <span  title="" class="an ">&ensp;</span>In <span  title="" class="an ">&ensp;</span>contrast <span  title="" class="an ">&ensp;</span><span  title="CAP" class="an CAP">HT</span><span  title="" class="an ">&ensp;</span>had <span  title="" class="an ">&ensp;</span>no <span  title="" class="an ">&ensp;</span>effect <span  title="" class="an 