an>, <span class='fl'>10.0</span>),
                    <span class='kw'>efficacy_hurdle</span> <span class='kw'>=</span> <span class='fl'>0.5</span>, <span class='kw'>toxicity_hurdle</span> <span class='kw'>=</span> <span class='fl'>0.3</span>,
                    <span class='kw'>p_e</span> <span class='kw'>=</span> <span class='fl'>0.1</span>, <span class='kw'>p_t</span> <span class='kw'>=</span> <span class='fl'>0.1</span>,
                    <span class='kw'>eff0</span> <span class='kw'>=</span> <span