luding tutorials.</li>
<li>
<a href="https://CRAN.R-project.org/package=rpact" class="external-link">rpact</a> also with a free <a href="https://rpact.shinyapps.io/public" class="external-link">shiny web interface</a> and lots of <a href="https://www.rpact.com/vignettes" class="external-link">vignettes</a>.</li>
</ul>
<hr>
<div id="refs" class="references csl-bib-body hanging-indent" entry-spacing="0">
<div id="ref-pmid7973215" class="csl-entry">
DeMets, D. L., and K. K. Lan. 1994. “<span class="nocase">I