Midwestern United States
Manufacturing

Navigable terrain, waterways, and ports spurred an unprecedented construction of transportation infrastructure throughout the region. The region is a global leader in advanced manufacturing and research and development, with significant innovations in both production processes and business organization. John D. Rockefeller 's Standard Oil set precedents for centralized pricing, uniform distribution, and controlled product standards through Standard Oil, which started as a consolidated refinery in Cleveland. Cyrus McCormick 's Reaper and other manufacturers of agricultural machinery consolidated into International Harvester in Chicago. Andrew Carnegie 's steel production integrated large-scale open-hearth and Bessemer processes into the world's most efficient and profitable mills. The largest, most comprehensive monopoly in the world, United States Steel, consolidated steel production throughout the region. Many of the world's largest employers began in the Great Lakes region.

Advantages of accessible waterways, highly developed transportation infrastructure, finance, and a prosperous market base makes the region the global leader in automobile production and a global business location. Henry Ford 's movable assembly line and integrated production set the model and standard for major car manufactures. The Detroit area emerged as the world's automotive center, with facilities throughout the region. Akron, Ohio became the global leader in rubber production, driven by the demand for tires. Over 200 million tons of cargo are shipped annually through the Great Lakes.
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