Diagnosis of tuberculosis
Transcriptomic host response, polygenic risk score

In 2022, a study reported the use of a fingerstick blood point-of-care triage test by Cepheid (company) looking for messenger RNA (mRNA) expression of 3 genes in response to TB. The Xpert MTB Host Response test calculated a polygenic risk score based on the expression levels of guanylate-binding protein 5, dual-specificity phosphatase 3, and Krüppel-like factor 2 genes to differentiate between active TB and other diseases.
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