Major League Baseball
Performance-enhancing drugs

In 1998, both Mark McGwire and Sammy Sosa hit more home runs than the record of 61 set by Yankees right fielder Roger Maris in 1961. Barry Bonds topped the record in 2001 with 73 home runs. McGwire, Bonds, and Sosa became the subjects of speculation regarding the use of performance-enhancing substances. McGwire later admitted that he used a steroid hormone that was still legal in baseball during the 1998 season. Baseball's original steroid testing policy, in effect from 2002 to 2005, provided for penalties ranging from a ten-game suspension for a first positive test to a one-year suspension for a fourth positive test. Players were tested at least once per year, with the chance that several players could be tested many times per year.

A 2006 book, Game of Shadows by San Francisco Chronicle investigative reporters Lance Williams and Mark Fainaru-Wada, chronicled alleged extensive use of performance enhancers, including several types of steroids and growth hormone by baseball superstars Barry Bonds, Gary Sheffield, and Jason Giambi. Former Senate Majority Leader George Mitchell was appointed by Selig on March 30, 2006 to investigate the use of performance-enhancing drugs in MLB. The appointment was made after several influential members of the U.S. Congress made negative comments about both the effectiveness and honesty of MLB's drug policies and Commissioner Selig.

The day before the Mitchell Report was to be released in 2007, Selig said, "I haven't seen the report yet, but I'm proud I did it." The report said that after mandatory random testing began in 2004, HGH treatment for athletic enhancement became popular among players, as HGH is not detectable in tests. It pointed out that HGH is likely a placebo with no performance-enhancing effects. The report included substance use allegations against at least one player from each MLB team.

According to ESPN, some people questioned whether Mitchell's director role with the Boston Red Sox created a conflict of interest, especially because no "prime players were in the report". The report named several prominent Yankees who were parts of World Series clubs; there is a long-running and fierce Yankees–Red Sox rivalry. Former U.S. prosecutor John M. Dowd brought up Mitchell's conflict of interest, but he later said that the former senator had done a good job. Mitchell acknowledged that his "tight relationship with Major League Baseball left him open to criticism", but he said that readers who examine the report closely "will not find any evidence of bias, of special treatment of the Red Sox".

On January 10, 2013, MLB and the players union reached an agreement to add random, in-season HGH testing. They also agreed to implement a new test to reveal the use of testosterone for the 2013 season. The current MLB drug policy provides for an 80-game suspension for a first positive test, a 162-game suspension for a second positive test, and a lifetime suspension for a third positive test. In 2009, allegations surfaced against Alex Rodriguez and David Ortiz, and Manny Ramirez received a 50-game suspension after testing positive for banned substances. In early April 2011, Ramirez retired from baseball rather than face a 100-game suspension for his second positive steroid test. He would later unretire, having the suspension dropped to 50 games, and would serve those in 2012.
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