Migraine
Cause

The underlying causes of migraines are unknown. However, they are believed to be related to a mix of environmental and genetic factors. They run in families in about two-thirds of cases and rarely occur due to a single gene defect. While migraines were once believed to be more common in those of high intelligence, this does not appear to be true. A number of psychological conditions are associated, including depression, anxiety, and bipolar disorder.

Success of the surgical migraine treatment by decompression of extracranial sensory nerves adjacent to vessels suggests that migraineurs may have anatomical predisposition for neurovascular compression that may be caused by both intracranial and extracranial vasodilation due to migraine triggers. This, along with the existence of numerous cranial neural interconnections, may explain the multiple cranial nerve involvement and consequent diversity of migraine symptoms.
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