Hypericum
Traditional medicine and adverse effects

Common St. John's-wort (H. perforatum) has long been used in traditional medicine as an extract to treat depression. H. perforatum is the most commonly used species – especially in Europe – as an herbal substitute for prescription drugs to treat depression, and is also sold as a dietary supplement. One meta-analysis found that St John's wort had similar efficacy and safety as prescriptions drugs to treat mild-to-moderate depression, such as selective serotonin reuptake inhibitors.

There is evidence that combining St. John’s wort with prescription antidepressants may cause adverse effects, such as a life-threatening increase of serotonin, the brain chemical targeted by some drugs used for depression. Symptoms may include agitation, diarrhea, high blood pressure, and hallucinations. Taking St. John’s wort may interfere with and reduce the efficacy of prescription drugs used to treat depression.

St. John's wort interacts with hormonal contraceptives, reducing their effectiveness and increasing the risk of unplanned pregnancy.
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