Crustacean
DNA repair

In an effort to understand whether DNA repair processes can protect crustaceans against DNA damage, basic research was conducted to elucidate the repair mechanisms used by Penaeus monodon (black tiger shrimp). Repair of DNA double-strand breaks was found to be predominantly carried out by accurate homologous recombinational repair. Another, less accurate process, microhomology-mediated end joining, is also used to repair such breaks. The expression pattern of DNA repair related and DNA damage response genes in the intertidal copepod Tigriopus japonicus was analyzed after ultraviolet irradiation. This study revealed increased expression of proteins associated with the DNA repair processes of non-homologous end joining, homologous recombination, base excision repair and DNA mismatch repair.
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