Feminine hygiene
The vulvovaginal area

The vulva acts as the initial defense line, shielding the genital tract from infections. Often, contaminants accumulate in the folds of the vulva, and factors like increased moisture, sweating, menstruation, and hormonal fluctuations can impact the growth and balance of microbial species, potentially leading to odor and vulvovaginal infections.

Distinct from other skin areas, vulvar skin exhibits variations in hydration, friction, permeability, and visible irritation. It is more susceptible to topical agents compared to forearm skin due to increased hydration, occlusion, and friction. The non-keratinized vulvar vestibule is likely more permeable than keratinized skin. Notably, genital skin is unique with a thin stratum corneum and large hair follicles, making it easier for microbes and substances to permeate.

The vagina, a fibromuscular canal extending from its external opening in the vulva to the cervix, is primarily composed of smooth muscle covered by a non-keratinized epithelial lining. This lining, until menopause, remains thick, kept moist by fluid from the vaginal wall and mucus from cervical and vestibular glands.
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