Vasco da Gama
Third voyage and death

After the death of King Manuel I in late 1521, his son and successor, King John III of Portugal set about reviewing the Portuguese government overseas. Turning away from the old Albuquerque clique (now represented by Diogo Lopes de Sequeira), John III looked for a fresh start. Vasco da Gama re-emerged from his political wilderness as an important adviser to the new king's appointments and strategy. Seeing the new Spanish threat to the Maluku Islands as the priority, Vasco da Gama advised against the obsession with Arabia that had pervaded much of the Manueline period, and continued to be the dominant concern of Duarte de Menezes, then- governor of Portuguese India. Menezes also turned out to be incompetent and corrupt, subject to numerous complaints. As a result, John III decided to appoint Vasco da Gama himself to replace Menezes, confident that the magic of his name and memory of his deeds might better impress his authority on Portuguese India, and manage the transition to a new government and new strategy.

By his appointment letter of February 1524, John III granted Vasco da Gama the privileged title of " Viceroy ", being only the second Portuguese governor to enjoy that title (the first was Francisco de Almeida in 1505). His second son, Estêvão da Gama was simultaneously appointed Capitão-mor do Mar da Índia ('Captain-major of the Indian Sea', commander of the Indian Ocean naval patrol fleet), to replace Duarte's brother, Luís de Menezes. As a final condition, Gama secured from John III of Portugal the commitment to appoint all his sons successively as Portuguese captains of Malacca.

Setting out in April 1524, with a fleet of fourteen ships, Vasco da Gama took as his flagship the famous large carrack Santa Catarina do Monte Sinai on her last journey to India, along with two of his sons, Estêvão and Paulo.
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