Gene therapy
2023

In May 2023, the FDA approved beremagene geperpavec for the treatment of wounds in people with dystrophic epidermolysis bullosa (DEB) which is applied as a topical gel that delivers a herpes-simplex virus type 1 (HSV-1) vector encoding the collagen type VII alpha 1 chain (COL7A1) gene that is dysfunctional on those affected by DEB. One trial found 65% of the Vyjuvek-treated wounds completely closed while only 26% of the placebo-treated at 24 weeks. It has been also reported its use as an eyedrop for a patient with DEB that had vision loss due to the widespread blistering with good results.
change_case:capital_word_frequency[3], oulipo:avoid_letter[a]