Frederick II, Holy Roman Emperor
Law reforms

His 1241 Edict of Salerno (sometimes called "Constitution of Salerno") made the first legally fixed separation of the occupations of physician and apothecary. Physicians were forbidden to double as pharmacists and the prices of various medicinal remedies were fixed. This became a model for regulation of the practice of pharmacy throughout Europe.

He was not able to extend his legal reforms beyond Sicily to the Empire. In 1232, he was forced by the German princes to promulgate the Statutum in favorem principum ("statute in favor of princes"). It was a charter of liberties for the leading German princes at the expense of the lesser nobility and the entirety of the commoners. The princes gained whole power of jurisdiction, and the power to strike their own coins. The emperor lost his right to establish new cities, castles and mints over their territories. The Statutum severely weakened central authority in Germany. From 1232 the vassals of the emperor had a veto over imperial legislative decisions. Every new law established by the emperor had to be approved by the princes.
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