Antihistamine
H -antihistamines

An H -antihistamine is a classification of drugs used to inhibit the action of histamine at the H receptor. H receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine. Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H receptors in the cerebral cortex. Consequently, unlike the H -antihistamines which are sedating, H -antihistamines have stimulant and cognition-modulating effects.
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