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The trombone (German: Posaune, Italian, French: trombone) is a musical instrument in the brass family. As with all brass instruments, sound is produced when the player's vibrating lips cause the air column inside the instrument to vibrate. Nearly all trombones use a telescoping slide mechanism to alter the pitch instead of the valves used by other brass instruments. The valve trombone is an exception, using three valves similar to those on a trumpet, and the superbone has valves and a slide.

The word "trombone" derives from Italian tromba (trumpet) and -one (a suffix meaning "large"), so the name means "large trumpet". The trombone has a predominantly cylindrical bore like the trumpet, in contrast to the more conical brass instruments like the cornet, the flugelhorn, the baritone, and the euphonium. The most frequently encountered trombones are the tenor trombone and bass trombone. These are treated as non-transposing instruments, reading at concert pitch in bass clef, with higher notes sometimes being notated in tenor clef. They are pitched in B♭, an octave below the B♭ trumpet and an octave above the B♭ bass tuba. The once common E♭ alto trombone became less common as improvements in technique extended the upper range of the tenor, but it is regaining popularity for its lighter sonority. In British brass-band music the tenor trombone is treated as a B♭ transposing instrument, written in treble clef, and the alto trombone is written at concert pitch, usually in alto clef.

A person who plays the trombone is called a trombonist or trombone player.