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In the Holy Roman Empire, the Great Interregnum was a period of time, from 1246 until 1273, following the throne dispute of Frederick II where the succession of the Holy Roman Empire was contested and fought over between pro- and anti-Hohenstaufen factions. Starting around 1250 with the death of Frederick II, the conflict over who was the rightful emperor and King of the Romans would continue into the 1300s until Charles IV of Luxembourg was elected emperor and secured succession for his son Wenceslaus. This period saw a multitude of emperors and kings be elected or propped up by rival factions and princes, with many kings and emperors having short reigns or reigns that became heavily contested by rival claimants. The long-lasting effects of the Interregnum were primarily the end of centralization of the imperial monarchy and the fragmentation of power towards the princes and prince-electors. The efforts of the Houses of Welf and Hohenstaufen towards expanding the power of the emperor and ensuring a clear line of succession between family members was difficult in this period, with many elections going from one family to another family in a deliberate effort by the electors to prevent a consolidation of power.