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Before the Second World War

International law has prohibited the use of chemical weapons since 1899, under the Hague Convention: Article 23 of the Regulations Respecting the Laws and Customs of War on Land adopted by the First Hague Conference "especially" prohibited employing "poison and poisoned arms". A separate declaration stated that in any war between signatory powers, the parties would abstain from using projectiles "the object of which is the diffusion of asphyxiating or deleterious gases".

The Washington Naval Treaty, signed February 6, 1922, also known as the Five-Power Treaty, aimed at banning chemical warfare but did not succeed because France rejected it. The subsequent failure to include chemical warfare has contributed to the resultant increase in stockpiles.

The Geneva Protocol, officially known as the Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous or other Gases, and of Bacteriological Methods of Warfare, is an International treaty prohibiting the use of chemical and biological weapons in international armed conflicts. It was signed at Geneva June 17, 1925, and entered into force on February 8, 1928. 133 nations are listed as state parties to the treaty. Ukraine is the newest signatory, acceding August 7, 2003.

This treaty states that chemical and biological weapons are "justly condemned by the general opinion of the civilised world". And while the treaty prohibits the use of chemical and biological weapons, it does not address the production, storage, or transfer of these weapons. Treaties that followed the Geneva Protocol did address those omissions and have been enacted.