quality:correction, quality:corruption
Americas

From his maternal grandmother, Isabella I of Castile, who had funded Christopher Columbus 's first voyage in 1492, Charles inherited Castile's overseas territories in the Americas. Spanish colonization of the Americas began in 1493, but these permanent settlements in the Caribbean and Spanish Main were marginal to Charles's European empire and not the focus of his attention. Through the Treaty of Tordesillas (1494), Spain and Portugal had agreed on a division of overseas territories, so that with the exception of Brazil, which Portugal could claim, Charles could claim the rest of the New World.

The realm of his known possessions expanded with the Spanish conquest of the Aztec Empire (1519–21) under conquistador Hernán Cortés and by Magellan's circumnavigation of the globe in 1522. These successes convinced Charles of his divine mission to become the leader of Christendom, which still perceived a significant threat from Islam. The conquest of central Mexico, bringing a high indigenous civilization under Spanish rule, compelled Charles to grapple with creating structures of institutional rule in the Americas. Charles had begun creating councils to oversee aspects of his realms, first reorganizing the existing Council of Castile, established by the Catholic Monarchs. Indicating the Americas' importance, he founded the Council of the Indies in 1524 to deal with the complexities of Castile's overseas possessions.

Unlike his European possessions that were not consolidated geographically but were nonetheless all relatively near each other, ruling the Americas had to take into account the Atlantic Ocean. Prior to the creation of the viceroyalties, he established a high court audiencia to administer justice. He formalized conversion of indigenous populations to Christianity, the so-called "spiritual conquest", by sending Franciscan, Dominican, and Augustinian friars starting in the mid-1520s. With the discovery of large deposits of silver in northern Mexico in the 1540s and in 1545 in Peru at Potosí, Charles's advisors urged regulation of mining to ensure that bullion was directed to crown coffers.

Ad hoc administrative solutions of the early conquest period gave way to Charles's establishment of the Viceroyalty of New Spain in Mexico City (1535), the Spanish capital founded on the ruins of the Aztec capital of Tenochtitlan. After the Spanish conquest of the Inca Empire in the 1530s, Charles established the Viceroyalty of Peru in the newly founded Spanish capital of Lima (1544). As it became clear that establishing royal control was important, Charles sought to undermine growing power of the group of conquistadors in Mexico and Peru, awarded personal grants of indigenous labor in perpetuity, by issuing the New Laws of 1542, ending grant holders' rights in perpetuity. Dominican friar Bartolomé de las Casas 's long term campaign to protect indigenous populations from Spanish conquerors' exploitation influenced Charles's new policy. In Peru, it resulted in a major Spanish rebellion against the crown when the newly appointed viceroy, Blasco Núñez Vela, attempted to implement the measure. In Mexico, Viceroy don Antonio de Mendoza prudently did not. In Peru, the new viceroy was murdered. "To many Spanish settlers the New Laws seemed like a declaration of war, and their hostile reaction was swift and overwhelming." The violent uprising necessitated a major military response, organized by Pedro de la Gasca, to whom Charles granted sweeping powers in order to re-establish royal authority. The rebellion in Peru coincided with one in Germany. In the Americas, Charles was forced to temper the initial order ending inheritance, allowing grants to be passed on to one further generation, but he refused to yield on the question of allowing enslavement of the indigenous.

Regarding the Spanish rebels supporting the cause of Gonzalo Pizarro, who might have set up a kingdom of Peru with himself as ruler, Charles fully supported Pizarro's beheading and his supporters' execution and confiscation of property. This was similar to the treatment of comunero rebels early in his Iberian rule. Pizarro's execution marks the end of Spanish rebellion against the crown. Relatively early in his rule, Charles assigned a concession (1528) in Venezuela Province to Bartholomeus V. Welser, in compensation for his inability to repay debts owed. The concession, known as Klein-Venedig (little Venice), was revoked in 1546 during the rebellion in Peru by Spanish colonists against Charles.

The question of labor and treatment of indigenous populations had occupied Charles's maternal grandparents, and as indigenous populations in the Caribbean were decimated by disease and overwork, transshipment of African slaves to replace the labor force began. On 28 August 1518, Charles issued a charter authorizing the transportation of slaves directly from Africa to the Americas. Up until that point (since at least 1510), African slaves had usually been transported to Castile or Portugal and had then been transshipped to the Caribbean. Charles's decision to create a direct, more economically viable Africa to America slave trade fundamentally changed the nature and scale of the transatlantic slave trade.

Protection of indigenous populations against Spaniards' exploitation was the key motivation behind Charles's issuance of the 1542 New Laws. With Gasca's suppression of Spanish colonists' rebellion in Peru, Charles was still concerned about the welfare of his indigenous subjects. So, on 3 July 1549, Charles ordered the Council of the Indies to stop all the conquests until it was certain that Spain was acting in accordance with the moral law, so penetration into the American continent was suspended until 1556. This was because philosophical questions arose, especially from Catholic jurists and scholastic philosophers, about whether the Hispanic Monarchy had the moral right to legally conquer the Indies.

Since the year 1542, a moral crisis was developing in the government because of the Spanish colonization in America, while the Crown of Castile was overwhelmed by the constant denunciations of abuses it was receiving, especially from the conquests in Peru and those that occurred in the New Kingdom of Granada, which could cause anguish in people of all Estates, even if they were prelates or knights of the Spanish nobility. Thus, Charles, influenced by the reflections of Francisco de Vitoria and the School of Salamanca, together with the pressure of missionaries, wanted to be sure that their power was beyond reproach. Therefore, it was ordered to stop all military companies in the overseas domains until a board of wise men ruled on the fairest way to carry them out, seriously considering the total or partial abandonment of the New World until the imperial doubt was resolved, regarding how to avoid in the future the possibility of abusive discoveries, overwhelming conquests and predatory colonizations that were based on the oppressive exploitation of indigenous labor.

In 1550, Charles convened a conference at Valladolid in order to consider the morality of the force used against the indigenous populations of the New World, which included figures such as Bartolomé de las Casas, from which conceptions of the human rights of the Indians would arise according to the Thomistic natural law, making the Hispanic Monarchy a pioneer, both in theory and in practice, on how to approach respect for the conquered. Theologians and jurists from all parts of the empire began to arrive in the capital, presenting themselves with the best souls of Spain, such as Domingo de Soto, Bartolomé Carranza, Melchor Cano, and also Pedro de la Gasca (Peru's first peacemaker after Civil Wars between the conquerors of Peru) together with the jurisconsults of the Council of the Indies. Bartolomé de las Casas would defend that the wars of conquest were unjust, while Juan Ginés de Sepúlveda would defend the opposite. The court, after long debates, voted and tied, so there was no official sentence, but there were several binding reports in which the purpose was to ensure that the treatment given to the natives was correct. It was the first time that kings and philosophers conceded that men have fundamental rights for the mere fact of being men (Ius gentium), rights of the eternal Law that are prior to any positive law written in the treaties. Never before had a European people wondered in such depth where their own rights of the victor ended, and where the rights of the defeated begin.

Finally, Spain did not abandon the Indies, largely based on the sayings of Vitoria: "After many barbarians have converted there, it would not be convenient or lawful for the prince to abandon the administration of those provinces." Therefore, Spanish rule was maintained as Sepúlveda claimed, but it was recognized that the Indians were people with their own rights as de las Casas paid for and enshrined in the New Laws, together with the papal bull Sublimis Deus. Given this, there was no longer talks about conquest, but about pacification, so urbanization was resumed, with specific instructions to avoid harm to the Indians. The regulations on how to act in the future, in terms of discoveries and colonizations, were the following:

-In the discoveries: They would be made with a license from the Audiencia and carrying at least one religious designated by it. On these trips it was forbidden to steal the goods from the natives and take them by force, except for some of them who wanted to go as interpreters. No Viceroy or Governor would undertake new voyages of discovery on their own. Neither by sea nor by land.-In the colonizations: parcels would be prohibited from the first life; Indian slaves would be freed (it was forbidden to make them slaves in the future); a revision of the repartimientos de indios (to the Audiencias) would be ordered so that those that some Spaniards had in excess would pass to the Crown; All the Indians that private individuals had without legitimate title would be transferred to the Crown; it would be forbidden to charge the natives (except where it was inexcusable); moderate rates would be imposed on taxes and services; Rates and tributes would be completely abolished in those places where the Indians had been subjected to fierce exploitation (The Antilles).