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Ancient antiquity

Since approximately 10,000 BC, Syria was one of the centers of Neolithic culture (known as Pre-Pottery Neolithic A), where agriculture and cattle breeding first began to appear. The Neolithic period (PPNB) is represented by rectangular houses of Mureybet culture. At the time of the pre-pottery Neolithic, people used containers made of stone, gyps and burnt lime (Vaisselle blanche). The discovery of obsidian tools from Anatolia are evidence of early trade. The ancient cities of Hamoukar and Emar played an important role during the late Neolithic and Bronze Age. Archaeologists have demonstrated that civilization in Syria was one of the most ancient on earth, perhaps preceded by only that of Mesopotamia.

The earliest recorded indigenous civilization in the region was the Kingdom of Ebla near present-day Idlib, northern Syria. Ebla appears to have been founded around 3500 BC, and gradually built its fortune through trade with the Mesopotamian states of Sumer, Assyria, and Akkad, as well as with the Hurrian and Hattian peoples to the northwest, in Asia Minor. Gifts from Pharaohs, found during excavations, confirm Ebla's contact with Egypt. One of the earliest written texts from Syria is a trading agreement between Vizier Ibrium of Ebla and an ambiguous kingdom called Abarsal c. 2300 BC. Scholars believe the language of Ebla to be among the oldest known written Semitic languages after Akkadian. Recent classifications of the Eblaite language have shown that it was an East Semitic language, closely related to the Akkadian language. Ebla was weakened by a long war with Mari, and the whole of Syria became part of the Mesopotamian Akkadian Empire after Sargon of Akkad and his grandson Naram-Sin 's conquests ended Eblan domination over Syria in the first half of the 23rd century BC.

By the 21st century BC, Hurrians settled the northern east parts of Syria while the rest of the region was dominated by the Amorites. Syria was called the Land of the Amurru (Amorites) by their Assyro-Babylonian neighbors. The Northwest Semitic language of the Amorites is the earliest attested of the Canaanite languages. Mari reemerged during this period, and saw renewed prosperity until conquered by Hammurabi of Babylon. Ugarit also arose during this time, circa 1800 BC, close to modern Latakia. Ugaritic was a Semitic language loosely related to the Canaanite languages, and developed the Ugaritic alphabet, considered to be the world's earliest known alphabet. The Ugaritic kingdom survived until its destruction at the hands of the marauding Indo-European Sea Peoples in the 12th century BC in what was known as the Late Bronze Age Collapse which saw similar kingdoms and states witness the same destruction at the hand of the Sea Peoples.

Aleppo and the capital city Damascus are among the oldest continuously inhabited cities in the world. Yamhad (modern Aleppo) dominated northern Syria for two centuries, although Eastern Syria was occupied in the 19th and 18th centuries BC by the Old Assyrian Empire ruled by the Amorite Dynasty of Shamshi-Adad I, and by the Babylonian Empire which was founded by Amorites. Yamhad was described in the tablets of Mari as the mightiest state in the near east and as having more vassals than Hammurabi of Babylon. Yamhad imposed its authority over Alalakh, Qatna, the Hurrians states and the Euphrates Valley down to the borders with Babylon. The army of Yamhad campaigned as far away as Dēr on the border of Elam (modern Iran). Yamhad was conquered and destroyed, along with Ebla, by the Indo-European Hittites from Asia Minor circa 1600 BC. From this time, Syria became a battle ground for various foreign empires, these being the Hittite Empire, Mitanni Empire, Egyptian Empire, Middle Assyrian Empire, and to a lesser degree Babylonia. The Egyptians initially occupied much of the south, while the Hittites, and the Mitanni, much of the north. However, Assyria eventually gained the upper hand, destroying the Mitanni Empire and annexing huge swathes of territory previously held by the Hittites and Babylon.

Around the 14th century BC, various Semitic peoples appeared in the area, such as the semi-nomadic Suteans who came into an unsuccessful conflict with Babylonia to the east, and the West Semitic speaking Arameans who subsumed the earlier Amorites. They too were subjugated by Assyria and the Hittites for centuries. The Egyptians fought the Hittites for control over western Syria; the fighting reached its zenith in 1274 BC with the Battle of Kadesh. The west remained part of the Hittite empire until its destruction c. 1200 BC, while eastern Syria largely became part of the Middle Assyrian Empire, who also annexed much of the west during the reign of Tiglath-Pileser I 1114–1076 BC. With the destruction of the Hittites and the decline of Assyria in the late 11th century BC, the Aramean tribes gained control of much of the interior, founding states such as Bit Bahiani, Aram-Damascus, Hamath, Aram-Rehob, Aram-Naharaim, and Luhuti. From this point, the region became known as Aramea or Aram. There was also a synthesis between the Semitic Arameans and the remnants of the Indo-European Hittites, with the founding of a number of Syro-Hittite states centered in north central Aram (Syria) and south central Asia Minor (modern Turkey), including Palistin, Carchemish and Sam'al.

A Canaanite group known as the Phoenicians came to dominate the coasts of Syria, (and also Lebanon and northern Palestine) from the 13th century BC, founding city states such as Amrit, Simyra, Arwad, Paltos, Ramitha and Shuksi. From these coastal regions, they eventually spread their influence throughout the Mediterranean, including building colonies in Malta, Sicily, the Iberian peninsula (modern Spain and Portugal), and the coasts of North Africa and most significantly, founding the major city state of Carthage (in modern Tunisia) in the 9th century BC, which was much later to become the center of a major empire, rivaling the Roman Republic. Syria and the Western half of Near East then fell to the vast Neo Assyrian Empire (911 BC – 605 BC). The Assyrians introduced Imperial Aramaic as the lingua franca of their empire. This language was to remain dominant in Syria and the entire Near East until after the Arab Islamic conquest in the 7th and 8th centuries AD, and was to be a vehicle for the spread of Christianity. The Assyrians named their colonies of Syria and Lebanon Eber-Nari. Assyrian domination ended after the Assyrians greatly weakened themselves in a series of brutal internal civil wars, followed by attacks from: the Medes, Babylonians, Chaldeans, Persians, Scythians and Cimmerians. During the fall of Assyria, the Scythians ravaged and plundered much of Syria. The last stand of the Assyrian army was at Carchemish in northern Syria in 605 BC. The Assyrian Empire was followed by the Neo-Babylonian Empire (605 BC – 539 BC). During this period, Syria became a battle ground between Babylonia and another former Assyrian colony, that of Egypt. The Babylonians, like their Assyrian relations, were victorious over Egypt.