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Cities and regions

While the Mojave Desert is generally sparsely populated, it has increasingly become urbanized in recent years. The metropolitan areas include Las Vegas, the largest urban area in the Mojave and the largest urban area in Nevada with a population of about 2.3 million. St. George, Utah, is the northeasternmost metropolitan area in the Mojave, with a population of around 180,000 in 2020, and is located at the convergence of the Mojave, Great Basin, and Colorado Plateau. The Los Angeles exurban area of Lancaster - Palmdale has more than 400,000 residents, and the Victorville area to its east has more than 300,000 residents. Smaller cities or micropolitan areas in the Mojave Desert include Helendale, Lake Havasu City, Kingman, Laughlin, Bullhead City and Pahrump. All have experienced rapid population growth since 1990. The California portion of the desert also contains Edwards Air Force Base and Naval Air Weapons Station China Lake, noted for experimental aviation and weapons projects.

The Mojave Desert has several ghost towns. The most significant are the silver and copper-mining town of Calico, California, and the old railroad depot of Kelso, California. Some of the other ghost towns are more modern, created when U.S. Route 66 (and the lesser-known U.S. Route 91) were abandoned in favor of the construction of Interstates. CA SR 14, Interstate 15, Interstate 40, CA SR 58, CA SR 138, US Route 95, and US Route 395 are the main highways that traverse the Mojave Desert.