quality:correction, structural:reformatting, structural:scholar_edition, linguistic:paraphrasing
Early Iron Age – Native rule, second dynasty of Isin, 1155–1026 BC

The Elamites did not remain in control of Babylonia long, instead entering into an ultimately unsuccessful war with Assyria, allowing Marduk-kabit-ahheshu (1155–1139 BC) to establish the Dynasty IV of Babylon, from Isin, with the first native Akkadian-speaking south Mesopotamian dynasty to rule Babylonia, with Marduk-kabit-ahheshu becoming only the second native Mesopotamian to sit on the throne of Babylon, after the Assyrian king Tukulti-Ninurta I. His dynasty was to remain in power for some 125 years. The new king successfully drove out the Elamites and prevented any possible Kassite revival. Later in his reign he went to war with Assyria, and had some initial success, briefly capturing the south Assyrian city of Ekallatum before ultimately suffering defeat at the hands of Ashur-Dan I.

Itti-Marduk-balatu succeeded his father in 1138 BC, and successfully repelled Elamite attacks on Babylonia during his 8-year reign. He too made attempts to attack Assyria, but also met with failure at the hands of the still reigning Ashur-Dan I.

Ninurta-nadin-shumi took the throne in 1127 BC, and also attempted an invasion of Assyria, his armies seem to have skirted through eastern Aramea (modern Syria) and then made an attempt to attack the Assyrian city of Arbela (modern Erbil) from the west. However, this bold move met with defeat at the hands of Ashur-resh-ishi I who then forced a treaty in his favour upon the Babylonian king.

Nebuchadnezzar I (1124–1103 BC) was the most famous ruler of this dynasty. He fought and defeated the Elamites and drove them from Babylonian territory, invading Elam itself, sacking the Elamite capital Susa, and recovering the sacred statue of Marduk that had been carried off from Babylon during the fall of the Kassites. Shortly afterwards, the king of Elam was assassinated and his kingdom disintegrated into civil war. However, Nebuchadnezzar failed to extend Babylonian territory further, being defeated a number of times by Ashur-resh-ishi I (1133–1115 BC), king of the Middle Assyrian Empire, for control of formerly Hittite-controlled territories in Aram and Anatolia. The Hittite Empire of the northern and western Levant and eastern Anatolia had been largely annexed by the Middle Assyrian Empire, and its heartland finally overrun by invading Phrygians from the Balkans. In the later years of his reign, Nebuchadnezzar I devoted himself to peaceful building projects and securing Babylonia's borders against the Assyrians, Elamites and Arameans.

Nebuchadnezzar was succeeded by his two sons, firstly Enlil-nadin-apli (1103–1100 BC), who lost territory to Assyria. The second of them, Marduk-nadin-ahhe (1098–1081 BC) also went to war with Assyria. Some initial success in these conflicts gave way to a catastrophic defeat at the hands of the powerful Assyrian king Tiglath-Pileser I (1115–1076 BC), who annexed huge swathes of Babylonian territory, thus further expanding the Assyrian Empire. Following this a terrible famine gripped Babylon, inviting attacks and migrations from the northwest Semitic tribes of Aramaeans and Suteans from the Levant.

In 1072 BC Marduk-shapik-zeri signed a peace treaty with Ashur-bel-kala (1075–1056 BC) of Assyria, however, his successor Kadašman-Buriaš was not so friendly to Assyria, prompting the Assyrian king to invade Babylonia and depose him, placing Adad-apla-iddina on the throne as his vassal. Assyrian domination continued until c. 1050 BC, with Marduk-ahhe-eriba and Marduk-zer-X regarded as vassals of Assyria. After 1050 BC the Middle Assyrian Empire descended into a period of civil war, followed by constant warfare with the Arameans, Phrygians, Neo-Hittite states and Hurrians, allowing Babylonia to once more largely free itself from the Assyrian yoke for a few decades.

However, East Semitic-speaking Babylonia soon began to suffer further repeated incursions from West Semitic nomadic peoples migrating from the Levant during the Bronze Age collapse, and during the 11th century BC large swathes of the Babylonian countryside was appropriated and occupied by these newly arrived Arameans and Suteans. Arameans settled much of the countryside in eastern and central Babylonia and the Suteans in the western deserts, with the weak Babylonian kings being unable to stem these migrations.