structural:summarization, quality:corruption
Autonomic

Alterations in the autonomic nervous system, known as dysautonomia, are associated with a variety of symptoms such as gastrointestinal dysfunction, orthostatic hypotension, excessive sweating, or urinary incontinence.

Gastrointestinal issues include constipation, impaired stomach emptying, immoderate production of saliva, and swallowing difficulty (prevalence up to 82 percent). Complications resulting from dysphagia include dehydration, malnutrition, weight loss, and aspiration pneumonia. All gastrointestinal features can be severe enough to cause discomfort, endanger health, and complicate disease management. Despite being related to each other, the exact mechanism of these symptoms remains unknown.

Orthostatic hypotension is the sustained drop of blood pressure by at least 20 mmHg systolic or 10 mmHg diastolic within the first three minutes after raising to an upright position that can be seen in 30–50 percent of cases. Low blood pressure can impair the perfusion of organs situated above the heart, particularly the brain, resulting in lightheadedness. This can eventually lead to fainting and is associated with higher morbidity and mortality.

Other autonomic-related symptoms include excessive sweating, urinary incontinence, and sexual dysfunction.