linguistic:translation
The blood–testis barrier

Large molecules cannot pass from the blood into the lumen of a seminiferous tubule due to the presence of tight junctions between adjacent Sertoli cells. The spermatogonia occupy the basal compartment (deep to the level of the tight junctions) and the more mature forms, such as primary and secondary spermatocytes and spermatids, occupy the adluminal compartment.

The function of the blood–testis barrier may be to prevent an auto-immune reaction. Mature sperm (and their antigens) emerge significantly after immune tolerance is set in infancy. Since sperm are antigenically different from self-tissue, a male animal can react immunologically to his own sperm. The male can make antibodies against them.

Injection of sperm antigens causes inflammation of the testis (auto-immune orchitis) and reduced fertility. The blood–testis barrier may reduce the likelihood that sperm proteins will induce an immune response.