information:classification
UBASH3B locus

UBASH3B encodes a protein with tyrosine phosphatase activity, which has been previously linked to advanced neoplasia. SNP rs7115089 was identified as influencing DNA methylation and expression of this locus, as well as and Body Mass Index (BMI). In fact, SNP rs7115089 is strongly associated with BMI and with genetic variants linked to other cardiovascular and metabolic traits in GWASs. New studies suggesting UBASH3B as a potential mediator of adiposity and cardiometabolic disease. In addition, animal models demonstrated that UBASH3B expression is an indicator of caloric restriction that may drive programmed susceptibility to obesity and it is associated with other measures of adiposity in human peripherical blood.