linguistic:translation
Native Americans

The area of the Mississippi River basin was first settled by hunting and gathering Native American peoples and is considered one of the few independent centers of plant domestication in human history. Evidence of early cultivation of sunflower, a goosefoot, a marsh elder and an indigenous squash dates to the 4th millennium BC. The lifestyle gradually became more settled after around 1000 BC during what is now called the Woodland period, with increasing evidence of shelter construction, pottery, weaving and other practices.

A network of trade routes referred to as the Hopewell interaction sphere was active along the waterways between about 200 and 500 AD, spreading common cultural practices over the entire area between the Gulf of Mexico and the Great Lakes. A period of more isolated communities followed, and agriculture introduced from Mesoamerica based on the Three Sisters (maize, beans and squash) gradually came to dominate. After around 800 AD there arose an advanced agricultural society today referred to as the Mississippian culture, with evidence of highly stratified complex chiefdoms and large population centers.

The most prominent of these, now called Cahokia, was occupied between about 600 and 1400 AD and at its peak numbered between 8,000 and 40,000 inhabitants, larger than London, England of that time. At the time of first contact with Europeans, Cahokia and many other Mississippian cities had dispersed, and archaeological finds attest to increased social stress.

Modern American Indian nations inhabiting the Mississippi basin include Cheyenne, Sioux, Ojibwe, Potawatomi, Ho-Chunk, Fox, Kickapoo, Tamaroa, Moingwena, Quapaw and Chickasaw.

The word Mississippi itself comes from Messipi, the French rendering of the Anishinaabe (Ojibwe or Algonquin) name for the river, Misi-ziibi (Great River). The Ojibwe called Lake Itasca Omashkoozo-zaaga'igan (Elk Lake) and the river flowing out of it Omashkoozo-ziibi (Elk River). After flowing into Lake Bemidji, the Ojibwe called the river Bemijigamaag-ziibi (River from the Traversing Lake). After flowing into Cass Lake, the name of the river changes to Gaa-miskwaawaakokaag-ziibi (Red Cedar River) and then out of Lake Winnibigoshish as Wiinibiigoonzhish-ziibi (Miserable Wretched Dirty Water River), Gichi-ziibi (Big River) after the confluence with the Leech Lake River, then finally as Misi-ziibi (Great River) after the confluence with the Crow Wing River. After the expeditions by Giacomo Beltrami and Henry Schoolcraft, the longest stream above the juncture of the Crow Wing River and Gichi-ziibi was named "Mississippi River". The Mississippi River Band of Chippewa Indians, known as the Gichi-ziibiwininiwag, are named after the stretch of the Mississippi River known as the Gichi-ziibi. The Cheyenne, one of the earliest inhabitants of the upper Mississippi River, called it the Máʼxe-éʼometaaʼe (Big Greasy River) in the Cheyenne language. The Arapaho name for the river is Beesniicíe. The Pawnee name is Kickaátit.

The Mississippi was spelled Mississipi or Missisipi during French Louisiana and was also known as the Rivière Saint-Louis.