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American settlement

While French control ended in 1763 after their defeat in the Seven Years' War, most of the several hundred French settlers in small villages along the Mississippi River and its tributaries remained, and were not disturbed by the new British administration. By the terms of the Treaty of Paris, Spain was given Louisiana; the area west of the Mississippi. St. Louis and Ste. Genevieve in Missouri were the main towns, but there was little new settlement. France regained Louisiana from Spain in exchange for Tuscany by the terms of the Treaty of San Ildefonso in 1800. Napoleon had lost interest in re-establishing a French colonial empire in North America following the Haitian Revolution and together with the fact that France could not effectively defend Louisiana from a possible British attack, he sold the territory to the United States in the Louisiana Purchase of 1803. Meanwhile, the British maintained forts and trading posts in U.S. territory, refusing to give them up until 1796 by the Jay Treaty. American settlement began either via routes over the Appalachian Mountains or through the waterways of the Great Lakes. Fort Pitt (now Pittsburgh) at the source of the Ohio River became the main base for settlers moving into the Midwest. Marietta, Ohio in 1787 became the first settlement in Ohio, but not until the defeat of Native American tribes at the Battle of Fallen Timbers in 1794 was large-scale settlement possible. Large numbers also came north from Kentucky into southern Ohio, Indiana and Illinois.

The region's fertile soil produced corn and vegetables; most farmers were self-sufficient. They cut trees and claimed the land, then sold it to newcomers and then moved further west to repeat the process.