structural:expansion, linguistic:translation
Epidemiology

A research over large samples has shown that levels of neuroticism are higher in women than men. Neuroticism is also found to decrease slightly with age. The same study noted that no functional MRI studies have yet been performed to investigate these differences, calling for more research. A 2010 review found personality differences between genders to be between "small and moderate", the largest of those differences being in the traits of agreeableness and neuroticism. Many personality traits were found to have had larger personality differences between men and women in developed countries compared to less developed countries, and differences in three traits—extraversion, neuroticism, and people-versus-thing orientation—showed differences that remained consistent across different levels of economic development, which is also consistent with the "possible influence of biologic factors." Three cross-cultural studies have revealed higher levels of female neuroticism across almost all nations.

A 2016 review investigated the geographic issue; it found that in US, neuroticism is highest in the mid-Atlantic states and southwards but declines westward, while openness to experience is highest in ethnically diverse regions of the mid-Atlantic, New England, the West Coast, and cities. Likewise, in the UK neuroticism is lowest in urban areas. Generally, geographical studies find correlations between low neuroticism and entrepreneurship and economic vitality and correlations between high neuroticism and poor health outcomes. The review found that the causal relationship between regional cultural and economic conditions and psychological health is unclear.

A 2013 review found that a high level of neuroticism in young adults is a risk factor for triggering mood disorders. Neuroticism is also a possible risk factor for developing an addiction disorder to internet. Investigation of the Instagram users showed the preference of cosmetic products and intolerance of weapons among highly neurotic users.

There is a strong correlation between bruxism and neuroticism. More severe bruxism is associated with a higher degree of neuroticism.