structural:summarization, information:highlighting
Ismail II (r. 1576–1577)

Ismail's 14-month reign was notable for two things: continual bloodletting of his relatives and others (including his own supporters) and his reversal on religion. He had all his relatives killed except for his older brother, Mohammad Khudabanda, who, being nearly blind, was not a real candidate for the throne, and Mohammad's three sons, Hamza Mirza, Abbas Mirza and Abu Talib Mirza. While the murderous actions of Ismail might be explained by political prudence (Ottoman sultans occasionally purged the bloodline to prevent succession rivals), his actions against Shi’a suggest retaliation against his father, who saw himself as a pious practitioner. Ismail sought to reintroduce Sunni orthodoxy. But even here there may have been practical political considerations; namely, "concern about the excessively powerful position of Shiʻi dignitaries, which would have been undermined by a reintroduction of the Sunna." His conduct might also be explained by his drug use. In any event, he was ultimately killed (according to some accounts) by his Circassian half-sister, Pari Khān Khānum, who championed him over Haydar. She is said to have poisoned his opium.