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Medici Dukes

Another outstanding figure of the 16th-century Medici family was Cosimo I, who rose from relatively modest beginnings in the Mugello to attain supremacy over the whole of Tuscany. Against the opposition of Catherine de' Medici, Pope Paul III and their allies, he prevailed in various battles to conquer Florence's hated rival Siena and found the Grand Duchy of Tuscany. Cosimo purchased a portion of the island of Elba from the Republic of Genoa and based the Tuscan navy there. He died in 1574, succeeded by his eldest surviving son Francesco, whose death without male heirs led to the succession of his younger brother, Ferdinando, in 1587. Francesco married Johanna of Austria, and with his consort produced Eleonora de' Medici, Duchess of Mantua, and Marie de' Medici, Queen of France and Navarre. Through Marie, all succeeding French monarchs (bar the Napoleons) were descended from Francesco.

Ferdinando eagerly assumed the government of Tuscany. He commanded the draining of the Tuscan marshlands, built a road network in southern Tuscany and cultivated trade in Livorno. To augment the Tuscan silk industry, he oversaw the planting of mulberry trees along the major roads (silk worms feed on mulberry leaves). In foreign affairs, he shifted Tuscany away from Habsburg hegemony by marrying the first non-Habsburg marriage candidate since Alessandro, Christina of Lorraine, a granddaughter of Catherine de' Medici. The Spanish reaction was to construct a citadel on their portion of the island of Elba. To strengthen the new Franco-Tuscan alliance, he married his niece, Marie, to Henry IV of France. Henry explicitly stated that he would defend Tuscany from Spanish aggression, but later reneged, after which Ferdinando was forced to marry his heir, Cosimo, to Maria Maddalena of Austria to assuage Spain (where Maria Maddalena's sister Margaret was the incumbent Queen consort). Ferdinando also sponsored a Tuscan expedition to the New World with the intention of establishing a Tuscan colony, an enterprise that brought no result for permanent colonial acquisitions.

Despite all of these incentives for economic growth and prosperity, the population of Florence at the dawn of the 17th century was a mere 75,000, far smaller than the other capitals of Italy (i.e., Rome, Milan, Venice, Palermo, and Naples). Francesco and Ferdinando, due to lax distinction between Medici and Tuscan state property, are thought to have been wealthier than their ancestor, Cosimo de' Medici, the founder of the dynasty. The Grand Duke alone had the prerogative to exploit the state's mineral and salt resources, and the fortunes of the Medici were directly tied to the Tuscan economy.