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Interpretation of quantum theory

The development of quantum mechanics, and the apparently contradictory implications in regard to what is "real" had profound philosophical implications, including what scientific observations truly mean. In contrast to Albert Einstein and Louis de Broglie, who were realists who believed that particles had an objectively true momentum and position at all times (even if both could not be measured), Heisenberg was an anti-realist, arguing that direct knowledge of what is "real" was beyond the scope of science. Writing in his book The Physicist's Conception of Nature, Heisenberg argued that ultimately we only can speak of the knowledge (numbers in tables) which describe something about particles but we can never have any "true" access to the particles themselves:

We can no longer speak of the behaviour of the particle independently of the process of observation. As a final consequence, the natural laws formulated mathematically in quantum theory no longer deal with the elementary particles themselves but with our knowledge of them. Nor is it any longer possible to ask whether or not these particles exist in space and time objectively...When we speak of the picture of nature in the exact science of our age, we do not mean a picture of nature so much as a picture of our relationships with nature....Science no longer confronts nature as an objective observer, but sees itself as an actor in this interplay between man and nature. The scientific method of analysing, explaining and classifying has become conscious of its limitations, which arise out of the fact that by its intervention science alters and refashions the object of investigation. In other words, method and object can no longer be separated.