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Establishment of the Holy Office of the Inquisition

Torquemada deeply suspected the Marrano and Morisco as a menace to Spain's welfare by both their increasing religious influence and their economic power in Spain. The Crown of Aragon had Dominican inquisitors almost continuously throughout much of the 14th and the 15th centuries. King Ferdinand and Queen Isabella petitioned Pope Sixtus IV to grant their request for a Holy Office to administer an inquisition in Spain. The Pope granted their request and established the Holy Office for the Propagation of the Faith in late 1478.

The papal bull gave the sovereigns full powers to name inquisitors. Rome retained the right to formally appoint the royal nominees. Henry Charles Lea observed that the Spanish Inquisition in both Castile and Aragon remained firmly under Ferdinand's direction throughout the joint reign.