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Late reign and death

Shah Ismail's death ensued after a few years of a very saddening and depressing period of his life. After the Battle of Chaldiran, Ismail lost his supernatural air and the aura of invincibility, gradually falling into heavy drinking of alcohol. He retired to his palace, never again participated in a military campaign, and withdrew from active participation in the affairs of the state. He left these to his vizier, Mirza Shah Husayn, who became his close friend and drinking companion. This allowed Mirza Shah Husayn to gain influence over Ismail and expand his authority. Mirza Shah Husayn was assassinated in 1523 by a group of Qizilbash officers, after which Ismail appointed Zakariya's son Jalal al-Din Mohammad Tabrizi as his new vizier. Ismail died on 23 May 1524 at the relatively early age of 36. He was buried in Ardabil, and was succeeded by his son Tahmasp I.

The consequences of the defeat at Chaldiran were also psychological for Ismail: His relationships with his Qizilbash followers were fundamentally altered. The tribal rivalries between the Qizilbash, which temporarily ceased before the defeat at Chaldiran, resurfaced in intense form immediately after the death of Ismail, and led to ten years of civil war (930–40/1524–33) until Shah Tahmasp regained control of the affairs of the state. The Safavids later briefly lost Balkh and Kandahar to the Mughals, and nearly lost Herat to the Uzbeks.

During Ismail's reign, mainly in the late 1510s, the first steps for the Habsburg–Persian alliance were set as well, with Charles V and Ludwig II of Hungary being in contact with a view to combining against the common Ottoman Turkish enemy.