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Toxicity

Acetone occurs naturally as part of certain metabolic processes in the human body, and has been studied extensively and is believed to exhibit only slight toxicity in normal use. There is no strong evidence of chronic health effects if basic precautions are followed. It is generally recognized to have low acute and chronic toxicity if ingested and/or inhaled. Acetone is not currently regarded as a carcinogen, a mutagen, or a concern for chronic neurotoxicity effects.

Acetone can be found as an ingredient in a variety of consumer products ranging from cosmetics to processed and unprocessed foods. Acetone has been rated as a generally recognized as safe (GRAS) substance when present in drinks, baked foods, desserts, and preserves at concentrations ranging from 5 to 8 mg/L.

Acetone is however an irritant, causing mild skin and moderate-to-severe eye irritation. At high vapor concentrations, it may depress the central nervous system like many other solvents. Acute toxicity for mice by ingestion (LD) is 3 g/kg, and by inhalation (LC) is 44 g/m over 4 hours.