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Links to disease

The importance of these untranslated regions of mRNA is just beginning to be understood. Various medical studies are being conducted that have found connections between mutations in untranslated regions and increased risk for developing a particular disease, such as cancer. For example, associations between polymorphisms in the HLA-G 3′UTR region and development of colorectal cancer have been discovered. Single Nucleotide Polymorphisms in the 3' UTR of another gene have also been associated with susceptibility to preterm birth. Mutations in the 3' UTR of the APP gene are related to development of cerebral amyloid angiopathy.