stylistic:style_transfer, information:classification
History

Commercial production of HFCS began in 1964.: 17 In the late 1950s, scientists at Clinton Corn Processing Company of Clinton, Iowa, tried to turn glucose from corn starch into fructose, but the process they used was not scalable.: 17 In 1965–1970, Yoshiyuki Takasaki, at the Japanese National Institute of Advanced Industrial Science and Technology developed a heat-stable xylose isomerase enzyme from yeast. In 1967, the Clinton Corn Processing Company obtained an exclusive license to manufacture glucose isomerase derived from Streptomyces bacteria and began shipping an early version of HFCS in February 1967.: 140 In 1983, the FDA accepted HFCS as "generally recognized as safe," and that decision was reaffirmed in 1996.