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Middle Ages and modern era

During the Middle Ages, the Red Sea was an important part of the spice trade route. In 1183, Raynald of Châtillon launched a raid down the Red Sea to attack the Muslim pilgrim convoys to Mecca. The possibility that Raynald's fleet might sack the holy cities of Mecca and Medina caused fury throughout the Muslim world. However, it appears that Reynald's target was the lightly armed Muslim pilgrim convoys, rather than the well guarded cities of Mecca and Medina, and the belief in the Muslim world that Reynald was seeking to sack the holy cities, due to the proximity of those cities to the areas that Raynald raided.

In 1513, trying to secure that channel to Portugal, Afonso de Albuquerque laid siege to Aden but was forced to retreat. They cruised the Red Sea inside the Bab al-Mandab, as the first fleet from Europe in modern times to have sailed these waters. Later in 1524 the city was delivered to Governor Heitor da Silveira as an agreement for protection from the Ottomans. In 1798, France ordered General Napoleon to invade Egypt and take control of the Red Sea. Although he failed in his mission, the engineer Jean-Baptiste Lepère, who took part in it, revitalised the plan for a canal which had been envisaged during the reign of the Pharaohs. Several canals were built in ancient times from the Nile to the Red Sea along or near the line of the present Sweet Water Canal, but none lasted for long. The Suez Canal was opened in November 1869. During the first half of the 20th-century, the Red Sea slave trade attracted substantional international condemnation.

After the Second World War, the Americans and Soviets exerted their influence whilst the volume of oil tanker traffic intensified. However, the Six-Day War culminated in the closure of the Suez Canal from 1967 to 1975. Today, in spite of patrols by the major maritime fleets in the waters of the Red Sea, the Suez Canal has never recovered its supremacy over the Cape route, which is believed to be less vulnerable to piracy.

Iranian -backed Yemini Houthis have attacked Western ships, including warships, during the 2023-2024 Israel-Hamas war. One ship was hijacked and taken back to Yemen.