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Presidential succession in 1910

Díaz had ruled continuously since 1884. The question of presidential succession was an issue as early as 1900, when he turned 70. Díaz re-established the office of vice president in 1906, choosing Ramón Corral. Rather than managing political succession, Díaz marginalized Corral, keeping him away from decision-making. Díaz publicly announced in an interview with journalist James Creelman for Pearson's Magazine that he would not run in the 1910 election. At age 80, this set the scene for a possible peaceful transition in the presidency. It set off a flurry of political activity. To the dismay of potential candidates to replace him, he reversed himself and ran again. His later reversal on retiring from the presidency set off tremendous activity among opposition groups.

Díaz seems to have initially considered Finance Minister José Yves Limantour as his successor. Limantour was a key member of the Científicos, the circle of technocratic advisers steeped in positivist political science. Another potential successor was General Bernardo Reyes, Díaz's Minister of War, who also served as governor of Nuevo León. Reyes, an opponent of the Científicos, was a moderate reformer with a considerable base of support. Díaz became concerned about him as a rival and forced him to resign from his cabinet. He attempted to marginalize Reyes by sending him on a "military mission" to Europe, distancing him from Mexico and potential political supporters. "The potential challenge from Reyes would remain one of Díaz's political obsessions through the rest of the decade, which ultimately blinded him to the danger of the challenge of Francisco Madero's anti-re-electionist campaign."

In 1910, Francisco I. Madero, a young man from a wealthy landowning family in the northern state of Coahuila, announced his intent to challenge Díaz for the presidency in the next election, under the banner of the Anti-Reelectionist Party. Madero chose as his running mate Francisco Vázquez Gómez, a physician who had opposed Díaz. Madero campaigned vigorously and effectively. To ensure Madero did not win, Díaz had him jailed before the election. He escaped and fled for a short period to San Antonio, Texas. Díaz was announced the winner of the election by a "landslide".