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Skeleton

The skull of a snake differs from a lizards in several ways. Snakes have more flexible jaws, that is, instead of a juncture at the upper and lower jaw, the snake's jaws are connected by a bone hinge that is called the quadrate bone. Between the two halves of the lower jaw at the chin there is an elastic ligament that allows for a separation. This allows the snake to swallow food larger in proportion to their size and go longer without it, since snakes ingest relatively more in one feeding. Because the sides of the lower jaw can move independently of one another, a snake resting its jaw on a surface has stereo auditory perception, used for detecting the position of prey. The jaw–quadrate– stapes pathway is capable of detecting vibrations on the angstrom scale, despite the absence of an outer ear and the lack of an impedance matching mechanism—provided by the ossicles in other vertebrates. In a snake's skull the brain is well protected. As brain tissues could be damaged through the palate, this protection is especially valuable. The solid and complete neurocranium of snakes is closed at the front.

The skeleton of most snakes consists solely of the skull, hyoid, vertebral column, and ribs, though henophidian snakes retain vestiges of the pelvis and rear limbs. The hyoid is a small bone located posterior and ventral to the skull, in the 'neck' region, which serves as an attachment for the muscles of the snake's tongue, as it does in all other tetrapods. The vertebral column consists of between 200 and 400 vertebrae, or sometimes more. The body vertebrae each have two ribs articulating with them. The tail vertebrae are comparatively few in number (often less than 20% of the total) and lack ribs. The vertebrae have projections that allow for strong muscle attachment, enabling locomotion without limbs.

Caudal autotomy (self-amputation of the tail), a feature found in some lizards, is absent in most snakes. In the rare cases where it does exist in snakes, caudal autotomy is intervertebral (meaning the separation of adjacent vertebrae), unlike that in lizards, which is intravertebral, i.e. the break happens along a predefined fracture plane present on a vertebra.

In some snakes, most notably boas and pythons, there are vestiges of the hindlimbs in the form of a pair of pelvic spurs. These small, claw-like protrusions on each side of the cloaca are the external portion of the vestigial hindlimb skeleton, which includes the remains of an ilium and femur.

Snakes are polyphyodonts with teeth that are continuously replaced.