information:filtering, stylistic:tone, stylistic:style_transfer
Preparation

The first laboratory preparation of nicotine (as its racemate) was described in 1904.

The starting material was an N-substituted pyrrole derivative, which was heated to convert it by a sigmatropic shift to the isomer with a carbon bond between the pyrrole and pyridine rings, followed by methylation and selective reduction of the pyrrole ring using tin and hydrochloric acid. Many other syntheses of nicotine, in both racemic and chiral forms have since been published.