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Western Mediterranean

Southern Italy (Magna Graecia) and south-eastern Sicily had been colonized by the Greeks during the 8th century BC. In 4th-century BC Sicily the leading Greek city and hegemon was Syracuse. During the Hellenistic period the leading figure in Sicily was Agathocles of Syracuse (361–289 BC) who seized the city with an army of mercenaries in 317 BC. Agathocles extended his power throughout most of the Greek cities in Sicily, fought a long war with the Carthaginians, at one point invading Tunisia in 310 BC and defeating a Carthaginian army there. This was the first time a European force had invaded the region. After this war he controlled most of south-east Sicily and had himself proclaimed king, in imitation of the Hellenistic monarchs of the east. Agathocles then invaded Italy (c. 300 BC) in defense of Tarentum against the Bruttians and Romans, but was unsuccessful.

Greeks in pre-Roman Gaul were mostly limited to the Mediterranean coast of Provence, France. The first Greek colony in the region was Massalia, which became one of the largest trading ports of Mediterranean by the 4th century BC with 6,000 inhabitants. Massalia was also the local hegemon, controlling various coastal Greek cities like Nice and Agde. The coins minted in Massalia have been found in all parts of Liguro-Celtic Gaul. Celtic coinage was influenced by Greek designs, and Greek letters can be found on various Celtic coins, especially those of Southern France. Traders from Massalia ventured inland deep into France on the Rivers Durance and Rhône, and established overland trade routes deep into Gaul, and to Switzerland and Burgundy. The Hellenistic period saw the Greek alphabet spread into southern Gaul from Massalia (3rd and 2nd centuries BC) and according to Strabo, Massalia was also a center of education, where Celts went to learn Greek. A staunch ally of Rome, Massalia retained its independence until it sided with Pompey in 49 BC and was then taken by Caesar's forces.

The city of Emporion (modern Empúries), originally founded by Archaic-period settlers from Phocaea and Massalia in the 6th century BC near the village of Sant Martí d'Empúries (located on an offshore island that forms part of L'Escala, Catalonia, Spain), was reestablished in the 5th century BC with a new city (neapolis) on the Iberian mainland. Emporion contained a mixed population of Greek colonists and Iberian natives, and although Livy and Strabo assert that they lived in different quarters, these two groups were eventually integrated. The city became a dominant trading hub and center of Hellenistic civilization in Iberia, eventually siding with the Roman Republic against the Carthaginian Empire during the Second Punic War (218–201 BC). However, Emporion lost its political independence around 195 BC with the establishment of the Roman province of Hispania Citerior and by the 1st century BC had become fully Romanized in culture.