quality:correction, information:classification
Deep-sky objects

The band of the Milky Way goes through Canis Major, with only patchy obscurement by interstellar dust clouds. It is bright in the northeastern corner of the constellation, as well as in a triangular area between Adhara, Wezen and Aludra, with many stars visible in binoculars. Canis Major boasts several open clusters. The only Messier object is M41 (NGC 2287), an open cluster with a combined visual magnitude of 4.5, around 2300 light-years from Earth. Located 4 degrees south of Sirius, it contains contrasting blue, yellow and orange stars and covers an area the apparent size of the full moon —in reality around 25 light-years in diameter. Its most luminous stars have already evolved into giants. The brightest is a 6.3-magnitude star of spectral type K3. Located in the field is 12 Canis Majoris, though this star is only 670 light-years distant. NGC 2360, known as Caroline's Cluster after its discoverer Caroline Herschel, is an open cluster located 3.5 degrees west of Muliphein and has a combined apparent magnitude of 7.2. Around 15 light-years in diameter, it is located 3700 light-years away from Earth, and has been dated to around 2.2 billion years old. NGC 2362 is a small, compact open cluster, 5200 light-years from Earth. It contains about 60 stars, of which Tau Canis Majoris is the brightest member. Located around 3 degrees northeast of Wezen, it covers an area around 12 light-years in diameter, though the stars appear huddled around Tau when seen through binoculars. It is a very young open cluster as its member stars are only a few million years old. Lying 2 degrees southwest of NGC 2362 is NGC 2354 a fainter open cluster of magnitude 6.5, with around 15 member stars visible with binoculars. Located around 30' northeast of NGC 2360, NGC 2359 (Thor's Helmet or the Duck Nebula) is a relatively bright emission nebula in Canis Major, with an approximate magnitude of 10, which is 10,000 light-years from Earth. The nebula is shaped by HD 56925, an unstable Wolf–Rayet star embedded within it.

In 2003, an overdensity of stars in the region was announced to be the Canis Major Dwarf, the closest satellite galaxy to Earth. However, there remains debate over whether it represents a disrupted dwarf galaxy or in fact a variation in the thin and thick disk and spiral arm populations of the Milky Way. Investigation of the area yielded only ten RR Lyrae variables —consistent with the Milky Way's halo and thick disk populations rather than a separate dwarf spheroidal galaxy. On the other hand, a globular cluster in Puppis, NGC 2298 —which appears to be part of the Canis Major dwarf system—is extremely metal-poor, suggesting it did not arise from the Milky Way's thick disk, and instead is of extragalactic origin.

NGC 2207 and IC 2163 are a pair of face-on interacting spiral galaxies located 125 million light-years from Earth. About 40 million years ago, the two galaxies had a close encounter and are now moving farther apart; nevertheless, the smaller IC 2163 will eventually be incorporated into NGC 2207. As the interaction continues, gas and dust will be perturbed, sparking extensive star formation in both galaxies. Supernovae have been observed in NGC 2207 in 1975 (type Ia SN 1975a), 1999 (the type Ib SN 1999ec), 2003 (type 1b supernova SN 2003H), and 2013 (type II supernova SN 2013ai). Located 16 million light-years distant, ESO 489-056 is an irregular dwarf- and low-surface-brightness galaxy that has one of the lowest metallicities known.