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International Space Station

With regard to the International Space Station (ISS), ESA is not represented by all of its member states: 11 of the 22 ESA member states currently participate in the project: Belgium, Denmark, France, Germany, Italy, Netherlands, Norway, Spain, Sweden, Switzerland and United Kingdom. Austria, Finland and Ireland chose not to participate, because of lack of interest or concerns about the expense of the project. Portugal, Luxembourg, Greece, the Czech Republic, Romania, Poland, Estonia and Hungary joined ESA after the agreement had been signed.

ESA takes part in the construction and operation of the ISS, with contributions such as Columbus, a science laboratory module that was brought into orbit by NASA's STS-122 Space Shuttle mission, and the Cupola observatory module that was completed in July 2005 by Alenia Spazio for ESA. The current estimates for the ISS are approaching €100 billion in total (development, construction and 10 years of maintaining the station) of which ESA has committed to paying €8 billion. About 90% of the costs of ESA's ISS share will be contributed by Germany (41%), France (28%) and Italy (20%). German ESA astronaut Thomas Reiter was the first long-term ISS crew member.

ESA has developed the Automated Transfer Vehicle for ISS resupply. Each ATV has a cargo capacity of 7,667 kilograms (16,903 lb). The first ATV, Jules Verne, was launched on 9 March 2008 and on 3 April 2008 successfully docked with the ISS. This manoeuvre, considered a major technical feat, involved using automated systems to allow the ATV to track the ISS, moving at 27,000 km/h, and attach itself with an accuracy of 2 cm. Five vehicles were launched before the program ended with the launch of the fifth ATV, Georges Lemaître, in 2014.

As of 2020, the spacecraft establishing supply links to the ISS are the Russian Progress and Soyuz, Japanese Kounotori (HTV), and the United States vehicles Cargo Dragon 2 and Cygnus stemmed from the Commercial Resupply Services program.

European Life and Physical Sciences research on board the International Space Station (ISS) is mainly based on the European Programme for Life and Physical Sciences in Space programme that was initiated in 2001.