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Views on the U.S.

On November 11, 2003, in an interview with The Washington Post, Soros said that removing President George W. Bush from office was the "central focus of my life" and "a matter of life and death". He said he would sacrifice his entire fortune to defeat Bush "if someone guaranteed it". Soros gave $3 million to the Center for American Progress, $2.5 million to MoveOn.org, and $20 million to America Coming Together. These groups worked to support Democrats in the 2004 election. On September 28, 2004, he dedicated more money to the campaign and kicked off his own multistate tour with a speech, "Why We Must Not Re-elect President Bush", delivered at the National Press Club in Washington, D.C. The online transcript of this speech received many views after Dick Cheney accidentally referred to FactCheck.org as "factcheck.com" in the vice presidential debate, causing the owner of that domain to redirect all traffic to Soros's site.

His 2003 book, The Bubble of American Supremacy, was a forthright critique of the Bush administration's "War on Terror" as misconceived and counterproductive, and a polemic against the re-election of Bush. He explains the title in the closing chapter by pointing out the parallels in this political context with the self-reinforcing reflexive processes that generate bubbles in stock prices.

When Soros was asked in 2006 about his statement in The Age of Fallibility that "the main obstacle to a stable and just world order is the United States", he responded that "it happens to coincide with the prevailing opinion in the world. And I think that's rather shocking for Americans to hear. The United States sets the agenda for the world. And the rest of the world has to respond to that agenda. By declaring a 'war on terror' after September 11, we set the wrong agenda for the world... When you wage war, you inevitably create innocent victims."

In 2017, Soros described Donald Trump as a con man, and predicted Trump would fail because he believed Trump's ideas were self-contradictory. Soros also said he believed Trump was preparing for a trade war and expected financial markets to do poorly.