structural:reformatting, information:highlighting, structural:scholar_edition, linguistic:paraphrasing
Neurophysiology

The paternal copy of UBE3A is silenced within the hippocampus, cortex, thalamus, olfactory bulb, and cerebellum. Therefore, a functioning maternal copy of UBE3A is essential for proper development in these brain regions. Of the areas of the brain implicated in AS, the hippocampus, cortex, and cerebellum have been extensively studied. Findings from these three brain regions are outlined below.