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Christianity

Antioch was a chief center of early Christianity during Roman times. The city had a large population of Jewish origin in a quarter called the Kerateion, and so attracted the earliest missionaries. Evangelized by, among others, Peter himself, according to the tradition upon which the Patriarchate of Antioch still rests its claim for primacy, its converts were the first to be called Christians. This is not to be confused with Antioch in Pisidia, to which Barnabas and Paul of Tarsus later travelled.

Between 252 and 300 AD, ten assemblies of the church were held at Antioch and it became the seat of one of the five original patriarchates, along with Constantinople, Jerusalem, Alexandria, and Rome (see Pentarchy). Today five churches use the title of patriarch of Antioch for their prime bishops: one Oriental Orthodox (the Syriac Orthodox Church); three Eastern Catholic (the Maronite, Syriac Catholic, and Melkite Greek Catholic Churches); and one Eastern Orthodox (the Greek Orthodox Church of Antioch). This title has been maintained though most of them have moved their seat to Damascus. This is somewhat analogous to the manner in which several popes, heads of the Roman Catholic Church remained "Bishop of Rome" even while residing in Avignon, in present-day France, in the fourteenth century. The Maronite Church, which has also moved the seat away to Bkerké, Lebanon, continues the Antiochene liturgical tradition and the use of the Syro-Aramaic language in their liturgies.

Emperor Constantine who had decriminalised Christianity in 313, begun the building of the Domus Aurea or Great Church in 327 which served for the next two centuries as the leading church of Antioch.

John Chrysostom writes that when Ignatius of Antioch was bishop in the city, the dêmos, probably meaning the number of free adult men and women without counting children and slaves, numbered 200,000. In a letter written in 363, Libanius says the city contains 150,000 anthrôpoi (plural of anthropos, human) a word which would ordinarily mean all human beings of any age, sex, or social status, seemingly indicating a decline in the population since the first century. Chrysostom also says in one of his homilies on the Gospel of Matthew, which were delivered between 386 and 393, that in his own time there were 100,000 Christians in Antioch, a figure which may refer to orthodox Christians who belonged to the Great Church as opposed to members of other groups such as Arians and Apollinarians, or to all Christians of any persuasion.