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NMDA-type ionotropic glutamate receptors

Hebian plasticity is believed to involve N-methyl-d-aspartate receptors (NMDARs) and are located on postsynaptic neurons in the lateral amygdala. NMDARs are known to be coincidence detectors of presynaptic activity and postsynaptic depolarization. Auditory inputs are NMDARs in the lateral amygdala and use glutamate as a transmitter. Furthermore, it was tested that when the region's neurons that received auditory inputs also received unconditioned stimulus inputs and broad spectrum NMDAR antagonists in the lateral amygdala resulted in the disruption of the acquisition of fear learning. Therefore, these receptors are crucial to the metabolic pathway of processing and eliciting for the percept of fear.