linguistic:paraphrasing, linguistic:translation
Return to success (2000–present)

In 2000, Bachchan appeared in Aditya Chopra 's romantic blockbuster Mohabbatein. He played a stern, elder figure who rivalled the character of Shahrukh Khan. His role won him his third Filmfare Award for Best Supporting Actor. Other hits followed, with Bachchan appearing as an older family patriarch in Ek Rishtaa: The Bond of Love (2001), Kabhi Khushi Kabhie Gham... (2001) and Baghban (2003). As an actor, he continued to perform in a range of characters, receiving critical praise for his performances in Aks (2001), Aankhen (2002), Kaante (2002), Khakee (2004), Dev (2004) and Veer-Zaara (2004). His performance in Aks won him his first Filmfare Critics Award for Best Actor.

One project that did particularly well for Bachchan was Sanjay Leela Bhansali 's Black (2005). The film starred Bachchan as an ageing teacher of a deaf-blind girl and followed their relationship. His performance was unanimously praised by critics and audiences and won him his second National Film Award for Best Actor, his fourth Filmfare Best Actor Award, and his second Filmfare Critics Award for Best Actor. Taking advantage of this resurgence, Amitabh began endorsing a variety of products and services, appearing in many television and billboard advertisements. In 2005 and 2006, he starred with his son Abhishek in the films Bunty Aur Babli (2005), the Godfather adaptation Sarkar (2005), and Kabhi Alvida Naa Kehna (2006). All of them were successful at the box office. His later releases in 2006 and early 2007 were Baabul (2006), Ekalavya (2007) and Nishabd (2007), which failed to do well at the box office but his performances in each of them were praised by critics.

In May 2007, two of his films, the romantic comedy Cheeni Kum and the multi-starrer action drama Shootout at Lokhandwala, were released. Shootout at Lokhandwala did well at the box office and was declared a hit in India, while Cheeni Kum picked up after a slow start and was declared a semi-hit by the end of its theatrical run. A remake of his biggest hit, Sholay (1975), entitled Ram Gopal Varma Ki Aag, released in August of that same year and proved to be a major commercial failure in addition to its poor critical reception. The year also marked Bachchan's first appearance in an English-language film, Rituparno Ghosh 's The Last Lear, co-starring Arjun Rampal and Preity Zinta. The film premiered at the 2007 Toronto International Film Festival on 9 September 2007. He received positive reviews from critics who hailed his performance as his best since Black. Bachchan was slated to play a supporting role in his first international film, Shantaram, directed by Mira Nair and starring Hollywood actor Johnny Depp in the lead. The film was due to begin filming in February 2008 but due to the writer's strike, was pushed to September 2008. The film is currently "shelved" indefinitely.

Vivek Sharma 's Bhoothnath, in which he plays the title role as a ghost, was released on 9 May 2008. Sarkar Raj, the sequel of the 2005 film Sarkar, released in June 2008 and received a positive response at the box office. Paa, which was released at the end of 2009 was a highly anticipated project as it saw him playing his own son Abhishek's Progeria -affected 13-year-old son, and it opened to favourable reviews, particularly towards Bachchan's performance and was one of the top-grossing films of 2009. It won him his third National Film Award for Best Actor and fifth Filmfare Best Actor Award. In 2010, he debuted in Malayalam film through Kandahar, directed by Major Ravi and co-starring Mohanlal. The film was based on the hijacking incident of the Indian Airlines Flight 814. Bachchan declined any remuneration for this film. In 2011 he played an aged retired former gangster in Bbuddah... Hoga Terra Baap who protects his son Sonu Sood who is an honest daring police officer from a notorious gangster Prakash Raj who unknowingly hired the latter to perform a contract killing not knowing that the police officer is the gangster's son. Despite huge expectations, it flopped at the box office.

In 2013, he made his Hollywood debut in The Great Gatsby making a special appearance opposite Leonardo DiCaprio and Tobey Maguire. In 2014, he played the role of the friendly ghost in the sequel Bhoothnath Returns. The next year, he played the role of a grumpy father experiencing chronic constipation in the critically acclaimed Piku which was also one of the biggest hits of 2015. A review in Daily News and Analysis (DNA) summarised Bachchan's performance as "The heart and soul of Piku clearly belong to Amitabh Bachchan who is in his elements. His performance in Piku, without doubt, finds a place among the top 10 in his illustrious career." Rachel Saltz wrote for The New York Times, "Piku", an offbeat Hindi comedy, would have you contemplate the intestines and mortality of one Bhashkor Banerji and the actor who plays him, Amitabh Bachchan. Bhashkor's life and conversation may revolve around his constipation and fussy hypochondria, but there's no mistaking the scene-stealing energy that Mr. Bachchan, India's erstwhile Angry Young Man, musters for his new role of Cranky Old Man." Well known Indian critic Rajeev Masand wrote on his website, "Bachchan is pretty terrific as Bhashkor, who reminds you of that oddball uncle that you nevertheless have a soft spot for. He bickers with the maids, harrows his hapless helper, and expects Piku to stay unmarried so she can attend to him. At one point, to ward off a possible suitor, he casually mentions that his daughter isn't a virgin; that she's financially independent and sexually independent too. Bachchan embraces the character's many idiosyncrasies, never once slipping into caricature while all along delivering big laughs thanks to his spot-on comic timing." The Guardian summed up, "Bachchan seizes upon his cranky character part, making Bashkor as garrulously funny in his theories on caste and marriage as his system is backed-up." The performance won Bachchan his fourth National Film Award for Best Actor and his third Filmfare Critics Award for Best Actor.

In 2016, he appeared in the women-centric courtroom drama film Pink which was highly praised by critics and with an increasingly good word of mouth, was a resounding success at the domestic and overseas box office. Bachchan's performance in the film received acclaim. According to Raja Sen of Rediff.com, "Amitabh Bachchan, a retired lawyer with bipolar disorder, takes up cudgels on behalf of the girls, delivering courtroom blows with pugilistic grace. As we know from Prakash Mehra movies, in each life some Bachchan must fall. The girls hang on to him with incredulous desperation, and he bats for them with all he has. At one point Meenal hangs by Bachchan's elbow, words entirely unnecessary. Bachchan towers through Pink – the way he bellows "et cetera" is alone worth having the heavy-hitter at play—but there are softer moments like one where he appears to have dozed off in court, or where he lays his head by his convalescent wife's bedside and needs his hair ruffled and his conviction validated." Writing for Hindustan Times, noted film critic and author Anupama Chopra said of Bachchan's performance, "A special salute to Amitabh Bachchan, who imbues his character with a tragic majesty. Bachchan towers in every sense, but without a hint of showboating. Meena Iyer of The Times of India wrote, "The performances are pitch-perfect with Bachchan leading the way. Writing for NDTV, Troy Ribeiro of Indo-Asian News Service (IANS) stated, "Amitabh Bachchan as Deepak Sehgall, the aged defence lawyer, shines as always, in a restrained, but powerful performance. His histrionics come primarily in the form of his well-modulated baritone, conveying his emotions and of course, from the well-written lines." Mike McCahill of The Guardian remarked, "Among an electric ensemble, Taapsee Pannu, Kirti Kulhari and Andrea Tariang give unwavering voice to the girls' struggles; Amitabh Bachchan brings his moral authority to bear as their sole legal ally.

In 2017, he appeared in the third instalment of the Sarkar film series: Ram Gopal Varma 's Sarkar 3. That year, he started filming for the swashbuckling action-adventure film Thugs of Hindostan with Aamir Khan, Katrina Kaif and Fatima Sana Shaikh which released in November 2018. He co-starred with Rishi Kapoor in 102 Not Out, a comedy drama film directed by Umesh Shukla based on a Gujarati play of the same name written by Saumya Joshi. This film released in May 2018 and reunited him with Kapoor onscreen after a gap of 27 years.

In 2019, Bachchan appeared in Sujoy Ghosh 's mystery thriller Badla. The film did a lifetime business of ₹ 1.38 billion (equivalent to ₹ 1.7 billion or US$21 million in 2023) worldwide to emerge a box office hit. The following year, he co-starred alongside Ayushmann Khurana in Shoojit Sircar 's comedy drama Gulabo Sitabo, which opened to critical acclaim & won him Filmfare Award for Best Actor (Critics). He then collaborated with Emraan Hashmi for Chehre (2021), which was a critical and commercial failure.

The next year, Bachchan had five releases, out of which Ayan Mukerji 's highly anticipated fantasy action-adventure film Brahmāstra: Part One – Shiva proved to be a hit as well as the highest-grossing Hindi film of 2022 while Jhund, Runway 34 and Uunchai didn't do well at ticket counters, but met with positive response from critics. In 2024, he played Ashwatthama in Nag Ashwin 's Kalki 2898 AD, marking his Telugu debut.