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Post-colonial

Subsequently, Guinea aligned itself with the Soviet Union and adopted socialist policies. It then moved towards a Chinese model of socialism. It continued to receive investment from capitalist countries, such as the United States. By 1960, Touré had declared PDG the country's only legal political party, and for the next 24 years, the government and PDG were one. Touré was re-elected unopposed to 4 7-year terms as president, and every 5 years voters were presented with a single list of PDG candidates for the National Assembly. Advocating a hybrid African Socialism domestically and Pan-Africanism abroad, Touré became a polarising leader, with his government becoming intolerant of dissent, imprisoning thousands, and stifling the press.

Throughout the 1960s, the Guinean government nationalised land, removed French-appointed and traditional chiefs from power, and had strained ties with the French government and French companies. Touré's government relied on the Soviet Union and China for infrastructure aid and development, and much of this was used for political and not economic purposes, such as the building of stadiums to hold political rallies.

On 22 November 1970, Portuguese forces from neighbouring Portuguese Guinea staged Operation Green Sea, a raid on Conakry by several hundred exiled Guinean opposition forces. Among their goals, the Portuguese military wanted to kill or capture Sekou Touré due to his support of PAIGC, an independence movement and rebel group that had carried out attacks inside Portuguese Guinea from their bases in Guinea. After some fighting, the Portuguese-backed forces retreated, having freed several dozen Portuguese prisoners of war that were being held by PAIGC in Conakry, and without having ousted Touré. In the years after the raid, purges were carried out by the Touré government, and at least 50 thousand people were killed. Others were imprisoned and faced torture. Some foreigners were forced to leave the country, after having had their Guinean spouse arrested and their children placed into state custody.

Guinea was elected as a non-permanent member of the UN Security Council 1972–73.

In 1977, a declining economy, mass killings, a stifling political atmosphere, and a ban on all private economic transactions led to the Market Women's Revolt, a series of anti-government riots started by women working in Conakry's Madina Market. This prompted Touré to make major reforms. Touré vacillated from supporting the Soviet Union to supporting the United States. The late 1970s and early 1980s saw some economic reforms, while Touré's centralized control of the state remained. Regarding its relationship with France, after the election of Valéry Giscard d'Estaing as French president, trade increased and the two countries exchanged diplomatic visits.

Sékou Touré died on 26 March 1984, after a heart operation in the United States, and was replaced by Prime Minister Louis Lansana Beavogui, who was to serve as interim president, pending new elections. PDG was due to elect a new leader on 3 April 1984. Under the constitution, that person would have been the only candidate for president. Hours before that meeting, Colonels Lansana Conté and Diarra Traoré seized power in a bloodless coup. Conté assumed the role of president, with Traoré serving as prime minister, until December.

Conté denounced the previous regime's record on human rights, releasing 250 political prisoners and encouraging approximately 200 thousand more to return from exile. He made explicit the turn away from socialism.

In 1992, Conté announced a return to civilian rule, with a presidential poll in 1993, followed by elections to parliament in 1995 (in which his party—the Party of Unity and Progress —won 71 of 114 seats.) In September 2001, the opposition leader Alpha Condé was imprisoned for endangering state security and pardoned 8 months later. Subsequently, he spent time in exile in France.

In 2001, Conté organized and won a referendum to lengthen the presidential term, and in 2003, began his third term after elections were boycotted by the opposition. In January 2005, Conté survived a suspected assassination attempt while making a public appearance in the capital of Conakry. His opponents claimed that he was a "tired dictator", whose departure was inevitable, whereas his supporters believed that he was winning a battle with dissidents. According to Foreign Policy, Guinea was in danger of becoming a failed state.

In 2000, Guinea suffered from the instability which had blighted the rest of West Africa, as rebels crossed the borders from Liberia and Sierra Leone. It seemed that the country was headed for civil war. Conté blamed neighbouring leaders for coveting Guinea's natural resources, and these claims were denied. In 2003, Guinea agreed to plans with her neighbours to tackle the insurgents. The 2007 Guinean general strike resulted in the appointment of a new prime minister.

Conté remained in power until his death on 23 December 2008. Several hours after his death, Moussa Dadis Camara seized control in a coup, declaring himself head of a military junta. Protests against the coup became violent, and 157 people were killed when, on 28 September 2009, the junta ordered its soldiers to attack people gathered to protest Camara's attempt to become president. The soldiers went on a rampage of rape, mutilation, and murder, which caused some foreign governments to withdraw their support for the new regime.

On 3 December 2009, an aide shot Camara during a dispute over the rampage in September. Camara went to Morocco for medical care. Vice-president (and defense minister) Sékouba Konaté flew from Lebanon to run the country. After meeting in Ouagadougou on 13 and 14 January 2010, Camara, Konaté and Blaise Compaoré, President of Burkina Faso, produced a formal statement of 12 principles promising a return of Guinea to civilian rule within 6 months. The presidential election of 27 June brought allegations of fraud, and a second election was held on 7 November. Voter turnout was "high", and the elections went "relatively smoothly". Alpha Condé, leader of the opposition party Rally of the Guinean People (RGP), won the election, promising to reform the security sector and review mining contracts.

In February 2013, political violence erupted after street protests over transparency of upcoming May elections. The protests were fueled by the opposition coalition's decision to step down from the elections, in protest of the lack of transparency in the preparations for elections. 9 people were killed during the protests, and around 220 were injured. Some deaths and injuries were caused by security forces using live ammunition on protesters. The violence led to ethnic clashes between the Malinke and Fula, who supported and opposed President Condé, respectively. On 26 March 2013, the opposition party backed out of negotiations with the government over the election, saying that the government had not respected them, and had broken all agreements.

On 25 March 2014, the World Health Organization stated that Guinea's Ministry of Health had reported an outbreak of Ebola virus disease in Guinea. This initial outbreak had 86 cases, including 59 deaths. By 28 May, there were 281 cases, with 186 deaths. It is believed that the first case was Emile Ouamouno, a 2-year-old boy in the village of Meliandou. He fell ill on 2 December 2013 and died on 6 December. On 18 September 2014, 8 members of an Ebola education health care team were murdered by villagers in the town of Womey. As of 1 November 2015, there had been 3,810 cases and 2,536 deaths in Guinea.

Mass civil unrest and violent protests broke out against the rule of Alpha Conde on October 14, 2019, against constitutional changes. More than 800 were killed in clashes. After the 2020 Guinean presidential election, Alpha Condé's election to a third term was challenged by the opposition, who accused him of fraud. Condé claimed a constitutional referendum from March 2020 allowed him to run despite the 2-term limit.

On 5 September 2021, after hours of gunfire near the presidential palace, Lieutenant Colonel Mamady Doumbouya seized control of state television and declared that President Alpha Conde 's government had been dissolved and the nation's borders closed. By the evening, the putschists declared control of all Conakry and the country's armed forces. According to Guinée Matin, by 6 September the military fully controlled the state administration and started to replace the civil administration with its military counterpart. The United Nations, European Union, African Union, ECOWAS (which suspended Guinea's membership) and La Francophonie denounced the coup, and called for President Condé's unconditional release. Similar responses came from some neighboring and Western countries (including the United States), and from China (which relies on Guinea for half of its aluminum ore, facilitated by its connections to President Condé). Despite these, On 1 October 2021, Mamady Doumbouya was sworn in as interim President.

On 11 May 2023, at least 7 people were shot dead in anti-government demonstrations in cities across Guinea. The anti-government movement became involved in peaceful protests and called on rulers to end military rule in Guinea and transition the country to democracy.

On 18 December 2023, an explosion occurred at the country's main oil depot in Conakry, killing 24 people and causing extensive fuel shortages in the country in the following weeks. Existing civil and economic unrest in the country temporarily worsened as a result, with several confrontations between protestors and police in Conakry, increased fuel and travel costs, and general price inflation throughout the country.