information:extraction, quality:corruption
Long-term

The main active ingredient of wine is ethanol. A 2016 systematic review and meta-analysis found that moderate ethanol consumption brought no mortality benefit compared with lifetime abstention from ethanol consumption. A systematic analysis of data from the Global Burden of Disease study found that consumption of ethanol increases the risk of cancer and increases the risk of all-cause mortality, and that the most healthful dose of ethanol is zero consumption. Some studies have concluded that drinking small quantities of alcohol (less than one drink daily in women and two drinks daily in men) is associated with a decreased risk of heart disease, stroke, diabetes mellitus, and early death. Ethanol consumption increases the risk of heart disease, high blood pressure, atrial fibrillation, and stroke. Some studies that reported benefits of moderate ethanol consumption erred by lumping former drinkers and life-long abstainers into a single group of nondrinkers, hiding the health benefits of life-long abstention from ethanol. Risk is greater in younger people due to binge drinking which may result in violence or accidents. About 3.3 million deaths (5.9% of all deaths) annually are due to ethanol use.

Alcohol use disorder is the inability to stop or control alcohol use despite harmful consequences to health, job, or relationships; alternative terms include alcoholism, alcohol abuse, alcohol dependence, or alcohol addiction. and alcohol use is the third leading cause of early death in the United States. No professional medical association recommends that people who are nondrinkers should start drinking wine.

Excessive consumption of alcohol can cause liver cirrhosis and alcoholism. The American Heart Association "cautions people NOT to start drinking... if they do not already drink alcohol. Consult your doctor on the benefits and risks of consuming alcohol in moderation."

Although red wine contains more of the stilbene resveratrol and of other polyphenols than white wine, the evidence for a cardiac health benefit is of poor quality and at most, the benefit is trivial. Grape skins naturally produce resveratrol in response to fungal infection, including exposure to yeast during fermentation. White wine generally contains lower levels of the chemical as it has minimal contact with grape skins during this process.