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In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula R−C(=O)−NR′R″, where R, R', and R″ represent any group, typically organyl groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, as in asparagine and glutamine. It can be viewed as a derivative of a carboxylic acid (R−C(=O)−OH) with the hydroxyl group (−OH) replaced by an amine group (−NR′R″); or, equivalently, an acyl (alkanoyl) group (R−C(=O)−) joined to an amine group.

Common of amides are formamide (H−C(=O)−NH), acetamide (H C−C(=O)−NH), benzamide (C H −C(=O)−NH), and dimethylformamide (H−C(=O)−N(−CH)). Some uncommon examples of amides are N -chloroacetamide (H C−C(=O)−NH−Cl) and chloroformamide (Cl−C(=O)−NH).

Amides are qualified as primary, secondary, and tertiary according to whether the amine subgroup has the form −NH, −NHR, or −NRR', where R and R' are groups other than hydrogen.