structural:scholar_edition, quality:corruption
Spanish explorers

In September 1540, under orders from the conquistador Francisco Vázquez de Coronado to search for the fabled Seven Cities of Cibola, Captain García López de Cárdenas, along with Hopi guides and a small group of Spanish soldiers, traveled to the south rim of the Grand Canyon between Desert View and Moran Point. Pablo de Melgrossa, Juan Galeras, and a third soldier descended some one third of the way into the canyon until they were forced to return because of lack of water. In their report, they noted that some of the rocks in the canyon were "bigger than the great tower of Seville, Giralda ". It is speculated that their Hopi guides likely knew routes to the canyon floor, but may have been reluctant to lead the Spanish to the river. No Europeans visited the canyon again for more than two hundred years.

Fathers Francisco Atanasio Domínguez and Silvestre Vélez de Escalante were two Spanish priests who, with a group of Spanish soldiers, explored southern Utah and traveled along the north rim of the canyon in Glen and Marble Canyons in search of a route from Santa Fe to California in 1776. They eventually found a crossing, formerly known as the "Crossing of the Fathers", that today lies under Lake Powell.

Also in 1776, Fray Francisco Garces, a Franciscan missionary, spent a week near Havasupai unsuccessfully attempting to convert a band of Native Americans to Christianity. He described the canyon as "profound".