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Revolt of the Arab client states (602)

The Byzantine clients, the Arab Ghassanids, converted to the Monophysite form of Christianity, which was regarded as heretical by the established Byzantine Eastern Orthodox Church. The Byzantines attempted to suppress the heresy, alienating the Ghassanids and sparking rebellions on their desert frontiers. The Lakhmids also revolted against the Persian king Khusrau II. Nu'man III (son of Al-Monder IV), the first Christian Lakhmid king, was deposed and killed by Khusrau II in 602, because of his attempt to throw off Persian suzerainty. After Khusrau's assassination in 628, the Persian Empire fractured and the Lakhmids were effectively semi-independent. It is now widely believed that the annexation of the Lakhmid kingdom was one of the main factors behind the fall of the Sasanian Empire and the subsequent Islamic conquest of Persia, as the Lakhmids agreed to act as spies for the Muslims after being defeated in the Battle of Hira by Khalid ibn al-Walid.