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Personal relationships

Alexander married three times: Roxana, daughter of the Sogdian nobleman Oxyartes of Bactria, out of love; and the Persian princesses Stateira and Parysatis, the former a daughter of Darius III and the latter a daughter of Artaxerxes III, for political reasons. He apparently had two sons, Alexander IV of Macedon by Roxana and, possibly, Heracles of Macedon from his mistress Barsine. He lost another child when Roxana miscarried at Babylon.

Alexander also had a close relationship with his friend, general, and bodyguard Hephaestion, the son of a Macedonian noble. Hephaestion's death devastated Alexander. This event may have contributed to Alexander's failing health and detached mental state during his final months.