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2012–2016: Super Bowl XLVI halftime show, MDNA, and Rebel Heart

In February 2012, Madonna headlined the Super Bowl XLVI halftime show at the Lucas Oil Stadium in Indianapolis, Indiana. Her performance was visualized by Cirque Du Soleil and Jamie King, and featured special guests LMFAO, Nicki Minaj, M.I.A. and CeeLo Green. It became the then most-watched Super Bowl halftime show in history with 114 million viewers, higher than the game itself. During the event, she performed " Give Me All Your Luvin' ", the lead single from her twelfth studio album, MDNA. It became her record-extending 38th top-ten single on the Billboard Hot 100.

MDNA was released in March 2012 and saw collaboration with various producers, including William Orbit and Martin Solveig. It was her first release under her three-album deal with Interscope Records, which she signed as a part of her 360 deal with Live Nation. She was signed to the record label since Live Nation was unable to distribute music recordings. MDNA became Madonna's fifth consecutive studio record to debut at the top of the Billboard 200. The album was mostly promoted by the MDNA Tour, which lasted from May to December 2012. The tour featured controversial subjects such as violence, firearms, human rights, nudity and politics. With a gross of $305.2 million from 88 sold-out shows, it became the highest-grossing tour of 2012 and then-tenth highest-grossing tour of all time. Madonna was named the top-earning celebrity of the year by Forbes, earning an estimated $125 million.

Madonna collaborated with Steven Klein and directed a 17-minute film, secretprojectrevolution, which was released on BitTorrent in September 2013. With the film she launched the Art for Freedom initiative, which helped to promote "art and free speech as a means to address persecution and injustice across the globe". The website for the project included over 3,000 art related submissions since its inception, with Madonna regularly monitoring and enlisting other artists like David Blaine and Katy Perry as guest curators.

By 2013, Madonna's Raising Malawi had built ten schools to educate 4,000 children in Malawi at a value of $400,000. When Madonna visited the schools in April 2013, President of Malawi Joyce Banda accused her of exaggerating the charity's contribution. Madonna was saddened by Banda's statement, but clarified that she had "no intention of being distracted by these ridiculous allegations". It was later confirmed that Banda had not approved the statement released by her press team. Madonna also visited her hometown Detroit during May 2014, and donated funds to help with the city's bankruptcy. The same year, her business ventures extended to skin care products with the launch of MDNA Skin in Tokyo, Japan.

Madonna's thirteenth studio album, Rebel Heart, was released in March 2015, three months after its thirteen demos leaked onto the internet. Unlike her previous efforts, which involved only a few people, Madonna worked with a large number of collaborators, including Avicii, Diplo and Kanye West. Introspection was listed as one of the foundational themes prevalent on the record, along with "genuine statements of personal and careerist reflection". Madonna explained to Jon Pareles of The New York Times that, although she has never looked back at her past endeavors, reminiscing about it felt right for Rebel Heart. Music critics responded positively towards the album, calling it her best effort in a decade.

From September 2015 to March 2016, Madonna embarked on the Rebel Heart Tour to promote the album. The tour traveled throughout North America, Europe and Asia and was Madonna's first visit to Australia in 23 years, where she also performed a one-off show for her fans. The Rebel Heart Tour grossed a total of $169.8 million from the 82 shows, with over 1.045 million ticket sales. While on tour, Madonna became engaged in a legal battle with Ritchie, over the custody of their son Rocco. The dispute started when Rocco decided to continue living in England with Ritchie when the tour had visited there, while Madonna wanted him to travel with her. Court hearings took place in both New York and London. After multiple deliberations, Madonna withdrew her application for custody and decided to resolve the matter privately.

In October 2016, Billboard named Madonna its Woman of the Year. Her "blunt and brutally honest" speech about ageism and sexism at the ceremony received widespread coverage in the media. The next month Madonna, who actively supported Hillary Clinton during the 2016 US presidential election, performed an impromptu acoustic concert at Washington Square Park in support of Clinton's campaign. Upset that Donald Trump won the election, Madonna spoke out against him at the Women's March on Washington, a day after his inauguration. She sparked controversy when she said that she "thought a lot about blowing up the White House". The following day, Madonna asserted she was "not a violent person" and that her words had been "taken wildly out of context".