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17th–19th centuries

The recognition of the independence of the United Provinces by the Treaty of Münster in 1648 stipulated that the Scheldt should be closed to navigation, which destroyed Antwerp's trading activities. This impediment remained in force until 1863, although the provisions were relaxed during French rule from 1795 to 1814, and also during the time Belgium formed part of the Kingdom of the United Netherlands (1815 to 1830). Antwerp had reached the lowest point in its fortunes in 1800, and its population had sunk to under 40,000, when Napoleon, realizing its strategic importance, assigned funds to enlarge the harbour by constructing a new dock (still named the Bonaparte Dock), an access-lock and mole, and deepening the Scheldt to allow larger ships to approach Antwerp. Napoleon hoped that by making Antwerp's harbour the finest in Europe he would be able to counter the Port of London and hamper British growth. However, he was defeated at the Battle of Waterloo before he could see the plan through. In 1830, the city was captured by the Belgian insurgents, but the citadel continued to be held by a Dutch garrison under General David Hendrik Chassé. For a time, Chassé subjected the town to periodic bombardment which inflicted much damage, and at the end of 1832, the citadel itself was besieged by the French Northern Army commanded by Marechal Gerard. During this attack, the town was further damaged. In December 1832, after a gallant defence, Chassé made an honourable surrender, ending the Siege of Antwerp (1832).

Later that century, a double ring of Brialmont Fortresses was constructed some 10 km (6 mi) from the city centre, as Antwerp was considered vital for the survival of the young Belgian state. And in 1894 Antwerp presented itself to the world via a World's Fair attended by 3 million.