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Potential crewed exploration and habitation

In 2003 NASA conducted a conceptual study called Human Outer Planets Exploration (HOPE) regarding the future human exploration of the outer Solar System. The target chosen to consider in detail was Callisto.

The study proposed a possible surface base on Callisto that would produce rocket propellant for further exploration of the Solar System. Advantages of a base on Callisto include low radiation (due to its distance from Jupiter) and geological stability. Such a base could facilitate remote exploration of Europa, or be an ideal location for a Jovian system waystation servicing spacecraft heading farther into the outer Solar System, using a gravity assist from a close flyby of Jupiter after departing Callisto.

In December 2003, NASA reported that a crewed mission to Callisto might be possible in the 2040s.