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Neuroanatomy

A large amount of research has been conducted on the neuroscience of sadness. According to the American Journal of Psychiatry, sadness has been found to be associated with "increases in bilateral activity within the vicinity of the middle and posterior temporal cortex, lateral cerebellum, cerebellar vermis, midbrain, putamen, and caudate." Jose V. Pardo has his M.D and Ph.D and leads a research program in cognitive neuroscience. Using positron emission tomography (PET) Pardo and his colleagues were able to provoke sadness among seven normal men and women by asking them to think about sad things. They observed increased brain activity in the bilateral inferior and orbitofrontal cortex. In a study that induced sadness in subjects by showing emotional film clips, the feeling was correlated with significant increases in regional brain activity, especially in the prefrontal cortex, in the region called Brodmann's area 9, and the thalamus. A significant increase in activity was also observed in the bilateral anterior temporal structures.