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Classical antiquity (Beroea)

Alexander the Great took over the city in 333 BC. Seleucus Nicator established a Hellenic settlement in the site between 301 and 286 BC. He called it Beroea (Βέροια), after Beroea in Macedon; it is sometimes spelled as Beroia. Beroea is mentioned in 1 Macc. 9:4.

Northern Syria was the center of gravity of the Hellenistic colonizing activity, and therefore of Hellenistic culture in the Seleucid Empire. As did other Hellenized cities of the Seleucid kingdom, Beroea probably enjoyed a measure of local autonomy, with a local civic assembly or boulē composed of free Hellenes.

Beroea remained under Seleucid rule until 88 BC when Syria was conquered by the Armenian king Tigranes the Great and Beroea became part of the Kingdom of Armenia. After the Roman victory over Tigranes, Syria was handed over to Pompey in 64 BC, at which time they became a Roman province. Rome's presence afforded relative stability in northern Syria for over three centuries. Although the province was administered by a legate from Rome, Rome did not impose its administrative organization on the Greek-speaking ruling class or Aramaic speaking populace.

The Roman era saw an increase in the population of northern Syria that accelerated under the Byzantines well into the 5th century. In Late Antiquity, Beroea was the second largest Syrian city after Antioch, the capital of Roman Syria and the third largest city in the Roman world. Archaeological evidence indicates a high population density for settlements between Antioch and Beroea right up to the 6th century. This agrarian landscape still holds the remains of large estate houses and churches such as the Church of Saint Simeon Stylites.