quality:corruption, information:classification
End of the Hansa

The development of transatlantic trade after the discovery of the Americas caused the remaining kontors' decline, especially in Bruges, because it centred on other ports. It also changed business practice to short-term contracts and obsoleted the Hanseatic model of privileged guaranteed trade.

The trends of local feudal lords asserting control over towns and suppressing their autonomy, and of foreign rulers repressing Hanseatic traders continued in the next century.

In the Swedish War of Liberation 1521–1523, the Hanseatic League was successful in opposition in an economic conflict it had over the trade, mining and metal industry in Bergslagen (the main mining area of Sweden in the 16th century) with Jakob Fugger (industrialist in the mining and metal industry) and his unfriendly business take-over attempt. Fugger allied with his financially dependent pope Leo X, Maximilian I, Holy Roman Emperor and Christian II of Denmark/Norway. Both sides made costly investments in support of mercenaries to win the war. After the war, Gustav Vasa 's Sweden and Frederick I 's Denmark pursued independent policies and didn't support Lübeck's effort against Dutch trade.

However, Lübeck under Jürgen Wullenwever overextended in the Count's Feud in Scania and Denmark and lost influence in 1536 after Christian III 's victory. Lübeck's attempts at forcing competitors out of the Sound eventually alienated even Gustav Vasa. Its influence in the Nordic countries began to decline.

The Hanseatic towns of Guelders were obstructed in the 1530s by Charles II, Duke of Guelders. Charles, a strict Catholic, objected to Lutheranism, in his words "Lutheran heresy", of Lübeck and other north German cities. This frustrated but did not end the towns' Hanseatic trade and a small resurgence came later.

Later in the 16th century, Denmark-Norway took control of much of the Baltic. Sweden had regained control over its own trade, the Kontor in Novgorod had closed, and the Kontor in Bruges had become effectively moribund because the Zwin inlet was closing up. Finally, the growing political authority of the German princes constrained the independence of Hanse towns.

The league attempted to deal with some of these issues: it created the post of syndic in 1556 and elected Heinrich Sudermann to the position, who worked to protect and extend the diplomatic agreements of the member towns. In 1557 and 1579, revised agreements spelled out the duties of towns and some progress was made. The Bruges Kontor moved to Antwerp in 1520 and the Hansa attempted to pioneer new routes. However the league proved unable to prevent the growing mercantile competition.

In 1567, a Hanseatic League agreement reconfirmed previous obligations and rights of league members, such as common protection and defense against enemies. The Prussian Quartier cities of Thorn, Elbing, Königsberg and Riga and Dorpat also signed. When pressed by the King of Poland–Lithuania, Danzig remained neutral and would not allow ships running for Poland into its territory. They had to anchor somewhere else, such as at Pautzke (Puck).

The Antwerp Kontor, moribund after the fall of the city, closed in 1593. In 1597 Queen Elizabeth I of England expelled the League from London, and the Steelyard closed and sequestered in 1598. The Kontor returned in 1606 under her successor, James I, but it could not recover. The Bergen Kontor continued until 1754; of all the Kontore, only its buildings, the Bryggen, survive.

Not all states tried to suppress their cities' former Hanseatic links; the Dutch Republic encouraged its eastern former members to maintain ties with the remaining Hanseatic League. The States-General relied on those cities in diplomacy at the time of the Kalmar War.

The Thirty Years' War was destructive for the Hanseatic League and members suffered heavily from both the imperials, the Danes and the Swedes. At the beginning, Saxon and Wendish faced attacks because of the desire of Christian IV of Denmark to control the Elbe and Weser. Pomerania had a major population decline. Sweden took Bremen-Verden (excluding the city of Bremen), Swedish Pomerania (including Stralsund, Greifswald, Rostock) and Swedish Wismar, preventing their cities from participating in the League, and controlled the Oder, Weser and Elbe, and could levy tolls on their traffic. The league became increasingly irrelevant despite its inclusion in the Peace of Westphalia.

In 1666, the Steelyard burned in the Great Fire of London. The Kontor-manager sent a letter to Lübeck appealing for immediate financial assistance for a reconstruction. Hamburg, Bremen, and Lübeck called for a Hanseatic Day in 1669. Only a few cities participated and those who came were reluctant to contribute financially to the reconstruction. It was the last formal meeting, unbeknownst to any of the parties. This date is often taken in retrospect as the effective end date of the Hansa, but the League never formally disbanded. It silently disintegrated.