information:classification, linguistic:voice_change
Limitations

Additionally, GWA studies identify candidate risk variants for the population from which their analysis is performed, and with most GWA studies historically stemming from European databases, there is a lack of translation of the identified risk variants to other non-European populations. For instance, GWA studies for diseases like Alzheimer's disease have been conducted primarily in Caucasian populations, which does not give adequate insight in other ethnic populations, including African Americans or East Asians. Alternative strategies suggested involve linkage analysis. More recently, the rapidly decreasing price of complete genome sequencing have also provided a realistic alternative to genotyping array -based GWA studies. High-throughput sequencing does have potential to side-step some of the shortcomings of non-sequencing GWA. Cross-trait assortative mating can inflate estimates of genetic phenotype similarity.