linguistic:translation
Purine ribonucleotide synthesis

In the first reaction unique to purine nucleotide biosynthesis, PPAT catalyzes the displacement of PRPP's pyrophosphate group (PP) by an amide nitrogen donated from either glutamine (N), glycine (N&C), aspartate (N), folic acid (C), or CO. This is the committed step in purine synthesis. The reaction occurs with the inversion of configuration about ribose C, thereby forming β - 5-phosphorybosylamine (5-PRA) and establishing the anomeric form of the future nucleotide.