linguistic:paraphrasing
During the Spanish colonial period

Before the creation of the town, the inhabitants were scattered throughout the valley, with only a few families concentrated at the confluence of the Aná (today called the Santa Elena) and the Medellín rivers; others lived in El Poblado San Lorenzo. After the royal edict, the settlers chose the Aná site as the heart of the future city, with the Candelaria Church at its center.

Their first buildings were simple, with thatched roofs. The houses of the most important people were two stories tall, and the church and the Cabildo were unimpressive. It was only during the 18th century that the church was improved. Only one story, the Cabildo was located at the western part of the plaza. It had a thatched roof until 1742 when tiles were put on. In 1682, traders and foreigners started the construction of the Veracruz Hermitage, which was consecrated as a church by the Bishop of Popayán in 1712.

In 1675, the first census during colonial times was taken: there were 3,000 people and 280 families. Another census was not taken until the colonial Visitador (royal inspector) Antonio Mon y Velarde es ordered one between 1786 and 1787: there were then 14,507 people and 241 families. In 1808, two years before Colombia won independence, the city had 15,347 people and 360 families.

In 1803, the Royal College of the Franciscans was founded in the Central Plaza, which is Berrío Park today, with the initial departments of Grammar, Philosophy, and Theology. Soon after, the college moved to a new building in the small San Ignacio square. In 1821 it was renamed Colegio de Antioquia, and it became the University of Antioquia in 1901. The university also had the first vocational training school, the first cultural radio station in Latin America, and the first regional botanical garden.