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The Sierra Nevada's irregular northern boundary stretches from the Susan River and Fredonyer Pass to the North Fork Feather River. It represents where the granitic bedrock of the Sierra Nevada dives below the southern extent of Cenozoic igneous surface rock from the Cascade Range. It is bounded on the west by California 's Central Valley, on the east by the Basin and Range Province, and on the southeast by the Mojave Desert. The southern boundary is at Tehachapi Pass.

Physiographically, the Sierra is a section of the Cascade–Sierra Mountains province, which in turn is part of the larger Pacific Mountain System physiographic division. The California Geological Survey states that "the northern Sierra boundary is marked where bedrock disappears under the Cenozoic volcanic cover of the Cascade Range."