structural:reformatting, structural:expansion, information:filtering
Legacy

The Mona Lisa began influencing contemporary Florentine painting even before its completion. Raphael, who had been to Leonardo's workshop several times, promptly used elements of the portrait's composition and format in several of his works, such as Young Woman with Unicorn (c. 1506), and Portrait of Maddalena Doni (c. 1506). Later paintings by Raphael, such as La velata (1515–16) and Portrait of Baldassare Castiglione (c. 1514–15), continued to borrow from Leonardo's painting. Zollner states that "None of Leonardo's works would exert more influence upon the evolution of the genre than the Mona Lisa. It became the definitive example of the Renaissance portrait and perhaps for this reason is seen not just as the likeness of a real person, but also as the embodiment of an ideal."

Where earlier critics such as Vasari in the 16th century and André Félibien in the 17th praised the picture for its realism, by the mid-19th century, writers began to regard the Mona Lisa as imbued with a sense of mystery and romance. In 1859, Théophile Gautier wrote that the Mona Lisa was a "sphinx of beauty who smiles so mysteriously" and that "Beneath the form expressed one feels a thought that is vague, infinite, inexpressible. One is moved, troubled... repressed desires, hopes that drive one to despair, stir painfully." Walter Pater 's essay of 1869 described the sitter as "older than the rocks among which she sits; like the vampire, she has been dead many times, and learned the secrets of the grave; and has been a diver in the deep seas, and keeps their fallen day about her."

By the early 20th century, some critics started to feel the painting had become a repository for subjective exegeses and theories. Upon the painting's theft in 1911, Renaissance historian Bernard Berenson admitted that it had "simply become an incubus, and was glad to be rid of her." Jean Metzinger 's Le goûter (Tea Time) was exhibited at the 1911 Salon d'Automne and was sarcastically described as "la Joconde à la cuiller" (Mona Lisa with a spoon) by art critic Louis Vauxcelles on the front page of Gil Blas. André Salmon subsequently described the painting as "The Mona Lisa of Cubism".

The avant-garde art world has made note of the Mona Lisa ' s undeniable popularity. Because of the painting's overwhelming stature, Dadaists and Surrealists often produce modifications and caricatures. In 1883, Le rire, an image of a Mona Lisa smoking a pipe, by Sapeck (Eugène Bataille), was shown at the " Incoherents " show in Paris. In 1919, Marcel Duchamp, one of the most influential modern artists, created L.H.O.O.Q., a Mona Lisa parody made by adorning a cheap reproduction with a moustache and goatee. Duchamp added an inscription, which when read out loud in French sounds like "Elle a chaud au cul" meaning: "she has a hot ass", implying the woman in the painting is in a state of sexual excitement and intended as a Freudian joke. According to Rhonda R. Shearer, the apparent reproduction is in fact a copy partly modelled on Duchamp's own face.

Salvador Dalí, famous for his surrealist work, painted Self portrait as Mona Lisa in 1954. Andy Warhol created serigraph prints of multiple Mona Lisa s, called Thirty Are Better than One, following the painting's visit to the United States in 1963. The French urban artist known pseudonymously as Invader has created versions of the Mona Lisa on city walls in Paris and Tokyo using a mosaic style. A 2014 New Yorker magazine cartoon parodies the supposed enigma of the Mona Lisa smile in an animation showing progressively more maniacal smiles.