Effects of substance abuse. About 1 in 10 heavy drinkers will eventually develop cirrhosis. Opioids are some of the most habit-forming substances. 4 in 5 new heroin users started out misusing painkillers. Excessive consumption of alcohol and drugs can have long-lasting effects on the body such as becoming restless, paranoia, abdominal distention and bloating, respiratory depression, heavy brain damage among others