Pattern of ActivityAntibioticsGoal of TherapyPK/PD Parameter Type I Concentration- dependent killing and Prolonged persistent effects Aminoglycosides Daptomycin Fluoroquinolones Ketolides Maximize concentrations 24h-AUC/MIC Peak/MIC AUC/MIC > 100 Peak/MIC > 10 Type II Time-dependent killing and Minimal persistent effects Carbapenems Cephalosporins Erythromycin Linezolid Penicillins Maximize duration of exposure T>MIC T>MIC 40-50% Type III Time-dependent killing and Moderate to prolonged persistent effects.