document: cardiovascular disease ( cvd ) is the leading cause of death in the united states . in 2010 , cvds killed over 700 000 americans , and accounted for 29.4% of total deaths . 
   moreover , cvd accounts for a significant portion of the financial burden of medical care , costing > $ 312.6 billion in healthcare spending and lost productivity in 2010 . 
   aspirin therapy is a prevention measure that can reduce the risk of major cardiovascular events such as heart attack and stroke , and is recommended by the us preventive services task force to prevent heart attack and ischemic stroke . 
   aspirin is used as a primary prevention measure to aid in the prevention of a first occurrence of cvd . 
   it can also be used as a secondary prevention measure among individuals who have experienced a heart attack or stroke to prevent additional cardiovascular events . 
   the american heart association recommends the use of lowdose aspirin daily for people at high risk of a heart attack and regular use of lowdose aspirin for heart attack survivors . 
   a variety of studies have examined whether individuals at risk of having a heart attack in the united states were taking aspirin . however , many of these studies failed to ascertain whether a person was recommended to take aspirin by their physician or whether they were taking it on their own initiative . 
   thus , these studies may be not an accurate assessment of physician recommendations for aspirin use . 
   further , much of the past research has used various risk factors to determine whether people were at high risk of cvd , rather than using the framingham risk score ( frs ) as recommended by the us preventive services task force in 2009 , the 2010 american diabetes association / american heart association / american college of cardiology recommendations , and the 2008 american college of chest physician guidelines . 
   prevention of cvd events is particularly important , and understanding physician recommendations for aspirin therapy is critical for delivering quality health care . 
   our current understanding of who is being encouraged to take aspirin for cvd prevention is limited . 
   we sought to evaluate patient use of aspirin and reported physician recommendations of aspirin therapy for cvd prevention , in a nationally representative sample . 
   we analyzed the national health and nutrition examination survey ( nhanes ) for the years 20112012 . 
   the nhanes samples the noninstitutionalized population of the united states by using a stratified multistage probability sample design . 
   the national center for health statistics uses a multilevel weighting system to account for survey design and nonresponse . 
   the current study is focused on adults 40 years of age and older , because the nhanes asked this sequence of questions about aspirin use only to adults aged 40 and older . 
   the respondents were asked if their doctor recommended that they take lowdose aspirin for prevention of cvd , stroke , or cancer . 
   individuals who reported a recommendation to take aspirin were also asked if they were following this advice . 
   individuals who did not report a recommendation to take aspirin were asked if they were taking lowdose aspirin on their own . for the purposes of this analysis , 
   these individuals were combined with those who were taking aspirin on their physician 's recommendations , in order to get a better understanding of who is taking aspirin . 
   individuals who had never been told by a physician that they had a stroke or heart attack were considered candidates for primary prevention . 
   their eligibility for guidelinerecommended use of aspirin was based on the assessment of their risk for coronary heart disease ( chd ) . 
   high risk for chd was classified as having a 10year chd risk of > 10% according to the frs with no history of heart attack or stroke . 
   low risk for chd was considered a risk of 10% according to the frs with no history of heart attack or stroke as stated in the 2010 american diabetes association / american heart association / american college of cardiology guidelines . 
   the frs utilizes gender , age , total cholesterol , highdensity lipoprotein cholesterol , systolic blood pressure , use of blood pressure medications , and smoking status . for nhanes participants , 
   systolic blood pressure was calculated by averaging 3 readings taken during the medical examination portion of the nhanes . 
   the scores were grouped into 2 categories for this analysis : low risk ( having a 10 year risk of heart attack be < 10% on the framingham risk calculator ) and high risk ( 10% or above ) . for people with diabetes ( defined as having been told by a physician that the respondent had diabetes [ excluding gestational diabetes ] ) , as per the american diabetes association / american heart association / american college of cardiology guidelines , individuals scoring < 5% were considered low risk , and individuals scoring > 10% were considered high risk . 
   individuals with diabetes who had an intermediate risk score between 5% and 10% were removed from the analysis because there is no firm guideline for this group regarding aspirin use from the american diabetes association / american heart association / american college of cardiology guidelines . 
   we did , however , examine whether there were differences in being told to take aspirin and whether they were taking it , and how they compared to low and highrisk diabetes patients . 
   individuals who reported that a doctor had previously told them that they had been diagnosed with a stroke or a heart attack were candidates for secondary prevention . although obesity is not a specific characteristic that would justify a recommendation of aspirin for primary prevention , it is possible that both patients and physicians may interpret the cvd risk inherent in obesity as justifying aspirin . 
   the nhanes 20112012 does not ask questions regarding history of peptic ulcer or other gastrointestinal conditions that could increase risk of bleeding . 
   it does , however , collect information about stomach cancer , a condition for which aspirin use is contraindicated . to control for this , we removed individuals with a history of stomach cancer from the analysis . 
   age was selfreported and divided into 2 categories : 40 to 64 and 65 and older . race 
   / ethnicity was also selfreported and was categorized as nonhispanic whites , nonhispanic blacks , hispanics , and asians / other . 
   education was examined because of its potential impact on selfinitiation of aspirin use . as having access to care 
   may affect whether patients receive appropriate care for ambulatorysensitive conditions including diabetes and cvd , we examined both whether the respondent had health insurance and a regular source of health care . 
   insurance status was defined as whether or not the individual reported having health insurance , of any form , at the time of the interview . 
   regular access to care was defined by whether the respondent reported having a place to regularly go to receive health care . 
   the nhanes uses a stratified multistage probability sample design . to account for this complex design 
   the analysis utilized the nesting capability in sudaan with variables provided in nhanes ( that account for stratum level differences and primary sampling unit differences ) for all analysis , along with the appropriate weight identified by national center for health statistics for the type of data being used in our analysis . 
   utilizing these weights and sampling design variables allows us to account for the complexity of the sampling design in performing univariate analyses ,  tests , and logistic regression models and make population estimates for the noninstitutionalized adult population of the united states . 
   we examined obesity status , demographics , and access to care characteristics of the respondents . 
   we also examined the bivariate relationship between being told to take aspirin / taking aspirin on doctor 's orders / taking aspirin on their own with the individual 's high / low risk for chd based on frs / previous diagnosis of diabetes using  tests to test for significant differences . 
   we examined both primary prevention ( those who have not been told by their physician that they have had either a stroke and/or heart attack ) and secondary prevention ( have been told by their physician that they have had either a heart attack or stroke ) . 
   we examined the bivariate relationship between being told to take aspirin and taking aspirin with risk level using  tests to test for significant differences . 
   we also conducted separate analyses stratified by race using  tests to examine the impact of race on other independent variables as well as on the outcome variables . 
   bivariate estimates for stratifying secondary prevention by heart attack or stroke were examined , but the sample size was too small for stratified estimates to produce reliable estimates . 
   all bivariate calculations used the standard method of pairwise deletion to account for missing data . 
   we computed forcedinclusion logistic regression to examine the relationship of risk status , age , gender , race , education level , obesity status , having insurance , and having a regular source of care on the likelihood of whether patients were told to take aspirin by their physicians . 
   we conducted the regression for the primary prevention sample and again separately for individuals at high and low risk . 
   we were unable to conduct logistic regressions for individual racial / ethnic groups because the sample size was too small to generate reliable estimates . 
   we also conducted tests for multicollinearity of risk status ( based on the frs ) with obesity , age , and gender . 
   specifically , we computed spearman 's correlations as well as examined the tolerance and variance inflation factors of independent variables in the regressions 
   . the frs uses gender and age as variables in its construction , and obesity is a known risk factor for cvd . 
   the respondents were asked if their doctor recommended that they take lowdose aspirin for prevention of cvd , stroke , or cancer . 
   individuals who reported a recommendation to take aspirin were also asked if they were following this advice . 
   individuals who did not report a recommendation to take aspirin were asked if they were taking lowdose aspirin on their own . for the purposes of this analysis , 
   these individuals were combined with those who were taking aspirin on their physician 's recommendations , in order to get a better understanding of who is taking aspirin . 
   individuals who had never been told by a physician that they had a stroke or heart attack were considered candidates for primary prevention . 
   their eligibility for guidelinerecommended use of aspirin was based on the assessment of their risk for coronary heart disease ( chd ) . 
   high risk for chd was classified as having a 10year chd risk of > 10% according to the frs with no history of heart attack or stroke . 
   low risk for chd was considered a risk of 10% according to the frs with no history of heart attack or stroke as stated in the 2010 american diabetes association / american heart association / american college of cardiology guidelines . 
   the frs utilizes gender , age , total cholesterol , highdensity lipoprotein cholesterol , systolic blood pressure , use of blood pressure medications , and smoking status . for nhanes participants , 
   systolic blood pressure was calculated by averaging 3 readings taken during the medical examination portion of the nhanes . 
   the scores were grouped into 2 categories for this analysis : low risk ( having a 10 year risk of heart attack be < 10% on the framingham risk calculator ) and high risk ( 10% or above ) . 
   for people with diabetes ( defined as having been told by a physician that the respondent had diabetes [ excluding gestational diabetes ] ) , as per the american diabetes association / american heart association / american college of cardiology guidelines , individuals scoring < 5% were considered low risk , and individuals scoring > 10% were considered high risk . 
   individuals with diabetes who had an intermediate risk score between 5% and 10% were removed from the analysis because there is no firm guideline for this group regarding aspirin use from the american diabetes association / american heart association / american college of cardiology guidelines . 
   we did , however , examine whether there were differences in being told to take aspirin and whether they were taking it , and how they compared to low and highrisk diabetes patients . 
   individuals who reported that a doctor had previously told them that they had been diagnosed with a stroke or a heart attack were candidates for secondary prevention . 
   although obesity is not a specific characteristic that would justify a recommendation of aspirin for primary prevention , it is possible that both patients and physicians may interpret the cvd risk inherent in obesity as justifying aspirin . 
   the nhanes 20112012 does not ask questions regarding history of peptic ulcer or other gastrointestinal conditions that could increase risk of bleeding . 
   it does , however , collect information about stomach cancer , a condition for which aspirin use is contraindicated . to control for this , we removed individuals with a history of stomach cancer from the analysis . 
   age was selfreported and divided into 2 categories : 40 to 64 and 65 and older . race 
   / ethnicity was also selfreported and was categorized as nonhispanic whites , nonhispanic blacks , hispanics , and asians / other . 
   education was examined because of its potential impact on selfinitiation of aspirin use . as having access to care 
   may affect whether patients receive appropriate care for ambulatorysensitive conditions including diabetes and cvd , we examined both whether the respondent had health insurance and a regular source of health care . 
   insurance status was defined as whether or not the individual reported having health insurance , of any form , at the time of the interview . 
   regular access to care was defined by whether the respondent reported having a place to regularly go to receive health care . 
   the nhanes uses a stratified multistage probability sample design . to account for this complex design 
   the analysis utilized the nesting capability in sudaan with variables provided in nhanes ( that account for stratum level differences and primary sampling unit differences ) for all analysis , along with the appropriate weight identified by national center for health statistics for the type of data being used in our analysis . 
   utilizing these weights and sampling design variables allows us to account for the complexity of the sampling design in performing univariate analyses ,  tests , and logistic regression models and make population estimates for the noninstitutionalized adult population of the united states . 
   we examined obesity status , demographics , and access to care characteristics of the respondents . 
   we also examined the bivariate relationship between being told to take aspirin / taking aspirin on doctor 's orders / taking aspirin on their own with the individual 's high / low risk for chd based on frs / previous diagnosis of diabetes using  tests to test for significant differences . 
   we examined both primary prevention ( those who have not been told by their physician that they have had either a stroke and/or heart attack ) and secondary prevention ( have been told by their physician that they have had either a heart attack or stroke ) . 
   we examined the bivariate relationship between being told to take aspirin and taking aspirin with risk level using  tests to test for significant differences . 
   we also conducted separate analyses stratified by race using  tests to examine the impact of race on other independent variables as well as on the outcome variables . 
   bivariate estimates for stratifying secondary prevention by heart attack or stroke were examined , but the sample size was too small for stratified estimates to produce reliable estimates . 
   all bivariate calculations used the standard method of pairwise deletion to account for missing data . 
   we computed forcedinclusion logistic regression to examine the relationship of risk status , age , gender , race , education level , obesity status , having insurance , and having a regular source of care on the likelihood of whether patients were told to take aspirin by their physicians . 
   we conducted the regression for the primary prevention sample and again separately for individuals at high and low risk . 
   we were unable to conduct logistic regressions for individual racial / ethnic groups because the sample size was too small to generate reliable estimates . 
   we also conducted tests for multicollinearity of risk status ( based on the frs ) with obesity , age , and gender . 
   specifically , we computed spearman 's correlations as well as examined the tolerance and variance inflation factors of independent variables in the regressions 
   . the frs uses gender and age as variables in its construction , and obesity is a known risk factor for cvd . 
   a total of 3435 individuals answered questions about aspirin use , representing 142 677 272 americans . 
   demographic characteristics of the sample , primary prevention group , lowrisk primaryprevention group , and highrisk primaryprevention group are shown in table 1 . 
   characteristics of individuals eligible for primary prevention , individuals at high risk , and individuals at low risk na indicates not applicable . 
   table 1 shows that among the total sample eligible for aspirin as primary prevention , less than a third reported being recommended by their doctor to take aspirin . 
   table 1 also indicates that over three fourths of primaryprevention patients were classified as low risk . 
   less than half of the primaryprevention patients who had a high chd risk level received a recommendation to take aspirin while > one fourth of lowrisk patients were also recommended to take aspirin ( table 1 ) . 
   of those told to take aspirin by their physicians , the vast majority complied with the recommendation . specifically , 77.4% of the total sample , 79.0% of the highrisk patients , and 76.5% of the lowrisk patients reported taking aspirin ( table 1 ) . 
   table 2 shows the bivariate relationships between the demographic variables , health insurance , having a regular place to go for health care , and having a diabetes diagnosis and being told by the physician to take aspirin as primary prevention . 
   analysis examining differences between low , intermediate , and highrisk diabetes showed that among lowrisk diabetes patients , 54.6% were told to take aspirin , compared to 72.8% of intermediaterisk diabetes patients and 56.2% of highrisk diabetes patients ( p = 0.17 ) . 
   bivariate results for patients told to take aspirin , for individuals eligible for primary prevention , individuals at high risk , and individuals at low risk table 3 presents bivariate relationships among respondents who were taking aspirin after having received a recommendation to do so by their physician . in an additional subanalysis 
   , there were no statistically significant differences for taking aspirin for low , intermediate , and highrisk diabetes patients , with 51.5% of lowrisk diabetes patients taking aspirin , 42.2% of intermediaterisk diabetes patients taking aspirin , and 47.1% highrisk diabetes patients taking aspirin ( p = 0.53 ) . 
   bivariate results for taking aspirin among respondents told by their physicians to take aspirin , for individuals eligible for primary prevention there were a number of significant differences in demographic and accesstocare variables by race / ethnic group among primaryprevention patients , as shown in table 4 . 
   bivariate results for demographic differences by race , for individuals eligible for primary prevention of the 8.3% of the total sample eligible for secondary prevention , 75.9% were told to take aspirin by their physician . of those who were told by their physicians to take aspirin , 
   table 5 shows the results of 3 logistic regression models for being told to take aspirin among individuals eligible for primary prevention , only individuals at high risk , and only individuals at low risk . 
   the logistic regression examining all patients without a history of heart attack or stroke that included risk level as an independent variable indicated that the frs was not predictive of receiving a physician recommendation for aspirin . among all primaryprevention patients , education level , insurance status , and having a regular source of care were predictive of receiving a recommendation for aspirin for cvd prevention . among highrisk individuals , age , health insurance , and being of asian / other descent were predictive of receiving a recommendation for aspirin for cvd prevention . among lowrisk individuals , age , health insurance status , education level , and obesity status were all predictive of receiving a recommendation for aspirin therapy . 
   logistic regression results predicting aspirin recommendation for individuals eligible for primary prevention , individuals at high risk , and individuals at low risk or indicates odds ratio . 
   table 1 shows that among the total sample eligible for aspirin as primary prevention , less than a third reported being recommended by their doctor to take aspirin . 
   table 1 also indicates that over three fourths of primaryprevention patients were classified as low risk . 
   less than half of the primaryprevention patients who had a high chd risk level received a recommendation to take aspirin while > one fourth of lowrisk patients were also recommended to take aspirin ( table 1 ) . of those told to take aspirin by their physicians , the vast majority complied with the recommendation . 
   specifically , 77.4% of the total sample , 79.0% of the highrisk patients , and 76.5% of the lowrisk patients reported taking aspirin ( table 1 ) . 
   table 2 shows the bivariate relationships between the demographic variables , health insurance , having a regular place to go for health care , and having a diabetes diagnosis and being told by the physician to take aspirin as primary prevention . 
   analysis examining differences between low , intermediate , and highrisk diabetes showed that among lowrisk diabetes patients , 54.6% were told to take aspirin , compared to 72.8% of intermediaterisk diabetes patients and 56.2% of highrisk diabetes patients ( p = 0.17 ) . 
   bivariate results for patients told to take aspirin , for individuals eligible for primary prevention , individuals at high risk , and individuals at low risk 
   table 3 presents bivariate relationships among respondents who were taking aspirin after having received a recommendation to do so by their physician . in an additional subanalysis 
   , there were no statistically significant differences for taking aspirin for low , intermediate , and highrisk diabetes patients , with 51.5% of lowrisk diabetes patients taking aspirin , 42.2% of intermediaterisk diabetes patients taking aspirin , and 47.1% highrisk diabetes patients taking aspirin ( p = 0.53 ) . 
   bivariate results for taking aspirin among respondents told by their physicians to take aspirin , for individuals eligible for primary prevention 
   there were a number of significant differences in demographic and accesstocare variables by race / ethnic group among primaryprevention patients , as shown in table 4 . 
   of the 8.3% of the total sample eligible for secondary prevention , 75.9% were told to take aspirin by their physician . 
   of those who were told by their physicians to take aspirin , 89.9% were taking aspirin . 
   table 5 shows the results of 3 logistic regression models for being told to take aspirin among individuals eligible for primary prevention , only individuals at high risk , and only individuals at low risk . 
   the logistic regression examining all patients without a history of heart attack or stroke that included risk level as an independent variable indicated that the frs was not predictive of receiving a physician recommendation for aspirin . among all primaryprevention patients , education level , insurance status , and having a regular source of care were predictive of receiving a recommendation for aspirin for cvd prevention . among highrisk individuals , age , health insurance , and being of asian / other descent were predictive of receiving a recommendation for aspirin for cvd prevention . among lowrisk individuals , age , health insurance status , education level , and obesity status were all predictive of receiving a recommendation for aspirin therapy . 
   logistic regression results predicting aspirin recommendation for individuals eligible for primary prevention , individuals at high risk , and individuals at low risk or indicates odds ratio . 
   the results of this study indicate that recommendations for aspirin for cvd prevention do not match up to the objectively computed future risk . for individuals at high risk , fewer than half report receiving recommendations for aspirin . 
   moreover , in a multivariate analysis , objective risk level was not associated with an increased risk of recommendation for aspirin . 
   this suggests that decisions for treatment recommendations seem to be being made on criteria other than objectively calculated future chd risk . 
   only 40.9% of patients at high risk reported having been told by their physician to take aspirin . 
   patient reports of recommendations for aspirin use among secondary prevention patients was 75.9% , but still suboptimal . 
   respondents who were at low risk of developing cvd and had body mass indexes over 30 were more likely to be told to take aspirin for primary prevention than normalweight patients . 
   the benefit of using aspirin in lowrisk patients who do not have clinical cvd is negated by the risk of harms from gastrointestinal bleeding . 
   it is possible that the seemingly suboptimal rates of recommendations to take lowdose aspirin are the result of the provider weighing the benefits of aspirin against the very real risks of upper gastrointestinal bleeding . 
   lin et al have shown that the risk of upper gastrointestinal bleeding is 90% higher among lowdose aspirin users who are using aspirin for primary prevention compared to nonusers and 40% higher for secondaryprevention patients . 
   the number needed to harm per 1 year of lowdose aspirin use was 601 for primaryprevention patients and 391 for secondaryprevention patients . 
   patients with a history of upper gastrointestinal bleeding and peptic ulcers also have a higher incidence of upper gastrointestinal bleeding , as do patients with concomitant use of clopidogrel or nonsteroidal antiinflammatory drugs . 
   all of these factors may have contributed to the lack of recommendations for aspirin use to highrisk patients . 
   first , nhanes does not account for hemorrhagic stroke ( 13% of all strokes ) and aspirin use would be inappropriate for these patients . 
   second , secondaryprevention patients could be taking other blood thinners that would obviate the need for lowdose aspirin . in order to better understand physician prescribing practices of aspirin and patient usage of aspirin , additional research of aspirin use in the context of other antiplatelet and anticoagulant use 
   the apparent disconnect between risk for future cvd and aspirin recommendations may benefit from improved clinical decision support . helping to compute 
   the actual risk rather than simply identifying general risk factors should aid in making accurate decisions . 
   actual risk could be computed in electronic health records , which could also provide the physician with the recommendation for treatment . 
   in addition , such tools could provide other affiliated treatment recommendations such as use of gastricprotective agents in select patient populations . 
   in addition to a significant disconnect between who needs and who receives recommendations for aspirin use , the analysis indicated a persistent problem with access to care and receipt of recommendations for aspirin use . 
   lack of health insurance can be a significant barrier to accessing health care , especially for preventive services . 
   previous research has found no relationship between insurance status and aspirin use among patients who accessed clinical preventive services . 
   these results suggest that access to care may play a role in recommendations for the advice of aspirin for cvd prevention , and the use of it by patients 
   . the present results may differ from previous studies in that the previous studies did not assess whether the provider recommended aspirin for cvd prevention . 
   race and ethnicity did have an impact among primaryprevention patients , with nonhispanic whites more likely to receive a recommendation for aspirin than were asians / others . 
   additional analyses indicated that among primaryprevention patients , a greater percentage of nonhispanic whites had health insurance compared with other racial / ethnic groups . 
   as with curative medical care , the ability to access preventive medical care is in large part influenced by insurance status . 
   therefore , part of the racial / ethnic disparities in primary prevention that we observed are possibly attributable to lack of health insurance and a usual source of care . that a higher level of education for primaryprevention and lowrisk patients was predictive of lower likelihood of receiving a recommendation for aspirin was somewhat surprising , particularly that the finding emerged after controlling for race , age , gender , obesity , insurance status , and access to a regular source of care . 
   it is possible that physicians may perceive more highly educated people as having a lower risk of heart disease , based on the known connection between educational attainment and health outcomes . 
   this investigation relies on selfreport of whether or not an individual 's doctor recommended aspirin as prevention of heart attack , stroke , and cancer , as well as selfreport of a number of variables for analysis . 
   selfreported data are very common in studies of health behaviors , but there are questions regarding the reliability of the data . 
   patient selfreport can be unreliable , especially regarding behaviors and risk factors relevant to cvd and cancer . 
   the national center for health statistics conducts rigorous testing of its survey instruments to ensure validity through the questionnaire design research laboratory , ensuring that all questions utilized are of high reliability and validity . 
   in addition , lab and physical examination values were used when possible to minimize bias introduced by selfreport . 
   an additional limitation is that the study only examines adults age 40 and over , as this is the only group that nhanes asks about aspirin use 
   . there could be important patterns of use among younger individuals that this analysis can not look for . 
   another limitation of this study is that we do not know how many respondents were recommended to take aspirin for heart attack or stroke prevention versus for cancer prevention . 
   thus , it is possible that some proportion of aspirin recommendations may be for cancer prevention , rather than heart attack or stroke prevention . 
   however , the us preventive services task force currently recommends against the use aspirin for the prevention of cancer , thereby suggesting that recommendations to take aspirin based on cancer prevention should be unlikely . 
   in addition , this study did not control for use of warfarin or other anticoagulant / antiplatelet therapy among respondents . 
   anticoagulant use could explain some of the deficit in the use and recommendations to take aspirin among primaryprevention patients . finally , 
   because of limitations in what information is collected by the nhanes , we do not know what role the risk of gastrointestinal bleeding played in the decision of physicians to recommend aspirin . 
   gastrointestinal bleeding is a significant issue that we would expect to have an impact on the likelihood of a physician recommending aspirin use for patients who may otherwise benefit from it . 
   the available data from nhanes do not allow us to elucidate who is at greater risk for gastrointestinal bleeding and for whom a recommendation to take aspirin would be inappropriate . 
   highrisk patients who are not receiving the recommendation are put at increased risk of cvd events . 
   lowrisk patients are exposed to adverse risk with unnecessary use of aspirin based upon a physician 's recommendation . 
   it is clear that quality of care for primary prevention falls far short of ideal . 
   further research on clinical decision support systems and interventions designed to reinforce the use of appropriate risk calculation is necessary to ensure that patients receive appropriate preventive care .
summary: backgroundaspirin use has been shown to be an effective tool in cardiovascular disease ( cvd ) prevention among highrisk patients . 
   the patientreported physician recommendation for aspirin as preventive therapy among high and lowrisk patients is unknown.methods and resultswe conducted an analysis of the national health and nutrition examination survey 20112012 to examine the use of aspirin for cvd prevention . 
   patients without previously diagnosed cvd were classified into high and low risk based on their framingham risk score ( 10year coronary heart disease risk ) . among patients without previously diagnosed cvd , 
   22.5% were classified as high risk . of the highrisk individuals , 
   40.9% reported being told by their physician to take aspirin , with 79.0% complying . among those who were at low risk , 
   26.0% were told by their physician to take aspirin , with 76.5% complying . 
   logistic regression analysis indicated that age , access to a regular source of care , education , and insurance status were significant predictors of patientreported physician recommendations for aspirin use for primary prevention . among highrisk patients , age , race , and insurance status were significant predictors of reported recommendations for aspirin use . among lowrisk patients , age , education , obesity , and insurance status were significant predictors of reported recommendations for aspirin use.conclusionspatient reports indicate nonideal rates of being told to take aspirin , for both high and lowrisk patients for primary prevention . 
   clinical decision support tools that could assist physicians in identifying patients at risk may increase patient reports of physician recommendations for aspirin use .