document: the incidence of hypotension in non - obstetric patients ranges between 5% and 66% , depending on the definition of hypotension limit , timing of measurements , and differences between data acquisition methods and patient characteristics . 
   previous cohort studies reported that hypotension due to spinal anesthesia was approximately twice as common in hypertensive patients [ 13 ] . 
   it has been shown that intraoperative hypotension is associated with myocardial ischemia and increased stroke risk . 
   in addition , because hypertension is an independent risk factor for coronary heart disease , congestive heart failure , and cerebrovascular diseases , it is considered that the negative effects of hypotension will occur more easily in this patient group . 
   the number of hypertensive patients in the adult population in turkey is estimated to be approximately 15 million ( 31.8% ) , and almost one - third is unaware of their condition . 
   although hypertension is a problem frequently encountered by anesthesiologists , and despite advances in the definition and management of hypertension , there are only a few randomized controlled studies that have investigated the hemodynamic effects of spinal anesthesia in these patients . in this study we aimed to compare normotensive patients and hypertensive patients under control by medical treatment , with respect to the hemodynamic effects of spinal anesthesia performed with hyperbaric bupivacaine . 
   the study was approved by the ethics committee of haseki training and research hospital , and all patients gave written and verbal consent prior to the study . 
   sixty patients ages 1865 with asa scores i  ii and who were scheduled for elective surgeries of lower abdomen , lower limbs , and perineum under spinal anesthesia were included into the study . 
   blood pressures and heart rates were measured under standard conditions and the basal values were recorded . 
   patients with a history of hypertension and who regularly used antihypertensive medications constituted group h ( n=30 ) , and patients with basal blood pressure values below 140/90 mm hg and no history of use of drugs effective on the cardiovascular system constituted group n ( n=30 ) . 
   hypertension was inadequately controlled but blood pressure was below 180/100 mm hg in all patients of group h. antihypertensive drugs were given on the morning of surgery . 
   patients in whom lumbar puncture failed in the first attempt , who had blood loss necessitating transfusion , or had any contraindications against spinal anesthesia were excluded from the study . 
   an intravenous catheter was placed in the premedication room , then the ecg , non - invasive blood pressure ( nibp ) and peripheral oxygen saturation ( spo2 ) were monitored ( drger infinity delta , drger medical systems , inc . 
   the patients were premedicated with 11.5 mg midazolam and received 10 ml / kg isotonic nacl according to the ideal body mass calculated with formula ( [ height100 ( height150)/4 ] for male and [ height100 ( height150)/4]0.9 for female ) in 20 minutes , then they were taken into the operating room . spinal anesthesia injected with a 22-gauge quincke spinal needle from the l34 intervertebral space with the patient in sitting position . as the local anesthetic , 3.5 ml of 0.5% hyperbaric bupivacaine ( marcaine 0.5% , spinal heavy 0.5% ( 5 
   mg / ml ) astrazeneca ) was applied to the subarachnoid space for 15 seconds . 
   the patients were then immediately brought into supine position with the head elevated to 30 degrees . 
   sensory block was evaluated with the pinprick test , and motor block was evaluated with the modified bromage scale ( 0=no motor block , 1=inability to raise extended leg , but able to move knees and feet , 2=inability to raise extended leg and move knee , but able to move feet , 3=inability to flex ankle joint ) . 
   the systolic ( sbp ) , diastolic ( dbp ) , and mean ( mbp ) blood pressures , and heart rate ( hr ) were measured and recorded by an assistant at the following time points : basal ( the average of 3 consecutive measurements in the premedication room ) , after fluid loading , and 1 , 3,5 , 10 , 20 , 30 , 40 , 50 , and 60 minutes after spinal anesthesia . 
   a decrease of mbp of more than 30% from the baseline was accepted as hypotension and was treated with intravenous ephedrine 5 mg . 
   a decrease in hr to below 50 beats / minute was accepted as bradycardia and was treated with intravenous atropine 0.5 mg . 
   patients who received ephedrine and atropine , and the time of treatment were recorded . during surgery 
   , all patients inspired 100% o2 at a flow rate of 2 l / minute using a face mask , and isotonic nacl was infused at 8 ml / kg / hour . 
   data were evaluated with the spss 17.0 statistics software for windows ( spss inc . , 
   categoric variables between the groups ( sex , asa , the frequency of hypotension and bradycardia ) were compared with the chi - square test . 
   numeric variables ( sex , body weight , height , and hemodynamic parameters ) were evaluated with the kolmogorov - smirnov test with respect to normal distribution . 
   repeated measurements analysis of variance ( rmanova ) was used for intragroup comparison of the hemodynamic data , and bonferroni test was used for post hoc multiple comparison . 
   the data are shown as mean s.d . and p<0.05 was accepted as statistically significant . 
   there was no significant difference between the groups with respect to age , sex , weight , height , maximal height of sensory block , incidences of hypotension and bradycardia , or the amount of fluids infused ( p>0.05 ) . 
   however , in group h the number of patients with asa ii physiologic scores was statistically higher compared to group n ( p<0.001 ) ( table 1 ) . 
   antihypertensive medications used by the patients are also shown in table 1 . in the hypertensive patient group , 
   the sbp , dbp , and mbp values were significantly higher than the normotensive patient group at all measurement times ( p<0.05 ) . 
   comparison within the groups did not reveal any significant differences in either group compared to the basal values ( p>0.05 ; figures 13 ) . 
   we also found that hr values did not show a significant change compared to the basal measurements ( p>0.05 ; figure 4 ) . 
   six patients in group h and 7 patients in group n received atropine due to bradycardia . 
   we observed that bradycardia resolved with a single dose of 0.5 mg intravenous atropine . in patients who developed hypotension , a single dose of 5 mg ephedrine treatment was sufficient ( table 1 ) . 
   in this study we showed that there was no difference between the incidence of hypotension in hypertensive versus normotensive patients who underwent spinal anesthesia with hyperbaric bupivacaine . 
   however , the number of patients who developed hypotension was greater in the hypertensive group ( 6/30 ) compared to the normotensive group ( 1/30 ) . in contrast to our results , racle et al 
   .   reported that hypotension due to spinal anesthesia with 0.5% isobaric bupivacaine was more frequent in hypertensive patients than in normotensives . in their study , the incidence rate of hypotension was 33% ( 10 out of 30 patients ) in the hypertensive group and 10% ( 3 out of 30 patients ) in the normotensive group , which were higher than our results . on the other hand , 2 other studies showed , as in our study , that the incidence rates of hypotension in hypertensive and normotensive patient groups were not different . 
   however , the rates of hypotension were 55.5% and 67% in hypertensive patients , and 43.8% and 73% in normotensive patients , which were higher than our findings . 
   the patients in the studies of racle   and nishikawa   were 1 or 2 decades older than ours ( mean age was above 75 ) . 
   hypotension due to spinal anesthesia is caused by decreased systemic vascular resistance and venous return to the heart , caused by sympathetic system blockage . 
   there is an increase in the basal sympathetic system activity and plasma norepinephrine levels associated with aging . 
   therefore , sympathetic blockage after spinal anesthesia may cause a greater decrease in the systemic vascular resistance in elderly patients . 
   hypertensive patients also have increased sympathetic activity and norepinephrine levels , as well as decreased parasympathetic activity . 
   persistent sympathetic stimulation , independent of hypertension itself , causes loss of elasticity in the arterial wall and induces structural changes that in turn result in increases in peripheral vascular resistance . 
   it has been shown that there is a close relationship between basal sympathetic activity and decrements in blood pressure that occur after sympathetic blockage . 
   the reduction in blood pressure after spinal anesthesia is correlated with the degree of preoperative blood pressure . 
   fukuda   and nishikawa   found that when preoperative blood pressure was normalized with antihypertensive treatment , there was no difference between the incidence of hypotension following spinal anesthesia in hypertensive versus normotensive patients . 
   our results support these findings  the reason for this is the improvement in vascular structural changes and the achievement of a decrease in basal sympathetic activity with the use of effective antihypertensive treatment . 
   prehydration under the guidance of heart rate variability , an indicator of sympathovagal balance , was seen to decrease the risk of hypotension after spinal anesthesia . 
   venous capacitance is decreased in hypertensive patients ; therefore it is thought that a sympathetic block after spinal anesthesia will cause a further decrease in the central volume and venous return to the heart . 
   the fact that antihypertensive treatment provides an improvement in venous capacitance as much as peripheral vascular resistance explains why we did not find any significant decrease in the incidence of hypotension between normotensive and hypotensive patients . in this study , although we showed that there was no difference between the 2 groups with respect to the frequency of hypotension , the sbp , dbp , and mbp were higher in hypertensive patients compared to normotensive patients at all measurement times  this is related to the higher basal blood pressure values in the hypertensive group compared to the normotensive group . 
   our study did not measure the basal sympathetic activities of the patients , which is this study s most significant limiting factor . 
   although an improvement in this increase and blood pressure regulation is achieved with appropriate antihypertensive treatment , lack of measurement of the basal sympathetic activities of the patients was the most significant limiting factor . 
   in conclusion , we found that there was no significant difference between normotensive and hypertensive patients in the incidence of hypotension caused by spinal anesthesia with 0.5% hyperbaric bupivacaine .
summary: backgroundhypotension is the most common problem with spinal anesthesia . 
   this prospective study aimed to compare normotensive and hypertensive patients with respect to the hemodynamic effects of spinal anesthesia performed with hyperbaric bupivacaine.material/methodssixty patients who were scheduled to undergo various elective operations under spinal anesthesia were included into the study . 
   the patients were separated into 2 groups : hypertensive patients constituted group h ( n=30 ) and normotensive patients constituted group n ( n=30 ) . after fluid loading , spinal anesthesia was performed with 3.5 ml 0.5% hyperbaric bupivacaine . 
   demographic characteristics and incidence of hypotension and bradycardia were compared . 
   systolic ( sbp ) , diastolic ( dbp ) , and mean blood pressures ( mbp ) and heart rate ( hr ) were also compared before and after spinal anesthesia.resultsthere was no significant difference between the groups with respect to demographic characteristics , maximal height of sensory block , incidences of hypotension and bradycardia , and the amount of fluids infused ( p>0.05 ) . in the hypertensive patient group , 
   the sbp , dbp , and mbp values were significantly higher than in the normotensive patient group at all measurement times ( p<0.05 ) . 
   comparison within the groups did not reveal any significant differences in either group compared to the basal values ( p>0.05 ) . 
   there were no significant differences in hr between or within groups ( p>0.05).conclusionsthere was no significant difference between normotensive and hypertensive patients in the incidences of hypotension caused by spinal anesthesia with 0.5% hyperbaric bupivacaine .