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{"componentChunkName":"component---src-templates-tag-template-js","path":"/author/wan-y","result":{"data":{"site":{"siteMetadata":{"title":"Bioinformatics Institute Publications","subtitle":"Repository of all published Science Articles by our Researchers, their Group Members and Collaborators."}},"allMarkdownRemark":{"edges":[{"node":{"fields":{"slug":"/posts/2020-02-04-a-novel-method-for-the-capture-based-purification-of-whole-viral-native-rna-genomes/"},"frontmatter":{"title":"A novel method for the capture-based purification of whole viral native RNA genomes","date":"2019-05-08T09:21:35.165Z","categories":["Protein Sequence Analysis","Biomolecular Function Discovery Division "],"description":"Current technologies for targeted characterization and manipulation of viral RNA primarily involve amplification or ultracentrifugation with isopycnic gradients of viral particles to decrease host RNA background. The former strategy is non-compatible for characterizing properties innate to RNA strands such as secondary structure, RNA-RNA interactions, and also for nanopore direct RNA sequencing involving the sequencing of native RNA strands. "}}},{"node":{"fields":{"slug":"/posts/2020-02-27-structure-mapping-of-dengue-and-zika-viruses-reveals-functional-long-range-interactions/"},"frontmatter":{"title":"Structure mapping of dengue and Zika viruses reveals functional long-range interactions","date":"2019-03-29T07:30:07.749Z","categories":["Function and Structure of RNA","Biomolecular Function Discovery Division ","Multiscale Simulation, Modelling and Design","Biomolecular Modelling and Design Division"],"description":"Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus function. Here, we perform structure and interaction mapping on four DENV and ZIKV strains inside virions and in infected cells. Comparative analysis of SHAPE reactivities across serotypes nominates potentially functional regions that are highly structured, conserved, and contain low synonymous mutation rates. "}}}]}},"pageContext":{"tag":"Wan Y","currentPage":0,"postsLimit":8,"postsOffset":0,"prevPagePath":"/author/wan-y","nextPagePath":"/author/wan-y/page/1","hasPrevPage":false,"hasNextPage":false}}}