Interstate 78 runs southwest of Cetronia prior to its merge with PA Route 309. Interstate 476, the Northeast Extension of the Pennsylvania Turnpike, forms the informal boundary between this area and the Kuhnsville area just to the west. US 22, the Lehigh Valley Thruway, runs north of Cetronia, forming an informal boundary with the Crackersport and Walbert area to the north. I-476 has an interchange with US 22 at the western edge of Cetronia, which uses the Allentown zip code of 18104.