The second round (play-offs) will be contested by the ten group runners-up and the best two Nations League group winners, based on the Nations League overall ranking, who finished outside the top two of their qualifying group. They will be separated into three play-off paths, with each path featuring two single-leg semi-finals and one single-leg final. The semi-finals will be hosted by the six best-ranked runners-up of the qualifying group stage, while the host of the final will be determined by a draw. The semi-finals will be played on 24 March, and the finals on 29 March 2022. The winners of each path will qualify for the World Cup.