chunk: After the McManus brothers, Connor and Murphy, and their father, Noah (a.k.a. "Il Duce"), assassinated Joe Yakavetta, they fled to Ireland. Eight years later, their uncle Father Sibeal arrives to inform them that a renowned Boston priest was murdered by a mysterious assassin who attempted to frame the Saints by using their ritual assassination style. In response, the brothers dig up their old gear and weapons and depart for the United States.
  En route to Boston aboard a container ship, the brothers meet a Mexican underground fighter named Romeo, who recognizes them as the Saints. Romeo convinces them to let him join them as their new partner. Hearing a radio broadcast regarding Joe's son, Concezio Yakavetta, they deduce that he must have hired the hit-man who killed the priest in order to draw them out of hiding.