text: We present a novel method to explicitly incorporate topological prior knowledge into deep learning based segmentation, which is, to our knowledge, the first work to do so. Our method uses the concept of persistent homology, a tool from topological data analysis, to capture high-level topological characteristics of segmentation results in a way which is differentiable with respect to the pixelwise probability of being assigned to a given class. The topological prior knowledge consists of the sequence of desired Betti numbers of the segmentation. As a proof-of-concept we demonstrate our approach by applying it to the problem of left-ventricle segmentation of cardiac MR images of 500 subjects from the UK Biobank dataset, where we show that it improves segmentation performance in terms of topological correctness without sacrificing pixelwise accuracy.
  @cite_2: Regularization plays a crucial role in supervised learning. A successfully regularized model strikes a balance between a perfect description of the training data and the ability to generalize to unseen data. Most existing methods enforce a global regularization in a structure agnostic manner. In this paper, we initiate a new direction and propose to enforce the structural simplicity of the classification boundary by regularizing over its topological complexity. In particular, our measurement of topological complexity incorporates the importance of topological features (e.g., connected components, handles, and so on) in a meaningful manner, and provides a direct control over spurious topological structures. We incorporate the new measurement as a topological loss in training classifiers. We also propose an efficient algorithm to compute the gradient. Our method provides a novel way to topologically simplify the global structure of the model, without having to sacrifice too much of the flexibility of the model. We demonstrate the effectiveness of our new topological regularizer on a range of synthetic and real-world datasets.
summary: The recent work of @cite_2 introduced a topological regulariser for classification problems by considering the stability of connected components of the classification boundary and can be extended to higher-order topological features. It also provided a differentiable loss function which can be incorporated in the training of a neural network. This approach differs from ours in that firstly, it imposes topological constraints on the shape of the classification boundary in the feature space of inputs to the network, rather than topological constraints in the space of the pixels in the image, and secondly it aims only to reduce overall topological complexity. Our approach aims to fit the desired absence or presence of certain features and so complex features can be penalised or rewarded, as is appropriate for the task at hand.