text: Adversarial training has been recently employed for realizing structured semantic segmentation, in which the aim is to preserve higher-level scene structural consistencies in dense predictions. However, as we show, value-based discrimination between the predictions from the segmentation network and ground-truth annotations can hinder the training process from learning to improve structural qualities as well as disabling the network from properly expressing uncertainties. In this paper, we rethink adversarial training for semantic segmentation and propose to formulate the fake real discrimination framework with a correct incorrect training objective. More specifically, we replace the discriminator with a "gambler" network that learns to spot and distribute its budget in areas where the predictions are clearly wrong, while the segmenter network tries to leave no clear clues for the gambler where to bet. Empirical evaluation on two road-scene semantic segmentation tasks shows that not only does the proposed method re-enable expressing uncertainties, it also improves pixel-wise and structure-based metrics.
  @cite_30: In this paper, we propose perceptual adversarial networks (PANs) for image-to-image transformations. Different from existing application driven algorithms, PAN provides a generic framework of learning to map from input images to desired images (Fig. 1), such as a rainy image to its de-rained counterpart, object edges to photos, and semantic labels to a scenes image. The proposed PAN consists of two feed-forward convolutional neural networks: the image transformation network T and the discriminative network D. Besides the generative adversarial loss widely used in GANs, we propose the perceptual adversarial loss, which undergoes an adversarial training process between the image transformation network T and the hidden layers of the discriminative network D. The hidden layers and the output of the discriminative network D are upgraded to constantly and automatically discover the discrepancy between the transformed image and the corresponding ground truth, while the image transformation network T is trained to minimize the discrepancy explored by the discriminative network D. Through integrating the generative adversarial loss and the perceptual adversarial loss, D and T can be trained alternately to solve image-to-image transformation tasks. Experiments evaluated on several image-to-image transformation tasks (e.g., image deraining and image inpainting) demonstrate the effectiveness of the proposed PAN and its advantages over many existing works.
  @cite_14: Adversarial training has been shown to produce state of the art results for generative image modeling. In this paper we propose an adversarial training approach to train semantic segmentation models. We train a convolutional semantic segmentation network along with an adversarial network that discriminates segmentation maps coming either from the ground truth or from the segmentation network. The motivation for our approach is that it can detect and correct higher-order inconsistencies between ground truth segmentation maps and the ones produced by the segmentation net. Our experiments show that our adversarial training approach leads to improved accuracy on the Stanford Background and PASCAL VOC 2012 datasets.
  @cite_33: 
  @cite_8: Convolutional neural networks (CNNs) have been applied to various automatic image segmentation tasks in medical image analysis, including brain MRI segmentation. Generative adversarial networks have recently gained popularity because of their power in generating images that are difficult to distinguish from real images.
  @cite_48: Automatic liver segmentation in 3D medical images is essential in many clinical applications, such as pathological diagnosis of hepatic diseases, surgical planning, and postoperative assessment. However, it is still a very challenging task due to the complex background, fuzzy boundary, and various appearance of liver. In this paper, we propose an automatic and efficient algorithm to segment liver from 3D CT volumes. A deep image-to-image network (DI2IN) is first deployed to generate the liver segmentation, employing a convolutional encoder-decoder architecture combined with multi-level feature concatenation and deep supervision. Then an adversarial network is utilized during training process to discriminate the output of DI2IN from ground truth, which further boosts the performance of DI2IN. The proposed method is trained on an annotated dataset of 1000 CT volumes with various different scanning protocols (e.g., contrast and non-contrast, various resolution and position) and large variations in populations (e.g., ages and pathology). Our approach outperforms the state-of-the-art solutions in terms of segmentation accuracy and computing efficiency.
  @cite_1: Semantic segmentation constitutes an integral part of medical image analyses for which breakthroughs in the field of deep learning were of high relevance. The large number of trainable parameters of deep neural networks however renders them inherently data hungry, a characteristic that heavily challenges the medical imaging community. Though interestingly, with the de facto standard training of fully convolutional networks (FCNs) for semantic segmentation being agnostic towards the structure' of the predicted label maps, valuable complementary information about the global quality of the segmentation lies idle. In order to tap into this potential, we propose utilizing an adversarial network which discriminates between expert and generated annotations in order to train FCNs for semantic segmentation. Because the adversary constitutes a learned parametrization of what makes a good segmentation at a global level, we hypothesize that the method holds particular advantages for segmentation tasks on complex structured, small datasets. This holds true in our experiments: We learn to segment aggressive prostate cancer utilizing MRI images of 152 patients and show that the proposed scheme is superior over the de facto standard in terms of the detection sensitivity and the dice-score for aggressive prostate cancer. The achieved relative gains are shown to be particularly pronounced in the small dataset limit.
  @cite_24: Recently, the convolutional neural network (CNN) has been successfully applied to the task of brain tumor segmentation. However, the effectiveness of a CNN-based method is limited by the small receptive field, and the segmentation results don’t perform well in the spatial contiguity. Therefore, many attempts have been made to strengthen the spatial contiguity of the network output. In this paper, we proposed an adversarial training approach to train the CNN network. A discriminator network is trained along with a generator network which produces the synthetic segmentation results. The discriminator network is encouraged to discriminate the synthetic labels from the ground truth labels. Adversarial adjustments provided by the discriminator network are fed back to the generator network to help reduce the differences between the synthetic labels and the ground truth labels and reinforce the spatial contiguity with high-order loss terms. The presented method is evaluated on the Brats2017 training dataset. The experiment results demonstrate that the presented method could enhance the spatial contiguity of the segmentation results and improve the segmentation accuracy.
  @cite_23: Spleen volume estimation using automated image segmentation technique may be used to detect splenomegaly (abnormally enlarged spleen) on Magnetic Resonance Imaging (MRI) scans. In recent years, Deep Convolutional Neural Networks (DCNN) segmentation methods have demonstrated advantages for abdominal organ segmentation. However, variations in both size and shape of the spleen on MRI images may result in large false positive and false negative labeling when deploying DCNN based methods. In this paper, we propose the Splenomegaly Segmentation Network (SSNet) to address spatial variations when segmenting extraordinarily large spleens. SSNet was designed based on the framework of image-to-image conditional generative adversarial networks (cGAN). Specifically, the Global Convolutional Network (GCN) was used as the generator to reduce false negatives, while the Markovian discriminator (PatchGAN) was used to alleviate false positives. A cohort of clinically acquired 3D MRI scans (both T1 weighted and T2 weighted) from patients with splenomegaly were used to train and test the networks. The experimental results demonstrated that a mean Dice coefficient of 0.9260 and a median Dice coefficient of 0.9262 using SSNet on independently tested MRI volumes of patients with splenomegaly.
  @cite_2: Organ segmentation in chest X-rays using convolutional neural networks is disclosed. One embodiment provides a method to train a convolutional segmentation network with chest X-ray images to generate pixel-level predictions of target classes. Another embodiment will also train a critic network with an input mask, wherein the input mask is one of a segmentation network mask and a ground truth annotation, and outputting a probability that the input mask is the ground truth annotation instead of the prediction by the segmentation network, and to provide the probability output by the critic network to the segmentation network to guide the segmentation network to generate masks more consistent with learned higher-order structures.
  @cite_5: We introduce scGAN, a novel extension of conditional Generative Adversarial Networks (GAN) tailored for the challenging problem of shadow detection in images. Previous methods for shadow detection focus on learning the local appearance of shadow regions, while using limited local context reasoning in the form of pairwise potentials in a Conditional Random Field. In contrast, the proposed adversarial approach is able to model higher level relationships and global scene characteristics. We train a shadow detector that corresponds to the generator of a conditional GAN, and augment its shadow accuracy by combining the typical GAN loss with a data loss term. Due to the unbalanced distribution of the shadow labels, we use weighted cross entropy. With the standard GAN architecture, properly setting the weight for the cross entropy would require training multiple GANs, a computationally expensive grid procedure. In scGAN, we introduce an additional sensitivity parameter w to the generator. The proposed approach effectively parameterizes the loss of the trained detector. The resulting shadow detector is a single network that can generate shadow maps corresponding to different sensitivity levels, obviating the need for multiple models and a costly training procedure. We evaluate our method on the large-scale SBU and UCF shadow datasets, and observe up to 17 error reduction with respect to the previous state-of-the-art method.
  @cite_20: In this work, we segment spheroids with different sizes, shapes, and illumination conditions from bright-field microscopy images. To segment the spheroids we create a novel multiscale deep adversarial network with different deep feature extraction layers at different scales. We show that linearly increasing the adversarial loss contribution results in a stable segmentation algorithm for our dataset. We qualitatively and quantitatively compare the performance of our deep adversarial network with two other networks without adversarial losses. We show that our deep adversarial network performs better than the other two networks at segmenting the spheroids from our 2D bright-field microscopy images.
summary: . Adversarial training schemes have been extensively employed in the literature to impose structural consistencies for semantic segmentation @cite_30 @cite_14 @cite_33 @cite_2 @cite_23 @cite_1 @cite_8 @cite_48 @cite_24 @cite_20 @cite_5 . @cite_14 incorporate a discriminator network trained to distinguish the real labels and network-produced predictions. Involving the segmenter in a minimax game with the discriminator motivates the network to bridge the gap between the two distributions and consequently having higher-level consistencies in predicted labels.