text: Anatomical landmark segmentation and pathology localization are important steps in automated analysis of medical images. They are particularly challenging when the anatomy or pathology is small, as in retinal images and cardiac MRI, or when the image is of low quality due to device acquisition parameters as in magnetic resonance (MR) scanners. We propose an image super-resolution method using progressive generative adversarial networks (P-GAN) that can take as input a low-resolution image and generate a high resolution image of desired scaling factor. The super resolved images can be used for more accurate detection of landmarks and pathology. Our primary contribution is in proposing a multistage model where the output image quality of one stage is progressively improved in the next stage by using a triplet loss function. The triplet loss enables stepwise image quality improvement by using the output of the previous stage as the baseline. This facilitates generation of super resolved images of high scaling factor while maintaining good image quality. Experimental results for image super-resolution show that our proposed multistage P-GAN outperforms competing methods and baseline GAN.
  @cite_14: Abstract Resolution in Magnetic Resonance (MR) is limited by diverse physical, technological and economical considerations. In conventional medical practice, resolution enhancement is usually performed with bicubic or B-spline interpolations, strongly affecting the accuracy of subsequent processing steps such as segmentation or registration. This paper presents a sparse-based super-resolution method, adapted for easily including prior knowledge, which couples up high and low frequency information so that a high-resolution version of a low-resolution brain MR image is generated. The proposed approach includes a whole-image multi-scale edge analysis and a dimensionality reduction scheme, which results in a remarkable improvement of the computational speed and accuracy, taking nearly 26 min to generate a complete 3D high-resolution reconstruction. The method was validated by comparing interpolated and reconstructed versions of 29 MR brain volumes with the original images, acquired in a 3T scanner, obtaining a reduction of 70 in the root mean squared error, an increment of 10.3 dB in the peak signal-to-noise ratio, and an agreement of 85 in the binary gray matter segmentations. The proposed method is shown to outperform a recent state-of-the-art algorithm, suggesting a substantial impact in voxel-based morphometry studies.
  @cite_1: We propose an image super resolution (ISR) method using generative adversarial networks (GANs) that takes a low resolution input fundus image and generates a high resolution super resolved (SR) image upto scaling factor of 16. This facilitates more accurate automated image analysis, especially for small or blurred landmarks and pathologies. Local saliency maps, which define each pixel’s importance, are used to define a novel saliency loss in the GAN cost function. Experimental results show the resulting SR images have perceptual quality very close to the original images and perform better than competing methods that do not weigh pixels according to their importance. When used for retinal vasculature segmentation, our SR images result in accuracy levels close to those obtained when using the original images.
  @cite_24: 
  @cite_19: 3D cardiac MR imaging enables accurate analysis of cardiac morphology and physiology. However, due to the requirements for long acquisition and breath-hold, the clinical routine is still dominated by multi-slice 2D imaging, which hamper the visualization of anatomy and quantitative measurements as relatively thick slices are acquired. As a solution, we propose a novel image super-resolution (SR) approach that is based on a residual convolutional neural network (CNN) model. It reconstructs high resolution 3D volumes from 2D image stacks for more accurate image analysis. The proposed model allows the use of multiple input data acquired from different viewing planes for improved performance. Experimental results on 1233 cardiac short and long-axis MR image stacks show that the CNN model outperforms state-of-the-art SR methods in terms of image quality while being computationally efficient. Also, we show that image segmentation and motion tracking benefits more from SR-CNN when it is used as an initial upscaling method than conventional interpolation methods for the subsequent analysis.
  @cite_2: It is faster and therefore cheaper to acquire magnetic resonance images (MRI) with higher in-plane resolution than through-plane resolution. The low resolution of such acquisitions can be increased using post-processing techniques referred to as super-resolution (SR) algorithms. SR is known to be an ill-posed problem. Most state-of-the-art SR algorithms rely on the presence of external training data to learn a transform that converts low resolution input to a higher resolution output. In this paper an SR approach is presented that is not dependent on any external training data and is only reliant on the acquired image. Patches extracted from the acquired image are used to estimate a set of new images, where each image has increased resolution along a particular direction. The final SR image is estimated by combining images in this set via the technique of Fourier Burst Accumulation. Our approach was validated on simulated low resolution MRI images, and showed significant improvement in image quality and segmentation accuracy when compared to competing SR methods. SR of FLuid Attenuated Inversion Recovery (FLAIR) images with lesions is also demonstrated.
  @cite_15: Image quality transfer (IQT) aims to enhance clinical images of relatively low quality by learning and propagating high-quality structural information from expensive or rare data sets. However, the original framework gives no indication of confidence in its output, which is a significant barrier to adoption in clinical practice and downstream processing. In this article, we present a general Bayesian extension of IQT which enables efficient and accurate quantification of uncertainty, providing users with an essential prediction of the accuracy of enhanced images. We demonstrate the efficacy of the uncertainty quantification through super-resolution of diffusion tensor images of healthy and pathological brains. In addition, the new method displays improved performance over the original IQT and standard interpolation techniques in both reconstruction accuracy and robustness to anomalies in input images.
  @cite_25: 
  @cite_17: Lossy compression introduces complex compression artifacts, particularly the blocking artifacts, ringing effects and blurring. Existing algorithms either focus on removing blocking artifacts and produce blurred output, or restores sharpened images that are accompanied with ringing effects. Inspired by the deep convolutional networks (DCN) on super-resolution, we formulate a compact and efficient network for seamless attenuation of different compression artifacts. We also demonstrate that a deeper model can be effectively trained with the features learned in a shallow network. Following a similar "easy to hard" idea, we systematically investigate several practical transfer settings and show the effectiveness of transfer learning in low level vision problems. Our method shows superior performance than the state-of-the-arts both on the benchmark datasets and the real-world use cases (i.e. Twitter).
summary: Parametric generative models, such as coupled-dictionary learning based approaches, have been proposed to upscale MR brain @cite_14 and cardiac @cite_24 images. These methods benefit from sparsity constraint to express the link between LR and HR. Similarly, random forest based non-linear regressors have been proposed to predict HR patches from LR data and have been successfully applied on diffusion tensor images @cite_15 . Recently, convolutional neural network (CNN) models @cite_17 have been put forward to replace the inference step as they have enough capacity to perform complex nonlinear regression tasks. Even by using a shallow network composed of a few layers, @cite_17 achieve superior results over other state-of-the art SR methods. Recent works have proposed image SR methods based on training data free approach using Fourier burst accumulation @cite_2 , CNNs @cite_19 and generative adversarial networks (GANs) @cite_25 @cite_1 .