Knightley medvirkede i dramaet ''[[Last Night (film fra 2010)|Last Night]]'' overfor [[Eva Mendes]], [[Sam Worthington]] og [[Guillaume Canet]]; filmen blev instrueret af [[Massy Tadjedin]].<ref>{{cite web |title=Keira Knightley to look back at 'Last Night' |url=http://www.thehollywoodnews.com/artman2/publish/movie_news/Keira-Knightley-to-look-back-at-Last-Night-12180908.php |publisher=Thehollywoodnews.com |date=18. september 2008 |access-date=20. oktober 2008 |first=Thomas |last=Sampson |archive-url=https://web.archive.org/web/20090606172158/http://www.thehollywoodnews.com/artman2/publish/movie_news/Keira-Knightley-to-look-back-at-Last-Night-12180908.php |archive-date= 6. juni 2009 |url-status=live }}</ref><ref>{{cite web |url=http://afp.google.com/article/ALeqM5iJwNVdMw3ywlKhuI8T2r1MDY0MxQ |title=AFP: Knightley to star in new movie 'Last Night&#39 |publisher=Google |date=18. september 2008 |access-date=20. oktober 2008 |archive-url=https://web.archive.org/web/20080922165738/http://afp.google.com/article/ALeqM5iJwNVdMw3ywlKhuI8T2r1MDY0MxQ |archive-date=22. september 2008 |url-status=dead }}</ref> I april 2009 påbegyndte Knightley arbejdet med filmfortolkningen af samme navn efter den dystopiske roman "Never Let Me Go" af [[Kazuo Ishiguro]] med [[Andrew Garfield]] og [[Carey Mulligan]]. Optagelserne fandt sted i [[Norfolk]] og [[Clevedon]] i Somerset.<ref>{{Cite news|title=Keira Knightley set for 'Never' |url=http://www.variety.com/article/VR1118000704.html?categoryid=13&cs=1&nid=2563 |work=Variety |date= 1. marts 2009|access-date=24. april 2009 | first1=Ali | last1=Jaafar | first2=Tatiana | last2=Siegel}}</ref><ref>{{cite web |title=Keira Knightley is all smiles on set in Clevedon |url=http://www.thisissomerset.co.uk/clevedon/news/Keira-Knightley-smiles-set-Clevedon/article-933789-detail/article.html |publisher=Thisissomerset.co.uk |date=16. april 2009 |access-date=24. april 2009 |archive-date=15. maj 2009 |archive-url=https://web.archive.org/web/20090515014120/http://www.thisissomerset.co.uk/clevedon/news/Keira-Knightley-smiles-set-Clevedon/article-933789-detail/article.html |url-status=dead }}</ref>
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