Fra 2013 blev Dempsey ansigtet for Silhouette, et østrigsk brillefirma.<ref>D'Allesandro, Stefania. [http://www.people.com/people/mobile/gallery/0,,20678682_21289975,00.html "Good Eye"] {{webarchive|url=https://web.archive.org/web/20140102191037/http://www.people.com/people/mobile/gallery/0,,20678682_21289975,00.html |date=2. januar 2014 }}, ''[[People (magazine)|People]]'', March 4, 2013; retrieved May 15, 2013.</ref> Fra januar 2017 optrådte Dempsey for [[Vodafone Italy]] og han medvirker i nogle enkelte italienske reklamer i samme omgang.<ref>[http://www.vanityfair.it/lifestyle/hi-tech/17/01/03/patrick-dempsey-spot-vodafone-italia "Vodafone Italia"], ''[[Vanity Fair (magazine)|Vanity Fair]]'', March 7, 2017; retrieved March 7, 2017.</ref> I 2018 lancerede Bleusalt, et Malibu-grundlagt modebrand, en kollektion designet af skuespilleren.<ref>{{cite news |last1=Perez |first1=Lexy |title=Patrick Dempsey Launches Clothing Collection with Bleusalt |url=https://www.hollywoodreporter.com/news/patrick-dempsey-launches-clothing-collection-bleusalt-1122483 |access-date=3. april 2019 |agency=The Hollywood Reporter |publisher=Prometheus Global Media LLC |date=21. juni 2018}}</ref><ref>{{cite news |last1=Medina |first1=Marcy |title=Patrick Dempsey Designs Clothing Capsule With Lyndie Benson's Bleusalt |url=https://wwd.com/fashion-news/fashion-scoops/patrick-dempsey-designs-clothing-capsule-with-lyndie-benson-bleusalt-1202719970/ |access-date=3. april 2019 |agency=Women's Wear Daily |publisher=Penske Media Corporation |date=19. juni 2018}}</ref>
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