David er mest kendt for Dolce & Gabbanas parfume kampagne ”Light Blue” med Marija Vuyovic (billeder og video af fotograf Mario Testino). Kampagnen havde 11 millioner online hits og det resulterede i en 15 meter høj billboard af Gandy på [[Times Square]].<ref name="Vogue-DavidGandyBio">{{cite journal| url=http://www.vogue.co.uk/person/david-gandy| journal=Vogue UK| title=David Gandy bio| access-date=5. december 2012| archive-date= 6. april 2019| archive-url=https://web.archive.org/web/20190406213147/https://www.vogue.co.uk/person/david-gandy|url-status=live}}</ref> I 2008 blev han fotograferet af Mariano Vivanco til Dolce & Gabbana kalenderen.<ref>{{cite news| url=http://www.thetimes.co.uk/tto/life/fashion/mensstyle/article2481756.ece| newspaper=[[The Times]]| title=A Week with Male Model David Gandy| access-date=5. december 2012| archive-date= 4. marts 2016| archive-url=https://web.archive.org/web/20160304231204/http://www.thetimes.co.uk/tto/life/fashion/mensstyle/article2481756.ece|url-status=live}}</ref> Gandy vendte tilbage som ansigtet for den anden ”Light Blue” kampagne i 2010, denne gang sammen med Anna Jagodzinska.<ref>{{cite web| url=http://models.com/work/dolce-and-gabbana-dolce--gabbana-light-blue-fragrance-contract-2010-fw-10-1| publisher=Models.com| title=Dolce & Gabbana Light Blue Fragrance Contract 2010| access-date=5. december 2012| archive-date=27. november 2015| archive-url=https://web.archive.org/web/20151127221135/http://models.com/work/dolce-and-gabbana-dolce--gabbana-light-blue-fragrance-contract-2010-fw-10-1|url-status=live}}</ref> Han har også lavet en kort film for W Hotels med danske Helena Christensen kaldet ”Away We Stay”.<ref>{{cite news| url=http://www.telegraph.co.uk/news/newstopics/celebritynews/7936935/David-Gandy-to-make-his-film-debut.html| newspaper=[[The Daily Telegraph]]| title=David Gandy to make his film debut| access-date=5. december 2012| archive-date=30. januar 2011| archive-url=https://web.archive.org/web/20110130150707/http://www.telegraph.co.uk/news/newstopics/celebritynews/7936935/David-Gandy-to-make-his-film-debut.html|url-status=live}}</ref>
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