Det er blevet hævdet at kortet er usædvanligt nøjagtigt, men dette er efter videnskabelig undersøgelse blevet afvist.
<ref>[http://www.intersurf.com/~chalcedony/FOG9.html Re: Piri Reis Map] {{Webarchive|url=https://web.archive.org/web/20030621110651/http://www.intersurf.com/~chalcedony/FOG9.html |date=21. juni 2003 }} Citat: "...William Miller wrote:...The examinations that I have made of it show all sorts of errors that certainly falsify any claim of unusual accuracy for this map..."</ref>
<ref name="mercatormag"/>
<ref>Webarchive backup: [https://web.archive.org/web/20030416161823/http://www.survive2012.com/pirireismap.html Webarchive backup: Survive 2012: Piri Reis] Citat: "...The projections originate from a point at the intersection of the meridian of Alexandria (30°E) and the Tropic of Cancer....Longitudes were not able to be accurately calculated until the 1770's when John Harrison invented his Chronometer No.4. However, the Piri Reis map has correct and accurate relative longitudes...Maps by [[Gerardus Mercator|Mercator]], [[Oronteus Fineaus]] and [[Phillipe Buache]] also show the pre-glacial Antarctica – before it was discovered ..."</ref>
<ref>Webarchive backup: [https://web.archive.org/web/20001005182410/http://www.geocities.com/Area51/Cavern/9956/piri3.html Commander Ohlmeyer's letter] Citat: "...The geographical detail shown in the lower part of the map agrees very remarkably with the results of the seismic profile made across the top of the ice-cap by the Swedish-British Antarctic Expedition of [[1949]]. This indicates the coastline had been mapped before it was covered by the ice-cap...."</ref>
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