'''Sir Gregory Paul Winter''' <small>[[Order of the British Empire|CBE]] [[Fellow of the Royal Society|FRS]] [[Fellow of the Academy of Medical Sciences|FMedSci]]</small> (født [[14. april]] [[1951]]) er en britisk [[biokemiker]], der er bedst kendt for sin forskning i terapeutisk brug af [[monoklonale antistoffer]]. Han opfandt teknikker til både [[humaniseret anistof|humaniseret]] (1986) og senere fuldt humaniseret [[phage display]], antistoffer til terapeutisk brug.<ref>{{Cite journal| doi = 10.1038/348552a0| pmid = 2247164| year = 1990| last1 = McCafferty | first1 = J.| author-link1 = John McCafferty| last2 = Griffiths | first2 = A.| last3 = Winter | first3 = G.| author-link3 = Greg Winter| last4 = Chiswell | first4 = D.| author-link4 = David Chiswell| title = Phage antibodies: filamentous phage displaying antibody variable domains| volume = 348| issue = 6301| pages = 552–554| journal = Nature |bibcode = 1990Natur.348..552M }}</ref><ref name=bicycle>The [http://www.bicycletherapeutics.com/about/scientific-founders Scientific Founders] {{webarchive|url=https://web.archive.org/web/20110913014724/http://www.bicycletherapeutics.com/about/scientific-founders |date=13. september 2011 }} of Bicycle Therapeutics Ltd. – Christian Heinis and Sir Greg Winter, FRS.</ref><ref>[http://www.trin.cam.ac.uk/index.php?pageid=176&conid=87 www.trin.cam.ac.uk] {{webarchive|url=https://web.archive.org/web/20120306054554/http://www.trin.cam.ac.uk/index.php?pageid=176&conid=87 |date=6. marts 2012 }}</ref><ref>{{Cite journal
 | pmid = 8045255
| year = 1994
| author1 = Griffiths
| first1 = A. D.
| title = Isolation of high affinity human antibodies directly from large synthetic repertoires
| journal = The EMBO Journal
| volume = 13
| issue = 14
| pages = 3245–60
| last2 = Williams
| first2 = S. C.
| last3 = Hartley
| first3 = O
| last4 = Tomlinson
| first4 = I. M.
| last5 = Waterhouse
| first5 = P
| last6 = Crosby
| first6 = W. L.
| last7 = Kontermann
| first7 = R. E.
| last8 = Jones
| first8 = P. T.
| last9 = Low
| first9 = N. M.
| last10 = Allison
| first10 = T. J.
| pmc = 395221
}}</ref><ref>{{Cite journal
 | pmid = 1908075
| year = 1991
| author1 = Hoogenboom
| first1 = H. R.
| title = Multi-subunit proteins on the surface of filamentous phage: Methodologies for displaying antibody (Fab) heavy and light chains
| journal = Nucleic Acids Research
| volume = 19
| issue = 15
| pages = 4133–7
| last2 = Griffiths
| first2 = A. D.
| last3 = Johnson
| first3 = K. S.
| last4 = Chiswell
| first4 = D. J.
| last5 = Hudson
| first5 = P
| last6 = Winter
| first6 = G
| pmc = 328552
 | doi=10.1093/nar/19.15.4133
}}</ref> Tidligere blev antistof udvundet fra [[mus]], hvilket gjorde det vanskeligt at bruge terapeutisk, da det menneskelige [[immunsystem]] angreb antistoffet fra mus.<ref>{{Cite journal| author = Anon | doi = 10.1038/nbt.1815| pmid = 21390009| title = The inventor of humanized monoclonal antibodies and cofounder of Cambridge Antibody Technology, Greg Winter, muses on the future of antibody therapeutics and UK life science innovation| url = https://archive.org/details/sim_nature-biotechnology_2011-03_29_3/page/190 | journal = [[Nature Biotechnology]]| volume = 29| issue = 3| pages = 190| year = 2011}}</ref><ref>{{Cite journal | doi = 10.1038/292072a0| pmid = 7278968| title = Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype| journal = Nature| volume = 292| issue = 5818| pages = 72–5| year = 1981| last1 = Winter | first1 = G. | author-link1 = Greg Winter| last2 = Fields | first2 = S. | author-link2 = Stanley Fields (biologist)| last3 = Brownlee | first3 = G. G. | author-link3 = George Brownlee| bibcode = 1981Natur.292...72W}} {{closed access}}</ref><ref>{{Cite journal | doi = 10.1038/290213a0| pmid = 7010182| title = Structure of the neuraminidase gene in human influenza virus A/PR/8/34| journal = [[Nature (journal)|Nature]]| volume = 290| issue = 5803| pages = 213–7| year = 1981| last1 = Fields | first1 = S. | author-link1 = Stanley Fields (biologist)| last2 = Winter | first2 = G. | author-link2 = Greg Winter| last3 = Brownlee | first3 = G. G. | author-link3 = George Brownlee| bibcode = 1981Natur.290..213F}} {{closed access}}</ref><ref>{{Cite journal | doi = 10.1038/332323a0| pmid = 3127726| title = Reshaping human antibodies for therapy| journal = Nature| volume = 332| issue = 6162| pages = 323–7| year = 1988| last1 = Riechmann | first1 = L. | last2 = Clark | first2 = M. | last3 = Waldmann | first3 = H. | last4 = Winter | first4 = G. | bibcode = 1988Natur.332..323R}} {{closed access}}</ref><ref>{{Cite journal | doi = 10.1016/0022-2836(91)90498-U| pmid = 1748994| title = By-passing immunization| journal = [[Journal of Molecular Biology]]| volume = 222| issue = 3| pages = 581–97| year = 1991| last1 = Marks | first1 = J. D. | last2 = Hoogenboom | first2 = H. R. | last3 = Bonnert | first3 = T. P. | last4 = McCafferty | first4 = J. | last5 = Griffiths | first5 = A. D. | last6 = Winter | first6 = G. }} {{closed access}}</ref> I 2018 modtog han [[nobelprisen i kemi]] sammen med [[George Smith (kemiker)|George Smith]] og [[Frances Arnold]].<ref name=nobel-1>{{cite web|url=https://www.chemistryworld.com/news/live-blog-2018-chemistry-nobel-prize/3009569.article |title=Live blog: direction evolution takes chemistry Nobel prize|access-date=3. oktober 2018}}</ref>
Levende_personer Kemi