Den 4. december 2021 vandt Pécresse det republikanske kandidatur i den sidste afstemningsrunde med 61 % af stemmerne afgivet af partimedlemmer, mod 39 % til rivalen Éric Ciotti.<ref>{{Cite web|last=News|first=Bloomberg|date=2021-12-04|title=France’s Republicans Pick Pecresse as Presidential Candidate - BNN Bloomberg|url=https://www.bnnbloomberg.ca/france-s-republicans-pick-pecresse-as-presidential-candidate-1.1691075|access-date=2021-12-04|website=BNN}}</ref><ref>{{Cite web|date=2021-12-04|title=French election 2022: Valérie Pécresse wins conservative primary|url=https://www.euronews.com/2021/12/04/french-presidential-election-2022-valerie-pecresse-wins-conservative-primary|access-date=2021-12-04|website=euronews|language=en}}</ref>
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