I juli 2021 annoncerede Pécresse sit kandidatur til den republikanske nominering af partiets præsidentkandidat til [[præsidentvalget i Frankrig 2022]].<ref>{{Cite web | date=2021-07-22 | title=Head of Paris region announces presidential bid | url=https://www.politico.eu/article/head-of-paris-region-valerie-pecresse-announces-presidential-run/|access-date=2021-11-19|website=POLITICO|language=en-US}}</ref><ref>{{Cite web | date=2021-09-26 | title=Conservative Les Républicains forgo primary to choose candidate at party convention|url=https://www.france24.com/en/europe/20210926-french-conservatives-ditch-primaries-for-party-convention-ahead-of-presidential-poll|access-date=2021-11-19|website=France 24|language=en}}</ref>
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