Blaydes mødte Francis Ngannou i en rematch den 24. november 2018 i hovedkampen på UFC Fight Night 141 <ref name="BeijingME">{{Cite web|url=http://www.punditarena.com/mma/ccunningham/curtis-blaydesfrancis-ngannou-rematch-set-ufc-beijing/|title=Curtis Blaydes/Francis Ngannou rematch set for UFC Beijing|publisher=punditarena.com|last=Cillian Cunniingham|date=2016-08-16|access-date=2016-08-16|archive-date=29. marts 2019|archive-url=https://web.archive.org/web/20190329103701/https://punditarena.com/mma/ccunningham/curtis-blaydesfrancis-ngannou-rematch-set-ufc-beijing/|url-status=dead}}</ref> Han tabte kampen via TKO tidligt i første runde. <ref>{{Cite web|url=http://www.sherdog.com/news/news/Francis-Ngannou-Returns-to-Form-Blasts-Curtis-Blaydes-in-UFC-Fight-Night-141-Headliner-145979|title=Francis Ngannou Returns to Form, Blasts Curtis Blaydes in UFC Fight Night 141 Headliner|last=Sherdog.com|website=Sherdog|access-date=2018-11-24}}</ref>
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