{{DISPLAYTITLE:''N''-Methyl-<small>D</small>-aspartatsyre}}
{{Infoboks kemi
| Watchedfields = changed
| verifiedrevid = 312363528
| Name = ''N''-Methyl-<small>D</small>-aspartic acid
| ImageFile = NMDA.svg
| ImageFile_Ref = {{chemboximage|correct|??}}
| ImageSize = 160
| ImageName = Stereo, skeletal formula of N-methyl-D-aspartic acid
| ImageFile1 = NMDA2.png
| ImageFile1_Ref = {{chemboximage|correct|??}}
| ImageSize1 = 160
| ImageName1 = Ball and stick model of N-methyl-D-aspartic acid
| ImageFile2 = NMDA spacefill.png
| ImageFile2_Ref = {{chemboximage|correct|??}}
| ImageSize2 = 160
| ImageName2 = Spacefill model of N-methyl-D-aspartic acid
| IUPACName = (2''R'')-2-(Methylamino)butanedioic acid<ref>{{cite web|title=N-Methylaspartate - Compound Summary|url=http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=22880&loc=ec_rcs|work=PubChem Compound|publisher=National Center for Biotechnology Information|accessdate=9. januar 2012|location=USA|date=24. juni 2005|at=Identification}}</ref>
| OtherNames = ''N''-Methylaspartate; ''N''-Methyl-<small>D</small>-aspartate; NMDA
|Section1={{Chembox Identifiers
| IUPHAR_ligand = 4268
| CASNo = 6384-92-5
| CASNo_Ref = {{cascite|correct|??}}
| PubChem = 22880
| ChemSpiderID = 21436
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| KEGG = C12269
| KEGG_Ref = {{keggcite|correct|kegg}}
| MeSHName = N-Methylaspartate
| ChEBI = 31882
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 291278
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| RTECS = CI9457000
| Beilstein = 1724431
| SMILES = CN[C@H](Cc(:[o]):[o])c(:[o]):[o]
| SMILES1 = CN[C@H](CC(O)=O)C(O)=O
| StdInChI = 1 S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
| StdInChIKey = HOKKHZGPKSLGJE-GSVOUGTGSA-N
  }}
|Section2={{Chembox Properties
| C=5 | H=9 | N=1 | O=4
| Appearance = White, opaque crystals
| Odor = Odorless
| MeltingPtC = 189 to 190
| LogP = 1.39
| pKa = 2.206
| pKb = 11.791
 }}
|Section3={{Chembox Hazards
| SPhrases = {{S22}}, {{S24/25}}
| LD50 = 137 mg kg<sup>−1</sup> (intraperitoneal, mouse)
 }}
|Section4={{Chembox Related
| OtherFunction_label = amino acid derivatives
| OtherFunction = {{unbulleted list|[[Sarcosine]]|[[Dimethylglycine]]|[[beta-Methylamino-L-alanine|''beta''-Methylamine-<small>L</small>-alanine]]}}
| OtherCompounds = [[Dimethylacetamide]]
 }}
}}
'''''N''-Methyl-<small>D</small>-aspartatsyre''' eller '''''N''-Methyl-<small>D</small>-aspartat''' ('''NMDA''') er et [[aminosyre]]derivat der agerer en specifik [[receptoragonist|agonist]] på [[NMDA-receptor]]en, og gengiver [[glutamat]]s handlingsmønster, den [[neurotransmitter]] der normalt agerer ved receptoren. I modsætning til glutamat, binder regulerer NMDA sig kun til NMDA, og har ingen effekt på andre glutamatreceptorer (såsom dem for [[AMPA]] og [[kainat]]). NMDA-receptorer er specielt vigtigt når de bliver overaktive ved [[Frigørelse fra stoffer|frigørelse]] fra [[etanol|alkohol]], da det skaber symptomer såsom [[Psykomotorisk agitation|agitation]] og, nogle gange, epileptiskagtige [[anfald]].
== Noter ==
{{reflist}}
Kemi Videnskab Naturvidenskab