Et [[helgenomsassociationsstudie]] (''Genome-wide association study'' eller ''GWAS'') af mere end 100.000 personer fandt at varianter af genet ''KLB'', der koder [[transmembranprotein]]et β-[[Klotho (enzym)|Klotho]], var kraftigt associeret med alkoholindtag. Proteinet β-Klotho er et essentielt stof i [[membranreceptor]]er for [[hormon]]er involveret i modulering af appetit for [[monosakkarider]] og alkohol.<ref>{{cite journal|last1=Schumann|first1=G |s2cid=4060021 |display-authors=et al|title=KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference|journal=PNAS USA|date=2016|volume=113|issue=50|pages=14372–77|doi=10.1073/pnas.1611243113|pmid=27911795|pmc=5167198}}</ref> Et GWAS forskelle i alkoholindtag og alkoholafhængighed, omend de to er forbundet i en vis grad.<ref name=":1">{{Cite journal|last1=Walters|first1=Raymond K.|last2=Polimanti|first2=Renato|last3=Johnson|first3=Emma C.|last4=McClintick|first4=Jeanette N.|last5=Adams|first5=Mark J.|last6=Adkins|first6=Amy E.|last7=Aliev|first7=Fazil|last8=Bacanu|first8=Silviu-Alin|last9=Batzler|first9=Anthony|last10=Bertelsen|first10=Sarah|last11=Biernacka|first11=Joanna M.|date=2018|title=Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders|journal=Nature Neuroscience|volume=21|issue=12|pages=1656–1669|doi=10.1038/s41593-018-0275-1|issn=1097-6256|pmc=6430207|pmid=30482948}}</ref>
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