{| class="wikitable" style="margin-left:1em; text-align:center;"
! style="width:60px;"|Rang.<ref name="wta"/>
! Spiller
! Resultat
|-
| 10
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|NED|3:2}} [[Kiki Bertens]]
| style="text-align:left; padding-left:8px; padding-right:20px;"|[[Akillessene]]skade<ref>[https://tennisuptodate.com/wta/kiki-bertens-withdraws-from-australian-open Tennis up-to-date - ''Kiki Bertens withdraws from Australian Open'' (6. januar 2021)] {{en sprog}}</ref>
|-
| 16
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Madison Keys]]
| style="text-align:left; padding-left:8px; padding-right:20px;"|Positiv [[COVID-19]]-test<ref>[https://tennishead.net/australian-open-loses-another-big-name-to-coronavirus-as-madison-keys-tests-positive/ Tennishead - ''Australian Open loses another big name to coronavirus as Madison Keys tests positive'' (15. januar 2021)] {{en sprog}}</ref>
|-
| 29
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|UKR|3:2}} [[Dajana Jastremska]]
| style="text-align:left; padding-left:8px; padding-right:20px;"|Midlertidigt suspenderet af [[International Tennis Federation|ITF]] pga. positiv [[doping]]test<ref>[https://antidoping.itftennis.com/news/317960.aspx ITF - ''Provisional suspension imposed on Dayana Yastremska '' (7. januar 2021)] {{Webarchive|url=https://web.archive.org/web/20210108041423/https://antidoping.itftennis.com/news/317960.aspx |date= 8. januar 2021 }} {{en sprog}}</ref>
|-
| 31
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Amanda Anisimova]]
| style="text-align:left; padding-left:8px; padding-right:20px;"|Positiv [[COVID-19]]-test<ref>[https://au.sports.yahoo.com/amanda-anisimovas-devastating-news-ahead-of-australian-open-043316590.html Yahoo Sport Australia - ''Amanda Anisimova's devastating news ahead of Australian Open'' (9. januar 2021)] {{en sprog}}</ref>
|}
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