Morales kommer fra en fattig familie<ref name="WSJ">{{Cite news |url=http://www.wsj.com/articles/tv-comedian-former-businessman-lead-guatemalan-election-1441597400 |title=Comedian Jimmy Morales Leads Guatemalan Election |author=Juan Montes |newspaper=The Wall Street Journal |date=7. september 2015}}</ref> og er [[Evangelisk|evangelisk kristen]].<ref name="Elpais">{{Cite news |author=José Elías |title=Jimmy Morales, el candidato sorpresa |newspaper=El País |date=7. september 2015 |url=http://internacional.elpais.com/internacional/2015/09/07/actualidad/1441605730_868386.html}}</ref> Han er uddannet indenfor [[Bachelor of Business Administration|Business Administration]] fra [[Universidad de San Carlos de Guatemala]] og [[teologi]].<ref name="Elpais"/> Han har endvidere fungeret som tegnefilmsdubber.{{kilde mangler|dato=juni 2017}}
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