Machida mødte [[Vitor Belfort]] den 12. maj, 2018 på [[UFC 224]].<ref>{{cite news|url=http://www.espn.com/mma/story/_/id/22481883/brazilians-vitor-belfort-lyoto-machida-meet-ufc-224-rio|title=Vitor Belfort-Lyoto Machida match slated for UFC 224 in Rio|website=espn.com|author=Brett Okamoto|date=2018-02-17|access-date=2018-02-17}}</ref> Han vandt kampen via knockout i 2. omgang.<ref>{{Cite news|url=https://mmajunkie.com/2018/05/ufc-224-results-lyoto-machida-front-kick-flattens-retiring-vitor-belfort-in-second|title=UFC 224 results: Lyoto Machida front kick flattens retiring Vitor Belfort in second|date=2018-05-13|work=MMAjunkie|access-date=2018-05-13|language=en-US}}</ref> Denne sejr tildelte ham [[Liste over UFC bonus award-modtagere|Performance of the Night]]-prisen.<ref name=autogeneret1>{{Cite news|url=https://mmajunkie.com/2018/05/ufc-224-bonuses-lyoto-machidas-sick-head-kick-ko-of-belfort-gets-50000|title=UFC 224 bonuses: Lyoto Machida's sick head-kick KO of Belfort gets $50,000|date=2018-05-13|work=MMAjunkie|access-date=2018-05-13|language=en-US}}</ref>
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