Manuwa mødte [[Thiago Santos]] den 8. december 2018 på UFC 231. <ref>{{Kilde nyheder|url=https://mmajunkie.com/2018/10/jimi-manuwa-vs-thiago-marreta-santos-eryk-anders-vs-elias-theodorou-added-to-ufc-231|title=Jimi Manuwa vs. Thiago 'Marreta' Santos, Eryk Anders vs. Elias Theodorou added to UFC 231|date=2018-10-02|work=MMAjunkie|access-date=2018-10-02|language=en-US}}</ref> Han tabte kampen via knockout i 2. omgang. <ref>{{Cite web|url=https://www.mmafighting.com/2018/12/8/18132556/ufc-231-results-thiago-santos-knocks-out-jimi-manuwa-in-second-round|title=UFC 231 results: Thiago Santos knocks out Jimi Manuwa in second round|last=Doyle|first=Dave|date=2018-12-08|website=MMA Fighting|access-date=2018-12-09}}</ref>
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