{| class="wikitable" style="margin-left:1em; text-align:center;"
! style="width:70px;"|Seedning
! style="width:60px;"|Rang.<ref>Sum af de to spilleres rangeringer pr. [[23. august]] [[2021]].</ref>
! Spiller
! Resultat
|-
| '''1'''
| 24
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Nicole Melichar-Martinez]]<br/>{{flagikon|CRO|3:2}} [[Ivan Dodig]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Anden runde
|-
| '''2'''
| 25
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Desirae Krawczyk]]<br/>{{flagikon|GBR|3:2}} [[Joe Salisbury]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|'''Mestre'''
|-
| '''3'''
| 33
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CHI|3:2}} [[Alexa Guarachi]]<br/>{{flagikon|GBR|3:2}} [[Neal Skupski]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Kvartfinalister
|-
| '''4'''
| 37
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|BRA|3:2}} [[Luisa Stefani]]<br/>{{flagikon|BRA|3:2}} [[Marcelo Melo]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Første runde
|-
| '''5'''
| 37
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Bethanie Mattek-Sands]]<br/>{{flagikon|GBR|3:2}} [[Jamie Murray]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Første runde
|-
| '''6'''
| 39
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|JPN|3:2}} [[Ena Shibahara]]<br/>{{flagikon|JPN|3:2}} [[Ben McLachlan]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Anden runde
|-
| '''7'''
| 41
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|TPE|3:2}} [[Chan Hao-Ching]]<br/>{{flagikon|NZL|3:2}} [[Michael Venus]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Første runde
|-
| '''8'''
| 45
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|NED|3:2}} [[Demi Schuurs]]<br/>{{flagikon|BEL|3:2}} [[Sander Gillé]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Kvartfinalister
|}
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