== TV ==
* ''The X-Files'' (1993-2002 og 2015) "Dana Scully"
* ''Future Fantastic'' (1996) Narrator
* ''Hollywood Squares'' (1996-2002) Herself
* ''The Simpsons'' (1997) Agent Dana Scully
* ''Frasier (1999)'' Jenny (voice)
* ''Bleak House (2005)'' Lady Dedlock
* ''Any Human Heart (2010)'' Duchess of Windsor
* ''Great Expectations (2011)'' Miss Havisham
* ''The Crimson Petal and the White'' (2011) Mrs. Castaway
* '' Moby Dick'' (2011) Elizabeth
* ''Hannibal'' (2013-2015) "Dr. Bedelia Du Maurier"
* ''Crisis''(2014) "Meg Fitch"
* ''[[The Fall (tv-serie)|The Fall]]'' (2013-2016) "Stella Gibson"
* ''Topgear'' (2015)
* ''War and Peace'' (2016) Anna Pavlovna Scherer
*''The Crown'' (2020)		Margaret Thatcher  (en rolle hun fik en [[Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Drama Series]] i 2021)
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