Ved [[tobaksrygning]] og anden nikotinbrug virker stoffet stimulerende på hjernens præstationsevne. Nikotin øger således nikotin-brugerens opmærksomhed, præcision, hastighed, motorik og hukommelse<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151730/pdf/nihms312569.pdf Meta-analysis of the acute effects of nicotine and smoking on human performance]. Psychopharmacology (Berl), 2010</ref> samt evnen til indlæring<ref>[http://www.uu.se/en/news/news-document/?id=1783&typ=pm&area=2&lang=en Discovery of gatekeeper nerve cells explains the effect of nicotine on learning and memory]. Uppsala Universitet, 2012</ref>. Nikotin er stærkt [[afhængighed]]sskabende.<ref name="pmid23494236">{{cite journal |vauthors=Perkins KA, Karelitz JL |title=Reinforcement enhancing effects of nicotine via smoking |journal=[[Psychopharmacology]] |volume=228 |issue=3 |pages=479–86 |date=august 2013 |pmid=23494236 |pmc=3707934 |doi=10.1007/s00213-013-3054-4 |url= |issn=}}</ref><ref name=Grana2014>{{cite journal | vauthors = Grana R, Benowitz N, Glantz SA | title = E-cigarettes: a scientific review | journal = Circulation | volume = 129 | issue = 19 | pages = 1972–86 | date = maj 2014 | pmid = 24821826 | pmc = 4018182 | doi = 10.1161/circulationaha.114.007667 }}</ref><ref name="Siqueira2016">{{cite journal | vauthors = Siqueira LM | title = Nicotine and Tobacco as Substances of Abuse in Children and Adolescents | journal = Pediatrics | volume = 139 | issue = 1 | pages = e20163436 | date = januar 2017 | pmid = 27994114 | doi = 10.1542/peds.2016-3436 | doi-access = free }}</ref> Nikotin abstinenssymptomer omfatter nedtrykthed, stress, angst, irritabilitet, koncentrationsbesvær, og søvnforstyrrelser.<ref>D'Souza MS, Markou A (July 2011). "Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments". ''Addiction Science & Clinical Practice''. '''6''' (1): 4–16. PMC 3188825. <nowiki>PMID 22003417</nowiki>. </ref>
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