Som underskriver af [[Giveløftet|Giving Pledge]]<ref>{{Cite web|last=Gren|first=Christy|date=29. maj 2019|title=MacKenzie Bezos Signs The Giving Pledge and Pledges to give Half Her Fortune|url=https://www.industryleadersmagazine.com/mackenzie-bezos-signs-the-giving-pledge-and-pledges-to-give-half-her-35-billion-fortune/|url-status=live|archive-url=https://web.archive.org/web/20190713180125/https://www.industryleadersmagazine.com/mackenzie-bezos-signs-the-giving-pledge-and-pledges-to-give-half-her-35-billion-fortune/|archive-date=13. juli 2019|access-date=13. juli 2019|website=Industry Leaders Magazine}}</ref> er Scott forpligtet til at give mindst halvdelen af sin rigdom til velgørenhed, og derfor donerede Scott 5,8 milliarder dollars i velgørende gaver i 2020. Det er et af de største bidrag fra en privatperson til velgørende organisationer på et år<ref name=":3" /><ref>{{Kilde nyheder|url=https://www.thetimes.co.uk/article/jeff-bezos-and-mackenzie-scott-please-stop-giving-youre-making-me-look-bad-02870rtzq|title=Jeff Bezos and Mackenzie Scott: Please stop giving. You're making me look bad|last=Vallely|first=Paul|work=[[The Times]]|access-date=30. december 2020|issn=0140-0460}}</ref>. Hun donerede yderligere 2,7 milliarder dollars i 2021<ref>{{Cite web|title=MacKenzie Scott Is Giving Away Another $2.7 Billion To 286 Organizations|url=https://www.npr.org/2021/06/15/1006829212/mackenzie-scott-is-giving-away-another-2-7-billion-to-286-organizations|access-date=21. juni 2021|website=NPR}}</ref>.
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