[[File:Proteopathy Abeta deposits in Alzheimer disease.jpg|thumb|Et billed af protein-udfældningerne i hjernen fra en patient med [[Alzheimers sygdom]]]]
[[File:Lewy bodies (alpha synuclein inclusions).svg|thumb|Fire billeder af Lewy-legemerne i hjernen fra en patient med [[Parkinsons sygdom]]]]
[[File:Events in alpha synuclein toxicity.jpg|thumb|Skitse af alpha-synuclein, der danner intermolekylære [[protein#Den tertiære struktur|beta-sheets]] ledende til Lewy-legemer]]
'''Proteinfejlfoldnings-sygdom''', '''proteinopati''' eller '''proteopati''' (eng. protein misfolding disease  eller protein conformational disorder) er en klasse af sygdomme, hvor proteiner bliver strukturelt ændret fra det normale for derved at forstyrre, hæmme eller afspore de normale funktioner i celler, væv og organer.<ref>[https://www.nature.com/scitable/topicpage/protein-misfolding-and-degenerative-diseases-14434929/ Protein Misfolding and Degenerative Diseases. Scitable by Nature Education 2010]</ref><ref>[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/proteinopathy Proteinopathy. Science Direct]</ref><ref>[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/proteopathy Proteinopathy. Science Direct 2018]</ref><ref>[https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2006.05181.x Protein-misfolding diseases and chaperone-based therapeutic approaches. FEBS Journal 2006]</ref>
Sygdomme