I USA og Canada forventedes det, at filmen ville indbringe 65-85 USD i den første weekend.<ref>{{Cite news|last=Brueggemann|first=Tom|date=23. september 2021|title=Box Office Recovery Is on the Upswing and James Bond Will Take It Even Higher|work=[[IndieWire]]|url=https://www.indiewire.com/2021/09/box-office-recovery-james-bond-venom-1234666535/|access-date=19. oktober 2021|archive-url=https://web.archive.org/web/20211010193511/https://www.indiewire.com/2021/09/box-office-recovery-james-bond-venom-1234666535/|archive-date=10. oktober 2021}}</ref> Den første dag blev det til 23,3 mio. USD, det hidtil bedste for franchisen.<ref>{{Cite web|last= D'Alessandro |first= Anthony |date= 9. oktober 2021 |title= 'No Time To Die', Daniel Craig's Final Bond Film, Targeting $60M Domestic Opening – Box Office |url= https://deadline.com/2021/10/no-time-to-die-weekend-box-office-1234852700/ |access-date=9. oktober 2021 |website=Deadline|language=engelsk}}</ref> I åbningsweekenden som helhed blev det til 55,2 mio. USD,<<ref>{{Cite web|last1=Eckhouse|first1=Brian|last2=Moore|first2=Brian|date=10. oktober 2021|title=Bond Film Fails to Top U.S. Record, Pulls in $55.2 Million|url=https://www.bloomberg.com/news/articles/2021-10-10/james-bond-film-opens-at-no-1-with-56-million-in-ticket-sales|url-access=subscription|url-status=live|archive-url=https://web.archive.org/web/20211018065314/https://www.bloomberg.com/news/articles/2021-10-10/james-bond-film-opens-at-no-1-with-56-million-in-ticket-sales|archive-date=18. oktober 2021|access-date=16. oktober 2021|website=[[Bloomberg News]]}}</ref>ref>{{Cite web|url=https://www.boxofficemojo.com/weekend/2021W41/?ref_=bo_wey_table_1|title=Domestic 2021 Weekend 41|website=Box Office Mojo}}</ref> hvilket var det bedste i den weekend og det fjerdebedste for franchisen.<ref name=VarietyBE>{{Cite web|last= Rubin |first= Rebecca |date= 10. oktober 2021 |title= Box Office: 'No Time to Die' Debuts Slightly Behind Expectations With $56 Million |url= https://variety.com/2021/film/box-office/box-office-no-time-to-die-opening-weekend-daniel-craig-1235085585/ |access-date=10. oktober 2021 |website=Variety |language=engelsk}}</ref> ''[[Deadline Hollywood]]'' mente, at de undergåede forventninger skyldtes den lange spilletid på 163 minutter, der begrænsede hvor ofte den kunne vises.<ref name=opening>{{Cite web|last= D'Alessandro |first= Anthony |date= 11. oktober 2021 |title= ‘No Time To Die’ Now Seeing $60M+ Over 4-Day Holiday — Monday Update |url= https://deadline.com/2021/10/no-time-to-die-weekend-box-office-1234852700/ |access-date=11. oktober 2021 |website=Deadline Hollywood |language=engelsk}}</ref> ''[[TheWrap]]'' fandt, at premieren var godt nyt for biograferne, for selv hvis filmen ikke tjente sig selv hjem i biograferne, var det et opmuntrende tegn for kommende film for voksne.<ref name="WrapBE">{{Cite web|last=Fuster|first=Jeremy|date=10. oktober 2021|title=Why 'No Time to Die' Opening Is Good News for Theaters – Even if MGM Doesn't Break Even|url=https://www.thewrap.com/no-time-to-die-movie-theaters-older-audiences-mgm/|url-access=limited|url-status=live|archive-url=https://archive.today/20211212223329/https://www.thewrap.com/no-time-to-die-movie-theaters-older-audiences-mgm/|archive-date=12. december 2021|access-date=12. december 2021|website=[[TheWrap]]}}</ref> I den anden weekend, hvor filmen blev slået af den nye ''[[Halloween Kills]]'', blev det til 24,3 mio. USD.<ref>{{Cite web |last=D'Alessandro |first=Anthony |date=17. oktober 2021 |title='Halloween Kills' Grabs Best Horror & R-Rated Opening Records During Pandemic With $50.4M, Even With Peacock Day & Date |url=https://deadline.com/2021/10/halloween-kills-the-last-duel-weekend-box-office-1234856404/ |access-date=17. oktober 2021 |website=Deadline Hollywood |language=engelsk}}</ref>
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