Fra 1923 til sin død 1927 var Lytras leder af kunstmuseet i Athen.<ref name=nationalgallery_4>"... In 1923, Nikos Lytras was elected Professor at the School of Fine Arts over his fellow candidates, Parthenis and Papapanagiotou. During the few years he taught, until his early death in 1927, he managed to breathe new life into the school’s teaching methodology and the organization of its ateliers. Most importantly, his main achievement was bringing the students in touch with new artistic movements." (Fra [https://www.nationalgallery.gr/en/exhibitions/nikos-lytras-chtizontas-me-to-chroma-kai-to-fos "Nikos Lytras, 1883-1927. Building with light and colour"] hos Nationalgallery.gr)</ref>
Maleri