Hooker mødte herefter Yair Rodríguez den 3. oktober 2015 på UFC 192.<ref>{{Kilde nyheder|url=http://www.mmafighting.com/2015/8/3/9092313/yair-rodriguez-vs-dan-hooker-added-to-ufc-192-slate|title=Yair Rodriguez vs. Dan Hooker added to UFC 192 slate|last=Dave Doyle|date=2015-08-03|access-date=2015-08-03|publisher=mmafighting.com}}</ref> Han tabte kampen via enstemmig afgørelse.<ref>{{Cite web|url=http://mmajunkie.com/2015/10/ufc-192-results-yair-rodriguez-sweeps-daniel-hooker-despite-likely-broken-foot|title=UFC 192 results: Yair Rodriguez sweeps Daniel Hooker|publisher=mmajunkie.com|last=Brent Brookhouse|date=2015-10-03|access-date=2015-10-03}}</ref>
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