{| class="wikitable" style="margin-left:1em; text-align:center;"
|-
! style="width:60px;"|Rang.<ref name="atp"/>
! Spiller
| Årsag
! Resultat
|-
| 135
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|GBR|3:2}} [[Andy Murray]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Inviteret af [[Tennis Australia]]<ref>[https://www.theguardian.com/sport/2021/dec/23/andy-murray-accepts-wildcard-to-play-at-2022-australian-open The Guardian - ''Andy Murray accepts wildcard to play at 2022 Australian Open'' (23. december 2021)] {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Anden runde
|-
| 142
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Alex Bolt]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ao_20220108"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 145
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Thanasi Kokkinakis]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ao_20220108"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 159
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|FRA|3:2}} [[Lucas Pouille]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Fédération Française de Tennis|FFT]]<ref>[https://www.lequipe.fr/Tennis/Actualites/Fiona-ferro-et-lucas-pouille-invites-a-l-open-d-australie/1305332 L'Équipe - ''Fiona Ferro et Lucas Pouille invités à l'Open d'Australie'' (14. december 2021)] {{fr sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 160
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Aleksandar Vukic]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ao_20220108">[https://ausopen.com/articles/news/thanasi-kokkinakis-among-ao-wildcard-recipients Australian Open - ''Thanasi Kokkinakis among AO wildcard recipients'' (8. januar 2022)] {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Anden runde
|-
| 168
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Stefan Kozlov]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Vinder af [[USTA]]'s [[wildcard]]-challenge<ref>[https://www.tennis-tourtalk.com/82770/kozlov-earns-australian-open-main-draw-wild-card Tennis Tourtalk - ''Kozlov Earns Australian Open Main Draw Wild Card'' (22. november 2021)] {{Webarchive|url=https://web.archive.org/web/20211123101534/https://www.tennis-tourtalk.com/82770/kozlov-earns-australian-open-main-draw-wild-card |date=23. november 2021 }} {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Anden runde
|-
| 173
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Chris O'Connell]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ao_20220108"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/16}};"|Tredje runde
|-
| 187
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|TPE|3:2}} [[Tseng Chun-Hsin]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Asia-Pacific wildcard<ref>[https://www.theaustralian.com.au/breaking-news/australian-open-2022-sam-stosur-set-to-be-a-topfour-seed-in-the-womens-doubles-as-she-aims-for-more-title-success/news-story/896d85ee34d15fb39288a357b3cdaf77 The Australian - ''Australian Open 2022: Sam Stosur to be a top-four seed in women’s doubles'' (24. december 2021)] {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|}
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