Efter at have vundet 8 kampe i træk på under 2 år, fik Cerrone sin første mulighed for at kæmpe om letvægts-titlen. Han mødte [[Rafael dos Anjos]] i hovedkampen på [[UFC on Fox 17]] on December 19, 2015.<ref>{{cite web|url=http://www.ufc.com/news/Dos-Anjos-vs-Cerrone-II-Headlines-on-Dec-19|title=Dos Anjos vs. Cerrone II Headlines on Dec. 19|author=Thomas Gerbasi|publisher=UFC.com|date=2015-08-13|access-date=2015-08-13|archive-date=11. juli 2018|archive-url=https://web.archive.org/web/20180711022213/http://www.ufc.com/news/Dos-Anjos-vs-Cerrone-II-Headlines-on-Dec-19|url-status=live}}</ref> Cerrone tabte kampen via TKO blot 66 sekunder inde i 1. omgang.<ref>{{cite web|url=http://mmajunkie.com/2015/12/ufc-on-fox-17-results-rafael-dos-anjos-disposes-of-donald-cerrone-in-just-66-seconds|title=UFC on FOX 17 results: Rafael dos Anjos downs Cerrone in 66 seconds, warns McGregor|author=John Morgan|publisher=mmajunkie.com|date=2015-12-19|access-date=2015-12-19|archive-date=11. juli 2018|archive-url=https://web.archive.org/web/20180711031738/https://mmajunkie.com/2015/12/ufc-on-fox-17-results-rafael-dos-anjos-disposes-of-donald-cerrone-in-just-66-seconds|url-status=live}}</ref>
Levende_personer Sport