Der findes endnu ikke definitive beviser på måder at forebygge AD.<ref>Forebyggelsesanbefalinger ikke understøttet:
* {{vcite journal | author = Kawas CH | title = Medications and Diet: Protective Factors for AD? | journal = Alzheimer Disease and Associated Disorders | volume = 20 | issue = 3 Suppl 2 | pages = S89–96 | year = 2006 | pmid = 16917203 | doi=10.1097/00002093-200607001-00014}}
* {{vcite journal | vauthors = Luchsinger JA, Mayeux R | title = Dietary Factors and Alzheimer's Disease | journal = Lancet Neurology | volume = 3 | issue = 10 | pages = 579–87 | year = 2004 | pmid = 15380154 | doi = 10.1016/S1474-4422(04)00878-6 }}
* {{vcite journal | vauthors = Luchsinger JA, Noble JM, Scarmeas N | title = Diet and Alzheimer's Disease | journal = Current Neurology and Neuroscience Reports | volume = 7 | issue = 5 | pages = 366–72 | year = 2007 | pmid = 17764625 | doi = 10.1007/s11910-007-0057-8 }}
* {{cite press release|url=http://www.nih.gov/news/health/apr2010/od-28.htm|title=Independent Panel Finds Insufficient Evidence to Support Preventive Measures for Alzheimer's Disease|date=28. april 2010|publisher=[[National Institutes of Health]]|accessdate= 5. december 2016|archivedate= 2. maj 2010|archiveurl=https://web.archive.org/web/20100502034409/http://www.nih.gov/news/health/apr2010/od-28.htm}}
* {{cite web|url=http://consensus.nih.gov/2010/alzstatement.htm|title=NIH State-of-the-Science Conference: Preventing Alzheimer's Disease and Cognitive Decline|date=26.-28. april 2010|author=Daviglus ML|display-authors=etal|access-date= 5. december 2016|archive-date= 3. maj 2010|archive-url=https://web.archive.org/web/20100503054126/http://consensus.nih.gov/2010/alzstatement.htm|url-status=live}}</ref> Epidemiologiske studier har antydet et forhold mellem bestemte modificerbare faktorer såsom kost, kardiovaskulær risiko, farmaceutiske produkter og intellektuelle aktiviteter på den ene side og en befolknings risiko for at udvikle AD på den anden. Der kræves dog yderligere forskning som kliniske forsøg for at kunne afgøre, om disse faktorer vitterligt kan hjælpe med at forebygge AD.<ref>{{vcite journal | vauthors = Szekely CA, Breitner JC, Zandi PP | title = Prevention of Alzheimer's Disease | journal = International Review of Psychiatry | volume = 19 | issue = 6 | pages = 693–706 | year = 2007 | pmid = 18092245 | doi = 10.1080/09540260701797944 }}</ref>
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