Fisher havde et forhold til skuespilleren Clint Eastwood i seks år i begyndelsen af 1990'erne. I den periode fik parret et barn sammen ved navn [[Francesca Eastwood]] (født 1993).<ref name=LATimes>{{cite news |last=Schenden |first=Laurie K. |title=How's Life After Clint? Look at Frances Fisher's Schedule |url=http://articles.latimes.com/1995-09-15/entertainment/ca-46085_1_frances-fisher |work=[[Los Angeles Times]] |access-date=21. november 2013 |date=15. september 1995 |archive-date= 4. december 2013 |archive-url=https://web.archive.org/web/20131204050724/http://articles.latimes.com/1995-09-15/entertainment/ca-46085_1_frances-fisher |url-status=live }}</ref><ref>{{cite web |last=DeNinno |first=Nadine |title=Francesca Eastwood, Daughter Of Clint Eastwood And Frances Fisher, Named Miss Golden Globe 2013 |url=http://www.ibtimes.com/francesca-eastwood-daughter-clint-eastwood-frances-fisher-named-miss-golden-globe-2013-photos-912058 |work=[[International Business Times]] |access-date=21. november 2013 |archive-date= 4. december 2013 |archive-url=https://web.archive.org/web/20131204041355/http://www.ibtimes.com/francesca-eastwood-daughter-clint-eastwood-frances-fisher-named-miss-golden-globe-2013-photos-912058 |url-status=live }}</ref>
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