== Opvækst ==
Pompeo blev født i [[Everett, Massachusetts]], som datter af Kathleen og Joseph Pompeo.<ref name="tvg">{{cite web | url=https://www.tvguide.com/celebrities/ellen-pompeo/bio/193537 | title=Ellen Pompeo - Biography | publisher=[[TV Guide|TV Guide.com]] | access-date=27. september 2014 | url-status=dead | archive-url=https://web.archive.org/web/20141006080145/http://www.tvguide.com/celebrities/ellen-pompeo/bio/193537 | archive-date= 6. oktober 2014 }}</ref><ref name="People">{{cite news|title=Ellen Pompeo Quietly Weds in New York|url=http://www.people.com/people/article/0,,20160033,00.html|work=[[People (magazine)|People]]|access-date=22. maj 2016|url-status=live|archive-url= https://web.archive.org/web/20160320141145/http://www.people.com/people/article/0,,20160033,00.html|archive-date=20. marts 2016}}</ref> Hendes far var af [[italien]]sk, [[England|engelsk]] og [[Irland|irsk]] afstamning, og hendes mor var af irsk afstamning.<ref>{{cite web |url=http://charlestownbridge.com/2012/09/13/obituaries-09-13-2012/ |title=Obituaries 09-13-2012 &#124; Charlestown Patriot-Bridge |publisher=Charlestownbridge.com |date=13. oktober 2012 |access-date= 11. april 2013 |url-status=live |archive-url=https://web.archive.org/web/20121102050431/http://charlestownbridge.com/2012/09/13/obituaries-09-13-2012/ |archive-date= 2. november 2012 }}</ref><ref>{{cite web |url=http://familytreemaker.genealogy.com/users/t/h/o/Kathe-M-Thoms/WEBSITE-0001/UHP-0161.html |title=Descendants of Mary Coffey and Dennis O'Keefe:Information about Ellen Pompeo |publisher=Genealogy.com |date=10. november 1969 |access-date=11. april 2013 |url-status=live |archive-url=https://web.archive.org/web/20140222021254/http://familytreemaker.genealogy.com/users/t/h/o/Kathe-M-Thoms/WEBSITE-0001/UHP-0161.html |archive-date=22. februar 2014 }}</ref> Hun opvoksede som [[Katolicisme|katolik]].<ref>{{cite web|title=Ellen Pompeo: strength from a challenging early life|url=http://theinneractor.com/67/ellen-pompeo-strength-and-tenacity-from-a-challenging-early-life/|publisher=The Inner Actor|access-date=10. maj 2017|date= 4. november 2015|url-status=live|archive-url=https://web.archive.org/web/20170430175807/http://theinneractor.com/67/ellen-pompeo-strength-and-tenacity-from-a-challenging-early-life/|archive-date=30. april 2017}}</ref> Hendes mor døde af en fejlagtig overdose af smertestillende i 1973, da Pompeo var fire år.<ref>{{cite news|last=Estera|first=Christine|date=24. august 2020|title=Ellen Pompeo talks resentment towards mother who died of an accidental overdose when actress was four|publisher=[[MSN]]|url=https://www.msn.com/en-au/entertainment/celebrity/ellen-pompeo-talks-resentment-towards-mother-who-died-of-an-accidental-overdose-when-actress-was-four/ar-BB18ke6r|access-date=13. november 2020|archive-date=14. november 2020|archive-url=https://web.archive.org/web/20201114034816/https://www.msn.com/en-au/entertainment/celebrity/ellen-pompeo-talks-resentment-towards-mother-who-died-of-an-accidental-overdose-when-actress-was-four/ar-BB18ke6r|url-status=live}}</ref> Hendes far giftede sig på ny kort efter; han døde 1. september 2012.<ref>{{cite web |url=http://www.radaronline.com/exclusives/2012/09/ellen-pompeo-dad-dead-passes-away-joseph |title=Actress Ellen Pompeo's Father Passes Away |publisher=Radar Online |date=6. oktober 2012 |access-date=11. april 2013 |url-status=live |archive-url=https://web.archive.org/web/20130413024541/http://radaronline.com/exclusives/2012/09/ellen-pompeo-dad-dead-passes-away-joseph/ |archive-date=13. april 2013 }}</ref> I 2006 udtalte Pompeo, "Jeg tror, at det at min mor døde så ungt - som 39-årig - har fået mig til at værdsætte livet så meget."<ref>{{cite web|last1=Segatto|first1=Linda|title=10 Things You Probably Didn't Know About Ellen Pompeo of Grey's Anatomy|url=http://www.wetpaint.com/10-things-you-probably-didnt-know-about-ellen-pompeo-of-greys-anatomy-641373/|publisher=[[Wetpaint]]|access-date=10. maj 2017|date=10. maj 2011|url-status=live|archive-url=https://web.archive.org/web/20170625054552/http://www.wetpaint.com/10-things-you-probably-didnt-know-about-ellen-pompeo-of-greys-anatomy-641373/|archive-date=25. juni 2017}}</ref> Hun har fem ældre søskende: tre søstre (Maureen, Kathleen og Suzanne) og to brødre (Joey og Dean). Hun gik under kælenavnene "blyanten" og "[[stracciatella]]" ([[gelato]]-smag).<ref>Bried, Erin. "Anatomy lesson". ''Self''. February 2006</ref> Hun arbejdede som bartender i [[Miami]], hvor hun mødte sin daværende kæreste. De flyttede så til [[New York City]] i 1995, hvor en caster headhuntede hende til at medvirke i reklamer for [[Citibank]] og [[L'Oreal]].<ref name="tvg" /><ref name="hl">{{cite web|title=Ellen Pompeo|date=17. juli 2015|url=http://hollywoodlife.com/celeb/ellen-pompeo/|publisher=[[Hollywoodlife.com]]|access-date=22. maj 2016|url-status=live|archive-url=https://web.archive.org/web/20160528205709/http://hollywoodlife.com/celeb/ellen-pompeo/|archive-date=28. maj 2016}}</ref>
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