Hun har en historie med mentale problemer, selvmordsforsøg og blev misbrugt som barn.<ref>https://eu.usatoday.com/story/life/tv/2017/09/12/sinead-oconnor-tells-dr-phil-her-problems-stemmed-being-flung-into-menopause/659140001/. Sinéad O'Connor tells Dr. Phil her problems stemmed from being 'flung into menopause'. Jayme Deerwester. eu.usatoday.com. Sep 12, 2017.</ref> I 2016 fortalte hun, at hun havde tilbragt 30 dage på et rehabiliteringscenter for at afslutte sit 30 år lange hashmisbrug.<ref>https://www.billboard.com/articles/columns/pop/7556690/sinead-oconnor-completes-30-day-rehab-stint-for-pot-addiction. billboard.com. Sinead O'Connor Completes 30-Day Rehab Stint For Pot Addiction, Moving Into Sober Living Facility. Gil Kaufman. 10/25/2016.</ref>
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