{| class="wikitable" style="margin-left:1em; text-align:center;"
! rowspan="2" style="width:70px;"|Seedning
! colspan="2"|Rangering<ref name="wta">Spillernes rangering på [[WTA's verdensrangliste]] pr. [[. maj]] [[2021]].</ref>
! rowspan="2"|Spillere
! rowspan="2"|Resultat
|-
! style="width:60px;"|Sum
! style="width:60px;"|Ind.
|-
| '''1'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|TPE|3:2}} [[Hsieh Su-Wei]]<br/>{{flagikon|BEL|3:2}} [[Elise Mertens]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/8}};"|Tredje runde
|-
| '''2'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CZE|3:2}} [[Barbora Krejčíková]]<br/>{{flagikon|CZE|3:2}} [[Kateřina Siniaková]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|W}};"|'''Mestre'''
|-
| '''3'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Nicole Melichar]]<br/>{{flagikon|NED|3:2}} [[Demi Schuurs]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/8}};"|Tredje runde
|-
| '''4'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|JPN|3:2}} [[Shuko Aoyama]]<br/>{{flagikon|JPN|3:2}} [[Ena Shibahara]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/16}};"|Anden runde
|-
| '''5'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CHI|3:2}} [[Alexa Guarachi]]<br/>{{flagikon|USA|3:2}} [[Desirae Krawczyk]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Første runde
|-
| '''6'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|TPE|3:2}} [[Chan Hao-Ching]]<br/>{{flagikon|TPE|3:2}} [[Latisha Chan]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/8}};"|Tredje runde
|-
| '''7'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|HUN|3:2}} [[Tímea Babos]]<br/>{{flagikon|RUS|3:2}} [[Vera Zvonarjova]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Første runde
|-
| '''8'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CHN|3:2}} [[Xu Yifan]]<br/>{{flagikon|CHN|3:2}} [[Zhang Shuai]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/16}};"|Anden runde
|-
| '''9'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CAN|3:2}} [[Sharon Fichman]]<br/>{{flagikon|MEX|3:2}} [[Giuliana Olmos]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/8}};"|Tredje runde
|-
| '''10'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CZE|3:2}} [[Lucie Hradecká]]<br/>{{flagikon|GER|3:2}} [[Laura Siegemund]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/8}};"|Tredje runde
|-
| '''11'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CRO|3:2}} [[Darija Jurak]]<br/>{{flagikon|SLO|3:2}} [[Andreja Klepač]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/4}};"|Kvartfinalister
|-
| '''12'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|ROU|3:2}} [[Monica Niculescu]]<br/>{{flagikon|LAT|3:2}} [[Jeļena Ostapenko]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/8}};"|Tredje runde
|-
| '''13'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Ellen Perez]]<br/>{{flagikon|CHN|3:2}} [[Zheng Saisai]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/16}};"|Anden runde
|-
| '''14'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Bethanie Mattek-Sands]]<br/>{{flagikon|POL|3:2}} [[Iga Świątek]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|F}};"|Finalister
|-
| '''15'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Ashleigh Barty]]<br/>{{flagikon|USA|3:2}} [[Jennifer Brady]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Meldte afbud
|-
| '''16'''
| 
| <br/>
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|UKR|3:2}} [[Nadiia Kitjenok]]<br/>{{flagikon|ROU|3:2}} [[Raluca Olaru]]
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/16}};"|Anden runde
|}
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