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| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|ESP|3:2}} [[Carlos Alcaraz]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Skade i højre ben<ref>[https://apnews.com/article/us-open-tennis-championships-sports-carlos-alcaraz-australian-fc4911f461138f8cbb64c6f028146261 Associated Press - ''No. 1 Carlos Alcaraz out of Australian Open with leg injury'' (6. januar 2023)] {{en sprog}}</ref>
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| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CRO|3:2}} [[Marin Čilić]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Knæskade<ref>[https://www.eurosport.com/tennis/australian-open/2023/devastated-marin-cilic-withdraws-from-2023-australian-open-due-to-injury-ahead-of-main-draw_sto9311752/story.shtml Eurosport - ''MARIN CILIC: 'DEVASTATED' TENNIS STAR WITHDRAWS FROM 2023 AUSTRALIAN OPEN DUE TO INJURY AHEAD OF MAIN DRAW'' (11. januar 2023)] {{en sprog}}</ref>
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| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Nick Kyrgios]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Knæskade<ref>[https://sport.tv2.dk/tennis/2023-01-16-kyrgios-traekker-sig-fra-australian-open TV 2 - ''Kyrgios trækker sig fra Australian Open'' (16. januar 2023)] {{en sprog}}</ref>
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