Overeem mødte Andrei Arlovski den 8. maj 2016 på [[UFC Fight Night: Overeem vs. Arlovski|UFC Fight Night 87]]. <ref name="headliner">{{Cite web|url=http://www.mmamania.com/2016/2/20/11078924/alistair-overeem-vs-andrei-arlovski-heavyweight-main-event-set-ufc-fgiht-night-87-rotterdam-mma|title=Alistair Overeem vs Andrei Arlovski heavyweight main event set for UFC Fight Night 87 in Rotterdam|publisher=mmamania.com|last=Brad Popkin|date=20. februar 2016|access-date=20. februar 2016}}</ref> Han vandt kampen via TKO i begyndelsen af anden runde. <ref>{{Cite web|url=http://www.bloodyelbow.com/2016/5/8/11635688/ufc-rotterdam-main-event-result-alistair-overeem-knocks-out-andrei-arlovski|title=UFC Rotterdam main event result: Alistair Overeem knocks out Andrei Arlovski|last=Mookie Alexander|publisher=bloodyelbow.com|date=8. maj 2016|access-date=8. maj 2016}}</ref> Efterfølgende fik han sin første ''Performance of the Night'' bonus. <ref>{{Cite web|url=http://www.sherdog.com/news/news/UFC-Rotterdam-Bonuses-Overeem-Struve-Nelson-de-Randamie-Pocket-3650K-104649|title=UFC Rotterdam bonuses: Overeem, Struve, Nelson, de Randamie pocket $50K|last=Tristen Critchfield|publisher=sherdog.com|date=8. maj 2016|access-date=8. maj 2016}}</ref>
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