Den 31. juli 1999 giftede Dempsey sig med Jillian Fink.<ref name="peoplebio" /> Parret har tre børn, datteren Talula Fink Dempsey <ref name="peoplebio" /><ref name="biographydotcom" /><ref>{{cite news| url=http://www.people.com/people/article/0,26334,1534749,00.html| title=Twin Boys for Patrick Dempsey, Wife| work=[[People (magazine)|People]]| date=20. september 2006| access-date=25. januar 2015| url-status=dead| archive-url=https://web.archive.org/web/20150210021733/http://www.people.com/people/article/0,26334,1534749,00.html| archive-date=10. februar 2015}}</ref> (født 20. februar 2002) og tvillingedrengene Sullivan Patrick Dempsey og Darby Galen Dempsey (født 1. februar 2007).<ref name="dempseychallenge" /><ref name="biographydotcom">{{cite web|title=Patrick Dempsey Biography: Film Actor, Television Actor (1966–)|url=http://www.biography.com/people/patrick-dempsey-201303|publisher=[[Biography.com]] ([[FYI (US TV network)|FYI]]/[[A&E Networks]]|access-date=13. november 2013}}</ref> I januar 2015 søgte Fink om skilsmisse<ref name="people01-2015">{{cite news|url=http://www.people.com/article/patrick-dempsey-wife-files-divorce-greys-anatomy|title=Patrick Dempsey's Wife Files for Divorce|first=Michael|last=Miller|date=23. januar 2015|access-date=25. januar 2015}}</ref> men parret fandt sammen igen samme år.<ref>{{cite web|last1=Lee|first1=Esther|title=Patrick Dempsey, Estranged Wife Jillian Dempsey Are "Trying to Be a Couple Again"|url=http://www.usmagazine.com/celebrity-news/news/patrick-dempsey-estranged-wife-jillian-trying-to-be-a-couple-again-20151011|access-date=10. november 2015}}</ref> De aflyste deres forestående skilsmisse den 12. november 2016.<ref>{{cite news|url=http://www.usmagazine.com/celebrity-news/news/patrick-dempsey-wife-jillian-call-off-divorce-w450144 |title=Patrick Dempsey and Wife Jillian Officially Call Off Divorce |author=Hautman, Nicholas |work=[[US Weekly]] |date=12. november 2016 |access-date=13. november 2016}}</ref>
Levende_personer