Ramaswamy annoncerede sit kandidatur til det republikanske partis præsidentkandidat d. 21. februar 2023. Han startede sin kampagne med at hævde, at USA var midt i en national identitetskrise fremkaldt af, hvad han kaldte "nye sekulære religioner som [[COVID-19|COVID]]-isme, klimaisme og kønsideologi".<ref name="APEntersRace">{{Kilde nyheder|url=https://apnews.com/article/religion-and-politics-united-states-government-2022-midterm-elections-ohio-e1c1cbe47763bd979b6b47557aee043d|title='Woke, Inc.' author Vivek Ramaswamy enters White House race|date=21. februar 2023|work=[[AP News]]|access-date=13. juli 2023|archive-url=https://web.archive.org/web/20230713125113/https://apnews.com/article/religion-and-politics-united-states-government-2022-midterm-elections-ohio-e1c1cbe47763bd979b6b47557aee043d|archive-date=13. juli 2023|quote='Ramaswamy, 37, formally launched his bid by decrying what he called a "national identity crisis" that he claims is driven by a left-wing ideology that has replaced faith, patriotism and hard work with "new secular religions" like climate-ism and gender ideology.' He believes that Americans are given the right to make something of themselves and should not be reliant on the government for providing it for them.}}</ref> Han er også en kritiker af miljømæssige, sociale og corporate governance-initiativer (ESG).<ref name="hilljan21">{{Cite web|last=Gans|first=Jared|date=21. februar 2023|title=Conservative entrepreneur Vivek Ramaswamy announces GOP presidential bid|url=https://thehill.com/homenews/campaign/3868741-conservative-entrepreneur-vivek-ramaswamy-announces-gop-presidential-bid/|url-status=live|archive-url=https://web.archive.org/web/20230224060919/https://thehill.com/homenews/campaign/3868741-conservative-entrepreneur-vivek-ramaswamy-announces-gop-presidential-bid/|archive-date=24. februar 2023|access-date=24. februar 2023|website=[[The Hill (newspaper)|The Hill]]}}</ref><ref name="CincinnatiBC">{{Kilde nyheder|url=https://www.bizjournals.com/cincinnati/news/2021/01/26/a-look-at-the-race-for-portmans-senate-seat-and-a.html|title=A Look At the Race for Portman's Senate Seat|last=Wetterich|first=Chris|date=26. januar 2021|work=[[Cincinnati Business Courier]]|access-date=28. oktober 2021|archive-url=https://web.archive.org/web/20221129043856/https://www.bizjournals.com/cincinnati/news/2021/01/26/a-look-at-the-race-for-portmans-senate-seat-and-a.html|archive-date=29. november 2022}}</ref>
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