[[23. november]] [[1983]] giftede Moore sig med [[Dr. Robert Levine]] på [[Pierre Hotel]] i [[New York City]]. Mary Tyler Moore fik [[Sukkersyge|diabetes]] type 1 i en alder af 33 år.<ref>{{cite web |url=http://www.usatoday.com/life/people/2009-03-22-mtm-diabetes_N.htm|title= Mary Tyler Moore tells how she took control of diabetes  |publisher=USA TODAY |language=Engelsk |access-date=2009-12-30}}</ref> Hun er i dag den international talsperson for [[The Juvenile Diabetes Research Foundation International]] (JDRF). <ref>{{cite web|url=http://www.jdrf.org/index.cfm?page_id=10099|title=Officers, Directors, and Staff (JDRF)|publisher=jdrf.org|language=Engelsk|access-date=2009-12-30|url-status=dead}}</ref>
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