{| class="wikitable" style="margin-left:1em; text-align:center;"
|-
! style="width:60px;"|Rang.<ref name="wta"/>
! Spiller
! Årsag til wildcard
! Resultat
|-
| 117
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|FRA|3:2}} [[Diane Parry]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Fédération Française de Tennis|FFT]]<ref>[https://www.eurosport.fr/tennis/open-d-australie/2022/open-d-australie-2022-diane-parry-herite-de-l-invitation-pour-le-tournoi-apres-la-qualification-dire_sto8675379/story.shtml Eurosport - ''OPEN D'AUSTRALIE 2022 : DIANE PARRY HÉRITE DE L'INVITATION POUR LE TOURNOI APRÈS LA QUALIFICATION DIRECTE DE FIONA FERRO'' (17. december 2021)] {{fr sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 135
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Storm Sanders]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ta_wc"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 137
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|CHN|3:2}} [[Wang Xiyu]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Asia-Pacific wildcard<ref name="ao_20220107"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Anden runde
|-
| 139
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Maddison Inglis]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ta_wc">[https://www.tennis.com.au/news/2021/12/22/first-main-draw-wildcards-announced-for-australian-open-2022 Tennis Australia - ''FIRST MAIN DRAW WILDCARDS ANNOUNCED FOR AUSTRALIAN OPEN 2022'' (22. december 2021)] {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/16}};"|Tredje runde
|-
| 172
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|USA|3:2}} [[Robin Anderson]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Vinder af [[United States Tennis Association|USTA]]'s wildcard-challenge<ref>[https://www.usta.com/en/home/pro/pro-media---news/robin-anderson-earns-spot-in-2022-australian-open-by-winning-wil.html USTA - ''ROBIN ANDERSON WINS AUSTRALIAN OPEN WILD CARD CHALLENGE'' (9. november 2021)] {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 223
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Priscilla Hon]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ao_20220107">[https://ausopen.com/articles/news/ao-main-draw-wildcard-awarded-priscilla-hon Australian Open - ''AO main-draw wildcard awarded to Priscilla Hon'' (7. januar 2022)] {{en sprog}}</ref>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 385
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Daria Saville]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ta_wc"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/64}};"|Første runde
|-
| 480
| style="text-align:left; padding-left:5px; padding-right:20px;"|{{flagikon|AUS|3:2}} [[Samantha Stosur]]
| style="text-align:left; padding-left:7px; padding-right:20px;"|Udpeget af [[Tennis Australia]]<ref name="ta_wc"/>
| style="text-align:left; padding-left:7px; padding-right:20px; background-color:{{Tennisfarve|1/32}};"|Anden runde
|}
Sport