Han instruerede også fortsættelsen til ''[[Blade Runner]]'',<ref>{{cite web | url = http://bloody-disgusting.com/news/3333894/blade-runner-sequel-found-director/ | title = ‘Blade Runner’ Sequel Has Found Its Director! | publisher = bloody-disgusting.com | date = 2015-02-26 | access-date = 2015-10-24 | archive-date = 29. marts 2015 | archive-url = https://web.archive.org/web/20150329004539/http://bloody-disgusting.com/news/3333894/blade-runner-sequel-found-director/ |url-status=live }}</ref> der fik titlen ''[[Blade Runner 2049]]'' og havde som sin berømte forgænger [[Harrison Ford]] i hovedrollen, mens dennes instruktør, [[Ridley Scott]], var producer af fortsættelsen.<ref>{{cite web | url = http://variety.com/2015/film/news/denis-villeneuve-in-talks-to-direct-blade-runner-sequel-1201442794/ | title = Harrison Ford to Return for ‘Blade Runner’ Sequel Directed by Denis Villeneuve | publisher = Variety | date = 2015-02-26 | access-date = 2015-10-24 | archive-date =  8. november 2020 | archive-url = https://web.archive.org/web/20201108115634/https://variety.com/2015/film/news/denis-villeneuve-in-talks-to-direct-blade-runner-sequel-1201442794/ |url-status=live }}</ref>
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