Duhamel begyndte sin skuespilskarriere som statist i musikvideoerne til [[Donna Summer]]s "I Will Go With You ([[Con te partirò]])" og [[Christina Aguilera]]s "[[Genie in a Bottle]]" i 1999.<ref name=USAWeekend>{{cite web|last=Hatty|first=Michele|title=Meet up-and-comer Josh Duhamel|work=[[USA Weekend]]|publisher=[[Gannett Company]]|date=6. februar 2005|url=http://www.usaweekend.com/05_issues/050206/050206josh_duhamel.html|archive-url=https://archive.today/20121216130752/http://www.usaweekend.com/05_issues/050206/050206josh_duhamel.html|url-status=dead|archive-date=16. december 2012|access-date=20. september 2008}}</ref> Josh gik til undervisning hos Scott Sedita Acting Studios. Senere samme år fik han rolle som [[Leo du Pres]] i [[American Broadcasting Company|ABC']] [[sæbeopera]] ''[[All My Children]]''. Hans arbejde i serien, især hans karakters forhold til [[Greenlee Smythe]] (spillet af [[Rebecca Budig]]), modtog roser.<ref name="SoapOperaDigest.com">{{cite news|title=Best New Couple|work=[[Soap Opera Digest]]|year=2000}}</ref><ref name="eyeonsoaps.net">{{cite web|first=Carolyn |last=Aspenson |title=Redefining the Super Couple |publisher=eyeonsoaps.net |date=5. februar 2009 |access-date=5. marts 2009 |url=http://eyeonsoaps.net/wp/?p=1765 |archive-url=https://web.archive.org/web/20090627112608/http://eyeonsoaps.net/wp/?p=1765 |archive-date=27. juni 2009 |url-status=dead}}</ref> I 2000 poserede han fuldstændig nøgen i [[Greg Gorman]]s fotografiske bog ''As I See It.''
Levende_personer