Palo Alto Networks blev etableret i 2005 af Nir Zuk<ref>{{cite web | last=Blacharski | first=Dan | title=How I Got Here: Nir Zuk, CTO, Palo Alto Networks | website=[[ITworld]] | date=2010-04-05 | url=https://www.itworld.com/article/2756415/careers/how-i-got-here--nir-zuk--cto--palo-alto-networks.html | access-date=2018-03-11 | archive-date=13. februar 2019 | archive-url=https://web.archive.org/web/20190213224355/https://www.itworld.com/article/2756415/careers/how-i-got-here--nir-zuk--cto--palo-alto-networks.html | url-status=dead }}</ref>  en tidligere ingeniør fra [[Check Point]] og [[NetScreen Technologies]].<ref>{{Cite web | title = US and UK gov cyber defences = big boys' trough-slurp | url = https://www.theregister.co.uk/2010/10/22/firewall_guru_interview/ | work  =[[The Register]] | date = 22. oktober 2010  | access-date = 8. september 2014 |first=John |last=Leyden}}</ref>
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