Why is my HCV infection not healing inspite of using pegasys with ribavirin therapy?
Patient: helloi m a lady of 32 years having hcv infection from last one year.my hieght is 5,8 and my wieght is 61.i have used pegasys with ribavirin theraphy for 6 months but virus is still present.at the end virus count goes down to 2184.but now its 16 lakhs raised.i want to concieve a baby now bcoz i m having only one baby.my latest test shows ALT-75 and viral load is 16 lakhs.so wht should i do now and wht would u suggest.plz reply me. Doctor: Hi You have not mentioned the genotype of HCV infection u have. Treatment guidelines of hepatitis C have been changed recently.Most important thing in HCV treatment is sustained virologic response [SVR], which is persistent absence of HCV RNA in serum 6 months or more after completing antiviral treatment. As you taken course for 6 month, you must have infection with HCV genotype of 2 or 3. According to latest guidelines, the recommendations for patients with prior PEG Interferon/Ribavirin treatment failure:Genotype 2: Sofosbuvir with Ribavirin for 12 weeks (an alternative is Sofosbuvir with PEG Interferon/Ribavirin for 12 weeks).Genotype 3: Sofosbuvir with Ribavirin for 24 weeks (an alternative is Sofosbuvir with PEG Interferon/Ribavirin for 12 weeks).  You should consult Gastroenterologist. It is important to know you that Ribavirin is teratogenic.Take care.