What dosage of acitrom is needed for normal prothrombin time/international normalized ratio?
Patient: I am a 45 years old male with coronary artery disease.I was on acitrom dose of 1/1/2 mg but that didnot work out as now my PT/INR values are 111.5/ 8.69.Now the doctor has told me to stop taking acitrom.According to pharmacogenetic testing of acitrom for VKORC1 &CYP2C9 gene,I am responder for VKORC1 gene, normal metabolizer for CYP2C9*2 and poor metabolizer for CYP2C9 *3.So now what dosage will be approprate for me to maintain normal range of PT/INR? Doctor: Hallo... acitrom one dose can not be told ...we usually titrate dose .. every weekly ...once stable inr is there ...once we do every 4-6 wk inr ...some pt on 1mg dose achieve targeted inr but some pt ..  require higher doses.    Just monitoring frequently to keep inr in range and titrate dose