What can cause elevated ALT and AST levels?
Patient: Why does my ALT & AST keep going up I have lung cancer but its been shrinking. I have been doing well, my numbers have been up since I ve had the last 3 months of this amuno therapy they drop a little and yet they can t keep it down in order to give me a new med, so they put me on Prednisone and that does t seem to be working all that good is there a natural solution I thought I ate pretty good fish veggies fruit lots of water I just don t want this cancer to start to grow again now that I have been through all the treatments of chemo down to the amuno therapy they won t give me any meds unless my liver enzymes drop, its my ALT & AST Doctor: Hello,  Liver enzymes may be raised because of various causes. In your case, some may be more possible but in every case it requires evaluation of the cause.   Most common causes of such liver derangement's are Alcohol, Viral hepatitis, Non-alcoholic fatty liver disease, Drugs.  Gamma GT is most commonly raised due to alcohol intake and in case you take alcohol, you need to keep a control over it.  If you don't take it, you need following tests: hepatitis virus markers, Ultrasound Abdomen and HIDA scan.   A lot many times, liver dysfunction is due to Non-Alcoholic Fatty Liver Disease (NAFLD).   So, if you have any evidence of fatty liver in Ultrasound and your other tests are negative, this rise is liver enzyme would be attributed to NAFLD. For this you need to reduce your weight, reduce fat in diet.   Hope I have answered your query. Let me know if I can assist you further.  Take care  Regards, Dr Ivan R. Rommstein, General Surgeon