Have thyroid disease and kidney insufficiency. Taken Methamazole. Elevated liver enzymes after PTU. Any ideas?
Patient: I am a 58 year old female with thyroid disease and recently diagnosed kidney insufficiency.  I did a six-month course of methamazole which treated the hyperthyroidism however my GFR dropped to 44 while on the drug.  They stopped the methamazole and my GFR came up to 54.  They started PTU for the hyperthyroidism and now my GFR is back down to 44, and my liver enzymes are elevated.  An ultrasound shows bi-lateral hydronephrosis.  My GP is now sending me to a urology surgeon for evaluation.  Any ideas on what is going on? Doctor: Hi, the drugs you are using are showing hepatotoxicity, and renal toxicity, as you are recovering after stopping the drugs, after consulting the nephrologist you better stop the drugs, or change to some other alternative for hyperthyroidism. Thank you.