Son is non-verbal autistic man. On Naltrexone. Lower doses were working fine for him. When dose increased has abnormal behavior. Suggestions?
Patient: Hello, my son Max 19yrs old non-verbal autistic man is taking Naltrexone started with 50 mg and innow increased to 200 mg  advice by his psychaitrist to treat agression behavior . It was working quite well during lower doses. Now, he developed agression behavior like hit the wall and left hole, very confusing, emotional/upset easily without reasons, problem sleep, look depress, nausea and vomiting,press cough, tiredness , lost interest of any kind of activity, requested more sleep...I try to contact his psychaitrist but he 's away...my question : should I reduce the doses ? Thanks for advance Doctor: Hi, Individuals on Naltrexone, that is used to reduce self injurious and autistic behaviors in autism, have reported feeling fatigued, tired, and listless. Some individuals have reported an increase in irritability, restlessness, mental confusion, and slowing following naltrexone administration. If he was maintaining well on lower doses then you can reduce the dose till his psychiatrist returns and then discuss it with him. Do not do it abruptly, it has to be done in small increments. If you do not feel confident to do it yourself then consult another psychiatrist. Hoe this helps, Dr Anjana rao