Having asthma, depression. Taking fostair, duloxetine, Zomorph, rivaroxaban. Treated with omeprazole. What are the risks and interactions between all these drugs?
Patient: I am taking fostair for asthma, duloxetine long term for depression, Zomorph 60mg daily recently reduced from 80mg daily, with naproxen recently added in to get me off opiates,  I have been on opiate drugs long term also for hip and back trouble and have just had a hip replaced, I am also taking rivaroxaban. In the past I have been endoscoped and gastric lesions were found and treated with omeprazole. It is documented in my gp's notes that I have abnormally low blood pressure and that I buise easily. I am bruising easily again and was treated last week for a suspected blood clot, but I am worried about a) interactions between all these drugs I am taking and b) the risk of a bleed somewhere and c) an asthma attack. Can you advise me what are the risks? Generally I am feeling just unwell weak and a bit wobbly. The hip replacement was done on 3rd April this year and we think the other one will have to be replaced soon, i am female aged 46 Doctor: Hello, Thanks for the query to H.C.M.Forum.Here I want to tell you that ZOMORHP tablets causes respiratory depression and in asthma there is respiratory depression.Fostair's ingredients are beclo+ antihistamine and when this drug is to be taken with antidepressant (duloxetine) than there are chances of cardiac arrhythmias ,so be aware about that.You are also using anticoagulants  along omeprazoel.Omeprazole enhances the  effects of rivaroxaban because it( omeprazole reduces excretion of rivaroxaban, so keep this thing in mind.  2.Risk of bleeding is there because of interaction of these drugs.3.An asthmatic  attack's chances are more due to drugs interaction.So please take drugs in such a way that at least 3-4 hours gape remains in between them.Good luck , hope you will recover from all diseases.Dr. HET