What causes sudden tightening of the chest?
Patient: Recently while driving through the mountains in Pennsylvania I felt a strong tightness in my chest.  I was on HRT in the fall, but was taken off because of loss of eye sight in one eye...also had this tightening in my chest.  Since then I have been fine...up until now.  What do you think? Doctor: Respected user, hi I evaluated your query thoroughly.* Relates to decreased lung oxygenation at heights in mountains causing    sudden tightening of the chest , a normal physiological phenomenon   observed in majority of people without any underlying pathology.Hope this helps you.Welcome for any further assistance.Thanks for using Healthcaremagic.com & giving me an opportunity to assist you.Wishing you a very happy healthy life ahead.Regards dear take care.