What do painful lumps on the fingers while on Plaquenil indicate?
Patient: I have been on Plaquenil for several years and I am getting many nodules on my fingers that are increasingly growing in size and causing pain and discomfort.  My Dr. says it's unusual since I'm not on Methotrexate.  When I was on Remicade they went away but I got a serious infection on Remicade and ended up with sepsis.Do you have any suggestions? Doctor: Hello,Painful lumps on the fingers indicate possible alterations at microcellular level with fibrous tissue changes to certain areas of the body. A better insight can be possible with a detailed history, physical examination and certain basic lab tests.Hope I have answered your query. Let me know if I can assist you further.Regards,Dr. Bhagyesh V. Patel