Could neck lump pain, muscle and joint pain be due to lupus?
Patient: hi for a while now i ve been having many symptoms that first began with neck pain a while back (2 years ago ) with lump not visable (to the touch ) recently i ve been having ( ankle knee elbow back shoulder wrist finger neck hip joint pain and calf arm thigh etc. muscle pain mri cat scan and emg came back normal blood work came back abnormal liver functions insomia fatuige headaches ( doctor said about mid range ) tested ana came back postive then had a ra factor neg. then a ana profile (FANA was 1:80 speckled ) i think sedrate and crp was normal my question is what are the possiblities that i could have lupus or another autoimmune problem if its possible what should i consider to my doctor to test for more info : im a white male age 21 pain would be a 9 (chronic ) more than few months Doctor: Hi,Thank you for your query. I can understand your concerns.Antinuclear Antibody (ANA)-Primary disease     association (sensitivity, specificity):SLE(>95 %,low).often used as screening test; a negative test virtually excludes SLE; a positive test while non-specific, increases post-test probability of SLE. Titer does not correlate with disease activity.     Other disease association with positive ANA:rheumatoid arthritis(30-50 %),discoid lupus,scleroderma(60 % ),drug-induced lupus(100 %),Sjogren's syndrome(80 %),miscellaneous inflammatory disorders.Do test for Anti-double- stranded DNA/anti-ds-DNA (sensitivity, specificity):SLE ( 60-70 %,high )& Anti-Smith antibody/anti-Sm (sensitivity, specificity):SLE (30-40 %,high ).The specificity of Anti-smith & Anti-double stranded DNA for Systemic lupus erythemtosus (SLE )ranges from 55 -100%.Regards Dr. T.K. Biswas M.D.Mumbai