Can use of Hydrea cause dark grey spots on the tongue and dark skin discoloration?
Patient: Hi, my name is XXXX. I have primary myelofibrosis and currently treated with 2 gr of Hydrea everyday due to high platelets. I had splenectomy 4 months ago and have been on penicillin everyday since the surgery. Now I venoticed that I have dark grey spots in my tongue, do you know what has caused these spots? I know Hydrea has caused my hand skin and nail become darker but I haven t read/heard that hydrea causes dark tongue too. thanka so much. Really appreciate your answer. XXXX Doctor: Hi,Hydrea can cause blackening of the fingernails and toenails however it is not known to cause dark grey spots on the tongue. It may be related to poor oral hygiene, low saliva production, liquid diet, and use of antibiotics. It can be prevented by brushing your tongue using a soft toothbrush, Brush after eating and drinking coffee, tea, and alcohol.Hope I have answered your query. Let me know if I can assist you further.  Regards, Dr. Mohammed Taher Ali, General & Family Physician