Can taking high dosage of niaspan result in red rashes and swelling on skin?
Patient: I have been taking Niaspan er 1000mg for a few years.  Last summer I came down with a terrible rash (redness on my face and neck) Went to dermatologist who gave me meds and it subsided (cleared.)  Also went to allergist for tests and info at the same time. Now, this condition has returned with a vengeance.  My face is red/swollen somewhat and burning.  The skin flakes on my face and this rash has moved to include my right arm and hand. Before I go for my next doctor(s) visits:  could this possibly be a reaction of taking Niaspan in such a high dose and for so long?  I do take an aspirin as prescribed for the "flushing" but this is an unusual rash. Thank you.Pauline Witriol (age 77) Doctor: Hi,After reading your query the closest possibility of your problem appears to be "allergic dermatitis". This is a condition caused by bursting of allergy producing cells known as "mast cells" due to contact of certain allergens. As the chemical inside them is released causes the kind of rash which you mentioned. There are many factors inducing the increased number and activity of these cells.Kindly follow the suggestions below:-Apply fluticasone cream 2 times a day.-You can do cold water compresses to reduce the intensity of itching.-Do not scratch or rub the skin as it can lead to further aggravation.You can take oral anti histamine like loratadine or levocetrizine under medial advise. Despite above measures if the problem is not getting better then it is better to consult a dermatologist for best guidance.Hope these informations will help.