Is anxiety a side effect of taking Trazodone with Buspirone?
Patient: I was recently prescribed Trazadone 50mg for insomnia and two daily doses of Buspirone 5mg for anxiety. In looking at the side effects, I read that there is the possibility of an adverse drug interaction. This, of course, has increased my anxiety. I hope you can help. Thank you. Doctor: Hello,  It should not. Using busPIRone together with traZODone can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred visible.  Hope I have answered your query. Let me know if I can assist you further.  Take care  Regards, Dr AJEET SINGH, General & Family Physician