What does 1-86 kappa lambda ratio indicate?Suggest further course of action
Patient: Dear Dr. Indranil Ghosh, As per advise of doctors in medanta hospital and as suggested by you, We ve got 4th cycle of chemotherapy (Bort-Dex) completed. After which doctor prescribed for tests Serum free light chain, CFC & KFT. I ve attached the report. Please have a look. Last Serum free light chain was done 1 month back after 3rd cycle which showed Kappa\Lambda ratio to be normal (0.88). But this time after 4th cycle kappa lambda ratio is increased to 1.86. Doctor here will be putting her on maintainace after reviewing the reports. Please suggest what does the current report indicate and further course of action? Thanks, Bhuwan Grover Doctor: HiSerum free light chain (SFLC) testing is ordered to help detect, diagnose, and monitor plasma cell disorders (dyscrasias),Light chains are proteins produced by plasma cells. They are used to assemble immunoglobulins (Ig), antibodies that target and neutralize specific threats to the body such as bacteria and viruses. Two light chains and two heavy chains combine to form an immunoglobulin,With a group of conditions called plasma cell disorders or monoclonal gammopathies, a plasma cell becomes malignant, divides uncontrollably, and produces large amounts of an abnormal monoclonal immunoglobulin (M-protein). This protein may take the form of an intact immunoglobulin or of one of its component parts – a kappa or lambda light chain,Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of approximately 0.26 to 1.65.right now its 1.86 which is elevated so follow the treatment as suggested by oncologist and attach all details for further comments