Is it safe to take doxycycline hyclate and rifampin together?
Patient: Is it o.k to take doxycycline hyclate and rifampin at the same time? I have just been diagnosed with MRSA. i HAD A TOTAL KNEE REPLACEMENT IN JANUARY BUT THE INCISION HAS NEVER HEALED. FINALLY, MY DEMATOLOGIST TOOK A CULTURE AND I JUST GOR THE RESULTS NOW. Doctor: Hi,It is not safe to take these two antibiotics together. Rifampin is one of the most powerful liver enzyme inducers which if given along with doxycycline will increase its metabolism and increase its clearance from the body thus decrease the effects of doxycycline. Contact your doctor for a dose adjustment of these medications or to prescribed alternate effective antibiotics for the eradication of MRSA.Hope I have answered your question. Let me know if I can assist you further.  Regards, Dr. Mohammed Taher Ali, General & Family Physician