Is Hydrocodone safe to be taken while on Tramadol?
Patient: I recently began taking Hydro, 5-325mg, for pain. My question is I am already taking Tramadol, 50mg, was supplimenting it w/Tylenol, but not getting much relief. I have stopped the Tylenol, of course, but is it ok to take the Hydro & Tramadol together? Alone neither of them help much. Doctor: Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.  You can take Hydrocodone and Tramadol together. They won’t interact with each other as it doesn’t produce any adverse reactions. Keep in mind that you may feel excessive sleepiness while combining these two drugs.  Wishing you good health.  Thanks.