Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Predicting Clinical Outcomes in Glioblastoma: An Application of
  Topological and Functional Data Analysis   Glioblastoma multiforme (GBM) is an aggressive form of human brain cancer
that is under active study in the field of cancer biology. Its rapid
progression and the relative time cost of obtaining molecular data make other
readily-available forms of data, such as images, an important resource for
actionable measures in patients. Our goal is to utilize information given by
medical images taken from GBM patients in statistical settings. To do this, we
design a novel statistic---the smooth Euler characteristic transform
(SECT)---that quantifies magnetic resonance images (MRIs) of tumors. Due to its
well-defined inner product structure, the SECT can be used in a wider range of
functional and nonparametric modeling approaches than other previously proposed
topological summary statistics. When applied to a cohort of GBM patients, we
find that the SECT is a better predictor of clinical outcomes than both
existing tumor shape quantifications and common molecular assays. Specifically,
we demonstrate that SECT features alone explain more of the variance in GBM
patient survival than gene expression, volumetric features, and morphometric
features. The main takeaways from our findings are thus twofold. First, they
suggest that images contain valuable information that can play an important
role in clinical prognosis and other medical decisions. Second, they show that
the SECT is a viable tool for the broader study of medical imaging informatics.

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The categories of this paper are: hep-ph
21
The categories of this paper are: adap-org
20
The categories of this paper are: acc-phys
14
The categories of this paper are: math-ph
25
The categories of this paper are: patt-sol
4
The categories of this paper are: cond-mat
9
The categories of this paper are: nlin
18
The categories of this paper are: econ
31
The categories of this paper are: ao-sci
30
The categories of this paper are: q-alg
35
The categories of this paper are: mtrl-th
23
The categories of this paper are: solv-int
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The categories of this paper are: hep-th
22
The categories of this paper are: chao-dyn
10
The categories of this paper are: q-bio
15
The categories of this paper are: nucl-ex