Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Structure-activity mapping of the force- and sequence-dependent landscape of T cell activation Adaptive immunity relies on T lymphocytes that use {beta} T-cell receptors (TCRs) to discriminate amongst peptides presented by MHC molecules (pMHCs). An enhanced ability to screen for pMHCs capable of inducing robust T-cell responses could have broad applications in diagnosing and treating immune diseases. T cell activation relies on biomechanical forces to initiate triggering of the TCR. Yet, most in vitro screening technologies for antigenic peptides test potential pMHCs for T cell binding without force and thus are often not predictive of activating peptides. Here, we present a technology that uses biomechanical force to initiate T cell triggering in high throughput. BATTLES (Biomechanically-Assisted T-cell Triggering for Large-scale Exogenous-pMHC Screening) displays candidate pMHCs on spectrally encoded  smart beads capable of applying physiological loads to T cells, facilitating exploration of the force- and sequence-dependent landscape of T-cell responses. BATTLES can be used to explore basic T-cell mechanobiology and T cell-based immunotherapies.
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The categories of this paper are: bioinformatics
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The categories of this paper are: ecology
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The categories of this paper are: biology
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The categories of this paper are: education
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The categories of this paper are: genomics
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The categories of this paper are: molecular
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The categories of this paper are: microbiology
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The categories of this paper are: evolutionary
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The categories of this paper are: cognition
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The categories of this paper are: physiology
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The categories of this paper are: behavior
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The categories of this paper are: toxicology
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The categories of this paper are: scientific
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The categories of this paper are: biochemistry
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The categories of this paper are: developmental
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The categories of this paper are: epidemiology