Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Mechanisms of damage prevention, signalling, and repair impact the ability of Drosophila to tolerate enteric bacterial infection The insect gut is frequently exposed to pathogenic threats and must not only clear these potential infections, but also tolerate relatively high microbe loads. In contrast to the mechanisms that eliminate pathogens, we currently know less about the mechanisms of disease tolerance. We investigated how well-described mechanisms that either prevent, signal, control, or repair damage during infection contribute to the phenotype of disease tolerance. We established enteric infections with the bacterial pathogen Pseudomonas entomophila in transgenic lines of Drosophila melanogaster fruit flies affecting dcy (a major component of the peritrophic matrix), upd3 (a cytokine-like molecule), irc (a negative regulator of reactive oxygen species) and egfr1 (epithelial growth factor receptor). Flies lacking dcy experienced the highest susceptibility, while loss of function of either irc or upd3 reduced tolerance in both sexes. The disruption of egfr1 resulted in a severe loss in tolerance in male flies but had no substantial effect on the ability of female flies to tolerate P. entomophila infection, despite carrying greater microbe loads than males. Together, our findings provide evidence for the role of damage limitation mechanisms in disease tolerance and highlight how sex differences in these mechanisms could generate sexual dimorphism in disease tolerance.
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The categories of this paper are: biochemistry
7
The categories of this paper are: ecology
10
The categories of this paper are: and
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The categories of this paper are: cancer
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The categories of this paper are: microbiology
12
The categories of this paper are: behavior
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The categories of this paper are: epidemiology
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The categories of this paper are: pharmacology
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The categories of this paper are: pathology
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The categories of this paper are: communication
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The categories of this paper are: toxicology
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The categories of this paper are: cell
1
The categories of this paper are: bioinformatics
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The categories of this paper are: cognition
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The categories of this paper are: developmental
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The categories of this paper are: plant