Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A network-based drug repurposing approach identifies new treatment opportunities for the systemic chronic inflammation underlying multiple complex diseases Complex diseases are associated with a wide range of cellular, physiological, and clinical phenotypes. To advance our understanding of disease mechanisms and our ability to treat these diseases, it is critical to delineate the molecular basis and therapeutic avenues of specific disease phenotypes, especially those that are associated with multiple diseases. Inflammatory processes constitute one such prominent phenotype, being involved in a wide range of health problems including ischemic heart disease, stroke, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, and autoimmune and neurodegenerative conditions. While hundreds of genes might play a role in the etiology of each of these diseases, isolating the genes involved in the specific phenotype (e.g. inflammation "component") could help us understand the genes and pathways underlying this phenotype across diseases and predict potential drugs to target the phenotype. Here, we present a computational approach that integrates gene interaction networks, disease-/trait-gene associations, and drug-target information to accomplish this goal. We apply this approach to isolate gene signatures of complex diseases that correspond to chronic inflammation and prioritize drugs to reveal new therapeutic opportunities.
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The categories of this paper are: biophysics
28
The categories of this paper are: communication
7
The categories of this paper are: ecology
21
The categories of this paper are: toxicology
2
The categories of this paper are: biology
29
The categories of this paper are: education
32
The categories of this paper are: zoology
12
The categories of this paper are: behavior
26
The categories of this paper are: biochemistry
5
The categories of this paper are: cell
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The categories of this paper are: immunology
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The categories of this paper are: genomics
15
The categories of this paper are: developmental
30
The categories of this paper are: scientific
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The categories of this paper are: animal
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The categories of this paper are: and