Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Configurational space continuity and free energy calculations   Free energy is arguably the most importance function(al) for understanding of
molecular systems. A number of rigorous and approximate free energy
calculation/estimation methods have been developed over many decades. One
important issue, the continuity of an interested macrostate (or path) in
configurational space, has not been well articulated, however. As a matter of
fact, some important special cases have been intensively discussed. In this
perspective, I discuss the relevance of configurational space continuity in
development of more efficient and reliable next generation free energy
methodologies.

6
The categories of this paper are: astro-ph
15
The categories of this paper are: nucl-ex
20
The categories of this paper are: acc-phys
9
The categories of this paper are: nlin
33
The categories of this paper are: plasm-ph
34
The categories of this paper are: chem-ph
30
The categories of this paper are: q-alg
35
The categories of this paper are: mtrl-th
36
The categories of this paper are: cmp-lg
2
The categories of this paper are: math
21
The categories of this paper are: adap-org
25
The categories of this paper are: patt-sol
17
The categories of this paper are: q-fin
1
The categories of this paper are: cs
10
The categories of this paper are: q-bio
32
The categories of this paper are: atom-ph