Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Frequency band coupling with high-frequency activities during seizures shifts from θ band in tonic phase to δ band in clonic phase ObjectiveTo clarify variations in the relationship between high-frequency activities (HFAs) and low-frequency bands from the tonic to the clonic phase in focal to bilateral tonic-clonic seizures (FBTCS), using phase-amplitude coupling.

MethodsThis retrospective study enrolled six patients with drug-resistant focal epilepsy who underwent intracranial electrode placement for presurgical invasive electroencephalography at Osaka University Hospital (July 2018-July 2019). We used intracranial electrodes to record seizures in focal epilepsy (11 FBTCS). The magnitude of synchronization index (SIm) and receiver-operating characteristic (ROC) analysis were used to analyze the coupling between HFA amplitude (80-250 Hz) and lower frequencies phase.

ResultsThe {theta} (4-8 Hz)-HFA SIm peaked in the tonic phase, whereas the {delta} (2-4 Hz)-HFA SIm peaked in the clonic phase. ROC analysis indicated that the {delta}-HFA SIm discriminated well the clonic from the tonic phase.

ConclusionsThe main low-frequency band modulating the HFA shifted from the {theta} band in the tonic phase to the {delta} band in the clonic phase.

SignificanceIn FBTCS, low-frequency band coupling with HFA amplitude varies temporally. Especially, the {delta} band is specific to the clonic phase. These results suggest dynamically neurophysiological changes in the thalamus or basal ganglia throughout FBTCS.

HighlightsO_LIThe {theta} band (4-8 Hz) was mainly coupled with high-frequency activity (HFA) in the tonic phase of focal to bilateral tonic-clonic seizures (FBTCS).
C_LIO_LIThe {delta} band (2-4 Hz) was mainly coupled with HFA in the clonic phase of FBTCS.
C_LIO_LIThe magnitude of the synchronization index related to {delta}-HFA phase-amplitude coupling discriminated well the clonic from the tonic phase.
C_LI
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The categories of this paper are: animal
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The categories of this paper are: cognition
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