Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Growth inhibition of Akkermansia muciniphila by a secreted pathobiont sialidase Akkermansia muciniphila is considered a key constituent of a healthy gut microbiota. In inflammatory bowel disease (IBD), A. muciniphila has a reduced abundance while other, putative pathogenic, mucus colonizers bloom. We hypothesized that interbacterial competition may contribute to this observation. By screening the supernatants of a panel of enteric bacteria, we discovered that a previously uncharacterized Allobaculum species potently inhibits the growth of A. muciniphila. Mass spectrometry analysis identified a secreted Allobaculum sialidase as inhibitor of A. muciniphila growth. The sialidase targets sialic acids on casein O-glycans, thereby altering the accessibility of nutrients critical for A. muciniphila. The altered glycometabolic niche results in distorted A. muciniphila cell division and efficiently arrests its growth. The identification of a novel mechanism of A. muciniphila growth inhibition by a competing bacterial pathobiont may provide a rationale for interventions aimed at restoring and maintaining a healthy microbiota symbiosis in patients with intestinal disease.
28
The categories of this paper are: communication
24
The categories of this paper are: cancer
19
The categories of this paper are: epidemiology
0
The categories of this paper are: genetics
8
The categories of this paper are: genomics
17
The categories of this paper are: molecular
12
The categories of this paper are: behavior
1
The categories of this paper are: bioinformatics
18
The categories of this paper are: systems
5
The categories of this paper are: cell
26
The categories of this paper are: biochemistry
7
The categories of this paper are: ecology
14
The categories of this paper are: biophysics
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The categories of this paper are: immunology
3
The categories of this paper are: evolutionary
15
The categories of this paper are: developmental