Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Controlling DNA Tug-of-War in a Dual Nanopore Device   Methods for reducing and directly controlling the speed of DNA through a
nanopore are needed to enhance sensing performance for direct strand sequencing
and detection/mapping of sequence-specific features. We have created a method
for reducing and controlling the speed of DNA that uses two independently
controllable nanopores operated with an active control logic. The pores are
positioned sufficiently close to permit co-capture of a single DNA by both
pores. Once co-capture occurs, control logic turns on constant competing
voltages at the pores leading to a `tug-of-war' whereby the molecule is pulled
from both ends by opposing forces. These forces exert both conformational and
speed control over the co-captured molecule, removing folds and reducing the
translocation rate. When the voltages are tuned so that the electrophoretic
force applied to both ends of the molecule comes into balance, the life-time of
the tug-of-war state is limited purely by diffusive sliding of the DNA between
the pores. We are able to produce a tug-of-war state on 76.8% of molecules that
are captured with a maximum two-order of magnitude increase in average pore
translocation time relative to the average time for single-pore translocation.
Moreover, we quantify the translocation slow-down as a function of voltage
tuning and show that the slow-down is well described by a first passage
analysis for a one-dimensional sub-diffusive process. The ionic current of each
nanopore provides an independent sensor that synchronously measures a different
region of the same molecule, enabling sequential detection of physical labels,
such as mono-streptavidin tags. With advances in devices and control logic,
future dual-pore applications include genome mapping and enzyme-free
sequencing.

17
The categories of this paper are: q-fin
29
The categories of this paper are: funct-an
13
The categories of this paper are: quant-ph
0
The categories of this paper are: hep-ph
18
The categories of this paper are: econ
4
The categories of this paper are: cond-mat
23
The categories of this paper are: solv-int
21
The categories of this paper are: adap-org
22
The categories of this paper are: chao-dyn
5
The categories of this paper are: gr-qc
24
The categories of this paper are: dg-ga
9
The categories of this paper are: nlin
11
The categories of this paper are: hep-lat
16
The categories of this paper are: stat
1
The categories of this paper are: cs
30
The categories of this paper are: q-alg