Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Modeling the Effect of Blunt Impact on Mitochondrial Dysfunction in
  Cartilage   Mounting evidence for the role of oxidative stress in the degeneration of
articular cartilage after an injurious impact requires our modeling &
simulation efforts to temporarily shift from just describing the effect of
mechanical stress and inflammation on osteoarthritis (OA). The hypothesis that
the injurious impact causes irreversible damage to chondrocyte mitochondria,
which in turn increase their production of free radicals, affecting their
energy production and their ability to rebuild the extracellular matrix, has to
be modeled and the processes quantified in order to further the understanding
of OA, its causes, and viable treatment options. The current article presents a
calibrated model that captures the damage oxidative stress incurs on the cell
viability, ATP production, and cartilage stability in a cartilage explant after
a drop-tower impact. The model validates the biological hypothesis and will be
used in further efforts to identify possibilities for treatment and be a part
of a bigger modeling & simulation framework for the development of OA.

2
The categories of this paper are: math
17
The categories of this paper are: q-fin
25
The categories of this paper are: patt-sol
36
The categories of this paper are: cmp-lg
4
The categories of this paper are: cond-mat
24
The categories of this paper are: dg-ga
29
The categories of this paper are: funct-an
20
The categories of this paper are: acc-phys
37
The categories of this paper are: supr-con
11
The categories of this paper are: hep-lat
19
The categories of this paper are: eess
33
The categories of this paper are: plasm-ph
0
The categories of this paper are: hep-ph
1
The categories of this paper are: cs
13
The categories of this paper are: quant-ph
22
The categories of this paper are: chao-dyn