Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: In Vitro Vascularized Tumor Platform for Modeling Tumor-Vasculature
  Interactions of Inflammatory Breast Cancer   Inflammatory breast cancer (IBC), a rare form of breast cancer associated
with increased angiogenesis and metastasis, is largely driven by tumor-stromal
interactions with the vasculature and the extracellular matrix (ECM). However,
there is currently a lack of understanding of the role these interactions play
in initiation and progression of the disease. In this study, we developed the
first three-dimensional, in vitro, vascularized, breast tumor platform to
quantify the spatial and temporal dynamics of tumor-vasculature and tumor-ECM
interactions specific to IBC. Platforms consisting of collagen type 1 ECM with
an endothelialized blood vessel were cultured with IBC cells, MDA-IBC3 (HER2+)
or SUM149 (triple negative), and for comparison to non-IBC cells, MDA-MB-231
(triple negative). An acellular collagen platform with an endothelial blood
vessel served as control. SUM149 and MDA-MB-231 platforms exhibited a
significantly (p<0.05) higher vessel permeability and decreased endothelial
coverage of the vessel lumen compared to the control. Both IBC platforms,
MDA-IBC3 and SUM149, expressed higher levels of VEGF (p<0.05) and increased
collagen ECM porosity compared to non-IBC MDA-MB-231 (p<0.05) and control
(p<0.01) platforms. Additionally, unique to the MDA-IBC3 platform, we observed
progressive sprouting of the endothelium over time resulting in viable vessels
with lumen. The newly sprouted vessels encircled clusters of MDA-IBC3 cells
replicating a feature of in vivo IBC. The IBC in vitro vascularized platforms
introduced in this study model well-described in vivo and clinical IBC
phenotypes and provide an adaptable, high throughout tool for systematically
and quantitatively investigating tumor-stromal mechanisms and dynamics of tumor
progression.

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The categories of this paper are: cs
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The categories of this paper are: chem-ph
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The categories of this paper are: physics
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The categories of this paper are: astro-ph
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The categories of this paper are: math
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The categories of this paper are: funct-an
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The categories of this paper are: econ
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The categories of this paper are: stat
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The categories of this paper are: cond-mat
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The categories of this paper are: acc-phys
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The categories of this paper are: comp-gas
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The categories of this paper are: nlin
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The categories of this paper are: solv-int
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The categories of this paper are: hep-lat
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The categories of this paper are: hep-th
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The categories of this paper are: hep-ex