Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Physiological underpinning of default-mode network emergence in the human infant brain Human infancy is characterized by most rapid cerebral blood flow (rCBF) increases across lifespan and emergence of a fundamental brain system default-mode network (DMN). However, how infant rCBF change spatiotemporally across the brain and how the rCBF dynamics support emergence of vital functional networks such as DMN remains unknown. Here, by acquiring cutting-edge multi-modal MRI including pseudo-continuous arterial-spin-labeled perfusion MRI and resting-state functional MRI of infants aged 0 to 24 months, we elucidated unprecedented 4D spatiotemporal infant rCBF framework and region-specific physiology-function coupling across infancy. We found faster rCBF increases in the DMN than other regions. We also found strongly coupled increases of rCBF and network strength specifically in the DMN, suggesting faster local blood flow increase to meet extra neuronal metabolic demands in the DMN maturation. These results offer insights into physiological mechanism of brain functional network emergence and have important implications in altered network maturation in brain disorders.
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The categories of this paper are: behavior
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The categories of this paper are: epidemiology
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The categories of this paper are: bioengineering
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The categories of this paper are: cognition
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The categories of this paper are: molecular
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The categories of this paper are: bioinformatics
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The categories of this paper are: biochemistry
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The categories of this paper are: genomics
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The categories of this paper are: systems
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The categories of this paper are: biophysics
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The categories of this paper are: ecology
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The categories of this paper are: and
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The categories of this paper are: pathology
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The categories of this paper are: immunology
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The categories of this paper are: education
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The categories of this paper are: developmental