Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules Cells increase microtubule dynamics to make large rearrangements to their microtubule cytoskeleton during cell division. Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to aneuploidy and cancer. Using in vitro reconstitution assays we show that the mitotic spindle protein Cytoskeleton-Associated Protein 2 (CKAP2) has a strong effect on nucleation of microtubules by lowering the critical tubulin concentration 100-fold. CKAP2 increases the apparent rate constant ka of microtubule growth by 50-fold and increases microtubule growth rates. In addition, CKAP2 strongly suppresses catastrophes. Our results identify CKAP2 as the most potent microtubule growth factor to date. These finding help explain CKAP2s role as an important spindle protein, proliferation marker, and oncogene.
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The categories of this paper are: cancer
8
The categories of this paper are: genomics
28
The categories of this paper are: communication
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The categories of this paper are: epidemiology
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The categories of this paper are: synthetic
0
The categories of this paper are: genetics
1
The categories of this paper are: bioinformatics
25
The categories of this paper are: bioengineering
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The categories of this paper are: scientific
7
The categories of this paper are: ecology
5
The categories of this paper are: cell
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The categories of this paper are: biochemistry
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The categories of this paper are: molecular
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The categories of this paper are: physiology
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The categories of this paper are: immunology
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The categories of this paper are: education