Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique when only EGI males are released. This can be facilitated by introducing conditional female-lethality to EGI strains to generate a sex-sorting incompatible male system (SSIMS). Here we demonstrate a proof of concept by combining tetracycline-controlled female lethality constructs with a pyramus-targeting EGI line in the model insect Drosophila melanogaster. We show that both functions (incompatibility and sex-sorting) are robustly maintained in the SSIMS line and that this approach is effective for population suppression in cage experiments. Further we show that SSIMS males remain competitive with wild-type males for reproduction with wild-type females, including at the level of sperm competition.
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The categories of this paper are: education
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The categories of this paper are: synthetic
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The categories of this paper are: biology
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The categories of this paper are: neuroscience
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The categories of this paper are: evolutionary
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The categories of this paper are: pharmacology
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The categories of this paper are: behavior
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The categories of this paper are: genomics
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The categories of this paper are: biochemistry
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The categories of this paper are: cognition
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The categories of this paper are: microbiology
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The categories of this paper are: molecular
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The categories of this paper are: pathology
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The categories of this paper are: animal
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The categories of this paper are: cell
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The categories of this paper are: developmental