Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Structural asymmetry along protein sequences and co-translational
  folding   Proteins are translated from the N- to the C-terminus, raising the basic
question of how this innate directionality affects their evolution. To explore
this question, we analyze 16,200 structures from the protein data bank (PDB).
We find remarkable enrichment of $\alpha$-helices at the C terminus and
$\beta$-strands at the N terminus. Furthermore, this $\alpha$-$\beta$ asymmetry
correlates with sequence length and contact order, both determinants of folding
rate, hinting at possible links to co-translational folding (CTF). Hence, we
propose the 'slowest-first' scheme, whereby protein sequences evolved
structural asymmetry to accelerate CTF: the slowest of the
cooperatively-folding segments are positioned near the N terminus so they have
more time to fold during translation. A phenomenological model predicts that
CTF can be accelerated by asymmetry, up to double the rate, when folding time
is commensurate with translation time; analysis of the PDB reveals that
structural asymmetry is indeed maximal in this regime. This correspondence is
greater in prokaryotes, which generally require faster protein production.
Altogether, this indicates that accelerating CTF is a substantial evolutionary
force whose interplay with stability and functionality is encoded in sequence
asymmetry.

4
The categories of this paper are: cond-mat
37
The categories of this paper are: supr-con
36
The categories of this paper are: cmp-lg
0
The categories of this paper are: hep-ph
2
The categories of this paper are: math
27
The categories of this paper are: comp-gas
26
The categories of this paper are: bayes-an
5
The categories of this paper are: gr-qc
11
The categories of this paper are: hep-lat
24
The categories of this paper are: dg-ga
25
The categories of this paper are: patt-sol
34
The categories of this paper are: chem-ph
31
The categories of this paper are: ao-sci
35
The categories of this paper are: mtrl-th
17
The categories of this paper are: q-fin
22
The categories of this paper are: chao-dyn