Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The motility of normal and cancer cells in response to the combined
  influence of substrate rigidity and anisotropic microstructure   Cell adhesion and migration are strongly influenced by extracellular matrix
(ECM) architecture and rigidity, but little is known about the concomitant
influence of such environmental signals to cell responses, especially when
considering cells of similar origin and morphology, but exhibiting a normal or
cancerous phenotype. Using micropatterned polydimethylsiloxane substrates
(PDMS) with tuneable stiffness (500kPa, 750kPa, 2000kPa) and topography (lines,
pillars or unpatterned), we systematically analyse the differential response of
normal (3T3) and cancer (SaI/N) fibroblastic cells. Our results demonstrate
that both cells exhibit differential morphology and motility responses to
changes in substrate rigidiy and microtopography. 3T3 polarization and
spreading are influenced by substrate microtopography and rigidity. The cells
exhibit a persistent type of migration, which depends on the substrate
anisotropy. In contrast, the dynamic of SaI/N spreading is strongly modified by
the substrate topography but not by substrate rigidity. SaI/N morphology and
migration seem to escape from extracellular cues: the cells exhibit
uncorrelated migration trajectories and a large dispersion of their migration
speed, which increases with substrate rigidity.

13
The categories of this paper are: quant-ph
25
The categories of this paper are: patt-sol
27
The categories of this paper are: comp-gas
9
The categories of this paper are: nlin
8
The categories of this paper are: hep-ex
33
The categories of this paper are: plasm-ph
35
The categories of this paper are: mtrl-th
28
The categories of this paper are: alg-geom
31
The categories of this paper are: ao-sci
5
The categories of this paper are: gr-qc
21
The categories of this paper are: adap-org
11
The categories of this paper are: hep-lat
4
The categories of this paper are: cond-mat
29
The categories of this paper are: funct-an
0
The categories of this paper are: hep-ph
16
The categories of this paper are: stat