Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Coupled effects of channels and synaptic dynamics in stochastic
  modelling of healthy and PD-affected brains   Our brain is a complex information processing network in which the nervous
system receives information from the environment to quickly react to incoming
events or learns from experience to sharp our memory. In the nervous system,
the brain states translate collective activities of neurons interconnected via
synaptic connections. In this paper, we study a model of coupled effects of
channels and synaptic dynamics in stochastic modelling of healthy brain cells
with applications to Parkinson's disease (PD). In particular, we consider a
cell membrane potential model in the thalamus part of the human brain. This
model allows us to deal with an array of coupled small-scale neural subsystems.
The subthalamic nucleus (STN) bursting phenomena and parkinsonian hypokinetic
motor symptoms are closely connected, as electrical and chemical maneuvers
modulating STN bursts are sufficient to ameliorate or mimic parkinsonian motor
deficits. One of the main factors that causes the burst discharges in STN is
adequately available calcium (Ca2+) currents. Our numerical results show that
controlling the dynamics of sodium (Na+), potassium (K+) and calcium (Ca2+)
channels together with the presences of additive and multiplicative noises in
the cell membrane potential model decreases the burst discharges in STN. These
burst discharges in STN contribute to slow the progressive loss of dopaminergic
neurons and improve motor symptoms in PD. Furthermore, we show that the
presence of noise with suitable choices of parameters in the system could delay
the burst discharges in STN.

24
The categories of this paper are: dg-ga
27
The categories of this paper are: comp-gas
28
The categories of this paper are: alg-geom
17
The categories of this paper are: q-fin
11
The categories of this paper are: hep-lat
34
The categories of this paper are: chem-ph
12
The categories of this paper are: nucl-th
14
The categories of this paper are: math-ph
26
The categories of this paper are: bayes-an
18
The categories of this paper are: econ
6
The categories of this paper are: astro-ph
4
The categories of this paper are: cond-mat
35
The categories of this paper are: mtrl-th
23
The categories of this paper are: solv-int
30
The categories of this paper are: q-alg
0
The categories of this paper are: hep-ph