Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Inferring the T-cells repertoire dynamics of healthy individuals The adaptive immune system is a diverse ecosystem that responds to pathogens by selecting cells with specific receptors. While clonal expansion in response to particular immune challenges has been extensively studied, we do not know the neutral dynamics that drive the immune system in absence of strong stimuli. Here we learn the parameters that underlie the clonal dynamics of the T-cell repertoire in healthy individuals of different ages, by applying Bayesian inference to longitudinal immune repertoire sequencing (RepSeq) data. Quantifying the experimental noise accurately for a given RepSeq technique allows us to disentangle real changes in clonal frequencies from noise. We find that the data are consistent with clone sizes following a geometric Brownian motion, and show that its predicted steady state is in quantitative agreement with the observed power-law behaviour of the clone-size distribution. The inferred turnover time scale of the repertoire increases substantially with patient age, and depends on the clone size in some individuals.
11
The categories of this paper are: cognition
25
The categories of this paper are: bioengineering
13
The categories of this paper are: animal
20
The categories of this paper are: pharmacology
10
The categories of this paper are: and
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The categories of this paper are: synthetic
0
The categories of this paper are: genetics
1
The categories of this paper are: bioinformatics
27
The categories of this paper are: pathology
15
The categories of this paper are: developmental
12
The categories of this paper are: behavior
29
The categories of this paper are: education
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The categories of this paper are: systems
30
The categories of this paper are: scientific
19
The categories of this paper are: epidemiology
7
The categories of this paper are: ecology