Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Explore synergistic and competitive miRNA regulation mechanisms in the miRNA-mRNA regulatory network from the information decomposition perspective Since multiple microRNAs can target 3 untranslated regions of the same mRNA transcript, it is likely that these endogenous microRNAs may form synergistic alliances, or compete for the same mRNA harbouring overlapping binding site matches. Synergistic and competitive microRNA regulation is an intriguing yet poorly elucidated mechanism. We here introduce a computational method based on the multivariate information measurement to quantify such implicit interaction effects between microRNAs. Our informatics method of integrating sequence and expression data is designed to establish the functional correlation between microRNAs. To demonstrate our method, we exploited TargetScan and The Cancer Genome Atlas data. As a result, we indeed observed that the microRNA pair with neighbouring binding site(s) on the mRNA is likely to trigger synergistic events, while the microRNA pair with overlapping binding site(s) on the mRNA is likely to cause competitive events, provided that the pair of microRNAs has a high functional similarity and the corresponding triplet presents a positive/negative  synergy-redundancy score.
13
The categories of this paper are: animal
8
The categories of this paper are: genomics
25
The categories of this paper are: bioengineering
4
The categories of this paper are: neuroscience
3
The categories of this paper are: evolutionary
22
The categories of this paper are: physiology
29
The categories of this paper are: education
28
The categories of this paper are: communication
26
The categories of this paper are: biochemistry
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The categories of this paper are: plant
21
The categories of this paper are: toxicology
0
The categories of this paper are: genetics
10
The categories of this paper are: and
32
The categories of this paper are: zoology
7
The categories of this paper are: ecology
2
The categories of this paper are: biology