Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Coarse-grained simulation of polymer translocation through an artificial
  nanopore   The translocation of a macromolecule through a nanometer-sized pore is an
interesting process with important applications in the development of
biosensors for single--molecule analysis and in drug delivery and gene therapy.
We have carried out a molecular dynamics simulation study of electrophoretic
translocation of a charged polymer through an artificial nanopore to explore
the feasibility of semiconductor--based nanopore devices for ultra--fast DNA
sequencing. The polymer is represented by a simple bead--spring model designed
to yield an appropriate coarse-grained description of the phosphate backbone of
DNA in salt--free aqueous solution. A detailed analysis of single translocation
event is presented to assess whether the passage of individual ions through the
pore can be detected by a nanoscale field--effect transistor by measuring
variations in electrostatic potential during polymer translocation. We find
that it is possible to identify single events corresponding to the passage of
counterions through the pore, but that discrimination of individual ions on the
polymer chain based on variations in electrostatic potential is problematic.
Several distinct stages in the translocation process are identified,
characterized by changes in polymer conformation and by variations in the
magnitude and direction of the internal electric field induced by the
fluctuating charge distribution. The dependence of the condensed fraction of
counterions on Bjerrum length leads to significant changes in polymer
conformation, which profoundly affect the dynamics of electrophoresis and
translocation.

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The categories of this paper are: solv-int
30
The categories of this paper are: q-alg
14
The categories of this paper are: math-ph
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The categories of this paper are: comp-gas
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The categories of this paper are: hep-lat
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The categories of this paper are: econ
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The categories of this paper are: bayes-an
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The categories of this paper are: cmp-lg
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The categories of this paper are: chem-ph
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The categories of this paper are: eess
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The categories of this paper are: physics
7
The categories of this paper are: hep-th
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The categories of this paper are: hep-ex
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The categories of this paper are: dg-ga
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The categories of this paper are: stat
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The categories of this paper are: acc-phys