Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: In Vitro Activity of Cysteamine Against SARS-CoV-2 Variants Global COVID-19 pandemic is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Continuous emergence of new variants and their rapid spread are jeopardizing vaccine countermeasures to a significant extent. While currently available vaccines are effective at preventing illness associated with SARS-CoV-2 infection, these have been shown to be less effective at preventing breakthrough infection and transmission from a vaccinated individual to others. Here we demonstrate broad antiviral activity of cysteamine HCl in vitro against major emergent infectious variants of SARS-CoV-2 in a highly permissible Vero cell line. Cysteamine HCl inhibited infection of wild type, alpha, beta, gamma, delta, lambda, and omicron variants effectively. Cysteamine is a very well-tolerated US FDA-approved drug used chronically as a topical ophthalmic solution to treat ocular cystinosis in patients who receive it hourly or QID lifelong at concentrations 6 to 10 times higher than that required to completely inhibit SARS CoV-2 in tissue culture. Application of cysteamine as a topical nasal treatment can potentially1) mitigate existing infection 2) prevent infection in exposed individuals, and 3) limit the contagion in vulnerable populations.
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The categories of this paper are: pathology
4
The categories of this paper are: neuroscience
2
The categories of this paper are: biology
29
The categories of this paper are: education
14
The categories of this paper are: biophysics
28
The categories of this paper are: communication
8
The categories of this paper are: genomics
23
The categories of this paper are: immunology
11
The categories of this paper are: cognition
6
The categories of this paper are: plant
32
The categories of this paper are: zoology
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The categories of this paper are: systems
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The categories of this paper are: and
21
The categories of this paper are: toxicology
19
The categories of this paper are: epidemiology
5
The categories of this paper are: cell