Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the Killifish N. furzeri The aging central nervous system (CNS) of mammals displays progressive limited regenerative abilities. Recovery after loss of neurons is extremely restricted in the aged brain. Many research models fall short in recapitulating mammalian aging hallmarks or have an impractically long lifespan. We established a traumatic brain injury model in the African turquoise killifish (Nothobranchius furzeri), a regeneration-competent vertebrate model that evolved to naturally age extremely fast. Stab-wound injury of the aged killifish dorsal telencephalon unveils an impaired and incomplete regeneration response when compared to young individuals. Remarkably, killifish brain regeneration is mainly supported by atypical non-glial progenitors, yet their proliferation capacity appears declined with age. We identified a high inflammatory response and glial scarring to also underlie the hampered generation of new neurons in aged fish. These primary results will pave the way for further research to unravel the factor age in relation to neurorepair, and to improve therapeutic strategies to restore the injured and/or diseased aged mammalian CNS.

HighlightsO_LIAging impairs neurorepair in the killifish pallium at multiple stages of the regeneration process
C_LIO_LIAtypical non-glial progenitors support the production of new neurons in the naive and injured dorsal pallium
C_LIO_LIThe impaired regeneration capacity of aged killifish is characterized by a reduced reactive proliferation of these progenitors followed by a decreased generation of newborn neurons that in addition, fail to reach the injury site
C_LIO_LIExcessive inflammation and glial scarring surface as potential brakes on brain repair in the aged killifish pallium
C_LI
7
The categories of this paper are: ecology
30
The categories of this paper are: scientific
25
The categories of this paper are: bioengineering
22
The categories of this paper are: physiology
17
The categories of this paper are: molecular
15
The categories of this paper are: developmental
21
The categories of this paper are: toxicology
26
The categories of this paper are: biochemistry
27
The categories of this paper are: pathology
6
The categories of this paper are: plant
0
The categories of this paper are: genetics
32
The categories of this paper are: zoology
29
The categories of this paper are: education
11
The categories of this paper are: cognition
9
The categories of this paper are: synthetic
2
The categories of this paper are: biology