Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Thermodynamic restrictions on evolutionary optimization of transcription
  factor proteins   Conformational fluctuations are believed to play an important role in the
process by which transcription factor proteins locate and bind their target
site on the genome of a bacterium. Using a simple model, we show that the
binding time can be minimized, under selective pressure, by adjusting the
spectrum of conformational states so that the fraction of time spent in more
mobile conformations is matched with the target recognition rate. The
associated optimal binding time is then within an order of magnitude of the
limiting binding time imposed by thermodynamics, corresponding to an idealized
protein with instant target recognition. Numerical estimates suggest that
typical bacteria operate in this regime of optimized conformational
fluctuations.

32
The categories of this paper are: atom-ph
22
The categories of this paper are: chao-dyn
26
The categories of this paper are: bayes-an
20
The categories of this paper are: acc-phys
34
The categories of this paper are: chem-ph
21
The categories of this paper are: adap-org
35
The categories of this paper are: mtrl-th
29
The categories of this paper are: funct-an
17
The categories of this paper are: q-fin
15
The categories of this paper are: nucl-ex
23
The categories of this paper are: solv-int
9
The categories of this paper are: nlin
0
The categories of this paper are: hep-ph
24
The categories of this paper are: dg-ga
19
The categories of this paper are: eess
12
The categories of this paper are: nucl-th