Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision Retinal photoreceptors differ in their transcriptomic profiles from other neuronal subtypes, likely as a reflection of their unique cellular morphology and function in the detection of light thorough the ciliary outer segment. We discovered a new layer of this molecular specialization by revealing that the vertebrate retina expresses the largest number of tissue-enriched microexons of all tissue types. A subset of these microexons is included exclusively in photoreceptor transcripts, particularly in genes involved in cilia biogenesis and in vesicle-mediated transport. This microexon program is regulated by Srrm3, a paralog of the neural microexon regulator Srrm4. Despite both proteins positively regulate retina microexons in vitro, only Srrm3 is highly expressed in mature photoreceptors and its deletion in zebrafish results in widespread downregulation of microexon inclusion, severe photoreceptor alterations and blindness. These results shed light into photoreceptors transcriptomic specialization and functionality, uncovering new cell type-specific roles for Srrm3 and microexons with implication for retinal diseases.
31
The categories of this paper are: paleontology
27
The categories of this paper are: pathology
5
The categories of this paper are: cell
22
The categories of this paper are: physiology
25
The categories of this paper are: bioengineering
15
The categories of this paper are: developmental
12
The categories of this paper are: behavior
0
The categories of this paper are: genetics
4
The categories of this paper are: neuroscience
1
The categories of this paper are: bioinformatics
16
The categories of this paper are: microbiology
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The categories of this paper are: plant
24
The categories of this paper are: cancer
20
The categories of this paper are: pharmacology
13
The categories of this paper are: animal
14
The categories of this paper are: biophysics