Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A CpG island-encoded mechanism protects genes from premature transcription termination Transcription must be highly controlled to regulate gene expression and development. However, our understanding of the molecular mechanisms that influence transcription and how these are coordinated in cells to ensure normal gene expression remains rudimentary. Here, we reveal that actively transcribed CpG island-associated gene promoters recruit SET1 chromatin modifying complexes to enable gene expression. Counterintuitively, this effect is independent of SET1 complex histone modifying activity, and instead relies on the capacity of these complexes to interact with the RNA Polymerase II-binding protein, WDR82. Unexpectedly, we discover that SET1 complexes sustain gene transcription by counteracting the activity of the ZC3H4/WDR82 protein complex, which we show can pervasively terminate both genic and extragenic transcription. Therefore, we discover a new gene regulatory mechanism whereby CpG island elements nucleate a protein complex that protects genic transcription from premature termination, effectively distinguishing genic from non-genic transcription to enable gene expression.
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The categories of this paper are: immunology
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The categories of this paper are: biochemistry
32
The categories of this paper are: zoology
27
The categories of this paper are: pathology
28
The categories of this paper are: communication
25
The categories of this paper are: bioengineering
24
The categories of this paper are: cancer
15
The categories of this paper are: developmental
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The categories of this paper are: systems
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The categories of this paper are: synthetic
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The categories of this paper are: education
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The categories of this paper are: toxicology
31
The categories of this paper are: paleontology
20
The categories of this paper are: pharmacology
4
The categories of this paper are: neuroscience
8
The categories of this paper are: genomics