Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Comprehensive analysis of the host-virus interactome of SARS-CoV-2 Host-virus protein-protein interaction is the key component of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle. We conducted a comprehensive interactome study between the virus and host cells using tandem affinity purification and proximity labeling strategies and identified 437 human proteins as the high-confidence interacting proteins. Functional characterization and further validation of these interactions elucidated how distinct SARS-CoV-2 viral proteins participate in its lifecycle, and discovered potential drug targets to the treatment of COVID-19. The interactomes of two key SARS-CoV-2 encoded viral proteins, NSP1 and N protein, were compared with the interactomes of their counterparts in other human coronaviruses. These comparisons not only revealed common host pathways these viruses manipulate for their survival, but also showed divergent protein-protein interactions that may explain differences in disease pathology. This comprehensive interactome of coronavirus disease-2019 provides valuable resources for understanding and treating this disease.
13
The categories of this paper are: animal
1
The categories of this paper are: bioinformatics
32
The categories of this paper are: zoology
14
The categories of this paper are: biophysics
30
The categories of this paper are: scientific
0
The categories of this paper are: genetics
27
The categories of this paper are: pathology
19
The categories of this paper are: epidemiology
28
The categories of this paper are: communication
26
The categories of this paper are: biochemistry
20
The categories of this paper are: pharmacology
21
The categories of this paper are: toxicology
18
The categories of this paper are: systems
16
The categories of this paper are: microbiology
9
The categories of this paper are: synthetic
15
The categories of this paper are: developmental