Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Efficient adaptive designs with mid-course sample size adjustment in
  clinical trials   Adaptive designs have been proposed for clinical trials in which the nuisance
parameters or alternative of interest are unknown or likely to be misspecified
before the trial. Whereas most previous works on adaptive designs and
mid-course sample size re-estimation have focused on two-stage or group
sequential designs in the normal case, we consider here a new approach that
involves at most three stages and is developed in the general framework of
multiparameter exponential families. Not only does this approach maintain the
prescribed type I error probability, but it also provides a simple but
asymptotically efficient sequential test whose finite-sample performance,
measured in terms of the expected sample size and power functions, is shown to
be comparable to the optimal sequential design, determined by dynamic
programming, in the simplified normal mean case with known variance and
prespecified alternative, and superior to the existing two-stage designs and
also to adaptive group sequential designs when the alternative or nuisance
parameters are unknown or misspecified.

1
The categories of this paper are: cs
27
The categories of this paper are: comp-gas
19
The categories of this paper are: eess
6
The categories of this paper are: astro-ph
22
The categories of this paper are: chao-dyn
13
The categories of this paper are: quant-ph
21
The categories of this paper are: adap-org
10
The categories of this paper are: q-bio
20
The categories of this paper are: acc-phys
37
The categories of this paper are: supr-con
36
The categories of this paper are: cmp-lg
18
The categories of this paper are: econ
0
The categories of this paper are: hep-ph
8
The categories of this paper are: hep-ex
11
The categories of this paper are: hep-lat
25
The categories of this paper are: patt-sol