Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A coupled mitral valve -- left ventricle model with fluid-structure
  interaction   Understanding the interaction between the valves and walls of the heart is
important in assessing and subsequently treating heart dysfunction. With
advancements in cardiac imaging, nonlinear mechanics and computational
techniques, it is now possible to explore the mechanics of valve-heart
interactions using anatomically and physiologically realistic models. This
study presents an integrated model of the mitral valve (MV) coupled to the left
ventricle (LV), with the geometry derived from in vivo clinical magnetic
resonance images. Numerical simulations using this coupled MV-LV model are
developed using an immersed boundary/finite element method. The model
incorporates detailed valvular features, left ventricular contraction,
nonlinear soft tissue mechanics, and fluid-mediated interactions between the MV
and LV wall. We use the model to simulate the cardiac function from diastole to
systole, and investigate how myocardial active relaxation function affects the
LV pump function. The results of the new model agree with in vivo measurements,
and demonstrate that the diastolic filling pressure increases significantly
with impaired myocardial active relaxation to maintain the normal cardiac
output. The coupled model has the potential to advance fundamental knowledge of
mechanisms underlying MV-LV interaction, and help in risk stratification and
optimization of therapies for heart diseases.

26
The categories of this paper are: bayes-an
36
The categories of this paper are: cmp-lg
14
The categories of this paper are: math-ph
25
The categories of this paper are: patt-sol
11
The categories of this paper are: hep-lat
17
The categories of this paper are: q-fin
19
The categories of this paper are: eess
2
The categories of this paper are: math
18
The categories of this paper are: econ
10
The categories of this paper are: q-bio
31
The categories of this paper are: ao-sci
30
The categories of this paper are: q-alg
28
The categories of this paper are: alg-geom
4
The categories of this paper are: cond-mat
23
The categories of this paper are: solv-int
16
The categories of this paper are: stat