Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Characterizing brain state-dependent pupil dynamics based on lateral hypothalamic activity Pupil dynamics presents varied correlation features with brain activity under different vigilant levels. The modulation of brain state changes can arise from the lateral hypothalamus (LH), where diverse neuronal cell types contribute to arousal regulation in opposite directions via the anterior cingulate cortex (ACC). However, the relationship of the LH and pupil dynamics has seldom been investigated. Here, we performed local field potential (LFP) recordings at the LH and ACC, and the whole brain fMRI with simultaneous fiber photometry Ca2+ recording in the ACC, to evaluate their correlation with brain state-dependent pupil dynamics. Both LFP and functional MRI (fMRI) data showed opposite correlation features to pupil dynamics, demonstrating an LH activity-dependent manner. Our results demonstrate that the correlation of pupil dynamics with ACC LFP and whole-brain fMRI signals depends on LH activity, indicating a role of the latter in brain state regulation.
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The categories of this paper are: pharmacology
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The categories of this paper are: animal
29
The categories of this paper are: education
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The categories of this paper are: cancer
25
The categories of this paper are: bioengineering
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The categories of this paper are: zoology
8
The categories of this paper are: genomics
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The categories of this paper are: epidemiology
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The categories of this paper are: scientific
0
The categories of this paper are: genetics
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The categories of this paper are: systems
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The categories of this paper are: evolutionary
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The categories of this paper are: cognition
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The categories of this paper are: ecology
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The categories of this paper are: microbiology
1
The categories of this paper are: bioinformatics