Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Endocrine fine-tuning of daily locomotor activity patterns under non-starving conditions in Drosophila 1.Animals need to balance competitive behaviours to maintain internal homeostasis. The underlying mechanisms are complex, but typically involve neuroendocrine signalling. Using Drosophila, we systematically manipulated signalling between energy-mobilising endocrine cells producing adipokinetic hormone (AKH), octopaminergic neurons and the energy-storing fat body to assess whether this neuroendocrine axis involved in starvation-induced hyperactivity also balances activity levels under ad libitum access to food.

Our results suggest that AKH signals via two divergent pathways that are mutually competitive in terms of activity and rest. AKH increases activity via the octopaminergic system during the day, while it prevents high activity levels during the night by signalling to the fat body. This regulation involves feedback signalling from octopaminergic neurons to AKH-producing cells (APCs). APCs are known to integrate a multitude of metabolic and endocrine signals. Our results add a new facet to the versatile regulatory functions of APCs by showing that their output contributes to shape the daily activity pattern under ad libitum access to food.
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The categories of this paper are: animal
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The categories of this paper are: developmental
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The categories of this paper are: and
24
The categories of this paper are: cancer
12
The categories of this paper are: behavior
22
The categories of this paper are: physiology
8
The categories of this paper are: genomics
29
The categories of this paper are: education
0
The categories of this paper are: genetics
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The categories of this paper are: epidemiology
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The categories of this paper are: synthetic
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The categories of this paper are: zoology
31
The categories of this paper are: paleontology
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The categories of this paper are: cell
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The categories of this paper are: toxicology
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The categories of this paper are: communication