Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Behavioural consequences of Setd1a haploinsufficiency in mice: evidence for heightened emotional reactivity and impaired sensorimotor gating A number of studies implicate the loss of function (LoF) mutations affecting the histone methyl transferase SETD1A in the aetiology of a range of neurodevelopmental disorders including schizophrenia. Here, we examined the behavioural consequences of haploinsufficiency of Setd1a in a mouse model. We find evidence for changes in a number of phenotypes of relevance to schizophrenia, including increased anxiety-related behaviour, enhanced acoustic startle response, and decreased pre-pulse inhibition of acoustic startle. The sensorimotor gating deficits in Setd1a+/- mice could not be rescued by haloperidol or risperidone, suggesting that these antipsychotics are ineffective for ameliorating schizophrenia-relevant phenotypes in Setd1a+/- mice and point to deficits in neural systems other than the monoamine system. These phenotypes are emerging as key features of a number of other mouse models of rare neurodevelopmental disorders caused by LoF mutations in genes encoding epigenome modifiers suggesting they may act in a network to modulate brain development. Taken together these data strengthen the support for the use of Setd1a haploinsufficient mice as a model for the biological basis of schizophrenia, and point towards possible underpinning neural mechanisms.
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The categories of this paper are: microbiology
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The categories of this paper are: pathology
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The categories of this paper are: paleontology
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The categories of this paper are: ecology
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The categories of this paper are: pharmacology
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The categories of this paper are: and
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The categories of this paper are: systems
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The categories of this paper are: synthetic
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The categories of this paper are: immunology
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The categories of this paper are: biophysics
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The categories of this paper are: molecular
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The categories of this paper are: bioengineering
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The categories of this paper are: communication
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The categories of this paper are: cell
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The categories of this paper are: animal
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The categories of this paper are: behavior