Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Towards Unsupervised Cancer Subtyping: Predicting Prognosis Using A
  Histologic Visual Dictionary   Unlike common cancers, such as those of the prostate and breast, tumor
grading in rare cancers is difficult and largely undefined because of small
sample sizes, the sheer volume of time needed to undertake on such a task, and
the inherent difficulty of extracting human-observed patterns. One of the most
challenging examples is intrahepatic cholangiocarcinoma (ICC), a primary liver
cancer arising from the biliary system, for which there is well-recognized
tumor heterogeneity and no grading paradigm or prognostic biomarkers. In this
paper, we propose a new unsupervised deep convolutional autoencoder-based
clustering model that groups together cellular and structural morphologies of
tumor in 246 ICC digitized whole slides, based on visual similarity. From this
visual dictionary of histologic patterns, we use the clusters as covariates to
train Cox-proportional hazard survival models. In univariate analysis, three
clusters were significantly associated with recurrence-free survival.
Combinations of these clusters were significant in multivariate analysis. In a
multivariate analysis of all clusters, five showed significance to
recurrence-free survival, however the overall model was not measured to be
significant. Finally, a pathologist assigned clinical terminology to the
significant clusters in the visual dictionary and found evidence supporting the
hypothesis that collagen-enriched fibrosis plays a role in disease severity.
These results offer insight into the future of cancer subtyping and show that
computational pathology can contribute to disease prognostication, especially
in rare cancers.

7
The categories of this paper are: hep-th
8
The categories of this paper are: hep-ex
18
The categories of this paper are: econ
31
The categories of this paper are: ao-sci
11
The categories of this paper are: hep-lat
14
The categories of this paper are: math-ph
20
The categories of this paper are: acc-phys
28
The categories of this paper are: alg-geom
27
The categories of this paper are: comp-gas
33
The categories of this paper are: plasm-ph
15
The categories of this paper are: nucl-ex
22
The categories of this paper are: chao-dyn
12
The categories of this paper are: nucl-th
0
The categories of this paper are: hep-ph
36
The categories of this paper are: cmp-lg
34
The categories of this paper are: chem-ph