Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Visualizing cancer-originated acetate uptake through MCT1 in reactive astrocytes demarcates tumor border and extends survival in glioblastoma patients Glioblastoma multiforme (GBM) is a devastating brain tumor with dismal prognosis of only 15-month survival regardless of surgical resection. Here, we report an advanced neuroimaging technique combining 11C-acetate PET and MRI (AcePET), visualizing the boundary beyond the MRI-defined tumor. Targeted biopsy of the regions with increased 11C-acetate uptake revealed the presence of reactive astrocytes with enhanced acetate-transporter MCT1, along with cancer stem cells. Reactive astrogliosis and MCT1-dependent 11C-acetate-uptake were recapitulated in U87MG-orthotopic models. Mechanistically, glycolytic tumor cells release excessive acetate causing reactive astrogliosis, leading to the release of aberrant astrocytic GABA and H2O2, which further down-regulate the neuronal glucose uptake through GLUT3. Clincally, AcePET-guided surgery allows complete tumor resection of infiltrating cancer stem cells and extends the overall survival of patients by 5.25 months compared to conventional MRI-guided surgery. We established a new concept of the metabolic interactions between GBM cells and neighboring neurons through reactive astrocytes and developed AcePET-guided surgery to fight against GBM.
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The categories of this paper are: genetics
17
The categories of this paper are: molecular
21
The categories of this paper are: toxicology
5
The categories of this paper are: cell
6
The categories of this paper are: plant
3
The categories of this paper are: evolutionary
20
The categories of this paper are: pharmacology
8
The categories of this paper are: genomics
29
The categories of this paper are: education
10
The categories of this paper are: and
19
The categories of this paper are: epidemiology
13
The categories of this paper are: animal
27
The categories of this paper are: pathology
9
The categories of this paper are: synthetic
4
The categories of this paper are: neuroscience
32
The categories of this paper are: zoology