Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Drug specific transcriptomic signatures in healthy human subject iPSC derived cardiomyocytes Drug-induced gene expression profiles are an important source for the characterization of drug-specific mechanisms of action that might also indicate potential mechanisms of drug toxicity. Unfortunately, drug-induced transcriptomic signatures are often the sum of multiple responses, such as cell line or cell-type specific responses, and can include false positive results. Both issues complicate the identification of drug-specific effects. To unmask drug-specific effects in drug-induced transcriptomic signatures, we use singular value decomposition to characterize shared transcriptomic responses induced in multiple cell lines treated with the same drug. Six different cardiomyocyte cell lines that were generated from induced pluripotent stem cells obtained from six healthy human subjects were stimulated with 25 protein kinase inhibitors, 4 monoclonal antibodies against protein kinases and 25 other cardiac- and non-cardiac acting drugs. Searching for drug-specific subspaces that characterize drug-specific responses in the original data, we could identify highly similar drug responses for multiple drugs. Pathway enrichment analysis of those responses predicts reasonable effects for multiple drugs. Revealing drug-specific responses from transcriptomic signatures might allow an easier characterization of drug-induced toxicity, such as cardiotoxic side effects induced by multiple protein kinase inhibitors and monoclonal antibodies against protein kinases.
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The categories of this paper are: animal
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The categories of this paper are: epidemiology
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The categories of this paper are: immunology
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The categories of this paper are: molecular
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The categories of this paper are: evolutionary
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The categories of this paper are: developmental
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The categories of this paper are: biochemistry
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The categories of this paper are: paleontology
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The categories of this paper are: neuroscience
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The categories of this paper are: zoology
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The categories of this paper are: and
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The categories of this paper are: pharmacology
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The categories of this paper are: biophysics
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The categories of this paper are: plant
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The categories of this paper are: bioinformatics
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The categories of this paper are: genomics