Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Requirements for efficient cell-type proportioning: regulatory
  timescales, stochasticity and lateral inhibition   The proper functioning of multicellular organisms requires the robust
establishment of precise proportions between distinct cell-types. This
developmental differentiation process typically involves intracellular
regulatory and stochastic mechanisms to generate cell-fate diversity as well as
intercellular mechanisms to coordinate cell-fate decisions at tissue level. We
thus surmise that key insights about the developmental regulation of cell-type
proportion can be captured by the modeling study of clustering dynamics in
population of inhibitory-coupled noisy bistable systems. This general class of
dynamical system is shown to exhibit a very stable two-cluster state, but also
frustrated relaxation, collective oscillations or steady-state hopping which
prevents from timely and reliably reaching a robust and well-proportioned
clustered state. To circumvent these obstacles or to avoid fine-tuning, we
highlight a general strategy based on dual-time positive feedback loops, such
as mediated through transcriptional versus epigenetic mechanisms, which
improves proportion regulation by coordinating early and flexible lineage
priming with late and firm commitment. This result sheds new light on the
respective and cooperative roles of multiple regulatory feedback, stochasticity
and lateral inhibition in developmental dynamics.

18
The categories of this paper are: econ
26
The categories of this paper are: bayes-an
7
The categories of this paper are: hep-th
17
The categories of this paper are: q-fin
20
The categories of this paper are: acc-phys
21
The categories of this paper are: adap-org
9
The categories of this paper are: nlin
6
The categories of this paper are: astro-ph
2
The categories of this paper are: math
25
The categories of this paper are: patt-sol
24
The categories of this paper are: dg-ga
0
The categories of this paper are: hep-ph
36
The categories of this paper are: cmp-lg
19
The categories of this paper are: eess
4
The categories of this paper are: cond-mat
8
The categories of this paper are: hep-ex