Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPAR signaling PLAAT3 is a phospholipid modifying enzyme predominantly expressed in white adipose tissue (WAT). It is a candidate drug target as Plaat3 deficiency in mice protects against picornavirus infection and diet-induced obesity. We identified four patients with homozygous loss-of-function mutations in PLAAT3, presenting with partial lipodystrophy, severe insulin resistance and dyslipidemia. PLAAT3-deficient WAT showed a failure to liberate arachidonic acid (AA) from membrane phospholipids resulting in an inactive gene network downstream of adipogenesis master regulator and anti-diabetic drug target PPARG. These findings establish PLAAT3 deficiency in humans as a novel type of partial lipodystrophy due to an AA- and PPARG-dependent defect in WAT differentiation and function.
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The categories of this paper are: genomics
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The categories of this paper are: zoology
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The categories of this paper are: developmental
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The categories of this paper are: evolutionary
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The categories of this paper are: toxicology
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The categories of this paper are: epidemiology
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The categories of this paper are: communication
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The categories of this paper are: cell
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The categories of this paper are: molecular
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The categories of this paper are: neuroscience
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The categories of this paper are: biochemistry
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The categories of this paper are: scientific
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The categories of this paper are: physiology
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The categories of this paper are: biophysics
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The categories of this paper are: plant
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The categories of this paper are: animal