Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, NVX-CoV2373) cross-recognize SARS-CoV-2 variants. Preservation of at least 83% and 85% for CD4+ and CD8+ T cell responses was found, respectively, regardless of vaccine platform or variants analyzed. By contrast, highly significant decreases were observed for memory B cell and neutralizing antibody recognition of variants. Bioinformatic analyses showed full conservation of 91% and 94% of class II and class I spike epitopes. For Omicron, 72% of class II and 86% of class I epitopes were fully conserved, and 84% and 85% of CD4+ and CD8+ T cell responses were preserved. In-depth epitope repertoire analysis showed a median of 11 and 10 spike epitopes recognized by CD4+ and CD8+ T cells from vaccinees. Functional preservation of the majority of the T cell responses may play an important role as a second-level defense against diverse variants.
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The categories of this paper are: pathology
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The categories of this paper are: biochemistry
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The categories of this paper are: cancer
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The categories of this paper are: pharmacology
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The categories of this paper are: biology
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The categories of this paper are: and
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The categories of this paper are: behavior
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The categories of this paper are: bioinformatics
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The categories of this paper are: biophysics
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The categories of this paper are: physiology
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The categories of this paper are: molecular
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The categories of this paper are: microbiology
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The categories of this paper are: education
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The categories of this paper are: animal
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The categories of this paper are: scientific
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The categories of this paper are: bioengineering