Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations Chromosomal translocations result from the joining of DNA double-strand breaks (DSBs) and frequently cause cancer. Yet, the steps linking DSB formation to DSB ligation remain undeciphered. We report that DNA replication timing (RT), mediated by replication origin activity, directly regulates the genesis of lymphomagenic Myc translocations during antibody maturation in B cells. Reduced levels of the replicative helicase, the minichromosome-maintenance (MCM) complex, decreases translocations and globally abrogates the RT program. Ablating a single replication origin at Myc causes an early-to-late RT switch with major loss of translocations, a phenotype that is reversed by restoring early RT. Finally, this novel RT-regulated mechanism occurs after DSB formation and independently of DSB frequency. Thus, RT constitutes a distinct regulatory event in translocation biogenesis linking DSB formation to DSB ligation.
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The categories of this paper are: immunology
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The categories of this paper are: toxicology
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The categories of this paper are: synthetic
31
The categories of this paper are: paleontology
12
The categories of this paper are: behavior
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The categories of this paper are: biochemistry
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The categories of this paper are: biophysics
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The categories of this paper are: neuroscience
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The categories of this paper are: systems
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The categories of this paper are: developmental
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The categories of this paper are: pharmacology
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The categories of this paper are: bioengineering
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The categories of this paper are: zoology
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The categories of this paper are: animal
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The categories of this paper are: and
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The categories of this paper are: cognition