Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Big Pharma, little science? A bibliometric perspective on big pharma's
  R&D decline   There is a widespread perception that pharmaceutical R&D is facing a
productivity crisis characterised by stagnation in the numbers of new drug
approvals in the face of increasing R&D costs. This study explores
pharmaceutical R&D dynamics by examining the publication activities of all R&D
laboratories of the major European and US pharmaceutical firms during the
period 1995-2009. The empirical findings present an industry in
transformation.In the first place, we observe a decline of the total number of
publications by large firms. Second, we show a relative increase of their
external collaborations suggesting a tendency to outsource, and a
diversification of the disciplinary base, in particular towards computation,
health services and more clinical approaches. Also evident is a more pronounced
decline in publications by both R&D laboratories located in Europe and by firms
with European headquarters. Finally, while publications by Big Pharma in
emerging economies sharply increase, they remain extremely low compared with
those in developed countries. In summary, the trend in this transformation is
one of a gradual decrease in internal research efforts and increasing reliance
on external research. These empirical insights support the view that large
pharmaceutical firms are increasingly becoming networks integrators rather than
the prime locus of drug discovery.

27
The categories of this paper are: comp-gas
23
The categories of this paper are: solv-int
37
The categories of this paper are: supr-con
32
The categories of this paper are: atom-ph
30
The categories of this paper are: q-alg
34
The categories of this paper are: chem-ph
35
The categories of this paper are: mtrl-th
28
The categories of this paper are: alg-geom
26
The categories of this paper are: bayes-an
8
The categories of this paper are: hep-ex
10
The categories of this paper are: q-bio
4
The categories of this paper are: cond-mat
20
The categories of this paper are: acc-phys
12
The categories of this paper are: nucl-th
2
The categories of this paper are: math
13
The categories of this paper are: quant-ph