Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Investigations of the Underlying Mechanisms of HIF-1{\alpha} and CITED2
  Binding to TAZ1   The TAZ1 domain of CREB binding protein is crucial for transcriptional
regulation and recognizes multiple targets. The interactions between TAZ1 and
its specific targets are related to the cellular hypoxic negative feedback
regulation. Previous experiments reported that one of the TAZ1 targets CITED2
is an efficient competitor of another target HIF-1{\alpha}. Here by developing
the structure-based models of TAZ1 complexes we have uncovered the underlying
mechanisms of the competitions between HIF-1{\alpha} and CITED2 binding to
TAZ1. Our results are consistent with the experimental hypothesis on the
competition mechanisms and the apparent affinity. In addition, the simulations
prove the dominant position of forming TAZ1-CITED2 complex in both
thermodynamics and kinetics. For thermodynamics, TAZ1-CITED2 is the lowest
basin located on the free energy surface of binding in the ternary system. For
kinetics, the results suggest that CITED2 binds to TAZ1 faster than
HIF-1{\alpha}. Besides, the analysis of contact map and f values in this study
will be helpful for further experiments on TAZ1 systems.

17
The categories of this paper are: q-fin
26
The categories of this paper are: bayes-an
30
The categories of this paper are: q-alg
36
The categories of this paper are: cmp-lg
6
The categories of this paper are: astro-ph
5
The categories of this paper are: gr-qc
34
The categories of this paper are: chem-ph
31
The categories of this paper are: ao-sci
4
The categories of this paper are: cond-mat
16
The categories of this paper are: stat
24
The categories of this paper are: dg-ga
25
The categories of this paper are: patt-sol
32
The categories of this paper are: atom-ph
7
The categories of this paper are: hep-th
11
The categories of this paper are: hep-lat
9
The categories of this paper are: nlin