Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Genomic inference of a human super bottleneck in the Early Stone Age The demographic history is a foundation of human evolutionary studies. However, the ancient demographic history during the Mid-Pleistocene is poorly investigated while it is essential for understanding the early origin of humankind. Here we present the fast infinitesimal time coalescent (FitCoal) process, which allows the analytical calculation of the composite likelihood of a site frequency spectrum and provides the precise inference of demographic history. We apply it to analyze 3,154 present-day human genomic sequences. We find that African populations have passed through a population super bottleneck, a small effective size of approximately 1,280 breeding individuals between 930 and 813 thousand years ago. Further analyses confirm the existence of the super bottleneck on non-African populations although it cannot be directly inferred. This observation, together with simulation results, indicates that confounding factors, such as population structure and selection, are unlikely to affect the inference of the super bottleneck. The time interval of the super bottleneck coincides with a gap in the human fossil record in Africa and possibly marks the origin of Homo heidelbergensis. Our results provide new insights into human evolution during the Mid-Pleistocene.
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The categories of this paper are: scientific
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The categories of this paper are: physiology
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The categories of this paper are: cognition
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The categories of this paper are: molecular
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The categories of this paper are: toxicology
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The categories of this paper are: bioengineering
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The categories of this paper are: paleontology
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The categories of this paper are: epidemiology
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The categories of this paper are: and
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The categories of this paper are: systems
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The categories of this paper are: pharmacology
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The categories of this paper are: behavior
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The categories of this paper are: neuroscience
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The categories of this paper are: cell
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The categories of this paper are: communication
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The categories of this paper are: plant