Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Connecting the dots across time: Reconstruction of single cell signaling
  trajectories using time-stamped data   Single cell responses are shaped by the geometry of signaling kinetic
trajectories carved in a multidimensional space spanned by signaling protein
abundances. It is however challenging to assay large number (>3) of signaling
species in live-cell imaging which makes it difficult to probe single cell
signaling kinetic trajectories in large dimensions. Flow and mass cytometry
techniques can measure a large number (4 - >40) of signaling species but are
unable to track single cells. Thus cytometry experiments provide detailed time
stamped snapshots of single cell signaling kinetics. Is it possible to use the
time stamped cytometry data to reconstruct single cell signaling trajectories?
Borrowing concepts of conserved and slow variables from non-equilibrium
statistical physics we develop an approach to reconstruct signaling
trajectories using snapshot data by creating new variables that remain
invariant or vary slowly during the signaling kinetics. We apply this approach
to reconstruct trajectories using snapshot data obtained from in silico
simulations and live-cell imaging measurements. The use of invariants and slow
variables to reconstruct trajectories provides a radically different way to
track object using snapshot data. The approach is likely to have implications
for solving matching problems in a wide range of disciplines.

6
The categories of this paper are: astro-ph
5
The categories of this paper are: gr-qc
7
The categories of this paper are: hep-th
2
The categories of this paper are: math
25
The categories of this paper are: patt-sol
29
The categories of this paper are: funct-an
37
The categories of this paper are: supr-con
3
The categories of this paper are: physics
32
The categories of this paper are: atom-ph
33
The categories of this paper are: plasm-ph
22
The categories of this paper are: chao-dyn
34
The categories of this paper are: chem-ph
0
The categories of this paper are: hep-ph
18
The categories of this paper are: econ
9
The categories of this paper are: nlin
27
The categories of this paper are: comp-gas