Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The competitive nature of STAT complex formation drives phenotype
  switching of T cells   Signal transducers and activators of transcription (STATs) are key molecular
determinants of T cell fate and effector function. A number of inflammatory
diseases are characterized by an altered balance of T cell phenotypes and
cytokine secretion. STATs, therefore, represent viable therapeutic targets in
numerous pathologies. However, the underlying mechanisms of how the same STAT
proteins regulate both the development of different T cell phenotypes and their
plasticity during changes in extracellular conditions remain unclear. In this
study, we investigated the STAT mediated regulation of T cell phenotype
formation and plasticity using mathematical modeling and experimental data for
intracellular STAT signaling proteins. The close fit of our model predictions
to the experimental data for IFN-{\gamma} to IL-10 switching allows us to
propose a potential mechanism for T cell switching that regulates human Th1/Tr1
responses. According to this mechanism, T cell phenotype switching is due to
the relative redistribution of STAT dimer complexes caused by the extracellular
cytokine-dependent STAT competition effects. The proposed model is applicable
to a number of STAT signaling circuits.

31
The categories of this paper are: ao-sci
11
The categories of this paper are: hep-lat
12
The categories of this paper are: nucl-th
19
The categories of this paper are: eess
23
The categories of this paper are: solv-int
15
The categories of this paper are: nucl-ex
5
The categories of this paper are: gr-qc
24
The categories of this paper are: dg-ga
26
The categories of this paper are: bayes-an
4
The categories of this paper are: cond-mat
33
The categories of this paper are: plasm-ph
17
The categories of this paper are: q-fin
22
The categories of this paper are: chao-dyn
20
The categories of this paper are: acc-phys
13
The categories of this paper are: quant-ph
32
The categories of this paper are: atom-ph