Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Truncated Rank-Based Tests for Two-Part Models with Excessive Zeros and
  Applications to Microbiome Data   High-throughput sequencing technology allows us to test the compositional
difference of bacteria in different populations. One important feature of human
microbiome data is that it often includes a large number of zeros. Such data
can be treated as being generated from a two-part model that includes a zero
point-mass. Motivated by analysis of such non-negative data with excessive
zeros, we introduce several truncated rank-based two-group and multi-group
tests for such data, including a truncated rank-based Wilcoxon rank-sum test
for two-group comparison and two truncated Kruskal-Wallis tests for multi-group
comparison. We show both analytically through asymptotic relative efficiency
analysis and by simulations that the proposed tests have higher power than the
standard rank-based tests, especially when the proportion of zeros in the data
is high. The tests can also be applied to repeated measurements of
compositional data via simple within-subject permutations. We apply the tests
to the analysis of a gut microbiome data set to compare the microbiome
compositions of healthy and pediatric Crohn's disease patients and to assess
the treatment effects on microbiome compositions. We identify several bacterial
genera that are missed by the standard rank-based tests.

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The categories of this paper are: nlin
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The categories of this paper are: q-alg
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The categories of this paper are: hep-ex
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The categories of this paper are: nucl-ex
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The categories of this paper are: supr-con
34
The categories of this paper are: chem-ph
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The categories of this paper are: acc-phys
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The categories of this paper are: math
0
The categories of this paper are: hep-ph
25
The categories of this paper are: patt-sol
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The categories of this paper are: comp-gas
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The categories of this paper are: solv-int
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The categories of this paper are: adap-org
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The categories of this paper are: mtrl-th
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The categories of this paper are: physics
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The categories of this paper are: math-ph