Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis PTEN is a potent tumor suppressor gene that is frequently mutated or deleted in human cancers. Such deletions often include portions of the 10q23 locus beyond the bounds of PTEN itself, in many cases resulting in the disruption of additional genes. Coincidental loss of PTEN-adjacent genes might impose vulnerabilities that could either affect patient outcome basally or be exploited therapeutically. Here we describe how the loss of ATAD1, which is adjacent to and frequently co-deleted with PTEN, predisposes cancer cells to apoptosis and correlates with improved survival in cancer patients. ATAD1 directly and specifically extracts the pro-apoptotic BIM protein from mitochondria to inactivate it. Cells lacking ATAD1 are hypersensitive to clinically used proteasome inhibitors, which increase BIM and trigger apoptosis. Thus, we demonstrate that mitochondrial protein quality control interfaces with cell death in a clinically actionable manner.
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The categories of this paper are: ecology
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The categories of this paper are: pathology
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The categories of this paper are: microbiology
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The categories of this paper are: education
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The categories of this paper are: toxicology
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The categories of this paper are: biochemistry
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The categories of this paper are: pharmacology
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The categories of this paper are: molecular
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The categories of this paper are: bioengineering
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The categories of this paper are: paleontology
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The categories of this paper are: behavior
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The categories of this paper are: neuroscience
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The categories of this paper are: immunology
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The categories of this paper are: systems
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The categories of this paper are: epidemiology
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The categories of this paper are: physiology