Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Suppression of transposon mobilization by m6A-mediated RNA sequestration in stress granules Transposon is a mobile and ubiquitous DNA that can vastly causes genomic alterations. In plants, it is well documented that transposon mobilization is strongly repressed by DNA methylation; however, the roles of RNA methylation in transposon control remain unknown. Here we suggest that transposon RNA is marked by m6A RNA methylation and is sequestered in stress granule (SG) in m6A-dependent manner. Intriguingly, a SG-localized AtALKBH9B selectively demethylates a heat-activated retroelement Onsen, and thereby releases from spatial confinement allowing for its mobilization. In addition, we show evidence that m6A RNA methylation contributes to transpositional suppression by inhibiting the virus-like particles assembly and extrachromosomal DNA production. In summary, this study unveils a hidden role for m6A in the suppression of transposon mobility and provides an insight into how transposon counteracts the hosts epitranscriptomic control by hitchhiking RNA demethylase.
15
The categories of this paper are: developmental
0
The categories of this paper are: genetics
30
The categories of this paper are: scientific
8
The categories of this paper are: genomics
9
The categories of this paper are: synthetic
11
The categories of this paper are: cognition
19
The categories of this paper are: epidemiology
25
The categories of this paper are: bioengineering
1
The categories of this paper are: bioinformatics
31
The categories of this paper are: paleontology
5
The categories of this paper are: cell
17
The categories of this paper are: molecular
20
The categories of this paper are: pharmacology
24
The categories of this paper are: cancer
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The categories of this paper are: and
4
The categories of this paper are: neuroscience