Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Slowing of Frontocentral Beta Oscillations in Atypical Parkinsonism Diagnosis of atypical parkinsonian syndromes mostly relies on clinical presentation as well as structural and molecular brain imaging. It has not been investigated whether cortical oscillatory activity exhibits features distinguishing these syndromes. Therefore, we measured resting-state magnetoencephalography in 13 patients with corticobasal syndrome, 10 patients with progressive supranuclear palsy, 23 patients with idiopathic Parkinsons disease and 23 healthy controls. We compared spectral power as well as amplitude and frequency of power peaks between the groups.

Atypical Parkinsonism was associated with spectral slowing, distinguishing both corticobasal syndrome and progressive supranuclear palsy from age-matched healthy controls and Parkinsons disease. Patients with atypical Parkinsonism showed a shift of beta peaks (13-30 Hz) towards lower frequencies in frontal and central areas bilaterally. A concomitant increase in theta/alpha power relative to controls was observed in both atypical parkinsonian syndromes and in Parkinsons disease.

Our results demonstrate that slowing of frontocentral beta oscillations is characteristic of atypical Parkinsonism. Spectral slowing with a different topography has previously been observed in other neurodegenerative disorders, such as Alzheimers disease, suggesting that spectral slowing might be an electrophysiological marker of cortical neurodegeneration. As such, it might support differential diagnosis of parkinsonian syndromes in the future.

HighlightsO_LISlowing of beta oscillations distinguishes atypical parkinsonian syndromes from healthy controls and idiopathic Parkinsons disease
C_LIO_LISpectral slowing is most pronounced in frontocentral areas
C_LIO_LIBeta oscillations are shifted towards lower frequencies independent of their amplitude
C_LI
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The categories of this paper are: ecology
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The categories of this paper are: genomics
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The categories of this paper are: scientific
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The categories of this paper are: immunology
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The categories of this paper are: synthetic
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The categories of this paper are: cancer
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The categories of this paper are: toxicology
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The categories of this paper are: plant
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The categories of this paper are: pathology
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The categories of this paper are: paleontology
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The categories of this paper are: developmental
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The categories of this paper are: bioengineering
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The categories of this paper are: microbiology
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The categories of this paper are: cognition
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The categories of this paper are: genetics
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The categories of this paper are: systems