Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: SANTIAGO: Spine Association for Neuron Topology Improvement and Graph
  Optimization   Developing automated and semi-automated solutions for reconstructing wiring
diagrams of the brain from electron micrographs is important for advancing the
field of connectomics. While the ultimate goal is to generate a graph of neuron
connectivity, most prior automated methods have focused on volume segmentation
rather than explicit graph estimation. In these approaches, one of the key,
commonly occurring error modes is dendritic shaft-spine fragmentation.
  We posit that directly addressing this problem of connection identification
may provide critical insight into estimating more accurate brain graphs. To
this end, we develop a network-centric approach motivated by biological priors
image grammars. We build a computer vision pipeline to reconnect fragmented
spines to their parent dendrites using both fully-automated and semi-automated
approaches. Our experiments show we can learn valid connections despite
uncertain segmentation paths. We curate the first known reference dataset for
analyzing the performance of various spine-shaft algorithms and demonstrate
promising results that recover many previously lost connections. Our automated
approach improves the local subgraph score by more than four times and the full
graph score by 60 percent. These data, results, and evaluation tools are all
available to the broader scientific community. This reframing of the
connectomics problem illustrates a semantic, biologically inspired solution to
remedy a major problem with neuron tracking.

3
The categories of this paper are: physics
30
The categories of this paper are: q-alg
35
The categories of this paper are: mtrl-th
21
The categories of this paper are: adap-org
18
The categories of this paper are: econ
25
The categories of this paper are: patt-sol
2
The categories of this paper are: math
0
The categories of this paper are: hep-ph
11
The categories of this paper are: hep-lat
6
The categories of this paper are: astro-ph
19
The categories of this paper are: eess
16
The categories of this paper are: stat
37
The categories of this paper are: supr-con
24
The categories of this paper are: dg-ga
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The categories of this paper are: nucl-th
36
The categories of this paper are: cmp-lg