Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Integrative genetic risk prediction using nonparametric empirical Bayes
  classification   Genetic risk prediction is an important component of individualized medicine,
but prediction accuracies remain low for many complex diseases. A fundamental
limitation is the sample sizes of the studies on which the prediction
algorithms are trained. One way to increase the effective sample size is to
integrate information from previously existing studies. However, it can be
difficult to find existing data that examine the target disease of interest,
especially if that disease is rare or poorly studied. Furthermore,
individual-level genotype data from these auxiliary studies are typically
difficult to obtain. This paper proposes a new approach to integrative genetic
risk prediction of complex diseases with binary phenotypes. It accommodates
possible heterogeneity in the genetic etiologies of the target and auxiliary
diseases using a tuning parameter-free nonparametric empirical Bayes procedure,
and can be trained using only auxiliary summary statistics. Simulation studies
show that the proposed method can provide superior predictive accuracy relative
to non-integrative as well as integrative classifiers. The method is applied to
a recent study of pediatric autoimmune diseases, where it substantially reduces
prediction error for certain target/auxiliary disease combinations. The
proposed method is implemented in the R package ssa.

15
The categories of this paper are: nucl-ex
26
The categories of this paper are: bayes-an
3
The categories of this paper are: physics
14
The categories of this paper are: math-ph
8
The categories of this paper are: hep-ex
37
The categories of this paper are: supr-con
1
The categories of this paper are: cs
21
The categories of this paper are: adap-org
9
The categories of this paper are: nlin
27
The categories of this paper are: comp-gas
23
The categories of this paper are: solv-int
36
The categories of this paper are: cmp-lg
11
The categories of this paper are: hep-lat
18
The categories of this paper are: econ
29
The categories of this paper are: funct-an
22
The categories of this paper are: chao-dyn