Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A biomathematical model of tumor response to radioimmunotherapy with
  $\alpha$PDL1 and $\alpha$CTLA4   There is evidence of synergy between radiotherapy and immunotherapy.
Radiotherapy can increase liberation of tumor antigens, causing activation of
antitumor T-cells. This effect can be boosted with immunotherapy.
Radioimmunotherapy has potential to increase tumor control rates.
Biomathematical models of response to radioimmunotherapy may help on the
understanding of the mechanisms affecting response, and assist clinicians on
the design of optimal treatment strategies. In this work we present a
biomathematical model of tumor response to radioimmunotherapy. The model uses
the linear-quadratic response of tumor cells to radiation (or variation of it),
and builds on previous developments to include the radiation-induced immune
effect. We have focused this study on the combined effect of radiotherapy and
$\alpha$PDL1/$\alpha$CTLA4 therapies. The model fits recent preclinical data of
volume dynamics and control obtained with different dose fractionations and
$\alpha$PDL1/$\alpha$CTLA4. A biomathematical study of optimal combination
strategies suggests that a good understanding of the biological delays
associated to radoimmunotherapy, the biokinetics of the immunotherapy drug, and
the interplay between them, may be of paramount importance to design optimal
radioimmunotherapy schedules. Biomathematical models like the one we present
can help to interpret experimental data on the synergy between radiotherapy and
immunotherapy, and to assist in the design of more effective treatments.

20
The categories of this paper are: acc-phys
16
The categories of this paper are: stat
9
The categories of this paper are: nlin
35
The categories of this paper are: mtrl-th
30
The categories of this paper are: q-alg
2
The categories of this paper are: math
1
The categories of this paper are: cs
28
The categories of this paper are: alg-geom
34
The categories of this paper are: chem-ph
22
The categories of this paper are: chao-dyn
21
The categories of this paper are: adap-org
14
The categories of this paper are: math-ph
10
The categories of this paper are: q-bio
12
The categories of this paper are: nucl-th
15
The categories of this paper are: nucl-ex
8
The categories of this paper are: hep-ex