Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Cell-cell communication enhances the capacity of cell ensembles to sense
  shallow gradients during morphogenesis   Collective cell responses to exogenous cues depend on cell-cell interactions.
In principle, these can result in enhanced sensitivity to weak and noisy
stimuli. However, this has not yet been shown experimentally, and, little is
known about how multicellular signal processing modulates single cell
sensitivity to extracellular signaling inputs, including those guiding complex
changes in the tissue form and function. Here we explored if cell-cell
communication can enhance the ability of cell ensembles to sense and respond to
weak gradients of chemotactic cues. Using a combination of experiments with
mammary epithelial cells and mathematical modeling, we find that multicellular
sensing enables detection of and response to shallow Epidermal Growth Factor
(EGF) gradients that are undetectable by single cells. However, the advantage
of this type of gradient sensing is limited by the noisiness of the signaling
relay, necessary to integrate spatially distributed ligand concentration
information. We calculate the fundamental sensory limits imposed by this
communication noise and combine them with the experimental data to estimate the
effective size of multicellular sensory groups involved in gradient sensing.
Functional experiments strongly implicated intercellular communication through
gap junctions and calcium release from intracellular stores as mediators of
collective gradient sensing. The resulting integrative analysis provides a
framework for understanding the advantages and limitations of sensory
information processing by relays of chemically coupled cells.

17
The categories of this paper are: q-fin
4
The categories of this paper are: cond-mat
29
The categories of this paper are: funct-an
24
The categories of this paper are: dg-ga
36
The categories of this paper are: cmp-lg
37
The categories of this paper are: supr-con
30
The categories of this paper are: q-alg
0
The categories of this paper are: hep-ph
26
The categories of this paper are: bayes-an
27
The categories of this paper are: comp-gas
31
The categories of this paper are: ao-sci
13
The categories of this paper are: quant-ph
34
The categories of this paper are: chem-ph
7
The categories of this paper are: hep-th
19
The categories of this paper are: eess
33
The categories of this paper are: plasm-ph