Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Lysophosphatidylcholine induces heat pain hypersensitivity in obese mice fed with a high-fat diet through activation of peripheral Acid-Sensing Ion Channel 3 Diet induced obesity is one of the major causes of obesity, which affects 13% of the worlds adult population. Obesity is correlated to chronic pain regardless of other components of the metabolic syndrome. Our study focuses on investigating the effect of high-fat diet induced obesity on peripheral sensory neurons activity and pain perception, followed by deciphering the underlying cellular and molecular mechanisms that involve Acid-Sensing Ion Channel 3 (ASIC3). We show here that heat sensitive C-fibers from mice made obese by consumption of a high-fat diet exhibited an increased activity during baseline and upon heating. Obese mice showed long-lasting heat pain hypersensitivity once obesity was well established, while mechanical sensitivity was not affected. We found that the serum of obese mice was enriched in lysophosphatidylcholine (LPC) species (LPC16:0, LPC18:0 and LPC18:1), which activate ASIC3 channels and increased peripheral neuron excitability. Genetic deletion and in vivo pharmacological inhibition of ASIC3 protected and rescued mice from obesity-induced thermal hypersensitivity. Our results identify ASIC3 channels in DRG neurons and circulating LPC species that activate them as a mechanism contributing to heat pain hypersensitivity associated with high-fat diet induced obesity.
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The categories of this paper are: education
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The categories of this paper are: systems
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The categories of this paper are: cancer
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The categories of this paper are: bioengineering
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The categories of this paper are: molecular
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The categories of this paper are: pathology
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The categories of this paper are: developmental
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The categories of this paper are: epidemiology
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The categories of this paper are: bioinformatics
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The categories of this paper are: immunology
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The categories of this paper are: biochemistry
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The categories of this paper are: genetics
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The categories of this paper are: synthetic
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The categories of this paper are: behavior
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The categories of this paper are: animal
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The categories of this paper are: ecology