Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice Astrocyte-derived cholesterol supports brain cells under physiological conditions. However, in demyelinating lesions, astrocytes downregulate cholesterol synthesis and the cholesterol that is essential for remyelination has to originate from other cellular sources. Here, we show that repair following acute versus chronic demyelination involves distinct processes. In particular, we found that in chronic myelin disease, when recycling of lipids is often defective, de novo neuronal cholesterol synthesis is critical for regeneration. By gene expression profiling, genetic loss of function experiments and comprehensive phenotyping, we provide evidence that neurons increase cholesterol synthesis in chronic myelin disease models and MS patients. In mouse models, neuronal cholesterol facilitated remyelination specifically by triggering OPC proliferation. Our data contribute to the understanding of disease progression and have implications for therapeutic strategies in MS patients.
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The categories of this paper are: cancer
30
The categories of this paper are: scientific
21
The categories of this paper are: toxicology
25
The categories of this paper are: bioengineering
10
The categories of this paper are: and
23
The categories of this paper are: immunology
6
The categories of this paper are: plant
16
The categories of this paper are: microbiology
32
The categories of this paper are: zoology
22
The categories of this paper are: physiology
1
The categories of this paper are: bioinformatics
13
The categories of this paper are: animal
27
The categories of this paper are: pathology
8
The categories of this paper are: genomics
0
The categories of this paper are: genetics
31
The categories of this paper are: paleontology