Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A pharmacokinetic -- viral kinetic model describes the effect of
  alisporivir monotherapy or in combination with peg-IFN on 2 hepatitis C
  virologic response   Alisporivir is a cyclophilin inhibitor with demonstrated in vitro and in vivo
activity against hepatitis C 11 virus (HCV). We estimated antiviral
effectiveness of alisporivir alone or in combination with 12
pegylated-Inteferon (peg-IFN) in 88 patients infected with different HCV
genotypes treated for four 13 weeks. The pharmacokinetics of both drugs were
modeled and used as driving functions for the viral 14 kinetic model. Genotype
was found to significantly affect pegylated-Inteferon effectiveness
($\epsilon$= 86.3% 15 and 99.1% in genotype-1/4 and genotype-2/3, respectively,
p\textless{}10 -7) and infected cells loss rate ($\delta$= 16 0.22 vs 0.39 day
-1 in genotype-1/4 and genotype-2/3, respectively, p\textless{}10 -6).
Alisporivir effectiveness 17 was not significantly different across genotype
and was high for doses $\ge$600 mg QD. We simulated 18 virologic responses with
other alisporivir dosing regimens in HCV genotype-2/3 patients using the 19
model. Our predictions consistently matched the observed responses,
demonstrating that this model 20 could be a useful tool for anticipating
virologic response and optimize alisporivir-based therapies.

7
The categories of this paper are: hep-th
28
The categories of this paper are: alg-geom
22
The categories of this paper are: chao-dyn
31
The categories of this paper are: ao-sci
34
The categories of this paper are: chem-ph
2
The categories of this paper are: math
26
The categories of this paper are: bayes-an
6
The categories of this paper are: astro-ph
1
The categories of this paper are: cs
20
The categories of this paper are: acc-phys
3
The categories of this paper are: physics
32
The categories of this paper are: atom-ph
29
The categories of this paper are: funct-an
24
The categories of this paper are: dg-ga
25
The categories of this paper are: patt-sol
36
The categories of this paper are: cmp-lg