Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Improving Baseline Subtraction for Increased Sensitivity of Quantitative
  PCR Measurements   Motivated by the current COVID-19 health-crisis, we examine the task of
baseline subtraction for quantitative polymerase chain-reaction (qPCR)
measurements. In particular, we present an algorithm that leverages information
obtained from non-template and/or DNA extraction-control experiments to remove
systematic bias from amplification curves. We recast this problem in terms of
mathematical optimization, i.e. by finding the amount of control signal that,
when subtracted from an amplification curve, minimizes background noise. We
demonstrate that this approach can yield a decade improvement in sensitivity
relative to standard approaches, especially for data exhibiting late-cycle
amplification. Critically, this increased sensitivity and accuracy promises
more effective screening of viral DNA and a reduction in the rate of
false-negatives in diagnostic settings.

7
The categories of this paper are: hep-th
36
The categories of this paper are: cmp-lg
15
The categories of this paper are: nucl-ex
35
The categories of this paper are: mtrl-th
33
The categories of this paper are: plasm-ph
23
The categories of this paper are: solv-int
0
The categories of this paper are: hep-ph
9
The categories of this paper are: nlin
11
The categories of this paper are: hep-lat
31
The categories of this paper are: ao-sci
22
The categories of this paper are: chao-dyn
32
The categories of this paper are: atom-ph
20
The categories of this paper are: acc-phys
29
The categories of this paper are: funct-an
24
The categories of this paper are: dg-ga
8
The categories of this paper are: hep-ex