Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Dynein catch bond as a mediator of codependent bidirectional cellular
  transport   Intracellular bidirectional transport of cargo on microtubule filaments is
achieved by the collective action of oppositely directed dynein and kinesin
motors. Experiments have found that in certain cases, inhibiting the activity
of one type of motor results in an overall decline in the motility of the
cellular cargo in both directions. This counter-intuitive observation, referred
to as {\em paradox of codependence} is inconsistent with the existing paradigm
of a mechanistic tug-of-war between oppositely directed motors. Unlike kinesin,
dynein motors exhibit catchbonding, wherein the unbinding rates of these motors
decrease with increasing force on them. Incorporating this catchbonding
behavior of dynein in a theoretical model, we show that the functional
divergence of the two motors species manifests itself as an internal regulatory
mechanism, and leads to codependent transport behaviour in biologically
relevant regimes. Using analytical methods and stochastic simulations, we
analyse the processivity characteristics and probability distribution of run
times and pause times of transported cellular cargoes. We show that
catchbonding can drastically alter the transport characteristics and also
provide a plausible resolution of the paradox of codependence.

7
The categories of this paper are: hep-th
37
The categories of this paper are: supr-con
32
The categories of this paper are: atom-ph
16
The categories of this paper are: stat
33
The categories of this paper are: plasm-ph
18
The categories of this paper are: econ
26
The categories of this paper are: bayes-an
11
The categories of this paper are: hep-lat
22
The categories of this paper are: chao-dyn
24
The categories of this paper are: dg-ga
4
The categories of this paper are: cond-mat
28
The categories of this paper are: alg-geom
30
The categories of this paper are: q-alg
5
The categories of this paper are: gr-qc
23
The categories of this paper are: solv-int
31
The categories of this paper are: ao-sci