Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: HybridRanker: Integrating network structure and disease knowledge to
  prioritize cancer candidate genes   One of the notable fields in studying the genetics of cancer is disease gene
identification which affects disease treatment and drug discovery. Many
researches have been done in this field. Genome-wide association studies (GWAS)
are one of them that focus on the identification of diseases-susceptible loci
on chromosomes. Recently, computational approaches, known as gene
prioritization methods have been used to identify candidate disease genes. Gene
prioritization methods integrate several data sources to discover and
prioritize the most probable candidate disease genes. In this paper, we propose
a prioritization method, called HybridRanker which is a network-based technique
and it also uses experimental data to identify candidate cancer genes. We apply
our proposed method on colorectal cancer data. It is notable to say that in
HybridRanker, for considering both local and global network information of a
protein-protein interaction network, different algorithms such as
shortest-path, random walk with restart and network propagation are exploited.
By using these algorithms, initial scores are given to genes within the
network. Furthermore, by looking through diseases with similar symptoms and
also comorbid diseases and by extracting their causing genes, the gene scores
are recalculated. We also use gene-phenotype relations for an additional
scoring of the candidate genes. Our method is validated and compared with other
prioritization methods in leave one-out cross-validation and the comparison
results show the better performance of the HybridRanker.

26
The categories of this paper are: bayes-an
0
The categories of this paper are: hep-ph
9
The categories of this paper are: nlin
11
The categories of this paper are: hep-lat
19
The categories of this paper are: eess
15
The categories of this paper are: nucl-ex
18
The categories of this paper are: econ
27
The categories of this paper are: comp-gas
14
The categories of this paper are: math-ph
3
The categories of this paper are: physics
31
The categories of this paper are: ao-sci
29
The categories of this paper are: funct-an
34
The categories of this paper are: chem-ph
36
The categories of this paper are: cmp-lg
2
The categories of this paper are: math
8
The categories of this paper are: hep-ex