Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and
  macrophages   A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5
(MBG-75S) has been synthetized as a potential bioceramic for bone regeneration
purposes. X-ray diffraction (XRD), Fourier transform infrared spectroscopy
(FT-IR), nitrogen adsorption studies and transmission electron microscopy (TEM)
demonstrated that MBG-75Spossess a highly ordered mesoporous structure with
high surface area and porosity, which would explain the high ionic exchange
rate (mainly calcium and silicon soluble species) with the surrounded media.
MBG-75S showed high biocompatibility in contact with Saos-2 osteoblast-like
cells. Concentrations up to 1 mg/ml did not lead to significant alterations on
either morphology or cell cycle. Regarding the effects on osteoclasts, MBG-75S
allowed the differentiation of RAW-264.7 macrophages into osteoclast-like cells
but exhibiting a decreased resorptive activity. These results point out that
MBG-75S does not inhibit osteoclastogenesis but reduces the osteoclast
boneresorbing capability. Finally, in vitro studies focused on the innate
immune response, evidenced that MBG-75S allows the proliferation of macrophages
without inducing their polarization towards the M1 pro-inflammatory phenotype.
This in vitro behavior is indicative that MBG-75S would just induce the
required innate immune response without further inflammatory complications
under in vivo conditions. The overall behavior respect to osteoblasts,
osteoclasts and macrophages, makes this MBG a very interesting candidate for
bone grafting applications in osteoporotic patients.

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The categories of this paper are: chem-ph
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The categories of this paper are: solv-int
6
The categories of this paper are: astro-ph
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The categories of this paper are: mtrl-th
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The categories of this paper are: supr-con
3
The categories of this paper are: physics
7
The categories of this paper are: hep-th
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The categories of this paper are: funct-an
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The categories of this paper are: hep-ex
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The categories of this paper are: math-ph
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The categories of this paper are: alg-geom
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The categories of this paper are: nucl-ex
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The categories of this paper are: adap-org
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The categories of this paper are: nlin
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The categories of this paper are: bayes-an
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The categories of this paper are: plasm-ph