Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Using the Gene Ontology Hierarchy when Predicting Gene Function   The problem of multilabel classification when the labels are related through
a hierarchical categorization scheme occurs in many application domains such as
computational biology. For example, this problem arises naturally when trying
to automatically assign gene function using a controlled vocabularies like Gene
Ontology. However, most existing approaches for predicting gene functions solve
independent classification problems to predict genes that are involved in a
given function category, independently of the rest. Here, we propose two simple
methods for incorporating information about the hierarchical nature of the
categorization scheme. In the first method, we use information about a gene's
previous annotation to set an initial prior on its label. In a second approach,
we extend a graph-based semi-supervised learning algorithm for predicting gene
function in a hierarchy. We show that we can efficiently solve this problem by
solving a linear system of equations. We compare these approaches with a
previous label reconciliation-based approach. Results show that using the
hierarchy information directly, compared to using reconciliation methods,
improves gene function prediction.

36
The categories of this paper are: cmp-lg
19
The categories of this paper are: eess
34
The categories of this paper are: chem-ph
28
The categories of this paper are: alg-geom
12
The categories of this paper are: nucl-th
33
The categories of this paper are: plasm-ph
4
The categories of this paper are: cond-mat
7
The categories of this paper are: hep-th
22
The categories of this paper are: chao-dyn
27
The categories of this paper are: comp-gas
24
The categories of this paper are: dg-ga
31
The categories of this paper are: ao-sci
35
The categories of this paper are: mtrl-th
3
The categories of this paper are: physics
32
The categories of this paper are: atom-ph
17
The categories of this paper are: q-fin