Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Reducing complexity and unidentifiability when modelling human atrial
  cells   Mathematical models of a cellular action potential in cardiac modelling have
become increasingly complex, particularly in gating kinetics which control the
opening and closing of individual ion channel currents. As cardiac models
advance towards use in personalised medicine to inform clinical
decision-making, it is critical to understand the uncertainty hidden in
parameter estimates from their calibration to experimental data. This study
applies approximate Bayesian computation to re-calibrate the gating kinetics of
four ion channels in two existing human atrial cell models to their original
datasets, providing a measure of uncertainty and indication of potential issues
with selecting a single unique value given the available experimental data. Two
approaches are investigated to reduce the uncertainty present: re-calibrating
the models to a more complete dataset and using a less complex formulation with
fewer parameters to constrain. The re-calibrated models are inserted back into
the full cell model to study the overall effect on the action potential. The
use of more complete datasets does not eliminate uncertainty present in
parameter estimates. The less complex model, particularly for the fast sodium
current, gave a better fit to experimental data alongside lower parameter
uncertainty and improved computational speed.

23
The categories of this paper are: solv-int
20
The categories of this paper are: acc-phys
29
The categories of this paper are: funct-an
7
The categories of this paper are: hep-th
27
The categories of this paper are: comp-gas
18
The categories of this paper are: econ
13
The categories of this paper are: quant-ph
37
The categories of this paper are: supr-con
34
The categories of this paper are: chem-ph
15
The categories of this paper are: nucl-ex
8
The categories of this paper are: hep-ex
14
The categories of this paper are: math-ph
35
The categories of this paper are: mtrl-th
30
The categories of this paper are: q-alg
4
The categories of this paper are: cond-mat
33
The categories of this paper are: plasm-ph