Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Transmembrane Batten disease proteins interact with a shared network of vesicle sorting proteins to regulate synaptic composition and function. Batten disease is unique among lysosomal storage disorders for the early and profound manifestation in the central nervous system, but little is known regarding potential neuron-specific roles for the disease-associated proteins. We demonstrate substantial overlap in the protein interactomes of three transmembrane Batten proteins (CLN3, CLN6, and CLN8), and that their absence leads to synaptic depletion of key partners (i.e. SNAREs and tethers) and aberrant synaptic SNARE dynamics in vivo, demonstrating a novel shared etiology.
11
The categories of this paper are: cognition
6
The categories of this paper are: plant
13
The categories of this paper are: animal
3
The categories of this paper are: evolutionary
29
The categories of this paper are: education
5
The categories of this paper are: cell
7
The categories of this paper are: ecology
32
The categories of this paper are: zoology
25
The categories of this paper are: bioengineering
26
The categories of this paper are: biochemistry
22
The categories of this paper are: physiology
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The categories of this paper are: epidemiology
0
The categories of this paper are: genetics
21
The categories of this paper are: toxicology
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The categories of this paper are: microbiology
24
The categories of this paper are: cancer