Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine RNA-based vaccines against SARS-CoV-2 are critical to limiting COVID-19 severity and spread. Cellular mechanisms driving antigen-specific responses to these vaccines, however, remain uncertain. We used single-cell technologies to identify and characterized antigen-specific cells and antibody responses to the RNA vaccine BNT162b2 in longitudinal samples from a cohort of healthy donors. Mass cytometry and machine learning pinpointed a novel expanding, population of antigen-specific non-canonical memory CD4+ and CD8+ T cells. B cell sequencing suggested progression from IgM, with apparent cross-reactivity to endemic coronaviruses, to SARS-CoV-2-specific IgA and IgG memory B cells and plasmablasts. Responding lymphocyte populations correlated with eventual SARS-CoV-2 IgG and a donor lacking these cell populations failed to sustain SARS-CoV-2-specific antibodies and experienced breakthrough infection. These integrated proteomic and genomic platforms reveal an antigen-specific cellular basis of RNA vaccine-based immunity.

ONE SENTENCE SUMMARYSingle-cell profiling reveals the cellular basis of the antigen-specific response to the BNT162b2 SARS-CoV-2 RNA vaccine.
19
The categories of this paper are: epidemiology
11
The categories of this paper are: cognition
18
The categories of this paper are: systems
30
The categories of this paper are: scientific
4
The categories of this paper are: neuroscience
15
The categories of this paper are: developmental
32
The categories of this paper are: zoology
10
The categories of this paper are: and
12
The categories of this paper are: behavior
25
The categories of this paper are: bioengineering
29
The categories of this paper are: education
0
The categories of this paper are: genetics
8
The categories of this paper are: genomics
7
The categories of this paper are: ecology
9
The categories of this paper are: synthetic
21
The categories of this paper are: toxicology