Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Infection severity across scales in multi-strain immuno-epidemiological
  Dengue model structured by host antibody level   Infection by distinct Dengue virus serotypes and host immunity are
intricately linked. In particular, certain levels of cross-reactive antibodies
in the host may actually enhance infection severity leading to Dengue
hemorrhagic fever (DHF). The coupled immunological and epidemiological dynamics
of Dengue calls for a multi-scale modeling approach. In this work, we formulate
a within-host model which mechanistically recapitulates characteristics of
antibody dependent enhancement (ADE) in Dengue infection. The within-host scale
is then linked to epidemiological spread by a vector-host partial differential
equation model structured by host antibody level. The coupling allows for
dynamic population-wide antibody levels to be tracked through primary and
secondary infections by distinct Dengue strains, along with waning of
cross-protective immunity after primary infection. Analysis of both the
within-host and between-host systems are conducted. Stability results in the
epidemic model are formulated via basic and invasion reproduction numbers as a
function of immunological variables. Additionally, we develop numerical methods
in order to simulate the multi-scale model and assess the influence of
parameters on disease spread and DHF prevalence in the population.

32
The categories of this paper are: atom-ph
35
The categories of this paper are: mtrl-th
25
The categories of this paper are: patt-sol
17
The categories of this paper are: q-fin
16
The categories of this paper are: stat
19
The categories of this paper are: eess
15
The categories of this paper are: nucl-ex
33
The categories of this paper are: plasm-ph
7
The categories of this paper are: hep-th
8
The categories of this paper are: hep-ex
23
The categories of this paper are: solv-int
9
The categories of this paper are: nlin
24
The categories of this paper are: dg-ga
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The categories of this paper are: funct-an
37
The categories of this paper are: supr-con
36
The categories of this paper are: cmp-lg