Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A systematic approach to improving the reliability and scale of evidence
  from health care data   Concerns over reproducibility in science extend to research using existing
healthcare data; many observational studies investigating the same topic
produce conflicting results, even when using the same data. To address this
problem, we propose a paradigm shift. The current paradigm centers on
generating one estimate at a time using a unique study design with unknown
reliability and publishing (or not) one estimate at a time. The new paradigm
advocates for high-throughput observational studies using consistent and
standardized methods, allowing evaluation, calibration, and unbiased
dissemination to generate a more reliable and complete evidence base. We
demonstrate this new paradigm by comparing all depression treatments for a set
of outcomes, producing 17,718 hazard ratios, each using methodology on par with
state-of-the-art studies. We furthermore include control hypotheses to evaluate
and calibrate our evidence generation process. Results show good transitivity
and consistency between databases, and agree with four out of the five findings
from clinical trials. The distribution of effect size estimates reported in
literature reveals an absence of small or null effects, with a sharp cutoff at
p = 0.05. No such phenomena were observed in our results, suggesting more
complete and more reliable evidence.

2
The categories of this paper are: math
18
The categories of this paper are: econ
30
The categories of this paper are: q-alg
36
The categories of this paper are: cmp-lg
0
The categories of this paper are: hep-ph
19
The categories of this paper are: eess
9
The categories of this paper are: nlin
6
The categories of this paper are: astro-ph
12
The categories of this paper are: nucl-th
5
The categories of this paper are: gr-qc
33
The categories of this paper are: plasm-ph
7
The categories of this paper are: hep-th
24
The categories of this paper are: dg-ga
25
The categories of this paper are: patt-sol
27
The categories of this paper are: comp-gas
11
The categories of this paper are: hep-lat