Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood B cells generate antibodies that are essential for immune protection. Major events driving B cell responses occur in lymphoid tissues, which guide antigen acquisition and support cellular interactions, yet complexities of B cell subsets in human lymphoid tissues are poorly understood. Here we perform undirected, global profiling of B cells in matched human lymphoid tissues from deceased transplant organ donors and tracked dissemination of B cell clones. In addition to identifying unanticipated features of tissue-based B cell differentiation, we resolve two clonally independent subsets of marginal zone B cells that differ in cell surface and transcriptomic profiles, tendency to disseminate, distribution bias within splenic marginal zone microenvironment and immunoglobulin repertoire diversity and hypermutation frequency. Each subset is represented in spleen, gut-associated lymphoid tissue, mesenteric lymph node, and also blood. Thus, we provide clarity and diffuse controversy surrounding human MZB - the  elephant in the room of human B cell biology.
14
The categories of this paper are: biophysics
0
The categories of this paper are: genetics
32
The categories of this paper are: zoology
27
The categories of this paper are: pathology
21
The categories of this paper are: toxicology
5
The categories of this paper are: cell
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The categories of this paper are: pharmacology
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The categories of this paper are: microbiology
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The categories of this paper are: genomics
25
The categories of this paper are: bioengineering
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The categories of this paper are: biology
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The categories of this paper are: communication
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The categories of this paper are: behavior
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The categories of this paper are: bioinformatics
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The categories of this paper are: animal
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The categories of this paper are: epidemiology