Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection There is an urgent need to understand how SARS-CoV-2 infects the airway epithelium and in a subset of individuals leads to severe illness or death. Induced pluripotent stem cells (iPSCs) provide a near limitless supply of human cells that can be differentiated into cell types of interest, including airway epithelium, for disease modeling. We present a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that is permissive to SARS-CoV-2 infection. Subsets of iPSC-airway cells express the SARS-CoV-2 entry factors ACE2 and TMPRSS2. Multiciliated cells are the primary initial target of SARS-CoV-2 infection. Upon infection with SARS-CoV-2, iPSC-airway cells generate robust interferon and inflammatory responses and treatment with remdesivir or camostat methylate causes a decrease in viral propagation and entry, respectively. In conclusion, iPSC-derived airway cells provide a physiologically relevant in vitro model system to interrogate the pathogenesis of, and develop treatment strategies for, COVID-19 pneumonia.

Highlights and eTOC blurbO_LISubsets of human iPSC-airway epithelial cells express SARS-Co-V entry factors ACE2 and TMPRSS2.
C_LIO_LIiPSC-airway cells are permissive to SARS-CoV-2 infection via multiciliated cells.
C_LIO_LISARS-CoV-2 infection of iPSC-airway leads to a robust interferon and inflammatory response.
C_LIO_LIiPSC-airway is a physiologically relevant model to study SARS-CoV-2 infection.
C_LI
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The categories of this paper are: zoology
29
The categories of this paper are: education
27
The categories of this paper are: pathology
28
The categories of this paper are: communication
19
The categories of this paper are: epidemiology
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The categories of this paper are: pharmacology
15
The categories of this paper are: developmental
26
The categories of this paper are: biochemistry
18
The categories of this paper are: systems
10
The categories of this paper are: and
9
The categories of this paper are: synthetic
21
The categories of this paper are: toxicology
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The categories of this paper are: behavior
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The categories of this paper are: animal
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The categories of this paper are: genomics
4
The categories of this paper are: neuroscience