Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins For intrinsically disordered proteins (IDPs), a pressing question is how sequence codes for function. Dynamics serves as a crucial link, reminiscent of the role of structure in sequence-function relations of structured proteins. To define general rules governing sequence-dependent backbone dynamics, we carried out long molecular dynamics simulations of eight IDPs. Blocks of residues exhibiting large amplitudes in slow dynamics are rigidified by local inter-residue interactions or secondary structures. A long region or an entire IDP can be slowed down by long-range contacts or secondary- structure packing. On the other hand, glycines promote fast dynamics and either demarcate rigid blocks or facilitate multiple modes of local and long-range inter-residue interactions. The sequence-dependent backbone dynamics endows IDPs with versatile response to binding partners, with some blocks recalcitrant while others readily adapting to intermolecular interactions.
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The categories of this paper are: evolutionary
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The categories of this paper are: epidemiology
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The categories of this paper are: developmental
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The categories of this paper are: cognition
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The categories of this paper are: synthetic
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The categories of this paper are: cell
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The categories of this paper are: physiology
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The categories of this paper are: bioinformatics
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The categories of this paper are: education
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The categories of this paper are: animal
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The categories of this paper are: microbiology
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The categories of this paper are: communication
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The categories of this paper are: pharmacology
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The categories of this paper are: pathology
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The categories of this paper are: toxicology
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The categories of this paper are: immunology