Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Codon Context Optimization in Synthetic Gene Design   Advances in de novo synthesis of DNA and computational gene design methods
make possible the customization of genes by direct manipulation of features
such as codon bias and mRNA secondary structure. Codon context is another
feature significantly affecting mRNA translational efficiency, but existing
methods and tools for evaluating and designing novel optimized protein coding
sequences utilize untested heuristics and do not provide quantifiable
guarantees on design quality. In this study we examine statistical properties
of codon context measures in an effort to better understand the phenomenon. We
analyze the computational complexity of codon context optimization and design
exact and efficient heuristic gene recoding algorithms under reasonable
constraint models. We also present a web-based tool for evaluating codon
context bias in the appropriate context.

13
The categories of this paper are: quant-ph
28
The categories of this paper are: alg-geom
18
The categories of this paper are: econ
29
The categories of this paper are: funct-an
37
The categories of this paper are: supr-con
4
The categories of this paper are: cond-mat
22
The categories of this paper are: chao-dyn
36
The categories of this paper are: cmp-lg
6
The categories of this paper are: astro-ph
34
The categories of this paper are: chem-ph
7
The categories of this paper are: hep-th
26
The categories of this paper are: bayes-an
33
The categories of this paper are: plasm-ph
11
The categories of this paper are: hep-lat
27
The categories of this paper are: comp-gas
5
The categories of this paper are: gr-qc