Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A multivariate variable selection approach for analyzing LC-MS
  metabolomics data   Omic data are characterized by the presence of strong dependence structures
that result either from data acquisition or from some underlying biological
processes. In metabolomics, for instance, data resulting from Liquid
Chromatography-Mass Spectrometry (LC-MS) -- a technique which gives access to a
large coverage of metabolites -- exhibit such patterns. These data sets are
typically used to find the metabolites characterizing a phenotype of interest
associated with the samples. However, applying some statistical procedures that
do not adjust the variable selection step to the dependence pattern may result
in a loss of power and the selection of spurious variables. The goal of this
paper is to propose a variable selection procedure in the multivariate linear
model that accounts for the dependence structure of the multiple outputs which
may lead in the LC-MS framework to the selection of more relevant metabolites.
We propose a novel Lasso-based approach in the multivariate framework of the
general linear model taking into account the dependence structure by using
various modelings of the covariance matrix of the residuals. Our numerical
experiments show that including the estimation of the covariance matrix of the
residuals in the Lasso criterion dramatically improves the variable selection
performance. Our approach is also successfully applied to a LC-MS data set made
of African copals samples for which it is able to provide a small list of
metabolites without altering the phenotype discrimination. Our methodology is
implemented in the R package MultiVarSel which is available from the CRAN
(Comprehensive R Archive Network).

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The categories of this paper are: math-ph
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The categories of this paper are: astro-ph
29
The categories of this paper are: funct-an
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The categories of this paper are: comp-gas
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The categories of this paper are: gr-qc
35
The categories of this paper are: mtrl-th
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The categories of this paper are: hep-th
34
The categories of this paper are: chem-ph
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The categories of this paper are: hep-lat
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The categories of this paper are: bayes-an
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The categories of this paper are: q-alg
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The categories of this paper are: cmp-lg
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The categories of this paper are: q-fin
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The categories of this paper are: econ
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The categories of this paper are: nucl-ex
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The categories of this paper are: patt-sol