Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Two-Stage Penalized Regression Screening to Detect Biomarker-Treatment
  Interactions in Randomized Clinical Trials   High-dimensional biomarkers such as genomics are increasingly being measured
in randomized clinical trials. Consequently, there is a growing interest in
developing methods that improve the power to detect biomarker-treatment
interactions. We adapt recently proposed two-stage interaction detecting
procedures in the setting of randomized clinical trials. We also propose a new
stage 1 multivariate screening strategy using ridge regression to account for
correlations among biomarkers. For this multivariate screening, we prove the
asymptotic between-stage independence, required for family-wise error rate
control, under biomarker-treatment independence. Simulation results show that
in various scenarios, the ridge regression screening procedure can provide
substantially greater power than the traditional one-biomarker-at-a-time
screening procedure in highly correlated data. We also exemplify our approach
in two real clinical trial data applications.

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The categories of this paper are: astro-ph
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The categories of this paper are: gr-qc
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The categories of this paper are: math-ph
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The categories of this paper are: eess
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The categories of this paper are: funct-an
8
The categories of this paper are: hep-ex
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The categories of this paper are: acc-phys
35
The categories of this paper are: mtrl-th
28
The categories of this paper are: alg-geom
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The categories of this paper are: q-fin
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The categories of this paper are: supr-con
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The categories of this paper are: hep-th
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The categories of this paper are: hep-ph
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The categories of this paper are: nlin
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The categories of this paper are: dg-ga
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The categories of this paper are: bayes-an