Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The role of cellular coupling in the spontaneous generation of
  electrical activity in uterine tissue   The spontaneous emergence of contraction-inducing electrical activity in the
uterus at the beginning of labor remains poorly understood, partly due to the
seemingly contradictory observation that isolated uterine cells are not
spontaneously active. It is known, however, that the expression of gap
junctions increases dramatically in the approach to parturition, which results
in a significant increase in inter-cellular electrical coupling. In this paper,
we build upon previous studies of the activity of electrically excitable smooth
muscle cells (myocytes) and investigate the mechanism through which the
coupling of these cells to electrically passive cells results in the generation
of spontaneous activity in the uterus. Using a recently developed, realistic
model of uterine muscle cell dynamics, we investigate a system consisting of a
myocyte coupled to passive cells. We then extend our analysis to a simple
two-dimensional lattice model of the tissue, with each myocyte being coupled to
its neighbors, as well as to a random number of passive cells. We observe that
different dynamical regimes can be observed over a range of gap junction
conductances: at low coupling strength, the activity is confined to cell
clusters, while the activity for high coupling may spread across the entire
tissue. Additionally, we find that the system supports the spontaneous
generation of spiral wave activity. Our results are both qualitatively and
quantitatively consistent with observations from in vitro experiments. In
particular, we demonstrate that an increase in inter-cellular electrical
coupling, for realistic parameter values, strongly facilitates the appearance
of spontaneous action potentials that may eventually lead to parturition.

18
The categories of this paper are: econ
8
The categories of this paper are: hep-ex
22
The categories of this paper are: chao-dyn
35
The categories of this paper are: mtrl-th
26
The categories of this paper are: bayes-an
2
The categories of this paper are: math
0
The categories of this paper are: hep-ph
29
The categories of this paper are: funct-an
21
The categories of this paper are: adap-org
1
The categories of this paper are: cs
32
The categories of this paper are: atom-ph
33
The categories of this paper are: plasm-ph
15
The categories of this paper are: nucl-ex
25
The categories of this paper are: patt-sol
4
The categories of this paper are: cond-mat
5
The categories of this paper are: gr-qc