Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: First-passage times in complex energy landscapes: a case study with
  nonmuscle myosin II assembly   Complex energy landscapes often arise in biological systems, e.g. for protein
folding, biochemical reactions or intracellular transport processes. Their
physical effects are often reflected in the first-passage times arising from
these energy landscapes. However, their calculation is notoriously challenging
and it is often difficult to identify the most relevant features of a given
energy landscape. Here we show how this can be achieved by coarse-graining the
Fokker-Planck equation to a master equation and decomposing its first-passage
times in an iterative process. We apply this method to the electrostatic
interaction between two rods of nonmuscle myosin II (NM2), which is the main
molecular motor for force generation in nonmuscle cells. Energy landscapes are
computed directly from the amino acid sequences of the three different
isoforms. Our approach allows us to identify their most likely arrangements
during self-assembly into nonmuscle myosin II minifilaments and how they change
under force. In particular, we find that antiparallel configurations are more
stable than parallel ones, but also show more changes under mechanical loading.
Our work demonstrates the rich dynamics that can be expected for NM2-assemblies
under mechanical load and in general shows how one can identify the most
relevant energy barriers in complex energy landscapes.

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The categories of this paper are: mtrl-th
18
The categories of this paper are: econ
14
The categories of this paper are: math-ph
16
The categories of this paper are: stat
32
The categories of this paper are: atom-ph
12
The categories of this paper are: nucl-th
15
The categories of this paper are: nucl-ex
28
The categories of this paper are: alg-geom
1
The categories of this paper are: cs
2
The categories of this paper are: math
7
The categories of this paper are: hep-th
20
The categories of this paper are: acc-phys
19
The categories of this paper are: eess
3
The categories of this paper are: physics
8
The categories of this paper are: hep-ex
5
The categories of this paper are: gr-qc