Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Characterization of the 3D microstructure of Ibuprofen tablets by means
  of synchrotron tomography   We present a methodology to characterize the 3D microstructure of Ibuprofen
tablets, which strongly influences the strength and solubility kinetics of the
final formulation, by means of synchrotron tomography. A physically coherent
trinarization for greyscale images of Ibuprofen tablets consisting of the three
phases microcrystalline cellulose, Ibuprofen and pores is presented. For this
purpose, a hybrid approach is developed combining a trinarization by means of
statistical learning with a trinarization based on a watershed algorithm. This
hybrid approach allows us to compute microstructure characteristics of tablets
using image analysis. A comparison with experimental results shows that there
is a significant amount of pores which is below the resolution limit and
results from image analysis let us conjecture that these pores make up the
major part of the surface between pores and solid. Furthermore, we compute
microstructure characteristics, which are experimentally not accessible such as
local percolation probabilities and chord length distribution functions. Both
characteristics are meaningful in order to quantify the influence of tablet
compaction on its microstructure. The presented approach can be used to get
better insights into the relationship between production parameters and
microstructure characteristics based on 3D image data of Ibuprofen tablets
manufactured under different conditions.

31
The categories of this paper are: ao-sci
1
The categories of this paper are: cs
16
The categories of this paper are: stat
30
The categories of this paper are: q-alg
2
The categories of this paper are: math
6
The categories of this paper are: astro-ph
17
The categories of this paper are: q-fin
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The categories of this paper are: funct-an
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The categories of this paper are: dg-ga
11
The categories of this paper are: hep-lat
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The categories of this paper are: alg-geom
14
The categories of this paper are: math-ph
18
The categories of this paper are: econ
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The categories of this paper are: solv-int
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The categories of this paper are: quant-ph
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The categories of this paper are: eess