Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: The testis-specific transcription factor TCFL5 responds to A MYBto elaborate the male meiotic program in placental mammals In male mice, the transcription factor (TF) A-MYB initiates reprogramming of gene expression after spermatogonia enter meiosis. We report that A-MYB activates Tcfl5, a testis-specific TF first produced in pachytene spermatocytes. Subsequently, A-MYB and TCFL5 reciprocally reinforce their own transcription to establish an extensive circuit that regulates meiosis. TCFL5 promotes transcription of genes required for mRNA turnover, pachytene piRNA production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5em1/em1 mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis.
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The categories of this paper are: bioinformatics
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The categories of this paper are: and
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The categories of this paper are: pharmacology
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The categories of this paper are: pathology
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The categories of this paper are: bioengineering
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The categories of this paper are: communication
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The categories of this paper are: biochemistry
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The categories of this paper are: scientific
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The categories of this paper are: biology
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The categories of this paper are: plant
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The categories of this paper are: animal
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The categories of this paper are: genomics
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The categories of this paper are: cognition
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The categories of this paper are: biophysics
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The categories of this paper are: behavior
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The categories of this paper are: systems