Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and
  death from lower respiratory tract infection   In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the
viral replication phase is often followed by hyperinflammation, which can lead
to acute respiratory distress syndrome, multi-organ failure, and death. We
previously demonstrated that alpha-1 adrenergic receptor ($\alpha_1$-AR)
antagonists can prevent hyperinflammation and death in mice. Here, we conducted
retrospective analyses in two cohorts of patients with acute respiratory
distress (ARD, n=18,547) and three cohorts with pneumonia (n=400,907).
Federated across two ARD cohorts, we find that patients exposed to
$\alpha_1$-AR antagonists, as compared to unexposed patients, had a 34%
relative risk reduction for mechanical ventilation and death (OR=0.70,
p=0.021). We replicated these methods on three pneumonia cohorts, all with
similar effects on both outcomes. All results were robust to sensitivity
analyses. These results highlight the urgent need for prospective trials
testing whether prophylactic use of $\alpha_1$-AR antagonists ameliorates lower
respiratory tract infection-associated hyperinflammation and death, as observed
in COVID-19.

29
The categories of this paper are: funct-an
7
The categories of this paper are: hep-th
33
The categories of this paper are: plasm-ph
24
The categories of this paper are: dg-ga
9
The categories of this paper are: nlin
16
The categories of this paper are: stat
1
The categories of this paper are: cs
27
The categories of this paper are: comp-gas
17
The categories of this paper are: q-fin
23
The categories of this paper are: solv-int
30
The categories of this paper are: q-alg
14
The categories of this paper are: math-ph
32
The categories of this paper are: atom-ph
25
The categories of this paper are: patt-sol
19
The categories of this paper are: eess
0
The categories of this paper are: hep-ph