Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Hippocampal Interneuronal Dysfunction and Hyperexcitability in Porcine Model of Concussion Cognitive impairment is a common symptom following mild traumatic brain injury (mTBI or concussion) and can persist for years in some individuals. While the underlying mechanisms driving these impairments remain unknown, structural changes in the hippocampus post-mTBI have been reported in human patients, as well as electrophysiological changes in rodents following impact models of TBI. In addition, slice preparations from a closed-head, rotational acceleration injury (RAI) in swine showed reduced axonal function and hippocampal circuitry disruption. However, electrophysiological changes in neurons and their subtypes have not been examined. Using in vivo electrophysiology techniques, we examined the laminar oscillatory field potentials and single unit activity in the intact hippocampal network at 7 days post-RAI in anesthetized minipigs. Concussion altered the electrophysiological properties of pyramidal cells and interneurons differently in area CA1. Specifically, while firing rate and burst occurrence of CA1 interneurons were significantly decreased post-mTBI, these parameters were unchanged in putative CA1 pyramidal cells. However, pyramidal CA1 cells in TBI animals were significantly less entrained to hippocampal gamma (40 - 80 Hz) oscillations. In addition, stimulation of the Schaffer collaterals revealed hyperexcitability in the laminar CA1 response post-mTBI. Finally, computational simulations suggest that the reported changes in interneuronal firing rate and action potentials may be due to alterations in voltage-gated sodium channels. These data demonstrate that a single concussion can lead to significant neuronal and circuit level changes in the hippocampus, and that the loss of pyramidal gamma entrainment and changes in interneuronal firing may be important contributors to cognitive dysfunction following mTBI.
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The categories of this paper are: scientific
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The categories of this paper are: plant
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The categories of this paper are: cancer
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The categories of this paper are: cognition
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The categories of this paper are: paleontology
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The categories of this paper are: communication
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The categories of this paper are: evolutionary
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The categories of this paper are: zoology
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The categories of this paper are: pathology
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The categories of this paper are: physiology
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The categories of this paper are: epidemiology
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The categories of this paper are: biology
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The categories of this paper are: genetics
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The categories of this paper are: bioengineering
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The categories of this paper are: and
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The categories of this paper are: animal