Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: When it Pays to Rush: Interpreting Morphogen Gradients Prior to
  Steady-State   During development, morphogen gradients precisely determine the position of
gene expression boundaries despite the inevitable presence of fluctuations.
Recent experiments suggest that some morphogen gradients may be interpreted
prior to reaching steady-state. Theoretical work has predicted that such
systems will be more robust to embryo-to-embryo fluctuations. By analysing two
experimentally motivated models of morphogen gradient formation, we investigate
the positional precision of gene expression boundaries determined by
pre-steady-state morphogen gradients in the presence of embryo-to-embryo
fluctuations, internal biochemical noise and variations in the timing of
morphogen measurement. Morphogens that are direct transcription factors are
found to be particularly sensitive to internal noise when interpreted prior to
steady-state, disadvantaging early measurement, even in the presence of large
embryo-to-embryo fluctuations. Morphogens interpreted by cell-surface receptors
can be measured prior to steady-state without significant decrease in
positional precision provided fluctuations in the timing of measurement are
small. Applying our results to experiment, we predict that Bicoid, a
transcription factor morphogen in Drosophila, is unlikely to be interpreted
prior to reaching steady-state. We also predict that Activin in Xenopus and
Nodal in zebrafish, morphogens interpreted by cell-surface receptors, can be
decoded in pre-steady-state.

37
The categories of this paper are: supr-con
8
The categories of this paper are: hep-ex
2
The categories of this paper are: math
25
The categories of this paper are: patt-sol
33
The categories of this paper are: plasm-ph
20
The categories of this paper are: acc-phys
27
The categories of this paper are: comp-gas
16
The categories of this paper are: stat
7
The categories of this paper are: hep-th
28
The categories of this paper are: alg-geom
30
The categories of this paper are: q-alg
32
The categories of this paper are: atom-ph
14
The categories of this paper are: math-ph
0
The categories of this paper are: hep-ph
26
The categories of this paper are: bayes-an
22
The categories of this paper are: chao-dyn