Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Combination Chemotherapy Optimization with Discrete Dosing   Chemotherapy is one of the primary modalities of cancer treatment.
Chemotherapy drug administration is a complex problem that often requires
expensive clinical trials to evaluate potential regimens. One way to alleviate
this burden and better inform future trials is to build reliable models for
drug administration. Previous chemotherapy optimization models have mainly
relied on optimal control, which does not lend itself to capturing complex and
vital operational constraints in chemotherapy planning involving discrete
decisions, such as doses via pills and rest periods. In addition, most of the
existing models for chemotherapy optimization lack an explicit toxicity measure
and impose toxicity constraints primarily through (fixed) limits on drug
concentration. The existing stochastic optimization models also focus on
maximizing the probability of cure when tumor heterogeneity is uncertain. In
this paper, we develop a mixed-integer program for combination chemotherapy
(utilization of multiple drugs) optimization that incorporates various
important operational constraints and, besides dose and concentration limits,
controls treatment toxicity based on its effect on the count of white blood
cells. To address the uncertainty of tumor heterogeneity, we propose chance
constraints that guarantee reaching an operable tumor size with a high
probability in a neoadjuvant setting. We present analytical results pertinent
to the accuracy of the model in representing biological processes of
chemotherapy and establish its merit for clinical applications through a
numerical study of breast cancer.

15
The categories of this paper are: nucl-ex
19
The categories of this paper are: eess
37
The categories of this paper are: supr-con
34
The categories of this paper are: chem-ph
10
The categories of this paper are: q-bio
7
The categories of this paper are: hep-th
22
The categories of this paper are: chao-dyn
35
The categories of this paper are: mtrl-th
20
The categories of this paper are: acc-phys
36
The categories of this paper are: cmp-lg
27
The categories of this paper are: comp-gas
14
The categories of this paper are: math-ph
21
The categories of this paper are: adap-org
9
The categories of this paper are: nlin
0
The categories of this paper are: hep-ph
5
The categories of this paper are: gr-qc