Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Single-molecule simultaneous profiling of DNA methylation and DNA-protein interactions with Nanopore-DamID DNA-protein interactions and cytosine methylation control eukaryotic gene expression. Here, we present an approach to simultaneously detect cytosine methylation and DNA-protein interactions from single molecules, through selective sequencing of adenine-labelled DNA. Applying this approach to LaminB1-associated heterochromatin domains, we identify strict CpG methylation maintenance at transcriptional start sites amidst a generalised relaxation of methylation, potentially to prevent ectopic and aberrant heterochromatic gene expression.
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The categories of this paper are: animal
15
The categories of this paper are: developmental
27
The categories of this paper are: pathology
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The categories of this paper are: molecular
6
The categories of this paper are: plant
5
The categories of this paper are: cell
2
The categories of this paper are: biology
26
The categories of this paper are: biochemistry
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The categories of this paper are: microbiology
28
The categories of this paper are: communication
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The categories of this paper are: toxicology
0
The categories of this paper are: genetics
22
The categories of this paper are: physiology
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The categories of this paper are: immunology
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The categories of this paper are: bioengineering
3
The categories of this paper are: evolutionary