Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Stretching Single Domain Proteins: Phase Diagram and Kinetics of
  Force-Induced Unfolding   Single molecule force spectroscopy reveals unfolding of domains in titin upon
stretching. We provide a theoretical framework for these experiments by
computing the phase diagrams for force-induced unfolding of single domain
proteins using lattice models. The results show that two-state folders (at zero
force) unravel cooperatively whereas stretching of non-two-state folders occurs
through intermediates. The stretching rates of individual molecules show great
variations reflecting the heterogeneity of force-induced unfolding pathways.
The approach to the stretched state occurs in a step-wise "quantized" manner.
Unfolding dynamics depends sensitively on topology. The unfolding rates
increase exponentially with force f till an optimum value which is determined
by the barrier to unfolding when f=0. A mapping of these results to proteins
shows qualitative agreement with force-induced unfolding of Ig-like domains in
titin. We show that single molecule force spectroscopy can be used to map the
folding free energy landscape of proteins in the absence of denaturants.

17
The categories of this paper are: q-fin
37
The categories of this paper are: supr-con
36
The categories of this paper are: cmp-lg
2
The categories of this paper are: math
6
The categories of this paper are: astro-ph
1
The categories of this paper are: cs
3
The categories of this paper are: physics
30
The categories of this paper are: q-alg
15
The categories of this paper are: nucl-ex
34
The categories of this paper are: chem-ph
26
The categories of this paper are: bayes-an
24
The categories of this paper are: dg-ga
25
The categories of this paper are: patt-sol
5
The categories of this paper are: gr-qc
12
The categories of this paper are: nucl-th
22
The categories of this paper are: chao-dyn