Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression Tumor associated macrophages (TAMs) are a highly plastic stromal cell type which support cancer progression. Using single-cell RNA-sequencing of TAMs from a spontaneous murine model of mammary adenocarcinoma (MMTV-PyMT) we characterize a subset of these cells expressing lymphatic vessel endothelial hyaluronic acid receptor 1 (Lyve-1) which spatially reside proximal to blood vasculature. We demonstrate that Lyve-1+ TAMs support tumor growth and identify a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells which express alpha-smooth muscle actin and phenotypically resemble pericytes. Using photolabeling techniques show that mesenchymal cells maintain their prevalence in the growing tumor through proliferation and uncover a role for Lyve-1+ TAMs in orchestrating a selective platelet-derived growth factor-CC-dependent expansion of the perivascular mesenchymal population, creating a pro-angiogenic niche. This study highlights the inter-reliance of the immune and non-immune stromal network which support cancer progression and provides therapeutic opportunities for tackling the disease.
13
The categories of this paper are: animal
1
The categories of this paper are: bioinformatics
31
The categories of this paper are: paleontology
20
The categories of this paper are: pharmacology
18
The categories of this paper are: systems
29
The categories of this paper are: education
12
The categories of this paper are: behavior
6
The categories of this paper are: plant
11
The categories of this paper are: cognition
26
The categories of this paper are: biochemistry
19
The categories of this paper are: epidemiology
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The categories of this paper are: toxicology
15
The categories of this paper are: developmental
5
The categories of this paper are: cell
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The categories of this paper are: and
23
The categories of this paper are: immunology