Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: A role for Nucleocapsid-specific antibody function in Covid-19 Convalescent plasma therapy COVID-19 convalescent plasma (CCP), a passive polyclonal antibody therapeutic, has exhibited mixed results in the treatment of COVID-19. Given that the therapeutic effect of CCP may extend beyond the ability of SARS-CoV-2-specific antibody binding and neutralization to influence the evolution of the endogenous antibody response, we took a systematic and comprehensive approach to analyze SARS-CoV-2 functional antibody profiles of participants in a randomized controlled trial of CCP treatment of individuals hospitalized with COVID-19 pneumonia where CCP was associated with both decreased mortality and improved clinical severity. Using systems serology, we found that the clinical benefit of CCP is related to a shift towards reduced inflammatory Spike (S) responses and enhanced Nucleocapsid (N) humoral responses. We found CCP had the greatest clinical benefit in participants with low pre-existing anti-SARS-CoV-2 antibody function, rather than S or N antibody levels or participant demographic features. Further, CCP induced immunomodulatory changes to recipient humoral profiles persisted for at least two months, marked by the selective evolution of anti-inflammatory Fc-glycan profiles and persistently expanded nucleocapsid-specific humoral immunity following CCP therapy. Together, our findings identify a novel mechanism of action of CCP, suggest optimal patient characteristics for CCP treatment, identify long-last immunomodulatory effects of CCP, and provide guidance for development of novel N-focused antibody therapeutics for severe COVID-19 hyperinflammation.
50
The categories of this paper are: medical
54
The categories of this paper are: gynecology
67
The categories of this paper are: transplantation
6
The categories of this paper are: and
48
The categories of this paper are: critical
20
The categories of this paper are: psychiatry
51
The categories of this paper are: education
53
The categories of this paper are: pathology
37
The categories of this paper are: aids
38
The categories of this paper are: hiv
44
The categories of this paper are: endocrinology
31
The categories of this paper are: imaging
4
The categories of this paper are: reproductive
64
The categories of this paper are: ophthalmology
2
The categories of this paper are: medicine
12
The categories of this paper are: genomic