Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Restoration of BDNF-TrkB signaling rescues deficits in a mouse model of SCA6 Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease resulting in motor coordination deficits and cerebellar pathology. Expression of brain-derived neurotrophic factor (BDNF) is reduced in several neurodegenerative diseases, including in post-mortem tissue from SCA6 patients. Here, we show that cerebellar BDNF levels are reduced at an early disease stage in a mouse model of SCA6 (SCA684Q/84Q). One month of voluntary exercise was sufficient to elevate BDNF expression, as well as rescue both motor coordination and cerebellar Purkinje cell firing rate deficits. A BDNF mimetic, 7,8-dihydroxyflavone (7,8-DHF) likewise improved motor coordination and reversed Purkinje cell firing rate deficits, suggesting that exercise acts via BDNF-TrkB signaling. Prolonged chronic 7,8-DHF administration rescued ataxia when treatment commenced near disease onset, but was ineffective when treatment was started late. These data suggest that 7,8-DHF, which is orally bioavailable and crosses the blood-brain barrier, is a promising therapeutic for SCA6 and argue for the importance of early intervention for SCA6.
7
The categories of this paper are: ecology
25
The categories of this paper are: bioengineering
32
The categories of this paper are: zoology
24
The categories of this paper are: cancer
10
The categories of this paper are: and
11
The categories of this paper are: cognition
29
The categories of this paper are: education
5
The categories of this paper are: cell
27
The categories of this paper are: pathology
30
The categories of this paper are: scientific
31
The categories of this paper are: paleontology
19
The categories of this paper are: epidemiology
0
The categories of this paper are: genetics
14
The categories of this paper are: biophysics
6
The categories of this paper are: plant
16
The categories of this paper are: microbiology