Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Detection of Proteoglycan Loss from Articular Cartilage using Brillouin
  Microscopy, with Applications to Osteoarthritis   The degeneration of articular cartilage (AC) occurs in osteoarthritis (OA),
which is a leading cause of pain and disability in middle-aged and older
people. The early disease related changes in cartilage extra-cellular matrix
(ECM) start with depletion of proteoglycan(PG), leading to an increase in
tissue hydration and permeability. These early compositional changes are small
(<10%) and hence difficult to register with conventional non-invasive imaging
technologies (magnetic resonance and ultrasound imaging). Here we apply
Brillouin microscopy for detecting changes in the mechanical properties and
composition of porcine AC. OA-like degradation is mimicked by enzymatic tissue
digestion, and we compare Brillouin microscopy measurements against
histological staining of PG depletion over varying digestion times and enzyme
concentrations. The non-destructive nature of Brillouin imaging technology
opens new avenues for creating minimally invasive arthroscopic devices for OA
diagnostics and therapeutic monitoring.

22
The categories of this paper are: chao-dyn
36
The categories of this paper are: cmp-lg
13
The categories of this paper are: quant-ph
24
The categories of this paper are: dg-ga
11
The categories of this paper are: hep-lat
8
The categories of this paper are: hep-ex
28
The categories of this paper are: alg-geom
4
The categories of this paper are: cond-mat
20
The categories of this paper are: acc-phys
32
The categories of this paper are: atom-ph
30
The categories of this paper are: q-alg
26
The categories of this paper are: bayes-an
19
The categories of this paper are: eess
14
The categories of this paper are: math-ph
7
The categories of this paper are: hep-th
6
The categories of this paper are: astro-ph