Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Methylglyoxal Induces Endothelial Dysfunction via Stunning Elevated levels of methylglyoxal (MG) and its associated post-translational modifications have been reported to be associated with progression and development of numerous pathological conditions. Despite such extensive evidence, it still remains unclear what the specific effects of MG are other than that induction of cytotoxicity. Here we evaluated the effects of MG in cardiac endothelial cells in vitro. We found that MG leads to a non-proliferative state and endothelial dysfunction, which is reversible as MG-H1, a major post-translational modification induced by MG, is turned over by lysosomal degradation. MG-induced cellular stunning/paralysis describes a new hallmark for cellular dysfunction which could lead to alterations in tissue homeostasis as well as cell-to-cell interactions, thereby contributing to the pathogenesis of diseases.
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The categories of this paper are: evolutionary
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The categories of this paper are: communication
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The categories of this paper are: pathology
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The categories of this paper are: bioengineering
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The categories of this paper are: biochemistry
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The categories of this paper are: bioinformatics
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The categories of this paper are: molecular
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The categories of this paper are: physiology
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The categories of this paper are: systems
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The categories of this paper are: and
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The categories of this paper are: synthetic
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The categories of this paper are: developmental
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The categories of this paper are: cancer
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The categories of this paper are: toxicology
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The categories of this paper are: zoology
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The categories of this paper are: microbiology