Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Hypoxic Cell Waves around Necrotic Cores in Glioblastoma: A
  Biomathematical Model and its Therapeutic Implications   Glioblastoma is a rapidly evolving high-grade astrocytoma that is
distinguished pathologically from lower grade gliomas by the presence of
necrosis and microvascular hiperplasia. Necrotic areas are typically surrounded
by hypercellular regions known as "pseudopalisades" originated by local tumor
vessel occlusions that induce collective cellular migration events. This leads
to the formation of waves of tumor cells actively migrating away from central
hypoxia. We present a mathematical model that incorporates the interplay among
two tumor cell phenotypes, a necrotic core and the oxygen distribution. Our
simulations reveal the formation of a traveling wave of tumor cells that
reproduces the observed histologic patterns of pseudopalisades. Additional
simulations of the model equations show that preventing the collapse of tumor
microvessels leads to slower glioma invasion, a fact that might be exploited
for therapeutic purposes.

1
The categories of this paper are: cs
13
The categories of this paper are: quant-ph
28
The categories of this paper are: alg-geom
32
The categories of this paper are: atom-ph
8
The categories of this paper are: hep-ex
31
The categories of this paper are: ao-sci
25
The categories of this paper are: patt-sol
26
The categories of this paper are: bayes-an
0
The categories of this paper are: hep-ph
18
The categories of this paper are: econ
16
The categories of this paper are: stat
6
The categories of this paper are: astro-ph
30
The categories of this paper are: q-alg
9
The categories of this paper are: nlin
17
The categories of this paper are: q-fin
22
The categories of this paper are: chao-dyn