Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The Essential Role of Thermodynamics in metabolic network modeling:
  physical insights and computational challenges   Quantitative studies of cell metabolism are often based on large chemical
reaction network models. A steady state approach is suited to analyze phenomena
on the timescale of cell growth and circumvents the problem of incomplete
experimental knowledge on kinetic laws and parameters, but it shall be
supported by a correct implementation of thermodynamic constraints. In this
article we review the latter aspect highlighting its computational challenges
and physical insights. The simple introduction of Gibbs inequalities avoids the
presence of unfeasible loops allowing for correct timescale analysis but leads
to possibly non-convex feasible flux spaces, whose exploration needs efficient
algorithms. We shorty review on the implementation of thermodynamics through
variational principles in constraints based models of metabolic networks.

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The categories of this paper are: astro-ph
15
The categories of this paper are: nucl-ex
29
The categories of this paper are: funct-an
34
The categories of this paper are: chem-ph
9
The categories of this paper are: nlin
8
The categories of this paper are: hep-ex
32
The categories of this paper are: atom-ph
31
The categories of this paper are: ao-sci
30
The categories of this paper are: q-alg
22
The categories of this paper are: chao-dyn
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The categories of this paper are: gr-qc
7
The categories of this paper are: hep-th
2
The categories of this paper are: math
27
The categories of this paper are: comp-gas
18
The categories of this paper are: econ
25
The categories of this paper are: patt-sol