Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Effective dose fractionation schemes of radiotherapy for prostate cancer   Radiation therapy has remained as one of the main cancer treatment modalities
and a highly cost-effective single modality treatment of cancer care. Typical
regimens for fractionated external beam radiotherapy comprise a constant dose
administered on weekdays, and no radiation on weekends. However, every patient
has a tumor with distinct properties depending on intra-tumor heterogeneity,
aggressiveness, and interactive properties with other cells that may make it
more resistant or sensitive to radiation treatment. Accordingly, the concept of
personalized cancer treatment is emerging to specialize each patient treatment
case to the unique properties of the tumor. In this paper, we examine adaptive
radiation treatment strategies for heterogeneous tumors using a dynamical
system model that consists of radiation-resistant and parental cell populations
with unique interactive properties. We study different adaptive dosage
strategies for PC3 and DU145 prostate cancer cell lines. We show that stronger
doses of radiation given in longer time intervals, while keeping the overall
dosage the same, reduce final tumor volume by more than half in PC3 cell lines,
but by only five percent in DU145 cell lines. In addition, we tested an
adaptive dosing schedule by administering a stronger dosage on Friday to
compensate for the treatment-off period during the weekend, which was effective
in decreasing the final tumor volume of both cell lines. This result creates
interesting possibilities for new radiotherapy strategies at clinics that
cannot provide treatment on weekends. Finally, we propose a dosage plan
incorporating our findings.

9
The categories of this paper are: nlin
22
The categories of this paper are: chao-dyn
18
The categories of this paper are: econ
16
The categories of this paper are: stat
1
The categories of this paper are: cs
24
The categories of this paper are: dg-ga
23
The categories of this paper are: solv-int
0
The categories of this paper are: hep-ph
35
The categories of this paper are: mtrl-th
29
The categories of this paper are: funct-an
27
The categories of this paper are: comp-gas
31
The categories of this paper are: ao-sci
28
The categories of this paper are: alg-geom
25
The categories of this paper are: patt-sol
6
The categories of this paper are: astro-ph
8
The categories of this paper are: hep-ex