Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: P-value evaluation, variability index and biomarker categorization for
  adaptively weighted Fisher's meta-analysis method in omics applications   Meta-analysis methods have been widely used to combine results from multiple
clinical or genomic studies to increase statistical power and ensure robust and
accurate conclusion. Adaptively weighted Fisher's method (AW-Fisher) is an
effective approach to combine p-values from $K$ independent studies and to
provide better biological interpretation by characterizing which studies
contribute to meta-analysis. Currently, AW-Fisher suffers from lack of fast,
accurate p-value computation and variability estimate of AW weights. When the
number of studies $K$ is large, the $3^K - 1$ possible differential expression
pattern categories can become intractable. In this paper, we apply an
importance sampling technique with spline interpolation to increase accuracy
and speed of p-value calculation. Using resampling techniques, we propose a
variability index for the AW weight estimator and a co-membership matrix to
characterize pattern similarities between genes. The co-membership matrix is
further used to categorize differentially expressed genes based on their
meta-patterns for further biological investigation. The superior performance of
the proposed methods is shown in simulations. These methods are also applied to
two real applications to demonstrate intriguing biological findings.

29
The categories of this paper are: funct-an
4
The categories of this paper are: cond-mat
27
The categories of this paper are: comp-gas
3
The categories of this paper are: physics
34
The categories of this paper are: chem-ph
33
The categories of this paper are: plasm-ph
8
The categories of this paper are: hep-ex
23
The categories of this paper are: solv-int
36
The categories of this paper are: cmp-lg
2
The categories of this paper are: math
15
The categories of this paper are: nucl-ex
21
The categories of this paper are: adap-org
35
The categories of this paper are: mtrl-th
24
The categories of this paper are: dg-ga
7
The categories of this paper are: hep-th
37
The categories of this paper are: supr-con