Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans Age increases the risk for cognitive impairment and is the single major risk factor for Alzheimers disease (AD), the most prevalent form of dementia in the elderly. The pathophysiological processes triggered by aging that render the brain vulnerable to dementia involve, at least in part, changes in inflammatory mediators. Here we show that lipoxin A4 (LXA4), a lipid mediator of inflammation resolution known to stimulate endocannabinoid signaling in the brain, is reduced in the aging central nervous system. We demonstrate that genetic suppression of 5-lipoxygenase (5-LOX), the enzyme mediating LXA4 synthesis, promotes learning impairment in mice. Conversely, administration of exogenous LXA4 attenuated cytokine production and memory loss induced by inflammation in mice. We further show that cerebrospinal fluid LXA4 is reduced in patients with dementia and positively associates with memory performance, brain-derived neurotrophic factor (BDNF), and AD-linked amyloid-. Our findings suggest that reduced LXA4 levels may lead to vulnerability to age-related cognitive disorders and that promoting LXA4 signaling may comprise an effective strategy to prevent early cognitive decline in AD.
31
The categories of this paper are: paleontology
9
The categories of this paper are: synthetic
18
The categories of this paper are: systems
24
The categories of this paper are: cancer
8
The categories of this paper are: genomics
13
The categories of this paper are: animal
25
The categories of this paper are: bioengineering
2
The categories of this paper are: biology
30
The categories of this paper are: scientific
0
The categories of this paper are: genetics
7
The categories of this paper are: ecology
19
The categories of this paper are: epidemiology
28
The categories of this paper are: communication
22
The categories of this paper are: physiology
27
The categories of this paper are: pathology
32
The categories of this paper are: zoology