Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Spline Analysis of Biomarker Data Pooled From Multiple Matched/Nested
  Case-Control Studies   Pooling biomarker data across multiple studies enables researchers to get
more precise estimates of the association between biomarker exposure
measurements and disease risks due to increased sample sizes. However,
biomarker measurements vary significantly across different assays and
laboratories, and therefore calibration of the local laboratory measurements to
a reference laboratory is necessary before pooling data. We propose two methods
that can estimate a nonlinear relationship between biomarker exposure
measurements and disease risks using spline functions with a nested
case-control study design: full calibration and internalized calibration. The
full calibration method calibrates all observations using a study-specific
calibration model while the internalized calibration method only calibrates
observations that do not have reference laboratory measurements available. We
compare the two methods with a naive method whereby data are pooled without
calibration. We find that: (1) Internalized and full calibration methods have
substantially better performance than the naive method in terms of average
relative bias and coverage rate. (2) Full calibration is more robust than
internalized calibration when the size of calibration subsets varies. We apply
our methods to a pooling project with nested case-control study design to
estimate the association of circulating Vitamin D levels with the risk of
colorectal cancer.

1
The categories of this paper are: cs
11
The categories of this paper are: hep-lat
32
The categories of this paper are: atom-ph
29
The categories of this paper are: funct-an
3
The categories of this paper are: physics
15
The categories of this paper are: nucl-ex
14
The categories of this paper are: math-ph
2
The categories of this paper are: math
8
The categories of this paper are: hep-ex
24
The categories of this paper are: dg-ga
19
The categories of this paper are: eess
30
The categories of this paper are: q-alg
12
The categories of this paper are: nucl-th
0
The categories of this paper are: hep-ph
37
The categories of this paper are: supr-con
27
The categories of this paper are: comp-gas