Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Optogenetic control of intracellular flows and cell migration: a
  comprehensive mathematical analysis with a minimal active gel model   The actin cytoskeleton of cells is in continuous motion due to both
polymerization of new filaments and their contraction by myosin II molecular
motors. Through adhesion to the substrate, such intracellular flow can be
converted into cell migration. Recently, optogenetics has emerged as a new
powerful experimental method to control both actin polymerization and myosin II
contraction. While optogenetic control of polymerization can initiate cell
migration by generating protrusion, it is less clear if and how optogenetic
control of contraction can also affect cell migration. Here we analyze the
latter situation using a minimal variant of active gel theory into which we
include optogenetic activation as a spatiotemporally constrained perturbation.
The model can describe the symmetrical flow of the actomyosin system observed
in optogenetic experiments, but not the long-lasting polarization required for
cell migration. Motile solutions become possible if cytoskeletal polymerization
is included through the boundary conditions. Optogenetic activation of
contraction can then initiate locomotion in a symmetrically spreading cell and
strengthen motility in an asymmetrically polymerizing one. If designed
appropriately, it can also arrest motility even for protrusive boundaries.

15
The categories of this paper are: nucl-ex
2
The categories of this paper are: math
5
The categories of this paper are: gr-qc
33
The categories of this paper are: plasm-ph
3
The categories of this paper are: physics
37
The categories of this paper are: supr-con
17
The categories of this paper are: q-fin
0
The categories of this paper are: hep-ph
9
The categories of this paper are: nlin
35
The categories of this paper are: mtrl-th
31
The categories of this paper are: ao-sci
11
The categories of this paper are: hep-lat
20
The categories of this paper are: acc-phys
14
The categories of this paper are: math-ph
30
The categories of this paper are: q-alg
12
The categories of this paper are: nucl-th