Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Impact of receptor-ligand distance on adhesion cluster stability   Cells in multicellular organisms adhere to the extracellular matrix through
two-dimensional clusters spanning a size range from very few to thousands of
adhesion bonds. For many common receptor-ligand systems, the ligands are
tethered to a surface via polymeric spacers with finite binding range, thus
adhesion cluster stability crucially depends on receptor-ligand distance. We
introduce a one-step master equation which incorporates the effect of
cooperative binding through a finite number of polymeric ligand tethers. We
also derive Fokker-Planck and mean field equations as continuum limits of the
master equation. Polymers are modeled either as harmonic springs or as
worm-like chains. In both cases, we find bistability between bound and unbound
states for intermediate values of receptor-ligand distance and calculate the
corresponding switching times. For small cluster sizes, stochastic effects
destabilize the clusters at large separation, as shown by a detailed analysis
of the stochastic potential resulting from the Fokker-Planck equation.

17
The categories of this paper are: q-fin
29
The categories of this paper are: funct-an
27
The categories of this paper are: comp-gas
8
The categories of this paper are: hep-ex
14
The categories of this paper are: math-ph
34
The categories of this paper are: chem-ph
9
The categories of this paper are: nlin
24
The categories of this paper are: dg-ga
37
The categories of this paper are: supr-con
1
The categories of this paper are: cs
30
The categories of this paper are: q-alg
21
The categories of this paper are: adap-org
16
The categories of this paper are: stat
25
The categories of this paper are: patt-sol
20
The categories of this paper are: acc-phys
31
The categories of this paper are: ao-sci