Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Evolution of quantitative trait locus hotspots in yeast species Dissecting the genetic basis of complex trait remains a real challenge. The budding yeast Saccharomyces cerevisiae has become a model organism for studying quantitative traits, successfully increasing our knowledge in many aspects. However, the exploration of the genotype-phenotype relationship in non-model yeast species could provide a deeper insight into the genetic basis of complex traits. Here, we have studied this relationship in the Lachancea waltii species which diverged from the S. cerevisiae lineage prior to the whole-genome duplication. By performing linkage mapping analyses in this species, we identified 86 quantitative trait loci (QTL) affecting growth fitness in a large number of conditions. The distribution of these loci across the genome has revealed two major QTL hotspots. A first hotspot corresponds to a general fitness QTL, impacting a wide range of conditions. By contrast, the second hotspot highlighted a fitness trade-off with a disadvantageous allele for drug-free conditions which proved to be advantageous in the presence of several drugs. Finally, the comparison of the detected QTL in L. waltii with those which had been previously identified for the same traits in a closely related species, Lachancea kluyveri, clearly revealed the absence of interspecific conservation of these loci. Altogether, our results expand our knowledge on the variation of the QTL landscape across different yeast species.
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The categories of this paper are: biology
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The categories of this paper are: toxicology
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The categories of this paper are: synthetic
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The categories of this paper are: microbiology
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The categories of this paper are: cognition
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The categories of this paper are: animal
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The categories of this paper are: neuroscience
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The categories of this paper are: systems
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The categories of this paper are: and
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The categories of this paper are: immunology
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The categories of this paper are: education
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The categories of this paper are: physiology
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The categories of this paper are: zoology
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The categories of this paper are: cancer
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The categories of this paper are: paleontology
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The categories of this paper are: developmental