Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Young and Undamaged rMSA Improves the Longevity of Mice Improvement of longevity is an eternal dream of human beings. Here we report that a single protein recombinant mouse serum albumin (rMSA) improved the lifespan and healthspan of C57BL/6N mice. The median lifespan extensions were 17.6% for female and 20.3% for male, respectively. The grip strength of rMSA-treated female and male mice increased by 29.6% and 17.4%, respectively. Meanwhile, the percentage of successful escape increased 23.0% in rMSA-treated male mice using the Barnes Maze test. The rMSA used in this study is young and almost undamaged. We define the concept "young and undamaged" to any protein without any unnecessary modifications by four parameters: intact free thiol (if any), no advanced glycation end-product, no carbonylation, and no homocysteinylation. Here "young and undamaged" rMSA is much younger and less damaged than the endogenous serum albumin from young mice at 1.5 months of age. We predict that young and undamaged proteins altogether can further improve the longevity.
32
The categories of this paper are: zoology
25
The categories of this paper are: bioengineering
29
The categories of this paper are: education
13
The categories of this paper are: animal
24
The categories of this paper are: cancer
27
The categories of this paper are: pathology
3
The categories of this paper are: evolutionary
4
The categories of this paper are: neuroscience
6
The categories of this paper are: plant
10
The categories of this paper are: and
18
The categories of this paper are: systems
30
The categories of this paper are: scientific
28
The categories of this paper are: communication
8
The categories of this paper are: genomics
5
The categories of this paper are: cell
20
The categories of this paper are: pharmacology