Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Binding of the immunomodulatory drug Bz-423 to mitochondrial FoF1-ATP
  synthase in living cells by FRET acceptor photobleaching   Bz-423 is a promising new drug for treatment of autoimmune diseases. This
small molecule binds to subunit OSCP of the mitochondrial enzyme FoF1-ATP
synthase and modulates its catalytic activities. We investigate the binding of
Bz-423 to mitochondria in living cells and how subunit rotation in FoF1-ATP
synthase, i.e. the mechanochemical mechanism of this enzyme, is affected by
Bz-423. Therefore, the enzyme was marked selectively by genetic fusion with the
fluorescent protein EGFP to the C terminus of subunit gamma. Imaging the
threedimensional arrangement of mitochondria in living yeast cells was possible
at superresolution using structured illumination microscopy, SIM. We measured
uptake and binding of a Cy5-labeled Bz-423 derivative to mitochondrial FoF1-ATP
synthase in living yeast cells using FRET acceptor photobleaching microscopy.
Our data confirmed the binding of Cy5-labeled Bz-423 to the top of the F1
domain of the enzyme in mitochondria of living Saccharomyces cerevisiae cells.

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The categories of this paper are: physics
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The categories of this paper are: dg-ga
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The categories of this paper are: econ
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The categories of this paper are: quant-ph
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The categories of this paper are: gr-qc
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The categories of this paper are: q-alg
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The categories of this paper are: stat
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The categories of this paper are: cond-mat
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The categories of this paper are: eess
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The categories of this paper are: cmp-lg
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The categories of this paper are: nucl-ex
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The categories of this paper are: q-fin
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The categories of this paper are: hep-lat
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The categories of this paper are: nucl-th
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The categories of this paper are: acc-phys
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The categories of this paper are: alg-geom