Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: Variability in SARS-Cov-2 IgG Antibody Affinity To Omicron and Delta Variants in Convalescent and Community mRNA Vaccinated Individuals The emergence of Omicron and Delta variants of SARS-CoV-2 has begun a number of discussions regarding breakthrough infection, waning immunity, need and timing for vaccine boosters and whether existing mRNA vaccines for the wildtype strain are adequate. Our work leverages a biosensor-based technique to evaluate the binding efficacy of SARS-CoV-2 S1 specific salivary antibodies to the Omicron and Delta variants using a cohort of mRNA vaccinated (n=109) and convalescent (n=19) subjects. We discovered a wide range of binding efficacies to the variant strains, with a mean reduction of 60.5%, 26.7%, and 14.7% in measurable signal to the Omicron strain and 13.4%, 2.4%, and -6.4% percent mean reduction to the Delta Variant for convalescent, Pfizer, and Moderna vaccinated groups respectively. This assay may be an important tool in determining susceptibility to infection or need for booster immunization as the pandemic evolves.

Key PointsO_LIAMPERIAL assay developed to quantify salivary SARS-CoV-2 S1 IgG antibodies to Omicron and Delta variants
C_LIO_LIThere was a reduction in affinity to both Delta and Omicron Variants
C_LIO_LIThe reduction in affinity was more pronounced to Omicron than for Delta Variants
C_LIO_LIThere was a significant difference between IgG affinities in Individuals vaccinated with Pfizer versus Moderna Vaccines
C_LI
7
The categories of this paper are: emergency
68
The categories of this paper are: surgery
33
The categories of this paper are: physical
51
The categories of this paper are: education
27
The categories of this paper are: quality
41
The categories of this paper are: nephrology
26
The categories of this paper are: systems
8
The categories of this paper are: epidemiology
66
The categories of this paper are: dentistry
52
The categories of this paper are: nursing
53
The categories of this paper are: pathology
58
The categories of this paper are: hematology
63
The categories of this paper are: pain
12
The categories of this paper are: genomic
17
The categories of this paper are: informatics
29
The categories of this paper are: anesthesia