Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Noise Processing by MicroRNA-Mediated Circuits: the Incoherent
  Feed-Forward Loop, Revisited   The intrinsic stochasticity of gene expression is usually mitigated in higher
eukaryotes by post-transcriptional regulation channels that stabilise the
output layer, most notably protein levels. The discovery of small non-coding
RNAs (miRNAs) in specific motifs of the genetic regulatory network has led to
identifying noise buffering as the possible key function they exert in
regulation. Recent in vitro} and in silico studies have corroborated this
hypothesis. It is however also known that miRNA-mediated noise reduction is
hampered by transcriptional bursting in simple topologies. Here, using
stochastic simulations validated by analytical calculations based on van
Kampen's expansion, we revisit the noise-buffering capacity of the
miRNA-mediated Incoherent Feed Forward Loop (IFFL), a small module that is
widespread in the gene regulatory networks of higher eukaryotes, in order to
account for the effects of intermittency in the transcriptional activity of the
modulator gene. We show that bursting considerably alters the circuit's ability
to control static protein noise. By comparing with other regulatory
architectures, we find that direct transcriptional regulation significantly
outperforms the IFFL in a broad range of kinetic parameters. This suggests
that, under pulsatile inputs, static noise reduction may be less important than
dynamical aspects of noise and information processing in characterising the
performance of regulatory elements.

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The categories of this paper are: stat
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The categories of this paper are: hep-ph
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The categories of this paper are: chao-dyn
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The categories of this paper are: solv-int
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The categories of this paper are: econ
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The categories of this paper are: acc-phys
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The categories of this paper are: math-ph
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The categories of this paper are: q-alg
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The categories of this paper are: plasm-ph
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The categories of this paper are: quant-ph
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The categories of this paper are: atom-ph
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The categories of this paper are: gr-qc
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The categories of this paper are: eess
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The categories of this paper are: mtrl-th
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The categories of this paper are: comp-gas
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The categories of this paper are: nucl-th