Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Numerical evidence for nucleated self-assembly of DNA brick structures   The observation by Ke et al. [Science 338, 1177 (2012)] that large numbers of
short, pre-designed DNA strands can assemble into three-dimensional target
structures came as a great surprise, as no colloidal self-assembling system has
ever achieved the same degree of complexity. That failure seemed easy to
rationalise: the larger the number of distinct building blocks, the higher the
expected error rate for self-assembly. The experiments of Ke et al. have
disproved this argument. Here, we report Monte Carlo simulations of the
self-assembly of a DNA brick cube, comprising approximately 1000 types of DNA
strand, using a simple model. We model the DNA strands as lattice tetrahedra
with attractive patches, the interaction strengths of which are computed using
a standard thermodynamic model. We find that, within a narrow temperature
window, the target structure assembles with high probability. Our simulations
suggest that mis-assembly is disfavoured because of a slow nucleation step. As
our model incorporates no aspect of DNA other than its binding properties,
these simulations suggest that, with proper design of the building blocks,
other systems, such as colloids, may also assemble into truly complex
structures.

8
The categories of this paper are: hep-ex
16
The categories of this paper are: stat
10
The categories of this paper are: q-bio
35
The categories of this paper are: mtrl-th
28
The categories of this paper are: alg-geom
24
The categories of this paper are: dg-ga
21
The categories of this paper are: adap-org
26
The categories of this paper are: bayes-an
19
The categories of this paper are: eess
17
The categories of this paper are: q-fin
11
The categories of this paper are: hep-lat
20
The categories of this paper are: acc-phys
29
The categories of this paper are: funct-an
30
The categories of this paper are: q-alg
12
The categories of this paper are: nucl-th
0
The categories of this paper are: hep-ph