Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells The collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in the study of morphogenesis, tissue engineering, and cancer. Different mechanisms are at play, including, cell-cell adhesion, cell motility, and proliferation. However, the relative importance of each one is elusive. Here, experiments with a culture of glioblastoma multiforme cells on a substrate are combined with in silico modeling to infer the rate of each mechanism. By parametrizing these rates, the time-dependence of the spatial correlation observed experimentally is reproduced. The obtained results suggest a reduction in cell-cell adhesion with the density of cells. The reason for such reduction and possible implications for the collective dynamics of cancer cells are discussed.
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The categories of this paper are: plant
1
The categories of this paper are: bioinformatics
8
The categories of this paper are: genomics
22
The categories of this paper are: physiology
29
The categories of this paper are: education
7
The categories of this paper are: ecology
30
The categories of this paper are: scientific
12
The categories of this paper are: behavior
9
The categories of this paper are: synthetic
19
The categories of this paper are: epidemiology
31
The categories of this paper are: paleontology
18
The categories of this paper are: systems
27
The categories of this paper are: pathology
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The categories of this paper are: microbiology
20
The categories of this paper are: pharmacology
23
The categories of this paper are: immunology