Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin   The lifetimes of non-covalent A:a knob-hole bonds in fibrin probed with the
optical trap-based force-clamp first increases ("catch bonds") and then
decreases ("slip bonds") with increasing tensile force. Molecular modeling of
"catch-to-slip" transition using the atomic structure of the A:a complex
reveals that the movable flap serves as tension-dependent molecular switch.
Flap dissociation from the regulatory B-domain in $\gamma$-nodule and
translocation from the periphery to knob `A' triggers the hole `a' closure and
interface remodeling, which results in the increased binding affinity and
prolonged bond lifetimes. Fluctuating bottleneck theory is developed to
understand the "catch-to-slip" transition in terms of the interface stiffness
$\kappa =$ 15.7 pN nm $^{-1}$, interface size fluctuations 0.7-2.7 nm, knob `A'
escape rate constant $k_0 =$ 0.11 nm$^2$ s$^{-1}$, and transition distance for
dissociation $\sigma_y =$ 0.25 nm. Strengthening of the A:a knob-hole bonds
under small tension might favor formation and reinforcement of nascent fibrin
clots under hydrodynamic shear.

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The categories of this paper are: mtrl-th
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The categories of this paper are: patt-sol
16
The categories of this paper are: stat
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The categories of this paper are: plasm-ph
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The categories of this paper are: math-ph
20
The categories of this paper are: acc-phys
5
The categories of this paper are: gr-qc
8
The categories of this paper are: hep-ex
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The categories of this paper are: dg-ga
9
The categories of this paper are: nlin
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The categories of this paper are: adap-org
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The categories of this paper are: funct-an
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The categories of this paper are: cs
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The categories of this paper are: solv-int
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The categories of this paper are: atom-ph
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The categories of this paper are: hep-lat