Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's Ataxia Disruptions to iron-sulfur (Fe-S) clusters, essential cofactors for a broad range of proteins, cause widespread cellular defects resulting in human disease. An underappreciated source of damage to Fe-S clusters are cuprous (Cu1+) ions. Since histone H3 enzymatically produces Cu1+ to support copper-dependent functions, we asked whether this activity could become detrimental to Fe-S clusters. Here, we report that histone H3-mediated Cu1+ toxicity is a major determinant of cellular Fe-S cluster quotient. Inadequate Fe-S cluster supply, either due to diminished assembly as occurs in Friedreichs Ataxia or defective distribution, causes severe metabolic and growth defects in S. cerevisiae. Decreasing Cu1+ abundance, through attenuation of histone cupric reductase activity or depletion of total cellular copper, restored Fe-S cluster-dependent metabolism and growth. Our findings reveal a novel interplay between chromatin and mitochondria in Fe-S cluster homeostasis, and a potential pathogenic role for histone enzyme activity and Cu1+ in diseases with Fe-S cluster dysfunction.

TeaserReduction of Cu1+ production by histone H3 restores cellular deficiencies caused by insufficient supply of iron-sulfur clusters.
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The categories of this paper are: evolutionary
19
The categories of this paper are: epidemiology
1
The categories of this paper are: bioinformatics
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The categories of this paper are: ecology
32
The categories of this paper are: zoology
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The categories of this paper are: behavior
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The categories of this paper are: genetics
11
The categories of this paper are: cognition
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The categories of this paper are: neuroscience
22
The categories of this paper are: physiology
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The categories of this paper are: synthetic
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The categories of this paper are: biochemistry
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The categories of this paper are: biophysics
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The categories of this paper are: communication
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The categories of this paper are: genomics
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The categories of this paper are: cell