Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Multi-scale simulation of thrombus formation at LVAD inlet cannula
  connection: Importance of Virchow's triad   As pump thrombosis is reduced in current-generation ventricular assist
devices (VAD), adverse events such as bleeding or stroke remain at unacceptable
rates. Thrombosis around the VAD inlet cannula (IC) has been highlighted as a
possible source of stroke events. Recent computational fluid dynamics (CFD)
studies have attempted to characterize the thrombosis risk of different
IC-ventricle configurations. However, purely CFD simulations relate thrombosis
risk to ad-hoc criteria based on flow characteristics, with little
consideration of biochemical factors. This study investigates the genesis of IC
thrombosis including two elements of the Virchow's triad: Endothelial injury
and Hypercoagulability. To this end a multi-scale thrombosis simulation that
includes platelet activity and coagulation reactions was performed. Our results
show significant thrombin formation in stagnation regions (|u|< 0.002 m/s)
close to the IC wall. In addition, high shear-mediated platelet activation was
observed over the leading-edge tip of the cannula which mirrors the thrombus
deposition pattern observed clinically. The current study reveals the
importance of biochemical factors to the genesis of thrombosis at the
ventricular-cannula junction which can inform clinical decisions in terms of
anticoagulation/antiplatelet therapy and guide engineers to develop more robust
designs.

33
The categories of this paper are: plasm-ph
30
The categories of this paper are: q-alg
31
The categories of this paper are: ao-sci
25
The categories of this paper are: patt-sol
6
The categories of this paper are: astro-ph
4
The categories of this paper are: cond-mat
32
The categories of this paper are: atom-ph
27
The categories of this paper are: comp-gas
3
The categories of this paper are: physics
12
The categories of this paper are: nucl-th
0
The categories of this paper are: hep-ph
24
The categories of this paper are: dg-ga
13
The categories of this paper are: quant-ph
9
The categories of this paper are: nlin
18
The categories of this paper are: econ
15
The categories of this paper are: nucl-ex