Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A fluid-structure instability driven physiomarker for aneurysm growth   Currently, the diagnosis and treatment of an aneurysm are informed by
correlative guidelines on its size and growth rate, along with a holistic
consideration of associated symptoms and pathologies. However, aneurysms can
exhibit significant growth or rupture before these criteria are met;
conversely, large aneurysms may exceed intervention criteria but remain stable
over time. Without methods to evaluate the key factors driving aneurysm
development, it is difficult to assign preventative treatment to patients most
in need. In this work, we propose a fluid-structure instability that may cause
blood vessels to dilate and form aneurysms, or induce existing aneurysms to
grow significantly. The ab-initio framework yields a stability parameter that
describes the onset of this "fluttering" of the aortic wall, which may drive or
signal the presence of abnormal aortic growth. A retrospective study was
conducted with 4D flow MRI data from 117 patients indicated for cardiac imaging
and 100 normal subjects recruited prospectively as healthy volunteers. Both
cohorts comprised subjects with magnetic resonance imaging (MRI) scans of the
full thoracic aorta. The stability parameter was calculated for every subject
from the earliest MRI data. For a 72 patient subcohort with at least one
follow-up imaging exam after the initial MRI scan, the growth of each patient's
aneurysm was forecast by the stability parameter and compared to the maximum
growth rate observed in follow-up as well as any subsequent surgical
intervention. A receiving operator characteristic (ROC) curve was used to gauge
the stability parameter as a potential diagnostic physiomarker. The area under
the curve of the ROC analysis was 0.97. The proposed flutter type instability
appears to offer accurate prediction of aneurysm development from patient
specific data that can inform precise, targeted management of disease
progression.

29
The categories of this paper are: funct-an
30
The categories of this paper are: q-alg
14
The categories of this paper are: math-ph
18
The categories of this paper are: econ
6
The categories of this paper are: astro-ph
1
The categories of this paper are: cs
26
The categories of this paper are: bayes-an
4
The categories of this paper are: cond-mat
7
The categories of this paper are: hep-th
25
The categories of this paper are: patt-sol
17
The categories of this paper are: q-fin
0
The categories of this paper are: hep-ph
34
The categories of this paper are: chem-ph
32
The categories of this paper are: atom-ph
31
The categories of this paper are: ao-sci
13
The categories of this paper are: quant-ph