Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Interactions between natural selection and recombination shape the genomic landscape of introgression Hybridization between lineages that have not reached complete reproductive isolation appears more and more like a common phenomenon. Indeed, speciation genomics studies have now extensively shown that many species genomes have hybrid ancestry. However, genomic patterns of introgression are often heterogeneous across the genome. In many organisms, a positive correlation between introgression levels and recombination rate has been observed. It is usually explained by the purging of deleterious introgressed material due to incompatibilities. However, the opposite relationship was observed in a North American population of Drosophila melanogaster with admixed European and African ancestry. In order to explore how directional and epistatic selection can impact the relationship between introgression and recombination, we performed forward simulations of whole D. melanogaster genomes reflecting the North American populations history. Our results revealed that the simplest models of positive selection often yield negative correlations between introgression and recombination such as the one observed in D. melanogaster. We also confirmed that incompatibilities tend to produce positive introgression-recombination correlations. And yet, we identify parameter space under each model where the predicted correlation is reversed. These findings deepen our understanding of the evolutionary forces that may shape patterns of ancestry across genomes, and they strengthen the foundation for future studies aimed at estimating genome-wide parameters of selection in admixed populations.
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The categories of this paper are: cell
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The categories of this paper are: paleontology
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The categories of this paper are: bioengineering
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The categories of this paper are: systems
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The categories of this paper are: behavior
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The categories of this paper are: genomics
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The categories of this paper are: pharmacology
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The categories of this paper are: and
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The categories of this paper are: microbiology
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The categories of this paper are: pathology
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The categories of this paper are: physiology
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The categories of this paper are: bioinformatics
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The categories of this paper are: education
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The categories of this paper are: plant
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The categories of this paper are: cancer
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The categories of this paper are: synthetic