Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Mechanisms of B cell Synapse Formation Predicted by Stochastic
  Simulation   The clustering of B cell receptor (BCR) molecules and the formation of the
protein segregation structure known as the immunological synapse appears to
precede antigen (Ag) uptake by B cells. The mature B cell synapse is
characterized by a central cluster of BCR/Ag molecular complexes surrounded by
a ring of LFA-1/ICAM-1 complexes. Recent experimental evidence shows receptor
clustering in B cells can occur via mechanical or signaling-driven processes.
An alternative mechanism of diffusion and affinity-dependent binding has been
proposed to explain synapse formation in the absence of signaling-driven
processes. In this work, we investigated the biophysical mechanisms that drive
immunological synapse formation in B cells across the physiological range of
BCR affinity (KA~10^6-10^10 M-1) through computational modeling. Our
computational approach is based on stochastic simulation of diffusion and
reaction events with a clearly defined mapping between probabilistic parameters
of our model and their physical equivalents. We show that a
diffusion-and-binding mechanism is sufficient to drive synapse formation only
at low BCR affinity and for a relatively stiff B cell membrane that undergoes
little deformation. We thus predict the need for alternative mechanisms: a
difference in the mechanical properties of BCR/Ag and LFA-1/ICAM-1 bonds and/or
signaling driven processes.

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The categories of this paper are: astro-ph
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The categories of this paper are: atom-ph
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The categories of this paper are: econ
2
The categories of this paper are: math
34
The categories of this paper are: chem-ph
36
The categories of this paper are: cmp-lg
25
The categories of this paper are: patt-sol
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The categories of this paper are: hep-ex
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The categories of this paper are: quant-ph
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The categories of this paper are: hep-th
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The categories of this paper are: gr-qc
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The categories of this paper are: alg-geom
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The categories of this paper are: funct-an
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The categories of this paper are: dg-ga
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The categories of this paper are: q-fin
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The categories of this paper are: mtrl-th