Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Sex-dependent effects of traumatic stress on social behavior and neuronal activation in the prefrontal cortex and amygdala Social behavior is complex and fundamental, and deficits in social behavior are common pathological features for a variety of psychiatric disorders including anxiety, depression, and posttraumatic stress disorder. Acute stress has a negative impact on social behavior, and these effects may vary based on sex. The aim of this study was to explore the effect of footshock stress on the sociability of male and female C57Bl/6J mice. Animals were divided into two main groups of footshock exposure or context exposure control. Each group had mice that were treated with either the benzodiazepine alprazolam, or vehicle. Neuronal activation during social interaction was assessed using immunohistochemistry against the immediate early gene product cFos. Footshock stress induced a significantly increased latency to approach a social interaction counterpart in both sexes. Stress-induced increases in defensive tail-rattling behavior elicited during the sociability test were sex-dependent and alleviated by alprazolam. Alprazolam also lowered social exploration and neuronal activation in the infralimbic medial prefrontal cortex. Social interaction induced sex-dependent differences in cFos activation in the lateral subdivision of the central nucleus of the amygdala and ventromedial intercalated cell clusters. Overall, our results suggest that acute footshock stress induces alterations in sociability and patterns of cFos activation in a sex-dependent manner.
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The categories of this paper are: pathology
10
The categories of this paper are: and
8
The categories of this paper are: genomics
26
The categories of this paper are: biochemistry
31
The categories of this paper are: paleontology
13
The categories of this paper are: animal
24
The categories of this paper are: cancer
32
The categories of this paper are: zoology
5
The categories of this paper are: cell
21
The categories of this paper are: toxicology
2
The categories of this paper are: biology
28
The categories of this paper are: communication
18
The categories of this paper are: systems
29
The categories of this paper are: education
6
The categories of this paper are: plant
14
The categories of this paper are: biophysics