Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Tip-enhanced Raman spectroscopic detection of aptamers   Single molecule detection, sequencing and conformational mapping of aptamers
are important for improving medical and biosensing technologies and for better
understanding of biological processes at the molecular level. We obtain
vibrational signals of single aptamers immobilized on gold substrates using
tip-enhanced Raman spectroscopy (TERS). We compare topographic and optical
signals and investigate the fluctuations of the position-dependent TERS
spectra. TERS mapping provides information about the chemical composition and
conformation of aptamers, and paves the way to future single-molecule
label-free sequencing.

29
The categories of this paper are: funct-an
0
The categories of this paper are: hep-ph
16
The categories of this paper are: stat
6
The categories of this paper are: astro-ph
26
The categories of this paper are: bayes-an
13
The categories of this paper are: quant-ph
24
The categories of this paper are: dg-ga
22
The categories of this paper are: chao-dyn
17
The categories of this paper are: q-fin
5
The categories of this paper are: gr-qc
9
The categories of this paper are: nlin
11
The categories of this paper are: hep-lat
25
The categories of this paper are: patt-sol
31
The categories of this paper are: ao-sci
19
The categories of this paper are: eess
27
The categories of this paper are: comp-gas