Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Actin remodelling controls proteasome homeostasis upon stress When cells are stressed, bulk translation is often downregulated to reduce energy demands whilst stress-response proteins are simultaneously upregulated. 19S Regulatory Particle Assembly-Chaperones (RPACs) are selectively translated upon TORC1 inhibition to promote proteasome assembly and activity, maintaining cell viability. However, the molecular mechanism for such selective translational upregulation is unclear. Using yeast, we discover that remodelling of the actin cytoskeleton is important for RPAC translation following TORC1 inhibition. mRNA of the RPAC ADC17 travels along actin cables and is enriched at cortical actin patches under stress, dependent upon the early endocytic protein Ede1. ede1{Delta} cells failed to induce RPACs and proteasome assembly upon TORC1 inhibition. Conversely, artificially tethering ADC17 mRNA to cortical actin patches enhanced its translation upon stress. These findings suggest that actin dense structures such as cortical actin patches may serve as a translation platform for a subset of stress-induced mRNAs including regulators of proteasome homeostasis.
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The categories of this paper are: synthetic
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The categories of this paper are: molecular
6
The categories of this paper are: plant
4
The categories of this paper are: neuroscience
31
The categories of this paper are: paleontology
18
The categories of this paper are: systems
8
The categories of this paper are: genomics
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The categories of this paper are: biophysics
32
The categories of this paper are: zoology
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The categories of this paper are: genetics
21
The categories of this paper are: toxicology
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The categories of this paper are: animal
3
The categories of this paper are: evolutionary
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The categories of this paper are: communication
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The categories of this paper are: microbiology
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The categories of this paper are: and