Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: HDfleX: Software for flexible high structural resolution of hydrogen/deuterium-exchange mass spectrometry data Hydrogen/deuterium-exchange mass spectrometry (HDX-MS) experiments on protein structures can be performed at three levels: (1) by enzymatically digesting labelled proteins and analyzing the peptides (bottom-up), (2) by further fragmenting peptides following digestion (middle-down), and (3) by fragmenting the intact labelled protein (top-down), using soft gas-phase fragmentation methods, such as electron transfer dissociation (ETD). However, to the best of our knowledge, the software packages currently available for the analysis of HDX-MS data do not enable the peptide- and ETD-levels to be combined - they can only be analyzed separately. Thus, we developed HDfleX - a standalone application for the analysis of flexible high structural resolution of HDX-MS data, which allows data at any level of structural resolution (intact protein, peptide, fragment) to be merged. HDfleX features rapid experimental data fitting, robust statistical significance analyses and optional methods for theoretical intrinsic calculations and a novel empirical correction for comparison between solution conditions.
31
The categories of this paper are: paleontology
9
The categories of this paper are: synthetic
10
The categories of this paper are: and
13
The categories of this paper are: animal
20
The categories of this paper are: pharmacology
28
The categories of this paper are: communication
2
The categories of this paper are: biology
16
The categories of this paper are: microbiology
3
The categories of this paper are: evolutionary
1
The categories of this paper are: bioinformatics
15
The categories of this paper are: developmental
4
The categories of this paper are: neuroscience
30
The categories of this paper are: scientific
27
The categories of this paper are: pathology
32
The categories of this paper are: zoology
11
The categories of this paper are: cognition