Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Temporal signals drive the emergence of multicellular information
  networks   Coordinated responses to environmental stimuli are critical for multicellular
organisms. To overcome the obstacles of cell-to-cell heterogeneity and noisy
signaling dynamics within individual cells, cells must effectively exchange
information with peers. However, the dynamics and mechanisms of collective
information transfer driven by external signals is poorly understood. Here we
investigate the calcium dynamics of neuronal cells that form confluent
monolayers and respond to cyclic ATP stimuli in microfluidic devices. Using
Granger inference to reconstruct the underlying causal relations between the
cells, we find that the cells self-organize into spatially decentralized and
temporally stationary networks to support information transfer via gap junction
channels. The connectivity of the causal networks depend on the temporal
profile of the external stimuli, where short periods, or long periods with
small duty fractions, lead to reduced connectivity and fractured network
topology. We build a theoretical model based on communicating excitable units
that reproduces our observations. The model further predicts that connectivity
of the causal network is maximal at an optimal communication strength, which is
confirmed by the experiments. Together, our results show that information
transfer between neuronal cells is externally regulated by the temporal profile
of the stimuli, and internally regulated by cell-cell communication.

20
The categories of this paper are: acc-phys
28
The categories of this paper are: alg-geom
25
The categories of this paper are: patt-sol
21
The categories of this paper are: adap-org
14
The categories of this paper are: math-ph
11
The categories of this paper are: hep-lat
6
The categories of this paper are: astro-ph
24
The categories of this paper are: dg-ga
7
The categories of this paper are: hep-th
27
The categories of this paper are: comp-gas
12
The categories of this paper are: nucl-th
2
The categories of this paper are: math
32
The categories of this paper are: atom-ph
17
The categories of this paper are: q-fin
5
The categories of this paper are: gr-qc
30
The categories of this paper are: q-alg