Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Evaluation of sex differences in laser-induced choroidal neovascularization severity, phenotype and disease progression Age-related macular degeneration (AMD) progresses through two phases: a non-exudative "dry" stage that compromises vision but does not involve angiogenesis, and an angiogenic "wet" phase characterized by choroidal neovascularization (CNV), in which neovessels from the choroid break through the Bruchs membrane to form neovascular lesions in the macula. If left untreated, CNV leads to permanent central blindness, which the current standard of care (anti-VEGF therapy) arrests but does not reverse. In laser-induced CNV, a laser is used to rupture the Bruchs membrane, prompting the outgrowth of choroidal blood vessels in a wound healing response. This model was used to develop currently available CNV therapeutics, such as intravitreal injection of anti-VEGF and corticosteroid therapies and is considered a gold standard model for CNV. Laser-induced CNV thus remains a highly clinically relevant model of CNV secondary to AMD and other pathologies, such as myopia. A rapidly growing body of research suggests that the pathogenesis of myriad diseases is highly dependent on biological sex, yet most studies use only male animals. This highlights the importance of determining whether the severity and pathogenesis of commonly used models of disease, for example laser-induced CNV, differ between sexes. In the present study, we tracked longitudinal progression and pathogenesis of laser-induced CNV in male and female animals, and found that CNV severity did not differ between sexes. This lack of difference recapitulates findings in human patients with CNV, which have also identified that both sexes are at equal risk of CNV development in the contexts of both age-related macular degeneration induced CNV and myopic CNV.
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The categories of this paper are: developmental
27
The categories of this paper are: pathology
31
The categories of this paper are: paleontology
25
The categories of this paper are: bioengineering
21
The categories of this paper are: toxicology
6
The categories of this paper are: plant
22
The categories of this paper are: physiology
30
The categories of this paper are: scientific
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The categories of this paper are: systems
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The categories of this paper are: and
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The categories of this paper are: ecology
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The categories of this paper are: communication
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The categories of this paper are: biophysics
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The categories of this paper are: neuroscience
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The categories of this paper are: evolutionary
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The categories of this paper are: behavior