Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: CD8+ T cell signature in acute SARS-CoV-2 infection identifies memory precursors Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated and enhanced immune response upon re-infection with the same pathogen1,2. Since the outbreak of the ongoing coronavirus disease 19 (COVID-19) pandemic, a key question has focused on whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells stimulated during acute infection give rise to long-lived memory T cells3. Using spectral flow cytometry combined with cellular indexing of transcriptomes and T cell receptor (TCR) sequencing we longitudinally characterize individual SARS-CoV-2-specific CD8+ T cells of COVID-19 patients from acute infection to one year into recovery and find a distinct signature identifying long-lived memory CD8+ T cells. SARS-CoV-2-specific memory CD8+ T cells persisting one year after acute infection re-express CD45RA and interleukin-7 receptor  (CD127), upregulate T cell factor-1 (TCF1), and maintain low CCR7, thus resembling CD45RA+ effector-memory T (TEMRA) cells. Tracking individual clones of SARS-CoV-2-specific CD8+ T cells, we reveal that an interferon signature marks clones giving rise to long-lived cells, whereas prolonged proliferation and mammalian target of rapamycin (mTOR) signaling are associated with clone contraction and disappearance. Collectively, we identify a transcriptional signature differentiating short-from long-lived memory CD8+ T cells following an acute virus infection in humans.
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The categories of this paper are: neuroscience
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The categories of this paper are: zoology
0
The categories of this paper are: genetics
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The categories of this paper are: biophysics
1
The categories of this paper are: bioinformatics
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The categories of this paper are: behavior
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The categories of this paper are: microbiology
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The categories of this paper are: education
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The categories of this paper are: paleontology
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The categories of this paper are: scientific
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The categories of this paper are: and
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The categories of this paper are: genomics
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The categories of this paper are: evolutionary
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The categories of this paper are: epidemiology
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The categories of this paper are: toxicology
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The categories of this paper are: ecology