Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla During early embryogenesis in amniotic vertebrates, the gonads differentiate into either ovaries or testes. The first cell lineage to differentiate gives rise to the supporting cells; Sertoli cells in males and pre-granulosa cells in females. These key cell types direct the differentiation of the other cell types in the gonad, including steroidogenic cells. The gonadal surface epithelium and the interstitial cell populations are less well studied, and little is known about their sexual differentiation programs. Here, we show the requirement of the transcription factor gene TGIF1 for ovarian development in the chicken embryo. TGIF1 is expressed in the two principal ovarian somatic cell populations, the cortex and the pre-granulosa cells of the medulla. TGIF1 expression is associated with an ovarian phenotype in sex reversal experiments. In addition, targeted over-expression and gene knockdown experiments indicate that TGIF1 is required for proper ovarian cortical formation. TGIF1 is identified as the first known regulator of juxtacortical medulla formation. These findings provide new insights into chicken ovarian differentiation and development, specifically in the process of cortical and juxtacortical medulla formation, a poorly understood area.

SUMMARY STATEMENTThe transcription factor TGIF1 is required for proper ovarian sex differentiation in chicken embryos, regulating development of the cortical and juxtacortical medulla, independently of the supporting cell sex lineage.
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The categories of this paper are: scientific
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The categories of this paper are: bioengineering
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The categories of this paper are: immunology
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The categories of this paper are: ecology
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The categories of this paper are: systems
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The categories of this paper are: behavior
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The categories of this paper are: zoology
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The categories of this paper are: genetics
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The categories of this paper are: biophysics
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The categories of this paper are: animal
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The categories of this paper are: cancer
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The categories of this paper are: molecular
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The categories of this paper are: cell
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The categories of this paper are: pharmacology
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The categories of this paper are: communication
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The categories of this paper are: and