Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins The nonstructural NS1 protein is a virulence factor secreted by dengue virus (DENV)-infected cells. NS1 is known to alter the complement system, activate immune cells and perturb endothelial barriers. Here we show that pro-inflammatory signals are triggered by a high affinity complex formed between NS1 and human high-density lipoproteins (HDL). Electron microscopy images of the NS1-HDL complexes show spherical HDL particles with rod-shaped NS1 protrusions on their surface. These complexes are readily detectable in the plasma of hospitalized dengue patients using anti-apolipoprotein A-I (ApoA-I) antibodies specific of the HDL moiety. The functional reprogramming of HDL particles by the NS1 protein as a means to exacerbate systemic inflammation during DENV infection provides a new paradigm linking the human lipoprotein network to dengue pathogenesis.
21
The categories of this paper are: toxicology
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The categories of this paper are: epidemiology
32
The categories of this paper are: zoology
2
The categories of this paper are: biology
24
The categories of this paper are: cancer
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The categories of this paper are: animal
20
The categories of this paper are: pharmacology
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The categories of this paper are: scientific
4
The categories of this paper are: neuroscience
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The categories of this paper are: molecular
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The categories of this paper are: communication
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The categories of this paper are: systems
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The categories of this paper are: developmental
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The categories of this paper are: ecology
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The categories of this paper are: genetics
23
The categories of this paper are: immunology