Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Gene expression noise accelerates the evolution of a biological
  oscillator   Gene expression is a biochemical process, where stochastic binding and
un-binding events naturally generate fluctuations and cell-to-cell variability
in gene dynamics. These fluctuations typically have destructive consequences
for proper biological dynamics and function (e.g., loss of timing and synchrony
in biological oscillators). Here, we show that gene expression noise
counter-intuitively accelerates the evolution of a biological oscillator and,
thus, can impart a benefit to living organisms. We used computer simulations to
evolve two mechanistic models of a biological oscillator at different levels of
gene expression noise. We first show that gene expression noise induces
oscillatory-like dynamics in regions of parameter space that cannot oscillate
in the absence of noise. We then demonstrate that these noise-induced
oscillations generate a fitness landscape whose gradient robustly and quickly
guides evolution by mutation towards robust and self-sustaining oscillation.
These results suggest that noise can help dynamical systems evolve or learn new
behavior by revealing cryptic dynamic phenotypes outside the bifurcation point.

13
The categories of this paper are: quant-ph
6
The categories of this paper are: astro-ph
25
The categories of this paper are: patt-sol
3
The categories of this paper are: physics
17
The categories of this paper are: q-fin
22
The categories of this paper are: chao-dyn
27
The categories of this paper are: comp-gas
19
The categories of this paper are: eess
16
The categories of this paper are: stat
20
The categories of this paper are: acc-phys
26
The categories of this paper are: bayes-an
21
The categories of this paper are: adap-org
7
The categories of this paper are: hep-th
31
The categories of this paper are: ao-sci
34
The categories of this paper are: chem-ph
12
The categories of this paper are: nucl-th