Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Clonal selection and therapy resistance in acute leukemias: Mathematical
  modelling explains different proliferation patterns at diagnosis and relapse   Recent experimental evidence suggests that acute myeloid leukemias may
originate from multiple clones of malignant cells. Nevertheless it is not known
how the observed clones may differ with respect to cell properties such as
proliferation and self-renewal. There are scarcely any data on how these cell
properties change due to chemotherapy and relapse. We propose a new
mathematical model to investigate the impact of cell properties on multi-clonal
composition of leukemias. Model results imply that enhanced self-renewal may be
a key mechanism in the clonal selection process. Simulations suggest that fast
proliferating and highly self-renewing cells dominate at primary diagnosis
while relapse following therapy-induced remission is triggered mostly by highly
self-renewing but slowly proliferating cells. Comparison of simulation results
to patient data demonstrates that the proposed model is consistent with
clinically observed dynamics based on a clonal selection process.

13
The categories of this paper are: quant-ph
6
The categories of this paper are: astro-ph
34
The categories of this paper are: chem-ph
19
The categories of this paper are: eess
11
The categories of this paper are: hep-lat
5
The categories of this paper are: gr-qc
28
The categories of this paper are: alg-geom
17
The categories of this paper are: q-fin
15
The categories of this paper are: nucl-ex
24
The categories of this paper are: dg-ga
0
The categories of this paper are: hep-ph
16
The categories of this paper are: stat
27
The categories of this paper are: comp-gas
31
The categories of this paper are: ao-sci
36
The categories of this paper are: cmp-lg
32
The categories of this paper are: atom-ph