Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Time-varying $\ell_0$ optimization for Spike Inference from Multi-Trial
  Calcium Recordings   Optical imaging of genetically encoded calcium indicators is a powerful tool
to record the activity of a large number of neurons simultaneously over a long
period of time from freely behaving animals. However, determining the exact
time at which a neuron spikes and estimating the underlying firing rate from
calcium fluorescence data remains challenging, especially for calcium imaging
data obtained from a longitudinal study. We propose a multi-trial time-varying
$\ell_0$ penalized method to jointly detect spikes and estimate firing rates by
robustly integrating evolving neural dynamics across trials. Our simulation
study shows that the proposed method performs well in both spike detection and
firing rate estimation. We demonstrate the usefulness of our method on calcium
fluorescence trace data from two studies, with the first study showing
differential firing rate functions between two behaviors and the second study
showing evolving firing rate function across trials due to learning.

31
The categories of this paper are: ao-sci
2
The categories of this paper are: math
12
The categories of this paper are: nucl-th
30
The categories of this paper are: q-alg
10
The categories of this paper are: q-bio
21
The categories of this paper are: adap-org
24
The categories of this paper are: dg-ga
7
The categories of this paper are: hep-th
0
The categories of this paper are: hep-ph
28
The categories of this paper are: alg-geom
8
The categories of this paper are: hep-ex
25
The categories of this paper are: patt-sol
13
The categories of this paper are: quant-ph
18
The categories of this paper are: econ
22
The categories of this paper are: chao-dyn
4
The categories of this paper are: cond-mat