Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization Soluble adenylyl cyclase (sAC: ADCY10) is essential for activating dormant sperm. Studies of freshly dissected mouse sperm identified sAC as needed for initiating capacitation and activating motility. We now use an improved sAC inhibitor, TDI-10229, for a comprehensive analysis of sAC function in human sperm. Unlike dissected mouse sperm, human sperm are collected post-ejaculation, after sAC activity has already been stimulated. Even in ejaculated human sperm, TDI-10229 interrupts stimulated motility and capacitation, and it prevents acrosome reaction in capacitated sperm. At present, there are no non-hormonal, pharmacological methods for contraception. Because sAC activity is required post-ejaculation at multiple points during the sperms journey to fertilize the oocyte, sAC inhibitors define candidates for non-hormonal, on-demand contraceptives suitable for delivery via intravaginal devices in females.
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The categories of this paper are: bioinformatics
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The categories of this paper are: education
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The categories of this paper are: evolutionary
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The categories of this paper are: zoology
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The categories of this paper are: molecular
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The categories of this paper are: synthetic
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The categories of this paper are: plant
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The categories of this paper are: developmental
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The categories of this paper are: systems
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The categories of this paper are: biophysics
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The categories of this paper are: cell
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The categories of this paper are: physiology
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The categories of this paper are: scientific
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The categories of this paper are: immunology
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The categories of this paper are: epidemiology
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The categories of this paper are: ecology