Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Cytoskeletal regulation of a transcription factor by DNA mimicry A long-established strategy for transcription regulation is the tethering of transcription factors to cellular membranes. In contrast, the principal effectors of Hedgehog signaling, the Gli transcription factors, are regulated by microtubules in the primary cilium and the cytoplasm. How Gli is tethered to microtubules remains unclear. We uncover DNA mimicry by the ciliary kinesin Kif7 as a mechanism for the recruitment of Gli to microtubules, revealing a new mode of tethering a DNA-binding protein to the cytoskeleton. Gli increases the Kif7-microtubule affinity and consequently modulates the localization of both proteins to microtubules and the cilium tip. Thus, the kinesin-microtubule system is not a passive Gli tether but a regulatable platform tuned by the kinesin-transcription factor interaction. We re-tooled the unique DNA-mimicry-based Gli-Kif7 interaction for inhibiting the nuclear and cilium localization of Gli. This strategy can be potentially exploited for downregulating erroneously activated Gli in human cancers.
18
The categories of this paper are: systems
13
The categories of this paper are: animal
11
The categories of this paper are: cognition
8
The categories of this paper are: genomics
1
The categories of this paper are: bioinformatics
12
The categories of this paper are: behavior
30
The categories of this paper are: scientific
22
The categories of this paper are: physiology
10
The categories of this paper are: and
28
The categories of this paper are: communication
6
The categories of this paper are: plant
26
The categories of this paper are: biochemistry
14
The categories of this paper are: biophysics
29
The categories of this paper are: education
9
The categories of this paper are: synthetic
31
The categories of this paper are: paleontology