Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The electrophysiology of the betacell based on single transmembrane
  protein characteristics   The electrophysiology of betacells is at the origin of insulin secretion.
Betacells exhibit a complex behaviour upon stimulation with glucose including
repeated and uninterrupted bursting. Mathematical modelling is most suitable to
improve knowledge about the function of various transmembrane currents provided
the model is based on reliable data. This is the first attempt to build a
mathematical model for the betacell-electrophysiology in a bottom-up approach
which relies on single protein conductivity data. The results of previous
whole-cell-based models are reconsidered. The full simulation including all
prominent transmembrane proteins in betacells is used to provide a functional
interpretation of their role in betacell-bursting and an updated vantage point
of betacell-electrophysiology. As a result of a number of in silico knock-out-
and block-experiments the novel model makes some unexpected predictions:
Single-channel conductivity data imply that calcium-gated potassium currents
are rather small. Thus, their role in burst interruption has to be revisited.
An alternative role in high calcium level oscillations is proposed and an
alternative burst interruption model is presented. It also turns out that
sodium currents are more relevant than expected so far. Experiments are
proposed to verify these predictions.

33
The categories of this paper are: plasm-ph
23
The categories of this paper are: solv-int
22
The categories of this paper are: chao-dyn
11
The categories of this paper are: hep-lat
35
The categories of this paper are: mtrl-th
4
The categories of this paper are: cond-mat
8
The categories of this paper are: hep-ex
0
The categories of this paper are: hep-ph
37
The categories of this paper are: supr-con
1
The categories of this paper are: cs
36
The categories of this paper are: cmp-lg
20
The categories of this paper are: acc-phys
9
The categories of this paper are: nlin
28
The categories of this paper are: alg-geom
7
The categories of this paper are: hep-th
21
The categories of this paper are: adap-org