Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Investigation of multiple-dynein transport of melanosomes by
  non-invasive force measurement using fluctuation unit $\chi$   Pigment organelles known as melanosomes disperse or aggregate in a
melanophore in response to hormones. These movements are mediated by the
microtubule motors kinesin-2 and cytoplasmic dynein. However, the force
generation mechanism of dynein, unlike that of kinesin, is not well understood.
In this study, to address this issue, we investigated the dynein-mediated
aggregation of melanosomes in zebrafish melanophores. We applied the
fluctuation theorem of non-equilibrium statistical mechanics to estimate forces
acting on melanosomes during transport by dynein, given that the energy of a
system is related to its fluctuation. Our results demonstrate that multiple
force-producing units cooperatively transport a single melanosome. Since the
force is generated by dynein, this suggests that multiple dyneins carry a
single melanosome. Cooperative transport has been reported for other
organelles; thus, multiple-motor transport may be a universal mechanism for
moving organelles within the cell.

34
The categories of this paper are: chem-ph
31
The categories of this paper are: ao-sci
29
The categories of this paper are: funct-an
37
The categories of this paper are: supr-con
19
The categories of this paper are: eess
8
The categories of this paper are: hep-ex
9
The categories of this paper are: nlin
23
The categories of this paper are: solv-int
20
The categories of this paper are: acc-phys
2
The categories of this paper are: math
22
The categories of this paper are: chao-dyn
26
The categories of this paper are: bayes-an
32
The categories of this paper are: atom-ph
36
The categories of this paper are: cmp-lg
18
The categories of this paper are: econ
6
The categories of this paper are: astro-ph