Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: The relationship between autoantibodies targeting GPCRs and the renin-angiotensin system associates with COVID-19 severity The coronavirus disease 2019 (COVID-19) can evolve to clinical manifestations resembling systemic autoimmune diseases, with the presence of autoantibodies that are still poorly characterized. To address this issue, we performed a cross-sectional study of 246 individuals to determine whether autoantibodies targeting G protein-coupled receptors (GPCRs) and renin-angiotensin system (RAS)-related molecules were associated with COVID-19-related clinical outcomes. Moderate and severe patients exhibited the highest autoantibody levels, relative to both healthy controls and patients with mild COVID-19 symptoms. Random Forest, a machine learning model, ranked anti-GPCR autoantibodies targeting downstream molecules in the RAS signaling pathway such as the angiotensin II type 1 and Mas receptor, and the chemokine receptor CXCR3 as the three strongest predictors of severe disease. Moreover, while the autoantibody network signatures were relatively conserved in patients with mild COVID-19 compared to healthy controls, they were disrupted in moderate and most perturbed in severe patients. Our data indicate that the relationship between autoantibodies targeting GPCRs and RAS-related molecules associates with the clinical severity of COVID-19, suggesting novel molecular pathways for therapeutic interventions.
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The categories of this paper are: health
38
The categories of this paper are: hiv
62
The categories of this paper are: orthopedics
14
The categories of this paper are: cardiovascular
25
The categories of this paper are: improvement
36
The categories of this paper are: economics
20
The categories of this paper are: psychiatry
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The categories of this paper are: and
47
The categories of this paper are: care
71
The categories of this paper are: ethics
59
The categories of this paper are: respiratory
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The categories of this paper are: medicine
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The categories of this paper are: global
52
The categories of this paper are: nursing
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The categories of this paper are: otolaryngology
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The categories of this paper are: genetic