Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: An Open Quantum Systems approach to proton tunnelling in DNA   One of the most important topics in molecular biology is the genetic
stability of DNA. One threat to this stability is proton transfer along the
hydrogen bonds of DNA that could lead to tautomerisation, hence creating point
mutations. We present a theoretical analysis of the hydrogen bonds between the
Guanine-Cytosine (G-C) nucleotide, which includes an accurate model of the
structure of the base pairs, the quantum dynamics of the hydrogen bond proton,
and the influence of the decoherent and dissipative cellular environment. We
determine that the quantum tunnelling contribution to the process is several
orders of magnitude larger than the contribution from classical
over-the-barrier hopping. Due to this significant quantum contribution, we find
that the canonical and tautomeric forms of G-C inter-convert over timescales
far shorter than biological ones and hence thermal equilibrium is rapidly
reached. Furthermore, we find a large tautomeric occupation probability of
$1.73\times 10^{-4}$, suggesting that such proton transfer may well play a far
more important role in DNA mutation than has hitherto been suggested. Our
results could have far-reaching consequences for current models of genetic
mutations.

1
The categories of this paper are: cs
33
The categories of this paper are: plasm-ph
18
The categories of this paper are: econ
32
The categories of this paper are: atom-ph
25
The categories of this paper are: patt-sol
14
The categories of this paper are: math-ph
19
The categories of this paper are: eess
23
The categories of this paper are: solv-int
0
The categories of this paper are: hep-ph
12
The categories of this paper are: nucl-th
28
The categories of this paper are: alg-geom
35
The categories of this paper are: mtrl-th
31
The categories of this paper are: ao-sci
5
The categories of this paper are: gr-qc
21
The categories of this paper are: adap-org
7
The categories of this paper are: hep-th