Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli Antibiotic treatment kills a large portion of a population, while a small, tolerant subpopulation survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a population gains antibiotic resistance, a growing health concern. We examined how E. coli transcriptional networks changed in response to lethal ampicillin concentrations. We are the first to apply transcriptional regulatory network (TRN) analysis to antibiotic tolerance by leveraging existing knowledge and our transcriptional data. TRN analysis shows that gene expression changes specific to ampicillin treatment are likely caused by specific sigma and transcription factors typically regulated by proteolysis. These results demonstrate that to survive lethal concentration of ampicillin specific regulatory proteins change activity and cause a coordinated transcriptional response that leverages multiple gene systems.
23
The categories of this paper are: immunology
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The categories of this paper are: developmental
12
The categories of this paper are: behavior
3
The categories of this paper are: evolutionary
25
The categories of this paper are: bioengineering
4
The categories of this paper are: neuroscience
32
The categories of this paper are: zoology
8
The categories of this paper are: genomics
16
The categories of this paper are: microbiology
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The categories of this paper are: communication
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The categories of this paper are: and
9
The categories of this paper are: synthetic
31
The categories of this paper are: paleontology
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The categories of this paper are: pharmacology
5
The categories of this paper are: cell
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The categories of this paper are: cancer