Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: An adaptively weighted statistic for detecting differential gene
  expression when combining multiple transcriptomic studies   Global expression analyses using microarray technologies are becoming more
common in genomic research, therefore, new statistical challenges associated
with combining information from multiple studies must be addressed. In this
paper we will describe our proposal for an adaptively weighted (AW) statistic
to combine multiple genomic studies for detecting differentially expressed
genes. We will also present our results from comparisons of our proposed AW
statistic to Fisher's equally weighted (EW), Tippett's minimum p-value (minP)
and Pearson's (PR) statistics. Due to the absence of a uniformly powerful test,
we used a simplified Gaussian scenario to compare the four methods. Our AW
statistic consistently produced the best or near-best power for a range of
alternative hypotheses. AW-obtained weights also have the additional advantage
of filtering discordant biomarkers and providing natural detected gene
categories for further biological investigation. Here we will demonstrate the
superior performance of our proposed AW statistic based on a mix of power
analyses, simulations and applications using data sets for multi-tissue energy
metabolism mouse, multi-lab prostate cancer and lung cancer.

1
The categories of this paper are: cs
34
The categories of this paper are: chem-ph
12
The categories of this paper are: nucl-th
37
The categories of this paper are: supr-con
11
The categories of this paper are: hep-lat
20
The categories of this paper are: acc-phys
35
The categories of this paper are: mtrl-th
28
The categories of this paper are: alg-geom
0
The categories of this paper are: hep-ph
23
The categories of this paper are: solv-int
21
The categories of this paper are: adap-org
30
The categories of this paper are: q-alg
17
The categories of this paper are: q-fin
18
The categories of this paper are: econ
36
The categories of this paper are: cmp-lg
32
The categories of this paper are: atom-ph