Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Biological Tissue Imaging with a Position and Time Sensitive Pixelated
  Detector   We demonstrate the capabilities of a highly parallel, active pixel detector
for large-area, mass spectrometric imaging of biological tissue sections. A
bare Timepix assembly (512x512 pixels) is combined with chevron microchannel
plates on an ion microscope matrix-assisted laser desorption time-of-flight
mass spectrometer (MALDI TOF-MS). The detector assembly registers position- and
time-resolved images of multiple m/z species in every measurement frame. We
prove the applicability of the detection system to bio-molecular mass
spectrometry imaging on biologically relevant samples by mass-resolved images
from Timepix measurements of a peptide-grid benchmark sample and mouse testis
tissue slices. Mass-spectral and localization information of analytes at
physiological concentrations are measured in MALDI-TOF-MS imaging experiments.
We show a high spatial resolution (pixel size down to 740x740 nm2 on the sample
surface) and a spatial resolving power of 6 {\mu}m with a microscope mode laser
field of view of 100-335 {\mu}m. Automated, large-area imaging is demonstrated
and the Timepix' potential for fast, large-area image acquisition is
highlighted.

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The categories of this paper are: math
30
The categories of this paper are: q-alg
25
The categories of this paper are: patt-sol
12
The categories of this paper are: nucl-th
29
The categories of this paper are: funct-an
8
The categories of this paper are: hep-ex
1
The categories of this paper are: cs
20
The categories of this paper are: acc-phys
24
The categories of this paper are: dg-ga
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The categories of this paper are: bayes-an
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The categories of this paper are: cond-mat
16
The categories of this paper are: stat
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The categories of this paper are: plasm-ph
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The categories of this paper are: nucl-ex
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The categories of this paper are: q-bio
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The categories of this paper are: astro-ph