Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Quantitative prediction of conditional vulnerabilities in regulatory and metabolic networks of Mycobacterium tuberculosis The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological states, underlies its success in evading the immune system and tolerating antibiotic killing. Drug tolerant phenotypes are a major reason why the tuberculosis (TB) mortality rate is so high, with over 1.8 million deaths annually. To develop new TB therapeutics that better treat the infection (faster and more completely), a systems-level approach is needed to reveal the complexity of network-based adaptations of Mtb. Here, we report a new predictive model called PRIME (Phenotype of Regulatory influences Integrated with Metabolism and Environment) to uncover environment-specific vulnerabilities within the regulatory and metabolic networks of Mtb. Through extensive performance evaluations using genome-wide fitness screens, we demonstrate that PRIME makes mechanistically accurate predictions of context-specific vulnerabilities within the integrated regulatory and metabolic networks of Mtb, accurately rank-ordering targets for potentiating treatment with frontline drugs.
7
The categories of this paper are: ecology
4
The categories of this paper are: neuroscience
10
The categories of this paper are: and
20
The categories of this paper are: pharmacology
13
The categories of this paper are: animal
21
The categories of this paper are: toxicology
31
The categories of this paper are: paleontology
29
The categories of this paper are: education
24
The categories of this paper are: cancer
6
The categories of this paper are: plant
16
The categories of this paper are: microbiology
15
The categories of this paper are: developmental
9
The categories of this paper are: synthetic
25
The categories of this paper are: bioengineering
3
The categories of this paper are: evolutionary
22
The categories of this paper are: physiology