Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Metabolic and functional connectivity provide unique and complementary insights into cognition-connectome relationships A major challenge in current cognitive neuroscience is how functional brain connectivity gives rise to human cognition. Functional magnetic resonance imaging (fMRI) describes brain connectivity based on cerebral oxygenation dynamics (hemodynamic connectivity), whereas [18 F]-fluorodeoxyglucose functional positron emission tomography (FDG-fPET) describes brain connectivity based on cerebral glucose uptake (metabolic connectivity), each providing a unique characterisation of the human brain. How these two modalities differ in their contribution to cognition and behaviour is unclear. We used simultaneous resting-state FDG-fPET/fMRI to investigate how hemodynamic connectivity and metabolic connectivity relate to cognitive function by applying partial least squares analyses. Results revealed that while for both modalities the frontoparietal anatomical subdivisions related the strongest to cognition, using hemodynamic measures this network expressed executive functioning, episodic memory, and depression, while for metabolic measures this network exclusively expressed executive functioning. These findings demonstrate the unique advantages that simultaneous FDG-PET/fMRI has to provide a comprehensive understanding of the neural mechanisms that underpin cognition and highlights the importance of multimodality imaging in cognitive neuroscience research.
17
The categories of this paper are: molecular
16
The categories of this paper are: microbiology
8
The categories of this paper are: genomics
9
The categories of this paper are: synthetic
13
The categories of this paper are: animal
21
The categories of this paper are: toxicology
11
The categories of this paper are: cognition
31
The categories of this paper are: paleontology
32
The categories of this paper are: zoology
1
The categories of this paper are: bioinformatics
29
The categories of this paper are: education
7
The categories of this paper are: ecology
15
The categories of this paper are: developmental
19
The categories of this paper are: epidemiology
6
The categories of this paper are: plant
30
The categories of this paper are: scientific