Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Local tissue effects and peri-implant bone healing induced by implant
  surface treatment: an in vivo study in the sheep   Objective: The aim of this study was to assess, through biological analysis,
the local effects and osseointegration of dental implants incorporating surface
micro/nanofeatures compared to implants of identical design without surface
treatment. Background: Known to impact bone cell behavior, surface chemical and
topography modifications target improved osseointegration and long-term success
of dental implants. Very few studies assess the performance of implants
presenting both micro-and nanofeatures in vivo on the animal models used in
preclinical studies for medical device certification. Methods: Implant surfaces
were characterized in terms of topography and surface chemical composition.
After 4 weeks and 13 weeks of implantation in sheep femoral condyles, forty
implants were evaluated through micro-computed tomography, histopathologic, and
histomorphometric analyses. Results: No local adverse effects were observed
around implants. Histomorphometric analyses showed significantly higher
bone-to-implant contact in the coronal region of the surface treated implant at
week 4 and week 13, respectively 79.3$\pm$11.2% and 86.4$\pm$6.7%, compared to
the untreated implant's 68.3$\pm$8.8% and 74.8$\pm$13%. Micro-computed
tomography analyses revealed that healing patterns differed between coronal and
apical regions, with higher coronal boneto-implant contact at week 13.
Histopathologic results showed, at week 13, bone healing around the surface
treated implant with undistinguishable defect margins while the untreated
implant still presented bone condensation and traces of the initial drill
defect. Conclusion: Our results suggest that the surface treated implant not
only shows no deleterious effects on local tissues but also promotes faster
bone healing around the implant. (word count: 241

6
The categories of this paper are: astro-ph
8
The categories of this paper are: hep-ex
17
The categories of this paper are: q-fin
31
The categories of this paper are: ao-sci
26
The categories of this paper are: bayes-an
0
The categories of this paper are: hep-ph
9
The categories of this paper are: nlin
27
The categories of this paper are: comp-gas
7
The categories of this paper are: hep-th
30
The categories of this paper are: q-alg
34
The categories of this paper are: chem-ph
23
The categories of this paper are: solv-int
22
The categories of this paper are: chao-dyn
33
The categories of this paper are: plasm-ph
29
The categories of this paper are: funct-an
12
The categories of this paper are: nucl-th