Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Supervised prediction of aging-related genes from a context-specific
  protein interaction subnetwork   Background. Human aging is linked to many prevalent diseases. The aging
process is highly influenced by genetic factors. Hence, it is important to
identify human aging-related genes. We focus on supervised prediction of such
genes. Gene expression-based methods for this purpose study genes in isolation
from each other. While protein-protein interaction (PPI) network-based methods
for this purpose account for interactions between genes' protein products,
current PPI network data are context-unspecific, spanning different biological
conditions. Instead, here, we focus on an aging-specific subnetwork of the
entire PPI network, obtained by integrating aging-specific gene expression data
and PPI network data. The potential of such data integration has been
recognized but mostly in the context of cancer. So, we are the first to propose
a supervised learning framework for predicting aging-related genes from an
aging-specific PPI subnetwork.
  Results. In a systematic and comprehensive evaluation, we find that in many
of the evaluation tests: (i) using an aging-specific subnetwork indeed yields
more accurate aging-related gene predictions than using the entire network, and
(ii) predictive methods from our framework that have not previously been used
for supervised prediction of aging-related genes outperform existing prominent
methods for the same purpose.
  Conclusion. These results justify the need for our framework.

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The categories of this paper are: quant-ph
30
The categories of this paper are: q-alg
20
The categories of this paper are: acc-phys
23
The categories of this paper are: solv-int
6
The categories of this paper are: astro-ph
9
The categories of this paper are: nlin
17
The categories of this paper are: q-fin
32
The categories of this paper are: atom-ph
16
The categories of this paper are: stat
14
The categories of this paper are: math-ph
18
The categories of this paper are: econ
35
The categories of this paper are: mtrl-th
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The categories of this paper are: dg-ga
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The categories of this paper are: hep-lat
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The categories of this paper are: alg-geom
8
The categories of this paper are: hep-ex