Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Inferring epistasis from genomic data with comparable mutation and
  outcrossing rate   We consider a population evolving due to mutation, selection and
recombination, where selection includes single-locus terms (additive fitness)
and two-loci terms (pairwise epistatic fitness). We further consider the
problem of inferring fitness in the evolutionary dynamics from one or several
snap-shots of the distribution of genotypes in the population. In the recent
literature this has been done by applying the Quasi-Linkage Equilibrium (QLE)
regime first obtained by Kimura in the limit of high recombination. Here we
show that the approach also works in the interesting regime where the effects
of mutations are comparable to or larger than recombination. This leads to a
modified main epistatic fitness inference formula where the rates of mutation
and recombination occur together. We also derive this formula using by a
previously developed Gaussian closure that formally remains valid when
recombination is absent. The findings are validated through numerical
simulations.

15
The categories of this paper are: nucl-ex
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The categories of this paper are: astro-ph
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The categories of this paper are: nlin
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The categories of this paper are: econ
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The categories of this paper are: stat
7
The categories of this paper are: hep-th
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The categories of this paper are: mtrl-th
13
The categories of this paper are: quant-ph
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The categories of this paper are: q-fin
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The categories of this paper are: comp-gas
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The categories of this paper are: nucl-th
20
The categories of this paper are: acc-phys
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The categories of this paper are: physics
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The categories of this paper are: funct-an
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The categories of this paper are: hep-ex
2
The categories of this paper are: math