Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: On biological flow networks: Antagonism between hydrodynamic and
  metabolic stimuli as driver of topological transitions   A plethora of computational models have been developed in recent decades to
account for the morphogenesis of complex biological fluid networks, such as
capillary beds. Contemporary adaptation models are based on optimization
schemes where networks react and adapt toward given flow patterns. Doing so, a
system reduces dissipation and network volume, thereby altering its final form.
Yet, recent numeric studies on network morphogenesis, incorporating uptake of
metabolites by the embedding tissue, have indicated the conventional approach
to be insufficient. Here, we systematically study a hybrid-model which combines
the network adaptation schemes intended to generate space-filling perfusion as
well as optimal filtration of metabolites. As a result, we find hydrodynamic
stimuli (wall-shear stress) and filtration based stimuli (uptake of
metabolites) to be antagonistic as hydrodynamically optimized systems have
suboptimal uptake qualities and vice versa. We show that a switch between
different optimization regimes is typically accompanied with a complex
transition between topologically redundant meshes and spanning trees. Depending
on the metabolite demand and uptake capabilities of the adaptating networks, we
are further able to demonstrate the existence of nullity re-entrant behavior
and the development of compromised phenotypes such as dangling non-perfused
vessels and bottlenecks.

28
The categories of this paper are: alg-geom
36
The categories of this paper are: cmp-lg
21
The categories of this paper are: adap-org
25
The categories of this paper are: patt-sol
34
The categories of this paper are: chem-ph
7
The categories of this paper are: hep-th
17
The categories of this paper are: q-fin
31
The categories of this paper are: ao-sci
15
The categories of this paper are: nucl-ex
32
The categories of this paper are: atom-ph
24
The categories of this paper are: dg-ga
6
The categories of this paper are: astro-ph
4
The categories of this paper are: cond-mat
1
The categories of this paper are: cs
16
The categories of this paper are: stat
22
The categories of this paper are: chao-dyn