Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Kinetics of fragmentation and dissociation of two-strand protein
  filaments: Coarse-grained simulations and experiments   While a significant body of investigations have been focused on the process
of protein self-assembly, much less is understood about the reverse process of
a filament breaking due to thermal motion into smaller fragments, or
depolymerization of subunits from the filament ends. Indirect evidence for
actin and amyloid filament fragmentation has been reported, although the
phenomenon has never been directly observed either experimentally or in
simulations. Here we report the direct observation of filament depolymerization
and breakup in a minimal, calibrated model of coarse-grained molecular
simulation. We quantify the orders of magnitude by which the depolymerization
rate from the filament ends $k_\mathrm{off}$ is larger than fragmentation rate
$k_{-}$ and establish the law $k_\mathrm{off}/k_- = \exp [( \varepsilon_\| -
\varepsilon_\bot) / k_\mathrm{B}T ] = \exp [0.5 \varepsilon / k_\mathrm{B}T ]$,
which accounts for the topology and energy of bonds holding the filament
together. This mechanism and the order-of-magnitude predictions are well
supported by direct experimental measurements of depolymerization of insulin
amyloid filaments.

32
The categories of this paper are: atom-ph
22
The categories of this paper are: chao-dyn
6
The categories of this paper are: astro-ph
7
The categories of this paper are: hep-th
31
The categories of this paper are: ao-sci
26
The categories of this paper are: bayes-an
27
The categories of this paper are: comp-gas
23
The categories of this paper are: solv-int
1
The categories of this paper are: cs
18
The categories of this paper are: econ
24
The categories of this paper are: dg-ga
2
The categories of this paper are: math
8
The categories of this paper are: hep-ex
9
The categories of this paper are: nlin
17
The categories of this paper are: q-fin
12
The categories of this paper are: nucl-th