Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to significant public health, economic and social problems. Development of effective vaccines is still a priority to contain the virus and end the global pandemic. In this study, we reported that ReCOV, a recombinant trimeric NTD and RBD two-component SARS-CoV-2 subunit vaccine adjuvanted with BFA03 (an AS03-like squalene adjuvant), induced high levels of neutralizing antibodies against SARS-CoV-2 and the circulating variants in mice, rabbits and rhesus macaques. Notably, two-dose immunizations of ReCOV provided complete protection against challenge with SARS-CoV-2 in hACE2 transgenic mice and rhesus macaques, without observable antibody-dependent enhancement of infection. These results support further clinical development of ReCOV and the vaccine is currently being evaluated in a phase I clinical trial in New Zealand (NCT04818801).
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The categories of this paper are: pharmacology
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The categories of this paper are: biophysics
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The categories of this paper are: biology
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The categories of this paper are: evolutionary
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The categories of this paper are: epidemiology
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The categories of this paper are: cancer
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The categories of this paper are: zoology
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The categories of this paper are: animal
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The categories of this paper are: ecology
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The categories of this paper are: pathology
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The categories of this paper are: neuroscience
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The categories of this paper are: education
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The categories of this paper are: plant
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The categories of this paper are: developmental
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The categories of this paper are: bioengineering
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The categories of this paper are: genomics