Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Multiple trajectory alignment reconstructs disease dynamics for discovery and clinical benefit Biological processes are changes occurring concomitantly over time. Therefore, any comparison ignorant of temporal changes is greatly deficient. Even in longitudinal experimental designs, data is usually collected at fixed intervals, whereas process dynamics vary between individuals. We developed TimeAx, which brings time into the equation by building a comparative framework for capturing biological processes dynamics from  omic data. We used TimeAx to study influenza infection dynamics and Urothelial bladder cancer tumorigenesis, discovering molecular mechanisms that drive disease progression as well as promoting clinical symptoms, for short and long term biological processes. Specifically, we detected an "inflection point", where the tumor progresses into an advanced, pro-metastatic state. Overall, we present a powerful framework for studying high resolution temporal dynamics, providing improved molecular interoperability and clinical benefit.
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The categories of this paper are: genomics
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The categories of this paper are: zoology
6
The categories of this paper are: plant
7
The categories of this paper are: ecology
28
The categories of this paper are: communication
16
The categories of this paper are: microbiology
21
The categories of this paper are: toxicology
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The categories of this paper are: immunology
3
The categories of this paper are: evolutionary
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The categories of this paper are: pharmacology
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The categories of this paper are: biophysics
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The categories of this paper are: neuroscience
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The categories of this paper are: cell
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The categories of this paper are: developmental
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The categories of this paper are: animal
22
The categories of this paper are: physiology