Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Crystal structure of the potato leafroll virus coat protein and implications for viral assembly Luteoviruses, poleroviruses, and enamoviruses are insect-transmitted, agricultural pathogens that infect a wide array of staple food crops. Previous cryo-electron microscopy studies of virus-like particles indicate that luteovirid viral capsids are built from a structural coat protein that organizes with T=3 icosahedral symmetry. Here we present the crystal structure of a truncated version of the coat protein monomer from potato leafroll virus at 1.57-[A] resolution. In the crystal lattice, monomers pack into flat sheets that preserve the two-fold and three-fold axes of icosahedral symmetry and show minimal structural deviations when compared to the full-length subunits of the assembled virus-like particle. These observations have important implications in viral assembly and maturation, suggesting that the CP N-terminus and its interactions with RNA serve as a key driver for generating capsid curvature.
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The categories of this paper are: systems
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The categories of this paper are: education
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The categories of this paper are: bioinformatics
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The categories of this paper are: molecular
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The categories of this paper are: genetics
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The categories of this paper are: cell
31
The categories of this paper are: paleontology
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The categories of this paper are: physiology
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The categories of this paper are: neuroscience
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The categories of this paper are: scientific
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The categories of this paper are: synthetic
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The categories of this paper are: animal
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The categories of this paper are: behavior
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The categories of this paper are: genomics
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The categories of this paper are: zoology
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The categories of this paper are: biophysics