Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Aging clocks, entropy, and the limits of age-reversal We analyze aging signatures in the DNA-methylation and Electronic Medical Records from the UK Biobank datasets and observe that aging is driven by a large number of individually rare and independent transitions between metastable states in a vast configuration space. The compound effect of the configuration changes can be captured by a single stochastic variable, the thermodynamic biological age (tBA), tracking the entropy produced and hence the information lost in the aging process. We show that tBA increases with age, causes the linear aging drift of physiological state variables, reduces resilience, and drives the exponential acceleration of the risks of chronic diseases and death. The entropic character of the aging drift sets limits on possibilities of age-reversal. However, the universal features of configuration transitions suggest practical ways of controlling the rate of aging and thus promising the strongest possible life-extension effects.
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The categories of this paper are: developmental
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The categories of this paper are: scientific
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The categories of this paper are: microbiology
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The categories of this paper are: neuroscience
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The categories of this paper are: and
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The categories of this paper are: molecular
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The categories of this paper are: epidemiology
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The categories of this paper are: communication
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The categories of this paper are: animal
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The categories of this paper are: plant
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The categories of this paper are: paleontology
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The categories of this paper are: zoology
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The categories of this paper are: immunology
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The categories of this paper are: toxicology
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The categories of this paper are: education
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The categories of this paper are: behavior