Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Simulating pharmaceutical treatment effects on osteoporosis via a bone
  remodeling algorithm targeting hypermineralized sites   Pharmaceutical treatments can slow bone degradation, thus reducing the
fracture risk inherent in osteoporosis. Antiresorptive treatments block the
over-activation of osteoclasts vs osteoblasts, but the resulting decrease in
bone remodeling frequency may weaken bone structure over time, with no gain in
bone volume. Anabolic treatments, however, induce gain in bone volume. The
quantitative results from existing studies on the effects of treatments over
time are general and nonpatient-specific, while numerical models simulating
evolution of patient-specific bone microarchitecture consider a spatially
random distribution of the remodeling process. Here, we propose a new approach
to simulate the remodeling over decades of an individual patient's bone
microarchitecture, based on the hypothesis that the oldest sites, which are
hypermineralized and more brittle, are remodeled first. Taking these older
sites as prime targets of remodeling, simulations show that severe osteoporosis
profoundly degrades the mechanical properties of the bone structure, which can
be restored and even improved by anabolic, more than by antiresorptive,
therapies.

27
The categories of this paper are: comp-gas
34
The categories of this paper are: chem-ph
17
The categories of this paper are: q-fin
10
The categories of this paper are: q-bio
5
The categories of this paper are: gr-qc
18
The categories of this paper are: econ
36
The categories of this paper are: cmp-lg
22
The categories of this paper are: chao-dyn
8
The categories of this paper are: hep-ex
25
The categories of this paper are: patt-sol
12
The categories of this paper are: nucl-th
24
The categories of this paper are: dg-ga
9
The categories of this paper are: nlin
37
The categories of this paper are: supr-con
6
The categories of this paper are: astro-ph
0
The categories of this paper are: hep-ph