Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A cellular and molecular portrait of endometriosis subtypes Endometriosis is a common, benign condition characterized by extensive heterogeneity in lesion appearance and patient symptoms. We profiled transcriptomes of 207,949 individual cells from endometriomata (n=7), extra-ovarian endometriosis (n=19), eutopic endometrium (n=4), unaffected ovary (n=1) and endometriosis-free peritoneum (n=4) to create a cellular atlas of endometrial-type epithelial cells, endometrial-type stromal cells and microenvironmental cell populations across tissue sites. Signatures of endometrial-type epithelium and stroma differed markedly across eutopic endometrium, endometrioma, superficial extra-ovarian disease and deep infiltrating endometriosis, suggesting that extensive transcriptional reprogramming is a core component of the disease process. Endometriomas were notable for the dysregulation of pro-inflammatory pathways and upregulation of complement proteins C3 and C7. Somatic ARID1A mutation in epithelial cells was associated with upregulation of pro-angiogenic factor SOX17 and remodeling of the endothelial cell compartment. Finally, signatures of endometriosis-associated endometrial-type epithelial clusters were enriched in ovarian cancers, reinforcing the epidemiologic associations between these two diseases.
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The categories of this paper are: microbiology
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The categories of this paper are: animal
29
The categories of this paper are: education
0
The categories of this paper are: genetics
6
The categories of this paper are: plant
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The categories of this paper are: cognition
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The categories of this paper are: ecology
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The categories of this paper are: biology
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The categories of this paper are: synthetic
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The categories of this paper are: molecular
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The categories of this paper are: cancer
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The categories of this paper are: cell
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The categories of this paper are: epidemiology
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The categories of this paper are: bioengineering
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The categories of this paper are: bioinformatics
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The categories of this paper are: neuroscience