Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Bridging disconnected networks of first and second lines of biologic
  therapies in rheumatoid arthritis with registry data: Bayesian evidence
  synthesis with target trial emulation   Objective: We aim to utilise real world data in evidence synthesis to
optimise an evidence base for the effectiveness of biologic therapies in
rheumatoid arthritis in order to allow for evidence on first-line therapies to
inform second-line effectiveness estimates. Study design and setting: We use
data from the British Society for Rheumatology Biologics Register for
Rheumatoid Arthritis (BSRBR-RA) to supplement RCT evidence obtained from the
literature, by emulating target trials of treatment sequences to estimate
treatment effects in each line of therapy. Treatment effects estimates from the
target trials inform a bivariate network meta-analysis (NMA) of first and
second-line treatments. Results: Summary data were obtained from 21 trials of
biologic therapies including 2 for second-line treatment and results from six
emulated target trials of both treatment lines. Bivariate NMA resulted in a
decrease in uncertainty around the effectiveness estimates of the second-line
therapies, when compared to the results of univariate NMA, and allowed for
predictions of treatment effects not evaluated in second-line RCTs. Conclusion:
Bivariate NMA provides effectiveness estimates for all treatments in first- and
second-line, including predicted effects in second-line where these estimates
did not exist in the data. This novel methodology may have further
applications, for example for bridging networks of trials in children and
adults.

33
The categories of this paper are: plasm-ph
12
The categories of this paper are: nucl-th
34
The categories of this paper are: chem-ph
17
The categories of this paper are: q-fin
20
The categories of this paper are: acc-phys
14
The categories of this paper are: math-ph
25
The categories of this paper are: patt-sol
1
The categories of this paper are: cs
11
The categories of this paper are: hep-lat
6
The categories of this paper are: astro-ph
18
The categories of this paper are: econ
10
The categories of this paper are: q-bio
24
The categories of this paper are: dg-ga
30
The categories of this paper are: q-alg
37
The categories of this paper are: supr-con
7
The categories of this paper are: hep-th