Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Machine learning approaches to predict the plant-associated phenotype of Xanthomonas strains The genus Xanthomonas has long been considered to consist predominantly of plant pathogens, but over the last decade there has been an increasing number of reports on non-pathogenic and endophytic members. As Xanthomonas species are prevalent pathogens on a wide variety of important crops around the world, there is a need to distinguish between these plant-associated phenotypes. To date a large number of Xanthomonas genomes have been sequenced, which enables the application of machine learning (ML) approaches on the genome content to predict this phenotype. Until now such approaches to the pathogenomics of Xanthomonas strains have been hampered by the fragmentation of information regarding strain pathogenicity over many studies. Unification of this information into a single resource was therefore considered to be an essential step. Mining of 39 papers considering both plant-associated phenotypes, allowed for a phenotypic classification of 578 Xanthomonas strains. For 65 plant-pathogenic and 53 non-pathogenic strains the corresponding genomes were available and de novo annotated for the presence of Pfam protein domains used as features to train and compare three ML classification algorithms; CART, Lasso and Random Forest. Recursive feature extraction provided further insights into the virulence enabling factors, but also yielded domains linked to traits not present in pathogenic strains.
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The categories of this paper are: genetics
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The categories of this paper are: bioinformatics
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The categories of this paper are: cell
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The categories of this paper are: ecology
22
The categories of this paper are: physiology
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The categories of this paper are: epidemiology
27
The categories of this paper are: pathology
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The categories of this paper are: cognition
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The categories of this paper are: zoology
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The categories of this paper are: neuroscience
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The categories of this paper are: synthetic
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The categories of this paper are: education
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The categories of this paper are: systems
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The categories of this paper are: biochemistry
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The categories of this paper are: animal
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The categories of this paper are: bioengineering