Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: Spatial patterns of dental disease in patients with low salivary flow Low salivary flow, or hyposalivation, is associated with an increased incidence of dental caries and a shift in their location from biting surfaces towards coronal and root surfaces. However, the relationship between salivary flow and periodontal disease is less clear. To identify clinical indicators of low salivary flow -- including the spatial pattern of dental and periodontal disease, features of the supra- and subgingival microbiota, and symptoms of dry mouth -- we enrolled individuals into two cohorts. The low flow cohort (N = 32) consisted of individuals with a presumptive diagnosis of the autoimmune disorder Sjogrens Syndrome (SS) while the control cohort (N = 119) consisted of healthy controls. We constructed a series of tooth-specific linear models to quantify the extent to which patient cohort, age, and unstimulated whole salivary flow rate (UWS-FR), independent of each other, are associated with dental and periodontal disease at each tooth. While age and a diagnosis of SS correlated with the site-specific increment of disease so too did UWS-FR. Not only were lower UWS-FRs associated with a greater number of decayed, missing, or filled surfaces at 21 teeth, but they were also associated with increased recession, as measured by clinical attachment loss (CAL), at 10 teeth (adjusted p < 0.05). In addition, we examined microbiota community structure at different tooth sites using data from 427 subgingival and supragingival samples of 6 individuals and found that microbial dispersal is reduced in patients with low salivary flow, but only at supragingival and not at subgingival sites. Finally, we found that complaints by subjects of a negative impact on overall quality of life were associated with a UWS-FR less than 0.1 mL/min. Overall, our results suggest that novel predictors of hyposalivation can be identified by integrating clinical, microbial, and patient history data.
4
The categories of this paper are: reproductive
32
The categories of this paper are: rehabilitation
56
The categories of this paper are: research
67
The categories of this paper are: transplantation
39
The categories of this paper are: rheumatology
3
The categories of this paper are: sexual
46
The categories of this paper are: therapeutics
5
The categories of this paper are: health
14
The categories of this paper are: cardiovascular
58
The categories of this paper are: hematology
24
The categories of this paper are: oncology
54
The categories of this paper are: gynecology
13
The categories of this paper are: genetic
25
The categories of this paper are: improvement
16
The categories of this paper are: immunology
60
The categories of this paper are: addiction