Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Synthesis and Pharmacology of Ester Modified (+/-)-threo-Methylphenidate
  Analogs   As part of a program to develop compounds with potential to treat cocaine
abuse, eleven (+/-)-threo-methylphenidate (TMP; Ritalin) derivatives were
synthesized and tested in rat striatal tissue preparations for inhibitory
potency against [3H]WIN 35,428 binding (WIN) to the dopamine (DA) transporter,
[3H]citalopram binding (CIT) to the serotonin transporter, and [3H]DA uptake.
The ester function was replaced by other functional groups in all of the
compounds; some also contained substituents on the phenyl ring and/or the
piperidine nitrogen. Potencies against WIN, measured as IC50, ranged from 27 nM
to 7,000 nM, compared to an IC50 of 83 nM for TMP itself. Potency against
[3H]DA uptake was approximately two-fold less than that against WIN, but
generally exhibited the same rank order. With one exception, the compounds were
significantly less potent against CIT than WIN. The one exception, which has a
rigid planar conformation at the altered ester position, is unique in that it
also is much less potent against [3H]DA uptake relative to WIN, compared to the
other derivatives. The three compounds with dichloro groups on the phenyl ring
did not exhibit positive cooperativity, as has been observed with several
previously synthesized halogenated TMP derivatives. Taken together, these
compounds should help to further our understanding of the stimulant binding
sites on both the dopamine and serotonin transporters.

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The categories of this paper are: mtrl-th
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The categories of this paper are: atom-ph
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The categories of this paper are: stat
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The categories of this paper are: chao-dyn
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The categories of this paper are: bayes-an
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The categories of this paper are: q-fin
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The categories of this paper are: quant-ph
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The categories of this paper are: chem-ph
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The categories of this paper are: eess
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The categories of this paper are: cs
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The categories of this paper are: acc-phys
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The categories of this paper are: funct-an
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The categories of this paper are: econ
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The categories of this paper are: nucl-ex
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The categories of this paper are: nucl-th
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The categories of this paper are: patt-sol