Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Retrosplenial cortex is necessary for spatial and non-spatial latent learning in mice Latent learning occurs when associations are formed between stimuli in the absence of explicit reinforcement. Traditionally, latent learning in rodents has been associated with the creation internal models of space. However, increasing evidence points to roles of internal models also in non-spatial decision making. Whether the same brain structures and processes support the creation of spatially-anchored or non-spatial internal models via latent learning, is an open question. To address this question, we developed a novel operant box task that allows to test spatial and non-spatial versions of a flavour-based sensory preconditioning paradigm. We probed the role of the retrosplenial cortex, a brain area associated with spatial cognition and subjective value representation, in this task using precise, closed-loop optogenetic silencing during different task phases. We show that the retrosplenial cortex is necessary for both spatial and non-spatial latent learning in mice. We further demonstrate that the requirement of retrosplenial cortex is limited to the preconditioning phase of the task. Our results provide insight into the specific role of the retrosplenial cortex in latent learning, demonstrate that latent learning plays a general part in the creation of internal models, independent of spatial anchors, and provide a novel avenue for studying model-based decision making.
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The categories of this paper are: biophysics
29
The categories of this paper are: education
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The categories of this paper are: genomics
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The categories of this paper are: microbiology
23
The categories of this paper are: immunology
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The categories of this paper are: biochemistry
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The categories of this paper are: behavior
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The categories of this paper are: epidemiology
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The categories of this paper are: biology
30
The categories of this paper are: scientific
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The categories of this paper are: and
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The categories of this paper are: communication
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The categories of this paper are: ecology
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The categories of this paper are: plant
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The categories of this paper are: systems
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The categories of this paper are: cancer