Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Energy fluctuations shape free energy of nonspecific biomolecular
  interactions   Understanding design principles of biomolecular recognition is a key question
of molecular biology. Yet the enormous complexity and diversity of biological
molecules hamper the efforts to gain a predictive ability for the free energy
of protein-protein, protein-DNA, and protein-RNA binding. Here, using a variant
of the Derrida model, we predict that for a large class of biomolecular
interactions, it is possible to accurately estimate the relative free energy of
binding based on the fluctuation properties of their energy spectra, even if a
finite number of the energy levels is known. We show that the free energy of
the system possessing a wider binding energy spectrum is almost surely lower
compared with the system possessing a narrower energy spectrum. Our predictions
imply that low-affinity binding scores, usually wasted in protein-protein and
protein-DNA docking algorithms, can be efficiently utilized to compute the free
energy. Using the results of Rosetta docking simulations of protein-protein
interactions from Andre et al., Proc. Natl. Acad. Sci. U.S.A. 105, 16148
(2008), we demonstrate the power of our predictions.

34
The categories of this paper are: chem-ph
29
The categories of this paper are: funct-an
4
The categories of this paper are: cond-mat
21
The categories of this paper are: adap-org
2
The categories of this paper are: math
18
The categories of this paper are: econ
0
The categories of this paper are: hep-ph
25
The categories of this paper are: patt-sol
37
The categories of this paper are: supr-con
7
The categories of this paper are: hep-th
9
The categories of this paper are: nlin
26
The categories of this paper are: bayes-an
1
The categories of this paper are: cs
15
The categories of this paper are: nucl-ex
12
The categories of this paper are: nucl-th
23
The categories of this paper are: solv-int