Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Limiting energy dissipation induces glassy kinetics in single cell high
  precision responses   Single cells often generate precise responses by involving dissipative
out-of-thermodynamic equilibrium processes in signaling networks. The available
free energy to fuel these processes could become limited depending on the
metabolic state of an individual cell. How does limiting dissipation affect the
kinetics of high precision responses in single cells? I address this question
in the context of a kinetic proofreading scheme used in a simple model of early
time T cell signaling. I show using exact analytical calculations and numerical
simulations that limiting dissipation qualitatively changes the kinetics in
single cells marked by emergence of slow kinetics, large cell-to-cell
variations of copy numbers, temporally correlated stochastic events (dynamic
facilitation), and, ergodicity breaking. Thus, constraints in energy
dissipation, in addition to negatively affecting ligand discrimination in T
cells, can create a fundamental difficulty in interpreting single cell kinetics
from cell population level results.

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The categories of this paper are: math-ph
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The categories of this paper are: q-fin
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The categories of this paper are: physics
32
The categories of this paper are: atom-ph
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The categories of this paper are: supr-con
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The categories of this paper are: hep-th
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The categories of this paper are: chem-ph
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The categories of this paper are: chao-dyn
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The categories of this paper are: acc-phys
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The categories of this paper are: adap-org
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The categories of this paper are: plasm-ph
0
The categories of this paper are: hep-ph
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The categories of this paper are: mtrl-th
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The categories of this paper are: eess
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The categories of this paper are: hep-ex
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The categories of this paper are: cs