Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting randomly-arranged sarbecovirus spike receptor-binding domains (RBDs) to elicit antibodies against conserved/relatively-occluded, rather than variable/immunodominant/exposed, epitopes. We compared immune responses elicited by mosaic-8 (SARS-CoV-2 and seven animal sarbecoviruses) and homotypic (only SARS-CoV-2) RBD-nanoparticles in mice and macaques, observing stronger responses elicited by mosaic-8 to mismatched (not on nanoparticles) strains including SARS-CoV and animal sarbecoviruses. Mosaic-8 immunization showed equivalent neutralization of SARS-CoV-2 variants including Omicron and protected from SARS-CoV-2 and SARS-CoV challenges, whereas homotypic SARS-CoV-2 immunization protected only from SARS-CoV-2 challenge. Epitope mapping demonstrated increased targeting of conserved epitopes after mosaic-8 immunization. Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.
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The categories of this paper are: molecular
30
The categories of this paper are: scientific
7
The categories of this paper are: ecology
24
The categories of this paper are: cancer
19
The categories of this paper are: epidemiology
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The categories of this paper are: communication
32
The categories of this paper are: zoology
1
The categories of this paper are: bioinformatics
3
The categories of this paper are: evolutionary
5
The categories of this paper are: cell
25
The categories of this paper are: bioengineering
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The categories of this paper are: immunology
10
The categories of this paper are: and
31
The categories of this paper are: paleontology
15
The categories of this paper are: developmental
26
The categories of this paper are: biochemistry