Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Vγ usage distinguishes pro- and anti-tumor intestinal γδ T cell subsets {gamma}{delta} T cells physiologically scan the intestinal epithelium, representing a substantial fraction of infiltrating lymphocytes in colorectal cancer (CRC), albeit their role in CRC remains unclear. Using murine CRC models, we found that most {gamma}{delta} T cells in pre- or non-tumor colon express V{gamma}1+ or V{gamma}7+ and exhibit a cytotoxic profile. Targeting these {gamma}{delta} T cell subsets, as well as conditionally interfering with {gamma}{delta} T cell function at early stages of tumorigenesis led to heightened tumor development, suggesting anti-CRC functions for V{gamma}1+ and V{gamma}7+ subsets. In contrast, ROR{gamma}t+ {gamma}{delta} T cell subsets, including V{gamma}4+ and microbiotadependent V{gamma}6+, accumulated during CRC progression. Conditional deletion of ROR{gamma}t or V{gamma} chains revealed redundant roles for IL-17-producing V{gamma}4+ and V{gamma}6+ {gamma}{delta} T cells in promoting tumor growth. Our results uncover pro- and anti-tumor roles for {gamma}{delta} T cell subsets.
19
The categories of this paper are: epidemiology
27
The categories of this paper are: pathology
31
The categories of this paper are: paleontology
5
The categories of this paper are: cell
17
The categories of this paper are: molecular
12
The categories of this paper are: behavior
1
The categories of this paper are: bioinformatics
20
The categories of this paper are: pharmacology
24
The categories of this paper are: cancer
22
The categories of this paper are: physiology
6
The categories of this paper are: plant
14
The categories of this paper are: biophysics
13
The categories of this paper are: animal
3
The categories of this paper are: evolutionary
21
The categories of this paper are: toxicology
2
The categories of this paper are: biology