Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons
  Reveals Somatic Nanoclusters   Voltage-gated sodium (Na$_\mathrm{v}$) channels are responsible for the
depolarizing phase of the action potential in most nerve cells, and
Na$_\mathrm{v}$ channel localization to the axon initial segment is vital to
action potential initiation. Na$_\mathrm{v}$ channels in the soma play a role
in the transfer of axonal output information to the rest of the neuron and in
synaptic plasticity, although little is known about Na$_\mathrm{v}$ channel
localization and dynamics within this neuronal compartment. This study uses
single-particle tracking and photoactivation localization microscopy to analyze
cell-surface Na$_\mathrm{v}$1.6 within the soma of cultured hippocampal
neurons. Mean-square displacement analysis of individual trajectories indicated
that half of the somatic Na$_\mathrm{v}$1.6 channels localized to stable
nanoclusters $\sim$230 nm in diameter. Strikingly, these domains were
stabilized at specific sites on the cell membrane for >30 min, notably via an
ankyrin-independent mechanism, indicating that the means by which
Na$_\mathrm{v}$1.6 nanoclusters are maintained in the soma is biologically
different from axonal localization. Nonclustered Na$_\mathrm{v}$1.6 channels
showed anomalous diffusion, as determined by mean-square-displacement analysis.
High-density single-particle tracking of Na$_\mathrm{v}$ channels labeled with
photoactivatable fluorophores in combination with Bayesian inference analysis
was employed to characterize the surface nanoclusters. A subpopulation of
mobile Na$_\mathrm{v}$1.6 was observed to be transiently trapped in the
nanoclusters. Somatic Na$_\mathrm{v}$1.6 nanoclusters represent a new, to our
knowledge, type of Na$_\mathrm{v}$ channel localization, and are hypothesized
to be sites of localized channel regulation.

21
The categories of this paper are: adap-org
32
The categories of this paper are: atom-ph
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The categories of this paper are: astro-ph
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The categories of this paper are: eess
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The categories of this paper are: solv-int
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The categories of this paper are: q-bio
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The categories of this paper are: q-fin
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The categories of this paper are: quant-ph
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The categories of this paper are: alg-geom
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The categories of this paper are: hep-ex
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The categories of this paper are: econ
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The categories of this paper are: dg-ga
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The categories of this paper are: supr-con
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The categories of this paper are: mtrl-th
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The categories of this paper are: math
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The categories of this paper are: comp-gas