Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Global analysis of more than 50,000 SARS-Cov-2 genomes reveals epistasis
  between 8 viral genes   Genome-wide epistasis analysis is a powerful tool to infer gene interactions,
which can guide drug and vaccine development and lead to a deeper understanding
of microbial pathogenesis. We have considered all complete SARS-CoV-2 genomes
deposited in the GISAID repository until \textbf{four} different cut-off dates,
and used Direct Coupling Analysis together with an assumption of Quasi-Linkage
Equilibrium to infer epistatic contributions to fitness from polymorphic loci.
We find \textbf{eight} interactions, of which three between pairs where one
locus lies in gene ORF3a, both loci holding non-synonymous mutations. We also
find interactions between two loci in gene nsp13, both holding non-synonymous
mutations, and four interactions involving one locus holding a synonymous
mutation. Altogether we infer interactions between loci in viral genes ORF3a
and nsp2, nsp12 and nsp6, between ORF8 and nsp4, and between loci in genes
nsp2, nsp13 and nsp14. The paper opens the prospect to use prominent
epistatically linked pairs as a starting point to search for combinatorial
weaknesses of recombinant viral pathogens.

30
The categories of this paper are: q-alg
15
The categories of this paper are: nucl-ex
28
The categories of this paper are: alg-geom
0
The categories of this paper are: hep-ph
26
The categories of this paper are: bayes-an
27
The categories of this paper are: comp-gas
9
The categories of this paper are: nlin
29
The categories of this paper are: funct-an
7
The categories of this paper are: hep-th
5
The categories of this paper are: gr-qc
17
The categories of this paper are: q-fin
34
The categories of this paper are: chem-ph
25
The categories of this paper are: patt-sol
37
The categories of this paper are: supr-con
20
The categories of this paper are: acc-phys
19
The categories of this paper are: eess