Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Automatic dual air kerma strength treatment planning for focal
  low-dose-rate prostate brachytherapy boost using dosimetric and geometric
  constraints   Purpose: Automatic planning for focal low-dose-rate prostate brachytherapy
(LDR-PB) boost.
  Methods: A simulated annealing approach was utilized for creating automatic
focal LDR-PB boost plans using both geometric (i.e. adherence of isodose
contours to structure contours) and dosimetric constraints. In 46 patients,
four unilateral focal lesion scenarios were considered as the boost region, in
the anterior/posterior and superior/inferior quadrants. Plans consisted of
seeds with two air kerma strengths (0.740U and 0.351 or 0.354U) to achieve
required dose coverage on these smaller focal targets. Plan characteristics
(including PTV V100 and V150, Rectum V50, Urethra V150, and number of needles
and seeds), were compared in terms of type of needle loading (dual vs. single
air kerma needles), boost quadrant and prostate volume. Plans were blindly
ranked on 20 consecutive cases by two experienced radiation oncologists.
  Results: Differences in plans generated using the two needle loading
techniques were not clinically significant, particularly in terms of the PTV
V100 and V150 and Urethra V150, with single air kerma loaded needles
potentially being more practical. A higher rectal dose was observed in the
posterior boost quadrants (V50 >0.18), particularly in larger prostates (>40
cc). In smaller prostates (<25 cc), obtaining adequate dose coverage while
sparing the urethra was more challenging. 88% of the plans were considered
clinically acceptable without (46%) or with (mostly minor) modifications.
  Conclusions: The novel approach of using dual air kerma seeds combined with
geometric constraints within a simulated annealing-based automatic planning
framework can lead to focal LDR-PB plans with high acceptability.

17
The categories of this paper are: q-fin
18
The categories of this paper are: econ
7
The categories of this paper are: hep-th
27
The categories of this paper are: comp-gas
10
The categories of this paper are: q-bio
0
The categories of this paper are: hep-ph
13
The categories of this paper are: quant-ph
26
The categories of this paper are: bayes-an
14
The categories of this paper are: math-ph
2
The categories of this paper are: math
8
The categories of this paper are: hep-ex
1
The categories of this paper are: cs
28
The categories of this paper are: alg-geom
4
The categories of this paper are: cond-mat
34
The categories of this paper are: chem-ph
33
The categories of this paper are: plasm-ph