Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers Asprosin, the C-terminal furin cleavage product of profibrillin-1, was reported to act as a hormone that circulates at nanomolar levels and is recruited to the liver where it induces G protein-coupled activation of the cAMP-PKA pathway and stimulates rapid glucose release into the circulation. Although derived from profibrillin-1, a multidomain extracellular matrix glycoprotein with a ubiquitous distribution in connective tissues, little is known about the tissue distribution of asprosin. In the current view, asprosin is mainly produced by white adipose tissue from where it is released into the blood in monomeric form. Here, by employing newly generated specific asprosin antibodies we monitored the distribution pattern of asprosin in human and murine connective tissues such as placenta, and muscle. Thereby we detected the presence of asprosin positive extracellular fibers. Further, by screening established cell lines for asprosin synthesis we found that most cells derived from musculoskeletal tissues render asprosin into an oligomerized form. This oligomerization is facilitated by transglutaminase activity and requires an intact fibrillin fiber network for proper linear deposition. Our data suggest a new extracellular storage mechanism of asprosin in oligomerized form which may regulate its cellular bioavailability in tissues.
27
The categories of this paper are: pathology
31
The categories of this paper are: paleontology
18
The categories of this paper are: systems
29
The categories of this paper are: education
1
The categories of this paper are: bioinformatics
21
The categories of this paper are: toxicology
32
The categories of this paper are: zoology
24
The categories of this paper are: cancer
19
The categories of this paper are: epidemiology
13
The categories of this paper are: animal
12
The categories of this paper are: behavior
30
The categories of this paper are: scientific
8
The categories of this paper are: genomics
7
The categories of this paper are: ecology
11
The categories of this paper are: cognition
9
The categories of this paper are: synthetic