Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Control of DNA denaturation bubble nucleation to advance nano-biosensing   In the demanding biosensing environment, improving selection efficiency
strategies has become an issue of great significance. DNA minicircles
containing between 200 and 400 base-pairs, also named microDNA, are
representative of the supercoiled DNA loops found in nature. Their short size
makes them extremely susceptible to writhe and twist, which is known to play a
central role in DNA denaturation. We investigate minicircle lengths and
superhelical densities that induce DNA denaturation bubbles of nanometer size
and control well-defined long-life. Mesoscopic modeling and accelerated
dynamics simulations allow us to study accurately the thermodynamic and
dynamical properties associated with the nucleation and closure mechanisms of
long-lived denaturation bubbles. Our results pave the way for new types of DNA
biosensors with enhanced selectivity for specific DNA binding proteins.

8
The categories of this paper are: hep-ex
11
The categories of this paper are: hep-lat
14
The categories of this paper are: math-ph
18
The categories of this paper are: econ
33
The categories of this paper are: plasm-ph
37
The categories of this paper are: supr-con
19
The categories of this paper are: eess
28
The categories of this paper are: alg-geom
6
The categories of this paper are: astro-ph
1
The categories of this paper are: cs
17
The categories of this paper are: q-fin
32
The categories of this paper are: atom-ph
10
The categories of this paper are: q-bio
35
The categories of this paper are: mtrl-th
9
The categories of this paper are: nlin
34
The categories of this paper are: chem-ph