Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: ASAP-SML: An Antibody Sequence Analysis Pipeline Using Statistical
  Testing and Machine Learning   Antibodies are capable of potently and specifically binding individual
antigens and, in some cases, disrupting their functions. The key challenge in
generating antibody-based inhibitors is the lack of fundamental information
relating sequences of antibodies to their unique properties as inhibitors. We
develop a pipeline, Antibody Sequence Analysis Pipeline using Statistical
testing and Machine Learning (ASAP-SML), to identify features that distinguish
one set of antibody sequences from antibody sequences in a reference set. The
pipeline extracts feature fingerprints from sequences. The fingerprints
represent germline, CDR canonical structure, isoelectric point and frequent
positional motifs. Machine learning and statistical significance testing
techniques are applied to antibody sequences and extracted feature fingerprints
to identify distinguishing feature values and combinations thereof. To
demonstrate how it works, we applied the pipeline on sets of antibody sequences
known to bind or inhibit the activities of matrix metalloproteinases (MMPs), a
family of zinc-dependent enzymes that promote cancer progression and undesired
inflammation under pathological conditions, against reference datasets that do
not bind or inhibit MMPs. ASAP-SML identifies features and combinations of
feature values found in the MMP-targeting sets that are distinct from those in
the reference sets.

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The categories of this paper are: alg-geom
13
The categories of this paper are: quant-ph
20
The categories of this paper are: acc-phys
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The categories of this paper are: funct-an
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The categories of this paper are: eess
8
The categories of this paper are: hep-ex
11
The categories of this paper are: hep-lat
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The categories of this paper are: chem-ph
0
The categories of this paper are: hep-ph
3
The categories of this paper are: physics
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The categories of this paper are: dg-ga
14
The categories of this paper are: math-ph
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The categories of this paper are: cmp-lg
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The categories of this paper are: chao-dyn
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The categories of this paper are: nucl-th
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The categories of this paper are: stat