Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Extending the MR-Egger method for multivariable Mendelian randomization
  to correct for both measured and unmeasured pleiotropy   Methods have been developed for Mendelian randomization that can obtain
consistent causal estimates while relaxing the instrumental variable
assumptions. These include multivariable Mendelian randomization, in which a
genetic variant may be associated with multiple risk factors so long as any
association with the outcome is via the measured risk factors (measured
pleiotropy), and the MR-Egger (Mendelian randomization-Egger) method, in which
a genetic variant may be directly associated with the outcome not via the risk
factor of interest, so long as the direct effects of the variants on the
outcome are uncorrelated with their associations with the risk factor
(unmeasured pleiotropy). In this paper, we extend the MR-Egger method to a
multivariable setting to correct for both measured and unmeasured pleiotropy.
We show, through theoretical arguments and a simulation study, that the
multivariable MR-Egger method has advantages over its univariable counterpart
in terms of plausibility of the assumption needed for consistent causal
estimation, and power to detect a causal effect when this assumption is
satisfied. The methods are compared in an applied analysis to investigate the
causal effect of high-density lipoprotein cholesterol on coronary heart disease
risk. The multivariable MR-Egger method will be useful to analyse
high-dimensional data in situations where the risk factors are highly related
and it is difficult to find genetic variants specifically associated with the
risk factor of interest (multivariable by design), and as a sensitivity
analysis when the genetic variants are known to have pleiotropic effects on
measured risk factors.

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The categories of this paper are: eess
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The categories of this paper are: solv-int
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The categories of this paper are: mtrl-th
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The categories of this paper are: funct-an
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The categories of this paper are: supr-con
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The categories of this paper are: atom-ph
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The categories of this paper are: chem-ph
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The categories of this paper are: ao-sci
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The categories of this paper are: quant-ph
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The categories of this paper are: nucl-ex
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The categories of this paper are: acc-phys
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The categories of this paper are: alg-geom
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The categories of this paper are: hep-lat
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The categories of this paper are: math-ph
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The categories of this paper are: math
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The categories of this paper are: comp-gas