Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Modularity of the metabolic gene network as a prognostic biomarker for
  hepatocellular carcinoma   Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize
both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy
production and biomass synthesis. Understanding the metabolic reprogramming in
cancer can help design therapies to target metabolism and thereby to improve
prognosis. We have previously argued that more malignant tumors are usually
characterized by a more modular expression pattern of cancer-associated genes.
In this work, we analyzed the expression patterns of metabolism genes in terms
of modularity for 371 hepatocellular carcinoma (HCC) samples from the Cancer
Genome Atlas (TCGA). We found that higher modularity significantly correlated
with glycolytic phenotype, later tumor stages, higher metastatic potential, and
cancer recurrence, all of which contributed to poorer overall prognosis. Among
patients that recurred, we found the correlation of greater modularity with
worse prognosis during early to mid-progression. Furthermore, we developed
metrics to calculate individual modularity, which was shown to be predictive of
cancer recurrence and patients' survival and therefore may serve as a
prognostic biomarker. Our overall conclusion is that more aggressive HCC
tumors, as judged by decreased host survival probability, had more modular
expression patterns of metabolic genes. These results may be used to identify
cancer driver genes and for drug design.

26
The categories of this paper are: bayes-an
2
The categories of this paper are: math
35
The categories of this paper are: mtrl-th
31
The categories of this paper are: ao-sci
4
The categories of this paper are: cond-mat
25
The categories of this paper are: patt-sol
27
The categories of this paper are: comp-gas
32
The categories of this paper are: atom-ph
13
The categories of this paper are: quant-ph
36
The categories of this paper are: cmp-lg
21
The categories of this paper are: adap-org
6
The categories of this paper are: astro-ph
15
The categories of this paper are: nucl-ex
9
The categories of this paper are: nlin
3
The categories of this paper are: physics
37
The categories of this paper are: supr-con