Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Projecting ancient ancestry in modern-day Arabians and Iranians: a key role of the past exposed Arabo-Persian Gulf on human migrations Arabian Peninsula is strategic for investigations centred on the structuring of the modern human population in the three main groups, in the awake of the out-of-Africa migration. Despite the poor climatic conditions for recovery of ancient DNA human evidence in Arabia, the availability of genomic data from neighbouring ancient specimens and of informative statistical tools allow better modelling the ancestry of these populations. We applied this approach to a dataset of 741,000 variants screened in 291 Arabians and 78 Iranians, and obtained insightful evidence. The west-east axis was a strong forcer of population structure in the Peninsula, and, more importantly, there were clear continuums throughout time linking west Arabia with Levant, and east Arabia with Iran and Caucasus. East Arabians also displayed the highest levels of the basal Eurasian lineage of all tested modern-day populations, a signal that was maintained even after correcting for possible bias due to recent sub-Saharan African input in their genomes. Not surprisingly, east Arabians were also the ones with higher similarity with Iberomaurusians, who were so far the best proxy for the basal Eurasians amongst the known ancient specimens. The basal Eurasian lineage is the signature of ancient non-Africans that diverged from the common European-East Asian pool before 50 thousand years ago, and before the later interbred with Neanderthals. Our results are strong evidence to include the exposed basin of the Arabo-Persian Gulf as possible home of basal Eurasians, to be investigated further on namely by searching ancient Arabian human specimens.
29
The categories of this paper are: education
20
The categories of this paper are: pharmacology
25
The categories of this paper are: bioengineering
9
The categories of this paper are: synthetic
18
The categories of this paper are: systems
17
The categories of this paper are: molecular
2
The categories of this paper are: biology
3
The categories of this paper are: evolutionary
1
The categories of this paper are: bioinformatics
30
The categories of this paper are: scientific
16
The categories of this paper are: microbiology
11
The categories of this paper are: cognition
24
The categories of this paper are: cancer
5
The categories of this paper are: cell
19
The categories of this paper are: epidemiology
22
The categories of this paper are: physiology