Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Coronavirus RNA synthesis takes place within membrane-bound sites Infectious bronchitis virus (IBV), a gammacoronavirus, is an economically important virus to the poultry industry as well as a significant welfare issue for chickens. As for all positive strand RNA viruses, IBV infection causes rearrangements of the host cell intracellular membranes to form replication organelles. Replication organelle formation is a highly conserved and vital step in the viral life cycle. Here, we investigate the localization of viral RNA synthesis and the link with replication organelles in host cells. We have shown that sites of viral RNA synthesis and virus-related dsRNA are associated with one another and, significantly, that they are located within a membrane-bound compartment within the cell. We have also shown that some viral RNA produced early in infection remains within these membranes throughout infection. Importantly, we demonstrate conservation across all four coronavirus genera, including SARS-CoV-2. Under-standing more about the replication of these viruses is imperative in order to effectively find ways to control them.
23
The categories of this paper are: immunology
12
The categories of this paper are: behavior
7
The categories of this paper are: ecology
19
The categories of this paper are: epidemiology
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The categories of this paper are: pharmacology
14
The categories of this paper are: biophysics
17
The categories of this paper are: molecular
6
The categories of this paper are: plant
29
The categories of this paper are: education
30
The categories of this paper are: scientific
18
The categories of this paper are: systems
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The categories of this paper are: animal
25
The categories of this paper are: bioengineering
0
The categories of this paper are: genetics
24
The categories of this paper are: cancer
28
The categories of this paper are: communication