Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Decoding Dynamically Shifting States of Parkinson's Disease: Tremor, Bradykinesia, and Effective Motor Control Parkinsons Disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these different motor states could facilitate monitoring of disease progression and allow improved assessments of therapeutic efficacy, as well as enable optimal closed-loop neuromodulation. We examined neural activity in the basal ganglia and cortex of subjects with PD during a quantitative motor task to decode tremor and bradykinesia -- two cardinal motor signs of this disease -- and relatively asymptomatic periods of behavior. Analysis of subcortical and cortical signals revealed that tremor and bradykinesia had distinct, nearly opposite neural signatures, while effective motor control displayed unique, differentiating features. The neurophysiological signatures of these motor states depended on the type of signal recorded as well as the location; cortical decoding accuracy generally outperformed subcortical decoding, while tremor and bradykinesia were better decoded from different portions of the subthalamic nucleus (STN). These results provide a roadmap to leverage real-time neurophysiology to understand and treat PD.

One Sentence SummaryMotor signs of Parkinsons disease such as tremor and bradykinesia can be independently decoded from subthalamic and cortical recordings.
1
The categories of this paper are: bioinformatics
29
The categories of this paper are: education
18
The categories of this paper are: systems
27
The categories of this paper are: pathology
28
The categories of this paper are: communication
15
The categories of this paper are: developmental
9
The categories of this paper are: synthetic
31
The categories of this paper are: paleontology
21
The categories of this paper are: toxicology
7
The categories of this paper are: ecology
8
The categories of this paper are: genomics
25
The categories of this paper are: bioengineering
30
The categories of this paper are: scientific
2
The categories of this paper are: biology
22
The categories of this paper are: physiology
19
The categories of this paper are: epidemiology