Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Topological and energetic factors: what determines the structural
  details of the transition state ensemble and "on-route" intermediates for
  protein folding? An investigation for small globular proteins   Recent experimental results suggest that the native fold, or topology, plays
a primary role in determining the structure of the transition state ensemble,
at least for small fast folding proteins. To investigate the extent of the
topological control of the folding process, we study the folding of simplified
models of five small globular proteins constructed using a Go-like potential in
order to retain the information about the native structures but drastically
reduce the energetic frustration and energetic heterogeneity among
residue-residue native interactions. By comparing the structure of the
transition state ensemble experimentally determined by Phi-values and of the
intermediates with the ones obtained using our models, we show that these
energetically unfrustrated models can reproduce the global experimentally known
features of the transition state ensembles and "on-route" intermediates, at
least for the analyzed proteins. This result clearly indicates that, as long as
the protein sequence is sufficiently minimally frustrated, topology plays a
central role in determining the folding mechanism.

5
The categories of this paper are: gr-qc
18
The categories of this paper are: econ
17
The categories of this paper are: q-fin
28
The categories of this paper are: alg-geom
8
The categories of this paper are: hep-ex
12
The categories of this paper are: nucl-th
32
The categories of this paper are: atom-ph
7
The categories of this paper are: hep-th
14
The categories of this paper are: math-ph
16
The categories of this paper are: stat
3
The categories of this paper are: physics
24
The categories of this paper are: dg-ga
2
The categories of this paper are: math
0
The categories of this paper are: hep-ph
20
The categories of this paper are: acc-phys
26
The categories of this paper are: bayes-an