Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Attention-guided Quality Assessment for Automated Cryo-EM Grid Screening   Cryogenic electron microscopy (cryo-EM) has become an enabling technology in
drug discovery and in understanding molecular bases of disease by producing
near-atomic resolution (less than 0.4 nm) 3D reconstructions of biological
macromolecules. The imaging process required for 3D reconstructions involves a
highly iterative and empirical screening process, starting with the acquisition
of low magnification images of the cryo-EM grids. These images are inspected
for squares that are likely to contain useful molecular signals. Potentially
useful squares within the grid are then imaged at progressively higher
magnifications, with the goal of identifying sub-micron areas within circular
holes (bounded by the squares) for imaging at high magnification. This arduous,
multi-step data acquisition process represents a bottleneck for obtaining a
high throughput data collection. Here, we focus on automating the early
decision making for the microscope operator, scoring low magnification images
of squares, and proposing the first deep learning framework, XCryoNet, for
automated cryo-EM grid screening. XCryoNet is a semi-supervised,
attention-guided deep learning approach that provides explainable scoring of
automatically extracted square images using limited amounts of labeled data.
Results show up to 8% and 37% improvements over a fully supervised and a
no-attention solution, respectively, when labeled data is scarce.

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The categories of this paper are: dg-ga
11
The categories of this paper are: hep-lat
15
The categories of this paper are: nucl-ex
37
The categories of this paper are: supr-con
29
The categories of this paper are: funct-an
35
The categories of this paper are: mtrl-th
17
The categories of this paper are: q-fin
10
The categories of this paper are: q-bio
4
The categories of this paper are: cond-mat
34
The categories of this paper are: chem-ph
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The categories of this paper are: ao-sci
30
The categories of this paper are: q-alg
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The categories of this paper are: econ
28
The categories of this paper are: alg-geom
0
The categories of this paper are: hep-ph
6
The categories of this paper are: astro-ph