Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Toward the automated analysis of complex diseases in genome-wide
  association studies using genetic programming   Machine learning has been gaining traction in recent years to meet the demand
for tools that can efficiently analyze and make sense of the ever-growing
databases of biomedical data in health care systems around the world. However,
effectively using machine learning methods requires considerable domain
expertise, which can be a barrier of entry for bioinformaticians new to
computational data science methods. Therefore, off-the-shelf tools that make
machine learning more accessible can prove invaluable for bioinformaticians. To
this end, we have developed an open source pipeline optimization tool
(TPOT-MDR) that uses genetic programming to automatically design machine
learning pipelines for bioinformatics studies. In TPOT-MDR, we implement
Multifactor Dimensionality Reduction (MDR) as a feature construction method for
modeling higher-order feature interactions, and combine it with a new expert
knowledge-guided feature selector for large biomedical data sets. We
demonstrate TPOT-MDR's capabilities using a combination of simulated and real
world data sets from human genetics and find that TPOT-MDR significantly
outperforms modern machine learning methods such as logistic regression and
eXtreme Gradient Boosting (XGBoost). We further analyze the best pipeline
discovered by TPOT-MDR for a real world problem and highlight TPOT-MDR's
ability to produce a high-accuracy solution that is also easily interpretable.

12
The categories of this paper are: nucl-th
23
The categories of this paper are: solv-int
27
The categories of this paper are: comp-gas
4
The categories of this paper are: cond-mat
32
The categories of this paper are: atom-ph
22
The categories of this paper are: chao-dyn
34
The categories of this paper are: chem-ph
35
The categories of this paper are: mtrl-th
6
The categories of this paper are: astro-ph
11
The categories of this paper are: hep-lat
7
The categories of this paper are: hep-th
19
The categories of this paper are: eess
37
The categories of this paper are: supr-con
33
The categories of this paper are: plasm-ph
28
The categories of this paper are: alg-geom
17
The categories of this paper are: q-fin