Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A type I interferon response defines a conserved microglial state required for effective phagocytosis Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I interferon (IFN-I) responsive microglia population that expanded with this developmental stressor. Using the marker gene IFITM3 we found that IFN-I responsive microglia were engulfing whole neurons. Loss of IFN-I signaling (Ifnar1-/-) resulted in dysmorphic  bubble microglia with enlarged phagolysosomal compartments. We also observed a reduction in dead cells and an accumulation of neurons with double strand DNA breaks, a marker of cell stress. Conversely, IFN-I gain of function in zebrafish was sufficient to drive microglial engulfment of whole neurons. We identified IFITM3+ microglia in two murine disease models: SARS-CoV-2 infection and the 5xFAD model of Alzheimers disease. These data reveal a novel role for IFN-I signaling in regulating efficient neuronal clearance by microglia.
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The categories of this paper are: epidemiology
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The categories of this paper are: and
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The categories of this paper are: biology
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The categories of this paper are: physiology
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The categories of this paper are: communication
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The categories of this paper are: zoology
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The categories of this paper are: immunology
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The categories of this paper are: biophysics
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The categories of this paper are: plant
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The categories of this paper are: developmental
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The categories of this paper are: scientific
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The categories of this paper are: pharmacology
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The categories of this paper are: toxicology
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The categories of this paper are: paleontology
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The categories of this paper are: behavior
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The categories of this paper are: bioengineering