Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Insights into Complex Brain Functions Related to Schizophrenia Disorder
  through Causal Network Analysis   Gene expression represents a fundamental interface between genes and
environment in the development and ongoing plasticity of the human organism.
Individual differences in gene expression are likely to underpin much of human
diversity, including psychiatric illness. Gene expression shows a distinct
regulatory pattern in different tissues. Therefore, brain tissue analysis
provides insights into brain disorder mechanisms. Furthermore, mechanistic
understanding of gene regulatory pattern can be provided through studying the
underlying relationships as a complex network. Identification of brain specific
gene relationships provides a complementary framework in which to tackle the
complex dysregulations that occur in neuropsychiatric and other neurological
disorders. Using a systems approach established in Mendelian randomization and
Bayesian Network, we integrated genetic and transcriptomic data from the
common-mind consortium and identified transcriptomic causal networks in
observational studies. Focusing on Schizophrenia disorder, we identified high
impact genes and revealed their underlying pathways in brain tissue. In
addition, we generated novel hypotheses including genes as causes of the
schizophrenia-associated genes and new genes associated with Schizophrenia.
This approach may facilitate a better understanding of the disease mechanism
that is complementary to molecular experimental studies especially for complex
systems and large-scale data sets.

3
The categories of this paper are: physics
0
The categories of this paper are: hep-ph
7
The categories of this paper are: hep-th
24
The categories of this paper are: dg-ga
9
The categories of this paper are: nlin
17
The categories of this paper are: q-fin
25
The categories of this paper are: patt-sol
13
The categories of this paper are: quant-ph
33
The categories of this paper are: plasm-ph
28
The categories of this paper are: alg-geom
8
The categories of this paper are: hep-ex
36
The categories of this paper are: cmp-lg
1
The categories of this paper are: cs
20
The categories of this paper are: acc-phys
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The categories of this paper are: ao-sci
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The categories of this paper are: eess