Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A Hierarchical Approach to Protein Molecular Evolution   Biological diversity has evolved despite the essentially infinite complexity
of protein sequence space. We present a hierarchical approach to the efficient
searching of this space and quantify the evolutionary potential of our approach
with Monte Carlo simulations. These simulations demonstrate that non-homologous
juxtaposition of encoded structure is the rate-limiting step in the production
of new tertiary protein folds. Non-homologous ``swapping'' of low energy
secondary structures increased the binding constant of a simulated protein by
$\approx10^7$ relative to base substitution alone. Applications of our approach
include the generation of new protein folds and modeling the molecular
evolution of disease.

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The categories of this paper are: math-ph
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The categories of this paper are: hep-ex
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The categories of this paper are: q-fin
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The categories of this paper are: nucl-ex
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The categories of this paper are: stat
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The categories of this paper are: solv-int
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The categories of this paper are: cmp-lg
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The categories of this paper are: atom-ph
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The categories of this paper are: q-alg
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The categories of this paper are: alg-geom
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The categories of this paper are: patt-sol
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The categories of this paper are: astro-ph
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The categories of this paper are: adap-org
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The categories of this paper are: comp-gas
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The categories of this paper are: nlin
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The categories of this paper are: econ