Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity Tissue-resident macrophages exert critical but conflicting effects on the progression of coronavirus infections by secreting both anti-viral type I Interferons and tissue-damaging inflammatory cytokines. Steroids, the only class of host-targeting drugs approved for Covid19, indiscriminately suppress both responses, possibly impairing viral clearance, and provide limited clinical benefit. Here we set up a mouse in vitro co-culture system that reproduces the macrophage response to SARS-CoV2 seen in patients and allows quantitation of inflammatory and antiviral activities. We show that the NFKB-dependent inflammatory response can be selectively inhibited by ablating the lysine-demethylase LSD1, which additionally unleashed interferon-independent ISG activation and blocked viral egress through the lysosomal pathway. These results provide a rationale for repurposing LSD1 inhibitors, a class of drugs extensively studied in oncology, for Covid-19 treatment.

One-Sentence SummaryTargeting a chromatin-modifying enzyme in coronavirus infections curbs tissue-damage without affecting antiviral response
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The categories of this paper are: scientific
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The categories of this paper are: cancer
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The categories of this paper are: plant
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The categories of this paper are: toxicology
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The categories of this paper are: biochemistry
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The categories of this paper are: neuroscience
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The categories of this paper are: and
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The categories of this paper are: pharmacology
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The categories of this paper are: biology
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The categories of this paper are: microbiology
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The categories of this paper are: education
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The categories of this paper are: communication
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The categories of this paper are: genetics
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The categories of this paper are: evolutionary
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The categories of this paper are: bioinformatics
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The categories of this paper are: molecular