Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Complexity in cancer stem cells and tumor evolution: towards precision
  medicine   In this review, we discuss recent advances on the plasticity of cancer stem
cells and highlight their relevance to understand the metastatic process and to
guide therapeutic interventions. Recent results suggest that the strict
hierarchical structure of cancer cell populations advocated by the cancer stem
cell model must be reconsidered since the depletion of cancer stem cells leads
the other tumor cells to switch back into the cancer stem cell phenotype. This
plasticity has important implications for metastasis since migrating cells do
not need to be cancer stem cells in order to seed a metastasis. We also discuss
the important role of the immune system and the microenvironment in modulating
phenotypic switching and suggest possible avenues to exploit our understanding
of this process to develop an effective strategy for precision medicine.

8
The categories of this paper are: hep-ex
21
The categories of this paper are: adap-org
16
The categories of this paper are: stat
19
The categories of this paper are: eess
14
The categories of this paper are: math-ph
36
The categories of this paper are: cmp-lg
32
The categories of this paper are: atom-ph
6
The categories of this paper are: astro-ph
5
The categories of this paper are: gr-qc
17
The categories of this paper are: q-fin
7
The categories of this paper are: hep-th
15
The categories of this paper are: nucl-ex
1
The categories of this paper are: cs
0
The categories of this paper are: hep-ph
25
The categories of this paper are: patt-sol
18
The categories of this paper are: econ