Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants Both Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.
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The categories of this paper are: immunology
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The categories of this paper are: zoology
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The categories of this paper are: communication
30
The categories of this paper are: scientific
22
The categories of this paper are: physiology
1
The categories of this paper are: bioinformatics
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The categories of this paper are: biophysics
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The categories of this paper are: molecular
3
The categories of this paper are: evolutionary
11
The categories of this paper are: cognition
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The categories of this paper are: pharmacology
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The categories of this paper are: epidemiology
8
The categories of this paper are: genomics
31
The categories of this paper are: paleontology
10
The categories of this paper are: and
18
The categories of this paper are: systems