Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Multiscale Modeling and Analysis for High-fidelity Interferometric
  Scattering Microscopy   Interferometric scattering microscopy (iSCAT), as an ultrasensitive
fluorescence-free imaging modality, has recently gain enormous attention and
been rapidly developing from demonstration of principle to quantitative
sensing. Here we report on a theoretical and experimental study for iSCAT with
samples having structural dimensions that differ by 4-5 orders of magnitude. In
particular, we demonstrate and intuitively explain the profound effects of
sub-nanometer surface roughness of a glass coverslip and of a mica surface on
the absolute signal and the shape of the point spread function of a gold
nanoparticle. These quantities significantly affect the accuracies for
determining the target size and position in all three dimensions. Moreover, we
investigate a sample system mimicking a gold nanoparticle in a simplified cell
environment and show position-dependent and even asymmetric point spread
function of the nanoparticle. The multiscale study will facilitate the
development of high fidelity iSCAT in real applications.

14
The categories of this paper are: math-ph
31
The categories of this paper are: ao-sci
28
The categories of this paper are: alg-geom
37
The categories of this paper are: supr-con
4
The categories of this paper are: cond-mat
22
The categories of this paper are: chao-dyn
10
The categories of this paper are: q-bio
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The categories of this paper are: dg-ga
20
The categories of this paper are: acc-phys
2
The categories of this paper are: math
16
The categories of this paper are: stat
34
The categories of this paper are: chem-ph
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The categories of this paper are: eess
27
The categories of this paper are: comp-gas
5
The categories of this paper are: gr-qc
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The categories of this paper are: nucl-th