Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Resolving the degree of order in the bacterial chromosome using a
  statistical physics approach   While bacterial chromosomes were long thought to be amorphous, recent
experiments reveal pronounced organizational features. However, the extent of
bacterial chromosome organization remains unclear. Here, we develop a fully
data-driven maximum entropy approach to extract the distribution of single-cell
chromosome conformations from experimental normalized Hi-C data. We apply this
inference to the model organism Caulobacter crescentus. On small genomic scales
of 104-105 basepairs, our model reveals a pattern of local chromosome
extensions that correlates with transcriptional and DNA loop extrusion
activity. On larger genomic scales, we find that chromosome structure is
predominantly present along the long cell axis: chromosomal loci not only have
well-defined axial positions, they also exhibit long-ranged correlations due
interacting large emergent genomic clusters, termed Super Domains. Finally, our
model reveals information contained in chromosome structure that can guide
cellular processes. Our approach can be generalized to other species, providing
a principled way of analyzing spatial chromosome organization.

20
The categories of this paper are: acc-phys
22
The categories of this paper are: chao-dyn
26
The categories of this paper are: bayes-an
18
The categories of this paper are: econ
29
The categories of this paper are: funct-an
37
The categories of this paper are: supr-con
32
The categories of this paper are: atom-ph
9
The categories of this paper are: nlin
5
The categories of this paper are: gr-qc
8
The categories of this paper are: hep-ex
28
The categories of this paper are: alg-geom
34
The categories of this paper are: chem-ph
33
The categories of this paper are: plasm-ph
1
The categories of this paper are: cs
13
The categories of this paper are: quant-ph
12
The categories of this paper are: nucl-th