Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive {beta}-like cells by targeted inhibition of Foxo1. We have shown that this can be achieved by genetic ablation in gut Neurogenin3 progenitors, adenoviral or shRNA-mediated inhibition in human gut organoids, and chemical inhibition in Akita mice, a model of insulin-deficient diabetes. In the present study, we provide evidence that two novel Foxo1 inhibitors, FBT432 and FBT374 have glucose-lowering and gut {beta}-like cell-inducing properties in mice rendered insulin-deficient by administration of streptozotocin. FBT432 is also highly effective in combination with a Notch inhibitor in this model. The data add to a growing body of evidence suggesting that Foxo1 inhibition be pursued as an alternative treatment to insulin administration in diabetes.
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The categories of this paper are: behavior
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The categories of this paper are: zoology
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The categories of this paper are: biophysics
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The categories of this paper are: bioengineering
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The categories of this paper are: paleontology
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The categories of this paper are: cell
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The categories of this paper are: biochemistry
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The categories of this paper are: ecology
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The categories of this paper are: cancer
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The categories of this paper are: genetics
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The categories of this paper are: cognition
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The categories of this paper are: epidemiology
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The categories of this paper are: systems
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The categories of this paper are: neuroscience
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The categories of this paper are: immunology
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The categories of this paper are: scientific