Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Specialization in somatostatin subnetworks in sensory and association cortex Behavioral states profoundly affect cortical population activity dynamics and coding, yet the local circuits mediating these shifts are poorly understood, especially outside of sensory cortex. Somatostatin-expressing (SOM) inhibitory interneurons are highly sensitive to changes in brain state, and are well situated to modulate local population activity patterns. Here, we used two-photon calcium imaging to record the spike-related activity in populations of SOM and Non-SOM neurons in auditory cortex (AC) and posterior parietal cortex (PPC), to compare their functional interactions and activity modulation by behavioral state in sensory and association cortex. We have discovered both similarities and differences in the functional characteristics of SOM and Non-SOM populations across areas. In both regions, SOM neurons were more highly coordinated as populations than Non-SOM neurons. In PPC, SOM and Non-SOM neurons were positively modulated by increased arousal, while the effects of arousal in AC neurons were more diverse. Strikingly, the spatial structure of shared variability was different in AC and PPC: pairwise correlations in all cell types decayed rapidly with distance in AC but remained high over greater distances in PPC. Our results imply both generalization and specialization in the functional structure of excitatory and inhibitory subnetworks in sensory and association cortex.
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The categories of this paper are: systems
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The categories of this paper are: physiology
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The categories of this paper are: bioinformatics
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The categories of this paper are: epidemiology
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The categories of this paper are: bioengineering
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The categories of this paper are: immunology
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The categories of this paper are: education
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The categories of this paper are: microbiology
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The categories of this paper are: cancer
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The categories of this paper are: genomics
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The categories of this paper are: genetics
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The categories of this paper are: biophysics
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The categories of this paper are: biology
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The categories of this paper are: biochemistry
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The categories of this paper are: behavior
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The categories of this paper are: synthetic