Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Deep brain fluorescence imaging with minimally invasive ultra-thin
  optical fibers   A major open challenge in neuroscience is the ability to measure and perturb
neural activity in vivo from well-defined neural sub-populations at cellular
resolution anywhere in the brain. However, limitations posed by scattering and
absorption prohibit non-invasive (surface) multiphoton approaches for deep
(>2mm) structures, while Gradient Refreactive Index (GRIN) endoscopes are thick
and cause significant damage upon insertion. Here, we demonstrate a novel
microendoscope to image neural activity at arbitrary depths via an ultrathin
multimode optical fiber (MMF) probe that is 5-10X thinner than commercially
available microendoscopes. We demonstrate micron-scale resolution,
multispectral and volumetric imaging. In contrast to previous approaches, we
show that this method has an improved acquisition speed that is sufficient to
capture rapid neuronal dynamics in-vivo in rodents expressing a genetically
encoded calcium indicator. Our results emphasize the potential of this
technology in neuroscience applications and open up possibilities for cellular
resolution imaging in previously unreachable brain regions.

21
The categories of this paper are: adap-org
36
The categories of this paper are: cmp-lg
22
The categories of this paper are: chao-dyn
1
The categories of this paper are: cs
4
The categories of this paper are: cond-mat
14
The categories of this paper are: math-ph
37
The categories of this paper are: supr-con
33
The categories of this paper are: plasm-ph
19
The categories of this paper are: eess
12
The categories of this paper are: nucl-th
26
The categories of this paper are: bayes-an
31
The categories of this paper are: ao-sci
25
The categories of this paper are: patt-sol
27
The categories of this paper are: comp-gas
32
The categories of this paper are: atom-ph
29
The categories of this paper are: funct-an