Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Vibrational density of states capture the role of dynamic allostery in
  protein evolution   Previous studies of the flexibilities of ancestral proteins suggests that
proteins evolve their function by altering their native state ensemble. Here we
propose a more direct method of visualizing this by measuring the changes in
the vibrational density of states (VDOS) of proteins as they evolve. Through
analysis of VDOS profiles of ancestral and extant proteins we observe that
$\beta$-lactamase and thioredoxins evolve by altering their density of states
in the terahertz region. Particularly, the shift in VDOS profiles between
ancestral and extant proteins suggests that nature utilize dynamic allostery
for functional evolution. Moreover, we also show that VDOS profile of
individual position can be used to describe the flexibility changes,
particularly those without any amino acid substitution.

35
The categories of this paper are: mtrl-th
22
The categories of this paper are: chao-dyn
21
The categories of this paper are: adap-org
6
The categories of this paper are: astro-ph
17
The categories of this paper are: q-fin
27
The categories of this paper are: comp-gas
11
The categories of this paper are: hep-lat
16
The categories of this paper are: stat
33
The categories of this paper are: plasm-ph
23
The categories of this paper are: solv-int
13
The categories of this paper are: quant-ph
20
The categories of this paper are: acc-phys
9
The categories of this paper are: nlin
8
The categories of this paper are: hep-ex
37
The categories of this paper are: supr-con
12
The categories of this paper are: nucl-th