Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Water influx is required for CD4+ T cell activation and T cell-dependent antibody responses Signaling from the T cell antigen receptor (TCR) on CD4+ T cells triggers the adaptive immune response by inducing T cell activation, proliferation, and differentiation. However, TCR signaling pathways are incompletely understood. Unexpectedly, we demonstrate that WNK1, a kinase previously implicated in osmoregulation in the kidney, is required for T-dependent antibody responses. We show that WNK1-OXSR1-STK39-dependent water influx through AQP3 is required for TCR signaling in CD4+ T cells and for entry into cell cycle. Additionally, by preventing ATR activation this signaling pathway is required for T cells to progress through the G2 phase of the cell cycle. Thus, TCR signaling via WNK1, OXSR1, STK39 and AQP3 leads to water entry that is essential for CD4+ T cell proliferation and hence T cell-dependent antibody responses.

One Sentence SummaryT cell antigen receptor signaling via the WNK1 kinase causes water entry which is essential for CD4+ T cell proliferation.
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The categories of this paper are: behavior
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The categories of this paper are: genomics
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The categories of this paper are: biophysics
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The categories of this paper are: bioinformatics
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The categories of this paper are: microbiology
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The categories of this paper are: synthetic
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The categories of this paper are: animal
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The categories of this paper are: scientific
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The categories of this paper are: paleontology
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The categories of this paper are: plant
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The categories of this paper are: epidemiology
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The categories of this paper are: cancer
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The categories of this paper are: zoology
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The categories of this paper are: bioengineering
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The categories of this paper are: evolutionary
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The categories of this paper are: biology