Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Shifting gears: Thermodynamics of genetic information storage suggest
  stress-dependence of mutation rate, which can accelerate adaptation   Background: Acceleration of adaptation dynamics by stress-induced
hypermutation has been found experimentally. Evolved evolvability is a
prominent explanation. We investigate a more generally applicable explanation
by a physical constraint. Methods and Results: A generic thermodynamical
analysis of genetic information storage obviates physical constraints on the
integrity of genetic information. The capability to employ metabolic resources
is found as a major determinant of mutation probability in stored genetic
information. Incorporation into a non-recombinant, asexual adaptation toy model
predicts cases of markedly accelerated adaptation, driven by a transient
increase of mutation rate. No change in the mutation rate as a genetic trait is
required. The mutation rate of one and the same genotype varies dependent on
stress level. Implications: Stress-dependent mutation rates are physically
necessary and challenge a condition-independent genotype to mutation rate
mapping. This holds implications for evolutionary theory and pathogen and
cancer evolution.

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The categories of this paper are: hep-ph
6
The categories of this paper are: astro-ph
8
The categories of this paper are: hep-ex
34
The categories of this paper are: chem-ph
24
The categories of this paper are: dg-ga
21
The categories of this paper are: adap-org
30
The categories of this paper are: q-alg
32
The categories of this paper are: atom-ph
20
The categories of this paper are: acc-phys
25
The categories of this paper are: patt-sol
23
The categories of this paper are: solv-int
27
The categories of this paper are: comp-gas
11
The categories of this paper are: hep-lat
26
The categories of this paper are: bayes-an
29
The categories of this paper are: funct-an
4
The categories of this paper are: cond-mat