Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Genomics-guided molecular maps of coronavirus targets in human cells: a
  path toward the repurposing of existing drugs to mitigate the pandemic   Human genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN,
were employed as baits to build genomics-guided maps of up-stream regulatory
elements, their expression and functions in human body, including
pathophysiologically-relevant cell types. Genes acting as repressors and
activators of the ACE2 and FURIN genes were identified based on the analyses of
gene silencing and overexpression experiments as well as relevant transgenic
mouse models. Panels of repressors (VDR; GATA5; SFTPC; HIF1a) and activators
(HMGA2; INSIG1) were then employed to identify existing drugs that could be
repurposed to mitigate the coronavirus infection. Present analyses identify
Vitamin D and Quercetin as promising pandemic mitigation agents. Gene
expression profiles of Vitamin D and Quercetin activities and their established
safety records as over-the-counter medicinal substances suggest that they may
represent viable candidates for further assessment and considerations of their
potential as coronavirus pandemic mitigation agents. Notably, gene set
enrichment analyses and expression profiling experiments identify multiple
drugs, most notably testosterone, dexamethasone, and doxorubicin, smoking, and
many disease conditions that appear to act as putative coronavirus
infection-promoting agents. Discordant patterns of Testosterone versus
Estradiol impacts on SCARS-CoV-2 targets suggest a plausible molecular
explanation of the apparently higher male mortality during coronavirus
pandemic.

31
The categories of this paper are: ao-sci
17
The categories of this paper are: q-fin
27
The categories of this paper are: comp-gas
18
The categories of this paper are: econ
32
The categories of this paper are: atom-ph
7
The categories of this paper are: hep-th
26
The categories of this paper are: bayes-an
28
The categories of this paper are: alg-geom
20
The categories of this paper are: acc-phys
36
The categories of this paper are: cmp-lg
14
The categories of this paper are: math-ph
12
The categories of this paper are: nucl-th
21
The categories of this paper are: adap-org
6
The categories of this paper are: astro-ph
29
The categories of this paper are: funct-an
4
The categories of this paper are: cond-mat