Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Modelling the effect of vascular status on tumour evolution and outcome
  after thermal therapy   Microscale oxygenation plays a prominent role in tumour progression.
Spatiotemporal variability of oxygen distribution in the tumour
microenvironment contributes to cellular heterogeneity and to the emergence of
normoxic and hypoxic populations. Local levels of oxygen strongly affect the
response of tumours to the administration of different therapeutic modalities
and, more generally, to the phenomenon of resistance to treatments. Several
interventions have been proposed to improve tumour oxygenation, being the
elevation of the local temperature (hyperthermia) an important one. While other
factors such as the metabolic activity have to be considered, the proficiency
of the tumour vascular system is a key factor both for the tissue oxygenation
and for its temperature maps. Consequently, the interplay of these factors has
attracted considerable attention from the mathematical modelling perspective.
Here we put forward a transport-based system of partial differential equations
aimed at describing the dynamics of healthy and tumour cell subpopulations at
the microscale in a region placed between two blood vessels. By using this
model with diverse flow conditions, we analyse the oxygen and temperature
profiles that arise in different scenarios of vascular status, both during free
progression and under thermal therapy. We find that low oxygen levels are
associated to elevations of temperature in locations preferentially populated
by hypoxic cells, and hyperthermia-induced cell death, being strongly dependent
on blood flow, would only appear under highly disrupted conditions of the local
vasculature. This results in a noticeable effect of heat on hypoxic cells.
Additionally, when pronounced cell death occurs, it is followed by a
significant increase in the oxygen levels.

19
The categories of this paper are: eess
0
The categories of this paper are: hep-ph
18
The categories of this paper are: econ
8
The categories of this paper are: hep-ex
36
The categories of this paper are: cmp-lg
7
The categories of this paper are: hep-th
1
The categories of this paper are: cs
33
The categories of this paper are: plasm-ph
15
The categories of this paper are: nucl-ex
12
The categories of this paper are: nucl-th
25
The categories of this paper are: patt-sol
5
The categories of this paper are: gr-qc
3
The categories of this paper are: physics
9
The categories of this paper are: nlin
27
The categories of this paper are: comp-gas
32
The categories of this paper are: atom-ph