Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Anti-fibrotic activity of an antimicrobial peptide in a Drosophila model. Fibrotic lesions accompany several pathological conditions including tumors. We show that expression of a dominant-active form of the Ras oncogene in Drosophila salivary glands (SGs) leads to redistribution of components of the basement membrane (BM) and fibrotic lesions. Similar to several types of mammalian fibrosis, the disturbed BM attracts clot components including insect transglutaminase and phenoloxidase. SG epithelial cells show reduced apico-basal polarity accompanied by a loss of secretory activity. Both the fibrotic lesions and the reduced cell polarity are alleviated by ectopic expression of the antimicrobial peptide Drosomycin (Drs), which also restores secretory activity of the SGs. In addition to ECM components, both Drs and F-actin localize to fibrotic lesions.
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The categories of this paper are: molecular
9
The categories of this paper are: synthetic
32
The categories of this paper are: zoology
6
The categories of this paper are: plant
12
The categories of this paper are: behavior
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The categories of this paper are: epidemiology
2
The categories of this paper are: biology
3
The categories of this paper are: evolutionary
21
The categories of this paper are: toxicology
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The categories of this paper are: pathology
29
The categories of this paper are: education
0
The categories of this paper are: genetics
31
The categories of this paper are: paleontology
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The categories of this paper are: systems
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The categories of this paper are: cell
4
The categories of this paper are: neuroscience