Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: Antigenic evolution of SARS-CoV-2 in immunocompromised hosts Prolonged infections of immunocompromised individuals have been proposed as a crucial source of new variants of SARS-CoV-2 during the COVID-19 pandemic. In principle, sustained within-host antigenic evolution in immunocompromised hosts could allow novel immune escape variants to emerge more rapidly, but little is known about how and when immunocompromised hosts play a critical role in pathogen evolution. Here, we use a simple mathematical model to understand the effects of immunocompromised hosts on the emergence of immune escape variants in the presence and absence of epistasis. We show that when the pathogen does not have to cross a fitness valley for immune escape to occur (no epistasis), immunocompromised individuals have no qualitative effect on antigenic evolution (although they may accelerate immune escape if within-host evolutionary dynamics are faster in immunocompromised individuals). But if a fitness valley exists between immune escape variants at the between-host level (epistasis), then persistent infections of immunocompromised individuals allow mutations to accumulate, therefore facilitating rather than simply speeding up antigenic evolution. Our results suggest that better genomic surveillance of infected immunocompromised individuals and better global health equality, including improving access to vaccines and treatments for individuals who are immunocompromised (especially in lower- and middle-income countries), may be crucial to preventing the emergence of future immune escape variants of SARS-CoV-2.

Lay SummaryWe study the role that immunocompromised individuals may play in the evolution of novel variants of the coronavirus responsible for the COVID-19 pandemic. We show that immunocompromised hosts can be crucial for the evolution of immune escape variants. Targeted treatment and surveillance may therefore prevent the emergence of new variants.
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The categories of this paper are: ethics
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The categories of this paper are: critical
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The categories of this paper are: public
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The categories of this paper are: genomic
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The categories of this paper are: reproductive
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The categories of this paper are: genetic
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The categories of this paper are: rheumatology
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The categories of this paper are: improvement
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The categories of this paper are: oral
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The categories of this paper are: respiratory
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The categories of this paper are: obstetrics
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The categories of this paper are: medicine
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The categories of this paper are: orthopedics
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The categories of this paper are: informatics
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The categories of this paper are: environmental
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The categories of this paper are: nursing