Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Optimizing adaptive cancer therapy: dynamic programming and evolutionary
  game theory   Recent clinical trials have shown that the adaptive drug therapy can be more
efficient than a standard MTD-based policy in treatment of cancer patients. The
adaptive therapy paradigm is not based on a preset schedule; instead, the doses
are administered based on the current state of tumor. But the adaptive
treatment policies examined so far have been largely ad hoc. In this paper we
propose a method for systematically optimizing the rules of adaptive policies
based on an Evolutionary Game Theory model of cancer dynamics. Given a set of
treatment objectives, we use the framework of dynamic programming to find the
optimal treatment strategies. In particular, we optimize the total drug usage
and time to recovery by solving a Hamilton-Jacobi-Bellman equation based on a
mathematical model of tumor evolution. We compare adaptive/optimal treatment
strategy with MTD-based treatment policy. We show that optimal treatment
strategies can dramatically decrease the total amount of drugs prescribed as
well as increase the fraction of initial tumour states from which the recovery
is possible. We also examine the optimization trade-offs between the total
administered drugs and recovery time. The adaptive therapy combined with
optimal control theory is a promising concept in the cancer treatment and
should be integrated into clinical trial design.

2
The categories of this paper are: math
4
The categories of this paper are: cond-mat
20
The categories of this paper are: acc-phys
6
The categories of this paper are: astro-ph
30
The categories of this paper are: q-alg
0
The categories of this paper are: hep-ph
9
The categories of this paper are: nlin
29
The categories of this paper are: funct-an
28
The categories of this paper are: alg-geom
1
The categories of this paper are: cs
17
The categories of this paper are: q-fin
14
The categories of this paper are: math-ph
19
The categories of this paper are: eess
11
The categories of this paper are: hep-lat
33
The categories of this paper are: plasm-ph
22
The categories of this paper are: chao-dyn