Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Translocation of structured polynucleotides through nanopores   We investigate theoretically the translocation of structured RNA/DNA
molecules through narrow pores which allow single but not double strands to
pass. The unzipping of basepaired regions within the molecules presents
significant kinetic barriers for the translocation process. We show that this
circumstance may be exploited to determine the full basepairing pattern of
polynucleotides, including RNA pseudoknots. The crucial requirement is that the
translocation dynamics (i.e., the length of the translocated molecular segment)
needs to be recorded as a function of time with a spatial resolution of a few
nucleotides. This could be achieved, for instance, by applying a mechanical
driving force for translocation and recording force-extension curves (FEC's)
with a device such as an atomic force microscope or optical tweezers. Our
analysis suggests that with this added spatial resolution, nanopores could be
transformed into a powerful experimental tool to study the folding of nucleic
acids.

24
The categories of this paper are: dg-ga
2
The categories of this paper are: math
28
The categories of this paper are: alg-geom
12
The categories of this paper are: nucl-th
34
The categories of this paper are: chem-ph
11
The categories of this paper are: hep-lat
15
The categories of this paper are: nucl-ex
20
The categories of this paper are: acc-phys
26
The categories of this paper are: bayes-an
17
The categories of this paper are: q-fin
23
The categories of this paper are: solv-int
25
The categories of this paper are: patt-sol
6
The categories of this paper are: astro-ph
8
The categories of this paper are: hep-ex
19
The categories of this paper are: eess
30
The categories of this paper are: q-alg