Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Free Energy Self-Averaging in Protein-Sized Random Heteropolymers   Current theories of heteropolymers are inherently macrpscopic, but are
applied to folding proteins which are only mesoscopic. In these theories, one
computes the averaged free energy over sequences, always assuming that it is
self-averaging -- a property well-established only if a system with quenched
disorder is macroscopic. By enumerating the states and energies of compact 18,
27, and 36mers on a simplified lattice model with an ensemble of random
sequences, we test the validity of the self-averaging approximation. We find
that fluctuations in the free energy between sequences are weak, and that
self-averaging is a valid approximation at the length scale of real proteins.
These results validate certain sequence design methods which can exponentially
speed up computational design and greatly simplify experimental realizations.

0
The categories of this paper are: hep-ph
25
The categories of this paper are: patt-sol
3
The categories of this paper are: physics
16
The categories of this paper are: stat
13
The categories of this paper are: quant-ph
36
The categories of this paper are: cmp-lg
7
The categories of this paper are: hep-th
30
The categories of this paper are: q-alg
5
The categories of this paper are: gr-qc
26
The categories of this paper are: bayes-an
29
The categories of this paper are: funct-an
11
The categories of this paper are: hep-lat
20
The categories of this paper are: acc-phys
34
The categories of this paper are: chem-ph
6
The categories of this paper are: astro-ph
1
The categories of this paper are: cs