I would recommend these for larger runners
930928
I ran my first miles in these last night and was impressed.  At 235 lbs. it's hard to find a running shoe.  I would recommend these for larger runners.  I'm not sure how well they will hold up, but my first impression is a good one.  Ordered the same size as my Nano 4.0's
4101774
I was suffering from mild shin splints while training for a half marathon. I couldn't be out of commission! I ordered these and hoped they would work.
These combined with slowing my speed worked wonders. I thought they were a little big even though I got a medium and I was at the high end of a medium according to the size chart. But I found out they are supposed to be tighter towards the bottom and become slightly looser as they go up the leg. I put these on about a half hour before I leave for a run. I can feel the difference in my legs after about 15 minutes.
I am always weary about buying products like this, but I can say these truly work for me. And the price was unbeatable!
669502
I just bought a pair of the Brooks Glycerine 10 and they fit like a glove. I'd been using Brooks Ghost 5, which I also really like and would highly recommend, but I wanted to try a new model. There's quite a bit more cushion in the Glycerine 10 and that's great for absorbing the shock of road runs. They are also stable, which is helpful on the trail. I am 5'11" about 160lbs and run 15 - 25 mi/week. I have a neutral somewhat over-pronating running style. These shoes work great for me. My only complaint is the $140 price tag and that's the main reason I wouldn't give them 5 stars. On the upside I am looking to eek out 300-500 miles in them so hopefully they'll be worth it in the proverbial long run.
383026
I put these on a today's deal. They're very good weight with good support , and are not too thick for running shoes. They also stay up well. My son is a cross country runner, and these have served him well.
3962189
Very comfortable and would recommend them.
4854707
I was careful to try and buy the size that fit me the best and this shoe is pretty good.  I don't think it's the best running shoe for cushioning when you run but I think the cost is worth it.
483922
I purchased these to replace my Nike Equalon 4s, which I had worn down to the bone.

For reference, I am a tall/big runner with flat feet, moderate to severe over pronation, and a midfoot strike.

The Kayanos run faster but have noticeably less cushioning and stability features than the Equalons. At first I had a bit of trepidation regarding the lack of support, but after a few runs I've found that the Kayanos still do a very adequate job of protecting me. I'm just getting back into running after a significant foot injury, and even with being quite out of shape, I've suffered no ill effects or straining from any of my runs so far. The fact that they are lighter and faster overall is a definite plus as well.

These run a bit narrower than my Equalons did, but that may just be an Asics thing.

Overall, I am very happy with these shoes thus far. For around $90, you would be hard-pressed to find a better performing running shoe.
3423543
As a bigger runner (6'4", 215), I first tried other shoes-got a sore knee-and hit up my local expert running shop.  Said shop determined I required a shoe with neutral support and put me on a treadmill to tape my stride.  I am currently on my second pair of D-3s (traded the first out after 300 miles) and would strongly suggest trading them out maybe around 250 miles.  I'm far from the most graceful runner, but the D-3 really gave me the support and cushioning required to keep me moving.  As I utilize Nike's nikeplus system but aren't able to get the support from Nike's shoes, I simply purchased&nbsp;<a data-hook="product-link-linked" class="a-link-normal" href="/The-Original-Shoe-Pouch-for-Nike-iPod-Assorted-Colors/dp/B000UGLIXC/ref=cm_cr_arp_d_rvw_txt?ie=UTF8">The Original Shoe Pouch for Nike + iPod, Assorted Colors</a>&nbsp;for the transmitter and have experienced no issues.  My feet tend to be on the narrow side and my arch is slightly higher than average.  Great enough shoes that I have three waiting in the closet for when I'm done with my current pair.  I knocked the score down one star because I hoped I could get more than 300 out of them.  Each week sees me running about 20-30 miles.
915227
Just started running again. Had an evaluation at a local high end shoes store and discovered that these would work best for my running style. Ordered them on Amazon upon finding them 40% less than retail. I was a little baffled when they recommend that I purchase them a whole size larger than my normal shoe, but after getting them i understand why. I was worried about foot sliding around in shoe, but they fit great and provide the support I need.
778511
I went without them for an 18 mile long run and ran over 30 seconds/mile slower than without them.  My legs were "dead" and very heavy.  I wore them for a 25K race last week and beat my personal best. I was not sore and the weather was in the 50's F and were very comfortable.  I have a half marathon this weekend with high 60's projected temp.  Going to wear them and see how they feel in warmer weather.  My favorite running temp is the 30's so we will see how it goes.
3193994
These are a life saver for me whenever I am running more the 8 miles.
1256279
This is the second pair of this style that I purchased, so I do recommend them.  I would like a bit more padding, but the shoe is quite comfortable for walking my 3-5 miles a day on an indoor track.  I don't know whether they would be equally comfortable for running, or how they perform on pavement.  I like that they come in a variety of colors and that they have an adequate number of eyes for the laces to fit snugly or to adjust.
1833849
I am pretty sure I could run in these shoes for hours without a problem. So far, they are excellent shoes. I ordered them on a whim; I normally wear Nikes, but my running trainer recommended a sturdier, running-specific shoe. I am very skeptical of brands I haven't tried before, but Amazon had them on sale after Christmas, and my year-old generic Nike trainers were starting to wear down.

These meet all of my needs: good arch support, good stability, and a secure, light fit while providing excellent cushioning. These are light shoes, but they are substantial: When my foot strikes the pavement, my body doesn't feel jarred and I don't feel body aches/fatigue as much because these truly provide excellent cushioning. I was starting to have a lot of problems with my ankles because my other shoes were wearing out. Since I've been wearing these, I don't have any ankle/knee/hip pain after my long runs of 6-10 miles. I run in these about 20 miles a week and so far, they are the  best running shoes I've ever owned.

In women's dress shoes/boots, I wear a 6.5. In Nike running shoes, I wear a 7. I ordered these in a 7.5 and they fit nicely. I'm glad I ordered up a size - you might want to, too.
3086396
Prompt shipping.  I got the large and they fit very snug. I am 5'7" and 155 lbs.

Highly recommend these for running:)
942156
Sometimes I wear large, sometimes medium.  I decided to go with the large and they fit really well. Comfortable and after using them for a few runs I've decided to get a few more.
3867255
I just began running again and I really like these shoes.  I am about 40 pounds overweight and tend to step on my heels.  I have not had any pain with these shoes.  I have had no blisters.  There was no breaking in period for these.  They are not heavy and breath well.
4355952
I am a tall female runner (6'0 and 135 lbs) and support for my knees and hamstrings is a must.  I wear a medium and they are TIGHT in a good way, allowing for my range of motion but keeping muscles and joints well supported.  I run 20 to 30 miles weekly and wear these on runs over 4 miles and for an hour or two post-run.  I love them; they feel good and they are super flattering!