There's a huge difference, for example, between smoking marijuana and smoking heroin and between communicating to an 8-year-old or a 14-year-old.
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There is a huge difference between smoking marijuana and smoking heroin, and there is a huge difference between communicating to an 8-year-old or a 14-year-old.
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There is no practical difference between communicating to an 8-year-old or a 14-year-old.