what does sickle cell anemia cause?
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In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. Both mother and father must pass the defective form of the gene for a child to be affected.
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Sickle Cell Anemia – The Most Common Hemoglobin Disease Sickle cell anemia affects about 90,000 to 100,000 people in the United States, including one in every 500 African-American babies and one in every 36,000 Hispanic babies. Sickle cell anemia can cause pain, infections and damage to body organs.
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Many of the complications or health problems caused by sickle cell disease are caused by organ damage or inflammation. Sickle cells also die sooner than normal red blood cells. Not having enough healthy red blood cells causes anemia, which can make you feel tired or weak because there is less oxygen in your body.
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['Stroke. Sickle cells can block blood flow to an area of your brain. ... ', 'Acute chest syndrome. ... ', 'Pulmonary hypertension. ... ', 'Organ damage. ... ', 'Blindness. ... ', 'Leg ulcers. ... ', 'Gallstones. ... ', 'Priapism.']
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People with sickle cell disease have red blood cells that contain mostly hemoglobin S, an abnormal hemoglobin type. These red blood cells are stiff, distorted in shape (like a sickle) and sometimes block small blood vessels.
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Children with sickle cell disease usually grow and develop more slowly, even reaching puberty later than their peers. This growth delay is caused by having fewer red blood cells. Adults with sickle cell disease are also typically shorter and thinner than the general population.
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Additionally, in individuals with the genetic defect, the painful sickle cell crisis can be precipitated by certain medical and environmental factors including infection, bleeding, exposure to cold weather, leg ulcers, and blockage of the blood vessels.
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Sickle cell anemia is a disorder of the red blood cells which causes blood vessels to become blocked. Sickle cell anemia in pregnant women can cause complications including premature birth or miscarriage. The risk of the baby inheriting the disease is increased if both parents carry the gene.
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Sickle cell anemia can lead to a wide range of complications that may require treatment. Some examples include: hearing loss, vision problems, acute chest syndrome, jaundice, priapism (persistent and painful erections), leg ulcers, gallstones, and stroke.
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Sickle Cell Disease and Sickle Cell Anaemia. Sickle cell disease (SCD) is a serious, inherited condition affecting the blood and various organs in the body. It affects the red blood cells, causing episodes of sickling, which produce episodes of pain and other symptoms.
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Sickle cell anemia is caused when a baby gets one sickle cell gene change from each parent. Hemoglobin SC. This condition is caused when a baby gets one sickle cell gene change from one parent and one gene change for hemoglobin C (another abnormal type of hemoglobin) from the other parent.
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A case study of the effects of mutation: Sickle cell anemia. Sickle cell anemia is a genetic disease with severe symptoms, including pain and anemia. The disease is caused by a mutated version of the gene that helps make hemoglobin — a protein that carries oxygen in red blood cells.
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The leading causes of death in sickle cell diseases (SCD) are infection, pain episodes, acute chest syndrome and stroke [1, 2]. Death can be sudden and unexpected in sickle cell anaemia [1]. Vaso-occlusive crisis is one of the commonest presentations and a leading cause of death [3].
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Sickle cell anemia is one of a group of diseases termed hemoglobinopathies, in which hemoglobin A is partly or completely replaced by abnormal sickle hemoglobin S. It is caused by the inheritance of a gene for a structurally abnormal portion of the hemoglobin chain.
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Sickle Cell disease is an autosomal recessive disorder that causes anemia, joint pain, a swollen spleen, and frequent, severe infections. It illustrates balanced polymorphism because carriers are resistant to malaria, an infection by the parasite Plasmodium falciparum that causes cycles of chills and fever.
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['Anemia. Sickle cells break apart easily and die, leaving you with too few red blood cells. ... ', 'Episodes of pain. ... ', 'Swelling of hands and feet. ... ', 'Frequent infections. ... ', 'Delayed growth or puberty. ... ', 'Vision problems.']
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Abnormal versions of beta-globin can distort red blood cells into a sickle shape. The sickle-shaped red blood cells die prematurely, which can lead to anemia. Sometimes the inflexible, sickle-shaped cells get stuck in small blood vessels and can cause serious medical complications.