are wbc elevated in cll?
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People with CLL may have very high white blood cell counts because of excess numbers of lymphocytes (lymphocytosis), but the leukemia cells don't fight infection the way normal white blood cells do.
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Stress reaction can cause a high count, and certain drugs, especially steroids, can lead to a higher number. On the other hand, several cancers, such as leukemia, can also show many white blood cells. A doctor should evaluate any higher than normal white blood cell count.
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Abnormal levels of white blood cells and abnormally low red blood cell or platelet counts can also indicate leukemia. If you test positive for leukemia, your doctor will perform a biopsy of your bone marrow to determine which type you have.
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Background: It is reported that the percentage of smudge cells in the blood smear could be a prognostic indicator in chronic lymphocytic leukemia. However, the clinical significance of smudge cells in other hematological malignancies, solid tumors or non-malignant diseases is less clear.
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High-risk ALL more than 50,000 white blood cells/mm3 of blood when they are diagnosed. More than 5 leukemic cells in the CSF (CNS 3) leukemia cells with chromosome changes that are more difficult to treat. testicular involvement. steroids given before diagnosis of leukemia.
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They can develop when lymphocytes (a type of white blood cell that fights infection) grow out of control. CLL has 'leukaemia' in its name because it affects the blood. SLL is another form of the same disease and it mainly affects the lymph nodes (glands), which is why it is called a 'lymphoma'.
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Within the context of HIV, an elevated WBC typically means that your body is actively fighting an infection, the symptoms of which may or may not be evident.
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Though multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) have overlapping epidemiologic features and originate from mature B cells, the simultaneous occurrence of both cancers is rare, and data on clinical outcomes and the management of these concurrent disease are limited.
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Risk factors Factors that may increase the risk of acute lymphocytic leukemia include: Previous cancer treatment. Children and adults who've had certain types of chemotherapy and radiation therapy for other kinds of cancer may have an increased risk of developing acute lymphocytic leukemia.
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However, people with leukocytosis may also experience a combination of these symptoms: fever, fainting, bleeding, bruising, weight loss, and general pain. What are the causes of elevated white blood cell count?
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At the time of diagnosis, patients can have very, very high white blood cell counts. Typically a healthy person has a white blood cell count of about 4,000-11,000. Patients with acute or even chronic leukemia may come in with a white blood cell count up into the 100,000-400,000 range.
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A white blood cell (WBC) count measures the number of white blood cells in your blood, and a WBC differential determines the percentage of each type of white blood cell present in your blood. A differential can also detect immature white blood cells and abnormalities, both of which are signs of potential issues.
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Cellulitis is usually diagnosed based on its appearance. Sometimes doctors will check a person's blood count to see if the white blood cells are elevated (meaning that the immune system is fighting an infection). That said, an elevated white blood cell count may not occur in the early stages of an infection.
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People with HL can sometimes have abnormal blood counts. For example, if the lymphoma invades the bone marrow (where new blood cells are made) a person might have anemia (not enough red blood cells). A high white blood cell count is another possible sign of HL, although it can also be caused by infection.
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The WBC count becomes elevated in approximately 70-90% of patients with acute appendicitis. However, the WBC count is elevated in many other abdominal conditions, as well. Furthermore, the WBC count is often within the reference range within the first 24 hours of symptoms.
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Another symptom of CLL progression is extreme fatigue and shortness of breath while doing your normal day-to-day activities. This is due to fewer healthy red blood cells and more cancer cells accumulating in your body.
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Bacteria or yeast may be observed on peripheral blood smears and may lead to spuriously elevated platelet counts. They have been reported to disturb the white blood cell (WBC) differential count if they clumped together, and a large number of such microorganisms have been shown to increase WBC counts.