how long has acyclovir been around?
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Abstract. A screening program for antiviral drugs begun at Burroughs Wellcome in the 1960s resulted in the discovery of acyclovir in 1974. Preclinical investigation brought the drug to clinical trials in 1977 and the first form of the drug (topical) was available to physicians in 1982.
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Acyclovir cream is used to treat cold sores (fever blisters; blisters that are caused by a virus called herpes simplex) on the face or lips.
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Conclusion: Valacyclovir appear to be somewhat better than famciclovir for suppression of genital herpes and associated shedding. Further comparative trials of antiviral drugs for various indications should be performed as acyclovir and penciclovir appear to have different ability to abrogate HSV reactivation.
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Acyclovir topical (for the skin) is an antiviral medicine that is used to treat skin symptoms caused by the herpes virus. Acyclovir topical cream is used to treat cold sores on the lips and face. Acyclovir topical ointment is used to treat genital herpes lesions.
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Aciclovir Tablets are indicated for the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes (excluding neonatal HSV and severe HSV infections in immunocompromised children).
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Aciclovir will not stop your contraception working. This includes the combined pill and emergency contraception. But if aciclovir makes you get sick or have severe diarrhoea (6 to 8 watery poos in 24 hours) for more than 24 hours, your contraceptive pills may not protect you from pregnancy.
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Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body. Acyclovir will not cure genital herpes and may not stop the spread of genital herpes to other people.
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May take up to two hours to reach peak plasma concentrations after oral acyclovir administration. May take up to three days for symptom reduction; however, acyclovir should be taken until the course prescribed is completed. Acyclovir works best when started within 48 hours of symptom onset.
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Genital herpes outbreaks may be treated for 3–5 days with oral antiviral drugs, including acyclovir (ACV), valacyclovir (Valtrex; GlaxoSmithKline), and famciclovir (Famvir; Novartis), but treatment only decreases the duration of symptoms by approximately one-quarter [3, 4].
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Acyclovir is a safe treatment that reduces the duration and severity of chickenpox in normal children when therapy is initiated during the first 24 hours of rash. Whether treatment with acyclovir can reduce the rare, serious complications of chickenpox remains uncertain.
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The vaccine finally received approval from the US Food and Drug Administration in 2006. It was first marketed by US pharmaceutical company Merck & Co under the trade name Gardasil.
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Your doctor may prescribe: Acyclovir (Zovirax) Famciclovir (Famvir) Valacyclovir (Valtrex)
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Valacyclovir comes as a tablet to take by mouth. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days.
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The therapeutic potential of acyclovir is limited by the low oral bioavailability owing to its limited aqueous solubility and low permeability.
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About Aciclovir. Aciclovir is an antiviral medication used to treat infection caused by the herpes virus, including cold sores, genital herpes, chicken pox and shingles. It is available on prescription as an oral medication, or as a topical cream which can be bought over the counter, prescription-free.
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Acyclovir ointment is used to treat first outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time) and to treat certain types of sores caused by the herpes simplex virus in people with weak immune systems.