which antidepressant has the shortest half life?
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Fluoxetine, which has the longest half-life of the SSRIs (see Table 1), appears to produce the fewest withdrawal symptoms, while paroxetine, which has the shortest half-life, produces the most pronounced discontinuation effects.
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["Paxil (paroxetine) Prescription only. 52% of people say it's worth it. ... ", '6 alternatives.', 'Celexa (citalopram) Prescription only. ... ', 'Lexapro (escitalopram) Prescription only. ... ', 'Prozac (fluoxetine) Prescription only. ... ', 'Zoloft (sertraline) Prescription only. ... ', 'Cymbalta (duloxetine) Prescription only. ... ', 'Effexor (venlafaxine) Prescription only.']
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Symptoms of antidepressant discontinuation syndrome tend to be mild. They usually start within two to four days, and last just a week or two.
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Symptoms most often occur within three days of stopping the antidepressant. They are usually mild and go away within about two weeks.
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Zoloft (sertraline) has a half-life of 24 to 26 hours, which means that it will take a person roughly a day for the drug's presence to reduce to half the amount. In another 24 hours, the amount in a person's body will decrease to 25% or half of the remaining amount.
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['Amitriptyline.', 'Effexor (venlafaxine)', 'Lexapro (escitalopram)', 'Paxil (paroxetine)', 'Remeron (mirtazapine)', 'Trintellix (vortioxetine)']
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Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants.
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Zoloft has a half-life of about one day. That means that for every day that passes without taking the medication, the level in the blood falls by 50 percent. After one day, the level is reduced to 50 percent of the original level, after two days to 25 percent, after three days to 12.5 percent, and so on.
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Citalopram and sertraline, which have relatively little effect on the P450 system and wash out of the body relatively quickly, are the least likely of the SSRIs to interact with a replacement drug.
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Fluoxetine may be taken with or without food. Fluoxetine (Sarafem) comes as a capsule to take by mouth. Fluoxetine (Prozac) capsules, tablets, and liquid are usually taken once a day in the morning or twice a day in the morning and at noon. Fluoxetine delayed-released capsules are usually taken once a week.
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Half-Life Of Escitalopram (Lexapro) While medications with a short half-life can leave a person's body within two days, medications with a longer half-life can take up to four weeks to leave a person's body. Lexapro's half-life is 27 to 32 hours.
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SSRIs include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil, Pexeva), sertraline (Zoloft) and vilazodone (Viibryd). Serotonin-norepinephrine reuptake inhibitors (SNRIs).
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Most medications have a half-life of about 24 hours, so they are gone — or close to it — in 4-5 days.
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The popular antidepressant also may have edged out Meridia, producing an average weight loss of slightly more than 11 pounds in patients taking Prozac for 24 to 30 weeks, compared with less than 10 pounds shed after 26 weeks by those using Meridia.
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It can take up to six weeks after the first dose of medication before it has an antidepressant effect. For some people it can take up to eight weeks or a little longer before they start to feel better, and the maximum benefit is felt after six months. Antidepressant medication is generally very effective.
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SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline. [16] These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.
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Tricyclic antidepressants are used to treat depression and some other conditions. They often take 2-4 weeks to work fully. A normal course of antidepressants lasts at least six months after symptoms have eased. Side-effects may occur but are often minor and may ease off.