cytotoxic t cells are important for controlling?
242161
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells represent two distinct but related lineages that are important for the control of viral, bacterial, and parasitic infections. These cells also play a prominent and complementary role in the sensing and elimination of malignant cells.
838241
To activate a cytotoxic or helper T cell to proliferate and differentiate into an effector cell, an antigen-presenting cell provides two kinds of signals. ... This peptide-MHC complex signals through the T cell receptor and its associated proteins.
148504
These distinct approaches of target recognition allow for complementary functions, with CTLs being specialized in detecting cancer cells or those infected with intracellular pathogens, such as viruses, whereas a prominent function of NK cells is to eliminate those cells where the pathogen or oncogene has blocked ...
868694
Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated. The key players of adaptive cellular immune responses are T lymphocytes in general and, for the effector function, cytotoxic T lymphocytes (CTLs) in particular.
1082106
At their surface they have a membrane receptor complementary to the antigen of the tumor cells that are to be eliminated. Alerted by the presence of this antigen, the T cells are activated, and then identify and bind to infectious or tumor cells, before delivering into them a fatal load of enzymes.
2492
Cytotoxic CD8 T cells carry out their killing function by releasing two types of preformed cytotoxic protein: the granzymes, which seem able to induce apoptosis in any type of target cell, and the pore-forming protein perforin, which punches holes in the target-cell membrane through which the granzymes can enter.
771027
Most cells in the body can present antigen to CD8+ cytotoxic T cells via MHC class I; however, the term "antigen-presenting cell" is often used specifically to describe professional APCs. Such cells express MHC class I and MHC class II molecules and can stimulate CD4+ helper T cells as well as cytotoxic T cells.
715510
T cells are so called because they are predominantly produced in the thymus. ... As the names suggest helper T cells 'help' other cells of the immune system, whilst cytotoxic T cells kill virally infected cells and tumours. Unlike antibody, the TCR cannot bind antigen directly.
1054632
Which statement best describes the difference in responses of effector B cells (plasma cells) and cytotoxic T cells? B cells secrete antibodies against a pathogen; cytotoxic T cells kill pathogen-infected host cells.
318140
MHC restriction is significant for T cells to function properly when it leaves the thymus because it allows T cell receptors to bind to MHC and detect cells that are infected by intracellular pathogens, viral proteins and bearing genetic defects.
113454
Abstract. Natural killer (NK) cells target and kill aberrant cells, such as virally infected and tumorigenic cells. Killing is mediated by cytotoxic molecules which are stored within secretory lysosomes, a specialized exocytic organelle found in NK cells.
440171
T cells function as the central orchestrator of both innate and adaptive immune responses. They are also responsible for destruction of cells infected with intracellular pathogens. The targeting and destruction of intracellular pathogens by T cells is called cell-mediated immunity, or cellular immunity. Figure 18.1.
520488
Cytotoxic T cells kill target cells bearing specific antigen while sparing neighboring uninfected cells. All the cells in a tissue are susceptible to lysis by the cytotoxic proteins of armed effector CD8 T cells, but only infected cells are killed.
917843
The T and NK cells in patients with primary, or familial, HLH can't kill virus-infected or other abnormal cells in the patient's body like they normally would. T cells and NK cells normally do this by secreting death signals into targeted abnormal cells.
460412
Natural killer (NK) cells target and kill aberrant cells, such as virally infected and tumorigenic cells. Killing is mediated by cytotoxic molecules which are stored within secretory lysosomes, a specialized exocytic organelle found in NK cells.
1409030
1 T helper cells. T helper cells assist other leukocytes in immunologic processes, including maturation of B cells into plasma cells and memory B cells, and activate cytotoxic T cells and macrophagic cells. They are not cytotoxic or phagocytic, but are vital for immune response.
453033
The central physiological function of the cytotoxic T lymphocyte (CTL) is to eliminate cells that express abnormal surface phenotype as a result of intrinsic changes within the cell. It would obviously be deleterious if, for instance, CTL are to destroy antigen processing cells essential for the antibody response.