is amyotrophic lateral sclerosis motor neuron disease?
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Amyotrophic Lateral Sclerosis (ALS), Progressive Muscular Atrophy (PMA), Progressive Bulbar Palsy (PBP) and Primary Lateral Sclerosis (PLS) are all subtypes of motor neurone disease.
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About 5 to 10 percent of all ALS cases are familial, which means that an individual inherits the disease from his or her parents. The familial form of ALS usually only requires one parent to carry the gene responsible for the disease. Mutations in more than a dozen genes have been found to cause familial ALS.
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Many people may have mild symptoms for years with periods of remission. In contrast, ALS destroys the nerve cells (neurons) so that the body cannot communicate with the brain. Symptoms of ALS progress continually, and result in paralysis, and death a few years after the initial diagnosis.
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ALS is not considered an autoimmune disease, although some researchers theorize that it might be, due in part, to a disorganized immune response. Hereditary factors such as genes are thought to play a significant role in some patients because about one of every 10 patients has inherited the disease.
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While Muscular Dystrophy and ALS are two distinct diseases, they are both neurodegenerative, and lead to similar patient outcomes. They are also the focus of intensive research and drug development to improve symptoms and lifespan.
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The upper motor neuron syndrome signs are seen in conditions where motor areas in the brain and/or spinal cord are damaged or fail to develop normally. These include spinal cord injury, cerebral palsy, multiple sclerosis and acquired brain injury including stroke.
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Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat that encodes an abnormally long polyglutamine stretch in the disease protein huntingtin [39]. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that occurs sporadically or as a familial disorder.
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Currently, there is no cure for ALS and no effective treatment to halt, or reverse, the progression of the disease. ALS belongs to a wider group of disorders known as motor neuron diseases, which are caused by gradual deterioration (degeneration) and death of motor neurons.
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Lou Gehrig's disease is a disorder that's also called amyotrophic lateral sclerosis (say: ah-my-uh-TRO-fik LA-tuh-rul skluh-RO-sis), or ALS. The official name comes from these Greek words: "a" for without. "myo" for muscle.
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Amyotrophic lateral sclerosis (ALS) is a group of rare neurological diseases that mainly involve the nerve cells (neurons) responsible for controlling voluntary muscle movement. Voluntary muscles produce movements like chewing, walking, and talking. The disease is progressive, meaning the symptoms get worse over time.
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Disease localizing to the spinal cord is a well-known ALS mimic, and 4 of our patients had structural spinal pathology identified. This included spinal stenosis in 3 cases and a symptomatic spinal cyst in another.
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There's no cure for motor neurone disease, but treatment can help reduce the impact the symptoms have on your life. You'll be cared for by a team of specialists and a GP.
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Although both upper and motor neuron lesions result in muscle weakness, they are clinically distinct due to various other manifestations. Unlike UMNs, LMN lesions present with muscle atrophy, fasciculations (muscle twitching), decreased reflexes, decreased tone, negative Babinsky sign, and flaccid paralysis.
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The study, published in the journal Annals of Neurology, confirmed that colorful carotenoids prevented the onset of ALS, while diets high in lycopene, beta-cryptoxanthin, and vitamin C did not decrease ALS risk.
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Survival rates Motor neurone disease is a severely life-shortening condition for most people. Life expectancy for about half of those with the condition is three years from the start of symptoms. However, some people may live for up to 10 years, and in rarer circumstances even longer.
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Muscular dystrophy (MD) is a group of genetic disorders that gradually weakens and damages the muscles. Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that disrupts communication between the brain and body and within the brain itself.
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About motor neurone disease This leads to muscle weakness, often with visible wasting. Motor neurone disease, also known as amyotrophic lateral sclerosis (ALS), occurs when specialist nerve cells in the brain and spinal cord called motor neurones stop working properly.