is medullary sponge kidney genetic?
243260
The exact cause of Medullary Sponge Kidney is not known and most cases occur sporadically for no apparent reason. Some cases are thought to run in families (familial) and may be inherited as an autosomal dominant genetic trait. However, this inheritance pattern has not been proven.
679012
The renal complications in sickle cell disease originate from the occluded vessels (vasa recta) in the renal medulla, given the low partial pressure of oxygen (10 to 35 mm Hg), acidosis, and high osmolarity, which predisposes to hemoglobin S tetramerization and subsequent sickling of the erythrocytes.
1425711
These include illnesses like diabetes or high blood pressure, inflammation and a range of inherited conditions. Deficiency or excess in key minerals like calcium and phosphorous, electrolyte imbalances like sodium and potassium, dehydration and fluid retention can all have their genesis in the kidneys.
1434686
The renal column (or Bertin column, or column of Bertin) is a medullary extension of the renal cortex in between the renal pyramids. It allows the cortex to be better anchored. Each column consists of lines of blood vessels and urinary tubes and a fibrous material.
1039821
The cortex and medulla make up two of the internal layers of a kidney and are composed of individual filtering units known as nephrons.
291097
Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large.
87133
The animal organ, probably from a pig or baboon could be genetically altered with human genes to trick a patient's immune system into accepting it as a part of its own body. They have re-emerged because of the lack of organs available and the constant battle to keep immune systems from rejecting allotransplants.
915506
Only recently have detailed investigations into drug metabolism in the kidney been carried out. These studies have shown that the kidney is meta-bolically very active in effecting the biotransformation of a variety of chemicals and drugs and, in some cases, surpasses the liver.
1269232
Simple sponges provide clues to origin of nervous system. Sponges are among the most primitive of all animals. They are immobile, and live by filtering detritus from the water. They have no brains or, for that matter, any neurons, organs or even tissues.
1320053
Abnormal genes cause polycystic kidney disease, which means that in most cases, the disease runs in families. Rarely, a genetic mutation occurs on its own (spontaneous), so that neither parent has a copy of the mutated gene.
621054
Abstract. The pathogenesis of renal potassium wasting and hypokalemia in classic renal tubular acidosis (type 1 RTA) remains uncertain. The prevailing theory is that K(+)-Na+ exchange is stimulated due to an inability of the distal tubule to establish a normal steep lumen-peritubular H+ gradient.
1063799
The renal cortex, renal medulla, and renal pelvis are the three main internal regions found in a kidney. Nephrons, masses of tiny tubules, are largely located in the medulla and receive fluid from the blood vessels in the renal cortex.
1033258
['bladder or kidney stones.', "glomerulonephritis, an inflammation of the kidneys' filtering system.", 'bladder or kidney cancer.', 'kidney injury, such as from a fall or vehicle accident.', 'inherited disorders, such as Alport syndrome or sickle cell anemia.']
713753
The renal cortex is a space between the medulla and the outer capsule. The renal medulla contains the majority of the length of nephrons, the main functional component of the kidney that filters fluid from blood. The renal pelvis connects the kidney with the circulatory and nervous systems from the rest of the body.
594757
Having three kidneys is rare, with fewer than 100 cases reported in the medical literature, according to a 2013 report of a similar case published in The Internet Journal of Radiology. The condition is thought to arise during embryonic development, when a structure that typically forms a single kidney splits in two.
16544
The size of the kidney depends on body size. A normal adult male kidney will be at least 11 centimeters long. A normal adult female kidney will be at least 10 centimeters long. The right kidney is often just slightly longer than the left kidney.
1116177
Most cases of polycystic kidney disease have an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the PKD1 or PKD2 gene in each cell. In about 90 percent of these cases, an affected person inherits the mutation from one affected parent.