what is the nf kb pathway?
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What is the NF-κB pathway? NF-κB (nuclear factor kappa light chain enhancer of activated B cells) is a family of highly conserved transcription factors that regulate many important cellular behaviours, in particular, inflammatory responses, cellular growth and apoptosis [1][2].
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Neurofibromatosis type 2 (NF2) is a hereditary condition most commonly associated with bilateral vestibular schwannomas, also known as acoustic neuromas. These are benign (noncancerous) tumors that occur on the nerves for balance and hearing leading to the inner ear.
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Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that are involved in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth, motility, differentiation, and metabolism.
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Protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (i.e. phosphorylation). The enzyme is involved in many biochemical signaling pathways within cells (i.e. signal transduction) and effectors in cellular functions, such as cell proliferation and necrosis.
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The WNT signaling pathway is an evolutionarily conserved signal transduction pathway that regulates a wide range of cellular functions during development and adulthood. ... WNT proteins act as ligands interacting with Frizzled (FZD) receptors on the cell surface to activate intracellular signaling pathways [6,12,13].
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Neurofibromatosis (NF) is a genetic neurological disorder that can affect the brain, spinal cord, nerves and skin. Tumors, or neurofibromas, grow along the body's nerves or on or underneath the skin.
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A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions. ... Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group.
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The classical complement pathway typically requires antigen—antibody complexes (immune complexes) for activation (specific immune response), whereas the alternative pathway can be activated by C3 hydrolysis, foreign material, pathogens, or damaged cells. ... In the alternative pathway, C3b binds to Factor B.
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['KDOQI should always be followed by the (TM) superscript.', 'At the FIRST reference to KDOQI in a document, the guidelines should be referred to as either the National Kidney Foundation or the NKF KDOQI (tm) guidelines. After that they can just be referenced as KDOQI.']
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The pathogenic mechanism of NSAID-induced aseptic meningitis remains unclear. It does not seem to be mediated either by the inhibition of prostaglandin synthesis7 or by the accumulation of ibuprofen's metabolites within the central nervous system (CNS), because the latency period after rechallenge is short.
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A kilobase (kb) is a unit of measurement in molecular biology equal to 1000 base pairs of DNA or RNA.
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Creatine kinase (CK) is also known as creatine phosphokinase (CPK) and is an enzyme that catalyzes the phosphorylation of creatine.
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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.
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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7. 3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP).
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Phosphofructokinase (PFK) is the enzyme that controls the third step of glycolysis, the conversion of fructose-6-phosphate (F6P) into fructose-1,6-biphosphate (F1,6BP). It works by transferring a phosphate group from ATP to F6P. This is the slowest reaction in glycolysis and therefore is the rate-limiting step.
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CREB is a transcription factor that, when activated, binds to cyclic AMP response element (CRE) sequences upstream of open reading frames. CREB is activated by phosphorylation at serine 133 in response to NGF signaling.
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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7. 3.2) expressed by various tissues and cell types.