why is folic acid important with methotrexate?
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Taking folic acid Folic acid helps protect the healthy cells in your body and reduces some of the side effects of methotrexate. It can make you less likely to be sick (vomit) or get diarrhoea. Your doctor will usually start you on one 5mg folic acid tablet, taken once a week. Take it the day after your methotrexate.
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Why should I take folic acid? If you have the right level of folic acid in your body before you get pregnant, it reduces the risk of the baby developing neural tube defects by up to 70%. Neural tube defects are problems with the brain or spinal cord, including spina bifida.
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Vitamin B12 not only helps your body to produce red blood cells, it also helps keep your nervous system healthy. Folate works with vitamin B12 to produce red blood cells, and it is also important for pregnant women, as it helps the baby to grow and develop.
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Folic acid is a B vitamin that helps your body make red blood cells. If you don't have enough red blood cells, you have anemia. Red blood cells carry oxygen to all parts of your body. When you have anemia, your blood can't bring enough oxygen to all your tissues and organs.
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Folic acid acts by helping the body produce and maintain new cells. In particular, red blood cell formation is dependent upon adequate levels of this vitamin. Folic acid deficiency is a known cause of anemia in both adults and children.
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Folic Acid: Folic acid is a B vitamin that can help prevent major birth defects. Take a vitamin with 400 micrograms (mcg) of folic acid every day, before and during pregnancy. Smoking during pregnancy is the single most preventable cause of illness and death among mothers and infants.
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The most commonly recommended dose regimens are 5mg folic acid taken the day after the methotrexate dose or 1mg folic acid daily except on the day of methotrexate. The British Society for Rheumatology recommends that patients on methotrexate are co-prescribed a minimum dose of 5mg folic acid once weekly.
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Folate-deficiency anemia is the lack of folic acid in the blood. Folic acid is a B vitamin that helps your body make red blood cells. If you don't have enough red blood cells, you have anemia. Red blood cells carry oxygen to all parts of your body.
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In folate-deficient megaloblastic anaemia (e.g. because of poor nutrition, pregnancy, or antiepileptic drugs), daily folic acid supplementation for 4 months brings about haematological remission and replenishes body stores.
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Therefore, taking folic acid if you're a woman and not pregnant helps ensure you have adequate levels of folate for a developing fetus before you find out you're pregnant. Additionally, research indicates folic acid may play a preventive role in autism, type 2 diabetes and rheumatoid arthritis.
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Folic acid is indicated for the treatment of megaloblastic anaemia due to folic acid deficiency. It is also used for prophylaxis in chronic haemolytic states, in renal dialysis, and in drug induced folate deficiency. Folic acid is used for the prevention of recurrence of neural tube defects.
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Folic acid and bromelain Other supplements may also help relieve joint pain and reduce your risk of complications from RA treatments. If methotrexate (MTX) is part of your RA treatment, you may need to take a folic acid supplement. Another name for folic acid is vitamin B9.
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Folic Acid: . 8mg/daily, part of a B Vitamin complex. Take with Vitamin B-12. Especially important for people taking Birth Control Pills.
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As a medication, folic acid is used to treat folic acid deficiency and certain types of anemia (lack of red blood cells) caused by folic acid deficiency. Folic acid is sometimes used in combination with other medications to treat pernicious, aplastic, or normocytic anemia.
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Folic acid is the synthetic form of B9, found in supplements and fortified foods, while folate occurs naturally in foods. All the B vitamins are water-soluble, meaning the body does not store them. Folic acid is crucial for proper brain function and plays an important role in mental and emotional health.
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Low‐dose folic acid (equivalent to ≤ 7 mg/week), commonly as a 1 mg daily pill, should be prescribed to rheumatoid arthritis patients taking MTX. A higher persistence to MTX and less switching may also reduce healthcare utilisation and excess medication costs from use of more expensive biologics and other DMARDs.
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Bottom line: always choose supplements with MethylFolate instead of folic acid. Unlike folic acid (FA), MethylFolate, when consumed, does not have to be converted into active folate—being already the body's most active folate form, it can be immediately used by our folate enzyme systems.