drugs are highly protein bound?
603650
A highly protein-bound drug such as aspirin can displace other drugs such as warfarin from their binding sites on plasma proteins; the increase in unbound drug concentration can increase the biological activity of the displaced drug.
117617
Proteins are made up of hundreds or thousands of smaller units called amino acids, which are attached to one another in long chains. There are 20 different types of amino acids that can be combined to make a protein. ... These proteins bind and carry atoms and small molecules within cells and throughout the body.
1043060
Gabapentin does not bind to plasma proteins and is thus distributed in most organs and tissues. Therefore, the mechanism accounting for incontinence could involve not only the brain and the spinal cord but also the local effects of gabapentin on gastrointestinal tract and urinary tract [5].
355900
Uncompetitive inhibition is unique in that the inhibitor binds to the enzyme-substrate complex. This could imply that the binding site for the inhibitor is accessible only after the enzyme has bound to its substrate. As inhibitor binds, the amount of ES complex is reduced.
1432833
Proteins. Proteins, among the most complex of all organic compounds, are composed of amino acids (see Figure 2-4), which contain carbon, hydrogen, oxygen, and nitrogen atoms. Certain amino acids also have sulfur atoms, phosphorus, or other trace elements such as iron or copper.
453873
['Abraxane (chemical name: albumin-bound or nab-paclitaxel)', 'Adriamycin (chemical name: doxorubicin)', 'carboplatin (brand name: Paraplatin)', 'Cytoxan (chemical name: cyclophosphamide)', 'daunorubicin (brand names: Cerubidine, DaunoXome)', 'Doxil (chemical name: doxorubicin)', 'Ellence (chemical name: epirubicin)']
639313
Imidazole is used to elute tagged proteins bound to nickel ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel coordination, freeing the His-tagged proteins.
1375822
By mapping the locations of certain molecules known as histones, scientists can construct a crude map of proteins in the genome. First, however, the proteins and DNA need to be held together in place. ... Disulfide bonds, formed by two sulfur molecules, are common bonds made to achieve this effect.
651734
Proteins are large, complex molecules that play many critical roles in the body. They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs.
924781
fu = fraction of drug unbound in plasma (Cu/C) 1 – fu = fraction of drug bound. 3. fu varies widely among the drugs. Total plasma concentration (C) usually measured rather.
3483
Penicillin has low protein binding in plasma, the bioavailability of penicillin depends on the type; penicillin G has a low bioavailability, below 30%, whereas penicillin V has a higher bioavailability between 60 and 70%. Penicillin has a short half life and is excreted via the kidneys.
1475230
At high pH values, the net charge of most proteins is negative, where they bind to the positively-charged matrix in anion exchangers. When the environment is at a pH value equal to the protein's pI, the net charge is zero, and the protein is not bound to any exchanger, and therefore, can be eluted out.
1414087
Abstract. G-protein-coupled receptors (GPCRs) still offer enormous scope for new therapeutic targets. ... This may be attributable to the heterogeneous nature of GPCRs, their endogenous ligands, and consequently their binding sites.
859901
The proteins regulates the enzymes present in an organism.
1317714
Abraxane (chemical name: albumin-bound or nab-paclitaxel) is a different form of paclitaxel than Taxol (chemical name: paclitaxel). Both medicines are taxanes, a powerful type of chemotherapy medicine that can stop cancer cells from repairing themselves and making new cells.
413475
Both olanzapine and clozapine, drugs with a high risk of weight gain, bind strongly to the histamine H1 and serotonin 5-HT2C receptors. The pharmacology of antipsychotics is not the only factor that determines their effect on weight.
788606
Light chains, also called Bence Jones proteins, make up part of the structure of immunoglobulins. Immunoglobulins are also made up of heavy chains. The light chains attach themselves to the heavy chains and are then called bound light chains.