On one grand boulevard , the Paseo del Prado , are three of Europe 's finest the world-class Prado museum , the Thyssen-Bornemisza collection , and the Centro de Arte Reina Sof ? ­ a ( Queen Sof ? ­ a Art Ceter ) , whose claim to fame is the 20th century 's most famous painting , Pablo Picasso 's Guernica .
All the tourism in the area is centralized to where the Prado museums are .