Our itineraries divide the city 's heart into four from the Duomo north to Piazza San Marco ; from the Piazza della Signoria , its Palazzo Vecchio and the Uffizi Galleries east to Piazza Santa Croce ; from the Mercato Nuovo west to Piazza Santa Maria Novella ; and the southern Left Bank of the Arno River around the Pitti Palace and the Piazzale Michelangelo .
For our itinerary , we suggest seeing all of the city 's heart in one go .