NOECs and LOECs are determined by hypothesis testing ( Dunnett 's Test , a t test with the Bonferroni adjustment , Steel 's Many-One Rank Test , or the Wilcoxon Rank Sum Test with Bonferroni adjustment ) , whereas LCs , ICs , and ECs are determined by point estimation techniques ( Probit Analysis , the Spearman-Karber Method , the Trimmed Spearman-Karber Method , the Graphical Method or Linear Interpolation Method ) .
ICs are also determined through the testing of the hypothesis .