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"&amp;lt;p&amp;gt;&amp;lt;a href=&amp;quot;http://www.ncbi.nlm.nih.gov/pubmed/24454857&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;externalLink&amp;quot; data-ordinal=&amp;quot;1&amp;quot;&amp;gt;Recent research&amp;lt;/a&amp;gt; shores up the theory of &amp;lt;a data-inlink=&amp;quot;-aHvqEAgzXGLiy-a4nGqUw&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/epstein-barr-virus-715661&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;2&amp;quot;&amp;gt;Epstein-Barr virus&amp;lt;/a&amp;gt; (EBV) reactivation as a possible cause of some cases of &amp;lt;a href=&amp;quot;https://www.verywell.com/what-is-chronic-fatigue-syndrome-716113&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;3&amp;quot;&amp;gt;chronic fatigue syndrome&amp;lt;/a&amp;gt; (&amp;lt;a href=&amp;quot;https://www.verywell.com/myalgic-encephalomyelitis-me-715663&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;4&amp;quot;&amp;gt;ME/CFS&amp;lt;/a&amp;gt;.)&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;EBV is in the herpesvirus family. All herpesviruses stay in your system forever, but generally remain dormant most of the time. When they do become active, specialized cells in &amp;lt;a data-inlink=&amp;quot;ya4Db4GswezU8VXrU0hSTA&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/are-fibromyalgia-and-chronic-fatigue-syndrome-the-same-716145&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;5&amp;quot;&amp;gt;the immune system&amp;lt;/a&amp;gt;, including &amp;lt;a data-inlink=&amp;quot;HdOOlERDZnA9sJCZIj6gKQ&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/what-are-b-cells-189441&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;6&amp;quot;&amp;gt;B-cells&amp;lt;/a&amp;gt; and T-cells, typically don&amp;amp;#39;t have a problem knocking them back down again. Most people aren&amp;amp;#39;t even aware that this process is going on. That&amp;amp;#39;s because B- and T-cells, in a healthy immune system, remember the virus and can rapidly assemble an army of antibodies to keep it in check.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;In this study, however, scientists found evidence that the B- and T-cells of many people with ME/CFS were unable to remember EBV, meaning a reactivated virus would be better able to gain a foothold and cause symptoms.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Researchers found this impaired cellular memory in 76% of the 400&amp;amp;#43; study participants. Along with showing what may cause and sustain some cases of ME/CFS, researchers say this work could lead to a long-sought diagnostic marker.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;More About EBV&amp;lt;/strong&amp;gt;&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;EBV is a nasty bug. It&amp;amp;#39;s best known for causing infectious &amp;lt;a data-inlink=&amp;quot;zeBYp-wwXBn815NCgzksng&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/mononucleosis-mono-1191942&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;7&amp;quot;&amp;gt;mononucleosis&amp;lt;/a&amp;gt;, called mono or the &amp;amp;#34;kissing disease.&amp;amp;#34; Symptoms of mono include:&amp;lt;/p&amp;gt;&amp;lt;ul&amp;gt;&amp;lt;li&amp;gt;Fatigue&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Sore throat&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Headache&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Fever&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Muscle aches&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Swollen lymph nodes&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Sensitivity to light&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;Shortness of breath&amp;lt;/li&amp;gt;&amp;lt;/ul&amp;gt;&amp;lt;p&amp;gt;Recovery from &amp;lt;a data-inlink=&amp;quot;kXwDx_DsFyyd4A48YlFFQA&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/how-is-mono-treated-1191950&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;8&amp;quot;&amp;gt;mono&amp;lt;/a&amp;gt; is known to take a long time, and recurrences are marked by &amp;lt;a data-inlink=&amp;quot;MdC-6lEtRtwDxv0MBUGw9w&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/chronic-fatigue-sore-throat-716119&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;9&amp;quot;&amp;gt;extreme fatigue&amp;lt;/a&amp;gt;.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Some researchers have long believed it&amp;amp;#39;s no coincidence that those are also symptoms of ME/CFS, but since a large portion of the population carries EBV and only a small portion develop ME/CFS, it&amp;amp;#39;s been hard to explain (until now) how EBV could contribute to the illness.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Other studies have shown that a significant number of juvenile ME/CFS cases followed mono, and many adolescents whom doctors deem unrecovered from mono fit the ME/CFS diagnostic criteria. It seems that the harder EBV hits, the more likely it is to cause prolonged illness. (Read more about these findings from Cort Johnson at &amp;lt;a href=&amp;quot;http://www.cortjohnson.org/blog/2014/02/21/mono-studies-looking-answers-chronic-fatigue-syndrome/&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;externalLink&amp;quot; data-ordinal=&amp;quot;10&amp;quot; rel=&amp;quot;nofollow&amp;quot;&amp;gt;Health Rising&amp;lt;/a&amp;gt;.)&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;In addition to mono, EBV is linked to certain types of cancer, which could explain the higher incidence of cancer-related illness and death some ME/CFS experts have observed. EBV may also play a role in &amp;lt;a data-inlink=&amp;quot;6ZS1nnxtwEYlNiWDX55JdA&amp;amp;#61;&amp;amp;#61;&amp;quot; href=&amp;quot;https://www.verywell.com/can-i-die-from-multiple-sclerosis-2440637&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;11&amp;quot;&amp;gt;multiple sclerosis&amp;lt;/a&amp;gt;. &amp;lt;a href=&amp;quot;http://www.ncbi.nlm.nih.gov/pubmed/24554817&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;externalLink&amp;quot; data-ordinal=&amp;quot;12&amp;quot;&amp;gt;New research&amp;lt;/a&amp;gt; also suggests it can mimic acute leukemia.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;With this new discovery of impaired cellular memory, we may have filled a significant gap in knowledge about how EBV could be triggering ME/CFS and contributing to on-going symptoms. While more work is needed to verify this study, it could prompt more doctors to prescribe anti-viral medications (such as valacyclovir or valganciclovir) for ME/CFS patients with high EBV titers.&amp;lt;/p&amp;gt;"^^<http://www.w3.org/2001/XMLSchema#string>
<https://www.verywell.com/ebv-reaction-chronic-fatigue-3972945>