We have added a short “outlook-type” paragraph towards the end of the conclusions. In this paragraph we mention three approaches that will facilitate gene discovery, among them large-scale screening techniques as exemplified by the insertion mutant library pointed out by the referee.
There is now available a great resource for the gene discovery in Haloferax volcanii (Kiljunen et al 2014: BMC Biology). A comprehensive insertion mutant library has been generated for this model archaeon in order to facilitate gene discovery. This should be mentitioned and discussed in the text; i.e., how this resource could be used to assign functions for genes.