Can the authors do some analyses using data generated from both primary and metastatic tumors to check if there is any difference of NR2F1 expression, and how NR2F1 expression is correlated with metastasis?
The authors choose chemotherapy as a treatment option to compare it with NR2F1 levels. It would be interesting to see, how NR2F1 levels would change with endocrine treatment and/or endocrine resistance.