Furthermore, controlling their expression may support the improvement of IVF (NOT IFV) outcome.
I requested a major revision including the use of miRNA-resistant exogenous PGRMC1 expression (altered codon usage) to demonstrate that lack of PGRMC1 attenuation will prevent decidualization. That new experimental result is what elevated the required changes to a major revision. The revised manuscript as presently resubmitted is a minor revision. This is a critical point because the very title claims that PGRMC1 downregulation is required for decidualization. This requires stronger evidence than that currently presented. Furthermore, the required experiment is technically not challenging. The authors could consider whether an inducible miRNA-resistant PGRMC1 promoter could be designed. The fact that PGRMC1 levels fall does not mean that low PGRMC1 levels are required. This may be only correlation. Before such a claim is published in the scientific literature, it must be supported by convincing evidence. Aspiration to clarify this in future papers does not merit publication of the present paper.