This might be achieved by using the combination of so-called Tumor Treating fields (TTFields) with targeted drug, I have the following suggestions about this manuscript:
What is the rationale of using 150 kHz TTFields? TTFields at 100 kHz has also shown significant differences as cytotoxicity at p<0.01 and p<0.001 in HepG2 and Huh-7D12 cells which have around 60% and 50% of cell survival. Why did the authors use high frequency of TTFields though the cytotoxicity was also observed in lower dose (Fig 1A).