At the very least this mechanism merits detailed discussion in that section.
2. 15) Line 158/Fig. The western blot (also Fig.3) result must show the entire molecular weight range (e.g. in supplemental data), including MW markers. PGRMC1 is known to be Sumoylated or ubiquitinylated and then degraded by the proteasome pathway, which lead to higher molecular weight species (PMID: 31067491). The latter could well contribute to alterations in PGRMC1 abundance cited by this study. It is important that the involvement of the ubiquitin pathway contribution be either quantified or discarded in well controlled experiments to justify the title of the paper.