We thank the reviewer for pointing out this issue. Quantification of the IHC images was done automatically. The whole slide was scanned, and the CaseViewer software was used to exclude non-tumor areas. The signals of the stained protein and the nuclei were resolved by color deconvolution and quantified separately using the FIJI software (ImageJ) software. Average signal per cell or percent of positive cells was calculated. As the reviewer pointed out, the high magnification images we chose to show do not correctly reflect the quantification performed by the software, and we have now replaced them with better representative fields of the slides.
2) Despite the expression of cleaved PARP was very low in the tumors treated with TTFields or sorafenib alone ( as shown in IHC-images in Figure 4F), the authors declare about ~ 20% of positive cells, as show in the graphs below IHC-staining. Similar, the graphs illustrating the LC3 expression are not in a proper fit with the images shown in Figure 4D.