He reviews some of his previous work and presents an alternative to the dominant ‘Ancient RNA world’ hypothesis.
In Line 114, the role of chromosomal rearrangement in evolution is not well described. What are the effects of genome rearrangements? Several scenarios are possible, including: (1) Genes remain linked R4 probably because it is more efficient to transcribe genes that produce interacting proteins (part of complexes) than those that are not; (2) Genes remain linked if they are of relatively recent origin (rearrangement has not had the change to split them apart); (3) Genes remain linked if they are part of functional groups historically united by genomic regions (encoding metabolic functions or rRNA? ); this includes genes sharing an operon structure for economy purposes in highly reduced organisms such as bacteria; (4) Genes remain linked because they originated when genomic rearrangements were not biochemically motivated and their sequence makeup was later refractory to rearrangement hotspots. There is a rich literature about rearrangement, hotspots and many processes related to these (including domain organization in proteins). Some discussion in this front could be clarifying.