Based on these comments we herewith respond to all questions raised in a point-by-point manner, as follows: Reviewer 1: 1.
Based on the cell line RNA and protein data the expression level of MACC1 is highly variable rather than being present or not. Is there a similar variability present among the tissue samples? Please provide the distribution of the IRS scores of the patient cohort and explain how was IRS 5 chosen as cut off?