Thank you for your valuable advice to prove the significance of PGRMC1 downregulation in decidualization. Salsano et al. (19), reported that overexpression of PGRMC1 in ESCs abrogated the decidual markers expression (page 8. Lines 253-254). We will try to examine the effects of enforced expression of codon-altered PGRMC1 which is resistant for siRNA on decidualization in next study.
Some of the tissue samples are from patients with endometriosis, then according to eutopic endometrium determinism, whether such selection will cause the research results to be inaccurate？ The sample size is small.