R4 Because the EM figures are difficult to view within the Word document, we provide a high-quality figure as a supplement.
In Section 3.5, Analysis of Movement of Filaments, the descriptions were confusing at times. For instance Line 253 states “only in some exceptional cases (the straight line in Figure 6D), net displacement was achieved”. Net displacement presumably refers to any final position after a cycle that differs from the starting position. In other words, net displacement would refer to any value other than zero in Figure 6D. All of the points on this graph appear to indicate net displacement, albeit some less than others. Do the authors mean to state that only in a few instances was a large net displacement achieved? Otherwise the authors’ statement does not appear correct. Perhaps using numerical values instead of statements such as “the average velocity was quite limited” would help to clarify.