We agree that AG-205 is not a specific inhibitor of PGRMC1. Therefore, we examined the effects of siRNA-mediated PGRMC1 knockdown on decidualization. As you mentioned, this issue was not appropriately described in the previously submitted manuscript. The citations have been inserted in the revised manuscript (page 8, lines 258-263).
3) Line 24. AG-205. The authors must refer to the fact that AG-205 is not specific for PGRMC1, contrary to many citations in the literature (such as would be the case here, if uncorrected). Cite PMID: 34944026, PMID: 34680104, PMID: 32924377. Sensitivity of a phenomenon to AG-205 is consistent with possible PGRMC1 involvement, but does not demonstrate PGRMC1 involvement.