The IFITM3 blot shows wide variability with no pattern from one hour to the next, and yet the conclusion is that there is no change in IFITM3 levels during this time period.
Lines 227/228: This sentence is misleading as the references cited are not contradictory, nor are they unclear as to IFITM3 possessing antiviral activity. Furthermore, the authors need to examine the literature more carefully, as previous studies have indeed shown that IFITM3 knockdown in A549 cells increases influenza virus infection, e.g., Lin, Cell Reports, 2013.