Other important autophagy and degradation markers like Beclin1 and P62 need to be shown to reflect the regulatory mechanism of TTFields, as well as for the combined treatment with Sorafenib.
3) It will be much better to provide the data to explain the mechanisms illustrating why the monotherapy of TTFields or sorafenin induced autophagy, whereas the tumors treated with combination developed the substantial apoptotic death of tumor cells.