Thank you for this suggestion. While it would have been interesting to explore this further, our study focuses on retrospectively assessing and comparing disease progression within subgroups of patients receiving TOC. Patients not receiving TOC would have likely had a different presentation, progression and their follow-up would be slightly out of the scope of our observational retrospective study. When we compared patients who received TOC with the 86 severe patients who did not receive TOC (excluded from this analysis), the TOC group was far more severe, so there is no control group that could be matched. In addition, these patients did not have control CT scans.
1 Response to Reviewer 2 Comments Point 1: 2.