Minor Issues: [4] In Figures 3G and 3H, please specify p-values for untreated vs selumetinib in FLO-1/EV and OE33/shMACC1 respectively.
Based on the cell line RNA and protein data the expression level of MACC1 is highly variable rather than being present or not. Is there a similar variability present among the tissue samples? Please provide the distribution of the IRS scores of the patient cohort and explain how was IRS 5 chosen as cut off?