The description has been modified to the following (page 8, lines 261-266). “Although we cannot exclude the possible non-specific action of AG-205 on ESCs, the effect of AG-205 treatment and PGRMC1 knockdown promoted in vitro decidualization. These findings suggested that PGRMC1 downregulation may promote ESC decidualization during the secretory phase.
Lines 263-267: “Because the effect of AG-205 and PGRMC1 knock-down on decidualization was common in the present study, these findings further support for a role for PGRMC1 downregulation in promoting ESC decidualization during the secretory phase.” The reviewer does not understand the sentence.