Our responses to your comments are as follows.
In general, the manuscript refers often to PGRMC1 expression or downregulation. These are fuzzy terms for proteins. It is much preferable to refer to protein abundance, and changes in abundance. Such changes may occur at the translational or post-translational level. Translational level changes can be due to changed levels of transcription, to altered mRNA stability (such as that proposed here for miR-98), or to altered efficiency of translation of a steady state mRNA pool. The authors are strongly advised to change from e.g. ‘expression’ to ‘abundance’ throughout.