In tumors with high Nottingham grade, NR2F1 expression was found to be lower.
This reviewer noticed that all the analysis was performed on the public data sets of bulk RNA-seq or single cell sequencing of primary breast tumors. Can the authors do some analyses using data generated from both primary and metastatic tumors to check if there is any difference of NR2F1 expression, and how NR2F1 expression is correlated with metastasis?