Actually, the comparison was made for cell-based life-like systems. So, I removed 2 references regarding civilization from this part, and add words at line 243 and 276 – 277. And, I simplify descriptions as shown in line 272.
The idea in caption to Fig 4 that building blocks do not interact directly with the environment seems interesting and plausible, but not very well defined. Are you saying a cell interacts with the environment but a single gene does not? Or a multicellular organism interacts but one cell does not? The citations 52 and 53 are in fields that are not related to biology and origin of life. So I think this idea needs to be explained and justified in a biological context.