We thank the reviewer for this comment. The IRS cut-off value 5 reaches a sensitivity of 76.6% and a specificity of 64.2% (Youden Index. We include the arguments into the methods section page 3: To define the cut-off value a ROC curve analysis was performed. 0.408) and was chose as cut-off value (see supplement Figure S1 and Table S1). Additionally, we added the ROC curve and the table with sensitivity, specificity and Youden Index into a supplement section as figure S1 and table S1 Figure S1: ROC Curve for IRS cut-off analysis (AUC 0.716 [0.656 – 0.776]) Positive if Greater than or Equal to Sensitivity 1- Specificity Specificity Youden Index -1 1 1 0 0 1 0,869 0,500 0,500 0,369 3 0,864 0,483 0,517 0,381 5 0,766 0,358 0,642 0,408 7 0,729 0,342 0,658 0,387 8,5 0,421 0,217 0,783 0,204 10,5 0,411 0,200 0,800 0,211 13 0 0 1 0 Table S1: Sensitivity, specificity and Youden Index for different IRS cut-off values.
The authors´answer regarding the cut off is sufficient, please include this argument either in the methods section or as supplementary information.