The sentence referred to was meant to describe only the in vivo outcomes. We have rephrased it to be more accurate and clear: “While each treatment alone elevated levels of autophagy relative to control, TTFields concomitant with sorafenib induced a significant increase versus control in tumor ER stress and apoptosis levels, demonstrating increased stress under the multimodal treatment.” Point 12: Finally, adding to all the above questions, I found a very weak Discussion section which must be extended.
Point 4: Since Annexin V/7-ADD data was not convincing and the authors observed the minor increase of apoptotic cells after HCC cells were treated with combination of TTFields and sorafenib (when compared to the cells treated with TTFields and sorafenib alone), I suggest to run the WBs to examine the expression of the cleaved forms of PARP and caspase-3 (for both HCC cell lines).