demonstrate that PGRMC1 abundance levels are higher in proliferative phase versus secretory phase endometrial patient biopsies (fig.1).
In conclusion, if this published was published in present form then it would invariably be cited as demonstrating that PGRMC1 downregulation by miR-98 causes decidualization. Since that is by no means certain, the study should not be published in its present form. The opportunity should remain open for the authors to convincingly demonstrate the requirement for PGRMC1 down-regulation in decidualization by performing the requested experiments, or others of their devising. However, in the first instance the manuscript cannot be published as it stands, and should therefore be rejected now with the stated option of subsequent resubmission only if new evidence is obtained.