Lastly, with respect to the comment about controlling for physiological noise, the following statements have been added. “Though the evidence is equivocal, it has been suggested that cardiovascular mechanisms may be involved in the hypoalgesic response to exercise [34] and thus statistically controlling for these effects may have influenced the interpretation of our results. However, without controlling physiological differences between EX and QR the neuroimaging data would have been very difficult to interpret.” I don’t see that the reference actually indicates studies of activities of daily living so the authors should revise the sentence or add an appropriate reference.
I will be happy to read the revised version of the manuscript.