Per the reviewer’s request we show below images of the tumors within the liver, which we have also provided now in the supporting material of the paper. As may be seen, the liver itself is much larger than the tumor, and so we did not see value in measuring total liver weight, and hence cannot provide these values. While we tried to reduce variability between the animals by excluding those that at treatment initiation had tumor volumes not within the range 30–100 mm3, there was still divergence between the animals that resulted in the standard deviation bars depicted in the figure. It is however important to mention that there was a very good correlation between tumor volume (as measured by MRI) versus tumor weight at the end of the study, as may be seen in the graph below.
Point 10: Line 337 seems over statement since the data are not shown in the manuscript.