In this section we have tried to describe the classification approach and the rules we have followed to classify the variants. Certainly, we agree with the referee as sometimes the method is mixed with some results. So, we have moved some sentences of the last paragraph of Materials and Methods to Results. “The PM3 evidence (in trans with a pathogenic variant in a recessive disorder) did not con-tribute to the final classification. Not surprisingly (FANCO is an extremely rare FA complementation group) [37], none of the tested variants has been identified in Fanconi Anemia patients (ClinVar and Global Variome shared LOVD databases and literature search-es). Similarly, the BS2 evidence (in trans with a pathogenic variant in a healthy individual) does not contribute to the final classification of our tested variants. Finally, we have considered that some pathogenic (PS2, PM1, PM6, PP2, PP4) and benign (BP1, BP3, BP5) codes are not applicable to the classification of RAD51C variants.” 3-
In the Materials and Methods, the section 2.6 is not actually a section that described some methodology. It appears to be more appropriate as results and maybe some information could be in the introduction.