This manuscript describes a cohort randomized crossover design comparing cutaneous heat pain ratings and brain activity during heat stimuli after conditions of quiet rest and cycling in patients with a physician-confirmed diagnosis of Fibromyalgia (FM) and age and sex matched controls.
However, in the latter case the authors need to address the issue of multiple correlations. Changes in pain sensitivity after exercise versus rest were significantly correlated with changes in activity in DLPFC (exercise vs. rest).