8. This is related to the comments about Fig. I added ref 74, 75. In addition, for the size of ribozyme, I added description at line 565 – 566 and ref 67 – 69.
More fundamentally perhaps, the distinction that is made between CCSI and CMIO is, as the author himself notes, remarkably similar to that between genotype and phenotype, and information and function, and even replication and metabolism. The finding that two RNA molecules would have been sufficient to start life, seems a little like the idea that has been proposed of an RNA template and its complementary copy originally functioning as an informational/functional(= ribozymic) pair (see for example: Shay JA, Huynh C, Higgs PG (2015) J Theor Biol. 364:249-59). Also, as far as this reviewer is aware, there are no known general (= nonspecific) RNA replicase ribozymes consisting of only 100 nucleotides.