We agree with the reviewer that it is the acquisition of multimodality (CT and MRI), with registration of preoperative imaging then intraoperative co-registration. We shared these steps in the “Operative and perioperative management” section (line 60).
This does not detract from the value of the technique, but it is important to clarify that what really is happening is a variety of preoperative imaging is imported and co-registered into the Brain Lab, and then intraoperative MR and occasionally CT data is again obtained and processed and analyzed.