With respect to the reviewer’s comment on generalizability, we agree that our exclusionary criteria were stringent and have added the following sentence to our limitations section. “Further, we excluded individuals with diagnosed mental health conditions and those who were taking medications that could impact pain or the interpretation of brain responses. As such our results may not apply to FM patients with comorbid conditions.”
Following exercise in FM patients, activity was transiently increased in anterior insula and dorsolateral prefrontal cortex (DLPFC) while activity was transienly decreased following rest.