The sentence referred to was meant to describe only the in vivo outcomes. We have rephrased it to be more accurate and clear: “While each treatment alone elevated levels of autophagy relative to control, TTFields concomitant with sorafenib induced a significant increase versus control in tumor ER stress and apoptosis levels, demonstrating increased stress under the multimodal treatment.” Point 12: Finally, adding to all the above questions, I found a very weak Discussion section which must be extended.
GRP78 levels in the groups treated with TTFields or sorafenib alone remained unchanged from the control, but were elevated 2-fold in the TTFields plus sorafenib group (Figure 4f).