To address the reviewer’s concern, we performed statistical analysis of three independent experiments shown in Figure 2B, lower panel. Statistical analysis of mean values of the determined protein amount for IFITM3 shows no statistically significant differences (e.g. p-value of 6 h pi compared to control is 0.5224). We included this information in the figure legend of Figure 2.
Figure 2B: These data need to be improved. The IFITM3 blot shows wide variability with no pattern from one hour to the next, and yet the conclusion is that there is no change in IFITM3 levels during this time period.