The focus of our study is to highlight that successful protection against the whole palette of streptococcal toxins can be achieved by using liposomal nanotraps and to show that the liposome requirements differs between bacterial species and between different types of immune cells. We agree that the SLO neutralization is not novel and simply confirm results from previous publications by us and others. In the current work we do not intend to reveal new neutralization mechanisms either for SLO or for SLS.
It is well-known that SLO binds to the cholesterol-containing lipid bilayer. Therefore, it is obvious that the cholesterol-containing liposomes would neutralise SLO present in the bacterial culture. Therefore, no new information is provided with these experiments.