Thank you for your valuable advice to prove the significance of PGRMC1 downregulation in decidualization. Salsano et al. (19), reported that overexpression of PGRMC1 in ESCs abrogated the decidual markers expression (page 8. Lines 253-254). We will try to examine the effects of enforced expression of codon-altered PGRMC1 which is resistant for siRNA on decidualization in next study.
Author Response Responses to Reviewer 1 We appreciate your review of our manuscript and constructive comments and suggestions.