The description has been modified to the following (page 8, lines 261-266). “Although we cannot exclude the possible non-specific action of AG-205 on ESCs, the effect of AG-205 treatment and PGRMC1 knockdown promoted in vitro decidualization. These findings suggested that PGRMC1 downregulation may promote ESC decidualization during the secretory phase.
The authors have addressed most of my concerns.