There is some concern about the specificity of the AG-205 inhibitor here and throughout, which weakens the deductive reasoning and is discussed below.
14) Lines 153-156, Figure 2. The result must be shown for at least each ESC cell culture (each culture or patient named separately) obtained from each patient to demonstrate that the described results are representative of multiple patients, and not potentially atypical results from an atypical patient. This result must be demonstrated in a substantively convincing manner.