Based on the reviewer´s suggestion, we have now included again the reference showing the infection increase of IAV in A549 IFITM3 knockdown cells and have changed the wording to make the statement clearer. “The mechanism by whichIFITM3 impedes IAV infection was divergent in previous studies and inhibition was mostly described upon IFITM3 over-expression [37, 38, 51]. It was demonstrated that IFITM3 knockdown in A549 cells increases infection rate [37].” Since this paper is primarily studying IFITM localization and clustering at endosomes/lysosomes it should reference studies in which endocytic localization motifs of the IFITMs were identified and characterized (Jia, Cell Microbiol, 2014; Chesarino, JBC, 2015; Li, JBC, 2015)
Figure 4: Uninfected control should be shown in the main text.