Previous studies in colorectal cancer have shown that MACC1 expression (which is associated with poor prognosis) induces cell migration in vitro and metastasis formation in vivo, and these effects can be inhibited by selumetinib.
[4] In Figures 3G and 3H, please specify p-values for untreated vs selumetinib in FLO-1/EV and OE33/shMACC1 respectively. If the difference is statistically significant, please briefly explain/speculate why.