In order to prove that CAF-expressed NR2F1 regulates breast tumor dormancy, one needs to analyze the single-cell sequencing data and show whether the late recurrence in other organs, such as lungs, bones, and brain, other than lymph nodes, is correlated with NR2F1 expression in the CAFs.
We found that NR2F1 is most predominantly expressed in CAFs in the TME of primary breast cancer.