The sentence referred to was meant to describe only the in vivo outcomes. We have rephrased it to be more accurate and clear: “While each treatment alone elevated levels of autophagy relative to control, TTFields concomitant with sorafenib induced a significant increase versus control in tumor ER stress and apoptosis levels, demonstrating increased stress under the multimodal treatment.” Point 12: Finally, adding to all the above questions, I found a very weak Discussion section which must be extended.
The statement “TTFields concomitant with sorafenib induced a significant increase in apoptosis’ in the abstract section is overstated. When compared with sorafenib alone there is practically no difference. Moreover, TTFields failed to increases apoptosis when added to sorafenib and compared to sorafenib alone in one out of two human cells line investigated