The concentration used from selumetinib both for the cell line experiments (10 microM) and for the animal experiments (50 mg/kg) are quite high.
[7] In line 272/273: (i) please report median survival in each group (instead of mean survival), (ii) please specify Hazard ratio with 95% confidence interval (in addition to p values), (iii) please report both overall survival result and disease-specific survival result (since you showed both in Figures).