The authors have addressed most of my concerns.
The salient point concerning the ubiquitination events is that they are correlated for other proteins with proteasome-mediated degradation. Sabbir’s results (ref 31) imply that this also holds for PGRMC1. The new text does not conceptually link PTMs with PGRMC1 protein stability, which is the only reason they should be mentioned. To be clear, protein levels can be mediated by altered rates of transcription, translation, or degradation. This new text should be discussing the possibility of the latter also contributing to the observed effects, as well as the effects of mRNA level that the paper pursues. Lines 300-307.