We appreciate the recommendation and corrected the section as below: Polytopic ligands containing hydrazide-hydrazone moiety (—CO—NHN=CH—) are important for new drug development [1-6]. Because, their polyfunctional nature offer multifarious synthetic ways to derivatize such organic molecules towards suitable and effective drug-receptor interaction. The derivatives of hydrazide-hydrazone moiety specially with heterocyclic system possess a range of biological activities namely, anti-microbial, anti-mycobacterial, antitubercular, anticonvulsant, anticholinesterase [1], antiplatelet, and more importantly antitumor [5,7]. Transition metal complexes derived from such type of ligands have been widely studied since they also demonstrate significant biological and pharmacological properties [8-11].
[8] Zhao, L.; Xu, Z.; Thompson, L. K.; Heath, S. L.; Miller, D. O.; Ohba,.