We thank the reviewer for this excellent suggestion. We have now measured the decay time constants for the NMDA-EPSCs before and after TCN-201. The graph of the data is shown in a new figure in the supplement, Fig. S4. The finding is insightful, and so we have added a paragraph relating to it in the results section, lines 520-536. In answer to the last comment here from the reviewer, the time scale in Fig. 3A is correct – the examples chosen are representative of the group data in terms of the amount of block by TCN-201, but these examples all happen to have faster decays than the examples shown in Figures 1 and 2. In any case, to be more consistent with the formatting in some of the other figures, we have lengthened the scale bar and increased the time proportionally.
Please add a chart about tau changes in Figure 3. Please verify if the time scale is correct in Fig. 3А.