As you pointed out, the possible involvement of posttranslational modification of endometrial PGRMC1 such as sumoylation and ubiquitinylation is interesting. Discussion regarding this possibility has been inserted in the revised manuscript (Page 9, lines 300-307). We will further examine whether posttranslational modification of PGRMC1 could be associated with decidualization in the next study.
In fact, proteasomal degradation could be much more important that miRNA reduction of the transcript in the reduction of PGRMC1 levels during decidualization.