We thanks the reviewer for this comment. We have now elaborated on many issues throughout the discussion, as was described thorough this response letter. Regarding the conclusion, we have rephrased it for better accuracy: “TTFields were identified to be most efficient for treatment of HCC cells at 150 kHz, and this frequency further demonstrated in vivo efficacy.” Why only one frequency was used in vivo, and the difference between frequency and dose, were explained in response 4.
There is a big difference between a therapy which kills vs a therapy which induces a cellular arrest.