Individual mutation of these residues could stabilise PGRMC1 levels to reduce decidualization if miR-98 is only partially responsible for reducing PGRMC1 levels.
Additionally, the methods do not say that all results were repeated at least once, and that a representative results figure is presented. Therefore, the reviewer assumes that experiments have only been performed once. The entire set of experiments needs to be replicated to demonstrate reproducibility before it can be considered to publish these results.