Please discuss how the applied concentrations are related to the clinically used dosage (75 mg administered orally twice https://clinicaltrials.gov/ct2/show/NCT02448290) and why not the more efficient MEK1 inhibitor trametinib was used for the experiments.
[3] Throughout the paper, 10^x wrongly displays as 10x (e.g. "105" instead of "10^5" in lines 152 and 170, "106" instead of "10^6" in line 217, "X2" instead of "X^2" in line 241, "108" instead of "10^8" in lines 353, 354, 365, 366, 367, 368, 370, 371).