Very well presented, clear and graphically illustrated experimental findings that make a clear case for the model.
The authors write: “In these initial stages, the emergence of bistability will serve as a proxy for the emergence of other chemical novelties in the vesicle reactor model.” The authors probably means that the existence of more than one stable regime could consent regime changes, but this situation do not indicates how these changes appear: in the article, the change is stimulated by means of a deliberated injection of chemical substances from outside. So, I think that the appearance of novelties requires a different order of considerations, whereas the bistability plays possibly the role of novelties amplification and consolidation (in particular conditions). The same observation can be done for the word “innovation”, used on the abstract and at Line 45. In order to avoid misunderstandings, I think that the authors should avoid these expressions, ad use the words “regime change”, or similar concepts.