We thank the reviewer for this valuable hint. As suggested, we included p-values in Figure 3G and 3H. In Figure 3G there is a significant increase in migration of cells without MACC1 expression. This is based on a sufficiently large N, that renders even small differences statistically significant. Further, this increase is rather small and is outperformed by the MACC1-mediated increase in migration and the reduction in the MACC1-mediated migration by selumetinib. The data show, that selumetinib does not reduce migration of the MACC1-negative FLO1 and that MACC1 induces migration in this cell line that can be inhibited by selumetinib.
[7] In line 272/273: (i) please report median survival in each group (instead of mean survival), (ii) please specify Hazard ratio with 95% confidence interval (in addition to p values), (iii) please report both overall survival result and disease-specific survival result (since you showed both in Figures).