As you pointed out, the possible involvement of posttranslational modification of endometrial PGRMC1 such as sumoylation and ubiquitinylation is interesting. Discussion regarding this possibility has been inserted in the revised manuscript (Page 9, lines 300-307). We will further examine whether posttranslational modification of PGRMC1 could be associated with decidualization in the next study.
Unfortunately, the authors have been unable to demonstrate the direct involvement of PGRMC1 downregulation in decidualization.