We appreciate the recommendation and updated the molecular docking study by adding more details and literature references as follows, 4.9. Molecular Docking Study Molecular docking is a powerful tool to investigate and provide a proper understanding for ligand receptor interactions in order to facilitate the design of potential drugs [93-96]. To investigate and compare the antimicrobial activity of the synthesized compounds, docking analysis of L1 and L2 against tyrosinase from Bacillus Megaterium were performed. It is well-known that tyrosinase of Bacillus Megaterium bacteria is an attractive target for the development of antimicrobials or antibiotic adjuvants for the treatment of hyperpigmentation because of its similarity (33.5%) to the human enzyme [97-100].
The binding site residues predicted by CASTp for tyrosinase were used for grid generation.