Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
The Description of the Human Body The Description of the Human Body The Description of the Human Body () is an unfinished treatise written in 1647 by René Descartes (1596-1650). Descartes felt knowing oneself was particularly useful. This for him included medical knowledge. He hoped to cure and prevent disease, even to slow down aging. René Descartes believed the soul caused conscious thought. The body caused automatic functions like the beating of the heart and digestion he felt. The body was necessary for voluntary movement as well as the will. However, he believed the power to move the body was wrongly imagined to come from the