Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
How the Lack of Love Affects Two Men a turn when a divorced woman, Oh Mi-mi, rents a room in their house. Both fall in love with her, and they turn on each other to win her heart. "How the Lack of Love Affects Two Men" was released in South Korea on 16 November 2006, and on its opening weekend topped the box office with 179,489 admissions. The film went on to receive a total of 593,277 admissions nationwide, with a gross (as of 26 November 2006) of $2,470,615. How the Lack of Love Affects Two Men How the Lack of Love Affects Two Men () is a