Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
Sound Affects Sound Affects Sound Affects is the fifth studio album by British rock band the Jam. The cover art is a pastiche of the artwork used on various "Sound Effects" records produced by the BBC during the 1970s. It is their only album co-produced by the band, and contains the only album track co-written by the entire band, "Music for the Last Couple". The album was released on 28 November 1980. Paul Weller is known to have opined "Sound Affects" as the best album The Jam released throughout their career; freely admitting the Beatles' "Revolver" had been a major influence upon