Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
How the Lack of Love Affects Two Men How the Lack of Love Affects Two Men How the Lack of Love Affects Two Men () is a 2006 South Korean film. Dong Chol-dong is a widower who lives with his only son, Dong-hyun. Chol-dong makes his living by blackmailing companies for their immoral activities, and in his spare time devotes himself to such activities as measuring the length of toilet paper, so he can sue the paper company if it is shorter than advertised. His son, Dong-hyun, is a bully who will go to any lengths to get what he wants. The lives of these two men take