Ichthyosis vulgaris is converted to filaggrin which plays a vital role in the structure of the skin). Around 10% of the population have some detrimental mutations to the profilaggrin gene that is also linked to atopic dermatitis (another skin disorder that is often present with ichthyosis vulgaris). The exact mutation is only known for some cases of ichthyosis vulgaris. It is generally considered to be an autosomal dominant condition, i.e., a single genetic mutation causes the disease and an affected person has a 50% chance of passing the condition on to their child. There is some research indicating it may be semi-dominant.
The Body Silent The Body Silent The Body Silent is a personal narrative written by Robert Murphy, a professor at Columbia University. This piece is a narrative of personal struggle through a spinal condition, published in 1987 by Henry Holt and Company, Inc. He uses this narrative to tell his journey through a deteriorating spinal condition leading to paraplegia. He was diagnosed with a tumor extending from his second cervical vertebra to the eighth thoracic vertebra in 1972. Through his narrative he tells his medical history and how the diagnosis of old medicine (late 1920s) knew very little about neurology, and left undetected