Ichthyosis vulgaris is converted to filaggrin which plays a vital role in the structure of the skin). Around 10% of the population have some detrimental mutations to the profilaggrin gene that is also linked to atopic dermatitis (another skin disorder that is often present with ichthyosis vulgaris). The exact mutation is only known for some cases of ichthyosis vulgaris. It is generally considered to be an autosomal dominant condition, i.e., a single genetic mutation causes the disease and an affected person has a 50% chance of passing the condition on to their child. There is some research indicating it may be semi-dominant.
Sound Affects Sound Affects Sound Affects is the fifth studio album by British rock band the Jam. The cover art is a pastiche of the artwork used on various "Sound Effects" records produced by the BBC during the 1970s. It is their only album co-produced by the band, and contains the only album track co-written by the entire band, "Music for the Last Couple". The album was released on 28 November 1980. Paul Weller is known to have opined "Sound Affects" as the best album The Jam released throughout their career; freely admitting the Beatles' "Revolver" had been a major influence upon