Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
The Bringers of Wonder, Part One Koenig, Helena gives as good as she gets. Across the room, Vincent is showing Louisa one of the remote medical relays which allow them to monitor patients from anywhere on the base. He observes Koenig's obvious distress, but Louisa stares into his eyes and he, in a trance-like state, switches off the monitor. When the girl is swept away by Carter, Vincent's head clears. Reactivating the screen, he observes Koenig's condition and dashes from the room. Koenig is convulsing by the time Vincent reaches Medical. He throws the orderly away from the brain complex, but the man attacks him with