Effects of tightlacing on the body Others believed that every time the bladder or rectum emptied, the uterus was unable to be lifted back into place due to weak ligaments, causing head and back pain, and inability to stand or walk, and improper menstruation. However, this line of thought rested on very little evidence and the assumption that the uterus was one of the most important organs in a woman's body, and it is unlikely that the uterus actually suffered from corsetry. Victorian doctors believed there was a relationship between gallstones and tightlacing, the corset causing extreme weight loss. (Gallstones are the result of the body
Adult polyglucosan body disease Adult polyglucosan body disease Adult polyglucosan body disease (APBD) is an orphan disease and a glycogen storage disorder that is caused by an inborn error of metabolism. Symptoms can emerge any time after the age of 30; early symptoms include trouble controlling urination, trouble walking, and lack of sensation in the legs. People eventually develop dementia. A person inherits loss-of-function mutations in the "GBE1" gene from each parent, and the lack of glycogen branching enzyme (the protein encoded by "GNE1") leads to buildup of unbranched glycogen in cells, which harms neurons more than other kinds of cells. Most people first