Harlequin-type ichthyosis condition are extremely sensitive to changes in temperature due to their hard cracked skin, which prevents normal heat loss. Respiration is also restricted by the skin, which impedes the chest wall from expanding and drawing in enough air. This can lead to hypoventilation and respiratory failure. Patients are often dehydrated, as their plated skin is not well suited to retaining water. The diagnosis of harlequin-type ichthyosis relies on both physical examination and certain laboratory tests. Physical assessment at birth is vital for the initial diagnosis of harlequin ichthyosis. Physical examination reveals characteristic symptoms of the condition especially the abnormalities in
The Bringers of Wonder, Part One Koenig, Helena gives as good as she gets. Across the room, Vincent is showing Louisa one of the remote medical relays which allow them to monitor patients from anywhere on the base. He observes Koenig's obvious distress, but Louisa stares into his eyes and he, in a trance-like state, switches off the monitor. When the girl is swept away by Carter, Vincent's head clears. Reactivating the screen, he observes Koenig's condition and dashes from the room. Koenig is convulsing by the time Vincent reaches Medical. He throws the orderly away from the brain complex, but the man attacks him with