Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
Which Medical Device Which Medical Device Which Medical Device is a review site for medical devices with reviews, medical device news and videos of medical procedures. Users can rate and review medical devices listed on the website, or suggest devices for inclusion and review. The website also publishes device reviews from an editorial team and encourages users to submit detailed reviews. Device manufacturers pay a fee to submit expanded product information to the website. Which Medical Device was launched in September 2010 by Dr Philip Haslam (an Interventional Radiologist based at the Freeman Hospital, Newcastle upon Tyne, United Kingdom) alongside colleague Mr Craig