Harlequin-type ichthyosis condition are extremely sensitive to changes in temperature due to their hard cracked skin, which prevents normal heat loss. Respiration is also restricted by the skin, which impedes the chest wall from expanding and drawing in enough air. This can lead to hypoventilation and respiratory failure. Patients are often dehydrated, as their plated skin is not well suited to retaining water. The diagnosis of harlequin-type ichthyosis relies on both physical examination and certain laboratory tests. Physical assessment at birth is vital for the initial diagnosis of harlequin ichthyosis. Physical examination reveals characteristic symptoms of the condition especially the abnormalities in
Association for Improving the Condition of the Poor A. Kingsbury, later on the Commission of Public Charities (1914–1917) and Harry L. Hopkins the future director of President Franklin D. Roosevelt's Works Progress Administration, part of the New Deal. Notes Association for Improving the Condition of the Poor The Association for Improving the Condition of the Poor (AICP) was a charitable organization in New York City, established in 1843 and incorporated in 1848 with the aim of helping the deserving poor and providing for their moral uplift. The Association was one of the most active and innovative charity organizations in New York, pioneering many private-public partnerships in education, healthcare