Geneva Around this time, the House of Savoy came to at least nominally dominate the city. In the 15th century, an oligarchic republican government emerged with the creation of the Grand Council. In the first half of the 16th century, the Protestant Reformation reached the city, causing religious strife, during which Savoy rule was thrown off and Geneva allied itself with the Swiss Confederacy. In 1541, with Protestantism on the rise, John Calvin, the founder of Calvinism, became the spiritual leader of the city and established the Republic of Geneva. By the 18th century, Geneva had come under the influence of
Geneva such as Caterpillar, DuPont, and Cargill have their international headquarters in the city; Take Two Interactive, Electronic Arts, INVISTA, Procter & Gamble and Oracle Corporation have their European headquarters in the city. Hewlett Packard has its Europe, Africa, and Middle East headquarters in Meyrin, near Geneva, as does PrivatAir. There is a long tradition of watchmaking in the city, which dates back to the 16th century. Many watchmakers have been based in Geneva since their foundation, such as (Baume et Mercier, Charriol, Chopard, Franck Muller, Patek Philippe, Rolex, Universal Genève, Raymond Weil, Vacheron Constantin and Frédérique Constant). Two major international