Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
Catholic theology of the body virginity, the Christian sacrament of marriage, and derived issues such as faithfulness and contraception. Official Church teaching on the subject was stated in the encyclical "Deus caritas est" ("On Christian Love") from Pope Benedict XVI, promulgated on Christmas, December 25, 2005. Some early Church fathers, like Origen were preoccupied with the body and its impediments. The theology of early Church fathers focused on the body in terms of its origin, condition before the fall of man, and destination and relation to the soul. Questions were raised as to whether the body may impede the soul in its attempt to be