On the Origin of Species the manuscript for his "big book" on Species, "Natural Selection". By mid March 1859 Darwin's abstract had reached the stage where he was thinking of early publication; Lyell suggested the publisher John Murray, and met with him to find if he would be willing to publish. On 28 March Darwin wrote to Lyell asking about progress, and offering to give Murray assurances "that my Book is not more "un"-orthodox, than the subject makes inevitable." He enclosed a draft title sheet proposing "An abstract of an Essay on the Origin of Species and Varieties Through natural selection", with the year shown
Genetics and the Origin of Species variation would allow populations to evolve rapidly as environmental conditions change. This book was a landmark in the evolutionary synthesis, as it presented the union of Mendelian genetics and Darwinian theory. In "Genetics and the Origin of Species", polyploidy is considered as a type of mutation. Polyploid cells have a chromosome number that is more than twice the haploid number. The effects of polyploidy between two different species causes hybridization and even greater evolution. Natural selection in an environment produces reproductive success, which benefits the species. Speciation is a process of evolution through which new biological species are formed. Dobzhansky