Human eye layer, known as the fibrous tunic, is composed of the cornea and sclera. The middle layer, known as the vascular tunic or uvea, consists of the choroid, ciliary body, pigmented epithelium and iris. The innermost is the retina, which gets its oxygenation from the blood vessels of the choroid (posteriorly) as well as the retinal vessels (anteriorly). The spaces of the eye are filled with the aqueous humour anteriorly, between the cornea and lens, and the vitreous body, a jelly-like substance, behind the lens, filling the entire posterior cavity. The aqueous humour is a clear watery fluid that is contained
DecisionDx-UM of the eye which includes the iris, ciliary body, and choroid. Treatment for the primary eye tumor consists of eye-sparing therapy (plaque radiotherapy or proton beam irradiation) or eye removal (enucleation). Both are highly effective with ‘cure’ rates above 90%. However, as has been well documented in multiple publications including the Collaborative Ocular Melanoma Study (COMS), in nearly 50% of patients the melanoma has likely already metastasized by the time the primary eye tumor has been diagnosed and treated. The majority of these metastases are microscopic and clinically undetectable at the time of primary tumor diagnosis. Unfortunately, many of the