Harlequin-type ichthyosis Harlequin-type ichthyosis Harlequin-type ichthyosis is a genetic disorder which results in thickened skin over nearly the entire body at birth. The skin forms large, diamond-shaped plates that are separated by deep cracks. They affect the shape of the eyelids, nose, mouth, and ears, and limit movement of the arms and legs. Restricted movement of the chest can lead to breathing difficulties. These plates fall off over several weeks. Other complications can include premature birth, infection, problems with body temperature, and dehydration. Harlequin-type ichthyosis is due to mutations of the "ABCA12" genes. It is inherited from a person's parents in an
The Human Condition (Magritte) The Human Condition (Magritte) The Human Condition (La condition humaine) generally refers to two similar oil on canvas paintings by the Belgian surrealist René Magritte. One was completed in 1933 and is in the collection of the National Gallery of Art in Washington DC. The other was completed in 1935 and is part of the Simon Spierer Collection in Geneva, Switzerland. A number of drawings of the same name exist as well, including one at the Cleveland Museum of Art. One of Magritte's most common artistic devices was the use of objects to hide what lies behind them. For example,