Ichthyosis vulgaris is converted to filaggrin which plays a vital role in the structure of the skin). Around 10% of the population have some detrimental mutations to the profilaggrin gene that is also linked to atopic dermatitis (another skin disorder that is often present with ichthyosis vulgaris). The exact mutation is only known for some cases of ichthyosis vulgaris. It is generally considered to be an autosomal dominant condition, i.e., a single genetic mutation causes the disease and an affected person has a 50% chance of passing the condition on to their child. There is some research indicating it may be semi-dominant.
Henneke horse body condition scoring system strenuous work and also may lack lean muscle. Horses with a very high body condition score carry too much weight, which interferes with stamina and biomechanics. Some studies addressed the relationship of body condition score and endurance performance in endurance races. In a study of the 1990 Purina Race of Champions (a 241-km / 150-mile, 2-day endurance race), it was found that the top-7 finishers of the race (i.e. highly competitive horses) had significantly lower body condition scores and marginally less rump fat than horses eliminated for metabolic criteria (i.e. less competitive horses). By contrast, two studies on the Tevis