Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
The Human Condition (Magritte) The Human Condition (Magritte) The Human Condition (La condition humaine) generally refers to two similar oil on canvas paintings by the Belgian surrealist René Magritte. One was completed in 1933 and is in the collection of the National Gallery of Art in Washington DC. The other was completed in 1935 and is part of the Simon Spierer Collection in Geneva, Switzerland. A number of drawings of the same name exist as well, including one at the Cleveland Museum of Art. One of Magritte's most common artistic devices was the use of objects to hide what lies behind them. For example,