Effects of tightlacing on the body Others believed that every time the bladder or rectum emptied, the uterus was unable to be lifted back into place due to weak ligaments, causing head and back pain, and inability to stand or walk, and improper menstruation. However, this line of thought rested on very little evidence and the assumption that the uterus was one of the most important organs in a woman's body, and it is unlikely that the uterus actually suffered from corsetry. Victorian doctors believed there was a relationship between gallstones and tightlacing, the corset causing extreme weight loss. (Gallstones are the result of the body
Adult polyglucosan body disease People with adult polyglucosan body disease typically first experience signs and symptoms related to the condition between ages 30 and 60. APBD is an autosomal recessive disorder that is caused when a person inherits genes from both parents containing one or more loss-of-function mutations in the gene "GBE1" which encodes for glycogen branching enzyme, also called 1,4-alpha-glucan-branching enzyme. The "GBE1" gene provides instructions for making the glycogen branching enzyme. This enzyme is involved in the production of a complex sugar called glycogen, which is a major source of stored energy in the body. Most "GBE1" gene mutations result in a