Diktyoma mitotic activity, sarcomatous components, or invasion into the uvea, cornea, or sclera. Most diktyomas are malignant. The most common symptoms of diktyoma are vision loss and pain, while the most common signs are leukocoria and presence of a mass in the iris or ciliary body. Other signs and symptoms include lens subluxation, glaucoma, cataract, exophthalmos, buphthalmos, strabismus, and ptosis. Imaging studies such as ultrasonography (US), Computerized Tomography (CT) and Magnetic Resonance Imaging (MRI) may aid diagnosis. On ultrasound, diktyomas typically appear as echogenic, irregularly shaped to ovoid masses. Ultrasound is excellent for demonstrating cystic collections of vitreous fluid in the
DecisionDx-UM of the eye which includes the iris, ciliary body, and choroid. Treatment for the primary eye tumor consists of eye-sparing therapy (plaque radiotherapy or proton beam irradiation) or eye removal (enucleation). Both are highly effective with ‘cure’ rates above 90%. However, as has been well documented in multiple publications including the Collaborative Ocular Melanoma Study (COMS), in nearly 50% of patients the melanoma has likely already metastasized by the time the primary eye tumor has been diagnosed and treated. The majority of these metastases are microscopic and clinically undetectable at the time of primary tumor diagnosis. Unfortunately, many of the