Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
Association for Improving the Condition of the Poor A. Kingsbury, later on the Commission of Public Charities (1914–1917) and Harry L. Hopkins the future director of President Franklin D. Roosevelt's Works Progress Administration, part of the New Deal. Notes Association for Improving the Condition of the Poor The Association for Improving the Condition of the Poor (AICP) was a charitable organization in New York City, established in 1843 and incorporated in 1848 with the aim of helping the deserving poor and providing for their moral uplift. The Association was one of the most active and innovative charity organizations in New York, pioneering many private-public partnerships in education, healthcare