On the Origin of Species the manuscript for his "big book" on Species, "Natural Selection". By mid March 1859 Darwin's abstract had reached the stage where he was thinking of early publication; Lyell suggested the publisher John Murray, and met with him to find if he would be willing to publish. On 28 March Darwin wrote to Lyell asking about progress, and offering to give Murray assurances "that my Book is not more "un"-orthodox, than the subject makes inevitable." He enclosed a draft title sheet proposing "An abstract of an Essay on the Origin of Species and Varieties Through natural selection", with the year shown
On the Origin of Species species, immigration of others and, where suitable variations occurred, descendants of some species became adapted to new conditions. He remarks that the artificial selection practised by animal breeders frequently produced sharp divergence in character between breeds, and suggests that natural selection might do the same, saying: But how, it may be asked, can any analogous principle apply in nature? I believe it can and does apply most efficiently, from the simple circumstance that the more diversified the descendants from any one species become in structure, constitution, and habits, by so much will they be better enabled to seize on many