Harlequin-type ichthyosis condition are extremely sensitive to changes in temperature due to their hard cracked skin, which prevents normal heat loss. Respiration is also restricted by the skin, which impedes the chest wall from expanding and drawing in enough air. This can lead to hypoventilation and respiratory failure. Patients are often dehydrated, as their plated skin is not well suited to retaining water. The diagnosis of harlequin-type ichthyosis relies on both physical examination and certain laboratory tests. Physical assessment at birth is vital for the initial diagnosis of harlequin ichthyosis. Physical examination reveals characteristic symptoms of the condition especially the abnormalities in
Sound Affects Sound Affects Sound Affects is the fifth studio album by British rock band the Jam. The cover art is a pastiche of the artwork used on various "Sound Effects" records produced by the BBC during the 1970s. It is their only album co-produced by the band, and contains the only album track co-written by the entire band, "Music for the Last Couple". The album was released on 28 November 1980. Paul Weller is known to have opined "Sound Affects" as the best album The Jam released throughout their career; freely admitting the Beatles' "Revolver" had been a major influence upon