Ichthyosis with confetti Ichthyosis with confetti Ichthyosis en confetti, also known as ichthyosis with confetti, congenital reticular ichthyosiform erythroderma (CRIE) and ichthyosis variegata, is a very rare form of congenital ichthyosis in which healthy patches of normal skin co-exist within the abnormal skin areas. The condition is caused by a frameshift mutation in the keratin 10 gene (KRT10); mutant keratin 10 accumulates in the nucleolus, a sub-nuclear structure, rather than within cellular intermedite filaments like the wild-type protein. Children with the condition exhibit red, flaky skin; however, for reasons not yet totally clear, wild type clonal patches of skin start to appear, in
Supernumerary body part sometimes represented as having numerous breasts. This was particularly notable in the cult of Artemis (Diana) celebrated in the ancient city of Ephesus, in modern Turkey. In Japanese mythology, the god of the sea and storms, Susanoo, is sometimes depicted as having a third arm. In Hungarian mythology, having six fingers on a hand (polydactyly) is held to be the sign of innate supernatural power (see táltos). In the Bible, Goliath has brothers who have six fingers and six toes. Supernumerary body part Supernumerary body parts are most commonly a congenital disorder involving the growth of an additional part of