Nusrit Shaheen Nusrit Shaheen Nusrit "Nelly" Shaheen (born 1984) is the longest-living survivor of harlequin-type ichthyosis in the United Kingdom and one of the longest-living in the world. She lives in Coventry, and was one of nine children. Four of her siblings had harlequin, but died at a young age. Many survivors of harlequin are predicted to die before or during their teens, but Nelly is now in her 30s and contributing to living a long, healthy and rewarding life. Nelly's medical condition, harlequin-type ichthyosis, is a seriously rare genetic condition which means her skin forms up to 10x more than the
Estrogen-dependent condition Estrogen-dependent condition An estrogen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of estrogenic activity in the body. Known estrogen-dependent conditions include mastodynia (breast pain/tenderness), breast fibroids, mammoplasia (breast enlargement), macromastia (breast hypertrophy), gynecomastia, breast cancer, precocious puberty in girls, melasma, menorrhagia, endometriosis, endometrial hyperplasia, adenomyosis, uterine fibroids, uterine cancers (e.g., endometrial cancer), ovarian cancer, and hyperestrogenism in males such as in certain conditions like cirrhosis and Klinefelter's syndrome. Such conditions may be treated with drugs with antiestrogen actions, including selective estrogen receptor modulators (SERMs)