Nusrit Shaheen Nusrit Shaheen Nusrit "Nelly" Shaheen (born 1984) is the longest-living survivor of harlequin-type ichthyosis in the United Kingdom and one of the longest-living in the world. She lives in Coventry, and was one of nine children. Four of her siblings had harlequin, but died at a young age. Many survivors of harlequin are predicted to die before or during their teens, but Nelly is now in her 30s and contributing to living a long, healthy and rewarding life. Nelly's medical condition, harlequin-type ichthyosis, is a seriously rare genetic condition which means her skin forms up to 10x more than the
Estrogen-dependent condition such as tamoxifen and clomifene, estrogen receptor antagonists such as fulvestrant, aromatase inhibitors such as anastrozole and exemestane, gonadotropin-releasing hormone (GnRH) analogues such as leuprorelin and cetrorelix, and/or other antigonadotropins such as danazol, gestrinone, megestrol acetate, and medroxyprogesterone acetate. Estrogen-dependent condition An estrogen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of estrogenic activity in the body. Known estrogen-dependent conditions include mastodynia (breast pain/tenderness), breast fibroids, mammoplasia (breast enlargement), macromastia (breast hypertrophy), gynecomastia, breast cancer, precocious puberty in girls, melasma, menorrhagia, endometriosis, endometrial hyperplasia, adenomyosis,