Generate text that refutes this claim: Animal research necessitates significant harm to the animals involved  Animal research, by its very nature necessitates harm to the animals. Even if they are not made to suffer as part of the experiment, the vast majority of animals used, must be killed at the conclusion of the experiment. With 115 million animals being used in the status quo this is no small issue. Even if we were to vastly reduce animal experimentation, releasing domesticated animals into the wild, would be a death sentence, and it hardly seems realistic to think that many behaviourally abnormal animals, often mice or rats, might be readily moveable into the pet trade. [1] It is prima fasciae obvious, that it is not in the interest of the animals involved to be killed, or harmed to such an extent that such killing might seem merciful. Even if the opposition counterargument, that animals lack the capacity to truly suffer, is believed, research should none the less be banned in order to prevent the death of millions of animals.  [1] European Commission, 1997. Euthanasia of experimental animals. Luxembourg: Office for official publications
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Firstly, due to our larger and more sophisticated brains, one would expect the average human to have a great many more interests than any animal, for those interests to be more complex and interconnected, and for there to be a greater capacity for reflection and comprehension of the satisfaction gleaned from the realisation of such interests. Thus, we can ascribe greater value to the life of a human than an animal, and thus conclude there to be less harm in painlessly killing an animal than a human. Secondly, to the extent that research on animals is of benefit to humans, it is thus permissible to conduct experiments requiring euthanasia of the animal subjects. [1]  [1] Frey, R. G., “Moral Standing: The Value of Life and Specieism”, in La Follette (ed.), Ethics in Practice, (Malden, Mass; Oxford : Blackwell Pub, 2007)