CREATE TABLE medicine_enzyme_interaction (enzyme_id DECIMAL, medicine_id DECIMAL, interaction_type TEXT)
CREATE TABLE enzyme (id DECIMAL, name TEXT, location TEXT, product TEXT, chromosome TEXT, omim DECIMAL, porphyria TEXT)
CREATE TABLE medicine (id DECIMAL, name TEXT, trade_name TEXT, fda_approved TEXT)

Show the medicine names and trade names that cannot interact with the enzyme with product 'Heme'.
SELECT name, trade_name FROM medicine EXCEPT SELECT T1.name, T1.trade_name FROM medicine AS T1 JOIN medicine_enzyme_interaction AS T2 ON T2.medicine_id = T1.id JOIN enzyme AS T3 ON T3.id = T2.enzyme_id WHERE T3.product = 'Protoporphyrinogen IX'
SELECT "name", "trade_name" FROM "medicine" EXCEPT SELECT "T1"."name", "T1"."trade_name" FROM "medicine" AS "T1" JOIN "medicine_enzyme_interaction" AS "T2" ON "T1"."id" = "T2"."medicine_id" JOIN "enzyme" AS "T3" ON "T2"."enzyme_id" = "T3"."id" AND "T3"."product" = 'Protoporphyrinogen IX'