CREATE TABLE table_22224 ("Enzyme" TEXT, "Location" TEXT, "Substrate" TEXT, "Product" TEXT, "Chromosome" TEXT, "EC" TEXT, "OMIM" FLOAT, "Porphyria" TEXT)

give the location of subtrate coproporphyrinogen iii
SELECT "Location" FROM table_22224 WHERE "Substrate" = 'Coproporphyrinogen III'
SELECT "Location" FROM "table_22224" WHERE "Substrate" = 'Coproporphyrinogen III'