CREATE TABLE medicine (id DECIMAL, name TEXT, trade_name TEXT, fda_approved TEXT)
CREATE TABLE medicine_enzyme_interaction (enzyme_id DECIMAL, medicine_id DECIMAL, interaction_type TEXT)
CREATE TABLE enzyme (id DECIMAL, name TEXT, location TEXT, product TEXT, chromosome TEXT, omim DECIMAL, porphyria TEXT)

What are the medicine and trade names that cannot interact with the enzyme with the product 'Heme'?
SELECT name, trade_name FROM medicine EXCEPT SELECT T1.name, T1.trade_name FROM medicine AS T1 JOIN medicine_enzyme_interaction AS T2 ON T2.medicine_id = T1.id JOIN enzyme AS T3 ON T3.id = T2.enzyme_id WHERE T3.product = 'Protoporphyrinogen IX'
SELECT "name", "trade_name" FROM "medicine" EXCEPT SELECT "T1"."name", "T1"."trade_name" FROM "medicine" AS "T1" JOIN "medicine_enzyme_interaction" AS "T2" ON "T1"."id" = "T2"."medicine_id" JOIN "enzyme" AS "T3" ON "T2"."enzyme_id" = "T3"."id" AND "T3"."product" = 'Protoporphyrinogen IX'