CREATE TABLE table_53850 ("Species" TEXT, "Strain" TEXT, "Type" TEXT, "Base Pairs" FLOAT, "Genes" FLOAT)

How many genes have a Species of leptospira interrogans, and a Base Pairs smaller than 4,277,185?
SELECT SUM("Genes") FROM table_53850 WHERE "Species" = 'leptospira interrogans' AND "Base Pairs" < '4,277,185'
SELECT SUM("Genes") FROM "table_53850" WHERE "Base Pairs" < '4,277,185' AND "Species" = 'leptospira interrogans'