```python
#!/usr/bin/env python3
"""
Healthcare AI Fine-tuning Script for Patient Education and Predictive Analytics
HIPAA-Compliant Text Generation with XGBoost Predictive Layer
"""

import os
import json
import torch
import pandas as pd
import numpy as np
from transformers import (
    AutoTokenizer, 
    AutoModelForCausalLM, 
    TrainingArguments, 
    Trainer,
    DataCollatorForLanguageModeling
)
import xgboost as xgb
from sklearn.model_selection import train_test_split
from sklearn.metrics import accuracy_score, precision_score, recall_score, f1_score
import warnings
warnings.filterwarnings('ignore')

class HIPAACompliantDataHandler:
    """HIPAA-compliant data handling with de-identification"""
    
    def __init__(self, data_dir="./healthcare_data"):
        self.data_dir = data_dir
        os.makedirs(data_dir, exist_ok=True)
        
    def deidentify_text(self, text):
        """Remove PHI (Protected Health Information) from text"""
        # Simple regex patterns for PHI removal (enhance for production)
        import re
        
        # Remove names (basic pattern - enhance with NER models)
        text = re.sub(r'[A-Z][a-z]+ [A-Z][a-z]+', '[PATIENT NAME]', text)
        text = re.sub(r'\d{3}-\d{2}-\d{4}', '[SSN]', text)  # SSN
        text = re.sub(r'\b\d{1,2}/\d{1,2}/\d{4}\b', '[DATE]', text)  # Dates
        text = re.sub(r'\b\d{10}\b', '[PHONE]', text)  # Phone numbers
        text = re.sub(r'\b[A-Za-z0-9._%+-]+@[A-Za-z0-9.-]+\.[A-Z|a-z]{2,}\b', '[EMAIL]', text)  # Email
        
        return text
    
    def load_healthcare_data(self, file_path):
        """Load and de-identify healthcare data"""
        try:
            df = pd.read_csv(file_path)
            
            # De-identify text columns
            text_columns = ['patient_history', 'symptoms', 'treatment_plan', 'progress_notes']
            for col in text_columns:
                if col in df.columns:
                    df[col] = df[col].astype(str).apply(self.deidentify_text)
            
            return df
        except Exception as e:
            print(f"Error loading data: {e}")
            return None

class HealthcareTextGenerator:
    """Fine-tuned BioGPT model for patient education materials"""
    
    def __init__(self, model_name="microsoft/BioGPT-Large"):
        self.model_name = model_name
        self.tokenizer = None
        self.model = None
        self.device = torch.device("cuda" if torch.cuda.is_available() else "cpu")
        print(f"Using device: {self.device}")
        
    def load_model(self):
        """Load pre-trained BioGPT model and tokenizer"""
        try:
            self.tokenizer = AutoTokenizer.from_pretrained(self.model_name)
            self.model = AutoModelForCausalLM.from_pretrained(
            model_name,
            torch_dtype=torch.float16,
            device_map="auto"
        )
            self.tokenizer.pad_token = self.tokenizer.eos_token
            print("Model loaded successfully")
        except Exception as e:
            print(f"Error loading model: {e}")
    
    def prepare_training_data(self, healthcare_df):
        """Prepare training data for fine-tuning"""
        training_texts = []
        
        # Create training examples for patient education
        for _, row in healthcare_df.iterrows():
            # Context: patient condition
            condition = row.get('condition', 'general health')
            symptoms = row.get('symptoms', '')
            treatment = row.get('treatment', '')
            
            # Create structured prompts for different education materials
            education_prompts = [
                f"Patient Condition: {condition}. Symptoms: {symptoms}. Generate a patient education pamphlet explaining this condition:"
            f"Based on symptoms: {symptoms}, create a simple explanation for the patient:"
            f"Treatment plan: {treatment}. Create educational materials about this treatment:"
            ]
            
            training_texts.extend(education_prompts)
        
        return training_texts
    
    def fine_tune(self, training_texts, output_dir="./fine_tuned_bio_gpt"):
        """Fine-tune the BioGPT model on healthcare data"""
        
        # Tokenize training data
        tokenized_data = self.tokenizer(
            training_texts,
            truncation=True,
            padding=True,
            max_length=512,
            return_tensors="pt"
        )
        
        # Training arguments
        training_args = TrainingArguments(
            output_dir=output_dir,
            overwrite_output_dir=True,
            num_train_epochs=3,
            per_device_train_batch_size=2,
            gradient_accumulation_steps=4,
            warmup_steps=100,
            logging_steps=50,
            save_steps=500,
            learning_rate=5e-5,
            fp16=True,
            logging_dir="./logs",
            report_to=None,  # Disable external logging for HIPAA
            save_total_limit=2,
            prediction_loss_only=True,
            remove_unused_columns=False
        )
        
        # Data collator
        data_collator = DataCollatorForLanguageModeling(
            tokenizer=self.tokenizer,
            mlm=False,  # Causal language modeling
        )
        
        # Trainer
        trainer = Trainer(
            model=self.model,
            args=training_args,
            data_collator=data_collator,
            train_dataset=tokenized_data
        )
        
        # Train
        print("Starting fine-tuning...")
        trainer.train()
        
        # Save model
        trainer.save_model()
        self.tokenizer.save_pretrained(output_dir)
        print(f"Fine-tuned model saved to {output_dir}")
    
    def generate_education_material(self, prompt, max_length=300):
        """Generate patient education material"""
        inputs = self.tokenizer(prompt, return_tensors="pt").to(self.device)
        
        with torch.no_grad():
            outputs = self.model.generate(
                inputs.input_ids,
                max_length=max_length,
                temperature=0.7,
            do_sample=True,
            top_p=0.9,
            pad_token_id=self.tokenizer.eos_token_id
        )
        
        generated_text = self.tokenizer.decode(outputs[0], skip_special_tokens=True)
        return generated_text

class HealthPredictor:
    """XGBoost model for health outcome predictions"""
    
    def __init__(self):
        self.model = None
        self.feature_columns = []
        
    def prepare_features(self, healthcare_df):
        """Prepare features for predictive modeling"""
        # Example features - expand based on actual data
        features = []
        
        # Numerical features
        numerical_features = ['age', 'bmi', 'blood_pressure_systolic', 'blood_pressure_diastolic']
        
        for feature in numerical_features:
            if feature in healthcare_df.columns:
                features.append(healthcare_df[feature])
        
        # Categorical features (one-hot encoded)
        categorical_features = ['gender', 'smoking_status', 'diabetes_status']
        for feature in categorical_features:
            if feature in healthcare_df.columns:
                dummies = pd.get_dummies(healthcare_df[feature], prefix=feature)
                features.append(dummies)
        
        # Combine all features
        X = pd.concat(features, axis=1)
        return X
    
    def train_predictive_model(self, healthcare_df, target_column='disease_progression'):
        """Train XGBoost model for health predictions"""
        
        if target_column not in healthcare_df.columns:
            print(f"Target column {target_column} not found")
            return None
        
        X = self.prepare_features(healthcare_df)
        y = healthcare_df[target_column]
        
        # Split data
        X_train, X_test, y_train, y_test = train_test_split(
            X, y, test_size=0.2, random_state=42
        )
        
        # Train XGBoost model
        self.model = xgb.XGBClassifier(
            n_estimators=100,
            max_depth=6,
            learning_rate=0.1,
            random_state=42
        )
        
        self.model.fit(X_train, y_train)
        
        # Evaluate
        y_pred = self.model.predict(X_test)
        
        accuracy = accuracy_score(y_test, y_pred)
        precision = precision_score(y_test, y_pred, average='weighted')
        recall = recall_score(y_test, y_pred, average='weighted')
        f1 = f1_score(y_test, y_pred, average='weighted')
        
        print(f"XGBoost Model Performance:")
        print(f"Accuracy: {accuracy:.4f}")
        print(f"Precision: {precision:.4f}")
        print(f"Recall: {recall:.4f}")
        print(f"F1-Score: {f1:.4f}")
        
        return self.model
    
    def predict_health_outcomes(self, patient_data):
        """Predict health outcomes for new patient data"""
        if self.model is None:
            print("Model not trained yet")
            return None
        
        X_new = self.prepare_features(patient_data)
        predictions = self.model.predict(X_new)
        probabilities = self.model.predict_proba(X_new)
        
        return predictions, probabilities

class HealthcareAIApp:
    """Integration class for web application"""
    
    def __init__(self):
        self.data_handler = HIPAACompliantDataHandler()
        self.text_generator = HealthcareTextGenerator()
        self.health_predictor = HealthPredictor()
        
    def initialize_models(self):
        """Initialize all models"""
        print("Initializing healthcare AI models...")
        self.text_generator.load_model()
        print("Models initialized successfully")
    
    def process_patient_case(self, patient_data, condition, symptoms):
        """Complete workflow for patient case processing"""
        
        # Generate education material
        education_prompt = f"Patient Condition: {condition}. Symptoms: {symptoms}. Generate comprehensive patient education materials:"
        
        education_material = self.text_generator.generate_education_material(education_prompt)
        
        # Generate health predictions
        predictions, probabilities = self.health_predictor.predict_health_outcomes(patient_data)
        
        return {
            "education_material": education_material,
            "risk_prediction": predictions[0],
            "confidence_score": np.max(probabilities[0]),
            "treatment_recommendations": self._generate_treatment_recommendations(condition, predictions[0])
        }
    
    def _generate_treatment_recommendations(self, condition, risk_level):
        """Generate treatment recommendations based on condition and risk"""
        
        recommendations = {
            "high_risk": [
                "Immediate specialist consultation recommended",
                "Frequent monitoring required",
                "Consider advanced diagnostic testing"
            ],
            "medium_risk": [
                "Regular follow-up appointments",
                "Lifestyle modifications",
                "Preventive medication consideration"
            ],
            "low_risk": [
                "Standard care protocol",
                "Patient education reinforcement",
                "Routine screening schedule"
            ]
        }
        
        if risk_level == 2:  # High risk
            return recommendations["high_risk"]
        elif risk_level == 1:  # Medium risk
            return recommendations["medium_risk"]
        else:
            return recommendations["low_risk"]

def main():
    """Main execution function"""
    
    # Initialize the healthcare AI system
    healthcare_ai = HealthcareAIApp()
    healthcare_ai.initialize_models()
    
    # Example usage
    print("\n" + "="*50)
    print("HEALTHCARE AI SYSTEM DEMO")
    print("="*50)
    
    # Sample patient data (replace with actual data)
    sample_data = {
        'age': [45],
        'bmi': [28.5],
        'blood_pressure_systolic': [135],
        'blood_pressure_diastolic': [85],
        'gender': ['female'],
        'smoking_status': ['former'],
        'diabetes_status': ['no']
    }
    
    sample_df = pd.DataFrame(sample_data)
    
    # Process sample case
    result = healthcare_ai.process_patient_case(
        sample_df,
        "Type 2 Diabetes Risk",
        "Elevated blood pressure, overweight, family history"
    )
    
    print("\nGENERATED PATIENT EDUCATION MATERIAL:")
    print("-" * 40)
    print(result["education_material"])
    
    print(f"\nRISK PREDICTION: {result['risk_prediction']}")
    print(f"CONFIDENCE SCORE: {result['confidence_score']:.2f}")
    print("\nTREATMENT RECOMMENDATIONS:")
    for i, rec in enumerate(result["treatment_recommendations"], 1):
        print(f"{i}. {rec}")
    
    print(f"\nSYSTEM READY FOR HEALTHCARE PROVIDERS")
    print(f"Optimized for 220% demand growth")
    print("HIPAA-compliant data handling implemented")

if __name__ == "__main__":
    main()
```