di-zhang-fdu/orderly_qa_new · Datasets at Hugging Face

problem stringlengths 128 864	answer stringlengths 1 43
Using COC(=O)C(C)(C)N, O=C(Cl)CCl to produce COC(=O)C(C)(C)NC(=O)CCl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, O
Using COC(=O)C(C)(C)N, O=C(Cl)CCl to produce COC(=O)C(C)(C)NC(=O)CCl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, O
Using Oc1ccc(OCc2ccccc2)cc1, Brc1cncnc1 to produce Oc1ccc(Oc2cncnc2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O, O
Using Oc1ccc(OCc2ccccc2)cc1, Brc1cncnc1 to produce Oc1ccc(Oc2cncnc2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O, O
Using CCC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)ccn1, Fc1ccc(-c2nn3c(c2I)CCCC3)cc1 to produce CCC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nn3c2CCCC3)ccn1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1COCCO1, CCOC(C)=O
Using CCC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)ccn1, Fc1ccc(-c2nn3c(c2I)CCCC3)cc1 to produce CCC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nn3c2CCCC3)ccn1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1COCCO1, CCOC(C)=O
Using CC1CCCC(C)C1Oc1ccc2c(n1)OCCN(C(=O)OC(C)(C)C)C2 to produce CC1CCCC(C)C1Oc1ccc2c(n1)OCCNC2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O
Using CC1CCCC(C)C1Oc1ccc2c(n1)OCCN(C(=O)OC(C)(C)C)C2 to produce CC1CCCC(C)C1Oc1ccc2c(n1)OCCNC2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O
Using CCC(CC)(CO)CS(N)(=O)=O, Clc1ccc2nccn2n1 to produce CCC(CC)(COc1ccc2nccn2n1)CS(N)(=O)=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O
Using CCC(CC)(CO)CS(N)(=O)=O, Clc1ccc2nccn2n1 to produce CCC(CC)(COc1ccc2nccn2n1)CS(N)(=O)=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O
Using CCOC(CBr)OCC, Cc1ccccc1S to produce CCOC(CSc1ccccc1C)OCC, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using CCOC(CBr)OCC, Cc1ccccc1S to produce CCOC(CSc1ccccc1C)OCC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using NCCN1CCOCC1, CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O to produce NCCn1c(=O)c(C(=O)NCCN2CCOCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO, O
Using NCCN1CCOCC1, CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O to produce NCCn1c(=O)c(C(=O)NCCN2CCOCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO, O
Using CC(C)C(Cl)C=C(Cl)C(F)(F)F to produce CC(C)=CC=C(Cl)C(F)(F)F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O, O
Using CC(C)C(Cl)C=C(Cl)C(F)(F)F to produce CC(C)=CC=C(Cl)C(F)(F)F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O, O
Using CCOC(=O)c1c(OS(=O)(=O)C(F)(F)F)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, CNC to produce CCOC(=O)c1c(N(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, C1CCOC1
Using CCOC(=O)c1c(OS(=O)(=O)C(F)(F)F)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, CNC to produce CCOC(=O)c1c(N(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, C1CCOC1
Using CCOC(=O)c1cc[nH]n1, COc1ccc(C(=O)CBr)cc1OC to produce CCOC(=O)c1ccnn1CC(=O)c1ccc(OC)c(OC)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CC(C)=O
Using CCOC(=O)c1cc[nH]n1, COc1ccc(C(=O)CBr)cc1OC to produce CCOC(=O)c1ccnn1CC(=O)c1ccc(OC)c(OC)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CC(C)=O
Using CC(=O)CC(C)=O, CCN(CC)Cc1cccc(N)c1 to produce CCN(CC)Cc1cccc(NC(C)=CC(C)=O)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CC(=O)O, Cc1ccccc1
Using CC(=O)CC(C)=O, CCN(CC)Cc1cccc(N)c1 to produce CCN(CC)Cc1cccc(NC(C)=CC(C)=O)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CC(=O)O, Cc1ccccc1
Using COC(=O)C=Cc1ccc2c(c1)cc(C)n2C(=O)OC(C)(C)C to produce CC(C)(C)OC(=O)n1ccc2cc(C=CCO)ccc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using COC(=O)C=Cc1ccc2c(c1)cc(C)n2C(=O)OC(C)(C)C to produce CC(C)(C)OC(=O)n1ccc2cc(C=CCO)ccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CC(C)(N=NC(C)(C)C(=O)[O-])C(=O)[O-], CC(C)CN to produce CC(C)CNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCC(C)C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, CO
Using CC(C)(N=NC(C)(C)C(=O)[O-])C(=O)[O-], CC(C)CN to produce CC(C)CNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCC(C)C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, CO
Using Cc1ncc(C(=NOCc2cccc(N3C(=O)c4ccccc4C3=O)n2)c2ccccc2)n1C to produce Cc1ncc(C(=NOCc2cccc(N)n2)c2ccccc2)n1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, C1CCOC1
Using Cc1ncc(C(=NOCc2cccc(N3C(=O)c4ccccc4C3=O)n2)c2ccccc2)n1C to produce Cc1ncc(C(=NOCc2cccc(N)n2)c2ccccc2)n1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, C1CCOC1
Using COC(CNC(=O)OCc1ccccc1)OC to produce O=CCNC(=O)OCc1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, C1CCOC1
Using COC(CNC(=O)OCc1ccccc1)OC to produce O=CCNC(=O)OCc1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, C1CCOC1
Using O=C(Nc1cc(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc(S(=O)(=O)O)c12)c1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc([N+](=O)[O-])c1 to produce Nc1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O
Using O=C(Nc1cc(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc(S(=O)(=O)O)c12)c1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc([N+](=O)[O-])c1 to produce Nc1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O
Using Oc1ccc(I)cc1, NC(=O)c1ccc(Cl)nc1 to produce NC(=O)c1ccc(Oc2ccc(I)cc2)nc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, CC(=O)N(C)C
Using Oc1ccc(I)cc1, NC(=O)c1ccc(Cl)nc1 to produce NC(=O)c1ccc(Oc2ccc(I)cc2)nc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, CC(=O)N(C)C
Using C[C@@H](OCc1ccccc1)[C@@H](COCC(=O)c1cc(F)c(F)c(F)c1)NC(=O)OC(C)(C)C to produce C[C@@H](O)[C@H]1COC[C@@H](c2cc(F)c(F)c(F)c2)N1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O
Using C[C@@H](OCc1ccccc1)[C@@H](COCC(=O)c1cc(F)c(F)c(F)c1)NC(=O)OC(C)(C)C to produce C[C@@H](O)[C@H]1COC[C@@H](c2cc(F)c(F)c(F)c2)N1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O
Using CCNCC1CCN(Cc2ccccc2)C1 to produce CCNCC1CCNC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using CCNCC1CCN(Cc2ccccc2)C1 to produce CCNCC1CCNC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using O=S(=O)(OCC(F)(F)F)C(F)(F)F, COc1cnnc(-c2ccnn2-c2ccccc2)c1O to produce COc1cn(CC(F)(F)F)nc(-c2ccnn2-c2ccccc2)c1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O, CO
Using O=S(=O)(OCC(F)(F)F)C(F)(F)F, COc1cnnc(-c2ccnn2-c2ccccc2)c1O to produce COc1cn(CC(F)(F)F)nc(-c2ccnn2-c2ccccc2)c1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CN(C)C=O, CO
Using CN(C)C=O, CC(C)(C)[Si](OC[C@@H]1C[C@H]1COS(C)(=O)=O)(c1ccccc1)c1ccccc1 to produce CC(C)(C)[Si](OC[C@@H]1C[C@H]1CC#N)(c1ccccc1)c1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O
Using CN(C)C=O, CC(C)(C)[Si](OC[C@@H]1C[C@H]1COS(C)(=O)=O)(c1ccccc1)c1ccccc1 to produce CC(C)(C)[Si](OC[C@@H]1C[C@H]1CC#N)(c1ccccc1)c1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O
Using COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=Cc2cccnc2)cc1-c1ccccc1 to produce COC(=O)[C@H](CCSC)NC(=O)c1ccc(CCc2cccnc2)cc1-c1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=Cc2cccnc2)cc1-c1ccccc1 to produce COC(=O)[C@H](CCSC)NC(=O)c1ccc(CCc2cccnc2)cc1-c1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using CCN(CC1CCCC1)c1nc2c(cc1C#N)CCCC2 to produce CCN(CC1CCCC1)c1nc2c(cc1CN)CCCC2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CCN(CC1CCCC1)c1nc2c(cc1C#N)CCCC2 to produce CCN(CC1CCCC1)c1nc2c(cc1CN)CCCC2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using Cc1c([N+](=O)[O-])cnn1C to produce Cc1c(N)cnn1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using Cc1c([N+](=O)[O-])cnn1C to produce Cc1c(N)cnn1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using Cc1ccc2[nH]cc(CCN)c2c1, O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1 to produce Cc1ccc2[nH]cc(CCNc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])c2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, CCO
Using Cc1ccc2[nH]cc(CCN)c2c1, O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1 to produce Cc1ccc2[nH]cc(CCNc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])c2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	O, CCO
Using CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(I)c1, C#C[Si](C)(C)C to produce CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(C#C[Si](C)(C)C)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCN(CC)CC, C1CCOC1
Using CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(I)c1, C#C[Si](C)(C)C to produce CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(C#C[Si](C)(C)C)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCN(CC)CC, C1CCOC1
Using Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CC2)c(C)c1 to produce Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C)C)CC2)c(C)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CC2)c(C)c1 to produce Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C)C)CC2)c(C)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CC(C)(C)OC(=O)c1sc([N+](=O)[O-])c(S(N)(=O)=O)c1CNS(C)(=O)=O to produce CS(=O)(=O)NCc1csc([N+](=O)[O-])c1S(N)(=O)=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1COCCO1
Using CC(C)(C)OC(=O)c1sc([N+](=O)[O-])c(S(N)(=O)=O)c1CNS(C)(=O)=O to produce CS(=O)(=O)NCc1csc([N+](=O)[O-])c1S(N)(=O)=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1COCCO1
Using O=C([O-])O, N#Cc1ncc(F)cc1F to produce O=Cc1ncc(F)cc1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClCCl
Using O=C([O-])O, N#Cc1ncc(F)cc1F to produce O=Cc1ncc(F)cc1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClCCl
Using O=C(c1ccccc1)c1ccc(O)cc1O, Cc1oc(-c2ccccc2)nc1CCl to produce Cc1oc(-c2ccccc2)nc1COc1ccc(C(=O)c2ccccc2)c(O)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CC(C)=O
Using O=C(c1ccccc1)c1ccc(O)cc1O, Cc1oc(-c2ccccc2)nc1CCl to produce Cc1oc(-c2ccccc2)nc1COc1ccc(C(=O)c2ccccc2)c(O)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CC(C)=O
Using CC(C)(C)OC(=O)Nc1cc(Cl)cc(Oc2cncnc2)c1 to produce Nc1cc(Cl)cc(Oc2cncnc2)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1COCCO1
Using CC(C)(C)OC(=O)Nc1cc(Cl)cc(Oc2cncnc2)c1 to produce Nc1cc(Cl)cc(Oc2cncnc2)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1COCCO1
Using O=[N+]([O-])c1c(Cl)nc(C2CC2)nc1Cl to produce Nc1c(Cl)nc(C2CC2)nc1Cl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using O=[N+]([O-])c1c(Cl)nc(C2CC2)nc1Cl to produce Nc1c(Cl)nc(C2CC2)nc1Cl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c(F)cccc1-2, II to produce CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c-2ccc(I)c1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c(F)cccc1-2, II to produce CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c-2ccc(I)c1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CNC(=O)c1ccc(F)c2c(C(=O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12 to produce CNC(=O)c1ccc(F)c2c(C(O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using CNC(=O)c1ccc(F)c2c(C(=O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12 to produce CNC(=O)c1ccc(F)c2c(C(O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using [O-]c1ccccc1, CC(C)(C)C(=O)OC1Cn2c(-c3ccnc(S(C)(=O)=O)n3)c(-c3ccc(F)cc3)c(=O)n2C1 to produce O=c1c(-c2ccc(F)cc2)c(-c2ccnc(Oc3ccccc3)n2)n2n1CC(O)C2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using [O-]c1ccccc1, CC(C)(C)C(=O)OC1Cn2c(-c3ccnc(S(C)(=O)=O)n3)c(-c3ccc(F)cc3)c(=O)n2C1 to produce O=c1c(-c2ccc(F)cc2)c(-c2ccnc(Oc3ccccc3)n2)n2n1CC(O)C2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using COC(=O)c1cc(-c2ccc(F)cc2)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1 to produce CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc(F)cc3)cc2C(=O)O)cs1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1, CO
Using COC(=O)c1cc(-c2ccc(F)cc2)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1 to produce CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc(F)cc3)cc2C(=O)O)cs1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1, CO
Using CN, NC(=O)c1cc(-c2ccc(C=O)s2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12 to produce CNCc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CCCN5CCOCC5)CC4)c3c2)s1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClCCl, CO
Using CN, NC(=O)c1cc(-c2ccc(C=O)s2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12 to produce CNCc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CCCN5CCOCC5)CC4)c3c2)s1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClCCl, CO
Using CC(C)(C)OC(=O)n1cnc2ccc(F)cc21, CCOC(=O)c1ccc(Oc2nccnc2Cl)cc1 to produce O=C(c1ccc(Oc2nccnc2Cl)cc1)c1nc2ccc(F)cc2[nH]1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CC(C)(C)OC(=O)n1cnc2ccc(F)cc21, CCOC(=O)c1ccc(Oc2nccnc2Cl)cc1 to produce O=C(c1ccc(Oc2nccnc2Cl)cc1)c1nc2ccc(F)cc2[nH]1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using N=C(N)N, CCOC(=O)CC(=O)C(OCC)OCC to produce CCOC(OCC)c1cc(=O)[nH]c(N)n1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using N=C(N)N, CCOC(=O)CC(=O)C(OCC)OCC to produce CCOC(OCC)c1cc(=O)[nH]c(N)n1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO
Using CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O, N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21 to produce CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClCCl
Using CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O, N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21 to produce CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClCCl
Using CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(O)cc3C)c2)cc1F, OC1CCSCC1 to produce CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(OC4CCSCC4)cc3C)c2)cc1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(O)cc3C)c2)cc1F, OC1CCSCC1 to produce CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(OC4CCSCC4)cc3C)c2)cc1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	C1CCOC1
Using N#Cc1cccc(C2OC(O)c3cnccc32)c1 to produce N#Cc1cccc(C(O)c2ccncc2CO)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, CCO
Using N#Cc1cccc(C2OC(O)c3cnccc32)c1 to produce N#Cc1cccc(C(O)c2ccncc2CO)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, CCO
Using [OH-], CCCCCCCC1CCC(=O)O1 to produce CCCCCCCC(O)CCC(=O)[O-], please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using [OH-], CCCCCCCC1CCC(=O)O1 to produce CCCCCCCC(O)CCC(=O)[O-], please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using Cc1ccc(Cl)c(Oc2cc(C#N)cc(Cl)n2)c1F, O=C1CCC(=O)N1Br to produce N#Cc1cc(Cl)nc(Oc2c(Cl)ccc(CBr)c2F)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClC(Cl)(Cl)Cl
Using Cc1ccc(Cl)c(Oc2cc(C#N)cc(Cl)n2)c1F, O=C1CCC(=O)N1Br to produce N#Cc1cc(Cl)nc(Oc2c(Cl)ccc(CBr)c2F)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	ClC(Cl)(Cl)Cl
Using [NH2-], COc1ccc2ccncc2c1 to produce Nc1nccc2ccc(O)cc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, Cc1ccccc1C
Using [NH2-], COc1ccc2ccncc2c1 to produce Nc1nccc2ccc(O)cc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, Cc1ccccc1C
Using COC(=O)COc1cc(N)nc(C)c1C#N to produce COC(=O)COc1cc(N)nc(C)c1CN, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO, CO
Using COC(=O)COc1cc(N)nc(C)c1C#N to produce COC(=O)COc1cc(N)nc(C)c1CN, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO, CO
Using O=C(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1 to produce OC(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO, O
Using O=C(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1 to produce OC(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCO, O
Using C#Cc1ccccc1, Nc1cc(Br)ccc1[N+](=O)[O-] to produce Nc1cc(C#Cc2ccccc2)ccc1[N+](=O)[O-], please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, CC(C)NC(C)C
Using C#Cc1ccccc1, Nc1cc(Br)ccc1[N+](=O)[O-] to produce Nc1cc(C#Cc2ccccc2)ccc1[N+](=O)[O-], please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, CC(C)NC(C)C
Using CN(C)C=O, CCOC(=O)c1cc(OC)c2ccn(C3CC3)c2c1 to produce CCOC(=O)c1cc(OC)c2c(C=O)cn(C3CC3)c2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, O=P(Cl)(Cl)Cl
Using CN(C)C=O, CCOC(=O)c1cc(OC)c2ccn(C3CC3)c2c1 to produce CCOC(=O)c1cc(OC)c2c(C=O)cn(C3CC3)c2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CCOC(C)=O, O=P(Cl)(Cl)Cl
Using CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc([N+](=O)[O-])c(N)c3)c2)CC1 to produce CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(N)c(N)c3)c2)CC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO
Using CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc([N+](=O)[O-])c(N)c3)c2)CC1 to produce CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(N)c(N)c3)c2)CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.	CO

Using COC(=O)C(C)(C)N, O=C(Cl)CCl to produce COC(=O)C(C)(C)NC(=O)CCl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, O

Using COC(=O)C(C)(C)N, O=C(Cl)CCl to produce COC(=O)C(C)(C)NC(=O)CCl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, O

Using Oc1ccc(OCc2ccccc2)cc1, Brc1cncnc1 to produce Oc1ccc(Oc2cncnc2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O, O

Using Oc1ccc(OCc2ccccc2)cc1, Brc1cncnc1 to produce Oc1ccc(Oc2cncnc2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O, O

Using CCC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)ccn1, Fc1ccc(-c2nn3c(c2I)CCCC3)cc1 to produce CCC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nn3c2CCCC3)ccn1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1COCCO1, CCOC(C)=O

Using CCC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)ccn1, Fc1ccc(-c2nn3c(c2I)CCCC3)cc1 to produce CCC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nn3c2CCCC3)ccn1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1COCCO1, CCOC(C)=O

Using CC1CCCC(C)C1Oc1ccc2c(n1)OCCN(C(=O)OC(C)(C)C)C2 to produce CC1CCCC(C)C1Oc1ccc2c(n1)OCCNC2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O

Using CC1CCCC(C)C1Oc1ccc2c(n1)OCCN(C(=O)OC(C)(C)C)C2 to produce CC1CCCC(C)C1Oc1ccc2c(n1)OCCNC2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O

Using CCC(CC)(CO)CS(N)(=O)=O, Clc1ccc2nccn2n1 to produce CCC(CC)(COc1ccc2nccn2n1)CS(N)(=O)=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O

Using CCC(CC)(CO)CS(N)(=O)=O, Clc1ccc2nccn2n1 to produce CCC(CC)(COc1ccc2nccn2n1)CS(N)(=O)=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O

Using CCOC(CBr)OCC, Cc1ccccc1S to produce CCOC(CSc1ccccc1C)OCC, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using CCOC(CBr)OCC, Cc1ccccc1S to produce CCOC(CSc1ccccc1C)OCC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using NCCN1CCOCC1, CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O to produce NCCn1c(=O)c(C(=O)NCCN2CCOCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO, O

Using NCCN1CCOCC1, CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O to produce NCCn1c(=O)c(C(=O)NCCN2CCOCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO, O

Using CC(C)C(Cl)C=C(Cl)C(F)(F)F to produce CC(C)=CC=C(Cl)C(F)(F)F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O, O

Using CC(C)C(Cl)C=C(Cl)C(F)(F)F to produce CC(C)=CC=C(Cl)C(F)(F)F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O, O

Using CCOC(=O)c1c(OS(=O)(=O)C(F)(F)F)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, CNC to produce CCOC(=O)c1c(N(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, C1CCOC1

Using CCOC(=O)c1c(OS(=O)(=O)C(F)(F)F)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, CNC to produce CCOC(=O)c1c(N(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, C1CCOC1

Using CCOC(=O)c1cc[nH]n1, COc1ccc(C(=O)CBr)cc1OC to produce CCOC(=O)c1ccnn1CC(=O)c1ccc(OC)c(OC)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CC(C)=O

Using CCOC(=O)c1cc[nH]n1, COc1ccc(C(=O)CBr)cc1OC to produce CCOC(=O)c1ccnn1CC(=O)c1ccc(OC)c(OC)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CC(C)=O

Using CC(=O)CC(C)=O, CCN(CC)Cc1cccc(N)c1 to produce CCN(CC)Cc1cccc(NC(C)=CC(C)=O)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CC(=O)O, Cc1ccccc1

Using CC(=O)CC(C)=O, CCN(CC)Cc1cccc(N)c1 to produce CCN(CC)Cc1cccc(NC(C)=CC(C)=O)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CC(=O)O, Cc1ccccc1

Using COC(=O)C=Cc1ccc2c(c1)cc(C)n2C(=O)OC(C)(C)C to produce CC(C)(C)OC(=O)n1ccc2cc(C=CCO)ccc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using COC(=O)C=Cc1ccc2c(c1)cc(C)n2C(=O)OC(C)(C)C to produce CC(C)(C)OC(=O)n1ccc2cc(C=CCO)ccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CC(C)(N=NC(C)(C)C(=O)[O-])C(=O)[O-], CC(C)CN to produce CC(C)CNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCC(C)C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, CO

Using CC(C)(N=NC(C)(C)C(=O)[O-])C(=O)[O-], CC(C)CN to produce CC(C)CNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCC(C)C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, CO

Using Cc1ncc(C(=NOCc2cccc(N3C(=O)c4ccccc4C3=O)n2)c2ccccc2)n1C to produce Cc1ncc(C(=NOCc2cccc(N)n2)c2ccccc2)n1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, C1CCOC1

Using Cc1ncc(C(=NOCc2cccc(N3C(=O)c4ccccc4C3=O)n2)c2ccccc2)n1C to produce Cc1ncc(C(=NOCc2cccc(N)n2)c2ccccc2)n1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, C1CCOC1

Using COC(CNC(=O)OCc1ccccc1)OC to produce O=CCNC(=O)OCc1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, C1CCOC1

Using COC(CNC(=O)OCc1ccccc1)OC to produce O=CCNC(=O)OCc1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, C1CCOC1

Using O=C(Nc1cc(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc(S(=O)(=O)O)c12)c1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc([N+](=O)[O-])c1 to produce Nc1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O

Using O=C(Nc1cc(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc(S(=O)(=O)O)c12)c1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc([N+](=O)[O-])c1 to produce Nc1cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc(C(=O)Nc2cc(S(=O)(=O)O)cc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O

Using Oc1ccc(I)cc1, NC(=O)c1ccc(Cl)nc1 to produce NC(=O)c1ccc(Oc2ccc(I)cc2)nc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, CC(=O)N(C)C

Using Oc1ccc(I)cc1, NC(=O)c1ccc(Cl)nc1 to produce NC(=O)c1ccc(Oc2ccc(I)cc2)nc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, CC(=O)N(C)C

Using C[C@@H](OCc1ccccc1)[C@@H](COCC(=O)c1cc(F)c(F)c(F)c1)NC(=O)OC(C)(C)C to produce C[C@@H](O)[C@H]1COC[C@@H](c2cc(F)c(F)c(F)c2)N1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O

Using C[C@@H](OCc1ccccc1)[C@@H](COCC(=O)c1cc(F)c(F)c(F)c1)NC(=O)OC(C)(C)C to produce C[C@@H](O)[C@H]1COC[C@@H](c2cc(F)c(F)c(F)c2)N1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O

Using CCNCC1CCN(Cc2ccccc2)C1 to produce CCNCC1CCNC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using CCNCC1CCN(Cc2ccccc2)C1 to produce CCNCC1CCNC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using O=S(=O)(OCC(F)(F)F)C(F)(F)F, COc1cnnc(-c2ccnn2-c2ccccc2)c1O to produce COc1cn(CC(F)(F)F)nc(-c2ccnn2-c2ccccc2)c1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O, CO

Using O=S(=O)(OCC(F)(F)F)C(F)(F)F, COc1cnnc(-c2ccnn2-c2ccccc2)c1O to produce COc1cn(CC(F)(F)F)nc(-c2ccnn2-c2ccccc2)c1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CN(C)C=O, CO

Using CN(C)C=O, CC(C)(C)[Si](OC[C@@H]1C[C@H]1COS(C)(=O)=O)(c1ccccc1)c1ccccc1 to produce CC(C)(C)[Si](OC[C@@H]1C[C@H]1CC#N)(c1ccccc1)c1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O

Using CN(C)C=O, CC(C)(C)[Si](OC[C@@H]1C[C@H]1COS(C)(=O)=O)(c1ccccc1)c1ccccc1 to produce CC(C)(C)[Si](OC[C@@H]1C[C@H]1CC#N)(c1ccccc1)c1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O

Using COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=Cc2cccnc2)cc1-c1ccccc1 to produce COC(=O)[C@H](CCSC)NC(=O)c1ccc(CCc2cccnc2)cc1-c1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=Cc2cccnc2)cc1-c1ccccc1 to produce COC(=O)[C@H](CCSC)NC(=O)c1ccc(CCc2cccnc2)cc1-c1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using CCN(CC1CCCC1)c1nc2c(cc1C#N)CCCC2 to produce CCN(CC1CCCC1)c1nc2c(cc1CN)CCCC2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CCN(CC1CCCC1)c1nc2c(cc1C#N)CCCC2 to produce CCN(CC1CCCC1)c1nc2c(cc1CN)CCCC2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using Cc1c([N+](=O)[O-])cnn1C to produce Cc1c(N)cnn1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using Cc1c([N+](=O)[O-])cnn1C to produce Cc1c(N)cnn1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using Cc1ccc2[nH]cc(CCN)c2c1, O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1 to produce Cc1ccc2[nH]cc(CCNc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])c2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, CCO

Using Cc1ccc2[nH]cc(CCN)c2c1, O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1 to produce Cc1ccc2[nH]cc(CCNc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])c2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

O, CCO

Using CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(I)c1, C#C[Si](C)(C)C to produce CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(C#C[Si](C)(C)C)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCN(CC)CC, C1CCOC1

Using CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(I)c1, C#C[Si](C)(C)C to produce CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(C#C[Si](C)(C)C)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCN(CC)CC, C1CCOC1

Using Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CC2)c(C)c1 to produce Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C)C)CC2)c(C)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CC2)c(C)c1 to produce Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)CCC4C)cc3C(=O)N(C)C)CC2)c(C)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CC(C)(C)OC(=O)c1sc([N+](=O)[O-])c(S(N)(=O)=O)c1CNS(C)(=O)=O to produce CS(=O)(=O)NCc1csc([N+](=O)[O-])c1S(N)(=O)=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1COCCO1

Using CC(C)(C)OC(=O)c1sc([N+](=O)[O-])c(S(N)(=O)=O)c1CNS(C)(=O)=O to produce CS(=O)(=O)NCc1csc([N+](=O)[O-])c1S(N)(=O)=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1COCCO1

Using O=C([O-])O, N#Cc1ncc(F)cc1F to produce O=Cc1ncc(F)cc1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClCCl

Using O=C([O-])O, N#Cc1ncc(F)cc1F to produce O=Cc1ncc(F)cc1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClCCl

Using O=C(c1ccccc1)c1ccc(O)cc1O, Cc1oc(-c2ccccc2)nc1CCl to produce Cc1oc(-c2ccccc2)nc1COc1ccc(C(=O)c2ccccc2)c(O)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CC(C)=O

Using O=C(c1ccccc1)c1ccc(O)cc1O, Cc1oc(-c2ccccc2)nc1CCl to produce Cc1oc(-c2ccccc2)nc1COc1ccc(C(=O)c2ccccc2)c(O)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CC(C)=O

Using CC(C)(C)OC(=O)Nc1cc(Cl)cc(Oc2cncnc2)c1 to produce Nc1cc(Cl)cc(Oc2cncnc2)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1COCCO1

Using CC(C)(C)OC(=O)Nc1cc(Cl)cc(Oc2cncnc2)c1 to produce Nc1cc(Cl)cc(Oc2cncnc2)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1COCCO1

Using O=[N+]([O-])c1c(Cl)nc(C2CC2)nc1Cl to produce Nc1c(Cl)nc(C2CC2)nc1Cl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using O=[N+]([O-])c1c(Cl)nc(C2CC2)nc1Cl to produce Nc1c(Cl)nc(C2CC2)nc1Cl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c(F)cccc1-2, II to produce CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c-2ccc(I)c1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c(F)cccc1-2, II to produce CCOc1ccc2c(c1F)C(F)(F)C(F)(F)c1c-2ccc(I)c1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CNC(=O)c1ccc(F)c2c(C(=O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12 to produce CNC(=O)c1ccc(F)c2c(C(O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using CNC(=O)c1ccc(F)c2c(C(=O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12 to produce CNC(=O)c1ccc(F)c2c(C(O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using [O-]c1ccccc1, CC(C)(C)C(=O)OC1Cn2c(-c3ccnc(S(C)(=O)=O)n3)c(-c3ccc(F)cc3)c(=O)n2C1 to produce O=c1c(-c2ccc(F)cc2)c(-c2ccnc(Oc3ccccc3)n2)n2n1CC(O)C2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using [O-]c1ccccc1, CC(C)(C)C(=O)OC1Cn2c(-c3ccnc(S(C)(=O)=O)n3)c(-c3ccc(F)cc3)c(=O)n2C1 to produce O=c1c(-c2ccc(F)cc2)c(-c2ccnc(Oc3ccccc3)n2)n2n1CC(O)C2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using COC(=O)c1cc(-c2ccc(F)cc2)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1 to produce CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc(F)cc3)cc2C(=O)O)cs1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1, CO

Using COC(=O)c1cc(-c2ccc(F)cc2)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1 to produce CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc(F)cc3)cc2C(=O)O)cs1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1, CO

Using CN, NC(=O)c1cc(-c2ccc(C=O)s2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12 to produce CNCc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CCCN5CCOCC5)CC4)c3c2)s1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClCCl, CO

Using CN, NC(=O)c1cc(-c2ccc(C=O)s2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12 to produce CNCc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CCCN5CCOCC5)CC4)c3c2)s1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClCCl, CO

Using CC(C)(C)OC(=O)n1cnc2ccc(F)cc21, CCOC(=O)c1ccc(Oc2nccnc2Cl)cc1 to produce O=C(c1ccc(Oc2nccnc2Cl)cc1)c1nc2ccc(F)cc2[nH]1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CC(C)(C)OC(=O)n1cnc2ccc(F)cc21, CCOC(=O)c1ccc(Oc2nccnc2Cl)cc1 to produce O=C(c1ccc(Oc2nccnc2Cl)cc1)c1nc2ccc(F)cc2[nH]1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using N=C(N)N, CCOC(=O)CC(=O)C(OCC)OCC to produce CCOC(OCC)c1cc(=O)[nH]c(N)n1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using N=C(N)N, CCOC(=O)CC(=O)C(OCC)OCC to produce CCOC(OCC)c1cc(=O)[nH]c(N)n1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO

Using CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O, N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21 to produce CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClCCl

Using CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O, N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21 to produce CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClCCl

Using CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(O)cc3C)c2)cc1F, OC1CCSCC1 to produce CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(OC4CCSCC4)cc3C)c2)cc1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(O)cc3C)c2)cc1F, OC1CCSCC1 to produce CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(OC4CCSCC4)cc3C)c2)cc1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

C1CCOC1

Using N#Cc1cccc(C2OC(O)c3cnccc32)c1 to produce N#Cc1cccc(C(O)c2ccncc2CO)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, CCO

Using N#Cc1cccc(C2OC(O)c3cnccc32)c1 to produce N#Cc1cccc(C(O)c2ccncc2CO)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, CCO

Using [OH-], CCCCCCCC1CCC(=O)O1 to produce CCCCCCCC(O)CCC(=O)[O-], please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using [OH-], CCCCCCCC1CCC(=O)O1 to produce CCCCCCCC(O)CCC(=O)[O-], please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using Cc1ccc(Cl)c(Oc2cc(C#N)cc(Cl)n2)c1F, O=C1CCC(=O)N1Br to produce N#Cc1cc(Cl)nc(Oc2c(Cl)ccc(CBr)c2F)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClC(Cl)(Cl)Cl

Using Cc1ccc(Cl)c(Oc2cc(C#N)cc(Cl)n2)c1F, O=C1CCC(=O)N1Br to produce N#Cc1cc(Cl)nc(Oc2c(Cl)ccc(CBr)c2F)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

ClC(Cl)(Cl)Cl

Using [NH2-], COc1ccc2ccncc2c1 to produce Nc1nccc2ccc(O)cc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, Cc1ccccc1C

Using [NH2-], COc1ccc2ccncc2c1 to produce Nc1nccc2ccc(O)cc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, Cc1ccccc1C

Using COC(=O)COc1cc(N)nc(C)c1C#N to produce COC(=O)COc1cc(N)nc(C)c1CN, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO, CO

Using COC(=O)COc1cc(N)nc(C)c1C#N to produce COC(=O)COc1cc(N)nc(C)c1CN, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO, CO

Using O=C(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1 to produce OC(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO, O

Using O=C(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1 to produce OC(c1ccc(Cl)cc1)c1cccnc1-n1ccnc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCO, O

Using C#Cc1ccccc1, Nc1cc(Br)ccc1[N+](=O)[O-] to produce Nc1cc(C#Cc2ccccc2)ccc1[N+](=O)[O-], please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, CC(C)NC(C)C

Using C#Cc1ccccc1, Nc1cc(Br)ccc1[N+](=O)[O-] to produce Nc1cc(C#Cc2ccccc2)ccc1[N+](=O)[O-], please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, CC(C)NC(C)C

Using CN(C)C=O, CCOC(=O)c1cc(OC)c2ccn(C3CC3)c2c1 to produce CCOC(=O)c1cc(OC)c2c(C=O)cn(C3CC3)c2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, O=P(Cl)(Cl)Cl

Using CN(C)C=O, CCOC(=O)c1cc(OC)c2ccn(C3CC3)c2c1 to produce CCOC(=O)c1cc(OC)c2c(C=O)cn(C3CC3)c2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CCOC(C)=O, O=P(Cl)(Cl)Cl

Using CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc([N+](=O)[O-])c(N)c3)c2)CC1 to produce CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(N)c(N)c3)c2)CC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO

Using CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc([N+](=O)[O-])c(N)c3)c2)CC1 to produce CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)Nc2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(N)c(N)c3)c2)CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.

CO