paper_id string | paper_title string | paper_text string | prompt list | completion list | pr-article string | topic string | __index_level_0__ int64 | generated_conversation list | conversation string |
|---|---|---|---|---|---|---|---|---|---|
10.1038/s41586-022-04637-w | Widespread brain receptor hides surprising mechanism of action | Abstract Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open their pores in response to binding of the agonist glutamate 1 , 2 , 3 . An ionic current through a single iGluR channel shows up to four discrete conductance levels (O1–O4) 4 , 5 , 6 . Higher conductance levels have been... | [
{
"content": "You are a helpful and knowledgeable journalist asking questions about a scientific paper.",
"role": "system"
},
{
"content": "[PAPERT-TITLE]\nWidespread brain receptor hides surprising mechanism of action\n[PAPER]\nAbstract Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-... | [
{
"content": "Journalist: That’s fascinating. So, if the relationship isn’t linear, what determines the level of conductivity? It seems like there’s more to it.",
"role": "assistant"
}
] | One of the most important molecules in the brain doesn't work quite the way scientists thought it did, according to new work by researchers at Columbia University Vagelos College of Physicians and Surgeons and Carnegie Mellon University. The results, published April 20 in Nature, may aid the development of a new genera... | Medicine | 2,451 | [
{
"content": "\n You are a helpful and knowledgeable journalist asking questions about a scientific paper. \n 1. Your questions encourage the researcher to place their paper in a proper societal and scientific context to the greatest possible degree.\n 2. Your questions focus on... | Journalist: Given your findings, could you elaborate on why the binding of glutamate to all four LBDs does not always result in the maximum channel conductance? What specific mechanisms or structural differences might be responsible for this behavior, and how do they differ from the common model where each subunit inde... |
10.1038/s41598-020-70924-z | Key gene identified in endometrial cancer could be targeted in future drug trial | Abstract ROR1 and ROR2 are receptor tyrosine kinases with altered expression in a range of cancers. Silencing ROR1 or ROR2 in different tumour types has been shown to inhibit proliferation and decrease metastatic potential. The aim of this study was to investigate the role of ROR1 and ROR2 in endometrial cancer via imm... | [
{
"content": "You are a helpful and knowledgeable journalist asking questions about a scientific paper.",
"role": "system"
},
{
"content": "[PAPERT-TITLE]\nKey gene identified in endometrial cancer could be targeted in future drug trial\n[PAPER]\nAbstract ROR1 and ROR2 are receptor tyrosine kinases ... | [
{
"content": "Journalist: \nHow did the study determine the role of ROR1 in endometrial cancer?",
"role": "assistant"
}
] | A new study has identified a key gene in aggressive endometrial cancer, which could lead to a targeted therapeutic strategy to improve survival rates. UNSW Sydney medical researchers have identified the gene known as ROR1 as a future target for therapeutic treatment of aggressive endometrial cancer. ROR1, which has a r... | Medicine | 9,334 | [
{
"content": "\n You are a helpful and knowledgeable journalist asking questions about a scientific paper. \n 1. Your questions encourage the researcher to place their paper in a proper societal and scientific context to the greatest possible degree.\n 2. Your questions focus on... | Journalist: Based on your findings, you observed a significant decrease in overall survival (OS) and progression-free survival (PFS) in patients with high ROR1 expression. Could you explain why you think ROR1 might be playing a more oncogenic role in endometrial cancer compared to ROR2, given that both receptors have b... |
dx.doi.org/10.1038/nature13186 | Research showcases most comprehensive wiring diagram of mammalian brain to date | Abstract Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding how the nervous system processes information at both local and global scales. However, with the singular exception of the C. elegans microscale connectome, there are no complete connectivity data sets in other species. Here ... | [
{
"content": "You are a helpful and knowledgeable journalist asking questions about a scientific paper.",
"role": "system"
},
{
"content": "[PAPERT-TITLE]\nResearch showcases most comprehensive wiring diagram of mammalian brain to date\n[PAPER]\nAbstract Comprehensive knowledge of the brain’s wiring... | [
{
"content": "Journalist: That’s a great overview. How was the Atlas created?",
"role": "assistant"
}
] | Researchers from the Allen Institute for Brain Science have published the first comprehensive, large-scale data set on how the brain of a mammal is wired, providing a groundbreaking data resource and fresh insights into how the nervous system processes information. Their landmark paper in this week's issue of the journ... | Medicine | 957 | [
{
"content": "\n You are a helpful and knowledgeable journalist asking questions about a scientific paper. \n 1. Your questions encourage the researcher to place their paper in a proper societal and scientific context to the greatest possible degree.\n 2. Your questions focus on... | Journalist: Your research presents a groundbreaking step in understanding the mesoscale connectome of the mouse brain, providing a comprehensive atlas that could significantly advance our knowledge in neuroscience. Given the complexity of the brain and the limitations in previous studies, I'm curious about the validati... |
10.1038/ncomms8955 | Microscopic rake doubles efficiency of low-cost solar cells | Abstract Morphology control of solution coated solar cell materials presents a key challenge limiting their device performance and commercial viability. Here we present a new concept for controlling phase separation during solution printing using an all-polymer bulk heterojunction solar cell as a model system. The key ... | [
{
"content": "You are a helpful and knowledgeable journalist asking questions about a scientific paper.",
"role": "system"
},
{
"content": "[PAPERT-TITLE]\nMicroscopic rake doubles efficiency of low-cost solar cells\n[PAPER]\nAbstract Morphology control of solution coated solar cell materials presen... | [
{
"content": "Journalist: That's interesting. Why do polymer-based solar cells typically have lower efficiency compared to silicon-based cells?",
"role": "assistant"
}
] | Researchers from the Department of Energy's SLAC National Accelerator Laboratory and Stanford University have developed a manufacturing technique that could double the electricity output of inexpensive solar cells by using a microscopic rake when applying light-harvesting polymers. When commercialized, this advance cou... | Chemistry | 384 | [
{
"content": "\n You are a helpful and knowledgeable journalist asking questions about a scientific paper. \n 1. Your questions encourage the researcher to place their paper in a proper societal and scientific context to the greatest possible degree.\n 2. Your questions focus on... | Journalist: Based on your research, you've developed a method called FLUENCE to enhance the crystallinity of polymer films in solution-coated solar cells. Could you explain how this method works in simpler terms? Specifically, how does the microstructured printing blade influence the fluid flow, and what is the mechani... |
10.1038/nmat4969 | Self-assembling nanoparticle arrays can switch between a mirror and a window | "Abstract Recently, there has been a drive to design and develop fully tunable metamaterials for app(...TRUNCATED) | [{"content":"You are a helpful and knowledgeable journalist asking questions about a scientific pape(...TRUNCATED) | [{"content":"Journalist: \nYou mentioned that controlling the spacing of nanoparticles was a major(...TRUNCATED) | "By finely tuning the distance between nanoparticles in a single layer, researchers have made a filt(...TRUNCATED) | Nano | 9,882 | [{"content":"\n You are a helpful and knowledgeable journalist asking questions about a s(...TRUNCATED) | "Journalist: Your work presents a fascinating approach to creating a tunable plasmonic platform that(...TRUNCATED) |
10.1038/s42003-021-02134-w | Virus infection cycle revealed in dynamic detail | "Abstract Many virus capsids undergo exquisitely choreographed maturation processes in their host ce(...TRUNCATED) | [{"content":"You are a helpful and knowledgeable journalist asking questions about a scientific pape(...TRUNCATED) | [{"content":"Journalist: \nYour research utilized plant-based technology to observe maturation in (...TRUNCATED) | "A critical process in the infection cycle of viruses has been revealed for the first time in dynami(...TRUNCATED) | Biology | 7,663 | [{"content":"\n You are a helpful and knowledgeable journalist asking questions about a s(...TRUNCATED) | "Journalist: Your work provides unprecedented insights into the maturation process of Nudaurelia cap(...TRUNCATED) |
10.1140/epjb/s10051-022-00305-0 | Ranking nanodevice functionality methods | "Abstract Our density functional theory analysis of charge transfer (CT) influence of annealed, pend(...TRUNCATED) | [{"content":"You are a helpful and knowledgeable journalist asking questions about a scientific pape(...TRUNCATED) | [{"content":"Journalist: Interesting. The study also highlights a link between molecular deformatio(...TRUNCATED) | "As the demand for nanodevices grows so too does the need to improve the functionality of such devic(...TRUNCATED) | Nano | 2,525 | [{"content":"\n You are a helpful and knowledgeable journalist asking questions about a s(...TRUNCATED) | "Journalist: Your research provides valuable insights into the influence of different functionalizat(...TRUNCATED) |
10.1007/s00439-021-02261-8 | New features of a gene defect that affects muzzle length and caudal vertebrae in dogs | "Abstract A frameshift deletion variant in the Wnt pathway gene dishevelled 2 ( DVL2 ) is associated(...TRUNCATED) | [{"content":"You are a helpful and knowledgeable journalist asking questions about a scientific pape(...TRUNCATED) | [{"content":"Journalist: Interesting. So, the DVL2 variant primarily affects the tail. But your stu(...TRUNCATED) | "A recent genetic study at the University of Helsinki provides new information on the occurrence of (...TRUNCATED) | Biology | 7,537 | [{"content":"\n You are a helpful and knowledgeable journalist asking questions about a s(...TRUNCATED) | "Journalist: Based on your study, you've identified that the DVL2 variant is associated with not jus(...TRUNCATED) |
10.1038/s41598-020-74223-5 | Scientists discover new organic compounds that could have helped form the first cells | "Abstract Prebiotic chemists often study how modern biopolymers, e.g., peptides and nucleic acids, c(...TRUNCATED) | [{"content":"You are a helpful and knowledgeable journalist asking questions about a scientific pape(...TRUNCATED) | [{"content":"Journalist: So, you're suggesting that life might not have started with the same compo(...TRUNCATED) | "Chemists studying how life started often focus on how modern biopolymers like peptides and nucleic (...TRUNCATED) | Biology | 1,168 | [{"content":"\n You are a helpful and knowledgeable journalist asking questions about a s(...TRUNCATED) | "Journalist: Given the importance of cyclic and acyclic forms in the oligomerization process, could (...TRUNCATED) |
10.1617/s11527-019-1387-0 | Finding the factors that most influence the steel corrosion in reinforced concrete | "Abstract The steel–concrete interface (SCI) is known to influence corrosion of steel in concrete.(...TRUNCATED) | [{"content":"You are a helpful and knowledgeable journalist asking questions about a scientific pape(...TRUNCATED) | [{"content":"Journalist: You mentioned that corrosion is caused by two main agents. Could you elabo(...TRUNCATED) | "Since the Egyptian pyramids and the Roman Coliseum were built, mankind has been searching for an af(...TRUNCATED) | Chemistry | 3,427 | [{"content":"\n You are a helpful and knowledgeable journalist asking questions about a s(...TRUNCATED) | "Journalist: Based on your methodology, it seems you've quantified the effects of various SCI charac(...TRUNCATED) |
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