Superpotion-DeepSeek-V3.2-Speciale

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A patient with sarcoidosis presents with thrombocytopenia (platelets 45,000). The spleen is palpable. Is the thrombocytopenia more likely due to hypersplenism/sequestration or autoimmune thrombocytopenia (ITP) associated with sarcoidosis? How does the bone marrow biopsy help differentiate these two mechanisms?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A patient with known sarcoidosis presents with moder...
A patient presents with recurrent sinusitis, asthma, and peripheral eosinophilia (>10%). They develop foot drop and cutaneous nodules. A biopsy shows extravascular granulomas and eosinophilic infiltration. What is the diagnosis (formerly Churg-Strauss), and what specific cardiac involvement is the leading cause of mort...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. The patient presents with a history of recurrent sin...
A patient with Sjögren’s presents with sudden hearing loss in the left ear. Audiometry confirms sensorineural hearing loss. Is this likely autoimmune vasculitis of the cochlear vessels, and what is the window of opportunity for steroid treatment to restore hearing?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A patient with a known diagnosis of Sjögren’s syndro...
It’s been 4 weeks since I got back from Ghana. I took Mefloquine the whole time. Today I woke up shaking uncontrollably, teeth chattering, the whole works. I took some Tylenol and now I feel fine, just tired. Was that a malaria attack or just a weird virus? Do I need to get tested if the fever is gone now?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. You are an adult who returned from Ghana (a malaria‑...
A 60-year-old male presents with a penile lesion. Biopsy shows a verrucous, papillomatous growth with broad, pushing borders into the underlying stroma. There is minimal cytologic atypia and no presence of koilocytes. This lesion is associated with a risk of transformation to invasive SCC but is distinct from giant con...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 60‑year‑old male presents with a penile lesion. Th...
A 15-year-old male presents with a painless, hard mass on the distal femur. X-ray shows a "sunburst" pattern and Codman’s triangle. What is the most likely malignancy, and where is the most common site of metastasis?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 15-year-old male presents with a painless, hard ma...
A 19-year-old college student presents with a "bad rash" on his trunk. He thinks it's from the dorm shower. He is very chatty, talks about his exams, his girlfriend, and his gym routine. He mentions he uses selenium sulfide shampoo for dandruff. The rash consists of hypopigmented macules that do not itch. A KOH prep sh...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 19‑year‑old healthy male presents with asymptomati...
I had a mastectomy on the right side three years ago. Lately, my right arm feels heavy, and my rings are tight on my fingers. My surgeon said they only took a 'few' lymph nodes (sentinel something?). Could this still be lymphedema this late in the game, and does it mean the cancer is back in the armpit?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. You are a patient who underwent a right-sided mastec...
A 13-year-old female presents with polyuria and polydipsia. Her random glucose is 210 mg/dL and HbA1c is 7.8%. She is not acidotic and has no ketones. She is non-obese. Autoantibodies (GAD65, IA-2) are negative. Her father and grandmother were diagnosed with "mild diabetes" in their teens. What is the likely diagnosis ...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 13-year-old non-obese female presents with polyuri...
A 65-year-old male with a history of asbestos exposure presents with a pleural mass. Biopsy shows a biphasic tumor with both epithelial and sarcomatoid components. The epithelial cells are positive for Calretinin, WT-1, and D2-40, and negative for TTF-1 and CEA. What is the diagnosis, and why is the distinction from me...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 65‑year‑old male with a known history of asbestos ...
Diff dx for podagra other than gout?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. Podagra refers to acute monoarthritis of the first m...
A 2-year-old with Down Syndrome is in the ICU for RSV bronchiolitis. He develops abdominal distension and vomiting. Abdominal X-ray shows dilated loops. He has a history of constipation but passed meconium within 48 hours of birth. A rectal biopsy performed previously was equivocal (ganglion cells present but sparse). ...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 2-year-old male with Down syndrome is in the ICU f...
A 25-year-old female presents with hemoptysis and dyspnea. Chest CT shows diffuse alveolar hemorrhage. Urinalysis shows hematuria and proteinuria. ANCA testing is positive for C-ANCA (PR3-ANCA). Biopsy of the nasal mucosa shows granulomatous inflammation and necrosis. What is the diagnosis?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. The patient is a young adult female with respiratory...
A 16-year-old phenotypic female presents with primary amenorrhea. Examination reveals breast development (Tanner stage IV) but scant pubic and axillary hair. Pelvic ultrasound shows an absent uterus and ovaries. Karyotype is 46,XY. What is the defect in the androgen receptor causing this presentation?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 16-year-old phenotypic female presents with primar...
A 32-year-old pregnant female presents with Hyperemesis Gravidarum. She has lost 10% of her pre-pregnancy weight. She has a history of Bulimia Nervosa in adolescence. How do you clinically differentiate between the physiological nausea of Hyperemesis Gravidarum and a relapse of psychogenic vomiting in pregnancy, consid...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 32-year-old pregnant female (gestational age unspe...
A bone marrow biopsy is performed on a 70-year-old male with monocytosis. The marrow is hypercellular with dysplastic granulopoiesis and megakaryocytes. The blast count is 3%. Cytogenetics reveals a normal karyotype, but molecular panels show mutations in TET2, SRSF2, and ASXL1. The defining feature is the persistent m...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 70-year-old male presents with persistent monocyto...
A patient presents with gross hematuria and clot retention. They are receiving a continuous bladder irrigation (CBI). Despite the CBI, the hemoglobin drops, and the patient becomes hypertensive with bradycardia. Identify the complication of "TURP syndrome" or irrigation fluid absorption (if using glycine/water) versus ...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A patient with gross hematuria and clot retention is...
A 34-year-old female with a history of Systemic Lupus Erythematosus (SLE) presents with severe headache and neck stiffness after starting a course of ibuprofen for joint pain. CSF shows a neutrophilic pleocytosis with normal glucose and cultures are negative. How do you distinguish between Drug-Induced Aseptic Meningit...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 34-year-old woman with systemic lupus erythematosu...
A 13-year-old female presents with daytime urge incontinence and nocturnal enuresis. She adopts a squatting posture where she presses her heel into her perineum (Vincent’s curtsy) to defer voiding. Uroflowmetry demonstrates a staccato voiding pattern. What is the diagnosis, and what is the primary goal of biofeedback t...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 13-year-old female presents with classic symptoms ...
A 50-year-old male receiving chemotherapy for acute myeloid leukemia (AML) remains febrile despite 5 days of broad-spectrum antibacterial coverage. A CT of the chest reveals a nodule with a surrounding ground-glass halo ("halo sign"). Serum galactomannan is positive. What is the most likely diagnosis, and what is the m...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 50-year-old male with acute myeloid leukemia (AML)...
Pt presented w/ fevers x5 days. recent travel India. Smear read as 'P. vivax' by tech but I'm looking at it and the rings look tiny and there's multiple per cell. No Schuffner dots seen. Pt mental status slightly boggy. Could this be a mixed infection or misread Falciparum? Should I start IV or stick to oral?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A previously healthy patient presents with a 5-day h...
A 50-year-old male smoker presents with severe, burning pain in his hands and feet, accompanied by ulcerations on the digits. The pulses in the radial and ulnar arteries are absent, but the brachial pulses are preserved. Angiography shows segmental occlusions of the small and medium-sized arteries with "corkscrew" coll...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 50-year-old male with a history of smoking present...
A 21-year-old male is brought to the ER after using a synthetic drug at a party. He is aggressive, exhibits vertical nystagmus, and has a high tolerance for pain. Which dissociative anesthetic agent, acting as an NMDA receptor antagonist, is most likely responsible?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 21-year-old male presents with acute behavioral an...
A 45-year-old female presents with a firm, fixed, painless goiter and stridor. She is euthyroid. A CT scan shows tracheal compression and encasement of the carotid vessels. Biopsy reveals dense fibrous tissue with an abundance of IgG4-positive plasma cells. What is the likely diagnosis, and how does this condition clin...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 45-year-old female presents with a firm, fixed, pa...
A 28-year-old male with a native history of Focal Segmental Glomerulosclerosis (FSGS) receives a living related kidney. Three weeks post-transplant, he develops massive proteinuria (8g/day) and peripheral edema. An allograft biopsy shows diffuse foot process effacement on electron microscopy but normal light microscopy...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 28-year-old male with a history of primary focal s...
Pt is 22yo M, IVDU (heroin/fent), brought by EMS found down. Narcan x2 with response. Awake now. C/o pleuritic CP. Vals: HR 110, BP 100/60, SpO2 92%. CXR multisegmental septic emboli? peripheral nodules. Pt wants to leave AMA. Need risk strat regarding tricuspid veg/septic EP vs simple asp PNA.	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 22‑year‑old male with a history of intravenous dru...
A 70-year-old male presents with heart failure with preserved ejection fraction (HFpEF), macroglossia, and bilateral carpal tunnel syndrome. An ECG shows low voltage QRS complexes despite severe left ventricular wall thickening on Echo. What is the most likely diagnosis, and what definitive biopsy-free imaging modality...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. The patient is a 70-year-old male presenting with he...
A newborn presents with hypotonia, hepatomegaly, and craniofacial abnormalities (large fontanelles, high forehead). Plasma levels of very long-chain fatty acids (VLCFA), phytanic acid, and bile acid intermediates are elevated. What is the diagnosis of this peroxisomal biogenesis disorder, and what is the prognosis rega...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. The newborn presents with hypotonia, hepatomegaly, a...
A 40-year-old male with newly diagnosed HIV (CD4 25) and active pulmonary TB is started on RIPE therapy. Two weeks later, he starts Antiretroviral Therapy (ART). Ten days after starting ART, his fever returns, and his cervical lymph nodes enlarge rapidly, becoming fluctuant. Differentiate between TB treatment failure a...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 40-year-old male with advanced HIV (CD4 count 25 c...
My husband has been acting really weird lately. He has liver cirrhosis (from alcohol, but he quit 2 years ago). Yesterday he was fine, but today he is confused, forgot where the bathroom was, and his hands are shaking when he tries to hold a cup—it looks like a flapping tremor. He hasn't had a drink. He has been consti...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. Your husband has a known history of alcohol-related ...
A 14-year-old male presents with new-onset diabetes. He has optic atrophy and diabetes insipidus (polyuria/polydipsia persisting despite glycemic control). What is the unifying genetic diagnosis (syndrome), and what is the prognosis for beta-cell function?	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 14‑year‑old male presents with new‑onset diabetes ...
An 8-year-old girl presents with progressive weakness starting in her legs and moving to her arms over the last 3 days. She had a viral gastrointestinal illness 2 weeks ago. Reflexes are absent in the lower extremities. CSF analysis shows elevated protein with a normal white blood cell count (albuminocytologic dissocia...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. An 8-year-old girl presents with a 3-day history of ...
A 4-month-old infant of Ashkenazi Jewish descent presents with generalized hypotonia and significant head lag. The head circumference has crossed from the 50th to the 98th percentile over the last two months. There is no hepatosplenomegaly or cherry-red spot on fundoscopy. Visual tracking is poor. What is the primary l...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. A 4-month-old infant of Ashkenazi Jewish descent pre...
A patient with a known 4mm non-obstructing lower pole stone presents with severe flank pain. CT shows the stone is unchanged in position with no hydronephrosis. Diagnostically, how do you differentiate between true renal colic and musculoskeletal pain or radiculopathy in the presence of an incidental non-obstructing st...	<think> We need to analyze the user's query. The query type is medical diagnostic; seeking a diagnosis or immediate next steps. We will utilize medical reasoning and analysis to assist the query. We'll begin by precisely summarizing the patient presentation. The patient is known to have a 4 mm non‑obstructing ...

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Superpotion-DeepSeek-V3.2.Speciale is a dataset containing structured medical reasoning responses, testing the limits of DeepSeek V3.2 Speciale's medical reasoning skills across a wide variety of medical disciplines and tasks!

This dataset contains:

28.8k synthetically generated medical prompts, with all responses generated using DeepSeek V3.2 Speciale.
Structured medical reasoning: Superpotion uses organized, informative, efficient medical reasoning responses.
- 60% of prompts are explanatory: the user asks for a pathophysiological explanation, pharmacological mechanism, anatomical description, etc. In response, the model uses reasoning to define the underlying physiological or anatomical principle and explain the underlying mechanism and causal chain, then responds to the user with a medical explanation.
- 20% of prompts are management: the user asks how to treat, manage, or screen a confirmed condition. In response, the model uses reasoning to assess the situation and identify specific risks and points of emphasis, then responds to the user with the recommended therapy and any notable contraindications, side effects, or alternatives.
- 15% of prompts are diagnostic: the user asks for a diagnosis or immediate next steps in response to a medical case. In response, the model uses reasoning to identify key pivot points, identify the leading hypothesis and contrast it with alternative explanations, then responds to the user with the final clinical impression and the specific actions required.
- 5% of prompts are miscellaneous: medical queries not fitting the above categories. These queries include structured tasks such as SOAP note generation as well as general knowledge inquiries. The model responds according to the user's request, favoring concise and evidence-focused reasoning before providing the final response.
Cut token costs: efficient, structured styles of reasoning produces shorter, faster, organized responses.
Wide-ranging specialties: the Superpotion dataset provides challenging queries across a variety of medical disciplines and patient types.
- All areas of the human body: traditional disciplines of internal medicine and medical diagnosis are accompanied by queries on dental, dermatology, genetics, nutrition, opthamology, orthopedics, psychiatry, radiology, sleep medicine, sports medicine, surgery, toxicology, and more!
- All types of people: patient variety is emphasized across all question types! Specific points of emphasis include age, race, gender, sexuality, neurodivergence, background, medical history, occupation, and body type. (Note that all queries and responses are synthetic; recommended care in all areas is a test of DeepSeek V3.2 Speciale's medical reasoning strengths and weaknesses.)
- Deep dives on specific conditions: Superpotion contains queries on a wide variety of many specific diseases and disorders, challenging DeepSeek V3.2 Speciale to handle both common and rare disorders from many medical subfields.
- Linguistic prompt variety: Prompts offer a mix of first-person and third-person perspectives, complex queries and simple problems, high-noise and low-noise information, and reflect a variety of medical settings. Useful for a variety of professional and personal medical queries!
Prioritize diagnostic usefulness: Superpotion emphasizes not withholding information from the user, professional medical language, diagnostic specificity, statistical rationality, and succinct responses.

Initial responses from DeepSeek V3.2 Speciale have been edited for structure, style, and brevity, but not for medical response content; Superpotion strives to accurately represent the medical reasoning abilities of V3.2 Speciale. Responses are synthetic and have not been reviewed by human professionals. Superpotion is presented as-is to be used at your discretion.

Users should consider applying their own sub-filtering and manual examination of the dataset before use in training.

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