_id stringlengths 4 9 | title stringlengths 2 300 | text stringlengths 174 10k | bge_m3_sparse_vector stringlengths 833 16.5k |
|---|---|---|---|
1122279 | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. | BACKGROUND Endothelium-dependent modulation of coronary tone is impaired in the collateral-dependent coronary microcirculation. We used a porcine model of chronic coronary occlusion and collateral development to evaluate the hypothesis that exercise training enhances endothelium-mediated relaxation and increases endoth... | {"8678": 0.030364990234375, "20572": 0.006801605224609375, "136498": 0.04803466796875, "357": 0.042877197265625, "246": 0.0782470703125, "2347": 0.1605224609375, "52853": 0.1861572265625, "181063": 0.1510009765625, "17055": 0.17138671875, "109728": 0.1611328125, "1294": 0.05712890625, "70334": 0.1580810546875, "566": 0... |
1127562 | Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans | Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clearance in both Caenorhabditis elegans and mammalian cells. Loss of srgp-1 function results in improved engul... | {"19335": 0.12255859375, "8969": 0.140625, "120087": 0.07464599609375, "85825": 0.206298828125, "25545": 0.098388671875, "34735": 0.2354736328125, "2160": 0.09844970703125, "214": 0.04949951171875, "38750": 0.19921875, "1295": 0.11651611328125, "337": 0.053253173828125, "34204": 0.0035228729248046875, "60875": 0.075927... |
1145473 | Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. | Down syndrome (DS) children have a high frequency of acute megakaryoblastic leukemia (AMKL) in early childhood. At least 2 in utero genetic events are required, although not sufficient, for DS-AMKL: trisomy 21 (T21) and N-terminal-truncating GATA1 mutations. To investigate the role of T21 in DS-AMKL, we compared second... | {"49472": 0.2607421875, "194923": 0.198486328125, "13526": 0.2073974609375, "20020": 0.1998291015625, "765": 0.059112548828125, "11192": 0.11346435546875, "12478": 0.1781005859375, "944": 0.1141357421875, "27771": 0.05438232421875, "85691": 0.1258544921875, "721": 0.0809326171875, "344": 0.037933349609375, "6635": 0.05... |
1148122 | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli | Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little. We have developed a combined experimental/comput... | {"9626": 0.10687255859375, "144057": 0.079345703125, "101412": 0.25439453125, "18231": 0.2286376953125, "111": 0.03778076171875, "6": 0.0179595947265625, "202444": 0.29248046875, "83": 0.01209259033203125, "9879": 0.1009521484375, "2967": 0.1220703125, "23": 0.0179290771484375, "333": 0.0704345703125, "25443": 0.095031... |
1153655 | Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. | The importance of genetic factors in etiology of chronic lymphocytic leukemia (CLL) is suggested by family and population studies. However, the spectrum of malignancies sharing common genetic factors with CLL and the effects of sex and age on familial risk are unknown. We used the Swedish Family-Cancer Database to test... | {"131011": 0.16552734375, "101412": 0.2666015625, "120103": 0.22412109375, "82": 0.071533203125, "14": 0.07568359375, "25443": 0.07763671875, "184843": 0.1695556640625, "238757": 0.158447265625, "31": 0.057159423828125, "2408": 0.08563232421875, "9523": 0.00749969482421875, "39983": 0.127685546875, "7605": 0.1331787109... |
1156322 | Collagen/Polypropylene composite mesh biocompatibility in abdominal wall reconstruction. | BACKGROUND Intraperitoneal placement of polypropylene mesh leads to extensive visceral adhesions and is contraindicated. Different coatings are used to improve polypropylene mesh properties. Collagen is a protein with unique biocompatibility and cell ingrowth enhancement potential. A novel acetic acid extracted collage... | {"8678": 0.07427978515625, "20572": 0.051727294921875, "136498": 0.0921630859375, "155036": 0.1165771484375, "17152": 0.105712890625, "40491": 0.1575927734375, "3687": 0.124267578125, "35874": 0.137939453125, "225657": 0.2498779296875, "1151": 0.1356201171875, "163": 0.2216796875, "1495": 0.186279296875, "37105": 0.064... |
1171121 | Microvessel Density and Status of p53 Protein as Potential Prognostic Factors for Adjuvant Anthracycline Chemotherapy in Retrospective Analysis of Early Breast Cancer Patients Group | A considerable subgroup of patients with early breast cancer does not address benefits of anthracycline based chemotherapy. The aim of this retrospective study was to investigate the effect of microvessel density (MVD) and status of p53 protein on 5-year disease free survival (DFS) in the group of breast cancer patient... | {"150675": 0.0989990234375, "1614": 0.06781005859375, "51588": 0.1055908203125, "111": 0.00965118408203125, "60264": 0.101318359375, "39395": 0.12841796875, "57262": 0.2193603515625, "27968": 0.184326171875, "14602": 0.007904052734375, "959": 0.059844970703125, "29823": 0.08148193359375, "72382": 0.1778564453125, "142"... |
1173667 | Ranking of elimination feasibility between malaria-endemic countries | Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and combined to provide an objective, relati... | {"135634": 0.23828125, "21647": 0.09173583984375, "297": 0.0081939697265625, "1295": 0.032562255859375, "13453": 0.11505126953125, "3658": 0.194580078125, "6232": 0.275634765625, "241": 0.062103271484375, "10541": 0.2122802734375, "120639": 0.10552978515625, "7663": 0.17626953125, "214243": 0.2047119140625, "9": 0.0435... |
1180972 | Genetics of obesity in adult adoptees and their biological siblings. | An adoption study of genetic effects on obesity in adulthood was carried out in which adoptees separated from their natural parents very early in life were compared with their biological full and half siblings reared by their natural parents. The adoptees represented four groups who by sampling from a larger population... | {"180064": 0.2491455078125, "35187": 0.162109375, "101412": 0.2445068359375, "93425": 0.220458984375, "98": 0.0716552734375, "150009": 0.262939453125, "2481": 0.19482421875, "23": 0.04132080078125, "25171": 0.1556396484375, "44462": 0.132080078125, "175100": 0.0307159423828125, "1810": 0.01332855224609375, "30666": 0.1... |
1191830 | 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. | OBJECTIVE The 1987 American College of Rheumatology (ACR; formerly the American Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticised for their lack of sensitivity in early disease. This work was undertaken to develop new classification criteria for RA. METHODS A joint worki... | {"35988": 0.124755859375, "15301": 0.1475830078125, "441": 0.0975341796875, "169813": 0.052398681640625, "22059": 0.1865234375, "15672": 0.07904052734375, "29693": 0.140380859375, "111": 0.03045654296875, "80658": 0.0975341796875, "316": 0.14501953125, "257": 0.036590576171875, "25443": 0.06793212890625, "284": 0.04852... |
1192458 | A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. | Cigarette smoke and smokeless tobacco extracts contain multiple carcinogenic compounds, but little is known about the mechanisms by which tumors develop and progress upon chronic exposure to carcinogens such as those present in tobacco products. Here, we examine the effects of smokeless tobacco extracts on human oral f... | {"2079": 0.090087890625, "208": 0.1585693359375, "53417": 0.14892578125, "2614": 0.202392578125, "350": 0.1337890625, "136": 0.061248779296875, "9393": 0.269287109375, "47": 0.139892578125, "402": 0.18310546875, "13400": 0.1959228515625, "125663": 0.259765625, "70541": 0.08612060546875, "48716": 0.10662841796875, "2258... |
1196631 | ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells | Antigen cross-presentation by dendritic cells (DCs) is thought to play a critical role in driving a polyclonal and durable T cell response against cancer. It follows, therefore, that the capacity of emerging immunotherapeutic agents to orchestrate tumour eradication may depend on their ability to induce antigen cross-p... | {"8332": 0.1746826171875, "1409": 0.1939697265625, "41421": 0.1905517578125, "55247": 0.2491455078125, "390": 0.0272064208984375, "8": 0.11859130859375, "29887": 0.1650390625, "9523": 0.05938720703125, "38750": 0.1787109375, "7": 0.11444091796875, "21960": 0.1826171875, "16": 0.0269317626953125, "17569": 0.080627441406... |
1203035 | Basal keratinocyte tetrasomy in low-grade squamous intra-epithelial lesions of the cervix is restricted to high and intermediate risk HPV infection but is not type-specific | Human papillomavirus (HPV) infection appears to be an early event in cervical carcinogenesis with additional abnormalities being required for biological transformation. We have analysed 179 low-grade cervical squamous intra-epithelial lesions (SILs) and 15 normal cervices for the presence of HPV using both in situ hybr... | {"28076": 0.1351318359375, "153688": 0.23681640625, "51081": 0.168212890625, "76912": 0.20849609375, "36599": 0.2216796875, "856": 0.263916015625, "159634": 0.23388671875, "135179": 0.147705078125, "47": 0.0096435546875, "186": 0.033660888671875, "39395": 0.1431884765625, "19732": 0.1123046875, "6641": 0.15087890625, "... |
1215116 | “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor | Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases such as lymphatic filariasis, onchocerciasis, guinea worm, ... | {"9578": 0.08343505859375, "70": 0.028411865234375, "11015": 0.1309814453125, "6626": 0.11431884765625, "8": 0.12548828125, "23662": 0.152099609375, "7": 0.11810302734375, "2685": 0.039276123046875, "765": 0.08526611328125, "2809": 0.04437255859375, "88551": 0.1607666015625, "69307": 0.2191162109375, "9035": 0.14257812... |
1220287 | FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. | Huntington disease (HD) is a genetic neurodegenerative disorder for which there is currently no cure and no way to stop or even slow the brain changes it causes. In the present study, we aimed to investigate whether FTY720, the first approved oral therapy for multiple sclerosis, may be effective in HD models and eventu... | {"136392": 0.251708984375, "42562": 0.30078125, "70997": 0.1986083984375, "16291": 0.28857421875, "83": 0.06201171875, "10": 0.0161590576171875, "101412": 0.1885986328125, "37817": 0.1160888671875, "112": 0.062164306640625, "48281": 0.10498046875, "4935": 0.00714111328125, "171986": 0.13330078125, "2685": 0.01445007324... |
1225513 | Specificity Residues Determine Binding Affinity for Two-Component Signal Transduction Systems | UNLABELLED Two-component systems (TCS) comprise histidine kinases and their cognate response regulators and allow bacteria to sense and respond to a wide variety of signals. Histidine kinases (HKs) phosphorylate and dephosphorylate their cognate response regulators (RRs) in response to stimuli. In general, these reacti... | {"8274": 0.1336669921875, "89549": 0.1705322265625, "80020": 0.1832275390625, "397": 0.08135986328125, "32964": 0.2034912109375, "277": 0.15576171875, "54137": 0.26953125, "76519": 0.201904296875, "20499": 0.177001953125, "294": 0.16748046875, "16": 0.010772705078125, "48402": 0.0943603515625, "1919": 0.103271484375, "... |
1226452 | hnRNP A1 associates with telomere ends and stimulates telomerase activity. | Telomerase is a ribonucleoprotein enzyme complex that reverse-transcribes an integral RNA template to add short DNA repeats to the 3'-ends of telomeres. G-quadruplex structure in a DNA substrate can block its extension by telomerase. We have found that hnRNP A1--which was previously implicated in telomere length regula... | {"9344": 0.21923828125, "13450": 0.2314453125, "78728": 0.271484375, "83": 0.11871337890625, "10": 0.04339599609375, "105598": 0.176513671875, "539": 0.05023193359375, "11030": 0.032623291015625, "31": 0.01654052734375, "80000": 0.12396240234375, "73": 0.08837890625, "193807": 0.1925048828125, "13": 0.05706787109375, "... |
1227277 | Rapamycin passes the torch: a new generation of mTOR inhibitors | Mammalian target of rapamycin (mTOR) is an atypical protein kinase that controls growth and metabolism in response to nutrients, growth factors and cellular energy levels, and it is frequently dysregulated in cancer and metabolic disorders. Rapamycin is an allosteric inhibitor of mTOR, and was approved as an immuno-sup... | {"101860": 0.1793212890625, "38820": 0.150390625, "30388": 0.275146484375, "111": 0.00885772705078125, "29892": 0.21923828125, "35624": 0.2354736328125, "6333": 0.259765625, "39": 0.112060546875, "27010": 0.330810546875, "83": 0.06842041015625, "10": 0.0556640625, "46280": 0.1776123046875, "21308": 0.2083740234375, "24... |
1234098 | Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium | Bacterial pathogens produce complex carbohydrate capsules to protect against bactericidal immune molecules. Paradoxically, the pneumococcal capsule sensitizes the bacterium to antimicrobial peptides found on epithelial surfaces. Here we show that upon interaction with antimicrobial peptides, encapsulated pneumococci su... | {"86196": 0.115478515625, "26206": 0.1326904296875, "141": 0.05145263671875, "60875": 0.1126708984375, "62976": 0.1966552734375, "27489": 0.12274169921875, "27140": 0.1258544921875, "2258": 0.1124267578125, "837": 0.12115478515625, "99735": 0.1685791015625, "13": 0.0775146484375, "150143": 0.259765625, "7": 0.120056152... |
1241113 | The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin | Scribble (Scrib) is a conserved polarity protein required in Drosophila melanogaster for synaptic function, neuroblast differentiation, and epithelial polarization. It is also a tumor suppressor. In rodents, Scrib has been implicated in receptor recycling and planar polarity but not in apical/basal polarity. We now sho... | {"38213": 0.260009765625, "14": 0.217529296875, "73163": 0.38427734375, "15": 0.02801513671875, "61278": 0.1885986328125, "11049": 0.34814453125, "16": 0.00799560546875, "83": 0.07366943359375, "118684": 0.169921875, "71": 0.039276123046875, "160": 0.1834716796875, "320": 0.18896484375, "2481": 0.0694580078125, "21308"... |
1243475 | Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype. | A characteristic feature of anaplastic large cell lymphoma is the significant repression of the T-cell expression program despite its T-cell origin. The reasons for this down-regulation of T-cell phenotype are still unknown. To elucidate whether epigenetic mechanisms are responsible for the loss of the T-cell phenotype... | {"62816": 0.1505126953125, "48242": 0.1180419921875, "60213": 0.1507568359375, "111": 0.00928497314453125, "3877": 0.1484375, "72325": 0.2255859375, "1771": 0.0751953125, "21334": 0.15869140625, "38750": 0.189697265625, "238757": 0.162109375, "8945": 0.156005859375, "83": 0.031280517578125, "88551": 0.09344482421875, "... |
1256116 | YEASTRACT: providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface | The YEAst Search for Transcriptional Regulators And Consensus Tracking (YEASTRACT) information system (http://www.yeastract.com) was developed to support the analysis of transcription regulatory associations in Saccharomyces cerevisiae. Last updated in June 2010, this database contains over 48,200 regulatory associatio... | {"581": 0.02508544921875, "86793": 0.270751953125, "284": 0.1900634765625, "271": 0.2276611328125, "33086": 0.1962890625, "100": 0.044952392578125, "60532": 0.167724609375, "59478": 0.1939697265625, "289": 0.01161956787109375, "47881": 0.2440185546875, "22230": 0.1143798828125, "3493": 0.12005615234375, "39215": 0.1391... |
1259280 | Mechanisms that Specify Promoter Nucleosome Location and Identity | The chromatin architecture of eukaryotic gene promoters is generally characterized by a nucleosome-free region (NFR) flanked by at least one H2A.Z variant nucleosome. Computational predictions of nucleosome positions based on thermodynamic properties of DNA-histone interactions have met with limited success. Here we sh... | {"17656": 0.10321044921875, "38657": 0.15673828125, "73": 0.1357421875, "159958": 0.241455078125, "1175": 0.0914306640625, "1153": 0.1632080078125, "1410": 0.10772705078125, "22293": 0.16943359375, "8891": 0.231689453125, "23962": 0.1534423828125, "137567": 0.056243896484375, "62816": 0.130859375, "241454": 0.208374023... |
1259359 | HIV seropositivity and tuberculosis in a large general hospital in Malawi. | The incidence of the acquired immunodeficiency syndrome (AIDS) in Malawi is one of the highest in Central Africa. Since tuberculosis is an important initial manifestations of the disease, consecutive patients admitted to the tuberculosis (TB) wards of Zomba General Hospital, Malawi, were asked for permission to undergo... | {"136667": 0.1717529296875, "3956": 0.08062744140625, "163629": 0.131591796875, "43766": 0.1812744140625, "31": 0.08831787109375, "112": 0.15087890625, "11044": 0.1650390625, "33": 0.01027679443359375, "194923": 0.1668701171875, "181696": 0.265625, "23": 0.027984619140625, "16522": 0.169189453125, "2452": 0.28491210937... |
1263446 | Determinants of neonatal mortality in Indonesia | BACKGROUND Neonatal mortality accounts for almost 40 per cent of under-five child mortality, globally. An understanding of the factors related to neonatal mortality is important to guide the development of focused and evidence-based health interventions to prevent neonatal deaths. This study aimed to identify the deter... | {"8678": 0.06890869140625, "20572": 0.042816162109375, "136498": 0.08172607421875, "799": 0.15087890625, "2477": 0.210693359375, "1803": 0.1514892578125, "67573": 0.1966552734375, "2481": 0.10455322265625, "15426": 0.08349609375, "100": 0.05316162109375, "39555": 0.00803375244140625, "1112": 0.058502197265625, "117": 0... |
1265945 | High density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis | Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenti... | {"52597": 0.177490234375, "13": 0.0264892578125, "113458": 0.13916015625, "125413": 0.2305908203125, "96335": 0.114990234375, "62548": 0.136474609375, "184843": 0.1583251953125, "41036": 0.136474609375, "18023": 0.11474609375, "31667": 0.022003173828125, "337": 0.0633544921875, "8420": 0.1656494140625, "70997": 0.17187... |
1275505 | High-Threshold Mechanosensitive Ion Channels Blocked by a Novel Conopeptide Mediate Pressure-Evoked Pain | Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons. One conopeptide analogue, termed NMB-1 for noxious mechanosensation blocker 1, selectively inhibits ... | {"59784": 0.043243408203125, "51529": 0.06976318359375, "233239": 0.1212158203125, "18231": 0.1361083984375, "124": 0.089599609375, "2832": 0.062347412109375, "163839": 0.201904296875, "74842": 0.242431640625, "31": 0.02325439453125, "30145": 0.1270751953125, "77391": 0.149169921875, "21968": 0.13671875, "8080": 0.1022... |
1281769 | Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants | Bardet-Biedl syndrome, BBS, is a rare autosomal recessive disorder with clinical presentations including polydactyly, retinopathy, hyperphagia, obesity, short stature, cognitive impairment, and developmental delays. Disruptions of BBS proteins in a variety of organisms impair cilia formation and function and the multi-... | {"3253": 0.244384765625, "3667": 0.2919921875, "9": 0.11285400390625, "16882": 0.188232421875, "297": 0.22509765625, "141": 0.238037109375, "194923": 0.2578125, "4": 0.04913330078125, "335": 0.19775390625, "20429": 0.33642578125, "83": 0.11083984375, "10": 0.0592041015625, "41207": 0.1888427734375, "1809": 0.1491699218... |
1283401 | Fiji: an open-source platform for biological-image analysis | Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis. Fiji uses modern software engineering practices to combine powerful software libraries with a broad range of scripting languages to enable rapid prototyping of image-processing algorithms. Fiji facilitates the transf... | {"3698": 0.2578125, "658": 0.3076171875, "83": 0.1063232421875, "10": 0.06231689453125, "113068": 0.1983642578125, "111": 0.0212554931640625, "70": 0.01032257080078125, "5700": 0.1429443359375, "9803": 0.1290283203125, "60427": 0.142578125, "10975": 0.224365234375, "22710": 0.2076416015625, "1375": 0.2607421875, "16239... |
1285713 | Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. | Extensive evidence implicates activation of the lipid phosphatidylinositide 3-kinase (PI3K) pathway in the genesis and progression of various human cancers. PI3K inhibitors thus have considerable potential as molecular cancer therapeutics. Here, we detail the pharmacologic properties of a prototype of a new series of i... | {"41745": 0.0650634765625, "272": 0.01001739501953125, "77950": 0.1370849609375, "17914": 0.0811767578125, "34704": 0.11419677734375, "202951": 0.167236328125, "53073": 0.06561279296875, "16392": 0.07659912109375, "29870": 0.06646728515625, "61054": 0.08160400390625, "112": 0.0276947021484375, "5691": 0.1278076171875, ... |
1286352 | Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. | The type II clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system has emerged recently as a powerful method to manipulate the genomes of various organisms. Here, we report a toolbox for high-efficiency genome engineering of Drosophila melanogaster consisting of transgenic Cas... | {"10644": 0.1732177734375, "1995": 0.1812744140625, "234737": 0.20361328125, "297": 0.034881591796875, "186085": 0.1451416015625, "1940": 0.06610107421875, "65421": 0.18994140625, "71": 0.0311279296875, "16610": 0.1602783203125, "17923": 0.07037353515625, "39670": 0.17724609375, "21068": 0.0199432373046875, "119140": 0... |
1287809 | Cost-effectiveness of 10-Year Risk Thresholds for Initiation of Statin Therapy for Primary Prevention of Cardiovascular Disease. | IMPORTANCE The American College of Cardiology and the American Heart Association (ACC/AHA) cholesterol treatment guidelines have wide-scale implications for treating adults without history of atherosclerotic cardiovascular disease (ASCVD) with statins. OBJECTIVE To estimate the cost-effectiveness of various 10-year ASC... | {"195798": 0.10516357421875, "113786": 0.0307464599609375, "15672": 0.0469970703125, "29693": 0.11248779296875, "23660": 0.0977783203125, "25443": 0.0526123046875, "136": 0.028106689453125, "70": 0.028076171875, "60861": 0.12371826171875, "56187": 0.06866455078125, "284": 0.03826904296875, "13709": 0.161865234375, "64"... |
1292369 | Biochemical Properties of Highly Neuroinvasive Prion Strains | Infectious prions propagate from peripheral entry sites into the central nervous system (CNS), where they cause progressive neurodegeneration that ultimately leads to death. Yet the pathogenesis of prion disease can vary dramatically depending on the strain, or conformational variant of the aberrantly folded and aggreg... | {"360": 0.08673095703125, "17928": 0.18798828125, "5565": 0.11126708984375, "223": 0.048187255859375, "494": 0.2474365234375, "5245": 0.2408447265625, "175648": 0.188232421875, "67": 0.04534912109375, "1295": 0.07647705078125, "117": 0.00928497314453125, "94266": 0.1087646484375, "42805": 0.1640625, "15271": 0.07342529... |
1320137 | The twin-arginine translocation (Tat) protein export pathway | The twin-arginine translocation (Tat) protein export system is present in the cytoplasmic membranes of most bacteria and archaea and has the highly unusual property of transporting fully folded proteins. The system must therefore provide a transmembrane pathway that is large enough to allow the passage of structured ma... | {"138241": 0.2337646484375, "91723": 0.1822509765625, "85963": 0.1719970703125, "3900": 0.138916015625, "87632": 0.1829833984375, "618": 0.1719970703125, "257": 0.2139892578125, "21308": 0.253662109375, "31255": 0.25244140625, "5426": 0.1767578125, "13379": 0.09991455078125, "23": 0.016326904296875, "19932": 0.03286743... |
1322614 | New developments in the ATSAS program package for small-angle scattering data analysis | New developments in the program package ATSAS (version 2.4) for the processing and analysis of isotropic small-angle X-ray and neutron scattering data are described. They include (i) multiplatform data manipulation and display tools, (ii) programs for automated data processing and calculation of overall parameters, (ii... | {"2356": 0.106689453125, "34754": 0.1695556640625, "7": 0.015533447265625, "23": 0.021331787109375, "1528": 0.1927490234375, "98169": 0.225830078125, "17672": 0.215576171875, "93818": 0.326904296875, "15": 0.0036449432373046875, "46354": 0.16015625, "66207": 0.267578125, "100": 0.0247039794921875, "9433": 0.12902832031... |
1332250 | The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima | Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the ... | {"2646": 0.171630859375, "1651": 0.19921875, "10299": 0.2802734375, "7": 0.06109619140625, "135131": 0.1856689453125, "1081": 0.188720703125, "988": 0.1187744140625, "136": 0.05560302734375, "8877": 0.09881591796875, "44116": 0.1279296875, "8781": 0.1351318359375, "12840": 0.1011962890625, "1687": 0.14453125, "14361": ... |
1333643 | Genetic and Functional Diversification of Small RNA Pathways in Plants | Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and short interfering RNA (siRNA). They collectively function as sequence-specific guides to silence or regulate genes, transposons, and viruses and to modify chromatin and genome structure. For... | {"19335": 0.1688232421875, "8969": 0.1328125, "120087": 0.111572265625, "1175": 0.1275634765625, "1153": 0.2039794921875, "1410": 0.16552734375, "1636": 0.097412109375, "27489": 0.165283203125, "19336": 0.230712890625, "125499": 0.3046875, "49711": 0.1513671875, "70838": 0.0946044921875, "2631": 0.006473541259765625, "... |
1336292 | Immunosuppressant FTY720 inhibits thymocyte emigration. | One major role of the thymus is to provide the peripheral immune system with mature T cells, but the mechanisms involving the cellular export are not fully understood. In this study, we examined the ability of a novel immunosuppressive reagent, FTY720, to inhibit T cell export from the thymus. Daily administration of F... | {"6561": 0.032196044921875, "13036": 0.09588623046875, "31486": 0.1524658203125, "111": 0.060516357421875, "70": 0.0214080810546875, "96055": 0.2362060546875, "2647": 0.260009765625, "83": 0.033355712890625, "47": 0.0213470458984375, "22691": 0.116943359375, "117": 0.05157470703125, "14": 0.0266876220703125, "94266": 0... |
1338283 | Validating a conceptual model for an inter-professional approach to shared decision making: a mixed methods study | RATIONALE, AIMS AND OBJECTIVES Following increased interest in having inter-professional (IP) health care teams engage patients in decision making, we developed a conceptual model for an IP approach to shared decision making (SDM) in primary care. We assessed the validity of the model with stakeholders in Canada. METHO... | {"627": 0.09454345703125, "84780": 0.13330078125, "29644": 0.05853271484375, "4": 0.044769287109375, "38730": 0.159912109375, "13439": 0.154052734375, "48762": 0.08795166015625, "35988": 0.1314697265625, "15301": 0.137939453125, "441": 0.07647705078125, "169813": 0.054718017578125, "77168": 0.00543975830078125, "124735... |
1344498 | Glutaminolysis activates Rag-mTORC1 signaling. | Amino acids control cell growth via activation of the highly conserved kinase TORC1. Glutamine is a particularly important amino acid in cell growth control and metabolism. However, the role of glutamine in TORC1 activation remains poorly defined. Glutamine is metabolized through glutaminolysis to produce α-ketoglutara... | {"21172": 0.173583984375, "31": 0.109619140625, "43840": 0.1634521484375, "6226": 0.2469482421875, "38750": 0.208740234375, "75678": 0.218994140625, "1829": 0.05670166015625, "34704": 0.193115234375, "103210": 0.06634521484375, "118684": 0.12188720703125, "24222": 0.160888671875, "184": 0.1373291015625, "9926": 0.18151... |
1346695 | microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. | Notch plays a critical role in the transition from proliferation to differentiation in the epidermis and corneal epithelium. Furthermore, aberrant Notch signaling is a feature of diseases like psoriasis, eczema, nonmelanoma skin cancer, and melanoma where differentiation and proliferation are impaired. Whereas much is ... | {"11205": 0.259765625, "206": 0.26953125, "11301": 0.08746337890625, "130306": 0.129638671875, "31486": 0.1346435546875, "149307": 0.14697265625, "1295": 0.083984375, "215447": 0.1629638671875, "1363": 0.00970458984375, "47": 0.073486328125, "99710": 0.2127685546875, "2320": 0.009674072265625, "70": 0.00943756103515625... |
1349033 | Advantages of larval control for African malaria vectors: Low mobility and behavioural responsiveness of immature mosquito stages allow high effective coverage | Based on sensitivity analysis of the MacDonald-Ross model, it has long been argued that the best way to reduce malaria transmission is to target adult female mosquitoes with insecticides that can reduce the longevity and human-feeding frequency of vectors. However, these analyses have ignored a fundamental biological d... | {"176302": 0.182861328125, "2481": 0.017547607421875, "114137": 0.1287841796875, "4727": 0.0430908203125, "217258": 0.1951904296875, "9": 0.01381683349609375, "108278": 0.1605224609375, "7": 0.050323486328125, "3299": 0.2115478515625, "4989": 0.0421142578125, "106926": 0.046783447265625, "2965": 0.11956787109375, "3917... |
1354567 | The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center | In Arabidopsis thaliana, small interfering RNAs (siRNAs) direct cytosine methylation at endogenous DNA repeats in a pathway involving two forms of nuclear RNA polymerase IV (Pol IVa and Pol IVb), RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), DICER-LIKE 3 (DCL3), ARGONAUTE4 (AGO4), the chromatin remodeler DRD1, and the de novo... | {"360": 0.032958984375, "129674": 0.213623046875, "246": 0.1351318359375, "74988": 0.1932373046875, "3319": 0.15771484375, "97232": 0.2039794921875, "19336": 0.1151123046875, "1940": 0.10125732421875, "2875": 0.1429443359375, "125499": 0.29443359375, "7": 0.051849365234375, "172": 0.13818359375, "8951": 0.147705078125,... |
1358909 | Peripheral arterial disease in the elderly: The Rotterdam Study. | To assess the age- and sex-specific prevalence of peripheral arterial disease (PAD) and intermittent claudication (IC) in an elderly population, we performed a population-based study in 7715 subjects (40% men, 60% women) aged 55 years and over. The presence of PAD and IC was determined by measuring the ankle-arm systol... | {"202120": 0.103515625, "32070": 0.131103515625, "136": 0.104736328125, "1100": 0.19921875, "9": 0.0237884521484375, "159975": 0.1922607421875, "151497": 0.2298583984375, "3956": 0.064453125, "111": 0.036224365234375, "117": 0.10394287109375, "14": 0.0816650390625, "94266": 0.20556640625, "289": 0.022369384765625, "183... |
1360607 | Antioxidants attenuate the plasma cytokine response to exercise in humans. | Exercise increases plasma TNF-alpha, IL-1beta, and IL-6, yet the stimuli and sources of TNF-alpha and IL-1beta remain largely unknown. We tested the role of oxidative stress and the potential contribution of monocytes in this cytokine (especially IL-1beta) response in previously untrained individuals. Six healthy nonat... | {"155534": 0.25732421875, "184": 0.1602783203125, "51312": 0.18994140625, "80796": 0.18798828125, "384": 0.059661865234375, "73493": 0.218017578125, "289": 0.056671142578125, "14612": 0.1734619140625, "30219": 0.12359619140625, "5759": 0.08941650390625, "59865": 0.24462890625, "4": 0.00885009765625, "13545": 0.18090820... |
1365188 | Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice. | Several data suggest that fermentable dietary fiber could play a role in the control of obesity and associated metabolic disorders. The aim of this study was to investigate the putative role of short chain fructo-oligosaccharide (OFS) - a non-digestible oligosaccharide - in mice fed a standard diet and in mice fed two ... | {"48752": 0.0301361083984375, "289": 0.02386474609375, "2053": 0.087646484375, "42459": 0.05743408203125, "88487": 0.271728515625, "2886": 0.1593017578125, "25969": 0.205810546875, "1294": 0.10797119140625, "109197": 0.265625, "5809": 0.09332275390625, "11301": 0.1104736328125, "31486": 0.1593017578125, "23": 0.0239105... |
1371440 | Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. | Accurate chromosome segregation requires carefully regulated interactions between kinetochores and microtubules, but how plasticity is achieved to correct diverse attachment defects remains unclear. Here we demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinet... | {"29899": 0.07196044921875, "3168": 0.16162109375, "17656": 0.043914794921875, "31": 0.047119140625, "840": 0.12237548828125, "13450": 0.088623046875, "190407": 0.284912109375, "1363": 0.0648193359375, "144570": 0.07818603515625, "197918": 0.05511474609375, "15913": 0.15283203125, "3674": 0.004314422607421875, "182809"... |
1373287 | Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia. | 6-Mercaptopurine (6MP) and methotrexate are the backbone of continuation therapy for childhood acute lymphoblastic leukemia (ALL). In studies of oral 6MP and methotrexate, indices of chronic systemic exposure to active metabolites of these agents, namely, red blood cell (RBC) concentrations of methotrexate polyglutamat... | {"13007": 0.1279296875, "30248": 0.062347412109375, "15644": 0.11810302734375, "188": 0.08184814453125, "51166": 0.17431640625, "86": 0.0938720703125, "16156": 0.0946044921875, "9088": 0.1873779296875, "136": 0.057373046875, "435": 0.1488037109375, "497": 0.1575927734375, "2921": 0.203369140625, "3798": 0.1893310546875... |
1379127 | Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. | Tumor metastasis is the primary cause of death of cancer patients. Understanding the molecular mechanisms underlying tumor metastasis will provide potential drug targets. We report here that Orai1 and STIM1, both of which are involved in store-operated calcium entry, are essential for breast tumor cell migration in vit... | {"1371": 0.168212890625, "4514": 0.14599609375, "435": 0.1785888671875, "6131": 0.21875, "6023": 0.1407470703125, "83": 0.056610107421875, "70": 0.0189208984375, "158978": 0.1392822265625, "22304": 0.151123046875, "111": 0.0305938720703125, "47219": 0.154052734375, "27968": 0.1806640625, "60264": 0.1285400390625, "9626... |
1381673 | Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States | The identity and behavior of mouse spermatogenic stem cells have been a long-standing focus of interest. In the prevailing "As model," stem cell function is restricted to singly isolated (As) spermatogonia. By examining single-cell dynamics of GFRα1+ stem cells in vivo, we evaluate an alternative hypothesis that, throu... | {"182324": 0.2021484375, "136": 0.002849578857421875, "123166": 0.166259765625, "114669": 0.23583984375, "52547": 0.22021484375, "188": 0.0631103515625, "429": 0.111572265625, "6402": 0.04986572265625, "36418": 0.2066650390625, "38750": 0.2034912109375, "2809": 0.0234527587890625, "4989": 0.01338958740234375, "144057":... |
1383826 | Pseudoknots: RNA Structures with Diverse Functions | RNA molecules fulfill a diverse set of biological functions within cells, from the transfer of genetic information from DNA to protein, to enzymatic catalysis. Reflecting this range of roles, simple linear strings of RNA—made up of uracil, guanine, cytosine, and adenine—form a variety of complex three-dimensional struc... | {"6": 0.048309326171875, "125499": 0.340087890625, "49711": 0.213134765625, "70838": 0.2125244140625, "211394": 0.22900390625, "10": 0.066650390625, "9789": 0.22607421875, "5423": 0.112548828125, "111": 0.043487548828125, "333": 0.10662841796875, "109622": 0.11492919921875, "32354": 0.2236328125, "7": 0.07354736328125,... |
1386103 | An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection | Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries. The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T cell-mediated immunity plays an important role in resistance. The lym... | {"1371": 0.1751708984375, "1297": 0.19287109375, "42779": 0.2449951171875, "164": 0.216796875, "10": 0.0155792236328125, "13036": 0.12396240234375, "16227": 0.1951904296875, "2967": 0.21875, "23": 0.02484130859375, "168698": 0.1927490234375, "76726": 0.1180419921875, "456": 0.034332275390625, "195": 0.01447296142578125... |
1387104 | Malignancies, prothrombotic mutations, and the risk of venous thrombosis. | CONTEXT Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life. OBJECTIVE To identify individuals with cancer with an increased thrombotic risk, evaluating different tumor sites, the presence of distant metastases, and carrier status of proth... | {"14452": 0.031036376953125, "122691": 0.1202392578125, "618": 0.00753021240234375, "10146": 0.2283935546875, "10821": 0.1595458984375, "42294": 0.2000732421875, "7567": 0.19677734375, "6023": 0.1690673828125, "83": 0.033843994140625, "10": 0.036712646484375, "39210": 0.11676025390625, "51455": 0.163330078125, "1363": ... |
1387654 | The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. | Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely unknown. Here we address this issue using a dextran sodium sulfate (DSS)-induced colonic regeneration model. We find that regenerating crypts express elevated Yes-ass... | {"106073": 0.0255126953125, "34754": 0.12445068359375, "31486": 0.10235595703125, "45644": 0.1663818359375, "771": 0.22802734375, "26073": 0.1514892578125, "214": 0.06207275390625, "7484": 0.1793212890625, "13267": 0.12274169921875, "6226": 0.1717529296875, "77947": 0.077392578125, "3642": 0.039093017578125, "903": 0.0... |
1388704 | The essence of SNPs. | Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation, distinguished from rare variations by a requirement for the least abundant allele to have a frequency of 1% or more. A wide range of genetics disciplines stand to benefit greatly from the study and use of SNPs. The recent surge of interest... | {"43609": 0.2322998046875, "241454": 0.193115234375, "118": 0.1739501953125, "112": 0.1396484375, "35874": 0.2310791015625, "178851": 0.289794921875, "8780": 0.1943359375, "7": 0.25830078125, "15": 0.0191497802734375, "294": 0.190185546875, "28814": 0.346923828125, "16": 0.0305328369140625, "621": 0.164794921875, "142"... |
1389264 | Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases | Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases (BCBM), and their use for the identification of targeted combination therapies. Combined inhibit... | {"6163": 0.1636962890625, "73": 0.07861328125, "109156": 0.194091796875, "1073": 0.1595458984375, "90": 0.051177978515625, "33636": 0.068359375, "158036": 0.11895751953125, "56465": 0.11199951171875, "66801": 0.15380859375, "85689": 0.11114501953125, "214": 0.018341064453125, "44714": 0.2191162109375, "18504": 0.174804... |
1391126 | Activation of Frontal Neocortical Areas by Vocal Production in Marmosets | Primates often rely on vocal communication to mediate social interactions. Although much is known about the acoustic structure of primate vocalizations and the social context in which they are usually uttered, our knowledge about the neocortical control of audio-vocal interactions in primates is still incipient, being ... | {"19012": 0.215087890625, "1636": 0.1492919921875, "27983": 0.0718994140625, "456": 0.04205322265625, "538": 0.07977294921875, "98": 0.009124755859375, "108171": 0.277587890625, "36398": 0.2149658203125, "47": 0.0074310302734375, "2450": 0.141845703125, "67": 0.10321044921875, "2265": 0.146240234375, "182809": 0.170532... |
1398021 | Familial hiatal hernia in a large five generation family confirming true autosomal dominant inheritance. | BACKGROUND Familial hiatal hernia has only rarely been documented. AIMS To describe the pattern of inheritance of familial hiatal hernia within an affected family. SUBJECTS Thirty eight members of a family pedigree across five generations. METHODS All family members were interviewed and investigated by barium meal for ... | {"8678": 0.0860595703125, "20572": 0.051483154296875, "136498": 0.06732177734375, "72981": 0.2203369140625, "141": 0.10675048828125, "1274": 0.18798828125, "11": 0.10601806640625, "1803": 0.17333984375, "604": 0.2509765625, "1174": 0.2218017578125, "1556": 0.025665283203125, "4734": 0.08111572265625, "41207": 0.1630859... |
1410197 | An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold | Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large portions of the brain. Despite intense experimental research in this field, the earlier cellular events that initiate and sustain a focal seizure are still not we... | {"503": 0.122314453125, "1418": 0.2135009765625, "30891": 0.18603515625, "23": 0.03973388671875, "89716": 0.283203125, "201296": 0.252197265625, "90": 0.1131591796875, "205027": 0.2286376953125, "390": 0.0316162109375, "103210": 0.08868408203125, "200470": 0.1826171875, "10821": 0.01666259765625, "184940": 0.1948242187... |
1412089 | Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities. | BACKGROUND Traditional T2 weighted MR imaging results are non-specific for the extent of underlying white matter structural abnormalities present in late life depression (LLD). Diffusion tensor imaging provides a unique opportunity to investigate the extent and nature of structural injury, but has been limited by exami... | {"8678": 0.09259033203125, "20572": 0.061309814453125, "136498": 0.1148681640625, "97299": 0.09259033203125, "384": 0.125244140625, "304": 0.1807861328125, "57888": 0.20849609375, "297": 0.024993896484375, "69436": 0.1417236328125, "86898": 0.2012939453125, "177": 0.0247650146484375, "50339": 0.0928955078125, "621": 0.... |
1428830 | The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C. | Atypical antipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes. However, the mechanisms underlying these drug-induced metabolic perturbations remain poorly understood. Here, we used an experimental model that reproduces olanzapine-induced hyperphagia and obesity in female C57BL/6 mice... | {"62": 0.031341552734375, "46280": 0.1300048828125, "2874": 0.103271484375, "51775": 0.11724853515625, "3089": 0.1265869140625, "41637": 0.1297607421875, "1425": 0.1968994140625, "596": 0.197021484375, "80654": 0.2115478515625, "27983": 0.056976318359375, "135989": 0.1551513671875, "218527": 0.121826171875, "57888": 0.... |
1428840 | Case-control study of endogenous steroid hormones and endometrial cancer. | BACKGROUND It has been suggested that identified risk factors for endometrial cancer operate through a single etiologic pathway, i.e., exposure to relatively high levels of unopposed estrogen (estrogen in the absence of progestins). Only a few studies, however, have addressed this issue directly. PURPOSE We assessed th... | {"8678": 0.06390380859375, "20572": 0.040679931640625, "136498": 0.08819580078125, "2809": 0.00569915771484375, "42459": 0.0623779296875, "297": 0.043365478515625, "207487": 0.06573486328125, "10512": 0.21142578125, "120103": 0.1741943359375, "100": 0.006916046142578125, "3564": 0.1810302734375, "58174": 0.22998046875,... |
1447990 | FOXO4 is necessary for neural differentiation of human embryonic stem cells. | Proteostasis is critical for maintaining cell function and proteome stability may play an important role in human embryonic stem cell (hESC) immortality. Notably, hESC populations exhibit a high assembly of active proteasomes, a key node of the proteostasis network. FOXO4, an insulin/IGF-1 responsive transcription fact... | {"1250": 0.1614990234375, "67": 0.2054443359375, "5964": 0.22216796875, "6023": 0.16650390625, "83": 0.06390380859375, "130306": 0.2056884765625, "100": 0.07183837890625, "76104": 0.1627197265625, "214": 0.0047760009765625, "38750": 0.182373046875, "32354": 0.1668701171875, "136": 0.006504058837890625, "13766": 0.25317... |
1449692 | Gestational protein restriction affects trophoblast differentiation. | Whether and how gestational protein restriction (PR) affects placental development and function remain unknown. To test the hypothesis that PR can affect trophoblast differentiation in mid-and late pregnancy, rats were fed a 20% or an isocaloric 6% protein diet from Day 1 to 14 or 18 of pregnancy and effects of PR on t... | {"3642": 0.005672454833984375, "45066": 0.1773681640625, "43315": 0.11871337890625, "21308": 0.2340087890625, "185190": 0.278076171875, "17255": 0.243408203125, "52490": 0.1759033203125, "3687": 0.1322021484375, "19": 0.0751953125, "1803": 0.09271240234375, "34754": 0.142822265625, "136": 0.006183624267578125, "32354":... |
1454773 | In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. | The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting bystander tissue damage and preventing the development of autoimmunity during inflammatory responses. PD-1 is expressed by activated T cells and downmodulates T-cell effector functions upon binding to its ligands, PD-L1 and PD-L2, on a... | {"26693": 0.1959228515625, "71": 0.04266357421875, "47219": 0.2352294921875, "5759": 0.24365234375, "34427": 0.2052001953125, "110218": 0.2364501953125, "137376": 0.260986328125, "21265": 0.1112060546875, "237": 0.052947998046875, "43766": 0.15478515625, "60920": 0.137451171875, "12765": 0.1650390625, "38496": 0.193725... |
1456068 | Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study | BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chinese ... | {"8678": 0.07745361328125, "20572": 0.047607421875, "136498": 0.0927734375, "106073": 0.0259246826171875, "194785": 0.20751953125, "200166": 0.2076416015625, "218527": 0.1199951171875, "57913": 0.1727294921875, "23417": 0.09197998046875, "214": 0.034576416015625, "150009": 0.1588134765625, "2481": 0.10614013671875, "4"... |
1469751 | Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy | Currently, major concerns about the safety and efficacy of RNA interference (RNAi)-based bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery systems for osteogenic siRNAs. Here we screened the aptamer CH6 by cell-SELEX, specifically targeting both rat and human osteoblasts, a... | {"114063": 0.03631591796875, "13036": 0.035797119140625, "50509": 0.09759521484375, "81900": 0.168212890625, "136": 0.036865234375, "9129": 0.030303955078125, "22346": 0.09722900390625, "125499": 0.2490234375, "193943": 0.187255859375, "3956": 0.029327392578125, "14": 0.1544189453125, "77007": 0.1195068359375, "32881":... |
1471041 | High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions | Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or HLA-DQ8 (ref. 3). We assessed in a comprehensive and nonbiased manner the IgA anti-... | {"10077": 0.250244140625, "80959": 0.29345703125, "70997": 0.219482421875, "83": 0.07989501953125, "142": 0.032318115234375, "43766": 0.1591796875, "13": 0.0106964111328125, "12333": 0.1513671875, "3674": 0.011749267578125, "171986": 0.1700439453125, "842": 0.11187744140625, "587": 0.132080078125, "2317": 0.05038452148... |
1472815 | Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study. | OBJECTIVE The purpose of our study was to investigate alterations of white matter integrity in adults with major depressive disorder (MDD) using magnetic resonance imaging (MRI). METHODS We performed diffusion tensor imaging with a 3T MRI scanner on 45 patients with major depression and 45 healthy controls matched for ... | {"35988": 0.11724853515625, "15301": 0.14404296875, "441": 0.08770751953125, "169813": 0.047027587890625, "60042": 0.1907958984375, "35187": 0.1182861328125, "509": 0.0069427490234375, "32603": 0.10845947265625, "42068": 0.2027587890625, "5256": 0.0233001708984375, "35011": 0.2325439453125, "26866": 0.255615234375, "91... |
1495563 | [Clinical study on the therapeutic effect of acupuncture in the treatment of post-stroke depression]. | OBJECTIVE To observe the therapeutic effect of "Xingnao Kaiqiao Zhenfa" (Acupuncture Technique for Restoring Consciousness) in the treatment of post-stroke depression. METHODS A total of 256 stroke patients were divided into acupuncture group (n = 180, male 138, female 42) and medication group (n = 76, male 57 and fema... | {"35988": 0.10296630859375, "15301": 0.1395263671875, "441": 0.054840087890625, "169813": 0.01155853271484375, "139999": 0.11859130859375, "6": 0.019805908203125, "126472": 0.1854248046875, "1771": 0.0369873046875, "21543": 0.1822509765625, "44": 0.00984954833984375, "1542": 0.0731201171875, "214": 0.1036376953125, "76... |
1499964 | 30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology | NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use ... | {"6": 0.007213592529296875, "73493": 0.26025390625, "9": 0.07708740234375, "4709": 0.1842041015625, "571": 0.2366943359375, "509": 0.048248291015625, "134053": 0.2083740234375, "496": 0.1756591796875, "5369": 0.12042236328125, "6650": 0.09259033203125, "237": 0.07318115234375, "10": 0.0129241943359375, "25545": 0.12744... |
1507222 | Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia. | Weight loss in cancer cachexia is attributable to decreased food intake and/or enhanced energy expenditure. We investigated the roles of the uncoupling proteins (UCPs) UCPI, -2, and -3 in a murine model of cachexia, the MAC16 adenocarcinoma. Weight fell to 24% below that of non-tumor-bearing controls (P < 0.01) 18 days... | {"150533": 0.2666015625, "86669": 0.1712646484375, "23": 0.11151123046875, "27968": 0.23779296875, "82365": 0.2314453125, "30633": 0.258544921875, "150380": 0.10186767578125, "2886": 0.0645751953125, "227204": 0.1441650390625, "15381": 0.1649169921875, "78219": 0.049346923828125, "136": 0.0098114013671875, "156856": 0.... |
1522336 | In vitro Anti-Tumor Effects of Statins on Head and Neck Squamous Cell Carcinoma: A Systematic Review | BACKGROUND Statins are commonly used against arteriosclerotic disease, but recent retrospective analyses have suggested that statins also prevent cancer. The aim of this systematic review is to verify the vitro anti-tumor effects of statins on head and neck squamous cell carcinoma. METHODS Studies were gathered by sear... | {"8678": 0.066650390625, "20572": 0.045501708984375, "136498": 0.09417724609375, "71465": 0.268798828125, "1779": 0.209716796875, "621": 0.0025768280029296875, "39210": 0.0908203125, "538": 0.0008640289306640625, "11814": 0.182861328125, "26548": 0.16455078125, "146027": 0.1075439453125, "11030": 0.056610107421875, "51... |
1522647 | Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation | BACKGROUND Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We hypothesized that circulating cell-free mtDNA levels would be associated with mortality and improve risk pr... | {"8678": 0.080078125, "20572": 0.05023193359375, "136498": 0.0877685546875, "3574": 0.15185546875, "31": 0.0845947265625, "3089": 0.08447265625, "29887": 0.151611328125, "289": 0.0810546875, "27583": 0.2457275390625, "39": 0.131591796875, "18": 0.185302734375, "125903": 0.282470703125, "16": 0.016510009765625, "83": 0.... |
1538080 | Fructosamine Is a Useful Indicator of Hyperglycaemia and Glucose Control in Clinical and Epidemiological Studies – Cross-Sectional and Longitudinal Experience from the AMORIS Cohort | CONTEXT Fructosamine is a glycemic biomarker which may be useful for indication and control of diabetes respectively. OBJECTIVE The objective of the study was to evaluate fructosamine as an indicator of hyperglycaemia and glucose control in subjects with diabetes. DESIGN, SETTING & PATIENTS From the AMORIS cohort, subj... | {"14452": 0.02783203125, "122691": 0.12646484375, "618": 0.0108184814453125, "37527": 0.2142333984375, "128616": 0.2359619140625, "55343": 0.32861328125, "83": 0.10479736328125, "10": 0.04180908203125, "100483": 0.1331787109375, "329": 0.09320068359375, "21068": 0.0643310546875, "3530": 0.1328125, "10015": 0.2111816406... |
1539159 | Lifeact: a versatile marker to visualize F-actin | Live imaging of the actin cytoskeleton is crucial for the study of many fundamental biological processes, but current approaches to visualize actin have several limitations. Here we describe Lifeact, a 17-amino-acid peptide, which stained filamentous actin (F-actin) structures in eukaryotic cells and tissues. Lifeact d... | {"9251": 0.177734375, "86898": 0.19482421875, "177": 0.0794677734375, "27992": 0.2108154296875, "73": 0.212646484375, "19932": 0.08587646484375, "1952": 0.08447265625, "145482": 0.1824951171875, "191": 0.11871337890625, "83": 0.040374755859375, "106157": 0.1549072265625, "100": 0.029083251953125, "35187": 0.09594726562... |
1542437 | Robustness of Random Forest-based gene selection methods | Gene selection is an important part of microarray data analysis because it provides information that can lead to a better mechanistic understanding of an investigated phenomenon. At the same time, gene selection is very difficult because of the noisy nature of microarray data. As a consequence, gene selection is often ... | {"46980": 0.26904296875, "132216": 0.271728515625, "83": 0.06451416015625, "142": 0.0241851806640625, "5526": 0.1202392578125, "2831": 0.0589599609375, "11948": 0.1201171875, "19305": 0.15380859375, "53": 0.0897216796875, "2053": 0.14990234375, "114137": 0.17431640625, "6637": 0.0240936279296875, "442": 0.0149765014648... |
1544804 | Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA | A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genome. A novel short-rea... | {"158978": 0.154296875, "82761": 0.1650390625, "11737": 0.202880859375, "48281": 0.1829833984375, "1363": 0.05047607421875, "40": 0.12408447265625, "944": 0.178466796875, "60636": 0.1458740234375, "114137": 0.2393798828125, "83": 0.06341552734375, "47": 0.0306549072265625, "143420": 0.223876953125, "16610": 0.188354492... |
1546650 | Functional elements within the dynein microtubule-binding domain | Dynein interacts with microtubules through an ATP-sensitive linkage mapped to a structurally complex region of the heavy chain following the fourth P-loop motif. Virtually nothing is known regarding how binding affinity is achieved and modulated during ATP hydrolysis. We have performed a detailed dissection of the micr... | {"9865": 0.20751953125, "86": 0.2049560546875, "73": 0.25244140625, "78974": 0.2108154296875, "678": 0.08563232421875, "11948": 0.16015625, "46656": 0.1953125, "60291": 0.1259765625, "8305": 0.023529052734375, "127216": 0.2120361328125, "176302": 0.198974609375, "3126": 0.11517333984375, "291": 0.07476806640625, "11899... |
1550937 | The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells | Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanisms regulating these responses are unknown. Here, we report that deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum pr... | {"18118": 0.088623046875, "39": 0.1317138671875, "22014": 0.1451416015625, "2408": 0.1444091796875, "1636": 0.1256103515625, "22691": 0.09326171875, "24087": 0.1513671875, "57553": 0.184326171875, "7": 0.0011034011840820312, "26548": 0.1478271484375, "60875": 0.069580078125, "62976": 0.1571044921875, "678": 0.006416320... |
1554348 | Effect of hyperosmolality on alkaline phosphatase and stress-response protein 27 of MCF-7 breast cancer cells | MCF-7, a continuous cell line derived from a human breast carcinoma, exhibits very low alkaline phosphatase (ALP) activity. The enzyme is heat-stable and is inhibited by L-phenylalanine and L-phenylalanylgly-cylglycine, but not by L-homoarginine, 1-bromotetramisole, or levamisole. These data indicate that MCF-7 produce... | {"276": 0.0982666015625, "84683": 0.265380859375, "16709": 0.2496337890625, "62005": 0.14111328125, "223": 0.00464630126953125, "38750": 0.159423828125, "13315": 0.1636962890625, "16406": 0.068603515625, "1295": 0.01363372802734375, "14135": 0.08770751953125, "57262": 0.1767578125, "2258": 0.0650634765625, "44924": 0.1... |
1568684 | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. | The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in in... | {"33946": 0.137451171875, "119455": 0.22216796875, "20655": 0.1400146484375, "78381": 0.1619873046875, "108055": 0.2041015625, "13": 0.05670166015625, "75999": 0.260986328125, "237": 0.034454345703125, "30388": 0.2230224609375, "30641": 0.1561279296875, "93447": 0.1812744140625, "1771": 0.0255279541015625, "70997": 0.1... |
1569031 | RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA | The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replication. Misincorporation is limited by the selectivity of DNA replicases. We show that accumulation of ribonucleoside monophospha... | {"165045": 0.1610107421875, "182324": 0.2271728515625, "136": 0.0364990234375, "9114": 0.1436767578125, "2481": 0.07781982421875, "111": 0.017822265625, "8584": 0.19384765625, "13": 0.11572265625, "66801": 0.1387939453125, "71": 0.0175018310546875, "70": 0.0180816650390625, "49504": 0.1663818359375, "1363": 0.016952514... |
1574014 | Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74. | Open reading frame 74 (ORF74) encoded by human herpesvirus 8 is a highly constitutively active seven transmembrane (7TM) receptor stimulated by angiogenic chemokines, e.g. growth-related oncogene-alpha, and inhibited by angiostatic chemokines e.g. interferon-gamma-inducible protein. Transgenic mice expressing ORF74 und... | {"13527": 0.2008056640625, "16454": 0.19677734375, "123789": 0.2318115234375, "15124": 0.302490234375, "24638": 0.1746826171875, "919": 0.1719970703125, "88151": 0.308837890625, "22": 0.0814208984375, "40899": 0.1939697265625, "14135": 0.10748291015625, "150381": 0.2200927734375, "76912": 0.1966552734375, "382": 0.1978... |
1576955 | An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. | Mutations in daf-2 and age-1 cause a dramatic increase in longevity as well as developmental arrest at the dauer diapause stage in Caenorhabditis elegans. daf-2 and age-1 encode components of an insulin-like signaling pathway. Both daf-2 and age-1 act at a similar point in the genetic epistasis pathway for dauer arrest... | {"118756": 0.2255859375, "5256": 0.074462890625, "48": 0.1051025390625, "420": 0.2193603515625, "5428": 0.2152099609375, "136": 0.07354736328125, "32070": 0.14208984375, "5759": 0.18212890625, "22304": 0.101318359375, "155034": 0.11474609375, "51312": 0.1368408203125, "23": 0.0143585205078125, "48360": 0.1336669921875,... |
1583041 | Estimating prion concentration in fluids and tissues by quantitative PMCA | Prions, the proteinaceous infectious agent responsible for prion diseases, can be detected with high sensitivity by protein misfolding cyclic amplification (PMCA) technology. Here we describe a quantitative PMCA procedure to calculate the concentration of very low levels of prions in biological samples. Using this proc... | {"2319": 0.26025390625, "5245": 0.24951171875, "21308": 0.2479248046875, "8509": 0.0899658203125, "75622": 0.151611328125, "14": 0.051422119140625, "23882": 0.1875, "102778": 0.2130126953125, "100": 0.0169219970703125, "494": 0.2413330078125, "191": 0.241943359375, "70997": 0.2015380859375, "7": 0.0411376953125, "831":... |
1583134 | Positional cloning of the APECED gene | Autoimmune polyglandular syndrome type I (APS 1, also called APECED) is an autosomal-recessive disorder that maps to human chromosome 21q22.3 between markers D21S49 and D21S171 by linkage studies. We have isolated a novel gene from this region, AIRE (autoimmune regulator), which encodes a protein containing motifs sugg... | {"4396": 0.190673828125, "464": 0.1517333984375, "561": 0.1854248046875, "86": 0.04180908203125, "35874": 0.208984375, "177": 0.10467529296875, "1760": 0.149658203125, "35975": 0.1768798828125, "194923": 0.2073974609375, "10644": 0.19482421875, "87": 0.18017578125, "284": 0.1419677734375, "9059": 0.265380859375, "106":... |
1590744 | AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System | The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2 decades, it has become apparent that AMPK regulates several other cellular functions and has specific roles in ... | {"581": 0.036834716796875, "81218": 0.308349609375, "9": 0.0277557373046875, "111438": 0.1949462890625, "3674": 0.0291290283203125, "21308": 0.222412109375, "24222": 0.2220458984375, "184": 0.1517333984375, "605": 0.29345703125, "83": 0.08746337890625, "10": 0.06243896484375, "22799": 0.16845703125, "144314": 0.2731933... |
1595617 | Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity. | Genome endoreduplication during mammalian development is a rare event for which the mechanism is unknown. It first appears when fibroblast growth factor 4 (FGF4) deprivation induces differentiation of trophoblast stem (TS) cells into the nonproliferating trophoblast giant (TG) cells required for embryo implantation. He... | {"52597": 0.1444091796875, "13": 0.0009479522705078125, "22": 0.1339111328125, "1846": 0.2098388671875, "15246": 0.2138671875, "182867": 0.2257080078125, "20271": 0.12646484375, "21968": 0.1468505859375, "38820": 0.10870361328125, "34754": 0.1700439453125, "83": 0.01824951171875, "41207": 0.1553955078125, "19732": 0.10... |
1605196 | Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming | Successful generation of induced pluripotent stem cells entails a major metabolic switch from mitochondrial oxidative phosphorylation to glycolysis during the reprogramming process. The mechanism of this metabolic reprogramming, however, remains elusive. Here, our results suggest that an Atg5-independent autophagic pro... | {"144053": 0.1292724609375, "7844": 0.0045166015625, "58093": 0.137939453125, "135989": 0.1580810546875, "69795": 0.185791015625, "114680": 0.2032470703125, "36418": 0.1324462890625, "38750": 0.1588134765625, "46741": 0.0694580078125, "13036": 0.00821685791015625, "93447": 0.206298828125, "1771": 0.060516357421875, "10... |
1605392 | A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function | Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, promoting the immune response to pathogens by activating the transcription factor NFAT. We have previously shown that cells from patients with one form of hereditary severe combined immune deficiency (SCID) synd... | {"8332": 0.1463623046875, "1409": 0.1893310546875, "28029": 0.2232666015625, "2320": 0.0848388671875, "111": 0.01308441162109375, "43766": 0.2113037109375, "13": 0.009857177734375, "38750": 0.21044921875, "185553": 0.1676025390625, "2041": 0.1746826171875, "304": 0.1846923828125, "1328": 0.2349853515625, "42805": 0.208... |
1606628 | Estimates of global prevalence of childhood underweight in 1990 and 2015. | CONTEXT One key target of the United Nations Millennium Development goals is to reduce the prevalence of underweight among children younger than 5 years by half between 1990 and 2015. OBJECTIVE To estimate trends in childhood underweight by geographic regions of the world. DESIGN, SETTING, AND PARTICIPANTS Time series ... | {"14452": 0.025146484375, "122691": 0.12744140625, "6561": 0.032196044921875, "22799": 0.133056640625, "30388": 0.208251953125, "111": 0.02508544921875, "14098": 0.0948486328125, "145704": 0.11407470703125, "241925": 0.19970703125, "55441": 0.1802978515625, "109458": 0.1815185546875, "83": 0.02520751953125, "34390": 0.... |
1616661 | Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. | Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood-brain barrier, whereas blood vessels of other organ... | {"87769": 0.11834716796875, "7484": 0.24658203125, "56566": 0.1597900390625, "98": 0.051727294921875, "59714": 0.181396484375, "53678": 0.1751708984375, "41204": 0.1290283203125, "100": 0.04742431640625, "230044": 0.17236328125, "136": 0.065185546875, "21650": 0.09393310546875, "35066": 0.038177490234375, "1284": 0.025... |
1617327 | Bone progenitor dysfunction induces myelodysplasia and secondary leukemia | Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, b... | {"12021": 0.160888671875, "33": 0.10986328125, "7668": 0.2315673828125, "2749": 0.140625, "38750": 0.22705078125, "7": 0.050048828125, "162466": 0.1993408203125, "89697": 0.1910400390625, "11": 0.1619873046875, "2684": 0.07421875, "3638": 0.12091064453125, "136": 0.0263519287109375, "186470": 0.08929443359375, "108055"... |
1624106 | Generating diploid embryos from Xenopus tropicalis. | A spectacular advantage of Xenopus tropicalis is the ease with which diploid embryos can be generated year round. By the simple administration of human chorionic gonadotropin, an investigator can generate many hundreds of synchronized embryos by in vitro fertilization or thousands of embryos from a mating pair. The abi... | {"62": 0.004535675048828125, "42706": 0.10601806640625, "25667": 0.07415771484375, "92940": 0.2169189453125, "111": 0.0079803466796875, "22742": 0.136474609375, "157": 0.12744140625, "7332": 0.228515625, "143257": 0.2244873046875, "164": 0.121337890625, "83": 0.0200653076171875, "28": 0.033905029296875, "6991": 0.13122... |
1630949 | Oct4-Induced Pluripotency in Adult Neural Stem Cells | The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and human fibroblasts. We previously described direct reprogramming of adult mouse neural stem cells (NSCs) by Oct4 and either Klf4 or c-Myc. NSCs endogenously express Sox2, c-Myc, and Klf4 as well as several intermediate reprog... | {"22759": 0.18994140625, "30334": 0.1326904296875, "59478": 0.182861328125, "120103": 0.238037109375, "33649": 0.2022705078125, "617": 0.2392578125, "1061": 0.10870361328125, "425": 0.10919189453125, "304": 0.1419677734375, "17463": 0.185546875, "501": 0.04473876953125, "9": 0.0087890625, "31852": 0.177001953125, "238"... |
1631583 | Getting started with yeast. | Publisher Summary The yeast Saccharomyces cerevisiae is now recognized as a model system representing a simple eukaryote whose genome can be easily manipulated. Yeast has only a slightly greater genetic complexity than bacteria and shares many of the technical advantages that permitted rapid progress in the molecular g... | {"193612": 0.1795654296875, "131150": 0.11773681640625, "1294": 0.047943115234375, "581": 0.08087158203125, "2422": 0.277587890625, "4438": 0.2861328125, "80085": 0.1572265625, "9254": 0.2135009765625, "306": 0.173095703125, "53": 0.1497802734375, "5170": 0.12347412109375, "41424": 0.1466064453125, "1824": 0.2069091796... |
1635872 | PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication | Ubiquitin-mediated proteolysis of the replication licensing factor Cdt1 (Cdc10-dependent transcript 1) in S phase is a key mechanism that limits DNA replication to a single round per cell cycle in metazoans. In Xenopus egg extracts, Cdt1 is destroyed on chromatin during DNA replication. Here, we report that replication... | {"125895": 0.12298583984375, "3181": 0.1348876953125, "2311": 0.15185546875, "12333": 0.1387939453125, "13766": 0.1844482421875, "929": 0.095458984375, "147852": 0.1466064453125, "456": 0.10064697265625, "182867": 0.2044677734375, "400": 0.03399658203125, "35481": 0.1341552734375, "31461": 0.1611328125, "313": 0.094970... |
1641873 | Meiosis in Drosophila: seeing is believing. | Recently many exciting advances have been achieved in our understanding of Drosophila meiosis due to combined cytological and genetic approaches. New techniques have permitted the characterization of chromosome position and spindle formation in female meiosis I. The proteins encoded by the nod and ncd genes, two genes ... | {"169549": 0.060211181640625, "5941": 0.045745849609375, "136950": 0.0968017578125, "129745": 0.189208984375, "69307": 0.12359619140625, "2446": 0.0007395744323730469, "100094": 0.1663818359375, "1773": 0.0958251953125, "6781": 0.161865234375, "66847": 0.268310546875, "11": 0.1142578125, "17150": 0.228515625, "6023": 0... |
1642727 | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. | CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. OBJECTIVE To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. DESIGN AND SETTING Randomized controlled tri... | {"14452": 0.01183319091796875, "122691": 0.09942626953125, "52455": 0.0230865478515625, "150556": 0.1475830078125, "289": 0.029571533203125, "96335": 0.051361083984375, "765": 0.0299530029296875, "127887": 0.00139617919921875, "72761": 0.250732421875, "103488": 0.2208251953125, "34390": 0.206298828125, "7": 0.080444335... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.