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RE
ADE_corpus_sample_15000
train
Eruptive epidermoid cysts resulting from treatment with imiquimod .
adverse effect: Eruptive epidermoid cysts -> imiquimod
adverse effect
{"relations": [{"head": "Eruptive epidermoid cysts", "relation": "adverse effect", "tail": "imiquimod"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin .
adverse effect: Bronchiolitis obliterans organising pneumonia -> nitrofurantoin
adverse effect
{"relations": [{"head": "Bronchiolitis obliterans organising pneumonia", "relation": "adverse effect", "tail": "nitrofurantoin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode .
adverse effect: overanticoagulation -> acenocoumarol
adverse effect
{"relations": [{"head": "overanticoagulation", "relation": "adverse effect", "tail": "acenocoumarol"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Hypersensitivity to aspirin can be manifested as acute asthma , urticaria and/or angioedema , or a systemic anaphylactoid reaction .
adverse effect: urticaria -> aspirin | adverse effect: systemic anaphylactoid reaction -> aspirin | adverse effect: angioedema -> aspirin
adverse effect
{"relations": [{"head": "angioedema", "relation": "adverse effect", "tail": "aspirin"}, {"head": "systemic anaphylactoid reaction", "relation": "adverse effect", "tail": "aspirin"}, {"head": "urticaria", "relation": "adverse effect", "tail": "aspirin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin .
adverse effect: severe hypersensitivity -> carboplatin
adverse effect
{"relations": [{"head": "severe hypersensitivity", "relation": "adverse effect", "tail": "carboplatin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Although the data indicate an immune - complex cause for gold - salt nephropathy , the incident antigen ( or antigens ) and mechanism of action remain unidentified .
adverse effect: nephropathy -> gold - salt
adverse effect
{"relations": [{"head": "nephropathy", "relation": "adverse effect", "tail": "gold - salt"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Phenylpropanolamine ( PPA ) recently has been publicly implicated as a cause of stroke and other neurologic events .
adverse effect: stroke -> PPA | adverse effect: neurologic events -> PPA | adverse effect: stroke -> Phenylpropanolamine | adverse effect: neurologic events -> Phenylpropanolamine
adverse effect
{"relations": [{"head": "neurologic events", "relation": "adverse effect", "tail": "Phenylpropanolamine"}, {"head": "neurologic events", "relation": "adverse effect", "tail": "PPA"}, {"head": "stroke", "relation": "adverse effect", "tail": "Phenylpropanolamine"}, {"head": "stroke", "relation": "adverse effect", "tail": "PPA"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Multiple complications of propylthiouracil treatment : granulocytopenia , eosinophilia , skin reaction and hepatitis with lymphocyte sensitization .
adverse effect: skin reaction -> propylthiouracil | adverse effect: lymphocyte sensitization -> propylthiouracil | adverse effect: eosinophilia -> propylthiouracil | adverse effect: granulocytopenia -> propylthiouracil | adverse effect: hepatitis -> propylthiouracil
adverse effect
{"relations": [{"head": "eosinophilia", "relation": "adverse effect", "tail": "propylthiouracil"}, {"head": "granulocytopenia", "relation": "adverse effect", "tail": "propylthiouracil"}, {"head": "hepatitis", "relation": "adverse effect", "tail": "propylthiouracil"}, {"head": "lymphocyte sensitization", "relation": "adverse effect", "tail": "propylthiouracil"}, {"head": "skin reaction", "relation": "adverse effect", "tail": "propylthiouracil"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Hence , hyperthyroidism induced by IFN - alpha could correspond to the first phase of silent thyroiditis , to Graves ' disease or to the succession of both .
adverse effect: hyperthyroidism -> IFN - alpha
adverse effect
{"relations": [{"head": "hyperthyroidism", "relation": "adverse effect", "tail": "IFN - alpha"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue .
adverse effect: hypersensitivity -> carboplatin
adverse effect
{"relations": [{"head": "hypersensitivity", "relation": "adverse effect", "tail": "carboplatin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Thus , an immunological mechanism might be involved in the mechanism of pirmenol - induced QT prolongation and T wave inversion on the electrocardiogram .
adverse effect: QT prolongation -> pirmenol | adverse effect: T wave inversion -> pirmenol
adverse effect
{"relations": [{"head": "QT prolongation", "relation": "adverse effect", "tail": "pirmenol"}, {"head": "T wave inversion", "relation": "adverse effect", "tail": "pirmenol"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Magnesium tocolysis as the cause of urinary calculus during pregnancy .
adverse effect: urinary calculus -> Magnesium
adverse effect
{"relations": [{"head": "urinary calculus", "relation": "adverse effect", "tail": "Magnesium"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis .
adverse effect: tuberculosis -> Efalizumab | adverse effect: tuberculosis -> Etanercept
adverse effect
{"relations": [{"head": "tuberculosis", "relation": "adverse effect", "tail": "Efalizumab"}, {"head": "tuberculosis", "relation": "adverse effect", "tail": "Etanercept"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
OBJECTIVES : The authors described a case of Hashimoto 's disease during interferon - alpha ( IFN - alpha ) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease .
adverse effect: Hashimoto 's disease -> interferon - alpha | adverse effect: Hashimoto 's disease -> IFN - alpha
adverse effect
{"relations": [{"head": "Hashimoto 's disease", "relation": "adverse effect", "tail": "IFN - alpha"}, {"head": "Hashimoto 's disease", "relation": "adverse effect", "tail": "interferon - alpha"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Hepatic damage after danazol treatment .
adverse effect: Hepatic damage -> danazol
adverse effect
{"relations": [{"head": "Hepatic damage", "relation": "adverse effect", "tail": "danazol"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Niacin maculopathy .
adverse effect: maculopathy -> Niacin
adverse effect
{"relations": [{"head": "maculopathy", "relation": "adverse effect", "tail": "Niacin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Angioedema and dysphagia caused by contact allergy to inhaled budesonide .
adverse effect: dysphagia -> budesonide | adverse effect: Angioedema -> budesonide
adverse effect
{"relations": [{"head": "Angioedema", "relation": "adverse effect", "tail": "budesonide"}, {"head": "dysphagia", "relation": "adverse effect", "tail": "budesonide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
OBSERVATIONS : A 48-year - old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection .
adverse effect: disfiguring facial edema -> ribavirin | adverse effect: disfiguring facial edema -> peginterferon alfa-2a
adverse effect
{"relations": [{"head": "disfiguring facial edema", "relation": "adverse effect", "tail": "peginterferon alfa-2a"}, {"head": "disfiguring facial edema", "relation": "adverse effect", "tail": "ribavirin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement .
adverse effect: right ventricular failure -> protamine | adverse effect: pulmonary vasoconstriction -> protamine
adverse effect
{"relations": [{"head": "pulmonary vasoconstriction", "relation": "adverse effect", "tail": "protamine"}, {"head": "right ventricular failure", "relation": "adverse effect", "tail": "protamine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Fatal pulmonary fibrosis associated with BCNU : the relative role of platelet - derived growth factor - B , insulin - like growth factor I , transforming growth factor - beta1 and cyclooxygenase-2 .
adverse effect: Fatal pulmonary fibrosis -> BCNU
adverse effect
{"relations": [{"head": "Fatal pulmonary fibrosis", "relation": "adverse effect", "tail": "BCNU"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Syncope in a 65-year - old woman after nitrate ingestion .
adverse effect: Syncope -> nitrate
adverse effect
{"relations": [{"head": "Syncope", "relation": "adverse effect", "tail": "nitrate"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
A 57-year - old man developed morphea while taking bromocriptine .
adverse effect: morphea -> bromocriptine
adverse effect
{"relations": [{"head": "morphea", "relation": "adverse effect", "tail": "bromocriptine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses .
adverse effect: cardiac arrhythmias -> amphotericin B | adverse effect: mortality -> amphotericin B
adverse effect
{"relations": [{"head": "cardiac arrhythmias", "relation": "adverse effect", "tail": "amphotericin B"}, {"head": "mortality", "relation": "adverse effect", "tail": "amphotericin B"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Clinicians who manage cachectic patients , particularly those with protracted diarrhoea and/or receiving anti - malarial drugs including mefloquine , should be aware of the risk of severe hypoglycaemia .
adverse effect: severe hypoglycaemia -> mefloquine
adverse effect
{"relations": [{"head": "severe hypoglycaemia", "relation": "adverse effect", "tail": "mefloquine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
MATERIALS AND METHODS : We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin .
adverse effect: primary and secondary perforation of the bladder -> epirubicin
adverse effect
{"relations": [{"head": "primary and secondary perforation of the bladder", "relation": "adverse effect", "tail": "epirubicin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Gold nephropathy : tissue analysis by X - ray fluorescent spectroscopy .
adverse effect: nephropathy -> Gold
adverse effect
{"relations": [{"head": "nephropathy", "relation": "adverse effect", "tail": "Gold"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Triazolam - induced nocturnal bingeing with amnesia .
adverse effect: nocturnal bingeing -> Triazolam | adverse effect: amnesia -> Triazolam
adverse effect
{"relations": [{"head": "amnesia", "relation": "adverse effect", "tail": "Triazolam"}, {"head": "nocturnal bingeing", "relation": "adverse effect", "tail": "Triazolam"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
This case presentation is of a patient who had the clinical appearance of epiglottitis , but actually had an oro - pharyngeal dystonic reaction to prochlorperazine .
adverse effect: epiglottitis -> prochlorperazine | adverse effect: oro - pharyngeal dystonic reaction -> prochlorperazine
adverse effect
{"relations": [{"head": "epiglottitis", "relation": "adverse effect", "tail": "prochlorperazine"}, {"head": "oro - pharyngeal dystonic reaction", "relation": "adverse effect", "tail": "prochlorperazine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The probable proarrhythmic action of amiodarone , although rare , is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy .
adverse effect: proarrhythmic -> amiodarone
adverse effect
{"relations": [{"head": "proarrhythmic", "relation": "adverse effect", "tail": "amiodarone"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Five and one - half years after the diagnosis of myeloma , while in remission on cyclophosphamide therapy , the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma .
adverse effect: abdominal right lower quadrant pain -> cyclophosphamide | adverse effect: cecal lymphoma -> cyclophosphamide
adverse effect
{"relations": [{"head": "abdominal right lower quadrant pain", "relation": "adverse effect", "tail": "cyclophosphamide"}, {"head": "cecal lymphoma", "relation": "adverse effect", "tail": "cyclophosphamide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
OBJECTIVE : To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2 .
adverse effect: cutaneous and hematologic toxicity -> IL-2
adverse effect
{"relations": [{"head": "cutaneous and hematologic toxicity", "relation": "adverse effect", "tail": "IL-2"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Sulfasalazine - induced lupus erythematosus .
adverse effect: lupus erythematosus -> Sulfasalazine
adverse effect
{"relations": [{"head": "lupus erythematosus", "relation": "adverse effect", "tail": "Sulfasalazine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Nephrotic syndrome associated with interferon - beta-1b therapy for multiple sclerosis .
adverse effect: Nephrotic syndrome -> interferon - beta-1b
adverse effect
{"relations": [{"head": "Nephrotic syndrome", "relation": "adverse effect", "tail": "interferon - beta-1b"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium ( Depakote ) , resulting in serum concentrations 10 times greater than the therapeutic range .
adverse effect: symptomatic methemoglobinemia -> divalproex sodium | adverse effect: symptomatic methemoglobinemia -> Depakote
adverse effect
{"relations": [{"head": "symptomatic methemoglobinemia", "relation": "adverse effect", "tail": "Depakote"}, {"head": "symptomatic methemoglobinemia", "relation": "adverse effect", "tail": "divalproex sodium"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
CONCLUSIONS : In our reported case , a local hyperproduction of TNF - alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone .
adverse effect: dedifferentiation of the adipocytes -> insulin | adverse effect: hyperproduction of TNF - alpha -> insulin
adverse effect
{"relations": [{"head": "dedifferentiation of the adipocytes", "relation": "adverse effect", "tail": "insulin"}, {"head": "hyperproduction of TNF - alpha", "relation": "adverse effect", "tail": "insulin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Renal injury due to anastrozole has not been published in the English literature .
adverse effect: Renal injury -> anastrozole
adverse effect
{"relations": [{"head": "Renal injury", "relation": "adverse effect", "tail": "anastrozole"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Sustained - release procainamide - induced reversible granulocytopenia after myocardial infarction .
adverse effect: reversible granulocytopenia -> procainamide
adverse effect
{"relations": [{"head": "reversible granulocytopenia", "relation": "adverse effect", "tail": "procainamide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
During clarithromycin coadministration , four out of the seven patients developed moderate - to - severe toxic symptoms of carbamazepine , such as drowsiness , dizziness , and ataxia , which resolved within 5 days after clarithromycin discontinuation .
adverse effect: dizziness -> clarithromycin | adverse effect: drowsiness -> carbamazepine | adverse effect: toxic symptoms -> clarithromycin | adverse effect: drowsiness -> clarithromycin | adverse effect: ataxia -> clarithromycin | adverse effect: toxic symptoms -> carbamazepine | adverse effect: dizziness -> carbamazepine | adverse effect: ataxia -> carbamazepine
adverse effect
{"relations": [{"head": "ataxia", "relation": "adverse effect", "tail": "carbamazepine"}, {"head": "ataxia", "relation": "adverse effect", "tail": "clarithromycin"}, {"head": "dizziness", "relation": "adverse effect", "tail": "carbamazepine"}, {"head": "dizziness", "relation": "adverse effect", "tail": "clarithromycin"}, {"head": "drowsiness", "relation": "adverse effect", "tail": "carbamazepine"}, {"head": "drowsiness", "relation": "adverse effect", "tail": "clarithromycin"}, {"head": "toxic symptoms", "relation": "adverse effect", "tail": "carbamazepine"}, {"head": "toxic symptoms", "relation": "adverse effect", "tail": "clarithromycin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
However , cyclosporine dependency is associated with the risk of nephrotoxicity .
adverse effect: nephrotoxicity -> cyclosporine
adverse effect
{"relations": [{"head": "nephrotoxicity", "relation": "adverse effect", "tail": "cyclosporine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication .
adverse effect: AZ intoxication -> AZ | adverse effect: acute hemorrhagic gastritis -> AZ
adverse effect
{"relations": [{"head": "acute hemorrhagic gastritis", "relation": "adverse effect", "tail": "AZ"}, {"head": "AZ intoxication", "relation": "adverse effect", "tail": "AZ"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We now report the first known cancer patient who developed life - threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency .
adverse effect: life - threatening complications -> 5-FU
adverse effect
{"relations": [{"head": "life - threatening complications", "relation": "adverse effect", "tail": "5-FU"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy , we conducted a retrospective survey of 25 additional patients with Wilson 's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine .
adverse effect: neurologic disease -> penicillamine | adverse effect: neurologic worsening -> penicillamine
adverse effect
{"relations": [{"head": "neurologic disease", "relation": "adverse effect", "tail": "penicillamine"}, {"head": "neurologic worsening", "relation": "adverse effect", "tail": "penicillamine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Cephalosporins are most likely associated with Vitamin K deficiency .
adverse effect: Vitamin K deficiency -> Cephalosporins
adverse effect
{"relations": [{"head": "Vitamin K deficiency", "relation": "adverse effect", "tail": "Cephalosporins"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Multiple seizures after bupropion overdose in a small child .
adverse effect: Multiple seizures -> bupropion
adverse effect
{"relations": [{"head": "Multiple seizures", "relation": "adverse effect", "tail": "bupropion"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN - beta therapy for the malignant melanoma .
adverse effect: histological abnormalities of the glomerulus -> IFN - beta
adverse effect
{"relations": [{"head": "histological abnormalities of the glomerulus", "relation": "adverse effect", "tail": "IFN - beta"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
BACKGROUND : Reproductive endocrine disorders characterized by menstrual disorders , polycystic ovaries , and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy .
adverse effect: polycystic ovaries -> sodium valproate | adverse effect: Reproductive endocrine disorders -> sodium valproate | adverse effect: menstrual disorders -> sodium valproate | adverse effect: hyperandrogenism -> sodium valproate
adverse effect
{"relations": [{"head": "hyperandrogenism", "relation": "adverse effect", "tail": "sodium valproate"}, {"head": "menstrual disorders", "relation": "adverse effect", "tail": "sodium valproate"}, {"head": "polycystic ovaries", "relation": "adverse effect", "tail": "sodium valproate"}, {"head": "Reproductive endocrine disorders", "relation": "adverse effect", "tail": "sodium valproate"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
However , in order to avoid neuropathic side effects , patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug .
adverse effect: neuropathic side effects -> thalidomide
adverse effect
{"relations": [{"head": "neuropathic side effects", "relation": "adverse effect", "tail": "thalidomide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Conventional and diffusion - weighted MRI findings of methotrexate related sub - acute neurotoxicity .
adverse effect: sub - acute neurotoxicity -> methotrexate
adverse effect
{"relations": [{"head": "sub - acute neurotoxicity", "relation": "adverse effect", "tail": "methotrexate"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus , therefore , in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment .
adverse effect: type 1 diabetes mellitus -> recombinant alpha-2b peginterferon | adverse effect: type 1 diabetes mellitus -> ribavirin
adverse effect
{"relations": [{"head": "type 1 diabetes mellitus", "relation": "adverse effect", "tail": "recombinant alpha-2b peginterferon"}, {"head": "type 1 diabetes mellitus", "relation": "adverse effect", "tail": "ribavirin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non - haemorrhagic hypovolaemia is presented , with a discussion on the management and the use of allergy identification jewellery .
adverse effect: anaphylactoid reaction -> Gelofusine
adverse effect
{"relations": [{"head": "anaphylactoid reaction", "relation": "adverse effect", "tail": "Gelofusine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
SUBSEQUENT COURSE : The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment .
adverse effect: nephrosis -> interferon
adverse effect
{"relations": [{"head": "nephrosis", "relation": "adverse effect", "tail": "interferon"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The association of central diabetes insipidus ( CDI ) with lithium use is rare .
adverse effect: CDI -> lithium | adverse effect: central diabetes insipidus -> lithium
adverse effect
{"relations": [{"head": "CDI", "relation": "adverse effect", "tail": "lithium"}, {"head": "central diabetes insipidus", "relation": "adverse effect", "tail": "lithium"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Apparent central nervous system depression in infants after the use of topical brimonidine .
adverse effect: central nervous system depression -> brimonidine
adverse effect
{"relations": [{"head": "central nervous system depression", "relation": "adverse effect", "tail": "brimonidine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible , and that periodic urine testing in patients receiving pranlukast should be considered .
adverse effect: ATIN -> pranlukast | adverse effect: hypersensitivity reaction -> pranlukast
adverse effect
{"relations": [{"head": "ATIN", "relation": "adverse effect", "tail": "pranlukast"}, {"head": "hypersensitivity reaction", "relation": "adverse effect", "tail": "pranlukast"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Five days after the fourth dose of vincristine , she presented with bilateral ptosis .
adverse effect: bilateral ptosis -> vincristine
adverse effect
{"relations": [{"head": "bilateral ptosis", "relation": "adverse effect", "tail": "vincristine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Clozapine induced polyserositis .
adverse effect: polyserositis -> Clozapine
adverse effect
{"relations": [{"head": "polyserositis", "relation": "adverse effect", "tail": "Clozapine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Four days after the initial injection of 3.6 mg of goserelin acetate , severe dyspnea developed due to worsening pleuritis carcinomatosa , which was considered as a flare - up .
adverse effect: flare - up -> goserelin acetate | adverse effect: severe dyspnea -> goserelin acetate | adverse effect: worsening pleuritis carcinomatosa -> goserelin acetate
adverse effect
{"relations": [{"head": "flare - up", "relation": "adverse effect", "tail": "goserelin acetate"}, {"head": "severe dyspnea", "relation": "adverse effect", "tail": "goserelin acetate"}, {"head": "worsening pleuritis carcinomatosa", "relation": "adverse effect", "tail": "goserelin acetate"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Second , we report a case of neutropenia , which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide .
adverse effect: neutropenia -> olanzapine | adverse effect: neutropenia -> thiazide
adverse effect
{"relations": [{"head": "neutropenia", "relation": "adverse effect", "tail": "olanzapine"}, {"head": "neutropenia", "relation": "adverse effect", "tail": "thiazide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
In two patients with mycosis fungoides , a squamous cell carcinoma developed during therapy with psoralens plus long - wave ultraviolet radiation ( PUVA ) .
adverse effect: squamous cell carcinoma -> psoralens
adverse effect
{"relations": [{"head": "squamous cell carcinoma", "relation": "adverse effect", "tail": "psoralens"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Flurbiprofen - associated acute tubulointerstitial nephritis .
adverse effect: acute tubulointerstitial nephritis -> Flurbiprofen
adverse effect
{"relations": [{"head": "acute tubulointerstitial nephritis", "relation": "adverse effect", "tail": "Flurbiprofen"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The mechanism of anaphylactoid reaction to zomepirac in this case , therefore , remains unclear .
adverse effect: anaphylactoid reaction -> zomepirac
adverse effect
{"relations": [{"head": "anaphylactoid reaction", "relation": "adverse effect", "tail": "zomepirac"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
L - asparaginase - provoked seizures as singular expression of central nervous toxicity .
adverse effect: seizures -> L - asparaginase | adverse effect: central nervous toxicity -> L - asparaginase
adverse effect
{"relations": [{"head": "central nervous toxicity", "relation": "adverse effect", "tail": "L - asparaginase"}, {"head": "seizures", "relation": "adverse effect", "tail": "L - asparaginase"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Possible linkage of amprenavir with intracranial bleeding in an HIV - infected hemophiliac .
adverse effect: intracranial bleeding -> amprenavir
adverse effect
{"relations": [{"head": "intracranial bleeding", "relation": "adverse effect", "tail": "amprenavir"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Within 24 hours of fluid restriction and cessation of desmopressin , her symptoms and hyponatremia resolved .
adverse effect: hyponatremia -> desmopressin
adverse effect
{"relations": [{"head": "hyponatremia", "relation": "adverse effect", "tail": "desmopressin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma .
adverse effect: ulcer -> theophylline
adverse effect
{"relations": [{"head": "ulcer", "relation": "adverse effect", "tail": "theophylline"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
High - dose intravenous mannitol infusion in various clinical settings may result in acute renal failure ( ARF ) .
adverse effect: ARF -> mannitol | adverse effect: acute renal failure -> mannitol
adverse effect
{"relations": [{"head": "acute renal failure", "relation": "adverse effect", "tail": "mannitol"}, {"head": "ARF", "relation": "adverse effect", "tail": "mannitol"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving ' standard ' doses of dexamethasone as part of the antiemetic regimen used in cisplatin - based combination chemotherapy .
adverse effect: bilateral avascular necrosis of the femoral heads -> dexamethasone
adverse effect
{"relations": [{"head": "bilateral avascular necrosis of the femoral heads", "relation": "adverse effect", "tail": "dexamethasone"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
CASE SUMMARY : A 46-year - old African - American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B , then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time .
adverse effect: grand mal seizures -> amphotericin B
adverse effect
{"relations": [{"head": "grand mal seizures", "relation": "adverse effect", "tail": "amphotericin B"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Because psoralens sensitize skin to ultraviolet A light , phototoxic reactions are the most frequent adverse effect of this treatment .
adverse effect: phototoxic reactions -> psoralens
adverse effect
{"relations": [{"head": "phototoxic reactions", "relation": "adverse effect", "tail": "psoralens"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy .
adverse effect: supravenous hyperpigmentation -> CHOP
adverse effect
{"relations": [{"head": "supravenous hyperpigmentation", "relation": "adverse effect", "tail": "CHOP"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The authors present a case study of a mentally healthy man who repeatedly experienced short - lived , obsessional - like suicidal ideas and images after ingestion of the anti - fungal drug ketoconazole .
adverse effect: obsessional - like suicidal ideas and images -> ketoconazole
adverse effect
{"relations": [{"head": "obsessional - like suicidal ideas and images", "relation": "adverse effect", "tail": "ketoconazole"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
After extensive neurological ' work up ' , we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid .
adverse effect: anisocoria -> scopolamine
adverse effect
{"relations": [{"head": "anisocoria", "relation": "adverse effect", "tail": "scopolamine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We assume that rIFN - gamma induced the de novo development of SLE in our patient .
adverse effect: SLE -> rIFN - gamma
adverse effect
{"relations": [{"head": "SLE", "relation": "adverse effect", "tail": "rIFN - gamma"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Atrial fibrillation following methylprednisolone pulse therapy .
adverse effect: Atrial fibrillation -> methylprednisolone
adverse effect
{"relations": [{"head": "Atrial fibrillation", "relation": "adverse effect", "tail": "methylprednisolone"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin .
adverse effect: erythema multiforme -> griseofulvin
adverse effect
{"relations": [{"head": "erythema multiforme", "relation": "adverse effect", "tail": "griseofulvin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
She was receiving phenytoin sodium 300 mg / day ; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia .
adverse effect: leukopenia -> phenytoin sodium | adverse effect: leukopenia -> carbamazepine
adverse effect
{"relations": [{"head": "leukopenia", "relation": "adverse effect", "tail": "carbamazepine"}, {"head": "leukopenia", "relation": "adverse effect", "tail": "phenytoin sodium"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We describe the case of acute hepatitis induced by gliclazide , a second generation sulfonylurea .
adverse effect: acute hepatitis -> gliclazide
adverse effect
{"relations": [{"head": "acute hepatitis", "relation": "adverse effect", "tail": "gliclazide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
OBJECTIVE : To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine .
adverse effect: allergic reactions -> capecitabine
adverse effect
{"relations": [{"head": "allergic reactions", "relation": "adverse effect", "tail": "capecitabine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
A patient with chronic myeloid leukaemia treated with busulphan for 4 - 5 years , developed signs of busulphan toxicity and portal hypertension with ascites , oesophageal varices and jaundice .
adverse effect: portal hypertension -> busulphan | adverse effect: oesophageal varices -> busulphan | adverse effect: jaundice -> busulphan | adverse effect: ascites -> busulphan
adverse effect
{"relations": [{"head": "ascites", "relation": "adverse effect", "tail": "busulphan"}, {"head": "jaundice", "relation": "adverse effect", "tail": "busulphan"}, {"head": "oesophageal varices", "relation": "adverse effect", "tail": "busulphan"}, {"head": "portal hypertension", "relation": "adverse effect", "tail": "busulphan"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Niflumic acid - induced skeletal fluorosis : iatrogenic disease or therapeutic perspective for osteoporosis ?
adverse effect: skeletal fluorosis -> Niflumic acid
adverse effect
{"relations": [{"head": "skeletal fluorosis", "relation": "adverse effect", "tail": "Niflumic acid"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Hyponatraemia developed after rechallenge with controlled release carbamazepine .
adverse effect: Hyponatraemia -> carbamazepine
adverse effect
{"relations": [{"head": "Hyponatraemia", "relation": "adverse effect", "tail": "carbamazepine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea .
adverse effect: CML -> hydroxyurea
adverse effect
{"relations": [{"head": "CML", "relation": "adverse effect", "tail": "hydroxyurea"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril - induced acute renal failure .
adverse effect: acute renal failure -> captopril
adverse effect
{"relations": [{"head": "acute renal failure", "relation": "adverse effect", "tail": "captopril"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Since 1979 , over 30 published case reports have documented the relationship between phenylpropanolamine and stroke .
adverse effect: stroke -> phenylpropanolamine
adverse effect
{"relations": [{"head": "stroke", "relation": "adverse effect", "tail": "phenylpropanolamine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
DISCUSSION : To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept .
adverse effect: tuberculous uveitis -> etanercept
adverse effect
{"relations": [{"head": "tuberculous uveitis", "relation": "adverse effect", "tail": "etanercept"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome , a rare congenital disorder .
adverse effect: interstitial hypoxaemiant pneumonitis -> flecainide
adverse effect
{"relations": [{"head": "interstitial hypoxaemiant pneumonitis", "relation": "adverse effect", "tail": "flecainide"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Methotrexate - induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis : report of five cases and review of the literature .
adverse effect: pneumonitis -> Methotrexate
adverse effect
{"relations": [{"head": "pneumonitis", "relation": "adverse effect", "tail": "Methotrexate"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
While 40 mg / day of prednisolone improved hepatic dysfunction dramatically , her diabetic milieu deteriorated seriously .
adverse effect: diabetic milieu deteriorated -> prednisolone
adverse effect
{"relations": [{"head": "diabetic milieu deteriorated", "relation": "adverse effect", "tail": "prednisolone"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Ulcerating enteritis associated with flucytosine therapy .
adverse effect: Ulcerating enteritis -> flucytosine
adverse effect
{"relations": [{"head": "Ulcerating enteritis", "relation": "adverse effect", "tail": "flucytosine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
CONCLUSION : This rare case of PTU - induced ANCA - associated vasculitis manifested with ototoxicity in combination with systemic involvement .
adverse effect: ototoxicity -> PTU | adverse effect: ANCA - associated vasculitis -> PTU
adverse effect
{"relations": [{"head": "ANCA - associated vasculitis", "relation": "adverse effect", "tail": "PTU"}, {"head": "ototoxicity", "relation": "adverse effect", "tail": "PTU"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding .
adverse effect: massive pulmonary bleeding -> MMC | adverse effect: HUS -> MMC
adverse effect
{"relations": [{"head": "HUS", "relation": "adverse effect", "tail": "MMC"}, {"head": "massive pulmonary bleeding", "relation": "adverse effect", "tail": "MMC"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
CONCLUSION : These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers .
adverse effect: corneal ulcers -> moxifloxacin
adverse effect
{"relations": [{"head": "corneal ulcers", "relation": "adverse effect", "tail": "moxifloxacin"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
CONCLUSION : During and after IFN therapy , OCT is a useful examination technique for revealing macular edema in patients who have decreased vision .
adverse effect: macular edema -> IFN | adverse effect: decreased vision -> IFN
adverse effect
{"relations": [{"head": "decreased vision", "relation": "adverse effect", "tail": "IFN"}, {"head": "macular edema", "relation": "adverse effect", "tail": "IFN"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Although the two local anesthetics usually do not cause methemoglobinemia , we suspect that the displacement of lidocaine from protein binding by bupivacaine , in combination with metabolic acidosis and treatment with other oxidants , was the reason for the development of methemoglobinemia .
adverse effect: methemoglobinemia -> lidocaine
adverse effect
{"relations": [{"head": "methemoglobinemia", "relation": "adverse effect", "tail": "lidocaine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Here we describe another case of VOD occurring after LT , but in which the causative role was played by azathioprine .
adverse effect: VOD -> azathioprine
adverse effect
{"relations": [{"head": "VOD", "relation": "adverse effect", "tail": "azathioprine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Hypo - oestrogenic and anabolic / androgenic side - effects of danazol are well known by the gynaecologist and some of them are present in > 50 % of patients being treated for endometriosis .
adverse effect: Hypo - oestrogenic and anabolic / androgenic side - effects -> danazol
adverse effect
{"relations": [{"head": "Hypo - oestrogenic and anabolic / androgenic side - effects", "relation": "adverse effect", "tail": "danazol"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine .
adverse effect: transient intraoperative hypertension -> epinephrine
adverse effect
{"relations": [{"head": "transient intraoperative hypertension", "relation": "adverse effect", "tail": "epinephrine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Inadvertent and accidental epinephrine overdose might result in potentially lethal complications .
adverse effect: lethal complications -> epinephrine
adverse effect
{"relations": [{"head": "lethal complications", "relation": "adverse effect", "tail": "epinephrine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
Acute pancreatitis is a known , although rare , complication of mesalamine treatment .
adverse effect: Acute pancreatitis -> mesalamine
adverse effect
{"relations": [{"head": "Acute pancreatitis", "relation": "adverse effect", "tail": "mesalamine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
RE
ADE_corpus_sample_15000
train
From these data , acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d - penicillamine therapy .
adverse effect: brainstem and thalamic lesions -> d - penicillamine | adverse effect: acute generalized dystonia -> d - penicillamine
adverse effect
{"relations": [{"head": "acute generalized dystonia", "relation": "adverse effect", "tail": "d - penicillamine"}, {"head": "brainstem and thalamic lesions", "relation": "adverse effect", "tail": "d - penicillamine"}]}
You are an expert in Relation Extraction. Your task is to extract relationships between entities in the given text. Follow these guidelines: 1. Only extract relations of the types specified in the schema. 2. Format your answer as 'relation_type: head_entity -> tail_entity' separated by '|'. 3. If no relations are found, return 'None'. 4. Be precise - identify the exact direction of each relation.
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