We are currently solving the following issue within our repository. Here is the issue text:
--- BEGIN ISSUE ---
opentelemetry-instrument command can cause recursive creation of subprocesses
**Describe your environment**

Python3.9, linux.

**Steps to reproduce**
Using `opentelemetry-instrument` with any exporter or instrumentation which invokes a python subprocess **during initialization**. For example, the `opentelemetry-exporter-gcp-trace` exporter may invoke the `gcloud` (written in python) command in a subprocess to get project information and authentication tokens. The subprocess will then try to autoinstrument, creating a recursive loop of subprocesses being created.

**What is the expected behavior?**
Auto-instrumentation should not apply to subprocesses created in the `initialize()` phase of auto-instrumentation. The `PYTHONPATH` environment variable should have the `sitecustomize.py` dirname stripped out at the beginning of `sitecustomize.py`. This would prevent subprocesses from being autoinstrumented during setup, which can cause a loop.

**What is the actual behavior?**
`PYTHONPATH` is correctly stripped later on to avoid this https://github.com/open-telemetry/opentelemetry-python-contrib/blob/e9f83e1292b0fe5f3478c9b23f3b5a5508481e68/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py#L120-L125

However, any subprocesses created in [these lines](https://github.com/open-telemetry/opentelemetry-python-contrib/blob/e9f83e1292b0fe5f3478c9b23f3b5a5508481e68/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py#L114-L117) will cause a loop.

**Additional context**
I can write a repro if necessary.

--- END ISSUE ---

Below are some code segments, each from a relevant file. One or more of these files may contain bugs.
--- BEGIN FILES ---
Path: `opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py`
Content:
```
1 # Copyright The OpenTelemetry Authors
2 #
3 # Licensed under the Apache License, Version 2.0 (the "License");
4 # you may not use this file except in compliance with the License.
5 # You may obtain a copy of the License at
6 #
7 #     http://www.apache.org/licenses/LICENSE-2.0
8 #
9 # Unless required by applicable law or agreed to in writing, software
10 # distributed under the License is distributed on an "AS IS" BASIS,
11 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
12 # See the License for the specific language governing permissions and
13 # limitations under the License.
14 
15 from logging import getLogger
16 from os import environ
17 from os.path import abspath, dirname, pathsep
18 from re import sub
19 
20 from pkg_resources import iter_entry_points
21 
22 from opentelemetry.instrumentation.dependencies import (
23     get_dist_dependency_conflicts,
24 )
25 from opentelemetry.instrumentation.distro import BaseDistro, DefaultDistro
26 from opentelemetry.instrumentation.environment_variables import (
27     OTEL_PYTHON_DISABLED_INSTRUMENTATIONS,
28 )
29 from opentelemetry.instrumentation.version import __version__
30 
31 logger = getLogger(__name__)
32 
33 
34 def _load_distros() -> BaseDistro:
35     for entry_point in iter_entry_points("opentelemetry_distro"):
36         try:
37             distro = entry_point.load()()
38             if not isinstance(distro, BaseDistro):
39                 logger.debug(
40                     "%s is not an OpenTelemetry Distro. Skipping",
41                     entry_point.name,
42                 )
43                 continue
44             logger.debug(
45                 "Distribution %s will be configured", entry_point.name
46             )
47             return distro
48         except Exception as exc:  # pylint: disable=broad-except
49             logger.exception(
50                 "Distribution %s configuration failed", entry_point.name
51             )
52             raise exc
53     return DefaultDistro()
54 
55 
56 def _load_instrumentors(distro):
57     package_to_exclude = environ.get(OTEL_PYTHON_DISABLED_INSTRUMENTATIONS, [])
58     if isinstance(package_to_exclude, str):
59         package_to_exclude = package_to_exclude.split(",")
60         # to handle users entering "requests , flask" or "requests, flask" with spaces
61         package_to_exclude = [x.strip() for x in package_to_exclude]
62 
63     for entry_point in iter_entry_points("opentelemetry_pre_instrument"):
64         entry_point.load()()
65 
66     for entry_point in iter_entry_points("opentelemetry_instrumentor"):
67         if entry_point.name in package_to_exclude:
68             logger.debug(
69                 "Instrumentation skipped for library %s", entry_point.name
70             )
71             continue
72 
73         try:
74             conflict = get_dist_dependency_conflicts(entry_point.dist)
75             if conflict:
76                 logger.debug(
77                     "Skipping instrumentation %s: %s",
78                     entry_point.name,
79                     conflict,
80                 )
81                 continue
82 
83             # tell instrumentation to not run dep checks again as we already did it above
84             distro.load_instrumentor(entry_point, skip_dep_check=True)
85             logger.debug("Instrumented %s", entry_point.name)
86         except Exception as exc:  # pylint: disable=broad-except
87             logger.exception("Instrumenting of %s failed", entry_point.name)
88             raise exc
89 
90     for entry_point in iter_entry_points("opentelemetry_post_instrument"):
91         entry_point.load()()
92 
93 
94 def _load_configurators():
95     configured = None
96     for entry_point in iter_entry_points("opentelemetry_configurator"):
97         if configured is not None:
98             logger.warning(
99                 "Configuration of %s not loaded, %s already loaded",
100                 entry_point.name,
101                 configured,
102             )
103             continue
104         try:
105             entry_point.load()().configure(auto_instrumentation_version=__version__)  # type: ignore
106             configured = entry_point.name
107         except Exception as exc:  # pylint: disable=broad-except
108             logger.exception("Configuration of %s failed", entry_point.name)
109             raise exc
110 
111 
112 def initialize():
113     try:
114         distro = _load_distros()
115         distro.configure()
116         _load_configurators()
117         _load_instrumentors(distro)
118     except Exception:  # pylint: disable=broad-except
119         logger.exception("Failed to auto initialize opentelemetry")
120     finally:
121         environ["PYTHONPATH"] = sub(
122             rf"{dirname(abspath(__file__))}{pathsep}?",
123             "",
124             environ["PYTHONPATH"],
125         )
126 
127 
128 initialize()
129
```
--- END FILES ---

Please first localize the bug based on the issue statement, and then generate a patch according to the `git diff` format fenced by three backticks.

Here is an example:

```diff
diff --git a/examples/server_async.py b/examples/server_async.py
--- a/examples/server_async.py
+++ b/examples/server_async.py
@@ -313,4 +313,4 @@
 
 
 if __name__ == "__main__":
-    asyncio.run(run_async_server("."), debug=True)
+    asyncio.run(run_async_server(), debug=True)
diff --git a/examples/server_sync.py b/examples/server_sync.py
--- a/examples/server_sync.py
+++ b/examples/server_sync.py
@@ -313,5 +313,5 @@
 
 
 if __name__ == "__main__":
-    server = run_sync_server(".")
+    server = run_sync_server()
     server.shutdown()

```

diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py
@@ -110,6 +110,13 @@
 
 
 def initialize():
+    # prevents auto-instrumentation of subprocesses if code execs another python process
+    environ["PYTHONPATH"] = sub(
+        rf"{dirname(abspath(__file__))}{pathsep}?",
+        "",
+        environ["PYTHONPATH"],
+    )
+
     try:
         distro = _load_distros()
         distro.configure()
@@ -117,12 +124,6 @@
         _load_instrumentors(distro)
     except Exception:  # pylint: disable=broad-except
         logger.exception("Failed to auto initialize opentelemetry")
-    finally:
-        environ["PYTHONPATH"] = sub(
-            rf"{dirname(abspath(__file__))}{pathsep}?",
-            "",
-            environ["PYTHONPATH"],
-        )
 
 
 initialize()

{"golden_diff": "diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py\n--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py\n+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py\n@@ -110,6 +110,13 @@\n \n \n def initialize():\n+    # prevents auto-instrumentation of subprocesses if code execs another python process\n+    environ[\"PYTHONPATH\"] = sub(\n+        rf\"{dirname(abspath(__file__))}{pathsep}?\",\n+        \"\",\n+        environ[\"PYTHONPATH\"],\n+    )\n+\n     try:\n         distro = _load_distros()\n         distro.configure()\n@@ -117,12 +124,6 @@\n         _load_instrumentors(distro)\n     except Exception:  # pylint: disable=broad-except\n         logger.exception(\"Failed to auto initialize opentelemetry\")\n-    finally:\n-        environ[\"PYTHONPATH\"] = sub(\n-            rf\"{dirname(abspath(__file__))}{pathsep}?\",\n-            \"\",\n-            environ[\"PYTHONPATH\"],\n-        )\n \n \n initialize()\n", "issue": "opentelemetry-instrument command can cause recursive creation of subprocesses\n**Describe your environment**\r\n\r\nPython3.9, linux.\r\n\r\n**Steps to reproduce**\r\nUsing `opentelemetry-instrument` with any exporter or instrumentation which invokes a python subprocess **during initialization**. For example, the `opentelemetry-exporter-gcp-trace` exporter may invoke the `gcloud` (written in python) command in a subprocess to get project information and authentication tokens. The subprocess will then try to autoinstrument, creating a recursive loop of subprocesses being created.\r\n\r\n**What is the expected behavior?**\r\nAuto-instrumentation should not apply to subprocesses created in the `initialize()` phase of auto-instrumentation. The `PYTHONPATH` environment variable should have the `sitecustomize.py` dirname stripped out at the beginning of `sitecustomize.py`. This would prevent subprocesses from being autoinstrumented during setup, which can cause a loop.\r\n\r\n**What is the actual behavior?**\r\n`PYTHONPATH` is correctly stripped later on to avoid this https://github.com/open-telemetry/opentelemetry-python-contrib/blob/e9f83e1292b0fe5f3478c9b23f3b5a5508481e68/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py#L120-L125\r\n\r\nHowever, any subprocesses created in [these lines](https://github.com/open-telemetry/opentelemetry-python-contrib/blob/e9f83e1292b0fe5f3478c9b23f3b5a5508481e68/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py#L114-L117) will cause a loop.\r\n\r\n**Additional context**\r\nI can write a repro if necessary.\n", "before_files": [{"content": "# Copyright The OpenTelemetry Authors\n#\n# Licensed under the Apache License, Version 2.0 (the \"License\");\n# you may not use this file except in compliance with the License.\n# You may obtain a copy of the License at\n#\n#     http://www.apache.org/licenses/LICENSE-2.0\n#\n# Unless required by applicable law or agreed to in writing, software\n# distributed under the License is distributed on an \"AS IS\" BASIS,\n# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.\n# See the License for the specific language governing permissions and\n# limitations under the License.\n\nfrom logging import getLogger\nfrom os import environ\nfrom os.path import abspath, dirname, pathsep\nfrom re import sub\n\nfrom pkg_resources import iter_entry_points\n\nfrom opentelemetry.instrumentation.dependencies import (\n    get_dist_dependency_conflicts,\n)\nfrom opentelemetry.instrumentation.distro import BaseDistro, DefaultDistro\nfrom opentelemetry.instrumentation.environment_variables import (\n    OTEL_PYTHON_DISABLED_INSTRUMENTATIONS,\n)\nfrom opentelemetry.instrumentation.version import __version__\n\nlogger = getLogger(__name__)\n\n\ndef _load_distros() -> BaseDistro:\n    for entry_point in iter_entry_points(\"opentelemetry_distro\"):\n        try:\n            distro = entry_point.load()()\n            if not isinstance(distro, BaseDistro):\n                logger.debug(\n                    \"%s is not an OpenTelemetry Distro. Skipping\",\n                    entry_point.name,\n                )\n                continue\n            logger.debug(\n                \"Distribution %s will be configured\", entry_point.name\n            )\n            return distro\n        except Exception as exc:  # pylint: disable=broad-except\n            logger.exception(\n                \"Distribution %s configuration failed\", entry_point.name\n            )\n            raise exc\n    return DefaultDistro()\n\n\ndef _load_instrumentors(distro):\n    package_to_exclude = environ.get(OTEL_PYTHON_DISABLED_INSTRUMENTATIONS, [])\n    if isinstance(package_to_exclude, str):\n        package_to_exclude = package_to_exclude.split(\",\")\n        # to handle users entering \"requests , flask\" or \"requests, flask\" with spaces\n        package_to_exclude = [x.strip() for x in package_to_exclude]\n\n    for entry_point in iter_entry_points(\"opentelemetry_pre_instrument\"):\n        entry_point.load()()\n\n    for entry_point in iter_entry_points(\"opentelemetry_instrumentor\"):\n        if entry_point.name in package_to_exclude:\n            logger.debug(\n                \"Instrumentation skipped for library %s\", entry_point.name\n            )\n            continue\n\n        try:\n            conflict = get_dist_dependency_conflicts(entry_point.dist)\n            if conflict:\n                logger.debug(\n                    \"Skipping instrumentation %s: %s\",\n                    entry_point.name,\n                    conflict,\n                )\n                continue\n\n            # tell instrumentation to not run dep checks again as we already did it above\n            distro.load_instrumentor(entry_point, skip_dep_check=True)\n            logger.debug(\"Instrumented %s\", entry_point.name)\n        except Exception as exc:  # pylint: disable=broad-except\n            logger.exception(\"Instrumenting of %s failed\", entry_point.name)\n            raise exc\n\n    for entry_point in iter_entry_points(\"opentelemetry_post_instrument\"):\n        entry_point.load()()\n\n\ndef _load_configurators():\n    configured = None\n    for entry_point in iter_entry_points(\"opentelemetry_configurator\"):\n        if configured is not None:\n            logger.warning(\n                \"Configuration of %s not loaded, %s already loaded\",\n                entry_point.name,\n                configured,\n            )\n            continue\n        try:\n            entry_point.load()().configure(auto_instrumentation_version=__version__)  # type: ignore\n            configured = entry_point.name\n        except Exception as exc:  # pylint: disable=broad-except\n            logger.exception(\"Configuration of %s failed\", entry_point.name)\n            raise exc\n\n\ndef initialize():\n    try:\n        distro = _load_distros()\n        distro.configure()\n        _load_configurators()\n        _load_instrumentors(distro)\n    except Exception:  # pylint: disable=broad-except\n        logger.exception(\"Failed to auto initialize opentelemetry\")\n    finally:\n        environ[\"PYTHONPATH\"] = sub(\n            rf\"{dirname(abspath(__file__))}{pathsep}?\",\n            \"\",\n            environ[\"PYTHONPATH\"],\n        )\n\n\ninitialize()\n", "path": "opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py"}], "after_files": [{"content": "# Copyright The OpenTelemetry Authors\n#\n# Licensed under the Apache License, Version 2.0 (the \"License\");\n# you may not use this file except in compliance with the License.\n# You may obtain a copy of the License at\n#\n#     http://www.apache.org/licenses/LICENSE-2.0\n#\n# Unless required by applicable law or agreed to in writing, software\n# distributed under the License is distributed on an \"AS IS\" BASIS,\n# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.\n# See the License for the specific language governing permissions and\n# limitations under the License.\n\nfrom logging import getLogger\nfrom os import environ\nfrom os.path import abspath, dirname, pathsep\nfrom re import sub\n\nfrom pkg_resources import iter_entry_points\n\nfrom opentelemetry.instrumentation.dependencies import (\n    get_dist_dependency_conflicts,\n)\nfrom opentelemetry.instrumentation.distro import BaseDistro, DefaultDistro\nfrom opentelemetry.instrumentation.environment_variables import (\n    OTEL_PYTHON_DISABLED_INSTRUMENTATIONS,\n)\nfrom opentelemetry.instrumentation.version import __version__\n\nlogger = getLogger(__name__)\n\n\ndef _load_distros() -> BaseDistro:\n    for entry_point in iter_entry_points(\"opentelemetry_distro\"):\n        try:\n            distro = entry_point.load()()\n            if not isinstance(distro, BaseDistro):\n                logger.debug(\n                    \"%s is not an OpenTelemetry Distro. Skipping\",\n                    entry_point.name,\n                )\n                continue\n            logger.debug(\n                \"Distribution %s will be configured\", entry_point.name\n            )\n            return distro\n        except Exception as exc:  # pylint: disable=broad-except\n            logger.exception(\n                \"Distribution %s configuration failed\", entry_point.name\n            )\n            raise exc\n    return DefaultDistro()\n\n\ndef _load_instrumentors(distro):\n    package_to_exclude = environ.get(OTEL_PYTHON_DISABLED_INSTRUMENTATIONS, [])\n    if isinstance(package_to_exclude, str):\n        package_to_exclude = package_to_exclude.split(\",\")\n        # to handle users entering \"requests , flask\" or \"requests, flask\" with spaces\n        package_to_exclude = [x.strip() for x in package_to_exclude]\n\n    for entry_point in iter_entry_points(\"opentelemetry_pre_instrument\"):\n        entry_point.load()()\n\n    for entry_point in iter_entry_points(\"opentelemetry_instrumentor\"):\n        if entry_point.name in package_to_exclude:\n            logger.debug(\n                \"Instrumentation skipped for library %s\", entry_point.name\n            )\n            continue\n\n        try:\n            conflict = get_dist_dependency_conflicts(entry_point.dist)\n            if conflict:\n                logger.debug(\n                    \"Skipping instrumentation %s: %s\",\n                    entry_point.name,\n                    conflict,\n                )\n                continue\n\n            # tell instrumentation to not run dep checks again as we already did it above\n            distro.load_instrumentor(entry_point, skip_dep_check=True)\n            logger.debug(\"Instrumented %s\", entry_point.name)\n        except Exception as exc:  # pylint: disable=broad-except\n            logger.exception(\"Instrumenting of %s failed\", entry_point.name)\n            raise exc\n\n    for entry_point in iter_entry_points(\"opentelemetry_post_instrument\"):\n        entry_point.load()()\n\n\ndef _load_configurators():\n    configured = None\n    for entry_point in iter_entry_points(\"opentelemetry_configurator\"):\n        if configured is not None:\n            logger.warning(\n                \"Configuration of %s not loaded, %s already loaded\",\n                entry_point.name,\n                configured,\n            )\n            continue\n        try:\n            entry_point.load()().configure(auto_instrumentation_version=__version__)  # type: ignore\n            configured = entry_point.name\n        except Exception as exc:  # pylint: disable=broad-except\n            logger.exception(\"Configuration of %s failed\", entry_point.name)\n            raise exc\n\n\ndef initialize():\n    # prevents auto-instrumentation of subprocesses if code execs another python process\n    environ[\"PYTHONPATH\"] = sub(\n        rf\"{dirname(abspath(__file__))}{pathsep}?\",\n        \"\",\n        environ[\"PYTHONPATH\"],\n    )\n\n    try:\n        distro = _load_distros()\n        distro.configure()\n        _load_configurators()\n        _load_instrumentors(distro)\n    except Exception:  # pylint: disable=broad-except\n        logger.exception(\"Failed to auto initialize opentelemetry\")\n\n\ninitialize()\n", "path": "opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py"}]}